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TDMS Study 05068-09 Pathology Tables

                                              NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
                                                              CODEINE


NTP Experiment-Test: 05068-09                                                                                     Report: PEIRPT09
Study Type: CHRONIC                                                                                               Date: 08/29/94
Route: DOSED FEED                                                                                                 Time: 22:00:01


                                                       2 YEAR CORE STUDY


       Facility:  Microbiological Associates

       Chemical CAS #:  76-57-3

       Lock Date:  04/19/94

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 002    0 PPM
                               Include 004    400 PPM
                               Include 006    800 PPM
                               Include 008    1600    PPM
                               Include 001    0 PPM
                               Include 003    400  PPM
                               Include 005    800 PPM
                               Include 007    1600    PPM

























                                                             Page   1
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 7| 7| 4| 4| 7| 5|             
                             DAY ON TEST   | 7| 3| 3| 8| 3| 2| 3| 3| 3| 1| 3| 8| 3| 3| 7| 8| 3| 3| 1| 3| 3| 3| 7| 3| 9|             
                                           | 5| 6| 5| 1| 5| 5| 6| 1| 5| 2| 5| 1| 4| 4| 3| 7| 4| 6| 3| 3| 6| 2| 5| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
                                           | 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 1  2  2     2     1  3  2  2  2     1  2  2  2  2  3     2  2            |             
      Clear Cell Focus                     |       1              1                                   2               |             
      Degeneration                         |                            3                                             |             
      Developmental Malformation           |                         2                                                |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |    3        2              2     2                    2                 1|             
      Hematopoietic Cell Proliferation     |                                                             2            |             
      Hepatodiaphragmatic Nodule           |                                                                   X      |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         | 1           2                                2                           |             
      Leukocytosis                         |                                                             2            |             
      Necrosis                             |                                                    2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +     +  +            |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Fat, Necrosis                        |                                                    3     3  2            |             
      Lymphatic, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Gingival, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2                                                                  |             
      Inflammation                         |                                                                          |             
      Acinar Cell, Atrophy                 | 2                 1           2  2  1     2  2  1        1  2  2  2      |             
      Acinar Cell, Hyperplasia             |       1                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2                                   1         |             
      Inflammation                         |                                                                          |             
      Ulcer                                |                            4                                            3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 7| 7| 4| 4| 7| 5|             
                             DAY ON TEST   | 7| 3| 3| 8| 3| 2| 3| 3| 3| 1| 3| 8| 3| 3| 7| 8| 3| 3| 1| 3| 3| 3| 7| 3| 9|             
                                           | 5| 6| 5| 1| 5| 5| 6| 1| 5| 2| 5| 1| 4| 4| 3| 7| 4| 6| 3| 3| 6| 2| 5| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
                                           | 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 2  2                 1  1     1                             3            |             
      Valve, Pigmentation                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2  1     2        2                          1        1               |             
      Cytologic Alterations                |                                                                          |             
      Hypertrophy                          |                   1                                                      |             
      Vacuolization Cytoplasmic, Focal     |                2                 2        2                              |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1                       1              2        1                     |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    4     3        3           3     3           3  4                     |             
      Pars Distalis, Cyst                  | 2                    2                 3        3           2           3|             
      Pars Distalis, Hyperplasia           |       2              2           2           2  2     3  2               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2                                   2                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
      Ectasia                              |                                                       2           2      |             
      Hyperplasia                          |             2                 3                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             2                                   3                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                   2                                                      |             
      Hemorrhage                           |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       2                  |             
      Erythroid Cell, Atrophy              |                            3                                             |             
      Erythroid Cell, Hyperplasia          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +                    +              +     +     +     +     +      |             
      Iliac, Hyperplasia, Plasma Cell      |                                                       3                  |             
      Mediastinal, Cyst                    |                                                                          |             
      Mediastinal, Hemorrhage              |    3  2                    2                                             |             
      Mediastinal, Pigmentation            |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 7| 7| 4| 4| 7| 5|             
                             DAY ON TEST   | 7| 3| 3| 8| 3| 2| 3| 3| 3| 1| 3| 8| 3| 3| 7| 8| 3| 3| 1| 3| 3| 3| 7| 3| 9|             
                                           | 5| 6| 5| 1| 5| 5| 6| 1| 5| 2| 5| 1| 4| 4| 3| 7| 4| 6| 3| 3| 6| 2| 5| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
                                           | 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Plasma Cell             |    2                                                                     |             
      Infiltration Cellular, Histiocyte    |                                                       2                  |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |                      1                                                   |             
      Infiltration Cellular, Histiocyte    |                                                       2                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            2                                             |             
      Depletion Lymphoid                   |                            3                                             |             
      Hematopoietic Cell Proliferation     |                                                    3  3                 2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M|             
      Atrophy                              | 2     2     2        2  1  4  2  3     2  2  2                 2     2   |             
      Congestion                           |                                  3                                       |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                         3                                                |             
      Hyperplasia                          |       2  2                 2                    2              1         |             
      Lactation                            |          3     2              2     2        3                       2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                                                                      X   |             
      Femur, Hyperostosis                  |                                  2                 3                     |             
      Turbinate, Hyperostosis              |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                    2                 3   |             
      Hydrocephalus                        |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Infiltration Cellular, Histiocyte    |                         1                    1  1                        |             
      Inflammation                         |                      2           3     1                                 |             
      Leukocytosis                         |                            2                                             |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 7| 7| 4| 4| 7| 5|             
                             DAY ON TEST   | 7| 3| 3| 8| 3| 2| 3| 3| 3| 1| 3| 8| 3| 3| 7| 8| 3| 3| 1| 3| 3| 3| 7| 3| 9|             
                                           | 5| 6| 5| 1| 5| 5| 6| 1| 5| 2| 5| 1| 4| 4| 3| 7| 4| 6| 3| 3| 6| 2| 5| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
                                           | 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                            2                                             |             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       |    1  1  2     3  1  1  2  1  1     1  1  1  1  1  1     1  1     1  1  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
      Lens, Cataract                       |                                                                      2   |             
      Lens, Hyperplasia                    |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                     2                                    |             
      Mineralization                       | 1                                1                                       |             
      Nephropathy, Chronic                 | 1  2  2     1     2     2  1  1     2  2  1  1  1        1  1        1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 5| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 5| 5| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 8| 4| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 4| 3| 9|            |
                                           | 3| 4| 3| 4| 6| 4| 4| 3| 5| 3| 9| 7| 5| 0| 6| 5| 4| 3| 7| 4| 6| 4| 8| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0 PPM                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    2  2     2  2  1  2     1  1  3  2  2  3  3  2  2  2  3     2  1  1  2|     38  1.9|
      Clear Cell Focus                     |                                              1  2                        |      5  1.4|
      Degeneration                         |                                                                          |      1  3.0|
      Developmental Malformation           |          2                                            2                  |      3  2.0|
      Eosinophilic Focus                   |                      1              3  2     2  2                        |      5  2.0|
      Fatty Change                         |          2        1        1                                            2|     10  1.8|
      Hematopoietic Cell Proliferation     |       1                                                                  |      2  1.5|
      Hepatodiaphragmatic Nodule           |                                                                X         |      2     |
      Infiltration Cellular, Lymphocyte    |                   2                       2                              |      2  2.0|
      Inflammation                         |                                                 1                        |      4  1.5|
      Leukocytosis                         |                                                                          |      1  2.0|
      Necrosis                             |                                           2                              |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                          +  +                           |   6        |
      Infiltration Cellular, Lymphocyte    |                                           3                              |      1  3.0|
      Fat, Necrosis                        |                2                             2                           |      5  2.4|
      Lymphatic, Cyst                      |                                           4                              |      1  4.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |    +                                         +  +                        |   3        |
      Gingival, Cyst                       |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation                         |                   2                       3                              |      2  2.5|
      Acinar Cell, Atrophy                 | 2     2  3        2  2     1        1  1  2  2           1  2            |     24  1.7|
      Acinar Cell, Hyperplasia             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                               2                                          |      3  1.7|
      Inflammation                         |                         1     2                                          |      2  1.5|
      Ulcer                                |                                                                          |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 5| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 5| 5| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 8| 4| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 4| 3| 9|            |
                                           | 3| 4| 3| 4| 6| 4| 4| 3| 5| 3| 9| 7| 5| 0| 6| 5| 4| 3| 7| 4| 6| 4| 8| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0 PPM                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2     1     1                       1     1                             1|     12  1.4|
      Valve, Pigmentation                  |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 1     1     1  2                                2  3     2               |     13  1.6|
      Cytologic Alterations                |                                                       1                  |      1  1.0|
      Hypertrophy                          |                                                                      2   |      2  1.5|
      Vacuolization Cytoplasmic, Focal     |       2                                      2              2  1         |      7  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    1        1                             2        2                     |      8  1.4|
      Infiltration Cellular, Lymphocyte    |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
      Pars Distalis, Angiectasis           | 2     2           4                    3                 3  2            |     13  3.0|
      Pars Distalis, Cyst                  |                      2              3  3        3  2     3        2      |     13  2.5|
      Pars Distalis, Hyperplasia           |       2     3     2              1     3        2                        |     13  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                                                 1              2         |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  47        |
      Ectasia                              |                   2                                      3     2         |      5  2.2|
      Hyperplasia                          | 2  2        2                                   3     2        2        3|      9  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          3     4  4                                      2     2         |      7  2.9|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                          2     3         |      3  2.3|
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 5| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 5| 5| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 8| 4| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 4| 3| 9|            |
                                           | 3| 4| 3| 4| 6| 4| 4| 3| 5| 3| 9| 7| 5| 0| 6| 5| 4| 3| 7| 4| 6| 4| 8| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0 PPM                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                            2                                             |      2  2.0|
      Erythroid Cell, Atrophy              |                                                                          |      1  3.0|
      Erythroid Cell, Hyperplasia          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +     +                       +        +                     |  12        |
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
      Mediastinal, Cyst                    |                                           3                              |      1  3.0|
      Mediastinal, Hemorrhage              |             2                             1        2                     |      6  2.0|
      Mediastinal, Pigmentation            |                   2                                2                     |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                               2              3                           |      2  2.5|
      Hyperplasia, Plasma Cell             |                                                    3                     |      2  2.5|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Pigmentation                         |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                           3                              |      1  3.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  2.0|
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |    1                                      2                              |      5  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Atrophy                              | 2           2     3  2  3     2  2     2  2  3  2     3     2     2  3  3|     29  2.3|
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                               1                                   2      |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                                                          |      1  3.0|
      Hyperplasia                          |    2                       2                          2                  |      8  1.9|
      Lactation                            |       2           2     3              1     2           2           2  2|     14  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis                |                                           3                              |      2  3.0|
      Femur, Hyperostosis                  |                                           3                              |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 5| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 5| 5| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 8| 4| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 4| 3| 9|            |
                                           | 3| 4| 3| 4| 6| 4| 4| 3| 5| 3| 9| 7| 5| 0| 6| 5| 4| 3| 7| 4| 6| 4| 8| 2| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0 PPM                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Turbinate, Hyperostosis              |                                           3                              |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |          2        2        3  3              2           2               |      8  2.4|
      Hydrocephalus                        |                               3                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |             1                          2  2                              |      3  1.7|
      Infiltration Cellular, Histiocyte    |                            1                 1  1                        |      6  1.0|
      Inflammation                         |                   1                 1           1                       1|      7  1.4|
      Leukocytosis                         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                            1                 1                           |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                1         |      2  1.5|
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       |    2  2  1  1  1  2  1  2     1     1     2  2  2  1     1     1     2  2|     38  1.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  2.0|
      Lens, Hyperplasia                    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                                          |      1  2.0|
      Mineralization                       |                                        1                                 |      3  1.0|
      Nephropathy, Chronic                 | 2  2  2  1  1  2  1  2     1  2  1  2  1  1  2  1  2  1  2  1  1  1     1|     39  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 1| 3| 3| 3| 0| 3| 8| 3| 3| 0| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 3| 2| 4| 5| 5| 7| 4| 9| 6| 4| 0| 5| 4| 5| 6| 4| 4| 4| 4| 5| 3| 1| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    400 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 0| 1| 3| 6| 7| 8| 9| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Intussusception                      |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          1     1     2     1  2  1  2  2  1  1  2  2     2  2  2     1  2|             
      Clear Cell Focus                     |                            1              1                              |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |                                                             3            |             
      Fatty Change                         |                               1                                          |             
      Hepatodiaphragmatic Nodule           |                                                 2  2        3            |             
      Infiltration Cellular, Lymphocyte    |                                                                         1|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                       +        +               |             
      Fat, Inflammation                    |                                                 2                        |             
      Fat, Necrosis                        |                         2                                2               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Acinar Cell, Atrophy                 |    2                                         2  1  1     3  2  1         |             
      Artery, Inflammation                 |                                                             3            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                         1                                         1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                 1        1     1         |             
      Hypertrophy                          |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                         2|             
      Hyperplasia, Focal                   |                            1              1                    2         |             
      Hypertrophy                          |                                                 2                        |             
      Vacuolization Cytoplasmic, Focal     |          2                                            1     2     2      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 1| 3| 3| 3| 0| 3| 8| 3| 3| 0| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 3| 2| 4| 5| 5| 7| 4| 9| 6| 4| 0| 5| 4| 5| 6| 4| 4| 4| 4| 5| 3| 1| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    400 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 0| 1| 3| 6| 7| 8| 9| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |             2           1                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                               2                    3        2           2|             
      Pars Distalis, Cyst                  |                            2  2     2           2  2                 2   |             
