National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2850

TDMS Study 05069-08 Pathology Tables

                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE


NTP Experiment-Test: 05069-08                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 03/13/95
Route: DERMAL,SOLUTION                                                                                            Time: 18:33:18


                                                           CORE STUDY


       Facility:  TSI Mason Research

       Chemical CAS #:  147-47-7

       Lock Date:  08/21/92

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25026 Other                             25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All






























a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:33:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                19           10            9            9                                     
    Natural Death                                     12           19           19           19                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                19           21           22           22                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (47)         (48)         (47)                                   
      Erosion                                                       1 (2%)                                                          
   Intestine Large, Rectum                            (49)         (47)         (47)         (46)                                   
      Erosion                                                       1 (2%)                                                          
   Intestine Large, Cecum                             (48)         (43)         (42)         (45)                                   
      Edema                                                                      1 (2%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                    1 (2%)                                
      Ulcer                                                                      1 (2%)                                             
   Intestine Small, Jejunum                           (49)         (41)         (44)         (44)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
   Intestine Small, Ileum                             (45)         (40)         (42)         (40)                                   
      Inflammation, Chronic                                         1 (3%)                                                          
      Metaplasia, Osseous                                           1 (3%)                                                          
      Ulcer                                                         1 (3%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      3 (6%)       1 (2%)       2 (4%)       2 (4%)                                
      Basophilic Focus                                35 (70%)     36 (72%)     32 (64%)     30 (60%)                               
      Clear Cell Focus                                 7 (14%)      7 (14%)      9 (18%)     12 (24%)                               
      Congestion                                                                 1 (2%)                                             
      Eosinophilic Focus                              12 (24%)     16 (32%)     17 (34%)     14 (28%)                               
      Hematopoietic Cell Proliferation                 3 (6%)                                 1 (2%)                                
      Hepatodiaphragmatic Nodule                      11 (22%)      5 (10%)      6 (12%)     16 (32%)                               
      Inflammation, Chronic                                                                   3 (6%)                                
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Mixed Cell Focus                                10 (20%)      6 (12%)      9 (18%)     11 (22%)                               
      Regeneration                                                  1 (2%)       2 (4%)                                             
      Centrilobular, Atrophy                                        1 (2%)                                                          
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Centrilobular, Vacuolization Cytoplasmic        11 (22%)      5 (10%)      6 (12%)      9 (18%)                               
      Midzonal, Vacuolization Cytoplasmic                                                     1 (2%)                                
      Periportal, Vacuolization Cytoplasmic            1 (2%)       1 (2%)                                                          
      Serosa, Inflammation, Acute                                                             1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:33:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Serosa, Necrosis                                                                        1 (2%)                                
   Mesentery                                          (8)          (8)          (4)          (3)                                    
      Inflammation, Chronic                                         1 (13%)      1 (25%)                                            
      Metaplasia, Osseous                                                        1 (25%)                                            
      Fat, Necrosis                                    6 (75%)      7 (88%)      2 (50%)      2 (67%)                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Metaplasia, Hepatocyte                                                                  1 (2%)                                
      Acinus, Atrophy                                 19 (38%)     15 (30%)     14 (28%)     14 (28%)                               
      Acinus, Hyperplasia                                                                     1 (2%)                                
      Artery, Thrombosis                               1 (2%)                                                                       
      Duct, Cyst                                                    1 (2%)                    1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)       1 (2%)                    1 (2%)                                
      Duct, Cyst                                       1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (49)         (50)                                   
      Diverticulum                                                               1 (2%)                                             
      Hyperplasia, Squamous                           13 (26%)     10 (20%)      6 (12%)      7 (14%)                               
      Inflammation, Chronic                            9 (18%)      6 (12%)      5 (10%)      5 (10%)                               
      Perforation                                                                             1 (2%)                                
      Ulcer                                           10 (20%)      8 (16%)      5 (10%)      5 (10%)                               
   Stomach, Glandular                                 (50)         (50)         (50)         (49)                                   
      Erosion                                         13 (26%)      6 (12%)      6 (12%)      7 (14%)                               
      Hyperplasia                                                                1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
      Ulcer                                                         1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  41 (82%)     46 (92%)     43 (86%)     43 (86%)                               
      Mineralization                                   1 (2%)                                                                       
      Atrium, Thrombosis                               3 (6%)       2 (4%)                    2 (4%)                                
