TDMS Study 05069-07 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE
NTP Experiment-Test: 05069-07 Report: PEIRPT09
Study Type: CHRONIC Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
CORE STUDY
Facility: TSI Mason Research
Chemical CAS #: 147-47-7
Lock Date: 08/05/92
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 002 0 MG/KG
Include 004 3.6 MG/KG
Include 006 6.0 MG/KG
Include 008 10.0 MG/KG
Include 001 0 MG/KG
Include 003 3.6 MG/KG
Include 005 6.0 MG/KG
Include 007 10.0 MG/KG
Page 1
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 2| 3| 4| 4| 4| 4| 4| 0| 4| 4| 1| 4| 4| 0| 0| 4| 4| 4| 8| 1| 4| 4|
| 1| 1| 1| 9| 0| 1| 1| 1| 1| 1| 9| 1| 1| 4| 1| 1| 2| 8| 1| 1| 1| 4| 4| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 5| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + A + + + A A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A A + + + A + + +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | X X X X X |
Congestion | 2|
Eosinophilic Focus | X 3 X X X X X X X |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 1 |
Mixed Cell Focus | X X |
Necrosis | 2 2 1 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 3 2 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 |
Necrosis | |
Acinus, Atrophy | 4 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Acinus, Atrophy | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
Infiltration Cellular, Eosinophil | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 2| 3| 4| 4| 4| 4| 4| 0| 4| 4| 1| 4| 4| 0| 0| 4| 4| 4| 8| 1| 4| 4|
| 1| 1| 1| 9| 0| 1| 1| 1| 1| 1| 9| 1| 1| 4| 1| 1| 2| 8| 1| 1| 1| 4| 4| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 5| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Fibrosis | 1 |
Hyperplasia | 1 |
Capsule, Hyperplasia | 2 1 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 1 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | 2 1 2 1 1 1 2 1 1 1 2 2 1 1|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + M + + + + + M + M + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + M + + M + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 1 1 2 1 3 2 2 1 1 1 1 1 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
C-Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia | 1 3 1 2 2 2 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 2 |
Pigmentation | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Cyst | X X X X X X 3 3|
Hemorrhage | 4 3 |
Infiltration Cellular, Lymphocyte | |
Periovarian Tissue, Inflammation, | |
Chronic Active | 4 |
Periovarian Tissue, Necrosis | 2 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Angiectasis | 2 4 2 |
Dilatation | 3 3 3 |
Hemorrhage | |
Hyperplasia, Cystic | 2 3 3 2 3 2 3 4 3 3 2 2 2 3 3 1 1 2 2 3 3|
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 1 1 1 3 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 2| 3| 4| 4| 4| 4| 4| 0| 4| 4| 1| 4| 4| 0| 0| 4| 4| 4| 8| 1| 4| 4|
| 1| 1| 1| 9| 0| 1| 1| 1| 1| 1| 9| 1| 1| 4| 1| 1| 2| 8| 1| 1| 1| 4| 4| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 5| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
Angiectasis | 1 1 |
Ectasia | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 4 3 3 4 |
Hyperplasia, Lymphoid | 2 2 |
Lymphoid Follicle, Atrophy | 4 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Skin, Site of Application, Acanthosis| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Peripheral Nerve | + |
Demyelination | 2 |
__________________________________________________________________________|
Spinal Cord | + |
Demyelination | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 |
Infiltration Cellular, Histiocyte | 2 |
Bronchiole, Degeneration, Hyaline | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Inflammation, Acute | 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 2| 3| 4| 4| 4| 4| 4| 0| 4| 4| 1| 4| 4| 0| 0| 4| 4| 4| 8| 1| 4| 4|
| 1| 1| 1| 9| 0| 1| 1| 1| 1| 1| 9| 1| 1| 4| 1| 1| 2| 8| 1| 1| 1| 4| 4| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 5| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | |
Hyperplasia, Lymphoid | 2 2 |
Nephropathy, Chronic | 2 1 2 2 1 1 2 1 1 1 1 1 1 1 2 1 1|
Pigmentation | 1 2 |
Renal Tubule, Degeneration, Hyaline | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 3| 6| 7| 7| 7| |
DAY ON TEST | 4| 6| 4| 4| 4| 4| 7| 1| 4| 1| 4| 4| 4| 4| 4| 2| 4| 6| 4| 4| 8| 7| 4| 4| 4| |
| 1| 5| 1| 1| 1| 1| 5| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 8| 2| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + A + + + + + + + + + + A A + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + A + + + + + + + + + + A A + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + A + + + + + + + + + + + A + + +| 44 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + A + + + + + + + + + + A A + + +| 45 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Clear Cell Focus | X X X X | 9 |
Congestion | | 1 2.0|
Eosinophilic Focus | 3 X X X X X X X | 17 3.0|
Hyperplasia, Lymphoid | 1 | 1 1.0|
Inflammation, Chronic | | 1 1.0|
Mixed Cell Focus | X| 3 |
Necrosis | | 3 1.7|
Vacuolization Cytoplasmic | 2 | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
Fat, Necrosis | 3 3 | 6 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 3 1.3|
Necrosis | 1 | 1 1.0|
Acinus, Atrophy | 2 | 2 3.0|
Duct, Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2| 1 2.0|
Acinus, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 3 | 2 2.5|
Infiltration Cellular, Eosinophil | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 2 1.5|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 3| 6| 7| 7| 7| |
DAY ON TEST | 4| 6| 4| 4| 4| 4| 7| 1| 4| 1| 4| 4| 4| 4| 4| 2| 4| 6| 4| 4| 8| 7| 4| 4| 4| |
| 1| 5| 1| 1| 1| 1| 5| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 8| 2| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 1 1 1 1 1 1 | 6 1.0|
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Fibrosis | | 1 1.0|
Hyperplasia | | 1 1.0|
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 1 3 2 2 2 2 2 2 2 2 2 1 2 2 2 2| 48 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 2 2 2 1 1 1 2 2 1 1 1 3 1 1 | 30 1.4|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + M + + + + M + + + M + + + + M + + +| 40 |
Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + M + M +| 44 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Hyperplasia | 3 1 2 1 1 2 1 2 2| 22 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Cyst | 1 2 | 2 1.5|
C-Cell, Hyperplasia | | 1 1.0|
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 2 1 1 1 1 | 20 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Atrophy | 4 | 1 4.0|
Cyst | 2 2 4 2 2 3 | 14 2.6|
Hemorrhage | 2 | 3 3.0|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
Periovarian Tissue, Inflammation, | | |
Chronic Active | | 1 4.0|
Periovarian Tissue, Necrosis | | 3 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 3| 6| 7| 7| 7| |
DAY ON TEST | 4| 6| 4| 4| 4| 4| 7| 1| 4| 1| 4| 4| 4| 4| 4| 2| 4| 6| 4| 4| 8| 7| 4| 4| 4| |
| 1| 5| 1| 1| 1| 1| 5| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 8| 2| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Amyloid Deposition | | 1 3.0|
Angiectasis | | 3 2.7|
Dilatation | 4 4 3 | 6 3.3|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Cystic | 2 2 3 2 3 1 2 3 4 2 3 4 2 2 2 4 3 2 2 3 2| 42 2.5|
Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 1 1 1| 11 1.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 8 |
Iliac, Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + M + + + + + + + + + + + + +| 47 |
Angiectasis | | 2 1.0|
Ectasia | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 4 3 3 3 3 4 3 3 2 | 15 3.3|
Hyperplasia, Lymphoid | 2 2 | 4 2.0|
Lymphoid Follicle, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M M + + + + + + M + + + + + + + + +| 45 |
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 1 1.0|
Skin, Site of Application, Acanthosis| 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 3| 6| 7| 7| 7| |
