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https://ntp.niehs.nih.gov/go/2830

TDMS Study 05069-07 Pathology Tables

                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE


NTP Experiment-Test: 05069-07                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 10/19/94
Route: DERMAL,SOLUTION                                                                                            Time: 14:11:55


                                                          65 WEEK SSAC


       Facility:  TSI Mason Research

       Chemical CAS #:  147-47-7

       Lock Date:  08/05/92

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     09/04/90 - 09/05/90

       Treatment Groups:       Include 002    0 MG/KG
                               Include 004    3.6     MG/KG
                               Include 006    6.0     MG/KG
                               Include 008    10.0    MG/KG
                               Include 001    0 MG/KG
                               Include 003    3.6     MG/KG
                               Include 005    6.0     MG/KG
                               Include 007    10.0    MG/KG
























a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 14:11:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10            9           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
  Animals Examined Microscopically                    10           10            9           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (10)         (8)          (9)          (10)                                   
      Crystals                                         1 (10%)                                                                      
      Inflammation                                     1 (10%)                                                                      
   Liver                                              (10)         (9)          (9)          (10)                                   
      Clear Cell Focus                                                           1 (11%)                                            
      Eosinophilic Focus                               3 (30%)      2 (22%)      1 (11%)                                            
      Hyperplasia                                                   1 (11%)                                                         
      Infiltration Cellular, Lymphocyte                1 (10%)      1 (11%)                                                         
   Mesentery                                          (1)                       (2)          (1)                                    
      Inflammation, Chronic Active                                               1 (50%)                                            
      Fat, Necrosis                                    1 (100%)                  2 (100%)     1 (100%)                              
   Pancreas                                           (10)         (10)         (9)          (10)                                   
      Inflammation, Chronic                                                                   1 (10%)                               
      Acinus, Atrophy                                  1 (10%)                                                                      
   Salivary Glands                                    (10)         (10)         (9)          (10)                                   
      Infiltration Cellular, Lymphocyte                3 (30%)      1 (10%)                   2 (20%)                               
   Stomach, Forestomach                               (10)         (10)         (9)          (10)                                   
      Cyst                                                                       1 (11%)                                            
   Stomach, Glandular                                 (10)         (10)         (9)          (10)                                   
      Cyst                                             1 (10%)      1 (10%)                                                         
      Inflammation, Subacute                           1 (10%)                                                                      
      Mineralization                                                             1 (11%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)         (9)          (10)                                   
      Cardiomyopathy                                   5 (50%)      6 (60%)      4 (44%)      1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 14:11:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (9)          (10)                                   
      Capsule, Accessory Adrenal Cortical Nodule                    2 (20%)                                                         
      Capsule, Hyperplasia                            10 (100%)    10 (100%)     8 (89%)     10 (100%)                              
   Islets, Pancreatic                                 (10)         (10)         (9)          (10)                                   
      Hyperplasia                                                   2 (20%)      2 (22%)                                            
   Pituitary Gland                                    (8)          (9)          (9)          (9)                                    
      Pars Distalis, Hyperplasia                                    1 (11%)      1 (11%)      1 (11%)                               
   Thyroid Gland                                      (10)         (10)         (9)          (10)                                   
      Inflammation, Chronic                                         1 (10%)                                                         
      Follicle, Hypertrophy                            2 (20%)                   2 (22%)      1 (10%)                               
      Follicular Cell, Hyperplasia                     1 (10%)      1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (9)          (10)                                   
      Cyst                                             4 (40%)      2 (20%)      2 (22%)      2 (20%)                               
      Hemorrhage                                       1 (10%)                                                                      
      Periovarian Tissue, Necrosis                     1 (10%)                                                                      
   Uterus                                             (10)         (10)         (9)          (10)                                   
      Dilatation                                                    1 (10%)                                                         
      Hyperplasia, Cystic, Glandular                   9 (90%)     10 (100%)     9 (100%)     9 (90%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (10)         (9)          (10)                                   
      Myelofibrosis                                    2 (20%)      1 (10%)      1 (11%)                                            
   Lymph Node, Mandibular                             (10)         (10)         (9)          (8)                                    
      Hyperplasia, Lymphoid                            1 (10%)                                1 (13%)                               
   Lymph Node, Mesenteric                             (10)         (9)          (8)          (10)                                   
      Hyperplasia, Lymphoid                                                                   1 (10%)                               
   Spleen                                             (10)         (10)         (9)          (10)                                   
      Hematopoietic Cell Proliferation                                           2 (22%)                                            
      Hyperplasia, Lymphoid                            1 (10%)                                1 (10%)                               
   Thymus                                             (9)          (10)         (9)          (10)                                   
      Cyst                                                                                    1 (10%)                               
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 14:11:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (10)         (10)         (9)          (10)                                   
      Mineralization                                   3 (30%)      4 (40%)      5 (56%)      5 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (9)          (10)                                   
      Hemorrhage                                       2 (20%)                   3 (33%)      3 (30%)                               
      Hyperplasia, Lymphoid                                         1 (10%)                                                         
   Nose                                               (10)         (10)         (9)          (10)                                   
      Glands, Inflammation, Acute                      6 (60%)      5 (50%)      2 (22%)      3 (30%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (9)          (10)                                   
      Infarct                                                                    1 (11%)                                            
