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TDMS Study 05069-07 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: TSI Mason Research                      1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)                    DATE: 04/03/96       
EXPERIMENT: 05069 TEST: 07                                                                                     TIME: 03:22:23       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-95256                              ROUTE: DERMAL,SOLUTION                                         NTP C#: 60902D       
PATHOLOGIST: DR. VOELKER                                                                                       CAS: 147-47-7        
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: TSI Mason Research                      1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)                    DATE: 04/03/96       
EXPERIMENT: 05069 TEST: 07                                                                                     TIME: 03:22:23       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-95256                              ROUTE: DERMAL,SOLUTION                                         NTP C#: 60902D       
PATHOLOGIST: DR. VOELKER                                                                                       CAS: 147-47-7        




                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    

                                                    ----------------

                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: TSI Mason Research                      1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)                    DATE: 04/03/96       
EXPERIMENT: 05069 TEST: 07                                                                                     TIME: 03:22:23       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-95256                              ROUTE: DERMAL,SOLUTION                                         NTP C#: 60902D       
PATHOLOGIST: DR. VOELKER                                                                                       CAS: 147-47-7        




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                             IN THE ANALYSIS OF THE STUDY OF 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

              ====================================================================================================

                                                           MALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Skin                          Sarcoma

              ====================================================================================================

                                                           FEMALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Liver                         Hepatocellular Adenoma
                                            Hepatocellular Carcinoma
                                            Hepatocellular Carcinoma or Hepatoblastoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Thyroid Gland: C-Cell         Carcinoma or Adenoma
              Thyroid Gland: Follicular Cell
                                            Adenoma
                                            Carcinoma or Adenoma
              All Organs                    Histiocytic Sarcoma
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors

              ====================================================================================================
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE   1
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/59 (0%)    0/59 (0%)    3/59 (5%)    1/59 (2%)  |  2/58 (3%)    0/59 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         7.3%         2.7%      |   6.1%         0.0%         0.0%         2.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)   |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    0/37 (0%)    3/41 (7%)    1/37 (3%)  |  2/33 (6%)    0/39 (0%)    0/40 (0%)    1/40 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          729 (T)      729 (T)   |   736 (T)      ---          ---          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.180        (e)        P=0.130      P=0.490    |  P=0.269N     P=0.202N     P=0.197N     P=0.433N   |
|INCIDENTAL TUMOR       |  P=0.180        (e)        P=0.130      P=0.490    |  P=0.269N     P=0.202N     P=0.197N     P=0.433N   |
|LOGISTIC REGRESSION    |  P=0.180        (e)        P=0.130      P=0.490    |  P=0.269N     P=0.202N     P=0.197N     P=0.433N   |
|COCHRAN-ARMITAGE       |  P=0.187                                           |  P=0.304N                                          |
|FISHER EXACT           |                 (e)        P=0.122      P=0.500    |               P=0.244N     P=0.239N     P=0.487N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/57 (2%)    0/58 (0%)    1/59 (2%)    0/59 (0%)  |  2/58 (3%)    1/59 (2%)    0/58 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   2.6%         0.0%         2.4%         0.0%      |   5.5%         1.7%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/9 (0%)     0/9 (0%)     0/10 (0%)    0/9 (0%)   |  0/10 (0%)    1/10 (10%)   0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  1/39 (3%)    0/37 (0%)    1/41 (2%)    0/37 (0%)  |  1/33 (3%)    0/39 (0%)    0/38 (0%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      ---          729 (T)      ---       |   711          455 (I)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.356N     P=0.510N     P=0.751N     P=0.510N   |  P=0.066N     P=0.478N     P=0.217N     P=0.214N   |
|INCIDENTAL TUMOR       |  P=0.356N     P=0.510N     P=0.751N     P=0.510N   |  P=0.099N     P=0.569N     P=0.305N     P=0.298N   |
|LOGISTIC REGRESSION    |  P=0.356N     P=0.510N     P=0.751N     P=0.510N   |  P=0.068N     P=0.495N     P=0.234N     P=0.223N   |
|COCHRAN-ARMITAGE       |  P=0.344N                                          |  P=0.069N                                          |
|FISHER EXACT           |               P=0.496N     P=0.743N     P=0.491N   |               P=0.494N     P=0.248N     P=0.239N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE   2