      Valve, Thrombosis                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                 1 (2%)                                
      Atrophy                                          1 (2%)                                                                       
      Degeneration                                                                            1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia                                      7 (14%)      4 (8%)       2 (4%)       5 (10%)                               
      Necrosis                                         1 (2%)       1 (2%)                    1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:33:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Vacuolization Cytoplasmic                       13 (26%)     12 (24%)      8 (16%)      8 (16%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      8 (16%)      3 (6%)       3 (6%)       3 (6%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
      Metaplasia, Hepatocyte                                                     1 (2%)       1 (2%)                                
   Parathyroid Gland                                  (44)         (50)         (49)         (48)                                   
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
   Pituitary Gland                                    (49)         (50)         (50)         (50)                                   
      Craniopharyngeal Duct, Pars Intermedia,                                                                                       
          Hyperplasia                                               1 (2%)                                                          
      Pars Distalis, Angiectasis                       9 (18%)     13 (26%)      7 (14%)     11 (22%)                               
      Pars Distalis, Cyst                              6 (12%)      2 (4%)                    1 (2%)                                
      Pars Distalis, Hyperplasia                      11 (22%)     13 (26%)     16 (32%)     11 (22%)                               
      Rathke's Cleft, Cyst                                                                    1 (2%)                                
      Rathke's Cleft, Hemorrhage                                                              1 (2%)                                
   Thyroid Gland                                      (49)         (50)         (48)         (49)                                   
      Hyperplasia                                                                             1 (2%)                                
      C-Cell, Hyperplasia                              9 (18%)     12 (24%)     11 (23%)      4 (8%)                                
      Follicular Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (46)         (45)         (49)                                   
      Cyst                                             3 (6%)       2 (4%)       1 (2%)       2 (4%)                                
      Hyperplasia                                      3 (6%)       1 (2%)                                                          
      Inflammation, Acute                              1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
      Inflammation, Chronic                                                      2 (4%)                                             
      Metaplasia, Squamous                                                       1 (2%)                                             
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cyst                                             8 (16%)      2 (4%)       5 (10%)      7 (14%)                               
      Bilateral, Cyst                                  1 (2%)                                 2 (4%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Cyst                                                          1 (2%)                    1 (2%)                                
      Hyperplasia, Cystic                                                                     1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
   Vagina                                                          (1)          (2)                                                 
      Inflammation, Chronic                                                      1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:33:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)         (50)                                   
      Hyperplasia, Reticulum Cell                                                1 (2%)                                             
      Myelofibrosis                                                 1 (2%)                    1 (2%)                                
   Lymph Node                                         (13)         (10)         (7)          (1)                                    
      Bronchial, Depletion Lymphoid                                 1 (10%)                                                         
      Lumbar, Depletion Lymphoid                                    1 (10%)                                                         
      Mediastinal, Congestion                          1 (8%)                                                                       
      Mediastinal, Ectasia                                          1 (10%)                                                         
      Mediastinal, Hemorrhage                                       3 (30%)                                                         
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                      1 (10%)      1 (14%)                                            
      Pancreatic, Ectasia                                           1 (10%)                                                         
      Pancreatic, Erythrophagocytosis                  1 (8%)                                                                       
      Pancreatic, Pigmentation                                      1 (10%)                                                         
      Renal, Hemorrhage                                1 (8%)                    1 (14%)                                            
   Lymph Node, Mandibular                             (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       3 (6%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Infiltration Cellular, Plasma Cell               2 (4%)       1 (2%)                    1 (2%)                                
   Lymph Node, Mesenteric                             (50)         (49)         (50)         (50)                                   
      Ectasia                                          1 (2%)       1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hemorrhage                                       1 (2%)                                 1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                                                          
      Inflammation, Acute                                                                     1 (2%)                                
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Congestion                                       1 (2%)                                                                       
      Fibrosis                                         6 (12%)      4 (8%)       3 (6%)                                             
      Hematopoietic Cell Proliferation                 3 (6%)       5 (10%)      6 (12%)      4 (8%)                                
      Pigmentation                                     1 (2%)       1 (2%)                                                          
      Capsule, Necrosis                                                                       1 (2%)                                
   Thymus                                             (47)         (50)         (49)         (50)                                   
      Cyst                                                          1 (2%)                    1 (2%)                                