      Infiltration Cellular, Lymphocyte                                                       1 (10%)                               
      Inflammation, Chronic                                                      1 (11%)                                            
      Metaplasia, Osseous                                                        2 (22%)                                            
      Nephropathy                                      4 (40%)      3 (30%)      4 (44%)      4 (40%)                               
      Cortex, Mineralization                           3 (30%)      2 (20%)      3 (33%)      1 (10%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 14:11:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Basophilic Focus                                 1 (10%)                                                                      
      Clear Cell Focus                                 1 (10%)      2 (20%)                                                         
      Congestion                                                                 1 (10%)                                            
      Eosinophilic Focus                                                                      1 (10%)                               
      Fatty Change                                     5 (50%)      5 (50%)      5 (50%)      6 (60%)                               
      Hematopoietic Cell Proliferation                 2 (20%)                                                                      
      Hyperplasia                                                                1 (10%)                                            
      Infarct                                          1 (10%)                                                                      
      Mixed Cell Focus                                              1 (10%)                                                         
   Mesentery                                                                                 (2)                                    
      Fat, Necrosis                                                                           2 (100%)                              
   Pancreas                                           (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic                                         1 (10%)                                                         
      Inflammation, Chronic Active                                                            1 (10%)                               
      Acinus, Atrophy                                                            2 (20%)      1 (10%)                               
      Acinus, Necrosis                                 1 (10%)                                                                      
   Salivary Glands                                    (10)         (10)         (10)         (10)                                   
      Infiltration Cellular, Lymphocyte                             1 (10%)                                                         
      Mineralization                                                                          1 (10%)                               
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Cyst                                                                       1 (10%)                                            
   Stomach, Glandular                                 (10)         (10)         (10)         (10)                                   
      Cyst                                                          3 (30%)      1 (10%)                                            
      Infiltration Cellular, Polymorphonuclear         1 (10%)                                                                      
      Mineralization                                                1 (10%)      1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)         (10)         (10)                                   
      Cardiomyopathy                                   4 (40%)      4 (40%)      2 (20%)      6 (60%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 14:11:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (9)                                    
      Cytoplasmic Alteration                           1 (10%)      1 (10%)      3 (30%)      3 (33%)                               
      Hyperplasia                                      1 (10%)                                                                      
      Capsule, Hyperplasia                             8 (80%)     10 (100%)     8 (80%)      8 (89%)                               
   Islets, Pancreatic                                 (10)         (10)         (10)         (10)                                   
      Hyperplasia                                      5 (50%)      4 (40%)      5 (50%)      2 (20%)                               
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Pars Distalis, Cyst                                                                     2 (20%)                               
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Ultimobranchial Cyst                                                                    1 (10%)                               
      Follicle, Hypertrophy                            2 (20%)      1 (10%)                   1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (10)         (10)         (10)         (9)                                    
      Dilatation                                       1 (10%)                   5 (50%)      3 (33%)                               
      Inflammation, Chronic                                         2 (20%)      4 (40%)                                            
   Prostate                                           (10)         (9)          (10)         (10)                                   
      Concretion                                                    1 (11%)      1 (10%)                                            
   Testes                                             (10)         (10)         (10)         (10)                                   
      Mineralization                                                1 (10%)                                                         
      Seminiferous Tubule, Atrophy                                  1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Thymus                                             (10)         (9)          (10)         (9)                                    
      Cyst                                                          3 (33%)      1 (10%)                                            
      Ectopic Parathyroid Gland                                                               1 (11%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)                                   
      Hyperplasia, Mast Cell                           1 (10%)                                                                      
      Skin, Site of Application, Acanthosis                                                   1 (10%)                               
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 14:11:55  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (10)         (10)         (10)         (9)                                    
      Mineralization                                   4 (40%)      8 (80%)      4 (40%)      6 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Hemorrhage                                       2 (20%)                   1 (10%)                                            
      Metaplasia, Osseous                                           1 (10%)                                                         
   Nose                                               (10)         (10)         (10)         (10)                                   
      Glands, Inflammation, Acute                      1 (10%)      3 (30%)      3 (30%)      3 (30%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Hydronephrosis                                                1 (10%)                                                         
      Infiltration Cellular, Lymphocyte                             1 (10%)                                                         
      Nephropathy                                     10 (100%)    10 (100%)    10 (100%)    10 (100%)                              
      Cortex, Mineralization                          10 (100%)    10 (100%)    10 (100%)    10 (100%)                              
      Renal Tubule, Hyperplasia                                     1 (10%)                                                         
   Urinary Bladder                                    (10)         (10)         (10)         (10)                                   
      Calculus Gross Observation                       1 (10%)                                1 (10%)                               
      Calculus Micro Observation Only                                                         1 (10%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
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                             ----------              END OF REPORT             ----------                                           
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