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TDMS Study 05069-06 Pathology Tables

                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE


NTP Experiment-Test: 05069-06                                                                                     Report: PEIRPT05
Study Type: INIT/PROMOT                                                                                           Date: 10/27/93
Route: DERMAL,SOLUTION                                                                                            Time: 13:12:28




       Facility:  TSI Mason Research

       Chemical CAS #:  147-47-7

       Lock Date:  09/17/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 011    ACETONE/ACETONE
                               Include 010    ACETONE/TPA
                               Include 007    TMQ/TPA
                               Include 008    DMBA/TPA





























a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 05069-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:12:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SENCAR MICE FEMALE             ACETONE/        ACETONE/        TMQ/TPA        DMBA/TPA                                     
                                        ACETONE         TPA                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study               30              30              30             30                                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                      2               4               5             18                                        
    Natural Death                                           1                              3                                        
  Survivors                                                                                                                         
    Terminal Sacrifice                     27              25              25              9                                        
    Natural Death                           1                                                                                       

  Animals Examined Microscopically         30              30              30             30                                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                   (30)            (30)            (30)           (30)                                      
      Hepatocellular Adenoma                1 (3%)          1 (3%)          2 (7%)                                                  
      Sarcoma Stromal, Metastatic, Uterus                                                  1 (3%)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
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 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
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 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                          (1)                                                      
   Ovary                                   (1)             (2)             (1)            (7)                                       
   Uterus                                                  (1)             (1)            (5)                                       
      Sarcoma Stromal                                                                      1 (20%)                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    








                                                             Page   2                                                               
NTP Experiment-Test: 05069-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:12:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SENCAR MICE FEMALE                   ACETONE/     ACETONE/    TMQ/TPA          DMBA/TPA                                    
                                              ACETONE      TPA                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                 (1)         (2)              (1)                                      
   Lymph Node, Mandibular                                                 (2)                                                       
   Lymph Node, Mesenteric                                                 (2)                                                       
   Spleen                                        (1)                      (1)              (7)                                      
   Thymus                                                                 (1)                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                                                           (1)                                      
      Adenoma                                                                               1 (100%)                                
   Skin                                          (30)         (30)        (30)             (30)                                     
      Back, Squamous Cell Carcinoma                            1 (3%)      1 (3%)          12 (40%)                                 
      Back, Squamous Cell Carcinoma, Multiple                                               8 (27%)                                 
      Back, Squamous Cell Papilloma                            2 (7%)      3 (10%)          5 (17%)                                 
      Back, Squamous Cell Papilloma, Multiple                  1 (3%)      1 (3%)          12 (40%)                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                            (1)                                                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                1 (100%)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                                       (1)         (2)              (1)                                      
      Alveolar/Bronchiolar Carcinoma                           1 (100%)    1 (50%)                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
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                                                             Page   3                                                               
NTP Experiment-Test: 05069-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:12:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SENCAR MICE FEMALE                       ACETONE/    ACETONE/   TMQ/TPA      DMBA/TPA                                     
                                                  ACETONE     TPA                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                            (1)                    (1)                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                  *(30)       *(30)      *(30)           *(30)                                      
      Leukemia Granulocytic                                                  1 (3%)                                                   
      Lymphoma Malignant Lymphocytic                                         1 (3%)                                                   
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     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   4                                                               
NTP Experiment-Test: 05069-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:12:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SENCAR MICE FEMALE                       ACETONE/     ACETONE/          TMQ/TPA    DMBA/TPA                                        
                                                  ACETONE      TPA                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)          1             4              10            24                                          
     Total Primary Neoplasms                         1             6              10            39                                          
                                                                                                                                    
   Total Animals with Benign Neoplasms               1             3               6            17                                          
     Total Benign Neoplasms                          1             4               6            18                                          
                                                                                                                                    
   Total Animals with Malignant Neoplasms                          2               4            21                                          
     Total Malignant Neoplasms                                     2               4            21                                          
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                         1                             1                                          
     Total Metastatic Neoplasm                                     1                             1                                          
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              



























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