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TDMS Study 05069-08 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: TSI Mason Research                      1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)                    DATE: 04/03/96       
EXPERIMENT: 05069 TEST: 08                                                                                     TIME: 04:32:18       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-95256                              ROUTE: DERMAL,SOLUTION                                         NTP C#: 60902D       
PATHOLOGIST: K. MURTHY                       VOELKER, FRANK                                                    CAS: 147-47-7        
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: TSI Mason Research                      1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)                    DATE: 04/03/96       
EXPERIMENT: 05069 TEST: 08                                                                                     TIME: 04:32:18       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-95256                              ROUTE: DERMAL,SOLUTION                                         NTP C#: 60902D       
PATHOLOGIST: K. MURTHY                       VOELKER, FRANK                                                    CAS: 147-47-7        




                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    

                                                    ----------------

                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: TSI Mason Research                      1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)                    DATE: 04/03/96       
EXPERIMENT: 05069 TEST: 08                                                                                     TIME: 04:32:18       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-95256                              ROUTE: DERMAL,SOLUTION                                         NTP C#: 60902D       
PATHOLOGIST: K. MURTHY                       VOELKER, FRANK                                                    CAS: 147-47-7        




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                             IN THE ANALYSIS OF THE STUDY OF 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

              ====================================================================================================

                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Islets, Pancreatic            Adenoma
              Kidney: Renal Tubule          Adenoma
                                            Carcinoma or Adenoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
                                            Carcinoma or Adenoma
              Testes                        Adenoma
              All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors

              ====================================================================================================

                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Adrenal Medulla               Pheochromocytoma: Benign, Complex, Malignant, NOS
              Mammary Gland                 Fibroadenoma
                                            Fibroma, Fibroadenoma or Adenoma
                                            Fibroma, Fibroadenoma, Carcinoma, or Adenoma
              Thyroid Gland: C-Cell         Adenoma
                                            Carcinoma or Adenoma
              All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors

              ====================================================================================================
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE   1
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  1/60 (2%)    1/60 (2%)    2/60 (3%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.6%         4.8%         9.1%         3.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    1/21 (5%)    2/22 (9%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   604          736 (T)      736 (T)      708       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.574      P=0.744N     P=0.540      P=0.757N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.563      P=0.717      P=0.508      P=0.738    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.550      P=0.762N     P=0.509      P=0.761N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.545                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.752N     P=0.500      P=0.752N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)    7/60 (12%)   7/60 (12%)   2/60 (3%)  |  4/60 (7%)    1/60 (2%)    1/60 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |  34.5%        62.5%        54.3%        34.5%      |  14.7%         4.5%         2.5%         4.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     1/2 (50%)    1/4 (25%)    0/1 (0%)   |  1/19 (5%)    0/21 (0%)    0/22 (0%)    1/22 (5%)  |
|FIRST INCIDENCE (DAYS) |   649          568          462 (I)      445       |   581          734          609          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.484N     P=0.289      P=0.251      P=0.494N   |  P=0.084N     P=0.186N     P=0.172N     P=0.172N   |
|INCIDENTAL TUMOR       |  P=0.301N     P=0.471      P=0.322      P=0.397N   |  P=0.097N     P=0.204N     P=0.207N     P=0.189N   |
|LOGISTIC REGRESSION    |  P=0.265N     P=0.396      P=0.341      P=0.297N   |  P=0.087N     P=0.178N     P=0.174N     P=0.176N   |
|COCHRAN-ARMITAGE       |  P=0.195N                                          |  P=0.090N                                          |
|FISHER EXACT           |               P=0.381      P=0.381      P=0.219N   |               P=0.182N     P=0.182N     P=0.182N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE   2
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    0/60 (0%)    0/60 (0%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%        18.3%         0.0%         0.0%      |   3.3%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          653          ---          ---       |   698          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.580N     P=0.228        (e)          (e)      |  P=0.218N     P=0.521N     P=0.514N     P=0.507N   |
|INCIDENTAL TUMOR       |  P=0.547N     P=0.237        (e)          (e)      |  P=0.230N     P=0.500N     P=0.513N     P=0.541N   |
|LOGISTIC REGRESSION    |  P=0.534N     P=0.229        (e)          (e)      |  P=0.210N     P=0.500N     P=0.494N     P=0.498N   |
|COCHRAN-ARMITAGE       |  P=0.455N                                          |  P=0.212N                                          |
|FISHER EXACT           |               P=0.248        (e)          (e)      |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/60 (8%)    9/60 (15%)   7/60 (12%)   2/60 (3%)  |  5/60 (8%)    1/60 (2%)    1/60 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |  34.5%        69.4%        54.3%        34.5%      |  17.5%         4.5%         2.5%         4.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     1/2 (50%)    1/4 (25%)    0/1 (0%)   |  1/19 (5%)    0/21 (0%)    0/22 (0%)    1/22 (5%)  |