      Pars Distalis, Hyperplasia           | 2  2     2                                         3     2           3  3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1  1              2  2        2                 2              1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Ectasia                              |       3     3                                      4     2  2  2        2|             
      Hyperplasia                          |                   2                             2                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    2                                                                     |             
      Dilatation                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              2           2     3         |             
      Infiltration Cellular, Histiocyte    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                       +  +                          +        +  +      |             
      Mediastinal, Hemorrhage              |                            2                                             |             
      Mediastinal, Pigmentation            |                                                                2         |             
      Pancreatic, Pigmentation             | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |          2        3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                      2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          2               |             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Necrosis                             |             4                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Amyloid Deposition                   |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 1| 3| 3| 3| 0| 3| 8| 3| 3| 0| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 3| 2| 4| 5| 5| 7| 4| 9| 6| 4| 0| 5| 4| 5| 6| 4| 4| 4| 4| 5| 3| 1| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    400 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 0| 1| 3| 6| 7| 8| 9| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Atrophy                              | 3  2           2        2  2        2  2  2  2  2  3  3     2        3  2|             
      Hemorrhage                           |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                     3                                   3|             
      Hyperplasia                          |                      2  2           2                       1            |             
      Infiltration Cellular, Histiocyte    |                   3                                                      |             
      Lactation                            |       2  2        3  2     2        2  2  3           2  2  2           2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               2                                          |             
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |             
          Inclusion                        |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |          2           2                                                   |             
      Femur, Hyperostosis                  |       2              2        3                                   2      |             
      Turbinate, Hyperostosis              |       2              2                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       3                                2              1        3         |             
      Hemorrhage                           |    2              3                                                      |             
      Hydrocephalus                        |       3                                                                  |             
      Necrosis                             |    2                                                                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                   1                       1                          1   |             
      Inflammation                         |                            2        1                                   2|             
      Alveolar Epithelium, Hyperplasia     |                                        2                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   1                    2                                 |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       | 2  2  1  3  2  2  1  1  2  3  2  2  2  2  1  2  2  2  1  1  2  3  2  3  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 1| 3| 3| 3| 0| 3| 8| 3| 3| 0| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 3| 2| 4| 5| 5| 7| 4| 9| 6| 4| 0| 5| 4| 5| 6| 4| 4| 4| 4| 5| 3| 1| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    400 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 0| 1| 3| 6| 7| 8| 9| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              | 2           3                                                            |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Mineralization                       | 1                                                                        |             
      Nephropathy, Chronic                 | 2     2  3     1     3     2  2  1  2  2  2  1  2  2  2     2  1     1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 6| 5| 4| 4| 4| 1| 5| 4| 4| 6| 9| 4| 4| 5| 5| 6| 5| 3| 5| 6| 9| 6| 3| 5| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    400 PPM                                | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|      L     |
                                           | 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Intussusception                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | 2  2  2     1     3  2  1  2     1  2  2  2     2  2  1  2     3  2  3   |     36  1.8|
      Clear Cell Focus                     |       1     1                                                            |      4  1.0|
      Developmental Malformation           |                      2                             2                     |      2  2.0|
      Eosinophilic Focus                   |                                                    1                     |      2  2.0|
      Fatty Change                         |    1              1                    1                                 |      4  1.0|
      Hepatodiaphragmatic Nodule           |                3                                                     3   |      5  2.6|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Inflammation                         |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                    +                                    |   5        |
      Fat, Inflammation                    |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                     2                                    |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                         1|      1  1.0|
      Acinar Cell, Atrophy                 |    1              2  2                    2                 2            |     12  1.8|
      Artery, Inflammation                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                2              1           2                 2            |      4  1.8|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                2                                                         |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       1           1                                      2           1   |      7  1.1|
      Hypertrophy                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 6| 5| 4| 4| 4| 1| 5| 4| 4| 6| 9| 4| 4| 5| 5| 6| 5| 3| 5| 6| 9| 6| 3| 5| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    400 PPM                                | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|      L     |
                                           | 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis                          | 1                       2        1  2              2                     |      6  1.7|
      Hyperplasia, Focal                   |       1                                         2     1        2  1     1|      9  1.3|
      Hypertrophy                          |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                         2                                      2         |      6  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2                                                        1  1            |      5  1.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  M  M  +  +  M  +  +  M  +  M  M  +  +  +  +  M  +  +  +  M  +  +|  37        |
      Hyperplasia                          |                                           2        2                     |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                   3                       3        2                     |      7  2.4|
      Pars Distalis, Cyst                  | 2  2     2                 3     3     2        2              2     2  2|     16  2.1|
      Pars Distalis, Hyperplasia           |    2     2  2        2     2        2     3  1     3  2              1   |     18  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 1  1                       1              2                              |     11  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|  47        |
      Ectasia                              |                                        3        3                        |      9  2.7|
      Hyperplasia                          |       3  2                 3                                      1  3   |      7  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       2                                      2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Dilatation                           |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2                                      2                                 |      5  2.2|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +              +                          +  +            |  10        |
      Mediastinal, Hemorrhage              |                                                          3               |      2  2.5|
      Mediastinal, Pigmentation            |                                                          2               |      2  2.0|
      Pancreatic, Pigmentation             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |    1                                                                     |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 6| 5| 4| 4| 4| 1| 5| 4| 4| 6| 9| 4| 4| 5| 5| 6| 5| 3| 5| 6| 9| 6| 3| 5| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    400 PPM                                | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|      L     |
                                           | 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |       1                                                                  |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |    2                                                                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                1         |      2  1.5|
      Hyperplasia, Lymphoid                |                                                                      2   |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Atrophy                              |    1  1              2  1  2        2  2  2  1        2     2  2  2  2   |     29  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                                                          |      2  3.0|
      Hyperplasia                          |       2                    2                                      2      |      7  1.9|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Lactation                            | 2                 3     2              3  2  2  2  2        3  2     2   |     23  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |            |
          Inclusion                        |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis                |                   3                                                      |      3  2.3|
      Femur, Hyperostosis                  |       2           2                                                      |      6  2.2|
      Turbinate, Hyperostosis              |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      4  2.3|
      Hemorrhage                           |                                                                          |      2  2.5|
      Hydrocephalus                        |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                               +                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 6| 5| 4| 4| 4| 1| 5| 4| 4| 6| 9| 4| 4| 5| 5| 6| 5| 3| 5| 6| 9| 6| 3| 5| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    400 PPM                                | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|      L     |
                                           | 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                  2                                   1   |      2  1.5|
      Infiltration Cellular, Histiocyte    |                                                 1                        |      4  1.0|
      Inflammation                         |    1  1              2           1     2              1                  |      9  1.4|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |    1                          2                             2            |      5  1.6|
      Nasolacrimal Duct, Inflammation      |                                                    2                     |      1  2.0|
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       | 1  2  2  2  2  2  2  1     1  2  1        1  1  2  2  1  2  1        1  2|     45  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                        +                                 |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                          3               |      3  2.7|
      Infiltration Cellular, Lymphocyte    |                            3                                             |      1  3.0|
      Mineralization                       |                                                                          |      1  1.0|
      Nephropathy, Chronic                 | 2  2  2     2     2  1  2  2  1  2  2  1  3  2  1  1  2  2     2  3  1  1|     41  1.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 7| 7| 3| 6| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 0| 3| 3| 3| 7| 3| 0| 6| 4| 3| 3| 4| 3| 2| 3| 3| 0| 5| 3| 8| 3| 3| 3| 3|             
                                           | 6| 6| 4| 3| 3| 0| 4| 7| 5| 1| 4| 6| 1| 5| 7| 5| 3| 7| 9| 4| 4| 5| 6| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 1  2  3        2  2        2     1  1  2  1  2  2  2  1  2        2     1|             
      Congestion                           |                                                             1            |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                       1     2            |             
      Hematopoietic Cell Proliferation     |                                                             1            |             
      Hepatodiaphragmatic Nodule           |             2                                            2               |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         | 1     2                    1           1                                1|             
      Leukocytosis                         |                                                                          |             
      Mixed Cell Focus                     |                                                 3                        |             
      Necrosis                             |                                                                          |             
      Centrilobular, Degeneration          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                   +                 +     +|             
      Fat, Necrosis                        |             3                                   2                 3     2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         |                         2                                                |             
      Acinar Cell, Atrophy                 | 1        1                 2  2        2     2     1              2     1|             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                 +                        |             
      Palate, Hyperplasia                  |                                                 4                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2     3                                             |             
      Inflammation                         |                                                                          |             
      Ulcer                                |                      3     4                       2                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |             3              2                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                            1     2                                      1|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Atrium, Dilatation                   |                                                    3                     |             
      Atrium, Thrombosis                   |                                                                          |             
      Coronary Artery, Inflammation        |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 7| 7| 3| 6| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 0| 3| 3| 3| 7| 3| 0| 6| 4| 3| 3| 4| 3| 2| 3| 3| 0| 5| 3| 8| 3| 3| 3| 3|             
                                           | 6| 6| 4| 3| 3| 0| 4| 7| 5| 1| 4| 6| 1| 5| 7| 5| 3| 7| 9| 4| 4| 5| 6| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Valve, Inflammation, Chronic         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2                                                      |             
      Congestion                           |                                     2                                    |             
      Cytologic Alterations                |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |       2           2        1        1                       1     3      |             
      Necrosis                             |                      3                                                   |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       2        3  2                 4        3                           |             
      Pars Distalis, Cyst                  | 2        3        2           2     2           4        2               |             
      Pars Distalis, Hyperplasia           |       3        2              2  2  1                    2           2   |             
      Pars Intermedia, Angiectasis         |                                                                         3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                   1                                         1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      2     2  2                          3               |             
      Hyperplasia                          | 2           2  2     1                 2        2     3                  |             
      Inflammation                         |                3                                                         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                2                                                         |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    2                                                                    2|             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                  4     3                                 |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                 +                        |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 7| 7| 3| 6| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 0| 3| 3| 3| 7| 3| 0| 6| 4| 3| 3| 4| 3| 2| 3| 3| 0| 5| 3| 8| 3| 3| 3| 3|             
                                           | 6| 6| 4| 3| 3| 0| 4| 7| 5| 1| 4| 6| 1| 5| 7| 5| 3| 7| 9| 4| 4| 5| 6| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                             3                          3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                  +                             +         |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Renal, Hemorrhage                    |                                  2                                       |             
      Renal, Pigmentation                  |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Congestion                           |                                                    2                     |             
      Hemorrhage                           |                                     2                                    |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                  3                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2           2                                   3        3            |             
      Hyperplasia, Lymphoid                |       4                                                                  |             
      Pigmentation                         |                                                       2                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2  3  2     3  3  2     3  3  1                    2  2  3            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Galactocele                          |                                        4                                 |             
      Hyperplasia                          |    2  2     3                       2                                    |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation                         |                                        3                                 |             
      Lactation                            | 2     3     3     2        2  3  3     2     2  1           3  3  2     2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                                              2                           |             
      Femur, Hyperostosis                  |                                                                          |             
      Maxilla, Hyperostosis                |                                                                          |             
      Turbinate, Hyperostosis              |       3                                                              3   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                            3                    3     2                  |             
      Degeneration, Focal                  |                                                                          |             
      Hemorrhage                           |                                     2                                    |             
      Hydrocephalus                        |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 6| 7| 7| 3| 6| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 0| 3| 3| 3| 7| 3| 0| 6| 4| 3| 3| 4| 3| 2| 3| 3| 0| 5| 3| 8| 3| 3| 3| 3|             
                                           | 6| 6| 4| 3| 3| 0| 4| 7| 5| 1| 4| 6| 1| 5| 7| 5| 3| 7| 9| 4| 4| 5| 6| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Meninges, Inflammation, Focal        |                                                                          |             
      Meninges, Thrombosis, Focal          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                            2        3              2                     |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Infiltration Cellular, Histiocyte    |                   1                    1                                1|             
      Inflammation                         | 2     1                                                                 2|             
      Alveolar Epithelium, Hyperplasia     |                                     2                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                                2         |             
      Edema, Focal                         |                         2                 2                              |             
      Foreign Body                         |    2                                                                     |             
      Inflammation                         |    1     2           3                 1                 1               |             
      Nasolacrimal Duct, Inflammation      |                                                 2        2               |             
      Olfactory Epithelium, Atrophy, Focal |                         2                 2                              |             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       | 2  2  2  2  2  2  2  3  2  1  2  2     1  2  2  3  2  2  2  2     2  1  2|             
      Respiratory Epithelium, Hyperplasia  |    1                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +                        |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Hemorrhage                           |                               3                                          |             
      Retina, Degeneration                 |                               3                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +           +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                      3                                                   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Necrosis                             |                                                                          |             
      Nephropathy, Chronic                 | 1  2  2  1     2  2        1  2  3  1  2  1  2  2     2  2  2  2  1  2  2|             
      Bilateral, Hydronephrosis            |                                                    4                     |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 7| 9| 3| 4| 0| 3| 3| 7| 3| 6| 3| 3| 3| 3| 2|             