DAY ON TEST | 4| 6| 4| 4| 4| 4| 7| 1| 4| 1| 4| 4| 4| 4| 4| 2| 4| 6| 4| 4| 8| 7| 4| 4| 4| |
| 1| 5| 1| 1| 1| 1| 5| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 8| 2| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 | 21 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Demyelination | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Demyelination | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 3 1.3|
Infiltration Cellular, Histiocyte | 2 | 2 2.0|
Bronchiole, Degeneration, Hyaline | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Inflammation, Acute | 1 1 1 1 1 1 1 1 | 17 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Hydronephrosis | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 2 2.0|
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 2 2 2 1 1 1 1| 33 1.2|
Pigmentation | | 2 1.5|
Renal Tubule, Degeneration, Hyaline | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 9| 9| 4| 4| 4| 4| 4| 4| 8| 4| 4| 5| 4| 4| 4| 4| 4| 4|
| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 4| 0| 0| 9| 0| 0| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3.6 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X X X X X X X X X |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia, Lymphoid | 1 |
Inflammation, Chronic | |
Mixed Cell Focus | X X |
Necrosis | 3 2 |
Vacuolization Cytoplasmic | 2 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | 3 3 3 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Acinus, Atrophy | 3 |
Duct, Cyst | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + M + + + + + + + + + + +|
Fibrosis | 2 |
Acinus, Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Hypertrophy | |
Capsule, Hyperplasia | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 9| 9| 4| 4| 4| 4| 4| 4| 8| 4| 4| 5| 4| 4| 4| 4| 4| 4|
| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 4| 0| 0| 9| 0| 0| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3.6 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 2 2 2 1 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + M + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + M + + + +|
Pars Distalis, Hyperplasia | 1 1 1 2 2 2 3 1 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Follicular Cell, Hyperplasia | 1 1 1 2 1 1 2 1 2 3 1 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 1 3 3 2 |
Hemorrhage | |
Periovarian Tissue, Necrosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 2 |
Hyperplasia, Cystic | 3 3 3 3 3 4 3 2 3 3 4 3 3 3 2 3 3 2 2 3 3 3 3 1|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 1 1 2 1 2 2 2 1 2 1 2 |
__________________________________________________________________________|
Lymph Node | + + |
Pancreatic, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 4 4 4 3|
Hyperplasia, Lymphoid | 3 3 2 2 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 9| 9| 4| 4| 4| 4| 4| 4| 8| 4| 4| 5| 4| 4| 4| 4| 4| 4|
| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 4| 0| 0| 9| 0| 0| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3.6 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Skin, Site of Application, Acanthosis| 1 |
Skin, Site of Application, | |
Hyperplasia, Mast Cell | 2 |
Subcutaneous Tissue, Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic | 2|
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + M + + + + + + + + + + + + + + + + +|
Exudate | 1 2 |
Foreign Body | X |
Inflammation, Acute | 1 |
Glands, Inflammation, Acute | 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Acute | |
Metaplasia, Osseous | 1 |
Nephropathy, Chronic | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2|
Pigmentation | |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 2| 4| 9| 4| 4| 4| 4| 4| 8| 4| 9| 4| 4| 4| 4| 4| 4| 6| 4| |
| 1| 8| 1| 1| 1| 0| 4| 0| 9| 0| 0| 0| 0| 0| 1| 1| 8| 1| 1| 1| 1| 1| 1| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
3.6 | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
MG/KG | 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X X X X | 7 |
Eosinophilic Focus | X X 4 X X X X X X | 20 4.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia, Lymphoid | 2 | 2 1.5|
Inflammation, Chronic | 1 | 1 1.0|
Mixed Cell Focus | | 2 |
Necrosis | | 2 2.5|
Vacuolization Cytoplasmic | 3 3 | 4 2.5|
Centrilobular, Necrosis | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + | 8 |
Fat, Inflammation, Chronic Active | 3 | 1 3.0|
Fat, Necrosis | 3 3 | 7 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
Acinus, Atrophy | 2 | 2 2.5|
Duct, Cyst | 4 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | | 1 2.0|
Acinus, Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 | 1 1.0|
Mineralization | 2 1 1 1 | 4 1.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 2| 4| 9| 4| 4| 4| 4| 4| 8| 4| 9| 4| 4| 4| 4| 4| 4| 6| 4| |
| 1| 8| 1| 1| 1| 0| 4| 0| 9| 0| 0| 0| 0| 0| 1| 1| 8| 1| 1| 1| 1| 1| 1| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
3.6 | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
MG/KG | 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hypertrophy | 1 | 1 1.0|
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2| 49 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 1 1 1 2 2 1 1 2 1 1 1 2 1 1 | 26 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + M + + + + + M + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia | 2 2 3 2 3 1 1 1 1 2 1 1 1| 23 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 1.0|
Follicular Cell, Hyperplasia | 1 1 1 1 2 1 1 1 1 2 1 1| 25 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Angiectasis | 3 2 | 2 2.5|
Cyst | 4 3 3 2 2 1 2 | 11 2.4|
Hemorrhage | 4 | 1 4.0|
Periovarian Tissue, Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 | 3 2.7|
Hyperplasia, Cystic | 3 3 3 3 3 2 3 3 3 3 3 3 3 3 2 1 3 3 3 1 3| 45 2.8|
Inflammation, Acute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 1 1 2 1 | 16 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Pancreatic, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 2| 4| 9| 4| 4| 4| 4| 4| 8| 4| 9| 4| 4| 4| 4| 4| 4| 6| 4| |
| 1| 8| 1| 1| 1| 0| 4| 0| 9| 0| 0| 0| 0| 0| 1| 1| 8| 1| 1| 1| 1| 1| 1| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
3.6 | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
MG/KG | 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Infiltration Cellular, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 3 3 3 | 11 3.3|
Hyperplasia, Lymphoid | 2 3 2 | 9 2.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + M + + + +| 46 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Skin, Site of Application, Acanthosis| | 1 1.0|
Skin, Site of Application, | | |
Hyperplasia, Mast Cell | | 1 2.0|
Subcutaneous Tissue, Angiectasis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 | 18 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1| 3 1.3|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Exudate | | 2 1.5|
Foreign Body | | 1 |
Inflammation, Acute | | 1 1.0|
Glands, Inflammation, Acute | 1 1 1 1 1 1 1 | 15 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 2| 4| 9| 4| 4| 4| 4| 4| 8| 4| 9| 4| 4| 4| 4| 4| 4| 6| 4| |
| 1| 8| 1| 1| 1| 0| 4| 0| 9| 0| 0| 0| 0| 0| 1| 1| 8| 1| 1| 1| 1| 1| 1| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
3.6 | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
MG/KG | 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 2 | 2 2.0|
Inflammation, Acute | 2 | 1 2.0|
Metaplasia, Osseous | | 1 1.0|
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1| 32 1.1|
Pigmentation | 2 | 1 2.0|
Renal Tubule, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 9| 4| 4| 2| 2| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 1| 4| 3| 3|
| 0| 0| 0| 0| 0| 0| 4| 0| 0| 8| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
6.0 | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0|
MG/KG | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + M + M +|
Hyperplasia, Lymphoid | 1 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Congestion | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X X X X X |