|FIRST INCIDENCE (DAYS) |   649          568          462 (I)      445       |   581          734          609          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.460N     P=0.142      P=0.251      P=0.494N   |  P=0.039N*    P=0.115N     P=0.104N     P=0.103N   |
|INCIDENTAL TUMOR       |  P=0.276N     P=0.254      P=0.322      P=0.397N   |  P=0.047N*    P=0.117N     P=0.123N     P=0.117N   |
|LOGISTIC REGRESSION    |  P=0.236N     P=0.202      P=0.341      P=0.297N   |  P=0.039N*    P=0.102N     P=0.099N     P=0.100N   |
|COCHRAN-ARMITAGE       |  P=0.163N                                          |  P=0.041N*                                         |
|FISHER EXACT           |               P=0.197      P=0.381      P=0.219N   |               P=0.103N     P=0.103N     P=0.103N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE   3
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    2/59 (3%)    3/59 (5%)    1/59 (2%)  |  5/59 (8%)    2/56 (4%)    5/55 (9%)    2/59 (3%)  |
|ADJUSTED (b)           |   5.3%         5.0%        18.3%         2.2%      |  17.4%        10.0%        22.4%         7.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  1/19 (5%)    2/20 (10%)   4/21 (19%)   1/22 (5%)  |
|FIRST INCIDENCE (DAYS) |   653          568          575          519       |   461 (I)      736 (T)      730          701       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.442      P=0.501      P=0.259      P=0.719    |  P=0.201N     P=0.217N     P=0.589N     P=0.207N   |
|INCIDENTAL TUMOR       |  P=0.540      P=0.632      P=0.286      P=0.689    |  P=0.235N     P=0.221N     P=0.610      P=0.248N   |
|LOGISTIC REGRESSION    |  P=0.524      P=0.500      P=0.287      P=0.759    |  P=0.230N     P=0.239N     P=0.611      P=0.213N   |
|COCHRAN-ARMITAGE       |  P=0.540                                           |  P=0.241N                                          |
|FISHER EXACT           |               P=0.494      P=0.303      P=0.748    |               P=0.241N     P=0.583      P=0.219N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/59 (2%)    1/59 (2%)    2/59 (3%)  |  1/59 (2%)    0/56 (0%)    0/55 (0%)    0/59 (0%)  |
|ADJUSTED (b)           |   0.0%         6.7%         5.9%        21.4%      |   3.3%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/20 (0%)    0/21 (0%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          653          653          378       |   698          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.088      P=0.453      P=0.478      P=0.201    |  P=0.218N     P=0.521N     P=0.514N     P=0.507N   |
|INCIDENTAL TUMOR       |  P=0.089      P=0.500      P=0.455      P=0.173    |  P=0.238N     P=0.513N     P=0.541N     P=0.541N   |
|LOGISTIC REGRESSION    |  P=0.130      P=0.502      P=0.486      P=0.248    |  P=0.213N     P=0.511N     P=0.507N     P=0.498N   |
|COCHRAN-ARMITAGE       |  P=0.132                                           |  P=0.215N                                          |
|FISHER EXACT           |               P=0.496      P=0.496      P=0.244    |               P=0.513N     P=0.518N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE   4
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    3/59 (5%)    4/59 (7%)    3/59 (5%)  |  6/59 (10%)   2/56 (4%)    5/55 (9%)    2/59 (3%)  |
|ADJUSTED (b)           |   5.3%        11.3%        23.1%        23.1%      |  20.2%        10.0%        22.4%         7.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  1/19 (5%)    2/20 (10%)   4/21 (19%)   1/22 (5%)  |
|FIRST INCIDENCE (DAYS) |   653          568          575          378       |   461 (I)      736 (T)      730          701       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.135      P=0.286      P=0.145      P=0.245    |  P=0.123N     P=0.142N     P=0.466N     P=0.133N   |
|INCIDENTAL TUMOR       |  P=0.176      P=0.411      P=0.151      P=0.200    |  P=0.149N     P=0.140N     P=0.534N     P=0.163N   |
|LOGISTIC REGRESSION    |  P=0.208      P=0.309      P=0.163      P=0.312    |  P=0.140N     P=0.152N     P=0.523N     P=0.132N   |
|COCHRAN-ARMITAGE       |  P=0.219                                           |  P=0.150N                                          |
|FISHER EXACT           |               P=0.303      P=0.177      P=0.303    |               P=0.153N     P=0.550N     P=0.136N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/60 (10%)   2/60 (3%)    0/59 (0%)    3/60 (5%)  |  0/60 (0%)    0/60 (0%)    1/60 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |  37.8%         8.7%         0.0%        15.4%      |   0.0%         0.0%         4.5%         4.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/21 (0%)    1/22 (5%)    1/22 (5%)  |
|FIRST INCIDENCE (DAYS) |   521          563          ---          596       |   ---          ---          736 (T)      736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.232N     P=0.208N     P=0.041N*    P=0.518N   |  P=0.225        (e)        P=0.529      P=0.529    |
|INCIDENTAL TUMOR       |  P=0.145N     P=0.156N     P=0.043N*    P=0.328N   |  P=0.225        (e)        P=0.529      P=0.529    |
|LOGISTIC REGRESSION    |  P=0.136N     P=0.124N     P=0.022N*    P=0.328N   |  P=0.225        (e)        P=0.529      P=0.529    |
|COCHRAN-ARMITAGE       |  P=0.107N                                          |  P=0.206                                           |
|FISHER EXACT           |               P=0.136N     P=0.014N*    P=0.245N   |                 (e)        P=0.500      P=0.500    |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE   5
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    1/59 (2%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         5.1%        25.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     1/4 (25%)    0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          462 (I)      729 (T)      ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.600      P=0.244      P=0.455        (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.590N     P=0.306      P=0.455        (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.543N     P=0.207      P=0.455        (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.533N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.248      P=0.496        (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/60 (10%)   4/60 (7%)    1/59 (2%)    3/60 (5%)  |  0/60 (0%)    0/60 (0%)    1/60 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |  37.8%        13.3%        25.0%        15.4%      |   0.0%         0.0%         4.5%         4.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     1/4 (25%)    0/1 (0%)   |  0/19 (0%)    0/21 (0%)    1/22 (5%)    1/22 (5%)  |
|FIRST INCIDENCE (DAYS) |   521          462 (I)      729 (T)      596       |   ---          ---          736 (T)      736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.269N     P=0.462N     P=0.119N     P=0.518N   |  P=0.225        (e)        P=0.529      P=0.529    |
|INCIDENTAL TUMOR       |  P=0.161N     P=0.378N     P=0.130N     P=0.328N   |  P=0.225        (e)        P=0.529      P=0.529    |
|LOGISTIC REGRESSION    |  P=0.139N     P=0.354N     P=0.073N     P=0.328N   |  P=0.225        (e)        P=0.529      P=0.529    |
