TDMS Study 05069-06 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE
NTP Experiment-Test: 05069-06 Report: PEIRPT03
Study Type: INIT/PROMOT Date: 10/19/93
Route: DERMAL,SOLUTION Time: 13:41:28
Facility: TSI Mason Research
Chemical CAS #: 147-47-7
Lock Date: 09/17/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 011 ACETONE/ACETONE
Include 004 ACET/TMQ5 MG/KG
Include 005 ACET/TMQ10 MG/KG
Include 006 ACET/TMQ25 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/93
Route: DERMAL,SOLUTION Time: 13:41:28
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SENCAR MICE FEMALE ACETONE/ ACET/TMQ ACET/TMQ ACET/TMQ
ACETONE 5 MG/KG 10 MG/KG 25 MG/KG
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DISPOSITION SUMMARY
Animals Initially In Study 30 30 30 30
Early Deaths
Natural Death 1 1 2
Moribund Sacrifice 2 1
Survivors
Terminal Sacrifice 27 29 29 27
Natural Death 1
Animals Examined Microscopically 30 30 30 30
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ALIMENTARY SYSTEM
Liver (30) (30) (30) (30)
Angiectasis 1 (3%)
Congestion 1 (3%) 2 (7%) 1 (3%)
Eosinophilic Focus 1 (3%)
Hematopoietic Cell Proliferation 7 (23%) 4 (13%) 6 (20%) 6 (20%)
Inflammation, Chronic 2 (7%) 2 (7%) 1 (3%)
Necrosis 2 (7%) 1 (3%)
Pigmentation 2 (7%)
Periportal, Fibrosis 1 (3%)
Salivary Glands (1)
Interlobular, Edema 1 (100%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/93
Route: DERMAL,SOLUTION Time: 13:41:28
____________________________________________________________________________________________________________________________________
SENCAR MICE FEMALE ACETONE/ ACET/TMQ ACET/TMQ ACET/TMQ
ACETONE 5 MG/KG 10 MG/KG 25 MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (1) (1) (1)
Cyst 1 (100%) 1 (100%)
Hematocyst 1 (100%)
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HEMATOPOIETIC SYSTEM
Spleen (1) (1)
Hematopoietic Cell Proliferation 1 (100%) 1 (100%)
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INTEGUMENTARY SYSTEM
Skin (30) (30) (30) (30)
Back, Acanthosis 1 (3%) 3 (10%) 1 (3%)
Back, Inflammation, Chronic 3 (10%) 1 (3%)
Back, Inflammation, Chronic Active 1 (3%)
Inguinal, Inflammation, Chronic 2 (7%) 1 (3%) 3 (10%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
None
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (1) (1) (1)
Cyst 1 (100%) 1 (100%)
Inflammation, Chronic Active 1 (100%)
Nephropathy 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/93
Route: DERMAL,SOLUTION Time: 13:41:28
____________________________________________________________________________________________________________________________________
SENCAR MICE FEMALE ACETONE/ ACET/TMQ ACET/TMQ ACET/TMQ
ACETONE 5 MG/KG 10 MG/KG 25 MG/KG
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URINARY SYSTEM - CONT
Cortex, Mineralization 1 (100%)
Papilla, Necrosis 1 (100%)
Renal Tubule, Degeneration, Hyaline 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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