TDMS Study 05069-06 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE
NTP Experiment-Test: 05069-06 Report: PEIRPT05
Study Type: INIT/PROMOT Date: 10/27/93
Route: DERMAL,SOLUTION Time: 13:18:09
Facility: TSI Mason Research
Chemical CAS #: 147-47-7
Lock Date: 09/17/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 009 DMBA/ ACETONE
Include 001 DMBA/TMQ5 MG/KG
Include 002 DMBA/TMQ10 MG/KG
Include 003 DMBA/TMQ25 MG/KG
Include 008 DMBA/TPA
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/27/93
Route: DERMAL,SOLUTION Time: 13:18:09
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SENCAR MICE FEMALE DMBA/ DMBA/TMQ DMBA/TMQ DMBA/TMQ DMBA/TPA
ACETONE 5 MG/KG 10 MG/KG 25 MG/KG
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DISPOSITION SUMMARY
Animals Initially in Study 30 30 30 30 30
Early Deaths
Moribund Sacrifice 2 1 2 1 18
Natural Death 1 1 2 3
Survivors
Terminal Sacrifice 26 28 28 26 9
Natural Death 1 1
Animals Examined Microscopically 30 30 30 30 30
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ALIMENTARY SYSTEM
Liver (30) (30) (30) (30) (30)
Hemangiosarcoma 1 (3%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (3%)
Sarcoma Stromal, Metastatic, Uterus 1 (3%)
Salivary Glands (1)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (2) (1) (1) (7)
Sarcoma, Metastatic, Uncertain Primary Site 1 (100%)
Uterus (1) (5)
Sarcoma Stromal 1 (20%)
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NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/27/93
Route: DERMAL,SOLUTION Time: 13:18:09
____________________________________________________________________________________________________________________________________
SENCAR MICE FEMALE DMBA/ DMBA/TMQ DMBA/TMQ DMBA/TMQ DMBA/TPA
ACETONE 5 MG/KG 10 MG/KG 25 MG/KG
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HEMATOPOIETIC SYSTEM
Lymph Node (2) (1) (1) (1) (1)
Lymph Node, Mandibular (1) (1) (1)
Lymph Node, Mesenteric (1) (1) (1)
Spleen (2) (1) (1) (2) (7)
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INTEGUMENTARY SYSTEM
Mammary Gland (1) (1) (1)
Adenoacanthoma 1 (100%)
Adenocarcinoma 1 (100%)
Adenoma 1 (100%)
Skin (30) (30) (30) (30) (30)
Squamous Cell Carcinoma 1 (3%)
Back, Squamous Cell Carcinoma 1 (3%) 12 (40%)
Back, Squamous Cell Carcinoma, Multiple 8 (27%)
Back, Squamous Cell Papilloma 5 (17%)
Back, Squamous Cell Papilloma, Multiple 12 (40%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (1) (1)
Alveolar/Bronchiolar Carcinoma 1 (100%)
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SPECIAL SENSES SYSTEM
None
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NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/27/93
Route: DERMAL,SOLUTION Time: 13:18:09
____________________________________________________________________________________________________________________________________
SENCAR MICE FEMALE DMBA/ DMBA/TMQ DMBA/TMQ DMBA/TMQ DMBA/TPA
ACETONE 5 MG/KG 10 MG/KG 25 MG/KG
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URINARY SYSTEM
Kidney (1)
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SYSTEMIC LESIONS
Multiple Organs *(30) *(30) *(30) *(30) *(30)
Lymphoma Malignant Lymphocytic 2 (7%)
Lymphoma Malignant Mixed 1 (3%)
Lymphoma Malignant Undifferentiated Cell 1 (3%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/27/93
Route: DERMAL,SOLUTION Time: 13:18:09
____________________________________________________________________________________________________________________________________
SENCAR MICE FEMALE DMBA/ DMBA/TMQ DMBA/TMQ DMBA/TMQ DMBA/TPA
ACETONE 5 MG/KG 10 MG/KG 25 MG/KG
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TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 4 1 3 2 24
Total Primary Neoplasms 4 1 3 2 39
Total Animals with Benign Neoplasms 17
Total Benign Neoplasms 18
Total Animals with Malignant Neoplasms 4 1 3 2 21
Total Malignant Neoplasms 4 1 3 2 21
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 2 1
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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