|COCHRAN-ARMITAGE       |  P=0.111N                                          |  P=0.206                                           |
|FISHER EXACT           |               P=0.372N     P=0.060N     P=0.245N   |                 (e)        P=0.500      P=0.500    |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE   6
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    7/60 (12%)  10/60 (17%)   8/60 (13%) |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |  20.0%        71.6%        70.8%        38.4%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/5 (20%)    1/2 (50%)    2/4 (50%)    0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      563          575          601       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.009 **   P=0.003 **   P=0.003 ** |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.005 **   P=0.016 *    P=0.006 **   P=0.024 *  |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.005 **   P=0.029 *    P=0.003 **   P=0.009 ** |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.020 *                                         |    (e)                                             |
|FISHER EXACT           |               P=0.031 *    P=0.004 **   P=0.016 *  |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    8/60 (13%)  10/60 (17%)   8/60 (13%) |  0/60 (0%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |  20.0%        73.3%        70.8%        38.4%      |   0.0%         0.0%         0.0%         4.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  1/5 (20%)    1/2 (50%)    2/4 (50%)    0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    1/22 (5%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      563          575          601       |   ---          ---          ---          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.001 **   P=0.004 **   P=0.003 **   P=0.003 ** |  P=0.209        (e)          (e)        P=0.529    |
|INCIDENTAL TUMOR       |  P=0.007 **   P=0.008 **   P=0.006 **   P=0.024 *  |  P=0.210        (e)          (e)        P=0.529    |
|LOGISTIC REGRESSION    |  P=0.006 **   P=0.016 *    P=0.003 **   P=0.009 ** |  P=0.210        (e)          (e)        P=0.529    |
|COCHRAN-ARMITAGE       |  P=0.026 *                                         |  P=0.197                                           |
|FISHER EXACT           |               P=0.016 *    P=0.004 **   P=0.016 *  |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE   7
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    2/60 (3%)    0/60 (0%)    0/60 (0%)  |  0/60 (0%)    2/60 (3%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%        11.4%         0.0%         0.0%      |   0.0%         6.7%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          600          ---          ---       |   ---          622          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.534N     P=0.207        (e)          (e)      |  P=0.444N     P=0.256        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.449N     P=0.306        (e)          (e)      |  P=0.470N     P=0.185        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.479N     P=0.244        (e)          (e)      |  P=0.452N     P=0.238        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.455N                                          |  P=0.455N                                          |
|FISHER EXACT           |               P=0.248        (e)          (e)      |               P=0.248        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    0/60 (0%)    2/60 (3%)    1/60 (2%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   8.3%         0.0%         6.1%         2.4%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   679          ---          575          543       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.402      P=0.557N     P=0.462      P=0.696    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.505      P=0.500N     P=0.598      P=0.689    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.469      P=0.507N     P=0.492      P=0.751    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.478                                           |    (e)                                             |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.752N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE   8
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    2/60 (3%)    2/60 (3%)    1/60 (2%)  |  0/60 (0%)    2/60 (3%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   8.3%        11.4%         6.1%         2.4%      |   0.0%         6.7%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   679          600          575          543       |   ---          622          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.493      P=0.433      P=0.462      P=0.696    |  P=0.444N     P=0.256        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.557N     P=0.570      P=0.598      P=0.689    |  P=0.470N     P=0.185        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.580      P=0.509      P=0.492      P=0.751    |  P=0.452N     P=0.238        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.581N                                          |  P=0.455N                                          |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.752N   |               P=0.248        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    2/60 (3%)    2/60 (3%)    1/60 (2%)  |  0/60 (0%)    2/60 (3%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   8.3%        11.4%         6.1%         2.4%      |   0.0%         6.7%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   679          600          575          543       |   ---          622          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.493      P=0.433      P=0.462      P=0.696    |  P=0.444N     P=0.256        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.557N     P=0.570      P=0.598      P=0.689    |  P=0.470N     P=0.185        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.580      P=0.509      P=0.492      P=0.751    |  P=0.452N     P=0.238        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.581N                                          |  P=0.455N                                          |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.752N   |               P=0.248        (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE   9
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/59 (0%)    0/60 (0%)  |  2/60 (3%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   8.0%         0.0%         4.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  1/19 (5%)    0/21 (0%)    0/22 (0%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   654          ---          727          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.132N     P=0.226N     P=0.459N     P=0.224N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.151N     P=0.229N     P=0.498N     P=0.246N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.139N     P=0.237N     P=0.489N     P=0.235N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.142N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.248N     P=0.500N     P=0.248N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    1/59 (2%)    0/60 (0%)  |  2/60 (3%)    0/60 (0%)    1/60 (2%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         2.8%         0.0%      |   8.0%         0.0%         4.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/9 (0%)     0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  1/19 (5%)    0/21 (0%)    0/22 (0%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          585          ---       |   654          ---          727          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.590        (e)        P=0.500        (e)      |  P=0.132N     P=0.226N     P=0.459N     P=0.224N   |