Hyperplasia, Lymphoid | 1 |
Inflammation, Chronic | 2 |
Mineralization | 2 |
Mixed Cell Focus | X |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Hyperplasia, Lymphoid | 3 |
Fat, Necrosis | 3 2 3 4 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 1 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Acute | |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 9| 4| 4| 2| 2| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 1| 4| 3| 3|
| 0| 0| 0| 0| 0| 0| 4| 0| 0| 8| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
6.0 | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0|
MG/KG | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 1 2 2 2 1 1 1 1 2 1 1 1|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 2 1 2 2 2 1 1 3 1 2 1 |
Rathke's Cleft, Hemorrhage | 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Fibrosis | 3 |
Follicular Cell, Hyperplasia | 2 2 1 2 1 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 2 1 2 3 |
Hemorrhage | 2 |
Periovarian Tissue, Necrosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Dilatation | 4 |
Hemorrhage | |
Hyperplasia, Cystic | 3 3 3 3 3 1 1 4 3 3 4 2 3 3 4 3 2 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 1 2 1 1 3 1 2 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 9| 4| 4| 2| 2| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 1| 4| 3| 3|
| 0| 0| 0| 0| 0| 0| 4| 0| 0| 8| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
6.0 | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0|
MG/KG | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | 1 |
Hematopoietic Cell Proliferation | 3 3 3 3 4 3 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + M + + +|
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1|
Subcutaneous Tissue, Congestion | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Subcutaneous Tissue, Skin, Site of | |
Application, Inflammation, | |
Chronic | 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 3 |
Infiltration Cellular, Lymphocyte | 1 |
Thalamus, Mineralization | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Peripheral Nerve | + |
Demyelination | 3 |
__________________________________________________________________________|
Spinal Cord | + |
Demyelination | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Hemorrhage | |
Glands, Inflammation, Acute | 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 9| 4| 4| 2| 2| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 1| 4| 3| 3|
| 0| 0| 0| 0| 0| 0| 4| 0| 0| 8| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
6.0 | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0|
MG/KG | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Nephropathy, Chronic | 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Necrosis | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6|
DAY ON TEST | 3| 3| 3| 4| 4| 2| 4| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 4| 9|
| 7| 7| 7| 0| 0| 8| 0| 6| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6| 6| 6| 6| 9| 6| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6.0 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
MG/KG | 2| 3| 4| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Congestion | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + M + + + + + + + + + + + + + + + + +|
Congestion | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X X X X X X X|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
Mineralization | |
Mixed Cell Focus | X |
__________________________________________________________________________|
Mesentery | + + + + |
Hyperplasia, Lymphoid | |
Fat, Necrosis | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1|
Acinus, Hyperplasia | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Acute | 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6|
DAY ON TEST | 3| 3| 3| 4| 4| 2| 4| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 4| 9|
| 7| 7| 7| 0| 0| 8| 0| 6| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6| 6| 6| 6| 9| 6| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6.0 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
MG/KG | 2| 3| 4| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + M + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 1 1 1 1 1 1 1 2 2 2 2 1|
__________________________________________________________________________|
Parathyroid Gland | + + + M + M M + + + + + + + M + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M M + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 1 3 1 1 1 3 |
Rathke's Cleft, Hemorrhage | |
__________________________________________________________________________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis | |
Follicular Cell, Hyperplasia | 1 1 1 1 1 2 1 1 3 3 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Pigmentation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + M +|
Angiectasis | 2|
Cyst | 2 1 3 2 3 |
Hemorrhage | 2|
Periovarian Tissue, Necrosis | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Dilatation | |
Hemorrhage | 3 |
Hyperplasia, Cystic | 4 4 3 2 3 4 2 3 3 4 3 4 2 4 3 3 4 1 3 4 2 4 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 1 2 1 2 2 3 |
__________________________________________________________________________|
Lymph Node | + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6|
DAY ON TEST | 3| 3| 3| 4| 4| 2| 4| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 4| 9|
| 7| 7| 7| 0| 0| 8| 0| 6| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6| 6| 6| 6| 9| 6| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6.0 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
MG/KG | 2| 3| 4| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | |
Hematopoietic Cell Proliferation | 2 2 3 3 3 3 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Subcutaneous Tissue, Congestion | |
Subcutaneous Tissue, Inflammation, | |
Chronic | 1 |
Subcutaneous Tissue, Skin, Site of | |
Application, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Infiltration Cellular, Lymphocyte | |
Thalamus, Mineralization | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Peripheral Nerve | + |
Demyelination | 1 |
__________________________________________________________________________|
Spinal Cord | + |
Demyelination | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 4 |
Infiltration Cellular, Histiocyte | 2 2 |
Serosa, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2 |
Hemorrhage | 3 |
Glands, Inflammation, Acute | 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6|
DAY ON TEST | 3| 3| 3| 4| 4| 2| 4| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 4| 9|
| 7| 7| 7| 0| 0| 8| 0| 6| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6| 6| 6| 6| 9| 6| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6.0 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
MG/KG | 2| 3| 4| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
6.0 | 3| | L |
MG/KG | 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 51 |
__________________________________________________________________________|____________|
Gallbladder | + | 48 |
Hyperplasia, Lymphoid | | 1 1.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 51 |
Congestion | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 50 |
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 51 |
Amyloid Deposition | | 1 2.0|
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 49 |
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + | 51 |
Angiectasis | | 3 1.7|
Clear Cell Focus | X | 5 |
Eosinophilic Focus | | 19 |
Hyperplasia, Lymphoid | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
Mineralization | | 1 2.0|
Mixed Cell Focus | | 2 |
__________________________________________________________________________|____________|
Mesentery | | 11 |
Hyperplasia, Lymphoid | | 1 3.0|
Fat, Necrosis | | 9 2.9|
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Acinus, Atrophy | | 3 1.3|
Acinus, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