                                           | 5| 5| 6| 5| 5| 5| 5| 7| 5| 4| 3| 4| 6| 3| 0| 5| 6| 7| 4| 2| 6| 3| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    800 PPM                                | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 2  2           2     1        1     1  2        2     2  1  2  2  2  3   |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |       2                       2     2                                    |             
      Fatty Change                         |                                     1                             2      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                            X                       3                     |             
      Infiltration Cellular, Lymphocyte    |             2                                            1               |             
      Inflammation                         | 1        2  2                 1                          2               |             
      Leukocytosis                         |                      2                                                   |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |          2  2                    2                                       |             
      Centrilobular, Degeneration          |                                  4                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +  +|             
      Fat, Necrosis                        |                                                                      2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                             1            |             
      Inflammation                         |                                                                          |             
      Acinar Cell, Atrophy                 | 2  1  3     2        1  1                    2  1  1                 1  1|             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2                     |             
      Inflammation                         |                               2                                          |             
      Ulcer                                |                                                          3               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          2  1  1              1  2     1  2  1        1  1  2  2         |             
      Infiltration Cellular, Lymphocyte    |             3                                                            |             
      Atrium, Dilatation                   |                                                                          |             
      Atrium, Thrombosis                   |                                  2                                       |             
      Coronary Artery, Inflammation        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 7| 9| 3| 4| 0| 3| 3| 7| 3| 6| 3| 3| 3| 3| 2|             
                                           | 5| 5| 6| 5| 5| 5| 5| 7| 5| 4| 3| 4| 6| 3| 0| 5| 6| 7| 4| 2| 6| 3| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    800 PPM                                | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Valve, Inflammation, Chronic         |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               1                          1  2  1  1      |             
      Congestion                           |                                                                          |             
      Cytologic Alterations                |                                                       2                  |             
      Fibrosis                             |                      2                                                   |             
      Hematopoietic Cell Proliferation     |                                           1                              |             
      Hyperplasia, Focal                   |                2              2                                          |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                  2                                       |             
      Vacuolization Cytoplasmic, Focal     |                                  2  2           2        2               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    4     2                       2  4                 3                  |             
      Pars Distalis, Cyst                  |          2  2  1                       4           4  2     1  3         |             
      Pars Distalis, Hyperplasia           |       1        3        2        2     2        2                        |             
      Pars Intermedia, Angiectasis         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1                                      1                          1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                2                                               2     4   |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          2     1     4                                                   |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 1  2              2                                            1         |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |       +                                                                  |             
      Inflammation                         |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 7| 9| 3| 4| 0| 3| 3| 7| 3| 6| 3| 3| 3| 3| 2|             
                                           | 5| 5| 6| 5| 5| 5| 5| 7| 5| 4| 3| 4| 6| 3| 0| 5| 6| 7| 4| 2| 6| 3| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    800 PPM                                | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  3  3                 2                                      2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +        +           +        +        +                     |             
      Mediastinal, Hemorrhage              |             3                    2                                       |             
      Mediastinal, Pigmentation            |             2                    2                                       |             
      Renal, Hemorrhage                    |                      3                                                   |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                  1     2              1                  |             
      Hyperplasia, Lymphoid                |                                                                   2      |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                           3              2               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      1                                                   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                  3                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +|             
      Atrophy                              |    2  1     3        2           3     3  3           2  3  2            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          | 3  4                                                                     |             
      Hyperplasia                          | 2                 3                                                      |             
      Infiltration Cellular, Histiocyte    |                                           3                       3  2   |             
      Inflammation                         |                                                                          |             
      Lactation                            |    3     2                    2     2  2           2  2     2  2  3      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |    3                    3                                                |             
      Femur, Hyperostosis                  |                2     2  3                                                |             
      Maxilla, Hyperostosis                |                               2                                          |             
      Turbinate, Hyperostosis              |                2        3                                                |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    3                 3        3                       2  3        3  2   |             
      Degeneration, Focal                  |                                  2                                       |             
      Hemorrhage                           |                                  2                                       |             
      Hydrocephalus                        |                      2        2                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 7| 9| 3| 4| 0| 3| 3| 7| 3| 6| 3| 3| 3| 3| 2|             
                                           | 5| 5| 6| 5| 5| 5| 5| 7| 5| 4| 3| 4| 6| 3| 0| 5| 6| 7| 4| 2| 6| 3| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    800 PPM                                | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Meninges, Inflammation, Focal        |                                  2                                       |             
      Meninges, Thrombosis, Focal          |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      2     3                                             |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                      1   |             
      Infiltration Cellular, Histiocyte    |       1     1  1                          3                              |             
      Inflammation                         |                                                                1         |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                                          |             
      Edema, Focal                         |                                                                          |             
      Foreign Body                         |                                                                          |             
      Inflammation                         |                                                                          |             
      Nasolacrimal Duct, Inflammation      |                                        2                                 |             
      Olfactory Epithelium, Atrophy, Focal |                                                                          |             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       | 1  1  1     3  1        2  1  2     1  1  1  1  2     2  1     3     1  1|             
      Respiratory Epithelium, Hyperplasia  | 2                                                                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                               |             
      Inflammation                         |          2                                                               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |             1                                                            |             
      Necrosis                             |                      3                                                   |             
      Nephropathy, Chronic                 | 2     1  2  1  3        2  1  2  1  2  2     1  2     2  2  2  1  1  1   |             
      Bilateral, Hydronephrosis            |                                                                          |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                1                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 8|                                                                       |            |
                                           | 6|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    800 PPM                                | 2|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A                                                                        |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Basophilic Focus                     |                                                                          |     31  1.7|
      Congestion                           |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                                                          |      3  2.0|
      Fatty Change                         |                                                                          |      4  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      4  2.3|
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  1.5|
      Inflammation                         |                                                                          |     10  1.4|
      Leukocytosis                         |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      3  2.0|
      Centrilobular, Degeneration          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   6        |
      Fat, Necrosis                        |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  51        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Inflammation                         |                                                                          |      1  2.0|
      Acinar Cell, Atrophy                 |                                                                          |     20  1.5|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Hyperplasia                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  51        |
      Hyperplasia                          |                                                                          |      3  2.3|
      Inflammation                         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  51        |
      Ulcer                                |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 8|                                                                       |            |
                                           | 6|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    800 PPM                                | 2|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       |                                                                          |     15  1.4|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Atrium, Dilatation                   |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
      Coronary Artery, Inflammation        |                                                                          |      1  3.0|
      Valve, Inflammation, Chronic         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
      Angiectasis                          |                                                                          |      6  1.3|
      Congestion                           |                                                                          |      1  2.0|
      Cytologic Alterations                |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia, Focal                   |                                                                          |      8  1.8|
      Necrosis                             |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  50        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M                                                                        |  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  50        |
      Pars Distalis, Angiectasis           |                                                                          |     10  2.9|
      Pars Distalis, Cyst                  | 2                                                                        |     16  2.4|
      Pars Distalis, Hyperplasia           |                                                                          |     13  2.0|
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      C-Cell, Hyperplasia                  |                                                                          |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                                                                        |  50        |
      Ectasia                              |                                                                          |      7  2.4|
      Hyperplasia                          | 3                                                                        |      8  2.1|
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 8|                                                                       |            |
                                           | 6|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    800 PPM                                | 2|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |  51        |
      Dilatation                           |                                                                          |      6  1.7|
      Fibrosis                             | 4                                                                        |      1  4.0|
      Hemorrhage                           |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   2        |
      Inflammation                         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  51        |
      Hyperplasia                          |                                                                          |      8  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   9        |
      Mediastinal, Hemorrhage              |                                                                          |      2  2.5|
      Mediastinal, Pigmentation            |                                                                          |      2  2.0|
      Renal, Hemorrhage                    |                                                                          |      2  2.5|
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  49        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      4  1.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  49        |
      Infiltration Cellular, Histiocyte    |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  51        |
      Hematopoietic Cell Proliferation     |                                                                          |      5  2.2|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Pigmentation                         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  47        |
      Atrophy                              |                                                                          |     23  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  50        |
      Galactocele                          |                                                                          |      3  3.7|
      Hyperplasia                          | 2                                                                        |      7  2.3|
      Infiltration Cellular, Histiocyte    |                                                                          |      3  2.7|
      Inflammation                         |                                                                          |      1  3.0|
      Lactation                            |                                                                          |     24  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 8|                                                                       |            |
                                           | 6|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    800 PPM                                | 2|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
      Cranium, Hyperostosis                |                                                                          |      3  2.7|
      Femur, Hyperostosis                  |                                                                          |      3  2.3|
      Maxilla, Hyperostosis                |                                                                          |      1  2.0|
      Turbinate, Hyperostosis              |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
      Compression                          |                                                                          |     10  2.7|
      Degeneration, Focal                  |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Hydrocephalus                        |                                                                          |      4  2.0|
      Meninges, Inflammation, Focal        |                                                                          |      1  2.0|
      Meninges, Thrombosis, Focal          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Congestion                           |                                                                          |      2  2.5|
      Hemorrhage                           |                                                                          |      3  2.3|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      7  1.3|
      Inflammation                         |                                                                          |      4  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  51        |
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Edema, Focal                         |                                                                          |      2  2.0|
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      5  1.6|
      Nasolacrimal Duct, Inflammation      |                                                                          |      3  2.0|
      Olfactory Epithelium, Atrophy, Focal |                                                                          |      2  2.0|
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       | 1                                                                        |     42  1.7|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 8|                                                                       |            |
                                           | 6|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    800 PPM                                | 2|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Infarct                              |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  3.0|
      Nephropathy, Chronic                 |                                                                          |     40  1.7|
      Bilateral, Hydronephrosis            |                                                                          |      1  4.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 0| 9| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3|             
                                           | 5| 1| 1| 5| 0| 5| 6| 4| 3| 6| 8| 4| 4| 5| 3| 3| 6| 8| 5| 3| 5| 9| 6| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1600                                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                    4                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          1     2  2           2     1  1  1  2  2     1           2     2|             
      Clear Cell Focus                     |                                  1                                       |             
      Congestion                           |                                                    2                     |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                             3            |             
      Infiltration Cellular, Lymphocyte    |                      1     1                                             |             
      Inflammation                         |                            1              1                              |             
      Leukocytosis                         |                               2                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +  +            |             
      Fat, Necrosis                        |                                                          2  3            |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                          X               |             
      Acinar Cell, Atrophy                 | 1  3  2  1  2           2              2        2  3     2  1  2  1      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1     2                                                            |             
      Ulcer                                |             3                 3                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Necrosis                             |       2                       2                                          |             
      Ulcer                                |             3                                                            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                1  2              1  2        2                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 0| 9| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3|             
                                           | 5| 1| 1| 5| 0| 5| 6| 4| 3| 6| 8| 4| 4| 5| 3| 3| 6| 8| 5| 3| 5| 9| 6| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1600                                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                     3                                    |             
      Cytoplasmic Alteration               |                               1                             2            |             
      Degeneration                         |                                                                          |             
      Hemorrhage                           |             2                                                            |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy                          |                                                       1                  |             
      Necrosis                             | 1                                                                        |             
      Vacuolization Cytoplasmic, Focal     |             2     2                    1                                 |             