|INCIDENTAL TUMOR       |  P=0.673        (e)        P=0.607        (e)      |  P=0.151N     P=0.229N     P=0.498N     P=0.246N   |
|LOGISTIC REGRESSION    |  P=0.599        (e)        P=0.497        (e)      |  P=0.139N     P=0.237N     P=0.489N     P=0.235N   |
|COCHRAN-ARMITAGE       |  P=0.598                                           |  P=0.142N                                          |
|FISHER EXACT           |                 (e)        P=0.496        (e)      |               P=0.248N     P=0.500N     P=0.248N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE  10
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |  1/60 (2%)    0/60 (0%)    1/60 (2%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         8.6%         0.0%      |   2.1%         0.0%         3.4%         4.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    1/22 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          590          ---       |   498          ---          697          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.436        (e)        P=0.225        (e)      |  P=0.552      P=0.513N     P=0.752      P=0.749N   |
|INCIDENTAL TUMOR       |  P=0.488        (e)        P=0.270        (e)      |  P=0.536      P=0.419N     P=0.743N     P=0.744N   |
|LOGISTIC REGRESSION    |  P=0.467        (e)        P=0.233        (e)      |  P=0.546      P=0.503N     P=0.756      P=0.761    |
|COCHRAN-ARMITAGE       |  P=0.485                                           |  P=0.545                                           |
|FISHER EXACT           |                 (e)        P=0.248        (e)      |               P=0.500N     P=0.752N     P=0.752N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |  3/60 (5%)    5/60 (8%)    0/60 (0%)    3/60 (5%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |  10.2%        19.5%         0.0%        12.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  1/19 (5%)    3/21 (14%)   0/22 (0%)    2/22 (9%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   500          655          ---          708       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.335N     P=0.383      P=0.115N     P=0.631N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.369N     P=0.413      P=0.106N     P=0.660N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.363N     P=0.357      P=0.121N     P=0.659N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.371N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.359      P=0.122N     P=0.660N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE  11
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    0/60 (0%)    2/60 (3%)    0/60 (0%)  |  4/60 (7%)    5/60 (8%)    1/60 (2%)    4/60 (7%)  |
|ADJUSTED (b)           |   0.0%         0.0%         8.6%         0.0%      |  12.0%        19.5%         3.4%        16.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  1/19 (5%)    3/21 (14%)   0/22 (0%)    3/22 (14%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          590          ---       |   498          655          697          708       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.436        (e)        P=0.225        (e)      |  P=0.386N     P=0.519      P=0.181N     P=0.607N   |
|INCIDENTAL TUMOR       |  P=0.488        (e)        P=0.270        (e)      |  P=0.426N     P=0.583      P=0.151N     P=0.632N   |
|LOGISTIC REGRESSION    |  P=0.467        (e)        P=0.233        (e)      |  P=0.415N     P=0.500      P=0.183N     P=0.640N   |
|COCHRAN-ARMITAGE       |  P=0.485                                           |  P=0.422N                                          |
|FISHER EXACT           |                 (e)        P=0.248        (e)      |               P=0.500      P=0.182N     P=0.641N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    0/60 (0%)    1/60 (2%)  | 25/60 (42%)  16/60 (27%)  15/60 (25%)  17/60 (28%) |
|ADJUSTED (b)           |   0.0%         5.0%         0.0%         5.0%      |  72.6%        55.7%        56.7%        50.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   | 11/19 (58%)   9/21 (43%)  11/22 (50%)   7/22 (32%) |
|FIRST INCIDENCE (DAYS) |   ---          649          ---          624       |   427          638          691          461 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.262      P=0.455        (e)        P=0.419    |  P=0.046N*    P=0.054N     P=0.022N*    P=0.078N   |
|INCIDENTAL TUMOR       |  P=0.360      P=0.500        (e)        P=0.623    |  P=0.053N     P=0.052N     P=0.020N*    P=0.084N   |
|LOGISTIC REGRESSION    |  P=0.332      P=0.505        (e)        P=0.481    |  P=0.050N     P=0.048N*    P=0.023N*    P=0.077N   |
|COCHRAN-ARMITAGE       |  P=0.362                                           |  P=0.071N                                          |
|FISHER EXACT           |               P=0.500        (e)        P=0.500    |               P=0.062N     P=0.040N*    P=0.090N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE  12
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    2/60 (3%)    1/60 (2%)  | 26/60 (43%)  16/60 (27%)  15/60 (25%)  17/60 (28%) |
|ADJUSTED (b)           |   0.0%         5.0%         8.6%         5.0%      |  73.2%        55.7%        56.7%        50.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   | 11/19 (58%)   9/21 (43%)  11/22 (50%)   7/22 (32%) |
|FIRST INCIDENCE (DAYS) |   ---          649          590          624       |   427          638          691          461 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.199      P=0.455      P=0.225      P=0.419    |  P=0.033N*    P=0.040N*    P=0.015N*    P=0.059N   |
|INCIDENTAL TUMOR       |  P=0.285      P=0.500      P=0.270      P=0.623    |  P=0.035N*    P=0.032N*    P=0.012N*    P=0.058N   |
|LOGISTIC REGRESSION    |  P=0.259      P=0.505      P=0.233      P=0.481    |  P=0.034N*    P=0.033N*    P=0.015N*    P=0.054N   |
|COCHRAN-ARMITAGE       |  P=0.290                                           |  P=0.049N*                                         |
|FISHER EXACT           |               P=0.500      P=0.248      P=0.500    |               P=0.042N*    P=0.027N*    P=0.064N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    2/60 (3%)    1/60 (2%)  | 29/60 (48%)  20/60 (33%)  15/60 (25%)  20/60 (33%) |
|ADJUSTED (b)           |   0.0%         5.0%         8.6%         5.0%      |  77.8%        65.4%        56.7%        58.3%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%) |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   | 12/19 (63%)  11/21 (52%)  11/22 (50%)   9/22 (41%) |