Acinus, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Hyperplasia, Squamous | 1 | 4 1.5|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Erosion | | 1 2.0|
Inflammation, Acute | | 1 1.0|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
6.0 | 3| | L |
MG/KG | 4| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + | 51 |
Cardiomyopathy | | 11 1.1|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Capsule, Hyperplasia | | 50 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + | 49 |
Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
Hyperplasia | 2 | 32 1.4|
__________________________________________________________________________|____________|
Parathyroid Gland | + | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 47 |
Pars Distalis, Angiectasis | 1 | 2 1.5|
Pars Distalis, Hyperplasia | | 17 1.6|
Rathke's Cleft, Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + | 50 |
Cyst | 1 | 2 2.0|
Fibrosis | | 1 3.0|
Follicular Cell, Hyperplasia | | 25 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 50 |
Pigmentation | | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + | 50 |
Angiectasis | | 1 2.0|
Cyst | | 10 2.1|
Hemorrhage | | 2 2.0|
Periovarian Tissue, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + | 51 |
Angiectasis | | 2 2.0|
Dilatation | | 1 4.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Cystic | | 44 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
6.0 | 3| | L |
MG/KG | 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Myelofibrosis | | 15 1.6|
__________________________________________________________________________|____________|
Lymph Node | + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 51 |
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 51 |
Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + | 51 |
Angiectasis | | 1 1.0|
Hematopoietic Cell Proliferation | | 13 2.9|
Hyperplasia, Lymphoid | | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + | 48 |
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 50 |
__________________________________________________________________________|____________|
Skin | + | 51 |
Acanthosis | | 1 1.0|
Subcutaneous Tissue, Congestion | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 1.0|
Subcutaneous Tissue, Skin, Site of | | |
Application, Inflammation, | | |
Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
Hydrocephalus | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Thalamus, Mineralization | | 14 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
Demyelination | | 2 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
6.0 | 3| | L |
MG/KG | 4| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Demyelination | | 2 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Hemorrhage | | 2 3.0|
Infiltration Cellular, Histiocyte | | 3 2.0|
Serosa, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + | 51 |
Exudate | | 1 2.0|
Hemorrhage | | 1 3.0|
Glands, Inflammation, Acute | | 20 1.0|
__________________________________________________________________________|____________|
Trachea | + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Cyst | | 1 1.0|
Nephropathy, Chronic | | 37 1.1|
Renal Tubule, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 51 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|
| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10.0 | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG | 7| 8| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 9| 0| 1| 2| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Perforation | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Clear Cell Focus | X X X |
Eosinophilic Focus | X X 2 X 3 X X X X X X X |
Hematopoietic Cell Proliferation | 1 |
Mixed Cell Focus | X X X |
Necrosis | |
Thrombosis | |
Vacuolization Cytoplasmic | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + +|
Fat, Necrosis | 3 4 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | 1 |
Mineralization | 1 1 |
Ulcer | |
Glands, Cyst | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|
| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10.0 | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG | 7| 8| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 9| 0| 1| 2| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
Capsule, Hyperplasia | 3 2 3 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 1 1 1 2 1 2 1 1 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + M M M + + + + + + + + + +|
Cyst | 1 |
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + M + + M|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Hyperplasia | 3 1 2 1 3 1 3 2 1 2 1 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | |
Follicle, Hypertrophy | 3 |
Follicular Cell, Hyperplasia | 2 1 1 1 1 1 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Pigmentation | |
Arteriole, Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 3 2 1 2 1 3 1 3 2 |
Hemorrhage | 3 |
Inflammation, Granulomatous | |
Periovarian Tissue, Necrosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 4 4 |
Hemorrhage | 2 |
Hyperplasia, Cystic | 2 2 4 3 1 3 2 2 2 3 2 3 4 3 3 2 3 3 3 4 4 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 2 1 1 1 3 1 1 3 |
__________________________________________________________________________|
Lymph Node | |
Iliac, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|
| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10.0 | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG | 7| 8| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 9| 0| 1| 2| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 3 4 4 |
Hyperplasia, Lymphoid | 3 2 2 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 1 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Peripheral Nerve | |
Demyelination | |
__________________________________________________________________________|
Spinal Cord | |
Axon, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 2 2|
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Exudate | |
Inflammation, Acute | |
Glands, Inflammation, Acute | 1 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | |
Hydronephrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|
| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10.0 | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG | 7| 8| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 9| 0| 1| 2| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Metaplasia, Osseous | |
Nephropathy, Chronic | 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1|
Renal Tubule, Atrophy | |
Renal Tubule, Degeneration, Hyaline | 3 |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation, Chronic | |
Serosa, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 3| 3| 8| 3| 4| 3| 3| 1| 3| 3| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 7| |
| 6| 6| 7| 6| 2| 6| 6| 9| 6| 6| 7| 6| 4| 6| 6| 6| 6| 3| 6| 6| 6| 3| 6| 6| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
10.0 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| L |
MG/KG | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M + A + + A + + + M + + + + + + A + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Inflammation, Granulomatous | 3 | 1 3.0|
Perforation | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + A + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Clear Cell Focus | X X | 5 |
Eosinophilic Focus | X X X X X X X X X 3| 22 2.7|
Hematopoietic Cell Proliferation | 2 | 2 1.5|
Mixed Cell Focus | X X X | 6 |
Necrosis | 2 | 1 2.0|
Thrombosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 3 4 | 2 3.5|
Centrilobular, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Fat, Necrosis | 2 2 4 3 | 7 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 | 1 1.0|
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 3 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 2 | 2 2.5|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Mineralization | | 2 1.0|
Ulcer | 2 | 1 2.0|
Glands, Cyst | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 3| 3| 8| 3| 4| 3| 3| 1| 3| 3| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 7| |
