National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2840

TDMS Study 05069-07 Pathology Tables

                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE


NTP Experiment-Test: 05069-07                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 10/19/94
Route: DERMAL,SOLUTION                                                                                            Time: 16:12:20


                                                           CORE STUDY


       Facility:  TSI Mason Research

       Chemical CAS #:  147-47-7

       Lock Date:  08/05/92

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 002    0 MG/KG
                               Include 004    3.6     MG/KG
                               Include 006    6.0     MG/KG
                               Include 008    10.0    MG/KG
                               Include 001    0 MG/KG
                               Include 003    3.6     MG/KG
                               Include 005    6.0     MG/KG
                               Include 007    10.0    MG/KG























a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1
NTP Experiment-Test: 05069-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 16:12:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 6            7            7            6                                     
    Natural Death                                     10            3            3            4                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           40           40           40                                     
  Animals Examined Microscopically                    50           50           51           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (43)         (47)         (48)         (45)                                   
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
   Intestine Large, Colon                             (49)         (50)         (51)         (49)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
   Intestine Large, Rectum                            (49)         (50)         (51)         (49)                                   
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
   Intestine Large, Cecum                             (49)         (49)         (50)         (49)                                   
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
   Intestine Small, Duodenum                          (45)         (49)         (50)         (49)                                   
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Small, Jejunum                           (44)         (47)         (51)         (49)                                   
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
   Intestine Small, Ileum                             (45)         (49)         (49)         (48)                                   
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
   Liver                                              (50)         (50)         (51)         (50)                                   
      Cholangiocarcinoma                                                                      1 (2%)                                
      Hemangiosarcoma                                  1 (2%)       1 (2%)                    1 (2%)                                
      Hemangiosarcoma, Multiple                        1 (2%)                                                                       
      Hepatocellular Carcinoma                        12 (24%)      8 (16%)      5 (10%)     11 (22%)                               
      Hepatocellular Carcinoma, Multiple               1 (2%)                    1 (2%)       2 (4%)                                
      Hepatocellular Adenoma                          21 (42%)      8 (16%)     13 (25%)     11 (22%)                               
      Hepatocellular Adenoma, Multiple                 9 (18%)     14 (28%)      8 (16%)      7 (14%)                               
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Mesentery                                          (9)          (8)          (11)         (8)                                    
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (13%)                               
      Hemangioma                                                    1 (13%)                                                         
                                                             Page   2                                                               
NTP Experiment-Test: 05069-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 16:12:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (9%)                                             
      Histiocytic Sarcoma                              1 (11%)                                                                      
   Pancreas                                           (50)         (50)         (51)         (50)                                   
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                              2 (4%)                                 1 (2%)                                
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Salivary Glands                                    (50)         (49)         (51)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (51)         (50)                                   
      Squamous Cell Papilloma                          1 (2%)                                 1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (51)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (51)         (50)                                   
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Hemangiosarcoma                                  1 (2%)                                 1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (48)         (49)         (51)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
      Capsule, Adenoma                                 1 (2%)                                 1 (2%)                                
      Capsule, Hepatocellular Carcinoma,                                                                                            
          Metastatic, Liver                                                      1 (2%)                                             
   Adrenal Medulla                                    (48)         (49)         (49)         (50)                                   
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (50)         (51)         (50)                                   
      Adenoma                                          1 (2%)                    1 (2%)       1 (2%)                                
   Pituitary Gland                                    (44)         (48)         (47)         (45)                                   
      Pars Distalis, Adenoma                           5 (11%)      4 (8%)       6 (13%)      4 (9%)                                
      Pars Distalis, Carcinoma                                      1 (2%)                                                          
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      C-Cell, Adenoma                                  1 (2%)                                                                       
      C-Cell, Carcinoma                                1 (2%)                                                                       
                                                             Page   3                                                               
NTP Experiment-Test: 05069-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 16:12:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Follicular Cell, Adenoma                                      1 (2%)       2 (4%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (49)         (50)         (49)                                   
      Carcinoma                                        1 (2%)                                                                       
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Cystadenoma                                      1 (2%)                    2 (4%)                                             
      Granulosa Cell Tumor Benign                                   1 (2%)                                                          
      Hemangioma                                                                 1 (2%)                                             
      Histiocytic Sarcoma                              2 (4%)                                 1 (2%)                                
      Thecoma Malignant                                             1 (2%)                                                          
   Uterus                                             (50)         (50)         (51)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
      Polyp Stromal                                                 2 (4%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (51)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
   Lymph Node                                         (8)          (4)          (5)          (3)                                    
      Sarcoma, Metastatic, Skin                                                               1 (33%)                               
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (13%)                                1 (33%)                               
      Pancreatic, Hemangioma                                        1 (25%)                                                         
      Pancreatic, Sarcoma, Metastatic, Skin            1 (13%)                                                                      
   Lymph Node, Mandibular                             (50)         (49)         (51)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland                                                  1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
   Lymph Node, Mesenteric                             (47)         (48)         (51)         (50)                                   