|FIRST INCIDENCE (DAYS) |   ---          649          590          624       |   427          638          691          461 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.199      P=0.455      P=0.225      P=0.419    |  P=0.025N*    P=0.066N     P=0.004N**   P=0.063N   |
|INCIDENTAL TUMOR       |  P=0.285      P=0.500      P=0.270      P=0.623    |  P=0.025N*    P=0.044N*    P=0.002N**   P=0.058N   |
|LOGISTIC REGRESSION    |  P=0.259      P=0.505      P=0.233      P=0.481    |  P=0.024N*    P=0.053N     P=0.003N**   P=0.056N   |
|COCHRAN-ARMITAGE       |  P=0.290                                           |  P=0.038N*                                         |
|FISHER EXACT           |               P=0.500      P=0.248      P=0.500    |               P=0.068N     P=0.007N**   P=0.068N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE  13
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 30/58 (52%)  23/60 (38%)  23/60 (38%)  19/58 (33%) | 35/59 (59%)  31/60 (52%)  35/60 (58%)  38/60 (63%) |
|ADJUSTED (b)           |  75.7%       100.0%        61.9%       100.0%      |  85.3%        84.5%        79.6%        81.1%      |
|INTERIM SACRIFICE 1 (c)|  5/9 (56%)    0/10 (0%)    4/10 (40%)   1/9 (11%)  |  5/10 (50%)   3/10 (30%)   4/10 (40%)   5/10 (50%) |
|TERMINAL (d)           |  1/5 (20%)    2/2 (100%)   0/4 (0%)     1/1 (100%) | 14/19 (74%)  16/21 (76%)  14/22 (64%)  14/22 (64%) |
|FIRST INCIDENCE (DAYS) |   428          471          455          445       |   427          461 (I)      457          461 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.333N     P=0.285N     P=0.262N     P=0.346N   |  P=0.426      P=0.241N     P=0.415N     P=0.517    |
|INCIDENTAL TUMOR       |  P=0.021N*    P=0.143N     P=0.100N     P=0.030N*  |  P=0.308      P=0.216N     P=0.455N     P=0.413    |
|LOGISTIC REGRESSION    |  P=0.029N*    P=0.104N     P=0.094N     P=0.032N*  |  P=0.305      P=0.239N     P=0.498N     P=0.411    |
|COCHRAN-ARMITAGE       |  P=0.027N*                                         |  P=0.286                                           |
|FISHER EXACT           |               P=0.101N     P=0.101N     P=0.030N*  |               P=0.256N     P=0.531N     P=0.397    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/58 (0%)    1/60 (2%)    0/60 (0%)    0/58 (0%)  |  2/59 (3%)    0/60 (0%)    2/60 (3%)    1/60 (2%)  |
|ADJUSTED (b)           |   0.0%         7.7%         0.0%         0.0%      |   9.6%         0.0%         9.1%         3.2%      |
|INTERIM SACRIFICE 1 (c)|  0/9 (0%)     0/10 (0%)    0/10 (0%)    0/9 (0%)   |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  1/19 (5%)    0/21 (0%)    2/22 (9%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          660          ---          ---       |   729          ---          736 (T)      685       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.659N     P=0.447        (e)          (e)      |  P=0.444N     P=0.229N     P=0.647N     P=0.483N   |
|INCIDENTAL TUMOR       |  P=0.637N     P=0.510        (e)          (e)      |  P=0.465N     P=0.222N     P=0.655N     P=0.516N   |
|LOGISTIC REGRESSION    |  P=0.615N     P=0.511        (e)          (e)      |  P=0.462N     P=0.229N     P=0.665N     P=0.487N   |
|COCHRAN-ARMITAGE       |  P=0.578N                                          |  P=0.469N                                          |
|FISHER EXACT           |               P=0.508        (e)          (e)      |               P=0.244N     P=0.684N     P=0.494N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE  14
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 30/58 (52%)  24/60 (40%)  23/60 (38%)  19/58 (33%) | 37/59 (63%)  31/60 (52%)  37/60 (62%)  39/60 (65%) |
|ADJUSTED (b)           |  75.7%       100.0%        61.9%       100.0%      |  88.8%        84.5%        84.7%        81.7%      |
|INTERIM SACRIFICE 1 (c)|  5/9 (56%)    0/10 (0%)    4/10 (40%)   1/9 (11%)  |  5/10 (50%)   3/10 (30%)   4/10 (40%)   5/10 (50%) |
|TERMINAL (d)           |  1/5 (20%)    2/2 (100%)   0/4 (0%)     1/1 (100%) | 15/19 (79%)  16/21 (76%)  16/22 (73%)  14/22 (64%) |
|FIRST INCIDENCE (DAYS) |   428          471          455          445       |   427          461 (I)      457          461 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.328N     P=0.343N     P=0.262N     P=0.346N   |  P=0.462      P=0.154N     P=0.400N     P=0.535N   |
|INCIDENTAL TUMOR       |  P=0.020N*    P=0.191N     P=0.100N     P=0.030N*  |  P=0.341      P=0.115N     P=0.437N     P=0.482    |
|LOGISTIC REGRESSION    |  P=0.026N*    P=0.139N     P=0.094N     P=0.032N*  |  P=0.341      P=0.132N     P=0.485N     P=0.491    |
|COCHRAN-ARMITAGE       |  P=0.024N*                                         |  P=0.318                                           |
|FISHER EXACT           |               P=0.137N     P=0.101N     P=0.030N*  |               P=0.151N     P=0.529N     P=0.472    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    3/60 (5%)    5/60 (8%)    3/60 (5%)  |  0/60 (0%)    1/60 (2%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |  14.3%        14.8%        22.4%        24.6%      |   0.0%         3.7%         0.0%         4.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    1/22 (5%)  |
|FIRST INCIDENCE (DAYS) |   630          598          585          619       |   ---          713          ---          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.280      P=0.584      P=0.270      P=0.439    |  P=0.367      P=0.500        (e)        P=0.529    |
|INCIDENTAL TUMOR       |  P=0.505      P=0.517N     P=0.386      P=0.626N   |  P=0.355      P=0.500        (e)        P=0.529    |
|LOGISTIC REGRESSION    |  P=0.411      P=0.649N     P=0.335      P=0.573    |  P=0.363      P=0.500        (e)        P=0.529    |
|COCHRAN-ARMITAGE       |  P=0.494                                           |  P=0.362                                           |
|FISHER EXACT           |               P=0.660N     P=0.359      P=0.660N   |               P=0.500        (e)        P=0.500    |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE  15
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    2/60 (3%)    1/60 (2%)    1/60 (2%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   6.3%        10.4%         3.1%         2.8%      |   3.3%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   667          640          613          565       |   698          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.543      P=0.419      P=0.722      P=0.686    |  P=0.218N     P=0.521N     P=0.514N     P=0.507N   |
|INCIDENTAL TUMOR       |  P=0.499N     P=0.570      P=0.730N     P=0.748N   |  P=0.230N     P=0.500N     P=0.513N     P=0.541N   |
|LOGISTIC REGRESSION    |  P=0.570N     P=0.507      P=0.754      P=0.748    |  P=0.210N     P=0.500N     P=0.494N     P=0.498N   |
|COCHRAN-ARMITAGE       |  P=0.535N                                          |  P=0.212N                                          |