| 6| 6| 7| 6| 2| 6| 6| 9| 6| 6| 7| 6| 4| 6| 6| 6| 6| 3| 6| 6| 6| 3| 6| 6| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
10.0 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| L |
MG/KG | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 1 | 5 1.0|
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 | 2 1.5|
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2| 50 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 1 2 2 2 2 1 1 1 1 1 2 1 1 1 1 2| 31 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + M + + + + + + + + + + M + + M + + +| 42 |
Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + M + + + + +| 45 |
Pars Distalis, Angiectasis | 1 1 | 4 1.5|
Pars Distalis, Hyperplasia | 2 1 3 2 1 3 2 2 | 20 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
Follicle, Hypertrophy | | 1 3.0|
Follicular Cell, Hyperplasia | 3 1 1 2 1 1 1 1 1 1 | 21 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
Pigmentation | 2 | 1 2.0|
Arteriole, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 2 | 2 1.5|
Cyst | 2 1 4 2 1 | 14 2.0|
Hemorrhage | 4 | 2 3.5|
Inflammation, Granulomatous | 3 | 1 3.0|
Periovarian Tissue, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 3 4 3 3 | 8 3.5|
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 3| 3| 8| 3| 4| 3| 3| 1| 3| 3| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 7| |
| 6| 6| 7| 6| 2| 6| 6| 9| 6| 6| 7| 6| 4| 6| 6| 6| 6| 3| 6| 6| 6| 3| 6| 6| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
10.0 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| L |
MG/KG | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | 3 3 1 4 4 3 4 2 3 2 3 2 3 3 3 4 4 3 3 4 1 2 4 1| 47 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 1 2 1 1 | 13 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + + | 3 |
Iliac, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 3 1.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 4 3 4 3 3 3 3 3 4 3 | 15 3.5|
Hyperplasia, Lymphoid | 2 3 2 | 8 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Angiectasis | 2 | 1 2.0|
Cyst | | 3 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Inflammation, | | |
Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1| 17 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
Demyelination | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Axon, Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 2 1 | 7 1.6|
Infiltration Cellular, Histiocyte | 2 2 3| 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 3| 3| 8| 3| 4| 3| 3| 1| 3| 3| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 7| |
| 6| 6| 7| 6| 2| 6| 6| 9| 6| 6| 7| 6| 4| 6| 6| 6| 6| 3| 6| 6| 6| 3| 6| 6| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
10.0 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| L |
MG/KG | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Exudate | 1 2 | 2 1.5|
Inflammation, Acute | 1| 1 1.0|
Glands, Inflammation, Acute | 1 1 1 1 1 1| 12 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts Protein | 2 | 1 2.0|
Hydronephrosis | | 1 2.0|
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 36 1.1|
Renal Tubule, Atrophy | 4 | 1 4.0|
Renal Tubule, Degeneration, Hyaline | | 1 3.0|
Renal Tubule, Necrosis | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Arteriole, Inflammation, Chronic | 2 | 1 2.0|
Serosa, Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0|
DAY ON TEST | 3| 1| 3| 7| 3| 3| 3| 3| 3| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0|
| 1| 2| 1| 9| 1| 1| 1| 1| 1| 5| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
| 1| 4| 5| 6| 8| 9| 0| 1| 2| 5| 6| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + A + + + + + + + + + + M + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large, Colon | + A + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + A + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + A + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + A + A + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Clear Cell Focus | X X X X X X X X X X X X X |
Congestion | 2 2 |
Eosinophilic Focus | X X X X X 2 X X 4 X X |
Hyperplasia | 1 |
Inflammation, Chronic | 1 |
Mixed Cell Focus | X X X X X |
Necrosis | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Acinus, Atrophy | 1 2 1 1 1 |
Artery, Inflammation, Chronic | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 1 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + A|
Hemorrhage | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + |
Dysplasia | 2 3 3 4 4 3 3 3 3 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
Hemorrhage | |
Inflammation, Chronic | 1 |
Mineralization | |
Valve, Inflammation, Acute | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0|
DAY ON TEST | 3| 1| 3| 7| 3| 3| 3| 3| 3| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0|
| 1| 2| 1| 9| 1| 1| 1| 1| 1| 5| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
| 1| 4| 5| 6| 8| 9| 0| 1| 2| 5| 6| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + M + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cytoplasmic Alteration | |
Hyperplasia | 2 2 |
Hypertrophy | 1 2 2 1 1 2 1 1 1 1 2 |
Capsule, Hyperplasia | 2 1 2 1 2 3 2 1 2 1 2 1 1 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 1 2 2 3 2 2 3 2 3 3 2 2 1 2 3 2 4 2 1 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + M M + + + + + + + M + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + M + + + + + + + + + M + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + A + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation, Chronic | 1 |
Spermatocele | X X |
__________________________________________________________________________|
Penis | |
Concretion | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 3 2 2 2 |
Inflammation, Acute | |
Inflammation, Chronic | 2 2 2 1 3 2 |
Inflammation, Chronic Active | 2 2 1 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Prostate | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | 3 3 3 3 3 3 4 |
__________________________________________________________________________|
Testes | + + + A + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0|
DAY ON TEST | 3| 1| 3| 7| 3| 3| 3| 3| 3| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0|
| 1| 2| 1| 9| 1| 1| 1| 1| 1| 5| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
| 1| 4| 5| 6| 8| 9| 0| 1| 2| 5| 6| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Mast Cell | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + M|
Angiectasis | 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + M|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 3 |
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + M + M + + + M + + + + + + + + + M + + + M M|
Atrophy | 4 |
Cyst | X X X |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M M M M M M M M M M M M M M M M M + + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Skin, Site of Application, Acanthosis| |
Skin, Site of Application, Ulcer | |
Subcutaneous Tissue, Abscess | 3 |
Subcutaneous Tissue, Hemorrhage | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 4 |
Subcutaneous Tissue, Skin, Site of | |
Application, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Inflammation, Chronic | |
Active | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 3 3 1 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0|
DAY ON TEST | 3| 1| 3| 7| 3| 3| 3| 3| 3| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0|
| 1| 2| 1| 9| 1| 1| 1| 1| 1| 5| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
| 1| 4| 5| 6| 8| 9| 0| 1| 2| 5| 6| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 4 2 |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Inflammation, Acute | |
Polyp, Inflammatory | |
Glands, Inflammation, Acute | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Cyst | |
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Granuloma | |
Hydronephrosis | 2 2 |
Infarct | 2 |
Inflammation, Acute | |