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/59 (3%)    1/59 (2%)    0/60 (0%)    1/59 (2%)  |  1/60 (2%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   4.4%         2.6%         0.0%         2.5%      |   2.9%         0.0%         2.3%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    0/37 (0%)    0/41 (0%)    0/37 (0%)  |  0/34 (0%)    0/40 (0%)    0/40 (0%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |   592          710          ---          691       |   729          ---          709          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.294N     P=0.521N     P=0.247N     P=0.527N   |  P=0.335N     P=0.473N     P=0.735N     P=0.473N   |
|INCIDENTAL TUMOR       |  P=0.181N     P=0.523N     P=0.260N     P=0.416N   |  P=0.549N     P=0.674N     P=0.556      P=0.674N   |
|LOGISTIC REGRESSION    |  P=0.279N     P=0.506N     P=0.236N     P=0.500N   |  P=0.347N     P=0.495N     P=0.759N     P=0.492N   |
|COCHRAN-ARMITAGE       |  P=0.280N                                          |  P=0.352N                                          |
|FISHER EXACT           |               P=0.500N     P=0.244N     P=0.500N   |               P=0.500N     P=0.752N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    5/60 (8%)    3/60 (5%)    1/60 (2%)  |  0/60 (0%)    1/60 (2%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |   7.1%        12.4%         6.6%         2.7%      |   0.0%         2.5%         4.8%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  2/39 (5%)    3/37 (8%)    1/41 (2%)    1/37 (3%)  |  0/34 (0%)    1/40 (3%)    1/40 (3%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |   592          540          553          729 (T)   |   ---          736 (T)      726          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.215N     P=0.329      P=0.650N     P=0.331N   |  P=0.590      P=0.532      P=0.278        (e)      |
|INCIDENTAL TUMOR       |  P=0.153N     P=0.444      P=0.623      P=0.382N   |  P=0.495      P=0.532      P=0.162        (e)      |
|LOGISTIC REGRESSION    |  P=0.217N     P=0.335      P=0.655      P=0.311N   |  P=0.567      P=0.532      P=0.248        (e)      |
|COCHRAN-ARMITAGE       |  P=0.200N                                          |  P=0.553                                           |
|FISHER EXACT           |               P=0.359      P=0.660N     P=0.309N   |               P=0.500      P=0.248        (e)      |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE   3
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    1/60 (2%)    2/60 (3%)  |  0/60 (0%)    0/60 (0%)    1/60 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         2.4%         5.0%      |   0.0%         0.0%         2.5%         2.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    0/37 (0%)    1/41 (2%)    1/37 (3%)  |  0/34 (0%)    0/40 (0%)    1/40 (3%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          729 (T)      660       |   ---          ---          736 (T)      638       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.070        (e)        P=0.510      P=0.234    |  P=0.219        (e)        P=0.532      P=0.504    |
|INCIDENTAL TUMOR       |  P=0.090        (e)        P=0.510      P=0.277    |  P=0.240        (e)        P=0.532      P=0.581    |
|LOGISTIC REGRESSION    |  P=0.070        (e)        P=0.510      P=0.234    |  P=0.208        (e)        P=0.532      P=0.497    |
|COCHRAN-ARMITAGE       |  P=0.071                                           |  P=0.207                                           |
|FISHER EXACT           |                 (e)        P=0.500      P=0.248    |                 (e)        P=0.500      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    5/60 (8%)    4/60 (7%)    3/60 (5%)  |  0/60 (0%)    1/60 (2%)    3/60 (5%)    1/60 (2%)  |
|ADJUSTED (b)           |   7.1%        12.4%         8.9%         7.6%      |   0.0%         2.5%         7.3%         2.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  2/39 (5%)    3/37 (8%)    2/41 (5%)    2/37 (5%)  |  0/34 (0%)    1/40 (3%)    2/40 (5%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |   592          540          553          660       |   ---          736 (T)      726          638       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.540N     P=0.329      P=0.514      P=0.636    |  P=0.286      P=0.532      P=0.155      P=0.504    |
|INCIDENTAL TUMOR       |  P=0.446N     P=0.444      P=0.465      P=0.625    |  P=0.243      P=0.532      P=0.089      P=0.581    |
|LOGISTIC REGRESSION    |  P=0.556      P=0.335      P=0.501      P=0.656    |  P=0.260      P=0.532      P=0.132      P=0.497    |
|COCHRAN-ARMITAGE       |  P=0.524N                                          |  P=0.255                                           |
|FISHER EXACT           |               P=0.359      P=0.500      P=0.660N   |               P=0.500      P=0.122      P=0.500    |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE   4
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    2/60 (3%)    2/60 (3%)    0/60 (0%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   2.6%         5.4%         4.9%         0.0%      |   2.6%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  1/39 (3%)    2/37 (5%)    2/41 (5%)    0/37 (0%)  |  0/34 (0%)    0/40 (0%)    0/40 (0%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      729 (T)      729 (T)      ---       |   714          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.359N     P=0.482      P=0.518      P=0.510N   |  P=0.186N     P=0.485N     P=0.475N     P=0.480N   |
|INCIDENTAL TUMOR       |  P=0.359N     P=0.482      P=0.517      P=0.510N   |  P=0.322N     P=0.674N     P=0.674N     P=0.674N   |
|LOGISTIC REGRESSION    |  P=0.359N     P=0.482      P=0.517      P=0.510N   |  P=0.197N     P=0.498N     P=0.498N     P=0.496N   |
|COCHRAN-ARMITAGE       |  P=0.351N                                          |  P=0.199N                                          |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.500N   |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    4/60 (7%)    2/60 (3%)    1/60 (2%)  |  2/60 (3%)    1/59 (2%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   6.8%        10.5%         4.9%         2.7%      |   5.9%         2.5%         0.0%         2.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/9 (0%)     0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  1/39 (3%)    3/37 (8%)    2/41 (5%)    1/37 (3%)  |  2/34 (6%)    1/40 (3%)    0/40 (0%)    1/40 (3%)  |
