National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3883

TDMS Study 05069-06 Pathology Tables

                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE


NTP Experiment-Test: 05069-06                                                                                     Report: PEIRPT05
Study Type: INIT/PROMOT                                                                                           Date: 10/19/93
Route: DERMAL,SOLUTION                                                                                            Time: 18:16:59




       Facility:  TSI Mason Research

       Chemical CAS #:  147-47-7

       Lock Date:  09/17/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 011    ACETONE/ACETONE
                               Include 004    ACET/TMQ5 MG/KG
                               Include 005    ACET/TMQ10 MG/KG
                               Include 006    ACET/TMQ25 MG/KG





























a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 05069-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/93    
Route: DERMAL,SOLUTION                                                                                            Time: 18:16:59    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SENCAR MICE FEMALE                  ACETONE/        ACET/TMQ     ACET/TMQ     ACET/TMQ                                     
                                             ACETONE         5 MG/KG      10 MG/KG     25 MG/KG                                     
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DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                    30              30           30           30                                        
  Early Deaths                                                                                                                      
    Natural Death                                                1            1            2                                        
    Moribund Sacrifice                           2                                         1                                        
  Survivors                                                                                                                         
    Terminal Sacrifice                          27              29           29           27                                        
    Natural Death                                1                                                                                  

  Animals Examined Microscopically              30              30           30           30                                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                        (30)            (30)         (30)         (30)                                      
      Hepatocellular Adenoma                     1 (3%)                       1 (3%)                                                
      Sarcoma Stromal, Metastatic, Uterus                                                  1 (3%)                                   
   Stomach, Forestomach                                         (1)                                                                 
      Squamous Cell Papilloma                                    1 (100%)                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
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 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
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 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                        (1)             (1)                       (1)                                       
      Sarcoma Stromal, Metastatic, Uterus                                                  1 (100%)                                 
   Uterus                                                                                 (1)                                       
      Sarcoma Stromal                                                                      1 (100%)                                 
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                                                             Page   2                                                               
NTP Experiment-Test: 05069-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/93    
Route: DERMAL,SOLUTION                                                                                            Time: 18:16:59    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SENCAR MICE FEMALE                  ACETONE/        ACET/TMQ     ACET/TMQ     ACET/TMQ                                     
                                             ACETONE         5 MG/KG      10 MG/KG     25 MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
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 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                       (1)             (1)                       (1)                                       
      Sarcoma Stromal, Metastatic, Uterus                                                  1 (100%)                                 
                                                                                                                                    
















                                                             Page   3                                                               
NTP Experiment-Test: 05069-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/93    
Route: DERMAL,SOLUTION                                                                                            Time: 18:16:59    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SENCAR MICE FEMALE                   ACETONE/      ACET/TMQ     ACET/TMQ     ACET/TMQ                                      
                                              ACETONE       5 MG/KG      10 MG/KG     25 MG/KG                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)     1                1           1           1                                          
     Total Primary Neoplasms                    1                1           1           1                                          
                                                                                                                                    
   Total Animals with Benign Neoplasms          1                1           1                                                      
     Total Benign Neoplasms                     1                1           1                                                      
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                1                                          
     Total Malignant Neoplasms                                                           1                                          
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                               1                                          
     Total Metastatic Neoplasm                                                           3                                          
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              



























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