      Ectopic Parathyroid Gland                        2 (4%)                                 1 (2%)                                
      Metaplasia, Osseous                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (49)         (49)         (50)                                   
      Galactocele                                      2 (4%)      10 (20%)      3 (6%)       5 (10%)                               
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (50)                                   
      Acanthosis                                       2 (4%)       1 (2%)       5 (10%)      3 (6%)                                
      Inflammation, Acute                              1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:33:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation, Chronic                            6 (12%)     10 (20%)      8 (16%)      8 (16%)                               
      Necrosis                                                                   1 (2%)                                             
      Necrosis, Chronic                                                                       1 (2%)                                
      Ulcer                                            1 (2%)                                                                       
      Skin, Site of Application, Acanthosis                         1 (2%)       9 (18%)     22 (44%)                               
      Skin, Site of Application, Hyperkeratosis                     1 (2%)       7 (14%)      1 (2%)                                
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic                                                  1 (2%)       2 (4%)       2 (4%)                                
      Subcutaneous Tissue, Foreign Body                                          1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Chronic       2 (4%)       3 (6%)       3 (6%)       1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                       1 (2%)                                                                       
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Inflammation, Chronic           2 (4%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                           2 (4%)                                                                       
      Hyperostosis                                                               1 (2%)                                             
      Cranium, Fracture                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
   Peripheral Nerve                                                             (1)                                                 
      Axon, Degeneration                                                         1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                                    1 (2%)       1 (2%)                                             
      Edema                                                                      1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                5 (10%)      5 (10%)      2 (4%)       3 (6%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            3 (6%)       1 (2%)                    3 (6%)                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Inflammation, Granulomatous                                                             1 (2%)                                
      Alveolar Epithelium, Hyperplasia                              1 (2%)       3 (6%)       2 (4%)                                
      Alveolus, Edema                                               1 (2%)                                                          
      Capillary, Thrombosis                            1 (2%)                                                                       
      Serosa, Fibrosis                                              1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:33:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Nose                                               (50)         (50)         (50)         (49)                                   
      Foreign Body                                     2 (4%)       2 (4%)       2 (4%)       4 (8%)                                
      Fungus                                           2 (4%)       3 (6%)       2 (4%)       2 (4%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Chronic Active                     4 (8%)       6 (12%)      3 (6%)       7 (14%)                               
      Thrombosis                                                    3 (6%)       3 (6%)       1 (2%)                                
      Nasolacrimal Duct, Inflammation, Acute           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (2)          (3)                                    
      Iris, Synechia                                                             1 (50%)                                            
      Lens, Cataract                                                             2 (100%)     3 (100%)                              
      Posterior Chamber, Hemorrhage                                                           1 (33%)                               
      Retina, Atrophy                                                            1 (50%)                                            
      Retina, Degeneration                                                       1 (50%)      2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Accumulation, Hyaline Droplet                    4 (8%)                                                                       
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                          1 (2%)                                                                       
      Inflammation, Acute                                                        1 (2%)                                             
      Nephropathy, Chronic                            49 (98%)     45 (90%)     48 (96%)     49 (98%)                               
      Pigmentation                                                  2 (4%)       1 (2%)       1 (2%)                                
      Papilla, Necrosis                                             1 (2%)                                                          
      Renal Tubule, Hyperplasia                                                  1 (2%)                                             
   Urinary Bladder                                    (50)         (48)         (49)         (50)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:33:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Natural Death                                     21           26           25           23                                     
    Moribund Sacrifice                                24           22           20           26                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 5            2            4            1                                     
  Other                                                                          1                                                  
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (47)         (47)         (42)         (44)                                   
      Inflammation, Acute                                                                     1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
   Intestine Large, Rectum                            (47)         (49)         (49)         (45)                                   
      Angiectasis                                                   1 (2%)                                                          
      Inflammation, Acute                                           2 (4%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Necrosis                                                      1 (2%)                                                          
   Intestine Large, Cecum                             (42)         (44)         (36)         (39)                                   