|FIRST INCIDENCE (DAYS) |   592          710          729 (T)      729 (T)   |   736 (T)      736 (T)      ---          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.191N     P=0.470      P=0.492N     P=0.334N   |  P=0.241N     P=0.443N     P=0.203N     P=0.443N   |
|INCIDENTAL TUMOR       |  P=0.177N     P=0.425      P=0.529N     P=0.339N   |  P=0.241N     P=0.443N     P=0.203N     P=0.443N   |
|LOGISTIC REGRESSION    |  P=0.184N     P=0.471      P=0.500N     P=0.309N   |  P=0.241N     P=0.443N     P=0.203N     P=0.443N   |
|COCHRAN-ARMITAGE       |  P=0.180N                                          |  P=0.280N                                          |
|FISHER EXACT           |               P=0.500      P=0.500N     P=0.309N   |               P=0.506N     P=0.248N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE   5
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatoblastoma                                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    2/60 (3%)    0/60 (0%)  |  0/60 (0%)    0/59 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         2.7%         4.8%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/9 (0%)     0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    1/37 (3%)    1/41 (2%)    0/37 (0%)  |  0/34 (0%)    0/40 (0%)    0/40 (0%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          729 (T)      669          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.547      P=0.490      P=0.243        (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.585      P=0.490      P=0.213        (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.550      P=0.490      P=0.238        (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.553                                           |    (e)                                             |
|FISHER EXACT           |               P=0.500      P=0.248        (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 28/60 (47%)  32/60 (53%)  26/60 (43%)  28/60 (47%) | 32/60 (53%)  24/59 (41%)  22/60 (37%)  19/60 (32%) |
|ADJUSTED (b)           |  59.9%        73.9%        54.6%        64.3%      |  70.6%        55.3%        49.7%        44.6%      |
|INTERIM SACRIFICE 1 (c)|  4/10 (40%)   2/10 (20%)   1/10 (10%)   2/10 (20%) |  2/10 (20%)   2/9 (22%)    1/9 (11%)    1/10 (10%) |
|TERMINAL (d)           | 21/39 (54%)  26/37 (70%)  20/41 (49%)  22/37 (59%) | 21/34 (62%)  21/40 (53%)  18/40 (45%)  17/40 (43%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      357          385          456 (I)   |   455 (I)      455 (I)      455 (I)      455 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.484N     P=0.208      P=0.363N     P=0.481    |  P=0.001N**   P=0.031N*    P=0.015N*    P=0.003N** |
|INCIDENTAL TUMOR       |  P=0.424N     P=0.202      P=0.335N     P=0.515N   |  P=0.005N**   P=0.096N     P=0.077N     P=0.009N** |
|LOGISTIC REGRESSION    |  P=0.433N     P=0.203      P=0.421N     P=0.556    |  P=0.005N**   P=0.090N     P=0.041N*    P=0.008N** |
|COCHRAN-ARMITAGE       |  P=0.433N                                          |  P=0.009N**                                        |
|FISHER EXACT           |               P=0.292      P=0.427N     P=0.573N   |               P=0.115N     P=0.049N*    P=0.013N*  |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE   6
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 10/60 (17%)   9/60 (15%)   5/60 (8%)   14/60 (23%) | 13/60 (22%)   8/59 (14%)   6/60 (10%)  13/60 (22%) |
|ADJUSTED (b)           |  21.7%        21.0%        11.4%        30.6%      |  31.3%        17.5%        13.6%        29.3%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   2/10 (20%)   0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/9 (0%)     0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  6/39 (15%)   6/37 (16%)   3/41 (7%)    7/37 (19%) |  7/34 (21%)   5/40 (13%)   4/40 (10%)   9/40 (23%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      456 (I)      618          456 (I)   |   567          448          446          603       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.241      P=0.545N     P=0.132N     P=0.224    |  P=0.391N     P=0.124N     P=0.044N*    P=0.459N   |
|INCIDENTAL TUMOR       |  P=0.224      P=0.559N     P=0.148N     P=0.194    |  P=0.480      P=0.204N     P=0.124N     P=0.444    |
|LOGISTIC REGRESSION    |  P=0.267      P=0.505N     P=0.134N     P=0.251    |  P=0.525N     P=0.193N     P=0.126N     P=0.550    |
|COCHRAN-ARMITAGE       |  P=0.253                                           |  P=0.491N                                          |
|FISHER EXACT           |               P=0.500N     P=0.135N     P=0.247    |               P=0.179N     P=0.066N     P=0.588N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 10/60 (17%)  10/60 (17%)   7/60 (12%)  14/60 (23%) | 13/60 (22%)   8/59 (14%)   6/60 (10%)  13/60 (22%) |
|ADJUSTED (b)           |  21.7%        23.6%        15.8%        30.6%      |  31.3%        17.5%        13.6%        29.3%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   2/10 (20%)   0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/9 (0%)     0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  6/39 (15%)   7/37 (19%)   4/41 (10%)   7/37 (19%) |  7/34 (21%)   5/40 (13%)   4/40 (10%)   9/40 (23%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      456 (I)      618          456 (I)   |   567          448          446          603       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.232      P=0.549      P=0.290N     P=0.224    |  P=0.391N     P=0.124N     P=0.044N*    P=0.459N   |
|INCIDENTAL TUMOR       |  P=0.223      P=0.538      P=0.330N     P=0.194    |  P=0.480      P=0.204N     P=0.124N     P=0.444    |
|LOGISTIC REGRESSION    |  P=0.253      P=0.588      P=0.299N     P=0.251    |  P=0.525N     P=0.193N     P=0.126N     P=0.550    |
|COCHRAN-ARMITAGE       |  P=0.243                                           |  P=0.491N                                          |
|FISHER EXACT           |               P=0.596N     P=0.301N     P=0.247    |               P=0.179N     P=0.066N     P=0.588N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE   7