|FISHER EXACT           |               P=0.500      P=0.752N     P=0.752N   |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    2/60 (3%)    1/60 (2%)    2/60 (3%)  |  1/60 (2%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   6.3%        10.4%         3.1%        22.2%      |   3.3%         0.0%         0.0%         3.7%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   667          640          613          565       |   698          ---          ---          708       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.291      P=0.419      P=0.722      P=0.384    |  P=0.634      P=0.521N     P=0.514N     P=0.757    |
|INCIDENTAL TUMOR       |  P=0.421      P=0.570      P=0.730N     P=0.470    |  P=0.599      P=0.500N     P=0.513N     P=0.717    |
|LOGISTIC REGRESSION    |  P=0.364      P=0.507      P=0.754      P=0.441    |  P=0.641      P=0.500N     P=0.494N     P=0.761N   |
|COCHRAN-ARMITAGE       |  P=0.419                                           |  P=0.638                                           |
|FISHER EXACT           |               P=0.500      P=0.752N     P=0.500    |               P=0.500N     P=0.500N     P=0.752N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE  16
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    1/60 (2%)    2/60 (3%)    0/60 (0%)  |  0/60 (0%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   9.2%         2.5%         6.3%         0.0%      |   0.0%         3.7%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   630          598          585          ---       |   ---          713          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.271N     P=0.542N     P=0.641      P=0.364N   |  P=0.590N     P=0.500        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.122N     P=0.359N     P=0.567N     P=0.213N   |  P=0.608N     P=0.500        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.209N     P=0.490N     P=0.687      P=0.276N   |  P=0.576N     P=0.500        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.195N                                          |  P=0.577N                                          |
|FISHER EXACT           |               P=0.500N     P=0.691N     P=0.248N   |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/60 (2%)    2/60 (3%)    2/60 (3%)    3/60 (5%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |   5.6%        12.6%        12.8%        24.6%      |   0.0%         0.0%         0.0%         4.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    1/22 (5%)  |
|FIRST INCIDENCE (DAYS) |   656          610          651          619       |   ---          ---          ---          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.100      P=0.429      P=0.424      P=0.173    |  P=0.209        (e)          (e)        P=0.529    |
|INCIDENTAL TUMOR       |  P=0.174      P=0.570      P=0.421      P=0.333    |  P=0.210        (e)          (e)        P=0.529    |
|LOGISTIC REGRESSION    |  P=0.150      P=0.509      P=0.475      P=0.232    |  P=0.210        (e)          (e)        P=0.529    |
|COCHRAN-ARMITAGE       |  P=0.214                                           |  P=0.197                                           |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.309    |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE  17
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    3/60 (5%)    4/60 (7%)    3/60 (5%)  |  0/60 (0%)    1/60 (2%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |  14.3%        14.8%        18.3%        24.6%      |   0.0%         3.7%         0.0%         4.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    1/22 (5%)  |
|FIRST INCIDENCE (DAYS) |   630          598          585          619       |   ---          713          ---          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.321      P=0.584      P=0.408      P=0.439    |  P=0.367      P=0.500        (e)        P=0.529    |
|INCIDENTAL TUMOR       |  P=0.560      P=0.517N     P=0.555      P=0.626N   |  P=0.355      P=0.500        (e)        P=0.529    |
|LOGISTIC REGRESSION    |  P=0.451      P=0.649N     P=0.480      P=0.573    |  P=0.363      P=0.500        (e)        P=0.529    |
|COCHRAN-ARMITAGE       |  P=0.528                                           |  P=0.362                                           |
|FISHER EXACT           |               P=0.660N     P=0.500      P=0.660N   |               P=0.500        (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/60 (5%)    3/60 (5%)    4/60 (7%)    3/60 (5%)  |  0/60 (0%)    1/60 (2%)    0/60 (0%)    1/60 (2%)  |
|ADJUSTED (b)           |  14.3%        14.8%        18.3%        24.6%      |   0.0%         3.7%         0.0%         4.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    1/22 (5%)  |
|FIRST INCIDENCE (DAYS) |   630          598          585          619       |   ---          713          ---          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.321      P=0.584      P=0.408      P=0.439    |  P=0.367      P=0.500        (e)        P=0.529    |
|INCIDENTAL TUMOR       |  P=0.560      P=0.517N     P=0.555      P=0.626N   |  P=0.355      P=0.500        (e)        P=0.529    |
|LOGISTIC REGRESSION    |  P=0.451      P=0.649N     P=0.480      P=0.573    |  P=0.363      P=0.500        (e)        P=0.529    |
|COCHRAN-ARMITAGE       |  P=0.528                                           |  P=0.362                                           |
|FISHER EXACT           |               P=0.660N     P=0.500      P=0.660N   |               P=0.500        (e)        P=0.500    |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE  18
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 41/60 (68%)  49/60 (82%)  44/60 (73%)  48/60 (80%) |                                                    |
|ADJUSTED (b)           | 100.0%       100.0%        97.6%       100.0%      |                                                    |
|INTERIM SACRIFICE 1 (c)|  5/10 (50%)   8/10 (80%)   7/10 (70%)   7/10 (70%) |                                                    |
|TERMINAL (d)           |  5/5 (100%)   2/2 (100%)   3/4 (75%)    1/1 (100%) |                                                    |
|FIRST INCIDENCE (DAYS) |   462 (I)      462 (I)      462 (I)      462 (I)   |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.004 **   P=0.064      P=0.190      P=0.004 ** |                                                    |
|INCIDENTAL TUMOR       |  P=0.049 *    P=0.181      P=0.382      P=0.072    |                                                    |
|LOGISTIC REGRESSION    |  P=0.065      P=0.116      P=0.313      P=0.051    |                                                    |
|COCHRAN-ARMITAGE       |  P=0.135                                           |                                                    |
|FISHER EXACT           |               P=0.070      P=0.344      P=0.105    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |  7/59 (12%)   5/60 (8%)    2/58 (3%)    2/59 (3%)  |
|ADJUSTED (b)           |   0.0%        25.0%         0.0%         0.0%      |  31.2%        19.5%         9.1%         9.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  5/19 (26%)   3/21 (14%)   2/22 (9%)    2/22 (9%)  |
|FIRST INCIDENCE (DAYS) |   ---          725          ---          ---       |   568          655          736 (T)      736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.729      P=0.455        (e)          (e)      |  P=0.018N*    P=0.334N     P=0.053N     P=0.054N   |