Nephropathy, Chronic | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 1 2 |
Cortex, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Degeneration, Hyaline | |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| |
| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 8| 1| 9| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + M| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.5|
Clear Cell Focus | X X X X X X X X X X X| 24 |
Congestion | 2 | 3 2.0|
Eosinophilic Focus | 2 X X X 2 X X X X| 20 2.5|
Hyperplasia | | 1 1.0|
Inflammation, Chronic | | 1 1.0|
Mixed Cell Focus | X X X X | 9 |
Necrosis | 4 | 2 3.0|
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Acinus, Atrophy | 1 3 2 | 8 1.5|
Artery, Inflammation, Chronic | 2 | 1 2.0|
Duct, Cyst | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Squamous | 2 2 | 4 1.8|
Ulcer | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + | 21 |
Dysplasia | 3 2 2 3 3 4 2 3 3 4 | 21 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 | 2 1.0|
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| |
| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 8| 1| 9| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 1.0|
Mineralization | 1 | 1 1.0|
Valve, Inflammation, Acute | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Cytoplasmic Alteration | 2 | 1 2.0|
Hyperplasia | 2 1 2 1 | 6 1.7|
Hypertrophy | 1 2 1 1 1 1 1 1 2 3 2 1 | 23 1.4|
Capsule, Hyperplasia | 1 1 1 1 1 1 2 3 2 1 1 2 2 1 1 1 1 2 1 2 2 2 1| 43 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2 2 3 2 2 2 3 3 3 2 3 2 2 2 2 2 3 3 2 2 2 2 3| 47 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + M M M + M + + + M + + + + M + + + + +| 37 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + M| 45 |
Pars Distalis, Cyst | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 1 | 1 1.0|
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 | 8 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Granuloma Sperm | 3 | 1 3.0|
Inflammation, Chronic | | 1 1.0|
Spermatocele | | 2 |
__________________________________________________________________________|____________|
Penis | + | 1 |
Concretion | 2 | 1 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Dilatation | 3 2 4 2 2 3 2 2 | 14 2.5|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic | 2 2 2 3 1 2 2 3| 14 2.1|
Inflammation, Chronic Active | 3 4 | 5 2.4|
Metaplasia, Squamous | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| |
| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 8| 1| 9| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 2 2.0|
Hypertrophy | 3 | 8 3.1|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Seminiferous Tubule, Degeneration | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Mast Cell | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 2 1 1 1 2 1| 8 1.3|
__________________________________________________________________________|____________|
Spleen | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 3 3 3 4 | 7 3.1|
Hyperplasia, Lymphoid | | 1 3.0|
Red Pulp, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + M M + M + + + + + + + + M + + + + + +| 39 |
Atrophy | | 1 4.0|
Cyst | | 3 |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 1 | 1 1.0|
Skin, Site of Application, Acanthosis| 2 | 1 2.0|
Skin, Site of Application, Ulcer | 2 | 1 2.0|
Subcutaneous Tissue, Abscess | | 1 3.0|
Subcutaneous Tissue, Hemorrhage | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 4.0|
Subcutaneous Tissue, Skin, Site of | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| |
| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 8| 1| 9| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Application, Inflammation, | | |
Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vertebra, Inflammation, Chronic | | |
Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1| 24 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 4 2.0|
Infiltration Cellular, Histiocyte | 2 2 4 2 2 2 | 8 2.5|
Pigmentation | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia | 2 | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | 2 | 1 2.0|
Inflammation, Acute | 2 | 1 2.0|
Polyp, Inflammatory | 2 | 1 2.0|
Glands, Inflammation, Acute | 1 1 1 1 1 1 1 1 1 | 22 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 4 |
Cyst | X | 1 |
Inflammation, Granulomatous | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X X X X X| 10 |
Granuloma | 1 | 1 1.0|
Hydronephrosis | 2 | 3 2.0|
Infarct | | 1 2.0|
Inflammation, Acute | 2 | 1 2.0|
Nephropathy, Chronic | 2 2 2 2 1 2 1 2 2 2 2 2 2 1 2 2 3 2 1 2 4 2 3| 45 2.0|
Cortex, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| |
| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 8| 1| 9| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Degeneration, Hyaline | 2 | 1 2.0|
Renal Tubule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Calculus Micro Observation Only | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 4| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 8| 3| 2| 3| 0| 0| 3| 3| 3| 3| 0| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 8| 1| 4| 1| 0| 7| 1| 1| 1| 1| 8| 1| 1| 0| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
3.6 | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
MG/KG | 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Clear Cell Focus | X X X X X X X X X X|
Congestion | 1 |
Cyst | X |
Eosinophilic Focus | 2 X X X X X X X X|
Hematopoietic Cell Proliferation | |
Mixed Cell Focus | X X X X X |
Necrosis | |
__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 |
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Hemorrhage | 1 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Tooth | + + + + + + |
Dysplasia | 3 4 4 4 3 4 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1|
Hypertrophy | 1 1 2 1 2 3 2 1 1 |
Capsule, Hyperplasia | 2 2 1 1 1 2 3 2 1 1 2 2 2 1 1 1 2 1 2 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 4| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 8| 3| 2| 3| 0| 0| 3| 3| 3| 3| 0| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 8| 1| 4| 1| 0| 7| 1| 1| 1| 1| 8| 1| 1| 0| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
3.6 | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
MG/KG | 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 2 3 2 2 1 2 3 2 3 2 2 2 3 3 3 3 3 2 3 1 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M M + + + + + M + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M M + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Dilatation | 2|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 4 |
Hemorrhage | 2 |
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 3 3 3 3 |
Inflammation, Chronic | 2 2 2 2 2 3 1|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Giant Cell | |
Granuloma Sperm | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | |
__________________________________________________________________________|
Spleen | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 |
Lymphoid Follicle, Atrophy | |
__________________________________________________________________________|
Thymus | M A + + + M + + + M M M + + + + + + + + + + + + +|
Ectopic Parathyroid Gland | X |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 4| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 8| 3| 2| 3| 0| 0| 3| 3| 3| 3| 0| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 8| 1| 4| 1| 0| 7| 1| 1| 1| 1| 8| 1| 1| 0| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
3.6 | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
MG/KG | 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
Skin, Site of Application, Acanthosis| |
Subcutaneous Tissue, Inflammation, | |
Chronic | 2 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 2 1 |
Infiltration Cellular, Histiocyte | 4 2 |
Alveolar Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2 |
Inflammation, Acute | |
Polyp, Inflammatory | |
Glands, Inflammation, Acute | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X|
Infarct | 2 |