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 32/60 (53%)  37/60 (62%)  29/60 (48%)  39/60 (65%) | 35/60 (58%)  29/59 (49%)  28/60 (47%)  26/60 (43%) |
|ADJUSTED (b)           |  65.7%        79.9%        61.1%        80.9%      |  75.6%        62.3%        60.5%        57.4%      |
|INTERIM SACRIFICE 1 (c)|  5/10 (50%)   4/10 (40%)   1/10 (10%)   2/10 (20%) |  2/10 (20%)   2/9 (22%)    1/9 (11%)    1/10 (10%) |
|TERMINAL (d)           | 23/39 (59%)  28/37 (76%)  23/41 (56%)  28/37 (76%) | 23/34 (68%)  23/40 (58%)  22/40 (55%)  21/40 (53%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      357          385          456 (I)   |   455 (I)      448          446          455 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.165      P=0.156      P=0.296N     P=0.098    |  P=0.015N*    P=0.069N     P=0.045N*    P=0.022N*  |
|INCIDENTAL TUMOR       |  P=0.173      P=0.140      P=0.268N     P=0.140    |  P=0.054N     P=0.179N     P=0.201N     P=0.081N   |
|LOGISTIC REGRESSION    |  P=0.188      P=0.162      P=0.348N     P=0.120    |  P=0.042N*    P=0.179N     P=0.126N     P=0.049N*  |
|COCHRAN-ARMITAGE       |  P=0.192                                           |  P=0.055N                                          |
|FISHER EXACT           |               P=0.230      P=0.358N     P=0.133    |               P=0.206N     P=0.136N     P=0.072N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 32/60 (53%)  37/60 (62%)  31/60 (52%)  39/60 (65%) | 35/60 (58%)  29/59 (49%)  28/60 (47%)  26/60 (43%) |
|ADJUSTED (b)           |  65.7%        79.9%        64.2%        80.9%      |  75.6%        62.3%        60.5%        57.4%      |
|INTERIM SACRIFICE 1 (c)|  5/10 (50%)   4/10 (40%)   1/10 (10%)   2/10 (20%) |  2/10 (20%)   2/9 (22%)    1/9 (11%)    1/10 (10%) |
|TERMINAL (d)           | 23/39 (59%)  28/37 (76%)  24/41 (59%)  28/37 (76%) | 23/34 (68%)  23/40 (58%)  22/40 (55%)  21/40 (53%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      357          385          456 (I)   |   455 (I)      448          446          455 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.148      P=0.156      P=0.425N     P=0.098    |  P=0.015N*    P=0.069N     P=0.045N*    P=0.022N*  |
|INCIDENTAL TUMOR       |  P=0.158      P=0.140      P=0.412N     P=0.140    |  P=0.054N     P=0.179N     P=0.201N     P=0.081N   |
|LOGISTIC REGRESSION    |  P=0.166      P=0.162      P=0.493N     P=0.120    |  P=0.042N*    P=0.179N     P=0.126N     P=0.049N*  |
|COCHRAN-ARMITAGE       |  P=0.170                                           |  P=0.055N                                          |
|FISHER EXACT           |               P=0.230      P=0.500N     P=0.133    |               P=0.206N     P=0.136N     P=0.072N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE   8
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 12/60 (20%)   8/60 (13%)  12/60 (20%)  13/60 (22%) |  1/60 (2%)    5/60 (8%)    6/60 (10%)   2/60 (3%)  |
|ADJUSTED (b)           |  28.8%        20.8%        27.2%        28.3%      |   2.9%        12.5%        13.9%         4.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   3/10 (30%) |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           | 10/39 (26%)   7/37 (19%)  10/41 (24%)   7/37 (19%) |  1/34 (3%)    5/40 (13%)   4/40 (10%)   1/40 (3%)  |
|FIRST INCIDENCE (DAYS) |   592          626          456 (I)      456 (I)   |   736 (T)      736 (T)      504          684       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.341      P=0.276N     P=0.548N     P=0.453    |  P=0.441      P=0.143      P=0.084      P=0.540    |
|INCIDENTAL TUMOR       |  P=0.357      P=0.283N     P=0.571N     P=0.526    |  P=0.367      P=0.143      P=0.073      P=0.441    |
|LOGISTIC REGRESSION    |  P=0.364      P=0.274N     P=0.590      P=0.496    |  P=0.385      P=0.143      P=0.059      P=0.508    |
|COCHRAN-ARMITAGE       |  P=0.366                                           |  P=0.376                                           |
|FISHER EXACT           |               P=0.232N     P=0.590N     P=0.500    |               P=0.103      P=0.057      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/60 (12%)   6/60 (10%)   8/60 (13%)   8/60 (13%) |  3/60 (5%)    2/60 (3%)    2/60 (3%)    3/60 (5%)  |
|ADJUSTED (b)           |  17.5%        14.6%        18.8%        21.6%      |   8.4%         5.0%         5.0%         6.9%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  6/39 (15%)   3/37 (8%)    7/41 (17%)   8/37 (22%) |  2/34 (6%)    2/40 (5%)    2/40 (5%)    2/40 (5%)  |
|FIRST INCIDENCE (DAYS) |   709          588          571          729 (T)   |   714          736 (T)      736 (T)      537       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.362      P=0.542N     P=0.536      P=0.457    |  P=0.508N     P=0.434N     P=0.430N     P=0.601N   |
|INCIDENTAL TUMOR       |  P=0.344      P=0.582N     P=0.510      P=0.481    |  P=0.553N     P=0.516N     P=0.516N     P=0.650    |
|LOGISTIC REGRESSION    |  P=0.372      P=0.545N     P=0.498      P=0.479    |  P=0.560N     P=0.482N     P=0.473N     P=0.657N   |
|COCHRAN-ARMITAGE       |  P=0.386                                           |  P=0.569                                           |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.500    |               P=0.500N     P=0.500N     P=0.660N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE   9
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 18/60 (30%)  13/60 (22%)  17/60 (28%)  20/60 (33%) |  4/60 (7%)    7/60 (12%)   8/60 (13%)   5/60 (8%)  |
|ADJUSTED (b)           |  42.6%        32.2%        39.0%        45.0%      |  11.2%        17.5%        18.7%        11.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   3/10 (30%) |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           | 15/39 (38%)  10/37 (27%)  15/41 (37%)  14/37 (38%) |  3/34 (9%)    7/40 (18%)   6/40 (15%)   3/40 (8%)  |
|FIRST INCIDENCE (DAYS) |   592          588          456 (I)      456 (I)   |   714          736 (T)      504          537       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.278      P=0.258N     P=0.441N     P=0.359    |  P=0.495      P=0.356      P=0.255      P=0.576    |