      Dilatation                                       1 (2%)                                                                       
      Erosion                                                       1 (2%)                                                          
      Inflammation, Acute                              2 (5%)       7 (16%)                   4 (10%)                               
      Necrosis                                         1 (2%)       1 (2%)                    1 (3%)                                
      Ulcer                                                         3 (7%)                    2 (5%)                                
   Intestine Small, Duodenum                          (50)         (50)         (46)         (48)                                   
      Diverticulum                                                               1 (2%)                                             
      Erosion                                                       2 (4%)                    1 (2%)                                
      Inflammation, Chronic Active                                                            2 (4%)                                
      Ulcer                                                                                   1 (2%)                                
   Intestine Small, Jejunum                           (46)         (45)         (42)         (39)                                   
      Inflammation, Acute                              1 (2%)                                                                       
   Intestine Small, Ileum                             (40)         (37)         (34)         (37)                                   
      Diverticulum                                     1 (3%)                                                                       
      Fibrosis                                                                                1 (3%)                                
      Inflammation, Chronic                            1 (3%)       1 (3%)       1 (3%)                                             
      Metaplasia, Osseous                              1 (3%)                                                                       
      Necrosis                                                                                1 (3%)                                
      Ulcer                                                         1 (3%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      6 (12%)      5 (10%)      1 (2%)       1 (2%)                                
      Basophilic Focus                                 8 (16%)      4 (8%)       3 (6%)       4 (8%)                                
      Clear Cell Focus                                 5 (10%)      3 (6%)       3 (6%)       3 (6%)                                
      Congestion                                       1 (2%)                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:33:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Degeneration, Cystic                             3 (6%)       6 (12%)      7 (14%)      2 (4%)                                
      Eosinophilic Focus                                            1 (2%)                    1 (2%)                                
      Hepatodiaphragmatic Nodule                       8 (16%)      7 (14%)      8 (16%)      4 (8%)                                
      Hyperplasia                                                   1 (2%)                                                          
      Infiltration Cellular, Histiocyte                                                       1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                 3 (6%)                                
      Leukocytosis                                                  1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Mixed Cell Focus                                              1 (2%)                    4 (8%)                                
      Necrosis                                         4 (8%)                    2 (4%)       3 (6%)                                
      Regeneration                                                  1 (2%)                    1 (2%)                                
      Centrilobular, Necrosis                          3 (6%)       1 (2%)       2 (4%)       4 (8%)                                
      Centrilobular, Vacuolization Cytoplasmic        12 (24%)      6 (12%)      8 (16%)      7 (14%)                               
      Periportal, Vacuolization Cytoplasmic            4 (8%)                    2 (4%)       4 (8%)                                
      Serosa, Fibrosis                                                           1 (2%)                                             
      Serosa, Necrosis                                                           1 (2%)                                             
   Mesentery                                          (10)         (3)          (3)          (4)                                    
      Hemorrhage                                       2 (20%)                                2 (50%)                               
      Inflammation, Chronic                                                      1 (33%)                                            
      Inflammation, Granulomatous                      1 (10%)                                                                      
      Artery, Angiectasis                                                                     1 (25%)                               
      Fat, Necrosis                                    6 (60%)      2 (67%)      1 (33%)      1 (25%)                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Cytoplasmic Alteration                                        1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Mineralization                                   1 (2%)                                                                       
      Acinus, Atrophy                                 25 (50%)     21 (42%)     20 (40%)     23 (46%)                               
      Acinus, Hyperplasia                              2 (4%)       3 (6%)       4 (8%)       6 (12%)                               
      Artery, Angiectasis                                           2 (4%)                    2 (4%)                                
      Artery, Inflammation, Chronic                    1 (2%)                    1 (2%)                                             
      Artery, Mineralization                                        1 (2%)                    1 (2%)                                
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
      Fibrosis                                                                   1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
      Erosion                                                                    1 (2%)                                             
      Foreign Body                                                               1 (2%)                                             
      Hyperplasia, Squamous                           29 (58%)     34 (68%)     31 (62%)     28 (57%)                               
      Inflammation, Acute                                                        2 (4%)                                             
      Inflammation, Chronic                           17 (34%)     14 (28%)     20 (40%)     14 (29%)                               
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                   1 (2%)       1 (2%)       5 (10%)      2 (4%)                                
      Perforation                                      4 (8%)       5 (10%)      7 (14%)      4 (8%)                                
      Ulcer                                           20 (40%)     25 (50%)     16 (32%)     15 (31%)                               
   Stomach, Glandular                                 (50)         (50)         (50)         (49)                                   