      Vacuolization Cytoplasmic            |                                                                2         |             
      Capsule, Inflammation                |                            2                                             |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       2                                                                  |             
      Hyperplasia                          |                                                          1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Pars Distalis, Angiectasis           | 3                             2        3                                 |             
      Pars Distalis, Cyst                  |                      1        2              2  2  3                     |             
      Pars Distalis, Hyperplasia           | 4                    2     2     2        2                 1            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2           2                             2        1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    3        3              2  2                 2  2     2  3  2  2      |             
      Hyperplasia                          |                2                       3  2                              |             
      Inflammation                         |                   2  4                                                   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            2     3        4                              |             
      Inflammation, Granulomatous          |                                                                          |             
      Corpus Luteum, Hypertrophy           |                               3                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                      3                                1                  |             
      Hemorrhage                           |                      3                                                   |             
      Endometrium, Hyperplasia             |                                                 2                        |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation                         |                                                                          |             
      Prolapse                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 0| 9| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3|             
                                           | 5| 1| 1| 5| 0| 5| 6| 4| 3| 6| 8| 4| 4| 5| 3| 3| 6| 8| 5| 3| 5| 9| 6| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1600                                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |          3                    3                    2                     |             
      Myelofibrosis                        |                   2                                                      |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +           +  +           +              +        +     +     +   |             
      Mediastinal, Hemorrhage              |                   3  2           3              3                        |             
      Mediastinal, Pigmentation            |                   3  2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                               2                                          |             
      Hyperplasia, Plasma Cell             |                               2     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |          3                 1  3                    2                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Necrosis                             |                                                                      4   |             
      Pigmentation                         |                         3                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Atrophy                              |             3     2           1        1        2     1  2              3|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                          2     2                                   2|             
      Lactation                            |                      2        2     3  2           2           2         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tail, Fibrosis                       |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                                        2        3                        |             
      Femur, Hyperostosis                  |                                        4        2                        |             
      Turbinate, Hyperostosis              |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                   2                    2                                 |             
      Hemorrhage                           |             3                                                            |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 0| 9| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3|             
                                           | 5| 1| 1| 5| 0| 5| 6| 4| 3| 6| 8| 4| 4| 5| 3| 3| 6| 8| 5| 3| 5| 9| 6| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1600                                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Infiltration Cellular, Histiocyte    |                      1     1        1  2     1  1           1           1|             
      Inflammation                         |          1                    1  1     1  1     1     1     1     1      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                               4                       2           1      |             
      Thrombosis                           |             2                                                            |             
      Nares, Hyperplasia                   |                                                                          |             
      Nasolacrimal Duct, Inflammation      |          1                                   2                           |             
      Olfactory Epithelium, Atrophy, Focal |                                                                          |             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       | 2  2  2  1  1  3  1  2     1  2  1  2  2  1  2  2     2  2  2  2  1  2  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                    +                     |             
      Hemorrhage                           |                               4                                          |             
      Phthisis Bulbi                       |                                                    3                     |             
      Cornea, Inflammation                 |                               4                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                          |             
      Infiltration Cellular, Lymphocyte    |                               1                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       4                                                                  |             
      Inflammation                         |          1                                                               |             
      Mineralization                       |                                                                          |             
      Necrosis                             |    2                                                                 2   |             
      Nephropathy, Chronic                 | 1     2     1  3  2  2  1  2  2  2  2  3  2  1  1  1  2  2  1     1     2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 8| 3| 3| 9| 3| 6| 3| 3| 7| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 1|             
                                           | 4| 4| 4| 5| 8| 3| 4| 6| 6| 3| 1| 5| 3| 4| 6| 4| 5| 4| 5| 5| 5| 4| 6| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1600                                   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    PPM                                    | 8| 9| 0| 1| 2| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 3     3  3     2     2  2     1     1     1     2  2  1  2  2  1  1      |             
      Clear Cell Focus                     |                                              3                           |             
      Congestion                           |             2                    2                                       |             
      Developmental Malformation           |                         2                                                |             
      Eosinophilic Focus                   |                                                          2               |             
      Fatty Change                         |       2     2                 1                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         | 1        1     1        1     2                    2                     |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Fat, Necrosis                        |                                                                      3   |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |             +                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Acinar Cell, Atrophy                 |       1        1                 1     2  2  1  1  1  2  1              2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1                                                                     |             
      Ulcer                                |                   3              3           2                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                              2                           |             
      Necrosis                             |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |             +                                                            |             
      Inflammation                         |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1                 1                             1                    2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 8| 3| 3| 9| 3| 6| 3| 3| 7| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 1|             
                                           | 4| 4| 4| 5| 8| 3| 4| 6| 6| 3| 1| 5| 3| 4| 6| 4| 5| 4| 5| 5| 5| 4| 6| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1600                                   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    PPM                                    | 8| 9| 0| 1| 2| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                             1     2      |             
      Cytoplasmic Alteration               |                                                                          |             
      Degeneration                         |                      2                                                   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |    1        2  1                                                         |             
      Hypertrophy                          |                                                                          |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |       2  2  2                                   2           2            |             
      Vacuolization Cytoplasmic            |                                  1                                       |             
      Capsule, Inflammation                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  M  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                              3                           |             
      Pars Distalis, Angiectasis           |       2     3                    2                          3            |             
      Pars Distalis, Cyst                  | 2     2  3     3                       1        3  2     3        2      |             
      Pars Distalis, Hyperplasia           | 1        2     2     3                 1           2        3  2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |          2                    2  3  2        3  2  2              2  3  2|             
      Hyperplasia                          | 1  2                                            2                        |             
      Inflammation                         |                                                                   3      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      2   |             
      Inflammation, Granulomatous          |                3                                                         |             
      Corpus Luteum, Hypertrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                      3                                   2               |             
      Hemorrhage                           |                                                                          |             
      Endometrium, Hyperplasia             |                                                          2               |             
                                            __________________________________________________________________________|             
   Vagina                                  |          +                                                               |             
      Inflammation                         |          2                                                               |             
      Prolapse                             |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 8| 3| 3| 9| 3| 6| 3| 3| 7| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 1|             
                                           | 4| 4| 4| 5| 8| 3| 4| 6| 6| 3| 1| 5| 3| 4| 6| 4| 5| 4| 5| 5| 5| 4| 6| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1600                                   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    PPM                                    | 8| 9| 0| 1| 2| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         1                                                |             
      Hyperplasia                          |                      2                 2           2                    2|             
      Myelofibrosis                        |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +              +                                                  +   |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hemorrhage                           |                1        2                                                |             
      Hyperplasia, Plasma Cell             |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             3                                                           1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2                                                                        |             
      Hematopoietic Cell Proliferation     | 1                                                  2                     |             
      Hyperplasia, Lymphoid                |                                                    2                     |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |             2                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  +|             
      Atrophy                              |    2  2     3           2  2  2  1  1  2  2  3     2           2  3     3|             
      Cyst                                 |                                                                   2      |             
      Hemorrhage                           |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2        3              1        2                                       |             
      Lactation                            | 2  2        2           1     2  2     2     2                    1      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tail, Fibrosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                                                                   3      |             
      Femur, Hyperostosis                  |                                                                   2      |             
      Turbinate, Hyperostosis              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                         2     3                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 8| 3| 3| 9| 3| 6| 3| 3| 7| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 1|             
                                           | 4| 4| 4| 5| 8| 3| 4| 6| 6| 3| 1| 5| 3| 4| 6| 4| 5| 4| 5| 5| 5| 4| 6| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1600                                   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    PPM                                    | 8| 9| 0| 1| 2| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  2                                       |             
      Infiltration Cellular, Lymphocyte    |                                           1                              |             
      Infiltration Cellular, Histiocyte    |       1              1        1     1           1     1        1         |             
      Inflammation                         | 1        1  1                       1                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                2         |             
      Thrombosis                           |                                                                          |             
      Nares, Hyperplasia                   |                            4                                             |             
      Nasolacrimal Duct, Inflammation      |                                  2                                       |             
      Olfactory Epithelium, Atrophy, Focal |                                                                2         |             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       | 2  2  3  2  2  2  1  2  1  2  2  2  3  2  2  3  2  2  2  3  1  1  2  1  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                    +                                 |             
      Hemorrhage                           |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
      Cornea, Inflammation                 |                                                                          |             
      Lens, Cataract                       |                   2                    2                                 |             
      Retina, Degeneration                 |                   4                    3                                 |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                                1         |             
      Necrosis                             |                                                                          |             
      Nephropathy, Chronic                 | 2  1  2  1  2  1     2  2  2  1     1  1  2     3     1  1  2     2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 5|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    1600                                   | 7|                                                                       |      L     |
    PPM                                    | 9|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  50        |
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Basophilic Focus                     | 1                                                                        |     29  1.7|
      Clear Cell Focus                     |                                                                          |      2  2.0|
      Congestion                           |                                                                          |      3  2.0|
      Developmental Malformation           |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      1  2.0|
      Fatty Change                         |                                                                          |      3  1.7|
      Hepatodiaphragmatic Nodule           |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  1.0|
      Inflammation                         | 1                                                                        |      9  1.2|
      Leukocytosis                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Fat, Necrosis                        |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  51        |
      Accessory Spleen                     |                                                                          |      1     |
      Acinar Cell, Atrophy                 |                                                                          |     24  1.6|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  50        |
      Hyperplasia                          |                                                                          |      3  1.3|
      Ulcer                                |                                                                          |      5  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  51        |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 5|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    1600                                   | 7|                                                                       |      L     |
    PPM                                    | 9|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       |                                                                          |      9  1.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  2.0|
      Angiectasis                          |                                                                          |      3  2.0|
      Cytoplasmic Alteration               |                                                                          |      2  1.5|
      Degeneration                         |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      3  1.3|
      Hypertrophy                          |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      8  1.9|
      Vacuolization Cytoplasmic            |                                                                          |      2  1.5|
      Capsule, Inflammation                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  51        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  51        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  51        |
      Developmental Malformation           |                                                                          |      1  3.0|
      Pars Distalis, Angiectasis           |                                                                          |      7  2.6|
      Pars Distalis, Cyst                  |                                                                          |     14  2.2|
      Pars Distalis, Hyperplasia           |                                                                          |     14  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      C-Cell, Hyperplasia                  |                                                                          |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                                                                        |  51        |
      Ectasia                              |                                                                          |     20  2.3|
      Hyperplasia                          |                                                                          |      6  2.0|
      Inflammation                         |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  51        |
      Cyst                                 |                                                                          |      4  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 5|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    1600                                   | 7|                                                                       |      L     |
    PPM                                    | 9|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Corpus Luteum, Hypertrophy           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |  51        |
      Dilatation                           |                                                                          |      4  2.3|
      Hemorrhage                           |                                                                          |      1  3.0|
      Endometrium, Hyperplasia             |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  2.0|
      Prolapse                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  51        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      7  2.3|
      Myelofibrosis                        |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  11        |
      Mediastinal, Hemorrhage              |                                                                          |      4  2.8|
      Mediastinal, Pigmentation            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  49        |
      Hemorrhage                           |                                                                          |      3  1.7|
      Hyperplasia, Plasma Cell             |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  51        |
      Hemorrhage                           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  51        |
      Congestion                           |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      6  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
      Pigmentation                         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M                                                                        |  46        |
      Atrophy                              |                                                                          |     23  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  51        |