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Hemangioma                                                    1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                              2 (4%)                                 1 (2%)                                
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Spleen                                             (50)         (50)         (51)         (50)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)       2 (4%)                                             
      Histiocytic Sarcoma                              2 (4%)                                 1 (2%)                                
                                                             Page   4                                                               
NTP Experiment-Test: 05069-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 16:12:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (45)         (46)         (48)         (49)                                   
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
      Thymoma Malignant                                                          1 (2%)                                             
      Mediastinum, Carcinoma, Metastatic, Kidney       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (48)         (50)         (49)                                   
      Carcinoma                                                     1 (2%)                    1 (2%)                                
   Skin                                               (50)         (50)         (51)         (50)                                   
      Sarcoma                                                       1 (2%)                                                          
      Skin, Site of Application, Keratoacanthoma                                              1 (2%)                                
      Subcutaneous Tissue, Hemangioma                               1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     2 (4%)                    2 (4%)       1 (2%)                                
      Subcutaneous Tissue, Schwannoma Malignant                     1 (2%)                                                          
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Sarcoma                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (51)         (50)                                   
      Vertebra, Hemangiosarcoma                                                  1 (2%)                                             
   Skeletal Muscle                                    (3)          (1)          (1)          (1)                                    
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (100%)                              
      Hemangiosarcoma                                               1 (100%)                                                        
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (100%)                                           
      Sarcoma, Metastatic, Skin                        1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (51)         (50)                                   
      Carcinoma, Metastatic, Pituitary Gland                        1 (2%)                                                          
   Spinal Cord                                        (1)                       (2)          (1)                                    
      Hemangiosarcoma                                  1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   5                                                               
NTP Experiment-Test: 05069-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 16:12:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (51)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                  3 (6%)       6 (12%)      2 (4%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       2 (4%)                                                          
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       2 (4%)       2 (4%)       2 (4%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                                                1 (2%)                                
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)       1 (2%)                                
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Hemangiosarcoma, Metastatic, Heart               1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)       6 (12%)      2 (4%)       9 (18%)                               
      Hepatocellular Carcinoma, Metastatic, Lung       1 (2%)                                                                       
      Histiocytic Sarcoma                              2 (4%)                                 1 (2%)                                
      Mediastinum, Hemangiosarcoma                                               1 (2%)                                             
   Nose                                               (50)         (49)         (51)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (1)          (3)          (1)                                    
      Adenoma                                                       1 (100%)     2 (67%)                                            
      Carcinoma                                                                  1 (33%)      1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (51)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Histiocytic Sarcoma                              2 (4%)                                 1 (2%)                                
      Renal Tubule, Carcinoma                          1 (2%)                                                                       
   Urinary Bladder                                    (50)         (50)         (51)         (49)                                   
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(51)        *(50)                                   
      Histiocytic Sarcoma                              4 (8%)                                 1 (2%)                                
      Lymphoma Malignant                              10 (20%)      9 (18%)     13 (25%)      9 (18%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05069-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 16:12:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          40          41          39                                       
     Total Primary Neoplasms                           85          69          74          64                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 34          30          29          24                                       
     Total Benign Neoplasms                            43          41          43          32                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              31          22          26          28                                       
     Total Malignant Neoplasms                         42          28          31          32                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              7           7           4          13                                       
     Total Metastatic Neoplasm                         21           9          16          26                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05069-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 16:12:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6            8            2           10                                     
    Moribund Sacrifice                                 5            4            7            3                                     
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           37           41           37                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
   Gallbladder                                        (46)         (46)         (47)         (41)                                   
      Carcinoma, Metastatic, Pancreas                                            1 (2%)                                             
   Intestine Large, Colon                             (48)         (48)         (50)         (49)                                   
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (2%)                                
   Intestine Large, Cecum                             (48)         (50)         (50)         (46)                                   
      Carcinoma                                                                  1 (2%)                                             
   Intestine Small, Duodenum                          (47)         (45)         (49)         (46)                                   
   Intestine Small, Jejunum                           (47)         (46)         (49)         (45)                                   
   Intestine Small, Ileum                             (45)         (46)         (47)         (44)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (2%)                                
      Hemangiosarcoma                                  2 (4%)       3 (6%)       2 (4%)                                             
      Hemangiosarcoma, Multiple                        1 (2%)       1 (2%)                    1 (2%)                                
      Hepatoblastoma                                                1 (2%)       2 (4%)                                             
      Hepatocellular Carcinoma                         5 (10%)      7 (14%)      5 (10%)      9 (18%)                               
      Hepatocellular Carcinoma, Multiple               3 (6%)                                 4 (8%)                                
      Hepatocellular Adenoma                          14 (28%)     17 (34%)     12 (24%)     16 (32%)                               
      Hepatocellular Adenoma, Multiple                10 (20%)     13 (26%)     13 (26%)     10 (20%)                               
      Hepatocholangiocarcinoma                                                   1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Mesentery                                          (1)                       (2)          (3)                                    
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (33%)                               