|INCIDENTAL TUMOR       |  P=0.297      P=0.280N     P=0.472N     P=0.434    |  P=0.406      P=0.302      P=0.196      P=0.453    |
|LOGISTIC REGRESSION    |  P=0.297      P=0.254N     P=0.506N     P=0.399    |  P=0.415      P=0.300      P=0.181      P=0.510    |
|COCHRAN-ARMITAGE       |  P=0.311                                           |  P=0.402                                           |
|FISHER EXACT           |               P=0.202N     P=0.500N     P=0.422    |               P=0.264      P=0.181      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  1/60 (2%)    1/59 (2%)    2/59 (3%)    0/59 (0%)  |
|ADJUSTED (b)           |                                                    |   2.9%         1.7%         5.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    1/10 (10%)   0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |                                                    |  1/34 (3%)    0/39 (0%)    2/40 (5%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   736 (T)      455 (I)      736 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.362N     P=0.745N     P=0.557      P=0.468N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.362N     P=0.745N     P=0.557      P=0.468N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.398N     P=0.759      P=0.557      P=0.468N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.398N                                          |
|FISHER EXACT           |                                                    |               P=0.748      P=0.494      P=0.504N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE  10
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/55 (0%)    0/53 (0%)    0/50 (0%)    0/56 (0%)  |  5/52 (10%)   4/57 (7%)    6/56 (11%)   4/54 (7%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  15.5%        10.5%        15.3%        11.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/8 (0%)     0/9 (0%)     0/9 (0%)     0/9 (0%)   |
|TERMINAL (d)           |  0/36 (0%)    0/32 (0%)    0/31 (0%)    0/35 (0%)  |  4/30 (13%)   4/38 (11%)   5/38 (13%)   4/35 (11%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   711          736 (T)      735          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.388N     P=0.369N     P=0.602N     P=0.411N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.454N     P=0.415N     P=0.526      P=0.460N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.418N     P=0.409N     P=0.619      P=0.452N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.457N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.442N     P=0.553      P=0.476N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/55 (0%)    0/53 (0%)    0/50 (0%)    0/56 (0%)  |  5/52 (10%)   5/57 (9%)    6/56 (11%)   4/54 (7%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  15.5%        12.7%        15.3%        11.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/8 (0%)     0/9 (0%)     0/9 (0%)     0/9 (0%)   |
|TERMINAL (d)           |  0/36 (0%)    0/32 (0%)    0/31 (0%)    0/35 (0%)  |  4/30 (13%)   4/38 (11%)   5/38 (13%)   4/35 (11%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   711          724          735          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.358N     P=0.496N     P=0.602N     P=0.411N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.455N     P=0.597N     P=0.526      P=0.460N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.396N     P=0.547N     P=0.619      P=0.452N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.428N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.569N     P=0.553      P=0.476N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE  11
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    2/60 (3%)  |  2/60 (3%)    2/60 (3%)    2/60 (3%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         4.8%      |   5.6%         4.7%         4.6%         2.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    0/37 (0%)    0/41 (0%)    1/37 (3%)  |  1/34 (3%)    1/40 (3%)    1/40 (3%)    1/40 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          581       |   721          659          504          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.056        (e)          (e)        P=0.227    |  P=0.337N     P=0.653N     P=0.651N     P=0.450N   |
|INCIDENTAL TUMOR       |  P=0.037 *      (e)          (e)        P=0.161    |  P=0.438N     P=0.572      P=0.684N     P=0.559N   |
|LOGISTIC REGRESSION    |  P=0.057        (e)          (e)        P=0.238    |  P=0.371N     P=0.692N     P=0.693      P=0.484N   |
|COCHRAN-ARMITAGE       |  P=0.057                                           |  P=0.373N                                          |
|FISHER EXACT           |                 (e)          (e)        P=0.248    |               P=0.691N     P=0.691N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/58 (3%)    2/59 (3%)    0/59 (0%)    1/60 (2%)  |  1/60 (2%)    1/60 (2%)    2/60 (3%)    0/60 (0%)  |
|ADJUSTED (b)           |   4.5%         5.2%         0.0%         2.5%      |   2.9%         2.5%         4.7%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/38 (0%)    1/37 (3%)    0/41 (0%)    0/37 (0%)  |  0/34 (0%)    1/40 (3%)    1/40 (3%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |   612          710          ---          691       |   729          736 (T)      709          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.265N     P=0.677      P=0.247N     P=0.522N   |  P=0.360N     P=0.727N     P=0.545      P=0.473N   |
|INCIDENTAL TUMOR       |  P=0.224N     P=0.604      P=0.337N     P=0.483N   |  P=0.514N     P=0.690      P=0.321      P=0.674N   |
|LOGISTIC REGRESSION    |  P=0.274N     P=0.684      P=0.233N     P=0.489N   |  P=0.383N     P=0.753N     P=0.509      P=0.492N   |
|COCHRAN-ARMITAGE       |  P=0.247N                                          |  P=0.393N                                          |
|FISHER EXACT           |               P=0.684N     P=0.244N     P=0.487N   |               P=0.752N     P=0.500      P=0.500N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE  12