      Hyperplasia                          |                                                                          |      8  2.0|
      Lactation                            | 2                                                                        |     16  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 5|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    1600                                   | 7|                                                                       |      L     |
    PPM                                    | 9|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
      Tail, Fibrosis                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
      Cranium, Hyperostosis                |                                                                          |      3  2.7|
      Femur, Hyperostosis                  |                                                                          |      3  2.7|
      Turbinate, Hyperostosis              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
      Compression                          |                                                                          |      4  2.3|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Congestion                           |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |     15  1.1|
      Inflammation                         |                                                                          |     13  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  51        |
      Inflammation                         |                                                                          |      4  2.3|
      Thrombosis                           |                                                                          |      1  2.0|
      Nares, Hyperplasia                   |                                                                          |      1  4.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      3  1.7|
      Olfactory Epithelium, Atrophy, Focal |                                                                          |      1  2.0|
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       | 1                                                                        |     49  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  51        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   5        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Phthisis Bulbi                       |                                                                          |      1  3.0|
      Cornea, Inflammation                 |                                                                          |      1  4.0|
      Lens, Cataract                       |                                                                          |      2  2.0|
      Retina, Degeneration                 |                                                                          |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 5|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    1600                                   | 7|                                                                       |      L     |
    PPM                                    | 9|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Cyst                                 |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      2  2.0|
      Nephropathy, Chronic                 | 3                                                                        |     40  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 5| 7| 7| 7| 5| 6| 5| 7| 5| 2| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 4| 9| 2| 3| 3| 2| 8| 6| 3| 5| 0| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3|             
                                           | 4| 6| 9| 0| 3| 2| 5| 4| 7| 2| 4| 3| 9| 2| 3| 2| 6| 2| 0| 2| 2| 3| 3| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  +|             
      Diverticulum                         | 3                                                                        |             
      Inflammation, Chronic                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             1                                            2               |             
      Atrophy                              | 2                                                                        |             
      Basophilic Focus                     |    1        2                                2           2        2      |             
      Clear Cell Focus                     |             1                                                            |             
      Congestion                           |    4              3                                                      |             
      Degeneration, Cystic                 |                            2                             2  2  2  2      |             
      Developmental Malformation           |                                     2                                    |             
      Eosinophilic Focus                   |             2                                                            |             
      Fibrosis                             |                                                    2                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |    3                                                                     |             
      Hepatodiaphragmatic Nodule           |          3                                                               |             
      Mixed Cell Focus                     |             2                                                            |             
      Necrosis                             |                         3                                                |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +     +                    +     +           +  +            |             
      Fat, Necrosis                        |          3  3     3                    3                 3  2            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinar Cell, Atrophy                 |    2        2  3     2  1  1  2     2  1        3  2           2  2  2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                                                   |             
      Ulcer                                |                      2                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                      3                                                   |             
      Hyperkeratosis, Focal                |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 5| 7| 7| 7| 5| 6| 5| 7| 5| 2| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 4| 9| 2| 3| 3| 2| 8| 6| 3| 5| 0| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3|             
                                           | 4| 6| 9| 0| 3| 2| 5| 4| 7| 2| 4| 3| 9| 2| 3| 2| 6| 2| 0| 2| 2| 3| 3| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       |          2  2  2  2     2  2           2  2  2     2  2  1  2     2     3|             
      Atrium, Thrombosis                   |                                                             2     2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   2     1|             
      Cytologic Alterations                |                         1                                                |             
      Hyperplasia, Focal                   |                                                             1            |             
      Necrosis                             |                                                          2               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1  2              1           2  1           3     2  4        1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                3                                                         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  M  M  M  +  +  M  +  +  M  +|             
      Hyperplasia                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   2                                                      |             
      Pars Distalis, Angiectasis           |          2     4           3                                             |             
      Pars Distalis, Cyst                  |                                                                   1      |             
      Pars Distalis, Degeneration          |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                            3              2  2                           |             
      Pars Intermedia, Angiectasis         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                           2                             2|             
      Follicle, Dilatation                 |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypospermia                          |          4           4     4           4  4  4     4  4  4  4  4  4     4|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       4                                                                  |             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |                                     3           2                        |             
      Inflammation                         |                                        2                    2     2      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     2                                    |             
      Fibrosis, Focal                      |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |       4  3           4     4  3     2  3  2     3  4  4  4  3  4  3     3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 5| 7| 7| 7| 5| 6| 5| 7| 5| 2| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 4| 9| 2| 3| 3| 2| 8| 6| 3| 5| 0| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3|             
                                           | 4| 6| 9| 0| 3| 2| 5| 4| 7| 2| 4| 3| 9| 2| 3| 2| 6| 2| 0| 2| 2| 3| 3| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                             3        3     3                     |             
      Bilateral, Atrophy                   |                                                          3               |             
      Interstitial Cell, Hyperplasia, Focal|                         2                          2                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3                       3                                2               |             
      Erythroid Cell, Hyperplasia          |          2                                   3              2            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +                             +     +  +  +           +     +  +|             
      Mediastinal, Hemorrhage              |          2                                                               |             
      Mediastinal, Pigmentation            |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |             1                                                            |             
      Hyperplasia, Lymphoid                |          2                                                               |             
      Hyperplasia, Plasma Cell             |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                                             2            |             
      Hyperplasia, Plasma Cell             | 2                                                                        |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Developmental Malformation           |             2                                            3        1      |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 2                       3                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2        2  3  3        3  2           2  3           3  4     2  3  3|             
      Depletion Cellular                   |                                                                          |             
      Hemorrhage                           |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|             
      Hyperplasia                          |                            2                                             |             
      Lactation                            |             2  2     2              2                    3               |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hair Follicle, Atrophy               |                                                          3               |             
      Tail, Acanthosis, Focal              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Rib, Developmental Malformation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 5| 7| 7| 7| 5| 6| 5| 7| 5| 2| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 4| 9| 2| 3| 3| 2| 8| 6| 3| 5| 0| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3|             
                                           | 4| 6| 9| 0| 3| 2| 5| 4| 7| 2| 4| 3| 9| 2| 3| 2| 6| 2| 0| 2| 2| 3| 3| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
           Focal                           |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |    1                    1                    1                    1      |             
      Inflammation                         |                                                          1        2      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |             1  2                                                  1      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               |                                           2                             3|             
      Inflammation                         |                2                          3                       1     3|             
      Cartilage, Dysplasia                 |             2                                                            |             
      Goblet Cell, Hyperplasia, Focal      |                                                                          |             
      Nasolacrimal Duct, Inflammation      |                      2                                                   |             
      Nasopharyngeal Duct, Metaplasia,     |                                                                          |             
           Squamous                        |                         2                                                |             
      Olfactory Epithelium, Atrophy, Focal |                                                                          |             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       |                1                          1  1              2            |             
      Olfactory Epithelium, Degeneration   |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                         2                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
      Lens, Cataract                       |                3                                                         |             
      Retina, Degeneration                 |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  3                                       |             
      Nephropathy, Chronic                 | 1  2  2  2  3  3  2  1  2  2        2  1  2  1     1     4  1     2     1|             
      Pigmentation                         |                                                             3            |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 4| 5| 8| 3| 3|            |
                                           | 2| 0| 3| 3| 2| 1| 2| 3| 2| 2| 2| 2| 2| 5| 2| 3| 2| 3| 2| 2| 3| 7| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 0| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
      Diverticulum                         |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                            2                                             |      3  1.7|
      Atrophy                              |                                                                          |      1  2.0|
      Basophilic Focus                     | 1        2           2  2  2  1     2     2  2        1  1              2|     17  1.7|
      Clear Cell Focus                     |                      1                                                   |      2  1.0|
      Congestion                           |                                                                          |      2  3.5|
      Degeneration, Cystic                 | 1     2  2        2        1     2  2        2                          2|     14  1.9|
      Developmental Malformation           |                                     2                                    |      2  2.0|
      Eosinophilic Focus                   |       1  2  2        2                       3     3                     |      7  2.1|
      Fibrosis                             |          2           2                                                   |      3  2.0|
      Hematopoietic Cell Proliferation     |                      1                                                   |      1  1.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                               X                                          |      2  3.0|
      Mixed Cell Focus                     |                            2                                             |      2  2.0|
      Necrosis                             |                                                                          |      1  3.0|
      Thrombosis                           |                      2                                                   |      1  2.0|
      Bile Duct, Hyperplasia               |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +        +                    +                        |  10        |
      Fat, Necrosis                        |                   3        3                    3                        |      9  2.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinar Cell, Atrophy                 |       1  2  2           3  2  1  1                 3  2        2     3   |     25  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2           3                                                         |      3  2.3|
      Ulcer                                |    4                                   3                                 |      3  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Hyperkeratosis, Focal                |                3                                                         |      1  3.0|
      Necrosis                             |                                  1                                       |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 4| 5| 8| 3| 3|            |
                                           | 2| 0| 3| 3| 2| 1| 2| 3| 2| 2| 2| 2| 2| 5| 2| 3| 2| 3| 2| 2| 3| 7| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 0| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2     2  3  2        2  3     1  2  3     1  3        2  2  2  2     2  2|     32  2.1|
      Atrium, Thrombosis                   |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    1                       1  1           2                              |      6  1.3|
      Cytologic Alterations                |                                                                          |      1  1.0|
      Hyperplasia, Focal                   |                                     1        1                           |      3  1.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 1     1        1     2  1  3  3  2              2  1     3  2  1  1  2  1|     25  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +|  38        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis           |          2           3     3        2                                    |      7  2.7|
      Pars Distalis, Cyst                  |                               2                                          |      2  1.5|
      Pars Distalis, Degeneration          |                                     3                                    |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |                                                          1              2|      5  2.0|
      Pars Intermedia, Angiectasis         |                      3                                   2               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                                                             1        2   |      4  1.8|
      Follicle, Dilatation                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypospermia                          | 4  4  4  4  2     4  4  2  4  3  2  4     4        4  4  4  4  2     4  4|     33  3.7|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                3                                                         |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 4| 5| 8| 3| 3|            |
                                           | 2| 0| 3| 3| 2| 1| 2| 3| 2| 2| 2| 2| 2| 5| 2| 3| 2| 3| 2| 2| 3| 7| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 0| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Ectasia                              |    2                                                                     |      1  2.0|
      Hyperplasia                          |                                     3                                    |      3  2.7|
      Inflammation                         |             2                       2     2        2  1              3  2|     10  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                3                                                  3      |      3  2.7|
      Fibrosis, Focal                      |                                                          1               |      1  1.0|
      Hyperplasia, Focal                   |                            1  1     1                    1               |      4  1.0|
      Inflammation                         | 3           1                    1     2  2                              |      5  1.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Cellular                   |    4  3     3  4  4     2  3  3  3  3     3     3  3  4     4  3  4  4  3|     35  3.3|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      4  2.8|
      Bilateral, Atrophy                   |                3                                2                        |      3  2.7|
      Interstitial Cell, Hyperplasia, Focal|                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2                                                                       2|      5  2.4|
      Erythroid Cell, Hyperplasia          |                               2                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +        +  +        +     +     +        +           +     +  +   |  20        |
      Mediastinal, Hemorrhage              |                            2                                             |      2  2.0|
      Mediastinal, Pigmentation            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                    3                     |      1  3.0|
      Hemorrhage                           |                                           2           1                  |      3  1.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erythrophagocytosis                  |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                       2                  |      1  2.0|
      Developmental Malformation           |                            2                                             |      4  2.0|
      Fibrosis                             |             4           2                                                |      2  3.0|
      Hematopoietic Cell Proliferation     | 2                                                                        |      3  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
      Atrophy                              | 2     3     2        2  3     2     3     2  3     3  3  2           3  2|     28  2.6|
      Depletion Cellular                   |                                  3                                       |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 4| 5| 8| 3| 3|            |
                                           | 2| 0| 3| 3| 2| 1| 2| 3| 2| 2| 2| 2| 2| 5| 2| 3| 2| 3| 2| 2| 3| 7| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 0| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                       2                  |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                      2                                               2   |      3  2.0|
      Lactation                            |                                              2                       2   |      7  2.1|
      Pigmentation                         |       1                                                     2            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |          3                                                               |      1  3.0|
      Hair Follicle, Atrophy               |                                                                          |      1  3.0|
      Tail, Acanthosis, Focal              |                                           2                              |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Rib, Developmental Malformation,     |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                       1                  |      1  1.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                            1                                            1|      6  1.0|
      Inflammation                         |                                                       1              3   |      4  1.8|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |       2                                                                  |      1  2.0|
      Fungus                               |                         3                                                |      3  2.7|
      Inflammation                         |       2                 4        3     2  2                    2         |     10  2.4|