|INCIDENTAL TUMOR       |  P=0.643N     P=0.500        (e)          (e)      |  P=0.021N*    P=0.360N     P=0.064N     P=0.058N   |
|LOGISTIC REGRESSION    |  P=0.711N     P=0.453        (e)          (e)      |  P=0.027N*    P=0.373N     P=0.078N     P=0.076N   |
|COCHRAN-ARMITAGE       |  P=0.577N                                          |  P=0.031N*                                         |
|FISHER EXACT           |               P=0.500        (e)          (e)      |               P=0.369N     P=0.085N     P=0.081N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE  19
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |  7/59 (12%)   5/60 (8%)    3/58 (5%)    2/59 (3%)  |
|ADJUSTED (b)           |   0.0%        25.0%         0.0%         0.0%      |  31.2%        19.5%        13.6%         9.1%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  5/19 (26%)   3/21 (14%)   3/22 (14%)   2/22 (9%)  |
|FIRST INCIDENCE (DAYS) |   ---          725          ---          ---       |   568          655          736 (T)      736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.729      P=0.455        (e)          (e)      |  P=0.023N*    P=0.334N     P=0.108N     P=0.054N   |
|INCIDENTAL TUMOR       |  P=0.643N     P=0.500        (e)          (e)      |  P=0.027N*    P=0.360N     P=0.126N     P=0.058N   |
|LOGISTIC REGRESSION    |  P=0.711N     P=0.453        (e)          (e)      |  P=0.036N*    P=0.373N     P=0.154N     P=0.076N   |
|COCHRAN-ARMITAGE       |  P=0.577N                                          |  P=0.041N*                                         |
|FISHER EXACT           |               P=0.500        (e)          (e)      |               P=0.369N     P=0.168N     P=0.081N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    0/60 (0%)    0/60 (0%)  |  1/59 (2%)    2/60 (3%)    0/58 (0%)    1/59 (2%)  |
|ADJUSTED (b)           |   0.0%         6.7%         0.0%         0.0%      |   2.9%         6.1%         0.0%         4.5%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    1/22 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          653          ---          ---       |   654          608          ---          736 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.635N     P=0.453        (e)          (e)      |  P=0.469N     P=0.515      P=0.483N     P=0.744N   |
|INCIDENTAL TUMOR       |  P=0.643N     P=0.500        (e)          (e)      |  P=0.498N     P=0.441      P=0.527N     P=0.754    |
|LOGISTIC REGRESSION    |  P=0.612N     P=0.504        (e)          (e)      |  P=0.476N     P=0.505      P=0.502N     P=0.760N   |
|COCHRAN-ARMITAGE       |  P=0.577N                                          |  P=0.481N                                          |
|FISHER EXACT           |               P=0.500        (e)          (e)      |               P=0.506      P=0.504N     P=0.752N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE  20
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  4/60 (7%)    4/60 (7%)    4/60 (7%)    0/60 (0%)  |
|ADJUSTED (b)           |                                                    |  15.2%        10.8%        17.2%         0.0%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  2/19 (11%)   1/21 (5%)    3/22 (14%)   0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   576          461 (I)      730          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.054N     P=0.613N     P=0.577N     P=0.054N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.061N     P=0.621      P=0.617N     P=0.062N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.065N     P=0.643      P=0.628N     P=0.062N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.067N                                          |
|FISHER EXACT           |                                                    |               P=0.641N     P=0.641N     P=0.059N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  4/60 (7%)    5/60 (8%)    4/60 (7%)    1/60 (2%)  |
|ADJUSTED (b)           |                                                    |  15.2%        13.2%        17.2%         1.7%      |
|INTERIM SACRIFICE 1 (c)|                                                    |  0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |                                                    |  2/19 (11%)   1/21 (5%)    3/22 (14%)   0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   576          461 (I)      730          336       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.115N     P=0.532      P=0.577N     P=0.162N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.138N     P=0.479      P=0.617N     P=0.179N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.134N     P=0.500      P=0.628N     P=0.182N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.135N                                          |
|FISHER EXACT           |                                                    |               P=0.500      P=0.641N     P=0.182N   |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE  21
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 25/60 (42%)  26/60 (43%)  19/60 (32%)  14/60 (23%) | 22/60 (37%)  16/60 (27%)  23/60 (38%)  10/60 (17%) |
|ADJUSTED (b)           |  93.4%       100.0%        75.3%        63.9%      |  64.2%        52.7%        72.4%        32.8%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    1/10 (10%)   2/10 (20%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  4/5 (80%)    2/2 (100%)   1/4 (25%)    0/1 (0%)   |  9/19 (47%)   8/21 (38%)  14/22 (64%)   4/22 (18%) |
|FIRST INCIDENCE (DAYS) |   428          462 (I)      455          487       |   272          557          492          540       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.266N     P=0.310      P=0.374N     P=0.389N   |  P=0.018N*    P=0.150N     P=0.503N     P=0.012N*  |
|INCIDENTAL TUMOR       |  P=0.020N*    P=0.440      P=0.276N     P=0.091N   |  P=0.018N*    P=0.188N     P=0.472      P=0.011N*  |
|LOGISTIC REGRESSION    |  P=0.017N*    P=0.575N     P=0.181N     P=0.040N*  |  P=0.017N*    P=0.153N     P=0.540      P=0.010N** |
|COCHRAN-ARMITAGE       |  P=0.011N*                                         |  P=0.025N*                                         |
|FISHER EXACT           |               P=0.500      P=0.172N     P=0.025N*  |               P=0.163N     P=0.500      P=0.011N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/60 (3%)    4/60 (7%)    2/60 (3%)    2/60 (3%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   4.2%        12.7%         6.2%       100.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     1/1 (100%) |  0/19 (0%)    0/21 (0%)    0/22 (0%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   462 (I)      554          459          612       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.550      P=0.383      P=0.689      P=0.550    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.454N     P=0.363      P=0.608      P=0.613    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.470N     P=0.302      P=0.676N     P=0.695    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.479N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.340      P=0.691N     P=0.691N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE  22