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/60 (2%)    0/60 (0%)    1/60 (2%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   4.9%         2.7%         0.0%         2.3%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  1/39 (3%)    1/37 (3%)    0/41 (0%)    0/37 (0%)  |  0/34 (0%)    0/40 (0%)    0/40 (0%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |   701          729 (T)      ---          660       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.287N     P=0.515N     P=0.234N     P=0.512N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.236N     P=0.545N     P=0.265N     P=0.410N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.284N     P=0.521N     P=0.238N     P=0.506N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.281N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.500N     P=0.248N     P=0.500N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/60 (2%)    1/60 (2%)    1/60 (2%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   4.9%         2.7%         2.4%         2.3%      |   2.9%         0.0%         0.0%         2.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  1/39 (3%)    1/37 (3%)    1/41 (2%)    0/37 (0%)  |  1/34 (3%)    0/40 (0%)    0/40 (0%)    1/40 (3%)  |
|FIRST INCIDENCE (DAYS) |   701          729 (T)      729 (T)      660       |   736 (T)      ---          ---          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.358N     P=0.515N     P=0.488N     P=0.512N   |  P=0.622N     P=0.468N     P=0.468N     P=0.725N   |
|INCIDENTAL TUMOR       |  P=0.305N     P=0.545N     P=0.522N     P=0.410N   |  P=0.622N     P=0.468N     P=0.468N     P=0.725N   |
|LOGISTIC REGRESSION    |  P=0.356N     P=0.521N     P=0.500N     P=0.506N   |  P=0.622N     P=0.468N     P=0.468N     P=0.725N   |
|COCHRAN-ARMITAGE       |  P=0.351N                                          |  P=0.648                                           |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500N   |               P=0.500N     P=0.500N     P=0.752N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE  13
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/59 (2%)    1/60 (2%)    1/60 (2%)    3/60 (5%)  |                                                    |
|ADJUSTED (b)           |   2.6%         2.4%         2.4%         7.8%      |                                                    |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |                                                    |
|TERMINAL (d)           |  1/39 (3%)    0/37 (0%)    1/41 (2%)    2/37 (5%)  |                                                    |
|FIRST INCIDENCE (DAYS) |   729 (T)      640          729 (T)      722       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.176      P=0.749      P=0.751N     P=0.293    |                                                    |
|INCIDENTAL TUMOR       |  P=0.182      P=0.734      P=0.751N     P=0.351    |                                                    |
|LOGISTIC REGRESSION    |  P=0.179      P=0.758      P=0.751N     P=0.297    |                                                    |
|COCHRAN-ARMITAGE       |  P=0.182                                           |                                                    |
|FISHER EXACT           |               P=0.748N     P=0.748N     P=0.316    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/59 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  2/59 (3%)    0/60 (0%)    0/59 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   5.9%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/38 (0%)    0/37 (0%)    0/41 (0%)    0/37 (0%)  |  2/34 (6%)    0/40 (0%)    0/40 (0%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   736 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.046N*    P=0.203N     P=0.203N     P=0.203N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.046N*    P=0.203N     P=0.203N     P=0.203N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.046N*    P=0.203N     P=0.203N     P=0.203N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.056N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.244N     P=0.248N     P=0.244N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE  14
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/59 (2%)    0/60 (0%)    2/60 (3%)    1/60 (2%)  |  0/59 (0%)    1/60 (2%)    2/59 (3%)    3/60 (5%)  |
|ADJUSTED (b)           |   1.7%         0.0%         4.9%         2.7%      |   0.0%         2.5%         4.9%         7.5%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/38 (0%)    0/37 (0%)    2/41 (5%)    1/37 (3%)  |  0/34 (0%)    1/40 (3%)    1/40 (3%)    3/40 (8%)  |
|FIRST INCIDENCE (DAYS) |   456 (I)      ---          729 (T)      729 (T)   |   ---          736 (T)      735          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.484      P=0.500N     P=0.518      P=0.757    |  P=0.065      P=0.532      P=0.279      P=0.151    |
|INCIDENTAL TUMOR       |  P=0.484      P=0.500N     P=0.518      P=0.757    |  P=0.050 *    P=0.532      P=0.171      P=0.151    |
|LOGISTIC REGRESSION    |  P=0.490      P=0.470N     P=0.501      P=0.757    |  P=0.062      P=0.532      P=0.272      P=0.151    |
|COCHRAN-ARMITAGE       |  P=0.489                                           |  P=0.054                                           |
|FISHER EXACT           |               P=0.496N     P=0.506      P=0.748N   |               P=0.504      P=0.248      P=0.125    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/59 (3%)    0/60 (0%)    2/60 (3%)    1/60 (2%)  |  0/59 (0%)    1/60 (2%)    2/59 (3%)    3/60 (5%)  |
|ADJUSTED (b)           |   4.3%         0.0%         4.9%         2.7%      |   0.0%         2.5%         4.9%         7.5%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  1/38 (3%)    0/37 (0%)    2/41 (5%)    1/37 (3%)  |  0/34 (0%)    1/40 (3%)    1/40 (3%)    3/40 (8%)  |
|FIRST INCIDENCE (DAYS) |   456 (I)      ---          729 (T)      729 (T)   |   ---          736 (T)      735          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.459N     P=0.243N     P=0.673N     P=0.506N   |  P=0.065      P=0.532      P=0.279      P=0.151    |
|INCIDENTAL TUMOR       |  P=0.459N     P=0.243N     P=0.673N     P=0.506N   |  P=0.050 *    P=0.532      P=0.171      P=0.151    |
|LOGISTIC REGRESSION    |  P=0.452N     P=0.223N     P=0.688N     P=0.496N   |  P=0.062      P=0.532      P=0.272      P=0.151    |
|COCHRAN-ARMITAGE       |  P=0.453N                                          |  P=0.054                                           |