      Cartilage, Dysplasia                 |                                                                          |      1  2.0|
      Goblet Cell, Hyperplasia, Focal      |                      2                                                   |      1  2.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      1  2.0|
      Nasopharyngeal Duct, Metaplasia,     |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
      Olfactory Epithelium, Atrophy, Focal |                                        2                                 |      1  2.0|
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 4| 5| 8| 3| 3|            |
                                           | 2| 0| 3| 3| 2| 1| 2| 3| 2| 2| 2| 2| 2| 5| 2| 3| 2| 3| 2| 2| 3| 7| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 0| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Alteration                       | 1                 1                    2     1  1        2     1     1   |     12  1.3|
      Olfactory Epithelium, Degeneration   |                                              1                           |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                           2                              |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Nephropathy, Chronic                 | 1     2  3  2  2  2  2  2  3  2  2  3     2  2  1  2  2  2     2     2  2|     40  2.0|
      Pigmentation                         |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Transitional Epithelium, Hyperplasia |                            3                                             |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 2| 5| 3| 3| 3| 3| 4| 3| 3| 3| 2| 7| 3| 5| 0| 3| 3| 3| 3| 2| 3|             
                                           | 2| 3| 9| 2| 6| 1| 2| 2| 2| 2| 1| 2| 2| 2| 0| 8| 2| 8| 8| 3| 3| 2| 2| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    400  PPM                               | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 2        1  1        1  1              2                 2  2           2|             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |    2                       3                             2               |             
      Degeneration                         |       3                                                                  |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |       3                                2                 1           2   |             
      Fibrosis                             |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                         2|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Necrosis                             |                                        4                                 |             
      Thrombosis                           |                   2                                                      |             
      Bile Duct, Cyst                      |                            4                                             |             
      Bile Duct, Hyperplasia               |    3                       3                                   1         |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +           +  +  +  +  +        +     +     +  +           +     +  +|             
      Fat, Necrosis                        |    3           2  3  3  2  3        3     3     3  2           2     3  2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Liver                        |                                                                          |             
      Necrosis                             |                                                                          |             
      Acinar Cell, Atrophy                 | 2  3  2        2  1  2  1        2  2  2  3        2  1  3     2  3      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis, Focal                |                                                                          |             
      Hyperplasia                          |                                           1                          3   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1  3  1     2  2  1     1        2  2        2  2     2  2  2  2     2|             
      Mineralization, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 2| 5| 3| 3| 3| 3| 4| 3| 3| 3| 2| 7| 3| 5| 0| 3| 3| 3| 3| 2| 3|             
                                           | 2| 3| 9| 2| 6| 1| 2| 2| 2| 2| 1| 2| 2| 2| 0| 8| 2| 8| 8| 3| 3| 2| 2| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    400  PPM                               | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Dilatation                   |       3                                                                  |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         1                       1        1  2     1  2   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |          2        3           2                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                1         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2  1        1     2     2                             2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                             3            |             
      Pars Distalis, Cyst                  |                            2              2     3                        |             
      Pars Distalis, Hyperplasia, Focal    | 2  2     2  1           3           1                 1        3         |             
      Pars Nervosa, Cyst                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1                 3                                         2   |             
      Follicle, Atrophy                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      | 3                                                                        |             
      Hypoplasia                           |                                                                          |             
      Hypospermia                          |    4  4  3     4  4  4  4  4     4  4  4  4     4  4  4  4  4        4  4|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       2        2                    2  3           1  1              2   |             
      Hyperplasia                          |          3                                                               |             
      Inflammation                         | 1                                                                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Atrophy                              |                                        3                    2            |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |          1              2                                                |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Inflammation                         |                   3  2                                                   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 2| 5| 3| 3| 3| 3| 4| 3| 3| 3| 2| 7| 3| 5| 0| 3| 3| 3| 3| 2| 3|             
                                           | 2| 3| 9| 2| 6| 1| 2| 2| 2| 2| 1| 2| 2| 2| 0| 8| 2| 8| 8| 3| 3| 2| 2| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    400  PPM                               | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Depletion Cellular                   | 2  3  4        4  3  3  3  3  3  2  4  4  3  3  4  3  4  2  3     3  4  3|             
      Dilatation                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         4                 3                              |             
      Bilateral, Atrophy                   |                                                                          |             
      Interstitial Cell, Hyperplasia, Focal|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |       2              2  3                                         2      |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +                          +     +        +            |             
      Mediastinal, Hemorrhage              |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3                                                                    3   |             
      Erythrophagocytosis                  |                                                                          |             
      Infiltration Cellular, Histiocyte    |                   2                                                      |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Developmental Malformation           |    2                                                                     |             
      Fibrosis                             |    2                                                     2               |             
      Hematopoietic Cell Proliferation     |       2                                                                  |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Atrophy                              | 2  2  3  2  2     3                 1  2        2     3     2  2     3   |             
      Hemorrhage                           |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                3         |             
      Hyperplasia                          | 2                                                                        |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Tail, Inflammation                   |                                                                          |             
      Tail, Necrosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 2| 5| 3| 3| 3| 3| 4| 3| 3| 3| 2| 7| 3| 5| 0| 3| 3| 3| 3| 2| 3|             
                                           | 2| 3| 9| 2| 6| 1| 2| 2| 2| 2| 1| 2| 2| 2| 0| 8| 2| 8| 8| 3| 3| 2| 2| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    400  PPM                               | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | 2                                                                        |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       | 1                                                                        |             
      Inflammation                         |                   1              2                                       |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                     2                                    |             
      Fungus                               | 2                 2                       3                             3|             
      Inflammation                         | 2     3           3           1  2  3     3              1              3|             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       |    1     2              1                                1  1        1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  1     2  1  1  2     2  1  1  1  2  1  1  1  1     1  2  3  1  1  2  2|             
      Pigmentation                         |                   3           3           3           2                  |             
      Bilateral, Hydronephrosis            |                                                                          |             
      Glomerulus, Degeneration             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 7| 6| 7| 6| 7| 3| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 5| 5| 6| 6|            |
                             DAY ON TEST   | 8| 9| 7| 3| 8| 0| 9| 3| 2| 3| 3| 1| 3| 1| 0| 4| 7| 5| 3| 0| 0| 8| 7| 1| 5|            |
                                           | 4| 3| 9| 3| 4| 1| 5| 2| 4| 3| 6| 1| 2| 5| 7| 9| 8| 1| 3| 4| 6| 6| 4| 5| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    400  PPM                               | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|      L     |
                                           | 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation                         | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |          2     1     2     2        1     2           2        2         |     17  1.6|
      Congestion                           |                               2                                          |      1  2.0|
      Degeneration, Cystic                 |                                  2                          1            |      5  2.0|
      Degeneration                         | 3                                4                                       |      3  3.3|
      Eosinophilic Focus                   |                      2                                                   |      1  2.0|
      Fatty Change                         |                      1                                                   |      5  1.8|
      Fibrosis                             |          2                                                               |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                    2  2  X               |      3  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                1         |      1  1.0|
      Necrosis                             | 2  3                                                                     |      3  3.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Bile Duct, Cyst                      |                                                                          |      1  4.0|
      Bile Duct, Hyperplasia               |                         3        2                                       |      5  2.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +        +     +     +     +        +              +  +            |  21        |
      Fat, Necrosis                        |       4        3     2     3     3        3              3  3            |     21  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectopic Liver                        |                                                    2                     |      1  2.0|
      Necrosis                             |    2                                                                     |      1  2.0|
      Acinar Cell, Atrophy                 |    2        2  2     2  2  2  1        2     2  2           2     2     2|     29  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis, Focal                |                                                                      3   |      1  3.0|
      Hyperplasia                          |                                                          1           3   |      4  2.0|
      Ulcer                                |                                        2     2                       3   |      3  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             | 1                 2     2                                                |      3  1.7|
      Ulcer                                | 2  3                                2                                   2|      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 7| 6| 7| 6| 7| 3| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 5| 5| 6| 6|            |
                             DAY ON TEST   | 8| 9| 7| 3| 8| 0| 9| 3| 2| 3| 3| 1| 3| 1| 0| 4| 7| 5| 3| 0| 0| 8| 7| 1| 5|            |
                                           | 4| 3| 9| 3| 4| 1| 5| 2| 4| 3| 6| 1| 2| 5| 7| 9| 8| 1| 3| 4| 6| 6| 4| 5| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    400  PPM                               | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|      L     |
                                           | 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    2           2        2           2     2        2                    2|     24  1.9|
      Mineralization, Focal                |                               2                                          |      1  2.0|
      Atrium, Dilatation                   |                                                                          |      1  3.0|
      Atrium, Thrombosis                   | 3                                               4                        |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                      1   |      7  1.3|
      Hemorrhage                           |                                  2                                       |      1  2.0|
      Hyperplasia, Focal                   |                1        1  2                                             |      6  1.8|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   4              2        1        2        2           1|     12  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |                                                    2        2           2|      6  2.2|
      Pars Distalis, Hyperplasia, Focal    |          2     3                       2           2  3        2         |     14  2.1|
      Pars Nervosa, Cyst                   |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                                                                          |      3  2.0|
      Follicle, Atrophy                    |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      1  3.0|
      Hypoplasia                           |    4                                                                     |      1  4.0|
      Hypospermia                          | 4     2  4  4  2  4  4  3  4     2        4     4  3  4     4           3|     35  3.7|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |          4                                   2                           |      9  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 7| 6| 7| 6| 7| 3| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 5| 5| 6| 6|            |
                             DAY ON TEST   | 8| 9| 7| 3| 8| 0| 9| 3| 2| 3| 3| 1| 3| 1| 0| 4| 7| 5| 3| 0| 0| 8| 7| 1| 5|            |
                                           | 4| 3| 9| 3| 4| 1| 5| 2| 4| 3| 6| 1| 2| 5| 7| 9| 8| 1| 3| 4| 6| 6| 4| 5| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    400  PPM                               | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|      L     |
                                           | 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation                         |                            2        3                                    |      3  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              | 2           2                                                        4   |      5  2.6|
      Hemorrhage                           |                               2                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      2  1.5|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                   2      |      1  2.0|
      Inflammation                         | 2  1           3              2  2           2                           |      8  2.1|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Cellular                   | 3     4  3  4  2  4  4  4  3        3  4  4     4  2  4     4     3  4  3|     41  3.3|
      Dilatation                           |                               2                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                      4  2|      4  3.3|
      Bilateral, Atrophy                   |                                        3                                 |      1  3.0|
      Interstitial Cell, Hyperplasia, Focal|                         2              2     2                           |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                        3                                 |      1  3.0|
      Hyperplasia                          | 2              2                 3  3                                    |      8  2.4|
      Myeloid Cell, Hyperplasia            |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +     +     +     +     +  +           +  +  +        +     +  +   |  17        |
      Mediastinal, Hemorrhage              |                                  3                                       |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                  2                                       |      1  2.0|
      Hyperplasia, Lymphoid                |                2                                      2                  |      2  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      2  3.0|
      Erythrophagocytosis                  | 2                                                                        |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Pigmentation                         | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                            2     2                                       |      2  2.0|
      Developmental Malformation           |                                                                          |      1  2.0|
      Fibrosis                             |                                                    2                     |      3  2.0|
      Hematopoietic Cell Proliferation     | 2                                1  3                                    |      4  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 7| 6| 7| 6| 7| 3| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 5| 5| 6| 6|            |
                             DAY ON TEST   | 8| 9| 7| 3| 8| 0| 9| 3| 2| 3| 3| 1| 3| 1| 0| 4| 7| 5| 3| 0| 0| 8| 7| 1| 5|            |
                                           | 4| 3| 9| 3| 4| 1| 5| 2| 4| 3| 6| 1| 2| 5| 7| 9| 8| 1| 3| 4| 6| 6| 4| 5| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    400  PPM                               | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|      L     |
                                           | 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Histiocyte    |                                  2                                       |      1  2.0|
      Necrosis                             |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +|  41        |
      Atrophy                              | 4  4        3  2        2  2  2  3  2           3     2        2        3|     26  2.4|
      Hemorrhage                           |                                     2                                    |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Pigmentation                         |                         2                          2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |    4                                                                     |      1  4.0|
      Tail, Inflammation                   |                                                       4                  |      1  4.0|
      Tail, Necrosis                       |                                                       4                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1  2.0|
      Hemorrhage                           | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                                                                      3   |      1  3.0|
      Hemorrhage                           |                                  1                                       |      1  1.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                                     1                                    |      2  1.0|
      Inflammation                         |                                     1                 2        1         |      5  1.4|
      Leukocytosis                         |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  2.0|
      Fungus                               |                                                                          |      4  2.5|
      Inflammation                         |          2                       2                                       |     11  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 6| 7| 6| 7| 6| 7| 3| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 5| 5| 6| 6|            |
                             DAY ON TEST   | 8| 9| 7| 3| 8| 0| 9| 3| 2| 3| 3| 1| 3| 1| 0| 4| 7| 5| 3| 0| 0| 8| 7| 1| 5|            |
                                           | 4| 3| 9| 3| 4| 1| 5| 2| 4| 3| 6| 1| 2| 5| 7| 9| 8| 1| 3| 4| 6| 6| 4| 5| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    400  PPM                               | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|      L     |
                                           | 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Inflammation      |                3                                                         |      1  3.0|
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       |                         2  1           1  1  2  1           1     1  2  1|     16  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 1  2     2     1     2  1  2  2        2  3     1     2     2  2        1|     37  1.6|
      Pigmentation                         |             3     2              2                 2                     |      8  2.5|
      Bilateral, Hydronephrosis            |                               2                                          |      1  2.0|
      Glomerulus, Degeneration             |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           |                               3                                          |      1  3.0|
      Hemorrhage                           |                               2                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |          1                                                               |      1  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 7| 5| 6| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 3| 6| 3| 5| 3| 3| 6| 3| 3| 8| 3| 3| 2| 5| 8| 3| 8| 3| 3| 3| 3|             
                                           | 0| 3| 6| 2| 3| 7| 2| 8| 8| 2| 5| 4| 2| 0| 8| 3| 2| 9| 7| 2| 7| 2| 8| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    800 PPM                                | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
                                           | 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       2                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                             4            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    1     2              2  2        2  2     2           2           1  1|             
