National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3877

TDMS Study 05069-06 Pathology Tables

                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE


NTP Experiment-Test: 05069-06                                                                                     Report: PEIRPT03
Study Type: INIT/PROMOT                                                                                           Date: 10/19/93
Route: DERMAL,SOLUTION                                                                                            Time: 13:41:28




       Facility:  TSI Mason Research

       Chemical CAS #:  147-47-7

       Lock Date:  09/17/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 011    ACETONE/ACETONE
                               Include 004    ACET/TMQ5 MG/KG
                               Include 005    ACET/TMQ10 MG/KG
                               Include 006    ACET/TMQ25 MG/KG





























a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 05069-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:41:28    
____________________________________________________________________________________________________________________________________

         SENCAR MICE FEMALE                   ACETONE/        ACET/TMQ     ACET/TMQ     ACET/TMQ                                    
                                               ACETONE         5 MG/KG      10 MG/KG     25 MG/KG                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                      30              30           30           30                                       
  Early Deaths                                                                                                                      
    Natural Death                                                  1            1            2                                       
    Moribund Sacrifice                             2                                         1                                       
  Survivors                                                                                                                         
    Terminal Sacrifice                            27              29           29           27                                       
    Natural Death                                  1                                                                                 

  Animals Examined Microscopically                30              30           30           30                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                          (30)            (30)         (30)         (30)                                     
      Angiectasis                                                              1 (3%)                                               
      Congestion                                  1 (3%)          2 (7%)       1 (3%)                                               
      Eosinophilic Focus                          1 (3%)                                                                            
      Hematopoietic Cell Proliferation            7 (23%)         4 (13%)      6 (20%)      6 (20%)                                 
      Inflammation, Chronic                                       2 (7%)       2 (7%)       1 (3%)                                  
      Necrosis                                                    2 (7%)       1 (3%)                                               
      Pigmentation                                2 (7%)                                                                            
      Periportal, Fibrosis                        1 (3%)                                                                            
   Salivary Glands                                               (1)                                                                
      Interlobular, Edema                                         1 (100%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             








                                                             Page    2                                                              
NTP Experiment-Test: 05069-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:41:28    
____________________________________________________________________________________________________________________________________

         SENCAR MICE FEMALE                   ACETONE/         ACET/TMQ     ACET/TMQ     ACET/TMQ                                   
                                               ACETONE          5 MG/KG      10 MG/KG     25 MG/KG                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                         (1)              (1)                       (1)                                     
      Cyst                                                         1 (100%)                  1 (100%)                               
      Hematocyst                                  1 (100%)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                        (1)                                        (1)                                     
      Hematopoietic Cell Proliferation            1 (100%)                                   1 (100%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                          (30)             (30)         (30)         (30)                                    
      Back, Acanthosis                                             1 (3%)       3 (10%)      1 (3%)                                 
      Back, Inflammation, Chronic                                               3 (10%)      1 (3%)                                 
      Back, Inflammation, Chronic Active                                        1 (3%)                                              
      Inguinal, Inflammation, Chronic             2 (7%)           1 (3%)       3 (10%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (1)                       (1)          (1)                                    
      Cyst                                             1 (100%)                  1 (100%)                                           
      Inflammation, Chronic Active                                                            1 (100%)                              
      Nephropathy                                      1 (100%)                                                                     

a  Number of animals examined microscopically at site and number of animals with lesion                                             



                                                             Page    3                                                              
NTP Experiment-Test: 05069-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:41:28    
____________________________________________________________________________________________________________________________________

         SENCAR MICE FEMALE              ACETONE/     ACET/TMQ     ACET/TMQ     ACET/TMQ                                   
                                          ACETONE      5 MG/KG      10 MG/KG     25 MG/KG                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Cortex, Mineralization                                        1 (100%)                                                         
      Papilla, Necrosis                   1 (100%)                                                                                   
      Renal Tubule, Degeneration, Hyaline                                        1 (100%)                                           
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             














































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