|FISHER EXACT           |               P=0.244N     P=0.684N     P=0.494N   |               P=0.504      P=0.248      P=0.125    |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE  15
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/60 (0%)    3/60 (5%)    1/60 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |                                                    |   0.0%         6.6%         2.5%         2.5%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    1/10 (10%)   0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |                                                    |  0/34 (0%)    2/40 (5%)    1/40 (3%)    1/40 (3%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          455 (I)      736 (T)      736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.496      P=0.143      P=0.532      P=0.532    |
|INCIDENTAL TUMOR       |                                                    |  P=0.496      P=0.143      P=0.532      P=0.532    |
|LOGISTIC REGRESSION    |                                                    |  P=0.460      P=0.121      P=0.532      P=0.532    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.459                                           |
|FISHER EXACT           |                                                    |               P=0.122      P=0.500      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    0/60 (0%)    2/60 (3%)    1/60 (2%)  |  0/60 (0%)    3/60 (5%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   5.1%         0.0%         4.9%         2.7%      |   0.0%         7.2%         2.5%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  2/39 (5%)    0/37 (0%)    2/41 (5%)    1/37 (3%)  |  0/34 (0%)    2/40 (5%)    1/40 (3%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      ---          729 (T)      729 (T)   |   ---          684          736 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.467N     P=0.250N     P=0.677N     P=0.518N   |  P=0.450N     P=0.144      P=0.532        (e)      |
|INCIDENTAL TUMOR       |  P=0.467N     P=0.250N     P=0.677N     P=0.518N   |  P=0.524N     P=0.089      P=0.532        (e)      |
|LOGISTIC REGRESSION    |  P=0.467N     P=0.250N     P=0.677N     P=0.518N   |  P=0.477N     P=0.122      P=0.532        (e)      |
|COCHRAN-ARMITAGE       |  P=0.459N                                          |  P=0.485N                                          |
|FISHER EXACT           |               P=0.248N     P=0.691N     P=0.500N   |               P=0.122      P=0.500        (e)      |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE  16
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/60 (7%)    7/60 (12%)   2/60 (3%)    3/60 (5%)  |  4/60 (7%)    3/60 (5%)    3/60 (5%)    2/60 (3%)  |
|ADJUSTED (b)           |   8.8%        17.6%         4.9%         7.8%      |  10.1%         7.2%         7.2%         4.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  1/39 (3%)    5/37 (14%)   2/41 (5%)    2/37 (5%)  |  2/34 (6%)    2/40 (5%)    2/40 (5%)    1/40 (3%)  |
|FIRST INCIDENCE (DAYS) |   592          560          729 (T)      691       |   388          684          709          684       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.289N     P=0.237      P=0.337N     P=0.534N   |  P=0.214N     P=0.439N     P=0.435N     P=0.293N   |
|INCIDENTAL TUMOR       |  P=0.289N     P=0.190      P=0.377N     P=0.555N   |  P=0.357N     P=0.578N     P=0.526N     P=0.429N   |
|LOGISTIC REGRESSION    |  P=0.272N     P=0.180      P=0.336N     P=0.504N   |  P=0.251N     P=0.500N     P=0.503N     P=0.338N   |
|COCHRAN-ARMITAGE       |  P=0.269N                                          |  P=0.255N                                          |
|FISHER EXACT           |               P=0.264      P=0.340N     P=0.500N   |               P=0.500N     P=0.500N     P=0.340N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/60 (10%)   7/60 (12%)   4/60 (7%)    4/60 (7%)  |  4/60 (7%)    5/60 (8%)    4/60 (7%)    2/60 (3%)  |
|ADJUSTED (b)           |  13.6%        17.6%         9.8%        10.4%      |  10.1%        12.0%         9.6%         4.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  3/39 (8%)    5/37 (14%)   4/41 (10%)   3/37 (8%)  |  2/34 (6%)    4/40 (10%)   3/40 (8%)    1/40 (3%)  |
|FIRST INCIDENCE (DAYS) |   592          560          729 (T)      691       |   388          684          709          684       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.256N     P=0.456      P=0.358N     P=0.411N   |  P=0.200N     P=0.577      P=0.570N     P=0.293N   |
|INCIDENTAL TUMOR       |  P=0.256N     P=0.409      P=0.390N     P=0.423N   |  P=0.324N     P=0.453      P=0.634      P=0.429N   |
|LOGISTIC REGRESSION    |  P=0.241N     P=0.398      P=0.370N     P=0.380N   |  P=0.244N     P=0.501      P=0.640      P=0.338N   |
|COCHRAN-ARMITAGE       |  P=0.236N                                          |  P=0.250N                                          |
|FISHER EXACT           |               P=0.500      P=0.372N     P=0.372N   |               P=0.500      P=0.641N     P=0.340N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE  17
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |  4/60 (7%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   2.3%         0.0%         0.0%         2.7%      |  10.7%         0.0%         0.0%         2.4%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  0/39 (0%)    0/37 (0%)    0/41 (0%)    1/37 (3%)  |  3/34 (9%)    0/40 (0%)    0/40 (0%)    0/40 (0%)  |
|FIRST INCIDENCE (DAYS) |   639          ---          ---          729 (T)   |   502          ---          ---          718       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.645      P=0.514N     P=0.500N     P=0.752    |  P=0.041N*    P=0.051N     P=0.051N     P=0.147N   |
|INCIDENTAL TUMOR       |  P=0.589      P=0.536N     P=0.536N     P=0.679    |  P=0.056N     P=0.050N     P=0.033N*    P=0.200N   |
|LOGISTIC REGRESSION    |  P=0.648      P=0.498N     P=0.502N     P=0.761    |  P=0.051N     P=0.063N     P=0.064N     P=0.178N   |
|COCHRAN-ARMITAGE       |  P=0.648                                           |  P=0.052N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.752N   |               P=0.059N     P=0.059N     P=0.182N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated                                               |