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    2/60 (3%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         4.2%         5.1%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          641          381          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.496      P=0.492      P=0.231        (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.612N     P=0.623      P=0.203        (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.589      P=0.506      P=0.259        (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.570                                           |    (e)                                             |
|FISHER EXACT           |               P=0.500      P=0.248        (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma or Osteoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/60 (0%)    1/60 (2%)    2/60 (3%)    0/60 (0%)  |  0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)  |
|ADJUSTED (b)           |   0.0%         4.2%         5.1%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|INTERIM SACRIFICE 1 (c)|  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |  0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)  |
|TERMINAL (d)           |  0/5 (0%)     0/2 (0%)     0/4 (0%)     0/1 (0%)   |  0/19 (0%)    0/21 (0%)    0/22 (0%)    0/22 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          641          381          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.496      P=0.492      P=0.231        (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.612N     P=0.623      P=0.203        (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.589      P=0.506      P=0.259        (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.570                                           |    (e)                                             |
|FISHER EXACT           |               P=0.500      P=0.248        (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE  23
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 55/60 (92%)  58/60 (97%)  54/60 (90%)  55/60 (92%) | 49/60 (82%)  41/60 (68%)  41/60 (68%)  44/60 (73%) |
|ADJUSTED (b)           | 100.0%       100.0%        98.1%       100.0%      |  95.8%        95.0%        94.9%        87.5%      |
|INTERIM SACRIFICE 1 (c)|  7/10 (70%)   8/10 (80%)   9/10 (90%)   8/10 (80%) |  6/10 (60%)   4/10 (40%)   4/10 (40%)   6/10 (60%) |
|TERMINAL (d)           |  5/5 (100%)   2/2 (100%)   3/4 (75%)    1/1 (100%) | 17/19 (89%)  19/21 (90%)  20/22 (91%)  16/22 (73%) |
|FIRST INCIDENCE (DAYS) |   428          462 (I)      455          445       |   427          461 (I)      457          461 (I)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.032 *    P=0.203      P=0.357      P=0.034 *  |  P=0.158N     P=0.114N     P=0.078N     P=0.191N   |
|INCIDENTAL TUMOR       |  P=0.532      P=0.244      P=0.624N     P=0.500    |  P=0.155N     P=0.067N     P=0.039N*    P=0.191N   |
|LOGISTIC REGRESSION    |  P=0.549N     P=0.397      P=0.563N     P=0.590    |  P=0.153N     P=0.054N     P=0.045N*    P=0.190N   |
|COCHRAN-ARMITAGE       |  P=0.421N                                          |  P=0.191N                                          |
|FISHER EXACT           |               P=0.219      P=0.500N     P=0.628N   |               P=0.070N     P=0.070N     P=0.191N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 28/60 (47%)  36/60 (60%)  26/60 (43%)  21/60 (35%) | 30/60 (50%)  26/60 (43%)  29/60 (48%)  18/60 (30%) |
|ADJUSTED (b)           |  94.3%       100.0%        93.6%       100.0%      |  76.4%        72.6%        81.4%        50.8%      |
|INTERIM SACRIFICE 1 (c)|  1/10 (10%)   2/10 (20%)   2/10 (20%)   0/10 (0%)  |  0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)  |
|TERMINAL (d)           |  4/5 (80%)    2/2 (100%)   3/4 (75%)    1/1 (100%) | 11/19 (58%)  12/21 (57%)  16/22 (73%)   7/22 (32%) |
|FIRST INCIDENCE (DAYS) |   428          462 (I)      381          378       |   272          485          447          336       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.415      P=0.068      P=0.477      P=0.364    |  P=0.022N*    P=0.265N     P=0.351N     P=0.025N*  |
|INCIDENTAL TUMOR       |  P=0.113N     P=0.091      P=0.545      P=0.343N   |  P=0.017N*    P=0.326N     P=0.516N     P=0.016N*  |
|LOGISTIC REGRESSION    |  P=0.081N     P=0.137      P=0.451N     P=0.188N   |  P=0.016N*    P=0.278N     P=0.456N     P=0.018N*  |
|COCHRAN-ARMITAGE       |  P=0.050N*                                         |  P=0.024N*                                         |
|FISHER EXACT           |               P=0.100      P=0.427N     P=0.133N   |               P=0.292N     P=0.500N     P=0.020N*  |
|=================================================================================================================================|
         DATE: 04/03/96                     EXPERIMENT: 05069 TEST: 08                                                 PAGE  24
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 MG/KG      36 MG/KG     60 MG/KG     100       |   0 MG/KG      36 MG/KG     60 MG/KG     100       |
|                       |                                          MG/KG     |                                          MG/KG     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 55/60 (92%)  59/60 (98%)  55/60 (92%)  57/60 (95%) | 55/60 (92%)  47/60 (78%)  52/60 (87%)  49/60 (82%) |
|ADJUSTED (b)           | 100.0%       100.0%        98.1%       100.0%      |  98.2%        97.9%        98.1%        90.6%      |
|INTERIM SACRIFICE 1 (c)|  7/10 (70%)   9/10 (90%)   9/10 (90%)   8/10 (80%) |  6/10 (60%)   4/10 (40%)   5/10 (50%)   6/10 (60%) |
|TERMINAL (d)           |  5/5 (100%)   2/2 (100%)   3/4 (75%)    1/1 (100%) | 18/19 (95%)  20/21 (95%)  21/22 (95%)  17/22 (77%) |
|FIRST INCIDENCE (DAYS) |   428          462 (I)      381          378       |   272          461 (I)      447          336       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.020 *    P=0.174      P=0.318      P=0.022 *  |  P=0.177N     P=0.132N     P=0.240N     P=0.171N   |
|INCIDENTAL TUMOR       |  P=0.214      P=0.117      P=0.457      P=0.181    |  P=0.136N     P=0.026N*    P=0.270N     P=0.096N   |
|LOGISTIC REGRESSION    |  P=0.311      P=0.201      P=0.594      P=0.278    |  P=0.108N     P=0.022N*    P=0.203N     P=0.080N   |
|COCHRAN-ARMITAGE       |  P=0.409                                           |  P=0.145N                                          |
|FISHER EXACT           |               P=0.103      P=0.628N     P=0.359    |               P=0.036N*    P=0.279N     P=0.089N   |
|=================================================================================================================================|

 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (c)  Observed incidence at interim kill.
          Male interim sacrifices(days):   462
          Female interim sacrifices(days): 461
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.

  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.