      Erosion                                         13 (26%)     22 (44%)     22 (44%)     17 (35%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:33:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Infiltration Cellular, Lymphocyte                1 (2%)                                 1 (2%)                                
      Inflammation, Chronic                            3 (6%)       1 (2%)       1 (2%)                                             
      Metaplasia, Squamous                             1 (2%)                                                                       
      Mineralization                                  15 (30%)     19 (38%)     20 (40%)     16 (33%)                               
      Ulcer                                            2 (4%)       2 (4%)       3 (6%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)                       (1)                                    
      Aorta, Mineralization                                                                   1 (100%)                              
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  47 (94%)     48 (96%)     48 (96%)     44 (88%)                               
      Inflammation, Acute                                                                     2 (4%)                                
      Mineralization                                  10 (20%)     15 (30%)     13 (26%)      9 (18%)                               
      Thrombosis                                                                              1 (2%)                                
      Atrium, Inflammation, Acute                      2 (4%)                                                                       
      Atrium, Thrombosis                               4 (8%)       5 (10%)      9 (18%)      3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                2 (4%)                                             
      Cytoplasmic Alteration                                                     2 (4%)                                             
      Hemorrhage                                       2 (4%)       2 (4%)       3 (6%)       1 (2%)                                
      Hyperplasia                                      2 (4%)       2 (4%)       2 (4%)       5 (10%)                               
      Hypertrophy                                                   1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
      Necrosis                                         2 (4%)                                                                       
      Vacuolization Cytoplasmic                        9 (18%)     11 (22%)     11 (22%)      9 (18%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     28 (56%)     33 (66%)     30 (60%)     23 (46%)                               
      Mineralization                                                             1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)                                   
      Hyperplasia                                      4 (8%)       1 (2%)                    1 (2%)                                
   Parathyroid Gland                                  (48)         (49)         (46)         (49)                                   
      Hyperplasia                                     18 (38%)     21 (43%)     23 (50%)     23 (47%)                               
      Mineralization                                                1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (49)         (50)         (50)         (49)                                   
      Angiectasis                                                   1 (2%)                    1 (2%)                                
      Mineralization                                                1 (2%)                                                          
      Craniopharyngeal Duct, Hyperplasia                            1 (2%)                                                          
      Craniopharyngeal Duct, Pars Nervosa,                                                                                          
          Hyperplasia                                               1 (2%)                                                          
      Pars Distalis, Angiectasis                       4 (8%)       2 (4%)       4 (8%)       1 (2%)                                
      Pars Distalis, Cyst                              3 (6%)       4 (8%)       6 (12%)      8 (16%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:33:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hemorrhage                                                               1 (2%)                                
      Pars Distalis, Hyperplasia                      11 (22%)     14 (28%)     12 (24%)     14 (29%)                               
      Pars Distalis, Pigmentation                      1 (2%)                    2 (4%)                                             
      Pars Intermedia, Angiectasis                                                            1 (2%)                                
      Pars Intermedia, Cyst                            2 (4%)                    1 (2%)                                             
      Pars Nervosa, Cyst                               1 (2%)       1 (2%)                    1 (2%)                                
      Rathke's Cleft, Cyst                                          1 (2%)                    2 (4%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Cyst                                                                       1 (2%)                                             
      Mineralization                                                1 (2%)                                                          
      C-Cell, Hyperplasia                              4 (8%)       7 (14%)      2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Mediastinum, Necrosis                            1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Atrophy                                                                    1 (2%)                                             
      Granuloma Sperm                                                            2 (4%)                                             
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
   Penis                                              (6)          (10)         (2)          (2)                                    
      Foreign Body                                     1 (17%)                                                                      
      Inflammation, Acute                              2 (33%)      5 (50%)      1 (50%)      1 (50%)                               
      Inflammation, Chronic Active                     1 (17%)                                                                      
      Mineralization                                                1 (10%)                                                         
   Preputial Gland                                    (50)         (49)         (49)         (49)                                   
      Abscess                                                                    1 (2%)                                             
      Cyst                                                          1 (2%)       2 (4%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
      Inflammation, Acute                              5 (10%)      2 (4%)       5 (10%)      8 (16%)                               
      Inflammation, Chronic                            4 (8%)                                 1 (2%)                                
      Inflammation, Chronic Active                                                            1 (2%)                                
      Inflammation, Granulomatous                      1 (2%)                                                                       
   Prostate                                           (50)         (50)         (50)         (49)                                   
      Developmental Malformation                                                 1 (2%)                                             