|     Cell Type                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    5/60 (8%)    2/60 (3%)    3/60 (5%)  | 10/60 (17%)   9/60 (15%)  13/60 (22%)   9/60 (15%) |
|ADJUSTED (b)           |   7.3%        12.4%         4.7%         7.7%      |  24.3%        22.5%        29.9%        21.2%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           |  2/39 (5%)    3/37 (8%)    1/41 (2%)    2/37 (5%)  |  5/34 (15%)   9/40 (23%)  10/40 (25%)   7/40 (18%) |
|FIRST INCIDENCE (DAYS) |   679          616          661          686       |   665          736 (T)      490          642       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.469N     P=0.330      P=0.489N     P=0.639    |  P=0.405N     P=0.391N     P=0.450      P=0.402N   |
|INCIDENTAL TUMOR       |  P=0.456N     P=0.297      P=0.539N     P=0.618N   |  P=0.475      P=0.596N     P=0.206      P=0.573    |
|LOGISTIC REGRESSION    |  P=0.496N     P=0.329      P=0.501N     P=0.650    |  P=0.504N     P=0.486N     P=0.190      P=0.479N   |
|COCHRAN-ARMITAGE       |  P=0.456N                                          |  P=0.526N                                          |
|FISHER EXACT           |               P=0.359      P=0.500N     P=0.660N   |               P=0.500N     P=0.322      P=0.500N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE  18
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 40/60 (67%)  35/60 (58%)  37/60 (62%)  39/60 (65%) | 36/60 (60%)  34/60 (57%)  30/60 (50%)  25/60 (42%) |
|ADJUSTED (b)           |  81.1%        77.3%        75.1%        80.7%      |  79.6%        71.7%        63.4%        56.3%      |
|INTERIM SACRIFICE 1 (c)|  5/10 (50%)   2/10 (20%)   2/10 (20%)   5/10 (50%) |  2/10 (20%)   4/10 (40%)   1/9 (11%)    1/10 (10%) |
|TERMINAL (d)           | 30/39 (77%)  27/37 (73%)  29/41 (71%)  28/37 (76%) | 25/34 (74%)  27/40 (68%)  23/40 (58%)  21/40 (53%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      357          385          456 (I)   |   455 (I)      455 (I)      394          455 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.499      P=0.346N     P=0.271N     P=0.520    |  P=0.003N**   P=0.165N     P=0.057N     P=0.007N** |
|INCIDENTAL TUMOR       |  P=0.460N     P=0.272N     P=0.242N     P=0.489N   |  P=0.012N*    P=0.382N     P=0.202N     P=0.017N*  |
|LOGISTIC REGRESSION    |  P=0.481N     P=0.318N     P=0.337N     P=0.514N   |  P=0.013N*    P=0.419N     P=0.173N     P=0.020N*  |
|COCHRAN-ARMITAGE       |  P=0.488N                                          |  P=0.020N*                                         |
|FISHER EXACT           |               P=0.225N     P=0.352N     P=0.500N   |               P=0.427N     P=0.179N     P=0.034N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 24/60 (40%)  27/60 (45%)  20/60 (33%)  29/60 (48%) | 31/60 (52%)  22/60 (37%)  26/60 (43%)  28/60 (47%) |
|ADJUSTED (b)           |  48.5%        56.9%        42.5%        60.0%      |  63.1%        47.3%        55.0%        56.0%      |
|INTERIM SACRIFICE 1 (c)|  2/10 (20%)   3/10 (30%)   0/10 (0%)    1/10 (10%) |  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |
|TERMINAL (d)           | 14/39 (36%)  17/37 (46%)  14/41 (34%)  18/37 (49%) | 16/34 (47%)  16/40 (40%)  19/40 (48%)  18/40 (45%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      456 (I)      571          456 (I)   |   388          448          446          493       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.273      P=0.295      P=0.270N     P=0.203    |  P=0.220N     P=0.041N*    P=0.121N     P=0.213N   |
|INCIDENTAL TUMOR       |  P=0.273      P=0.186      P=0.334N     P=0.245    |  P=0.473      P=0.148N     P=0.365N     P=0.550    |
|LOGISTIC REGRESSION    |  P=0.285      P=0.222      P=0.294N     P=0.205    |  P=0.419N     P=0.074N     P=0.374N     P=0.384N   |
|COCHRAN-ARMITAGE       |  P=0.290                                           |  P=0.379N                                          |
|FISHER EXACT           |               P=0.356      P=0.285N     P=0.231    |               P=0.071N     P=0.232N     P=0.358N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 07                                                 PAGE  19
                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      3.6          6.0          10.0      |   0 MG/KG      3.6          6.0          10.0      |
|                       |                MG/KG        MG/KG        MG/KG     |                MG/KG        MG/KG        MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 48/60 (80%)  46/60 (77%)  45/60 (75%)  51/60 (85%) | 48/60 (80%)  44/60 (73%)  42/60 (70%)  40/60 (67%) |
|ADJUSTED (b)           |  88.8%        88.3%        86.4%        92.7%      |  94.1%        86.0%        82.2%        78.4%      |
|INTERIM SACRIFICE 1 (c)|  6/10 (60%)   5/10 (50%)   2/10 (20%)   5/10 (50%) |  2/10 (20%)   4/10 (40%)   1/9 (11%)    1/10 (10%) |
|TERMINAL (d)           | 33/39 (85%)  31/37 (84%)  34/41 (83%)  33/37 (89%) | 31/34 (91%)  33/40 (83%)  31/40 (78%)  29/40 (73%) |
|FIRST INCIDENCE (DAYS) |   456 (I)      357          385          456 (I)   |   388          448          394          455 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.276      P=0.550      P=0.272N     P=0.244    |  P=0.015N*    P=0.077N     P=0.043N*    P=0.024N*  |
|INCIDENTAL TUMOR       |  P=0.369      P=0.587      P=0.252N     P=0.458    |  P=0.044N*    P=0.258N     P=0.128N     P=0.072N   |
|LOGISTIC REGRESSION    |  P=0.315      P=0.556N     P=0.305N     P=0.311    |  P=0.034N*    P=0.237N     P=0.148N     P=0.039N*  |
|COCHRAN-ARMITAGE       |  P=0.300                                           |  P=0.054N                                          |
|FISHER EXACT           |               P=0.412N     P=0.331N     P=0.316    |               P=0.259N     P=0.146N     P=0.074N   |
|=================================================================================================================================|

 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   456
          Female interim sacrifices(days): 455
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.

  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).