      Clear Cell Focus                     |                   2                                                      |             
      Degeneration, Cystic                 |                                                                          |             
      Degeneration                         |                                                 3                        |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |                                                                2        1|             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |       2                                                                  |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |       3                                                                  |             
      Inflammation, Chronic, Focal         |                                                                         1|             
      Necrosis                             |       3                                                                  |             
      Thrombosis                           |                                                             3  2         |             
      Bile Duct, Fibrosis                  |       3                                                                  |             
      Bile Duct, Hyperplasia               | 2              2                                   3                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +        +        +        +                    +  +  +         |             
      Fat, Necrosis                        |       4  3        3        3        3                    3  3  3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Amyloid Deposition                   |       3                                                                  |             
      Edema                                |                                                                          |             
      Infiltration Cellular, Lymphocyte    |       3                                                                  |             
      Acinar Cell, Atrophy                 | 2     3  2  2        1  2  3  1  2  1     3           2        2  2  1  2|             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       3                                                                  |             
      Atrophy                              |       3                                                                  |             
      Infiltration Cellular, Lymphocyte    |       3                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia                          |                                                 1                        |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 7| 5| 6| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 3| 6| 3| 5| 3| 3| 6| 3| 3| 8| 3| 3| 2| 5| 8| 3| 8| 3| 3| 3| 3|             
                                           | 0| 3| 6| 2| 3| 7| 2| 8| 8| 2| 5| 4| 2| 0| 8| 3| 2| 9| 7| 2| 7| 2| 8| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    800 PPM                                | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
                                           | 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |             2  1  2        2  2  2  2  2  2  3           2     2  2  1  2|             
      Atrium, Dilatation                   |                                                                          |             
      Atrium, Thrombosis                   |                                                 3     2                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                       1           1     3                       1  1|             
      Hemorrhage                           |                                           2                    1         |             
      Hyperplasia, Focal                   |                                     1     2                              |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                          2               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2           1              1                 2     2     1  2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |             3                                3                           |             
      Pars Distalis, Cyst                  |          3                                            3                  |             
      Pars Distalis, Hyperplasia, Focal    |          3                 2                 3                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                               2                                          |             
      Follicle, Dilatation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypospermia                          |    4  4  4        4  4     4  4     4     2  4  4     4  4  4  4  4  4  4|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Angiectasis                          |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Depletion Cellular                   |                                                                          |             
      Ectasia                              |                         2                                         3      |             
      Hyperplasia                          |             2                                                     2      |             
      Inflammation                         |          2                                         2                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 7| 5| 6| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 3| 6| 3| 5| 3| 3| 6| 3| 3| 8| 3| 3| 2| 5| 8| 3| 8| 3| 3| 3| 3|             
                                           | 0| 3| 6| 2| 3| 7| 2| 8| 8| 2| 5| 4| 2| 0| 8| 3| 2| 9| 7| 2| 7| 2| 8| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    800 PPM                                | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
                                           | 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                    2                     |             
      Dilatation                           |                                                                          |             
      Inflammation                         | 2              2        1                 2           2           2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   | 3  3  4  3  3     4  3  3     4  4  4  3  3  3  4  3  4  3  4  4  3  3  4|             
      Ectasia                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |       3                                                                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 3                        |             
      Interstitial Cell, Hyperplasia, Focal|                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       4                                                                  |             
      Hyperplasia                          |          1                                                           2   |             
      Necrosis                             |       4                                                                  |             
      Erythroid Cell, Hyperplasia          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +           +        +        +  +        +  +     +            |             
      Mediastinal, Hemorrhage              |                               2        3                                 |             
      Mediastinal, Pigmentation            |          3                    2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       3                                                                  |             
      Hemorrhage                           |       2                                                                  |             
      Hyperplasia, Plasma Cell             |                                     2                             2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       4                                                                  |             
      Cyst, Multiple                       |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 2                                                        2               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |       4                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +|             
      Atrophy                              | 3                       4  2              2  1           2     4  2     2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Lymphocyte    |       2                                                                  |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Lactation                            |                                                                          |             
      Pigmentation                         |                                                             2            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 7| 5| 6| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 3| 6| 3| 5| 3| 3| 6| 3| 3| 8| 3| 3| 2| 5| 8| 3| 8| 3| 3| 3| 3|             
                                           | 0| 3| 6| 2| 3| 7| 2| 8| 8| 2| 5| 4| 2| 0| 8| 3| 2| 9| 7| 2| 7| 2| 8| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    800 PPM                                | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
                                           | 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
      Tail, Necrosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |       1                                                           1      |             
      Infiltration Cellular, Lymphocyte    |       2                                                                  |             
      Inflammation                         |       1     1     2                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Foreign Body                         |                                                                          |             
      Fungus                               |                                                                   3      |             
      Inflammation                         |                         3                       2                 3      |             
      Thrombosis                           |                                                                          |             
      Glands, Dilatation, Focal            |                                                                          |             
      Nasolacrimal Duct, Inflammation      |                                                                         3|             
      Olfactory Epithelium, Atrophy, Focal |                                                                          |             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       |    1        1           1  1  2  1  1  2  2  2     1     1           2  1|             
      Respiratory Epithelium, Hyperplasia  |                                                 2                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                              |             
      Phthisis Bulbi                       |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |       2                                                                  |             
      Nephropathy, Chronic                 | 2  2  1  2  2     2  1  2  1  1     1  1     3  2     1  2  2  1        2|             
      Pigmentation                         |                      2        2           2                       3      |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 7| 5| 6| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 3| 6| 3| 5| 3| 3| 6| 3| 3| 8| 3| 3| 2| 5| 8| 3| 8| 3| 3| 3| 3|             
                                           | 0| 3| 6| 2| 3| 7| 2| 8| 8| 2| 5| 4| 2| 0| 8| 3| 2| 9| 7| 2| 7| 2| 8| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    800 PPM                                | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
                                           | 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       3                                                                  |             
      Infiltration Cellular, Lymphocyte    |       2                                                                  |             
      Inflammation                         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6|            |
                             DAY ON TEST   | 1| 2| 3| 3| 2| 3| 0| 4| 0| 3| 3| 2| 7| 3| 9| 3| 3| 5| 2| 3| 3| 1| 0| 3| 5|            |
                                           | 2| 6| 2| 3| 0| 5| 7| 6| 6| 2| 2| 6| 4| 2| 5| 2| 3| 5| 0| 2| 2| 9| 8| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    800 PPM                                | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 3| 4| 5| 6| 7| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       1  2              2  1  2        1     2  2  2        2        1   |     21  1.7|
      Clear Cell Focus                     |                2                                                         |      2  2.0|
      Degeneration, Cystic                 |                                              2                           |      1  2.0|
      Degeneration                         |                                                                          |      1  3.0|
      Developmental Malformation           |                                              2                           |      1  2.0|
      Eosinophilic Focus                   |                            2                       2                 1   |      5  1.6|
      Fatty Change                         |                                        2                                 |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                 X  3                     |      2  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  3.0|
      Thrombosis                           |             3                                            2               |      4  2.5|
      Bile Duct, Fibrosis                  |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +     +        +     +  +  +           +     +     +   |  17        |
      Fat, Necrosis                        |                   3     3              2  2  3           3     3     3   |     16  2.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                   X                                                      |      1     |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Edema                                |                      3                                                   |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Acinar Cell, Atrophy                 |    1  1  2  1        2        2        2     1  2  2     1  3     2      |     29  1.8|
      Artery, Inflammation                 |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Atrophy                              |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6|            |
                             DAY ON TEST   | 1| 2| 3| 3| 2| 3| 0| 4| 0| 3| 3| 2| 7| 3| 9| 3| 3| 5| 2| 3| 3| 1| 0| 3| 5|            |
                                           | 2| 6| 2| 3| 0| 5| 7| 6| 6| 2| 2| 6| 4| 2| 5| 2| 3| 5| 0| 2| 2| 9| 8| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    800 PPM                                | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 3| 4| 5| 6| 7| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                      4                                                   |      1  4.0|
      Hyperplasia                          |                                  2                                       |      2  1.5|
      Ulcer                                |                      4           3                                       |      2  3.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                          |      1  2.0|
      Ulcer                                |    2                                                                     |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1     2  2     2              1              2  1  2        2        1   |     25  1.8|
      Atrium, Dilatation                   |                                                    2                     |      1  2.0|
      Atrium, Thrombosis                   |             2                                      2     1               |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |          1     2        1                                   3        2   |     11  1.6|
      Hemorrhage                           |                                                          2               |      3  1.7|
      Hyperplasia, Focal                   |                                                                          |      2  1.5|
      Hypertrophy                          |                                                       2                  |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                             1            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          1                             2              1                  |     10  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                    2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |                            2                                             |      3  2.7|
      Pars Distalis, Cyst                  |                2                                                         |      3  2.7|
      Pars Distalis, Hyperplasia, Focal    |                            1                 2                           |      5  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |          2              2     1                          2              2|      6  1.8|
      Follicle, Dilatation                 |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6|            |
                             DAY ON TEST   | 1| 2| 3| 3| 2| 3| 0| 4| 0| 3| 3| 2| 7| 3| 9| 3| 3| 5| 2| 3| 3| 1| 0| 3| 5|            |
                                           | 2| 6| 2| 3| 0| 5| 7| 6| 6| 2| 2| 6| 4| 2| 5| 2| 3| 5| 0| 2| 2| 9| 8| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    800 PPM                                | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 3| 4| 5| 6| 7| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hypospermia                          | 4     4  4  4  4  4     4  4  4  4     4  4  4  4  4  4  4  4     3  4  4|     39  3.9|
                                            __________________________________________________________________________|____________|
   Penis                                   |                   +                                                      |   1        |
      Angiectasis                          |                   3                                                      |      1  3.0|
      Inflammation                         |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Depletion Cellular                   |                                           4                              |      1  4.0|
      Ectasia                              |    2                       2           2                 3               |      6  2.3|
      Hyperplasia                          |                                  3                                   2   |      4  2.3|
      Inflammation                         |                                        2     1                           |      4  1.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    3                                                                     |      2  2.5|
      Dilatation                           |                               3                                          |      1  3.0|
      Inflammation                         |                2  3                                            2         |      9  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Cellular                   | 3  2        3     3  3  3  3     4     3     3  3     4  3  4  4  3     4|     40  3.4|
      Ectasia                              |                               3           2                              |      2  2.5|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia, Focal|    2                 2                                                   |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia                          |          2        3                                3                     |      5  2.2|
      Necrosis                             |                                                                          |      1  4.0|
      Erythroid Cell, Hyperplasia          |                               2        2                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +              +              +                    +           +     +|  14        |
      Mediastinal, Hemorrhage              |                                                                          |      2  2.5|
      Mediastinal, Pigmentation            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |       2           2                                      2               |      5  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Cyst, Multiple                       |                      3                                                   |      1  3.0|
      Hemorrhage                           |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6|            |
                             DAY ON TEST   | 1| 2| 3| 3| 2| 3| 0| 4| 0| 3| 3| 2| 7| 3| 9| 3| 3| 5| 2| 3| 3| 1| 0| 3| 5|            |
                                           | 2| 6| 2| 3| 0| 5| 7| 6| 6| 2| 2| 6| 4| 2| 5| 2| 3| 5| 0| 2| 2| 9| 8| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    800 PPM                                | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 3| 4| 5| 6| 7| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                        2           3                     |      2  2.5|
      Necrosis                             |                                                       2                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  M|  41        |
      Atrophy                              | 3     2        2  3  3        3        2  4  2     3        2     2  3   |     22  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                                    2                     |      1  2.0|
      Hyperplasia                          |                   2                                                      |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                          2               |      1  2.0|
      Lactation                            |             2                 2  2                                1      |      4  1.8|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                 2                        |      1  2.0|
      Inflammation                         |                                                 2                        |      1  2.0|
      Tail, Necrosis                       | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                                                                          |      2  1.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation                         |       2        2              1                                          |      6  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                              2              3            |      2  2.5|
      Foreign Body                         |             1                                            2               |      2  1.5|
      Fungus                               |                                                                         3|      2  3.0|
      Inflammation                         |             2                       3                    2           1  3|      8  2.4|
      Thrombosis                           | 3                                                     3                  |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6|            |
                             DAY ON TEST   | 1| 2| 3| 3| 2| 3| 0| 4| 0| 3| 3| 2| 7| 3| 9| 3| 3| 5| 2| 3| 3| 1| 0| 3| 5|            |
                                           | 2| 6| 2| 3| 0| 5| 7| 6| 6| 2| 2| 6| 4| 2| 5| 2| 3| 5| 0| 2| 2| 9| 8| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    800 PPM                                | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 3| 4| 5| 6| 7| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Glands, Dilatation, Focal            |                      2                                                   |      1  2.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      1  3.0|
      Olfactory Epithelium, Atrophy, Focal |                                                    3                     |      1  3.0|
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
          Alteration                       |                1  1     1     1  2  3  1  1              1  1  2  1  2  1|     28  1.4|
      Respiratory Epithelium, Hyperplasia  |             2                 2                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +                                       |   2        |
      Phthisis Bulbi                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                2        2                                                |      2  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Nephropathy, Chronic                 |    2  1  2  2  1  2  2     1  1        3     2  1  1        1  2  1  2   |     36  1.6|
      Pigmentation                         |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                   +                                                      |   1        |
      Inflammation                         |                   3                                                      |      1  3.0|
