TDMS Study 05069-06 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE
NTP Experiment-Test: 05069-06 Report: PEIRPT05
Study Type: INIT/PROMOT Date: 10/27/93
Route: DERMAL,SOLUTION Time: 13:12:28
Facility: TSI Mason Research
Chemical CAS #: 147-47-7
Lock Date: 09/17/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 011 ACETONE/ACETONE
Include 010 ACETONE/TPA
Include 007 TMQ/TPA
Include 008 DMBA/TPA
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/27/93
Route: DERMAL,SOLUTION Time: 13:12:28
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SENCAR MICE FEMALE ACETONE/ ACETONE/ TMQ/TPA DMBA/TPA
ACETONE TPA
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DISPOSITION SUMMARY
Animals Initially in Study 30 30 30 30
Early Deaths
Moribund Sacrifice 2 4 5 18
Natural Death 1 3
Survivors
Terminal Sacrifice 27 25 25 9
Natural Death 1
Animals Examined Microscopically 30 30 30 30
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (30) (30) (30) (30)
Hepatocellular Adenoma 1 (3%) 1 (3%) 2 (7%)
Sarcoma Stromal, Metastatic, Uterus 1 (3%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (1)
Ovary (1) (2) (1) (7)
Uterus (1) (1) (5)
Sarcoma Stromal 1 (20%)
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NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/27/93
Route: DERMAL,SOLUTION Time: 13:12:28
____________________________________________________________________________________________________________________________________
SENCAR MICE FEMALE ACETONE/ ACETONE/ TMQ/TPA DMBA/TPA
ACETONE TPA
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (2) (1)
Lymph Node, Mandibular (2)
Lymph Node, Mesenteric (2)
Spleen (1) (1) (7)
Thymus (1)
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INTEGUMENTARY SYSTEM
Mammary Gland (1)
Adenoma 1 (100%)
Skin (30) (30) (30) (30)
Back, Squamous Cell Carcinoma 1 (3%) 1 (3%) 12 (40%)
Back, Squamous Cell Carcinoma, Multiple 8 (27%)
Back, Squamous Cell Papilloma 2 (7%) 3 (10%) 5 (17%)
Back, Squamous Cell Papilloma, Multiple 1 (3%) 1 (3%) 12 (40%)
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MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (100%)
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (1) (2) (1)
Alveolar/Bronchiolar Carcinoma 1 (100%) 1 (50%)
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SPECIAL SENSES SYSTEM
None
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NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/27/93
Route: DERMAL,SOLUTION Time: 13:12:28
____________________________________________________________________________________________________________________________________
SENCAR MICE FEMALE ACETONE/ ACETONE/ TMQ/TPA DMBA/TPA
ACETONE TPA
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (1) (1)
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SYSTEMIC LESIONS
Multiple Organs *(30) *(30) *(30) *(30)
Leukemia Granulocytic 1 (3%)
Lymphoma Malignant Lymphocytic 1 (3%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/27/93
Route: DERMAL,SOLUTION Time: 13:12:28
____________________________________________________________________________________________________________________________________
SENCAR MICE FEMALE ACETONE/ ACETONE/ TMQ/TPA DMBA/TPA
ACETONE TPA
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 1 4 10 24
Total Primary Neoplasms 1 6 10 39
Total Animals with Benign Neoplasms 1 3 6 17
Total Benign Neoplasms 1 4 6 18
Total Animals with Malignant Neoplasms 2 4 21
Total Malignant Neoplasms 2 4 21
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 1 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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