TDMS Study 05069-07 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE
NTP Experiment-Test: 05069-07 Report: PEIRPT05
Study Type: CHRONIC Date: 10/19/94
Route: DERMAL,SOLUTION Time: 14:33:16
65 WEEK SSAC
Facility: TSI Mason Research
Chemical CAS #: 147-47-7
Lock Date: 08/05/92
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 09/04/90 - 09/05/90
Treatment Groups: Include 002 0 MG/KG
Include 004 3.6 MG/KG
Include 006 6.0 MG/KG
Include 008 10.0 MG/KG
Include 001 0 MG/KG
Include 003 3.6 MG/KG
Include 005 6.0 MG/KG
Include 007 10.0 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05069-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 14:33:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 3.6 6.0 10.0
MG/KG MG/KG MG/KG
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DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 9 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 9 10
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ALIMENTARY SYSTEM
Liver (10) (9) (9) (10)
Hepatocellular Adenoma 1 (10%) 2 (22%) 1 (11%) 1 (10%)
Hepatocellular Adenoma, Multiple 1 (10%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Medulla (10) (10) (9) (10)
Pheochromocytoma Benign 1 (10%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (10) (9) (10)
Cystadenoma 1 (10%)
Uterus (10) (10) (9) (10)
Polyp Stromal 1 (10%)
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Page 2
NTP Experiment-Test: 05069-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 14:33:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 3.6 6.0 10.0
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
Page 3
NTP Experiment-Test: 05069-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 14:33:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 3.6 6.0 10.0
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 2 4 1 1
Total Primary Neoplasms 2 5 1 1
Total Animals with Benign Neoplasms 2 4 1 1
Total Benign Neoplasms 2 5 1 1
Total Animals with Malignant Neoplasms
Total Malignant Neoplasms
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 4
NTP Experiment-Test: 05069-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 14:33:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 3.6 6.0 10.0
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hepatocellular Carcinoma 2 (20%) 2 (20%) 1 (10%)
Hepatocellular Adenoma 3 (30%) 2 (20%) 1 (10%) 2 (20%)
Hepatocellular Adenoma, Multiple 1 (10%)
Ito Cell Tumor Malignant 1 (10%)
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CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Thyroid Gland (10) (10) (10) (10)
Follicular Cell, Adenoma 1 (10%)
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GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 05069-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 14:33:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 3.6 6.0 10.0
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Alveolar/Bronchiolar Adenoma 1 (10%) 2 (20%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
Page 6
NTP Experiment-Test: 05069-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 14:33:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 3.6 6.0 10.0
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 6 5 2 5
Total Primary Neoplasms 7 5 2 6
Total Animals with Benign Neoplasms 5 2 2 5
Total Benign Neoplasms 5 2 2 5
Total Animals with Malignant Neoplasms 2 3 1
Total Malignant Neoplasms 2 3 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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