      Transitional Epithelium, Hyperplasia |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation                         |                   3                                                      |      1  3.0|
      Transitional Epithelium, Hyperplasia |                   3                                                      |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 8| 0| 0| 3| 8| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3|             
                                           | 1| 3| 3| 7| 0| 8| 0| 5| 3| 2| 1| 3| 3| 7| 2| 1| 2| 2| 3| 2| 5| 2| 5| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1600                                   | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    PPM                                    | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 4| 6| 7| 9| 0| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                                                   3      |             
      Ulcer                                |             3                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Basophilic Focus                     |    2                    2  2     1  2     1  2  2  1  2              2   |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration                         |             4                                                            |             
      Eosinophilic Focus                   |          2                                               3               |             
      Fatty Change                         |                                                                         2|             
      Hemorrhage                           |             3                                                            |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Focal                   |                                                          2               |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Leukocytosis                         |                                                                          |             
      Mixed Cell Focus                     |                                  2                                       |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |                                                 2                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +  +        +              +     +           +   |             
      Fat, Necrosis                        |                         2  3        3              3     3           2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Liver                        |                                                          2               |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Acinar Cell, Atrophy                 | 2        4  2           1  2                       2  2     1  4  1     2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                                                  1  1         |             
      Ulcer                                |          3                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                              2              2            |             
      Ulcer                                |             3  2                             3                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2        2  2  2     2     2           1  3  2  2  2  2     3  1  1  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 8| 0| 0| 3| 8| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3|             
                                           | 1| 3| 3| 7| 0| 8| 0| 5| 3| 2| 1| 3| 3| 7| 2| 1| 2| 2| 3| 2| 5| 2| 5| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1600                                   | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    PPM                                    | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 4| 6| 7| 9| 0| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Dilatation                   |                                              3                           |             
      Atrium, Thrombosis                   |             2              2                 2                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2  2  1     1        1     1  2  2     2  1                 1     3   |             
      Hemorrhage                           |             3                                                           3|             
      Hyperplasia, Focal                   |                      2           3                                       |             
      Hypertrophy                          |                                                                          |             
      Necrosis                             |             3                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2        3                                2        2           2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    2                             4        2                              |             
      Pars Distalis, Cyst                  |                                                    2     3               |             
      Pars Distalis, Hyperplasia, Focal    |                                                       2                  |             
      Pars Nervosa, Developmental          |                                                                          |             
          Malformation                     |                                           2                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                      1                          2                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Lymphocyte                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                               +                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypospermia                          |    4     4  4  2  4     4        4  4     4  4  4  4     4  4  4  4  4  4|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |          1                                                           2   |             
      Hyperplasia                          |             3                                         3                 3|             
      Inflammation                         |    2        2        3           2                    2           2      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                              2                           |             
      Hyperplasia, Focal                   |                                           1        1                     |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   | 3  3  3  4  4  4  4  3  3        3  4  3  3  4  3  4     4  4  3  3  4  3|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 8| 0| 0| 3| 8| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3|             
                                           | 1| 3| 3| 7| 0| 8| 0| 5| 3| 2| 1| 3| 3| 7| 2| 1| 2| 2| 3| 2| 5| 2| 5| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1600                                   | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    PPM                                    | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 4| 6| 7| 9| 0| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                            3                                             |             
      Interstitial Cell, Hyperplasia, Focal|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    2                                                                     |             
      Hyperplasia                          |                                           1                              |             
      Myelofibrosis                        |                                                                          |             
      Erythroid Cell, Hyperplasia          |             2                                         2                  |             
      Myeloid Cell, Atrophy                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +           +  +        +     +        +        +     +     +     +|             
      Lumbar, Pigmentation                 |                                                                         4|             
      Mediastinal, Hemorrhage              |                                     3                                    |             
      Mediastinal, Pigmentation            |                                              2        2                  |             
      Pancreatic, Lymphocyte, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                       2                  |             
      Lymphocyte, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            3                                             |             
      Infiltration Cellular, Histiocyte    |          3                                                               |             
      Pigmentation                         |                                                          3               |             
      Lymphocyte, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    2                                                                     |             
      Fibrosis                             |                         2                                2               |             
      Hematopoietic Cell Proliferation     |             2              2                                             |             
      Pigmentation                         |                                              2                           |             
      Lymphocyte, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Atrophy                              |    2     3  4              2     2  2  4  2  3  3     3        2        2|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                 2                        |             
      Hyperplasia                          |             2                                                            |             
      Lactation                            |                                                       2                  |             
      Pigmentation                         |          2                                            1  2               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 8| 0| 0| 3| 8| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3|             
                                           | 1| 3| 3| 7| 0| 8| 0| 5| 3| 2| 1| 3| 3| 7| 2| 1| 2| 2| 3| 2| 5| 2| 5| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1600                                   | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
    PPM                                    | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 4| 6| 7| 9| 0| 1| 2| 4|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                  2                                       |             
      Hemorrhage                           |                                                                2         |             
      Cerebellum, Necrosis, Focal          |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |    1                                      1           1                  |             
      Inflammation                         |    1                    1           1                                   1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             4            |             
      Edema, Focal                         |                                                                          |             
      Fungus                               |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation                         |                         2                       1     1                  |             
      Thrombosis                           |                                                                          |             
      Olfactory Epithelium, Atrophy, Focal | 2                                      3                                 |             
      Olfactory Epithelium, Cytoplasmic    |                                                                          |             
          Alteration                       | 3  1  1  2  2  3  2  2  2  2  1  2  2  2  2  2     1  2     2  3  2  2  3|             
      Olfactory Epithelium, Necrosis, Focal|                                        1                                 |             
      Respiratory Epithelium, Cytoplasmic  |                                                                          |             
          Alteration, Focal                |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Nephropathy, Chronic                 |    2     2  1           2  2  2  2  2     2  2  2     2  1     1  1  2  3|             
      Pigmentation                         |                                        2                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                     2                 3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 3| 6| 7| 7| 7| 5| 6| 3| 7| 6| 5| 5| 5| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 0| 8| 5| 3| 2| 3| 5| 7| 5| 1| 5| 3| 5| 4| 8| 3| 8| 3| 3| 7| 3| 3| 3| 0|            |
                                           | 4| 1| 3| 9| 2| 9| 2| 0| 0| 5| 5| 9| 0| 9| 4| 3| 3| 4| 3| 3| 0| 2| 2| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1600                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
    PPM                                    | 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pigmentation                         |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                               4                                          |      1  4.0|
      Basophilic Focus                     |             2     1                       2     2     2                  |     16  1.8|
      Clear Cell Focus                     |                                                       2                  |      1  2.0|
      Degeneration                         |                               2                                          |      2  3.0|
      Eosinophilic Focus                   |             2                             2                              |      4  2.3|
      Fatty Change                         |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |             X                                                            |      1     |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                               3                                          |      1  3.0|
      Leukocytosis                         |                               2                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      1  2.0|
      Necrosis                             |                               2                                          |      1  2.0|
      Thrombosis                           |                                     3                                    |      1  3.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +     +        +        +  +  +              +     +  +     +      |  17        |
      Fat, Necrosis                        |    2        2        2        2  3  3                    3  3     3      |     15  2.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectopic Liver                        |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                               2                                          |      1  2.0|
      Acinar Cell, Atrophy                 |             2  2  1              2        2  2        1     2  2  1  1   |     22  1.9|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                2                                                         |      4  1.3|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                          |      2  2.0|
      Ulcer                                |                2                                                         |      4  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 3| 6| 7| 7| 7| 5| 6| 3| 7| 6| 5| 5| 5| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 0| 8| 5| 3| 2| 3| 5| 7| 5| 1| 5| 3| 5| 4| 8| 3| 8| 3| 3| 7| 3| 3| 3| 0|            |
                                           | 4| 1| 3| 9| 2| 9| 2| 0| 0| 5| 5| 9| 0| 9| 4| 3| 3| 4| 3| 3| 0| 2| 2| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1600                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
    PPM                                    | 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |             1  2  2                       2     2  2  2  2     1     1  2|     27  1.9|
      Atrium, Dilatation                   |                                                                          |      1  3.0|
      Atrium, Thrombosis                   | 2                                                                        |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             2     3           2                       1  2     1  1  1   |     20  1.6|
      Hemorrhage                           |                                                                          |      2  3.0|
      Hyperplasia, Focal                   |             1                                   2                       2|      5  2.0|
      Hypertrophy                          |                1                                                         |      1  1.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             2           1     2  1                                       |      9  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Angiectasis           |                                                                          |      3  2.7|
      Pars Distalis, Cyst                  |                                                                          |      2  2.5|
      Pars Distalis, Hyperplasia, Focal    |       2           2                                                      |      3  2.0|
      Pars Nervosa, Developmental          |                                                                          |            |
          Malformation                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 2                                                           2            |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                               +                                          |   1        |
      Mediastinum, Infiltration Cellular,  |                                                                          |            |
           Lymphocyte                      |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Hypospermia                          |    4     4  4  4  4     4     4  4           4  4     4  4  4  4  4  4   |     34  3.9|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 3| 6| 7| 7| 7| 5| 6| 3| 7| 6| 5| 5| 5| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 0| 8| 5| 3| 2| 3| 5| 7| 5| 1| 5| 3| 5| 4| 8| 3| 8| 3| 3| 7| 3| 3| 3| 0|            |
                                           | 4| 1| 3| 9| 2| 9| 2| 0| 0| 5| 5| 9| 0| 9| 4| 3| 3| 4| 3| 3| 0| 2| 2| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1600                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
    PPM                                    | 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Ectasia                              | 3                                                     3                  |      4  2.3|
      Hyperplasia                          |    2     3                       2        3     2     3  2           3   |     11  2.6|
      Inflammation                         |    3     2                                                  3            |      9  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      2  1.0|
      Inflammation                         |                      2                          2                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Cellular                   | 2  4     3  4  4  3  3  4     4  4  4  3        3     2  2  4  4  4  3  4|     42  3.4|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia, Focal|                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Myelofibrosis                        |                                     2                                    |      1  2.0|
      Erythroid Cell, Hyperplasia          |                               2                                          |      3  2.0|
      Myeloid Cell, Atrophy                |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +              +     +  +           +           +  +     +  +  +|  22        |
      Lumbar, Pigmentation                 |                                                                          |      1  4.0|
      Mediastinal, Hemorrhage              |                               2                                          |      2  2.5|
      Mediastinal, Pigmentation            |                                                                          |      2  2.0|
      Pancreatic, Lymphocyte, Hyperplasia  |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Plasma Cell             |                2                                                         |      2  2.0|
      Lymphocyte, Hyperplasia              |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  3.0|
      Lymphocyte, Hyperplasia              |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                               2                                          |      3  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Lymphocyte, Hyperplasia              |                               2                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 3| 6| 7| 7| 7| 5| 6| 3| 7| 6| 5| 5| 5| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 0| 8| 5| 3| 2| 3| 5| 7| 5| 1| 5| 3| 5| 4| 8| 3| 8| 3| 3| 7| 3| 3| 3| 0|            |
                                           | 4| 1| 3| 9| 2| 9| 2| 0| 0| 5| 5| 9| 0| 9| 4| 3| 3| 4| 3| 3| 0| 2| 2| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1600                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
    PPM                                    | 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|  41        |
      Atrophy                              | 3  4  3        4     3     3        3           2  3     2               |     23  2.8|
      Hemorrhage                           |                                           2                              |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Lactation                            |                                     2                                    |      2  2.0|
      Pigmentation                         |          2                    2     2                                    |      6  1.8|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Inflammation    |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Cerebellum, Necrosis, Focal          |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                            +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                                                                          |      3  1.0|
      Inflammation                         |             1     2           1                          2     1  2      |     10  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  4.0|
      Edema, Focal                         |       2                                                                  |      1  2.0|
      Fungus                               |          2                                                               |      1  2.0|
      Inflammation, Acute                  |                            3                                             |      1  3.0|
      Inflammation                         |          2                       2                                       |      5  1.6|
      Thrombosis                           |                2                                                         |      1  2.0|
      Olfactory Epithelium, Atrophy, Focal |                                                                          |      2  2.5|
      Olfactory Epithelium, Cytoplasmic    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05068-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 08/29/94  
Route: DOSED FEED                                                                                                 Time: 22:00:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 3| 6| 7| 7| 7| 5| 6| 3| 7| 6| 5| 5| 5| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 0| 8| 5| 3| 2| 3| 5| 7| 5| 1| 5| 3| 5| 4| 8| 3| 8| 3| 3| 7| 3| 3| 3| 0|            |
                                           | 4| 1| 3| 9| 2| 9| 2| 0| 0| 5| 5| 9| 0| 9| 4| 3| 3| 4| 3| 3| 0| 2| 2| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1600                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
    PPM                                    | 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Alteration                       | 3  2  1  2  2  2  2  3  2  2  2  2  2  1  2  2  1  3  2  2     2  2  2  2|     47  2.0|
      Olfactory Epithelium, Necrosis, Focal|       2                                                                  |      2  1.5|
      Respiratory Epithelium, Cytoplasmic  |                                                                          |            |
          Alteration, Focal                |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |    +                                                                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |                               2                                          |      1  2.0|
      Nephropathy, Chronic                 | 1        2  2  1  2           1     1  2  2     3     2  1     2     1  2|     32  1.8|
      Pigmentation                         |                                                    3                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
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