TDMS Study 05069-08 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: TSI Mason Research 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER) DATE: 04/03/96
EXPERIMENT: 05069 TEST: 08 TIME: 04:42:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-95256 ROUTE: DERMAL,SOLUTION NTP C#: 60902D
PATHOLOGIST: K. MURTHY VOELKER, FRANK CAS: 147-47-7
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: TSI Mason Research 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER) DATE: 04/03/96
EXPERIMENT: 05069 TEST: 08 TIME: 04:42:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-95256 ROUTE: DERMAL,SOLUTION NTP C#: 60902D
PATHOLOGIST: K. MURTHY VOELKER, FRANK CAS: 147-47-7
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 45 CENSORED DEATHS 10 TERMINAL 5 |
| |
| UNCENSORED DEATHS |
| 393 428 435 492 498 507 513 521 522 527 |
| 542 557 563 564 603 610 613 616 618 620 |
| 624 625 630 631 637 649 650 650 652 652 |
| 652 653 656 662 667 668 668 675 679 683 |
| 687 689 691 709 722 |
| CENSORED DEATHS |
| 462 462 462 462 462 462 462 462 462 462 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 36 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 48 CENSORED DEATHS 10 TERMINAL 2 |
| |
| UNCENSORED DEATHS |
| 471 504 554 563 568 571 580 592 592 594 |
| 598 600 601 603 603 609 610 613 613 619 |
| 625 626 627 630 639 640 641 641 645 647 |
| 649 649 650 650 651 653 653 660 660 663 |
| 675 693 702 704 716 718 725 728 |
| CENSORED DEATHS |
| 462 462 462 462 462 462 462 462 462 462 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 60 MG/KG |
| --------------------- |
| |
| TOTAL 59 UNCENSORED DEATHS 45 CENSORED DEATHS 10 TERMINAL 4 |
| |
| UNCENSORED DEATHS |
| 381 455 459 522 526 550 553 568 570 570 |
| 570 575 575 585 590 603 612 613 616 617 |
| 619 620 621 622 628 629 630 643 644 646 |
| 647 651 653 653 655 661 665 667 668 675 |
| 680 692 693 697 703 |
| CENSORED DEATHS |
| 462 462 462 462 462 462 462 462 462 462 |
| |
==================================================================================
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 MG/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 49 CENSORED DEATHS 10 TERMINAL 1 |
| |
| UNCENSORED DEATHS |
| 339 378 445 487 519 530 536 542 543 546 |
| 550 555 560 564 565 596 596 599 599 601 |
| 601 602 603 609 612 614 618 618 619 622 |
| 624 628 630 630 633 635 648 651 653 654 |
| 654 662 668 673 691 693 697 719 723 |
| CENSORED DEATHS |
| 462 462 462 462 462 462 462 462 462 462 |
| |
==================================================================================
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 98.3 95.0 78.8 70.7 32.3 10.1 |
| | |
| | |
|36 MG/KG | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 70.0 20.0 4.0 |
| | |
| | |
|60 MG/KG | 100.0 100.0 100.0 100.0 98.3 94.9 90.8 68.1 24.8 8.3 |
| | |
| | |
|100 | 100.0 100.0 100.0 98.3 96.7 95.0 82.9 54.6 16.2 2.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 36 MG/KG 60 MG/KG 100 |
| MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 10.1% 4.0% 8.3% 2.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.046 P=0.598 P=0.694 P=0.068 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 606.7 629.5 610.5 598.7 |
|NATURAL DEATHS (C) | (11.8) ( 7.5) (10.0) (10.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 592.8 604.9 593.4 578.1 |
|(STANDARD ERROR) | (12.4) (10.5) (11.5) (11.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 31 CENSORED DEATHS 10 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 272 427 498 500 527 554 563 568 576 581 |
| 591 604 606 621 625 646 654 663 679 696 |
| 698 702 704 716 719 721 722 723 729 734 |
| 735 |
| CENSORED DEATHS |
| 461 461 461 461 461 461 461 461 461 461 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 36 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 29 CENSORED DEATHS 10 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 292 454 485 487 492 505 524 554 557 608 |
| 622 635 638 647 649 655 667 672 673 687 |
| 688 688 692 713 714 714 719 725 734 |
| CENSORED DEATHS |
| 461 461 461 461 461 461 461 461 461 461 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 60 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 28 CENSORED DEATHS 10 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 447 457 492 492 540 551 560 588 602 607 |
| 609 619 626 659 663 664 668 689 690 691 |
| 694 697 698 709 712 727 730 734 |
| CENSORED DEATHS |
| 461 461 461 461 461 461 461 461 461 461 |
| |
==================================================================================
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 MG/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 28 CENSORED DEATHS 10 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 336 410 448 484 540 579 581 583 598 602 |
| 626 627 632 641 644 646 655 675 676 685 |
| 688 701 704 708 708 714 716 722 |
| CENSORED DEATHS |
| 461 461 461 461 461 461 461 461 461 461 |
| |
==================================================================================
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 736 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 98.3 98.3 96.7 90.6 76.5 64.4 38.3 |
| | |
| | |
|36 MG/KG | 100.0 100.0 100.0 98.3 98.3 94.7 86.6 82.6 68.5 42.3 |
| | |
| | |
|60 MG/KG | 100.0 100.0 100.0 100.0 100.0 96.7 90.6 82.6 68.5 44.3 |
| | |
| | |
|100 | 100.0 100.0 100.0 98.3 96.7 93.0 91.0 80.9 66.7 44.5 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 36 MG/KG 60 MG/KG 100 |
| MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 38.3% 42.3% 44.3% 44.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.690N P=0.911N P=0.711N P=0.765N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 624.3 616.9 629.1 618.9 |
|NATURAL DEATHS (C) | (18.9) (19.5) (16.1) (18.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 632.5 632.6 640.3 635.5 |
|(STANDARD ERROR) | (15.3) (15.4) (14.3) (15.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
36 MG/KG = 2
60 MG/KG = 3
100 MG/KG = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 4 3 1 2
| 4 4 3 1 114 33 2 2
| 14 3 412 3 22
| 411 33 22
90 + 111 434 3
| 1 1 443 22
| 2 2
| 11
80 + 1 141 22
| 1133
| 44 33 22
| 1 3 3 1
P 70 + 4 3411
E | 22
R | 11
C | 22
E 60 + 11
N | 44
T | 11
| 4432 2
S 50 + 1 1
U | 44
R | 3 211
V | 33
I 40 + 44
V |
A | 31 1
L | 44 11
30 + 22 3
| 4 4 11
| 42 23
| 11
20 + 23211
| 4 4 232
| 444 1 21
| 4 332121
10 + 33 1 1
| 443 22 3
| 4 42 2
| 4 4
0 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 39 obs hidden.
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
36 MG/KG = 2
60 MG/KG = 3
100 MG/KG = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 4 3
| 1 2 4 4 1 3 23 231
| 4 4
| 221 1 3
90 + 2 2 1 331 4
| 2 2 311143
P | 113 3
E | 2 32
R 80 + 1 142 24
C | 1 1 2322
E | 1 13422 3
N | 11
T 70 + 1 412
| 11 124 3
S | 121
U | 1421
R 60 + 433
V | 411
I | 23121
V |
A 50 + 3 3
L | 211 3
| 1 13
| 22
40 +
| 11
|
|
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 59 obs hidden.