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (50%)                                            
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (33%)                               
   Pancreas                                           (49)         (49)         (50)         (49)                                   
      Carcinoma                                                                  1 (2%)                                             
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (2%)                                
      Hemangioma                                                                 1 (2%)                                             
                                                             Page   8                                                               
NTP Experiment-Test: 05069-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 16:12:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Salivary Glands                                    (50)         (49)         (50)         (50)                                   
   Stomach, Forestomach                               (49)         (50)         (50)         (48)                                   
      Squamous Cell Carcinoma                          2 (4%)       1 (2%)                    1 (2%)                                
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (48)         (50)         (50)         (48)                                   
      Carcinoid Tumor Benign                                                     1 (2%)                                             
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Hemangioma                                       1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (49)         (49)         (50)                                   
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (2%)                                
      Capsule, Adenoma                                                           3 (6%)       1 (2%)                                
   Adrenal Medulla                                    (48)         (49)         (49)         (50)                                   
      Pheochromocytoma Benign                          1 (2%)                    1 (2%)                                             
   Pituitary Gland                                    (45)         (43)         (40)         (46)                                   
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      Follicular Cell, Adenoma                                                   2 (4%)       1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Pancreas                                            1 (2%)                                             
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Preputial Gland                                    (48)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
   Prostate                                           (49)         (50)         (50)         (50)                                   
                                                             Page   9                                                               
NTP Experiment-Test: 05069-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 16:12:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (2%)                                
   Seminal Vesicle                                    (49)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Pancreas                                            1 (2%)                                             
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (2%)                                
   Testes                                             (49)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Pancreas                                            1 (2%)                                             
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
      Interstitial Cell, Adenoma                       1 (2%)       1 (2%)       1 (2%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (50)         (49)                                   
      Hemangiosarcoma                                  2 (4%)       1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node                                         (2)          (3)          (1)          (2)                                    
      Pancreatic, Histiocytic Sarcoma                                                         1 (50%)                               
   Lymph Node, Mandibular                             (49)         (48)         (49)         (48)                                   
   Lymph Node, Mesenteric                             (48)         (47)         (50)         (47)                                   
      Carcinoma, Metastatic, Pancreas                                            1 (2%)                                             
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (2%)                                
      Hemangiosarcoma                                                                         1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Spleen                                             (48)         (49)         (49)         (50)                                   
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (2%)                                
      Hemangiosarcoma                                  2 (4%)       2 (4%)                    1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Thymus                                             (39)         (42)         (46)         (40)                                   
      Thymoma NOS                                      1 (3%)                                                                       
      Mediastinum, Hemangioma                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Sarcoma                                                                                 1 (2%)                                
      Subcutaneous Tissue, Sarcoma                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05069-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 16:12:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (50)         (49)                                   
      Osteosarcoma                                                                            1 (2%)                                
   Skeletal Muscle                                                 (1)                       (3)                                    
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (33%)                               
      Hemangioma                                                                              1 (33%)                               
      Hemangiosarcoma                                               1 (100%)                                                        
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     8 (16%)      7 (14%)     11 (22%)      8 (16%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           4 (8%)       1 (2%)                    2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                   6 (12%)      5 (10%)      7 (14%)      6 (12%)                               
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
      Carcinoma, Metastatic, Pancreas                                            1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       1 (2%)       2 (4%)       6 (12%)                               
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
   Trachea                                            (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (5)          (5)          (3)                                    
      Adenoma                                          3 (75%)      5 (100%)     3 (60%)      1 (33%)                               
      Carcinoma                                                                  1 (20%)      1 (33%)                               
      Bilateral, Carcinoma                                                                    1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                             2 (4%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
                                                             Page  11                                                               
NTP Experiment-Test: 05069-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 16:12:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Renal Tubule, Adenoma                                         1 (2%)       1 (2%)                                             
      Renal Tubule, Carcinoma                          1 (2%)       1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (50)         (46)                                   
      Hemangioma                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
      Lymphoma Malignant                               3 (6%)       5 (10%)      2 (4%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 05069-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 16:12:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            42          41          43          46                                       
     Total Primary Neoplasms                           74          76          75          79                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 35          33          35          34                                       
     Total Benign Neoplasms                            43          46          51          43                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          24          20          28                                       
     Total Malignant Neoplasms                         30          30          24          36                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1           3           8                                       
     Total Metastatic Neoplasm                          2           1           9          31                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                   1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.