      Inflammation, Acute                              1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                           23 (46%)     28 (56%)     22 (44%)     24 (49%)                               
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:33:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                                                      2 (4%)                                             
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
      Mineralization                                                2 (4%)       2 (4%)                                             
   Testes                                             (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
      Mineralization                                   2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Arteriole, Inflammation, Chronic                                           1 (2%)                                             
      Interstitial Cell, Hyperplasia                  27 (54%)     22 (44%)     25 (50%)     31 (62%)                               
      Seminiferous Tubule, Degeneration               21 (42%)     25 (50%)     26 (52%)     23 (46%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hypoplasia                                       4 (8%)                                 2 (4%)                                
      Myelofibrosis                                    5 (10%)                                                                      
      Necrosis                                         1 (2%)                                 1 (2%)                                
   Lymph Node                                         (19)         (15)         (6)          (9)                                    
      Mediastinal, Angiectasis                         2 (11%)                                                                      
      Mediastinal, Congestion                          1 (5%)                                 1 (11%)                               
      Mediastinal, Ectasia                             1 (5%)       2 (13%)                                                         
      Mediastinal, Erythrophagocytosis                 2 (11%)      2 (13%)                                                         
      Mediastinal, Hemorrhage                          1 (5%)       3 (20%)      1 (17%)      1 (11%)                               
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                         1 (5%)                                                                       
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                   1 (5%)                                                                       
      Mediastinal, Pigmentation                                                               1 (11%)                               
      Pancreatic, Angiectasis                          1 (5%)       1 (7%)                                                          
      Pancreatic, Congestion                           1 (5%)                                                                       
      Pancreatic, Ectasia                                           1 (7%)                                                          
      Pancreatic, Hemorrhage                           2 (11%)      2 (13%)                                                         
      Pancreatic, Hyperplasia, Lymphoid                             1 (7%)                                                          
      Pancreatic, Infiltration Cellular, Plasma                                                                                     
          Cell                                                                                1 (11%)                               
      Pancreatic, Necrosis                             1 (5%)                                                                       
      Renal, Ectasia                                   1 (5%)                                                                       
      Renal, Hemorrhage                                                                       1 (11%)                               
   Lymph Node, Mandibular                             (49)         (50)         (50)         (50)                                   
      Ectasia                                                                    1 (2%)                                             
      Erythrophagocytosis                                           1 (2%)                                                          
      Hemorrhage                                       1 (2%)                    1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                            2 (4%)                                                                       
      Infiltration Cellular, Plasma Cell               5 (10%)                                2 (4%)                                
      Infiltration Cellular, Histiocyte                             1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:33:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Necrosis                                         1 (2%)                                                                       
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)                                   
      Angiectasis                                      2 (4%)       1 (2%)                    2 (4%)                                
      Congestion                                       1 (2%)                                                                       
      Depletion Lymphoid                               1 (2%)       1 (2%)                    1 (2%)                                
      Ectasia                                          5 (10%)      3 (6%)       6 (12%)      3 (6%)                                
      Erythrophagocytosis                              2 (4%)       2 (4%)                    2 (4%)                                
      Hemorrhage                                       3 (6%)       5 (10%)      2 (4%)       2 (4%)                                
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                             1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibrosis                                        11 (22%)     12 (24%)     12 (24%)     13 (26%)                               
      Hematopoietic Cell Proliferation                 2 (4%)       7 (14%)      6 (12%)      2 (4%)                                
      Necrosis                                                                                2 (4%)                                
      Pigmentation                                     2 (4%)                                                                       
      Capsule, Necrosis                                             2 (4%)       4 (8%)                                             
      Lymphoid Follicle, Depletion Cellular                         1 (2%)                                                          
      Red Pulp, Thrombosis                             1 (2%)                                                                       
   Thymus                                             (45)         (44)         (49)         (46)                                   
      Angiectasis                                                   1 (2%)                                                          
      Ectopic Parathyroid Gland                                                  3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (42)         (42)         (45)         (40)                                   
      Galactocele                                     12 (29%)      5 (12%)      3 (7%)       2 (5%)                                
   Skin                                               (50)         (50)         (49)         (50)                                   
      Acanthosis                                       9 (18%)      5 (10%)      6 (12%)      7 (14%)                               