Infiltration Cellular, Lymphocyte | |
Metaplasia, Osseous | |
Nephropathy, Chronic | 2 1 2 2 2 1 2 2 2 2 4 3 2 2 2 2 3 2 2 2 1 2 2|
Cortex, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 4| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 8| 3| 2| 3| 0| 0| 3| 3| 3| 3| 0| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 8| 1| 4| 1| 0| 7| 1| 1| 1| 1| 8| 1| 1| 0| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
3.6 | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
MG/KG | 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X X |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 5| 5| 7| 7| 7| 7| |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 3| 4| 6| 3| 3| 3| 1| |
| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
3.6 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
MG/KG | 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + + + + + A + + + + + + A + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + + + + A + + + + + + A + + + A| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + A + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + A + + + A| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Clear Cell Focus | X X X X X X X X X X X | 21 |
Congestion | | 1 1.0|
Cyst | | 1 |
Eosinophilic Focus | X 3 X X X X X 3 X X X X | 21 2.7|
Hematopoietic Cell Proliferation | 3| 1 3.0|
Mixed Cell Focus | X X X X | 9 |
Necrosis | 1 1 2 2 | 4 1.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 2 | 4 1.3|
Duct, Cyst | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 1.0|
Hemorrhage | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + | 16 |
Dysplasia | 4 3 2 4 3 2 4 3 4 | 15 3.4|
Inflammation, Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 1| 7 1.3|
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 5| 5| 7| 7| 7| 7| |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 3| 4| 6| 3| 3| 3| 1| |
| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
3.6 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
MG/KG | 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 1 3 1 2 1 | 8 1.5|
Hypertrophy | 1 1 3 2 2 1 1 1 2 1 | 19 1.5|
Capsule, Hyperplasia | 1 2 1 2 2 2 1 1 1 1 1 2 3 2 2 1 1 1 2 1 2 2| 43 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 3 2 2 3 3 2 1 2 2 2 2 2 3 1 2 3 3 3 1 1 3 2| 45 2.2|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + + + + M + + + + M + M + + M +| 43 |
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Dilatation | 4 | 2 3.0|
Follicular Cell, Hyperplasia | 1 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 2 3.5|
Hemorrhage | | 1 2.0|
Spermatocele | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 3 3 3 3| 11 2.9|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 1 2 2| 18 1.9|
Inflammation, Chronic Active | 2 | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Giant Cell | 2 | 1 2.0|
Granuloma Sperm | 1| 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 5| 5| 7| 7| 7| 7| |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 3| 4| 6| 3| 3| 3| 1| |
| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
3.6 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
MG/KG | 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M M + + + +| 47 |
Angiectasis | 2 | 2 1.5|
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 4 4| 5 3.4|
Lymphoid Follicle, Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + + + + + + I + + +| 42 |
Ectopic Parathyroid Gland | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M + M M M M M M M M M M M M M M M M M M| 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 2.0|
Skin, Site of Application, Acanthosis| 1 | 1 1.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1| 24 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 5 1.8|
Infiltration Cellular, Histiocyte | 2 | 3 2.7|
Alveolar Epithelium, Hyperplasia | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | 1 | 2 1.5|
Inflammation, Acute | 2 1 | 2 1.5|
Polyp, Inflammatory | 2 | 1 2.0|
Glands, Inflammation, Acute | 1 1 1 1 1 | 12 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 5| 5| 7| 7| 7| 7| |
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 3| 4| 6| 3| 3| 3| 1| |
| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
3.6 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
MG/KG | 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 8 |
Infarct | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2| 1 2.0|
Metaplasia, Osseous | 1 1 | 2 1.0|
Nephropathy, Chronic | 3 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 | 43 2.1|
Cortex, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 40 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 2 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| 3| 7| 7| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 6| 3| 3| 5| 7| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 6| 3|
| 0| 0| 0| 0| 0| 8| 0| 0| 1| 0| 0| 3| 1| 0| 0| 0| 5| 0| 0| 2| 0| 0| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
6.0 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG | 2| 3| 4| 5| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + M + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X X X X X X X |
Eosinophilic Focus | X X X 3 X X X|
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | |
Mixed Cell Focus | X X X X X X |
Necrosis | 2 |
Vacuolization Cytoplasmic | 2 1 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 3 1 1 1 |
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 1|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Infiltration Cellular, Eosinophil | |
Mineralization | 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + +|
Dysplasia | 3 4 3 3 2 3 4 4 3 3 2 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 1 |
Hypertrophy | 2 2 2 2 1 2 3 1 |
Vacuolization Cytoplasmic | 1 |
Capsule, Hyperplasia | 2 2 2 2 1 1 2 2 1 1 1 1 2 1 1 2 2 2 3 3|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| 3| 7| 7| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 6| 3| 3| 5| 7| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 6| 3|
| 0| 0| 0| 0| 0| 8| 0| 0| 1| 0| 0| 3| 1| 0| 0| 0| 5| 0| 0| 2| 0| 0| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
6.0 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG | 2| 3| 4| 5| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 2 2 3 1 3 2 3 2 2 3 2 2 2 3 3 3 2 2 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M M + M|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 4 4 2 2 2 |
Inflammation, Chronic | 2 3 2 2 3 2 2 |
Inflammation, Chronic Active | 4 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 1 |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + M +|
Angiectasis | |
Hematopoietic Cell Proliferation | 3 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
Cyst | |
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7| 3| 7| 7| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 6| 3| 3| 5| 7| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 6| 3|
| 0| 0| 0| 0| 0| 8| 0| 0| 1| 0| 0| 3| 1| 0| 0| 0| 5| 0| 0| 2| 0| 0| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
6.0 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG | 2| 3| 4| 5| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M + M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Skin, Site of Application, | |
Hyperkeratosis | |
Subcutaneous Tissue, Granuloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
Demyelination | 2 |
Gray Matter, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 3 |
Infiltration Cellular, Histiocyte | 1 1 |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2 2 2|
Foreign Body | |
Inflammation, Acute | 1 1 1 1|
Polyp, Inflammatory | 1|
Glands, Inflammation, Acute | 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
Hydronephrosis | 3 |
Infarct | 3 |
Nephropathy, Chronic | 2 2 2 2 2 4 2 2 1 2 2 2 2 2 2 2 1 2 2 1 2 2 2 2 2|
Pigmentation | 2 |
Cortex, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X X X |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| |