      Hyperkeratosis                                                1 (2%)       1 (2%)       5 (10%)                               
      Inflammation, Acute                              2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic                                         2 (4%)       1 (2%)       1 (2%)                                
      Ulcer                                            1 (2%)       1 (2%)                    1 (2%)                                
      Skin, Site of Application, Acanthosis            1 (2%)       4 (8%)      14 (29%)     21 (42%)                               
      Skin, Site of Application, Cyst Epithelial                                                                                    
          Inclusion                                                 1 (2%)                                                          
      Skin, Site of Application, Hyperkeratosis        2 (4%)       2 (4%)       2 (4%)       3 (6%)                                
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic                                                  3 (6%)                                                          
      Subcutaneous Tissue, Hemorrhage                                                         1 (2%)                                
      Subcutaneous Tissue, Inflammation, Acute         1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Chronic       1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                    1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Skin, Site of                                                                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:33:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
          Application, Fibrosis                        1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                          21 (42%)     24 (48%)     27 (54%)     25 (50%)                               
      Inflammation, Chronic                                                                   1 (2%)                                
      Osteomalacia                                                                            1 (2%)                                
      Mandible, Cyst                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       4 (8%)       2 (4%)       3 (6%)       1 (2%)                                
      Inflammation, Acute                                                                     1 (2%)                                
      Cerebrum, Necrosis                                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       1 (2%)       1 (2%)                                                          
      Emphysema                                                                               2 (4%)                                
      Hemorrhage                                       7 (14%)      9 (18%)      5 (10%)      4 (8%)                                
      Infiltration Cellular, Histiocyte               10 (20%)     13 (26%)     15 (30%)     15 (30%)                               
      Inflammation, Acute                                           2 (4%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic                            3 (6%)                                 3 (6%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                   2 (4%)       7 (14%)      6 (12%)      6 (12%)                               
      Thrombosis                                                                              1 (2%)                                
      Alveolar Epithelium, Hyperplasia                              3 (6%)       1 (2%)       1 (2%)                                
      Alveolus, Edema                                  4 (8%)       3 (6%)       9 (18%)      5 (10%)                               
      Capillary, Thrombosis                                                      4 (8%)                                             
   Nose                                               (50)         (49)         (50)         (50)                                   
      Foreign Body                                    15 (30%)     11 (22%)      9 (18%)      9 (18%)                               
      Fungus                                          19 (38%)     21 (43%)     13 (26%)     10 (20%)                               
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Chronic Active                    26 (52%)     24 (49%)     22 (44%)     16 (32%)                               
      Thrombosis                                       2 (4%)                    1 (2%)                                             
      Ulcer                                            2 (4%)       4 (8%)                    2 (4%)                                
      Vein, Thrombosis                                 1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 18:33:18  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (3)          (3)                                                 
      Anterior Chamber, Inflammation, Acute                         1 (33%)                                                         
      Choroid, Mineralization                                       1 (33%)                                                         
      Cornea, Inflammation, Acute                                   1 (33%)                                                         
      Iris, Synechia                                                             1 (33%)                                            
      Lens, Cataract                                   1 (100%)     3 (100%)     3 (100%)                                           
      Retina, Degeneration                                          2 (67%)      1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cyst                                            13 (26%)     10 (20%)     17 (34%)     20 (40%)                               
      Hydronephrosis                                   1 (2%)                                                                       
      Infarct                                          1 (2%)                                 1 (2%)                                
      Inflammation, Acute                                                                     2 (4%)                                
      Mineralization                                   3 (6%)       2 (4%)       5 (10%)      4 (8%)                                
      Nephropathy, Chronic                            50 (100%)    50 (100%)    49 (98%)     50 (100%)                              
      Pigmentation                                                  2 (4%)       1 (2%)                                             
      Cortex, Mineralization                                                     1 (2%)                                             
      Renal Tubule, Degeneration, Hyaline                                                     1 (2%)                                
      Renal Tubule, Hyperplasia                        2 (4%)                    6 (12%)      3 (6%)                                
      Vein, Thrombosis                                                           1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (50)         (48)                                   
      Calculus Gross Observation                       2 (4%)                                 1 (2%)                                
      Calculus Micro Observation Only                                                         1 (2%)                                
      Hemorrhage                                       1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Acute                                           1 (2%)                    1 (2%)                                
      Inflammation, Chronic                            1 (2%)                    1 (2%)       1 (2%)                                
      Mineralization                                                1 (2%)                    1 (2%)                                
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.