| 0| 0| 0| 0| 0| 3| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
6.0 | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
MG/KG | 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X| 1 |
Clear Cell Focus | X X X X X X X X X X X X| 20 |
Eosinophilic Focus | X X X X X X X X X X X 4 X X X| 22 3.5|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Inflammation, Chronic | 2 | 1 2.0|
Mixed Cell Focus | X X X X X X | 12 |
Necrosis | 1 | 2 1.5|
Vacuolization Cytoplasmic | | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Inflammation, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 1 1.0|
Acinus, Atrophy | 2 | 5 1.6|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 | 1 1.0|
Infiltration Cellular, Eosinophil | 2 | 1 2.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + | 26 |
Dysplasia | 4 4 4 4 3 2 4 2 2 4 4 2 2 3 | 26 3.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 | 7 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| |
| 0| 0| 0| 0| 0| 3| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
6.0 | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
MG/KG | 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 6 1.7|
Hypertrophy | 2 1 1 1 2 1 2 2| 16 1.7|
Vacuolization Cytoplasmic | | 1 1.0|
Capsule, Hyperplasia | 2 2 2 1 2 2 1 2 3 2 2 3 3 1 1 2 2 1 2 3 2 3| 43 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 3 3 1 1 2 3 2 3 3 4 3 2 3 2 3 3 2 3 2 3 2 3| 48 2.4|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + M + M + + + + + + + M M + + + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | M M + M M + M + + + + + M + + + + M + + + + + + +| 40 |
Pars Distalis, Cyst | X X | 2 |
Pars Distalis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 1 | 9 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 2 3 3 3 2 3 2 2 2 | 17 2.6|
Inflammation, Chronic | 1 2 2 2 2 2 2 3 2 1 | 17 2.1|
Inflammation, Chronic Active | | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Concretion | | 1 1.0|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| |
| 0| 0| 0| 0| 0| 3| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
6.0 | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
MG/KG | 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 3 3 | 5 3.0|
__________________________________________________________________________|____________|
Thymus | + + M M + + + + + + + M + + + + + + + + + + + + +| 46 |
Cyst | X | 1 |
Ectopic Parathyroid Gland | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Skin, Site of Application, | | |
Hyperkeratosis | 1 | 1 1.0|
Subcutaneous Tissue, Granuloma | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1| 23 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Demyelination | | 1 2.0|
Gray Matter, Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 4 2.0|
Infiltration Cellular, Histiocyte | 2 2 2 1 2| 7 1.6|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | 2 2 2 1 2| 8 1.9|
Foreign Body | 1 | 1 1.0|
Inflammation, Acute | 2 | 5 1.2|
Polyp, Inflammatory | 2 | 2 1.5|
Glands, Inflammation, Acute | 1 1 1 1 1 1 | 11 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| |
| 0| 0| 0| 0| 0| 3| 0| 0| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
6.0 | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
MG/KG | 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X| 8 |
Hydronephrosis | | 1 3.0|
Infarct | | 1 3.0|
Nephropathy, Chronic | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 1 2 2 3 1 2 2 2 2 2| 50 2.0|
Pigmentation | | 1 2.0|
Cortex, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Gross Observation | X | 2 |
Calculus Micro Observation Only | X X X| 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2|
| 9| 9| 0| 9| 1| 9| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
10.0 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1|
MG/KG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Necrosis | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + A + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + A + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Necrosis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X X X X X X X X X X X X X X|
Congestion | 2 2 |
Cyst | |
Eosinophilic Focus | X X X X X X X 2 |
Mixed Cell Focus | X X X X X|
Necrosis | 1 2 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 1 4 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + +|
Dysplasia | 4 3 4 3 3 3 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2|
| 9| 9| 0| 9| 1| 9| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
10.0 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1|
MG/KG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy | 1 1 1 1 1 1 1 2 1|
Capsule, Hyperplasia | 2 1 1 2 1 2 1 1 2 2 2 1 1 2 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 1 2 2 2 3 2 3 2 3 3 3 3 3 3 3 3 2 2 3 4 3|
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + + + + M + + + M + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + M + M + + +|
Pars Distalis, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Follicle, Dilatation | 2 |
Follicular Cell, Hyperplasia | 2 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation, Chronic | 1 |
Inflammation, Granulomatous | |
Spermatocele | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 3 3 2 3 3 3 3 3 |
Inflammation, Chronic | 2 2 2 2 1 2 3 2|
Inflammation, Chronic Active | 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | 2 |
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2|
| 9| 9| 0| 9| 1| 9| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
10.0 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1|
MG/KG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + M +|
Angiectasis | 2 1 1 |
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 4 3 3 |
Hyperplasia, Lymphoid | 3 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + M + M M + + + +|
Cyst | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Skin, Site of Application, Acanthosis| 2 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 2 1 |
Infiltration Cellular, Histiocyte | 3 2 4 1 |
Inflammation, Chronic | 2 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2 1 |
Glands, Inflammation, Acute | 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2|
| 9| 9| 0| 9| 1| 9| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
10.0 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1|
MG/KG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X|
Infarct | |
Metaplasia, Osseous | |
Nephropathy, Acute | 3 |
Nephropathy, Chronic | 2 3 3 2 2 2 2 2 2 2 3 2 2 2 1 2 1 1 2 2 2 1 1|
Cortex, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Degeneration, Hyaline | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + A + + + + + + + + + + + + +|
Calculus Gross Observation | X |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05069-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 16:50:55
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 2| 2| 8| 8| 2| 7| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6| 2| 2| 9| |
| 8| 9| 2| 6| 9| 6| 6| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 0| 9| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
10.0 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| L |
MG/KG | 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A + M + + A A M + + M + + + + + + + + + + A + + +| 41 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + A + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + A + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + A + + + + + + + + + + + + + + A + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + A A + + + + + + + + + + + + + + A + + +| 44 |
Inflammation, Chronic Active | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 3 |
Clear Cell Focus | X X X X X X X X X X X X X | 28 |
Congestion | | 2 2.0|
Cyst | X | 1 |
Eosinophilic Focus | X X | 10 2.0|
Mixed Cell Focus | X X X X X X X X X X X | 16 |
Necrosis | 3 | 3 2.0|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 3 | 2 2.5|
Acinus, Atrophy