TDMS Study 05070-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
VINYL TOLUENE
NTP Experiment-Test: 05070-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:43
Facility: Midwest Research Institute
Chemical CAS #: 25013154
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund Sacrifice 6 10 1
Natural Death 8 2 7
Accidently Killed 1 2
Dosing Accident 6
Survivors
Terminal Sacrifice 36 37 34
Animals Examined Microscopically 48 49 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (38) (2) (42)
Dilatation 1 (3%) 1 (50%)
Infiltration Cellular, Lymphocyte 2 (5%) 1 (2%)
Intestine Large, Cecum (45) (2) (43)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Intestine Large, Colon (47) (2) (46)
Serosa, Inflammation, Chronic Active,
Multifocal 1 (2%)
Intestine Small (46) (6) (47)
Peyer's Patch, Hyperplasia, Lymphoid 2 (4%) 1 (17%)
Intestine Small, Duodenum (45) (3) (44)
Serosa, Ileum, Jejunum, Inflammation,
Chronic Active, Multifocal 1 (2%)
Liver (48) (16) (49)
Angiectasis, Focal 1 (6%)
Clear Cell Focus 1 (2%)
Cytomegaly, Focal 1 (2%)
Eosinophilic Focus 1 (2%)
Fatty Change, Diffuse 1 (2%) 1 (2%)
Granuloma, Multifocal 2 (4%)
Hematocyst 1 (6%)
Hematopoietic Cell Proliferation, Multifocal 3 (6%) 1 (2%)
Hemorrhage, Multifocal 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Diffuse, Lymphocyte 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 5 (10%) 3 (6%)
Infiltration Cellular, Mixed Cell 1 (2%) 1 (2%)
Inflammation, Multifocal, Subacute 8 (17%) 5 (10%)
Necrosis, Multifocal 2 (4%) 1 (2%)
Vacuolization Cytoplasmic, Diffuse 1 (2%)
Vacuolization Cytoplasmic, Multifocal 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Bile Duct, Hyperplasia, Focal 1 (2%)
Bile Duct, Hyperplasia, Multifocal 1 (6%)
Centrilobular, Necrosis, Diffuse 1 (2%) 1 (6%)
Centrilobular, Necrosis, Multifocal 1 (2%)
Portal, Inflammation, Chronic 1 (6%)
Mesentery (8) (3) (2)
Infiltration Cellular, Multifocal, Lymphocyte 2 (25%)
Infiltration Cellular, Mixed Cell 2 (25%)
Fat, Necrosis, Focal 1 (33%)
Fat, Necrosis, Multifocal 2 (67%)
Pancreas (47) (3) (49)
Cytomegaly, Multifocal 2 (4%)
Hypertrophy, Focal 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 1 (2%) 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 9 (19%) 4 (8%)
Infiltration Cellular, Multifocal, Mixed Cell 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Acinus, Atrophy 3 (6%) 2 (4%)
Pharynx (1)
Palate, Ulcer, Chronic 1 (100%)
Salivary Glands (48) (1) (48)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 32 (67%) 21 (44%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Chronic Active, Focal 1 (2%)
Stomach, Forestomach (47) (3) (45)
Hyperplasia, Diffuse, Squamous 1 (2%)
Inflammation, Chronic Active, Focal 1 (2%)
Stomach, Glandular (47) (3) (47)
Developmental Malformation 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Inflammation, Chronic Active, Focal 1 (2%)
Tooth (1) (1)
Developmental Malformation 1 (100%)
Pulp, Inflammation, Chronic Active, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (48) (2) (48)
Bacterium 1 (2%)
Cardiomyopathy 2 (4%)
Inflammation, Chronic Active, Multifocal 1 (2%)
Aortic Valve, Thrombosis 1 (2%)
Atrium Left, Thrombosis 1 (2%) 1 (2%)
Mitral Valve, Inflammation, Chronic Active,
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Focal 1 (2%)
Pericardium, Infiltration Cellular,
Multifocal, Mixed Cell 1 (2%)
Valve, Pigmentation, Hemosiderin, Multifocal 1 (2%)
Ventricle, Mineralization, Focal 1 (2%)
Ventricle, Necrosis, Focal, Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (47) (3) (49)
Adrenal Gland, Accessory Adrenal Cortical
Nodule 2 (4%)
Capsule, Hyperplasia, Diffuse 13 (28%) 1 (33%) 12 (24%)
Capsule, Hyperplasia, Multifocal 33 (70%) 1 (33%) 32 (65%)
Capsule, Inflammation, Chronic Active, Focal 1 (2%)
Adrenal Gland, Cortex (47) (2) (48)
Accessory Adrenal Cortical Nodule 4 (9%) 2 (4%)
Angiectasis, Multifocal 1 (2%)
Atrophy, Focal 1 (2%)
Degeneration, Fatty, Focal 2 (4%)
Hyperplasia, Focal 1 (2%) 2 (4%)
Hypertrophy, Focal 1 (2%) 1 (2%)
Medulla, Hematopoietic Cell Proliferation,
Multifocal 1 (2%)
Adrenal Gland, Medulla (45) (2) (47)
Amyloid Deposition 1 (2%)
Hyperplasia, Focal 2 (4%) 1 (2%)
Islets, Pancreatic (47) (3) (49)
Atrophy, Multifocal 1 (2%) 1 (2%)
Hyperplasia, Multifocal 7 (15%) 1 (33%) 3 (6%)
Parathyroid Gland (29) (1) (25)
Infiltration Cellular, Focal, Lymphocyte 1 (3%) 2 (8%)
Pituitary Gland (46) (5) (47)
Pars Distalis, Angiectasis, Focal 7 (15%)
Pars Distalis, Hyperplasia, Focal 4 (9%)
Pars Distalis, Hyperplasia, Multifocal 1 (2%)
Pars Distalis, Hypertrophy, Focal 1 (2%)
Thyroid Gland (48) (2) (42)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Inflammation, Chronic Active, Focal 1 (2%)
Follicle, Cyst 1 (2%) 2 (5%)
Follicular Cell, Hyperplasia, Focal 1 (2%)
Follicular Cell, Hyperplasia, Multifocal 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1) (1)
Cyst, Multifocal 1 (100%)
Ovary (46) (14) (44)
Abscess, Multiple 1 (2%) 1 (7%)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Cyst 9 (20%) 9 (64%) 4 (9%)
Hemorrhage, Focal 2 (4%)
Hyperplasia, Diffuse 1 (2%)
Infiltration Cellular, Lymphocyte 2 (4%) 1 (7%)
Thrombosis 1 (2%)
Periovarian Tissue, Infiltration Cellular,
Lymphocyte 4 (9%)
Uterus (48) (37) (45)
Abscess, Single 1 (2%)
Adenomyosis 1 (2%)
Angiectasis 1 (2%)
Dilatation 2 (4%) 5 (14%) 12 (27%)
Hemorrhage, Acute 1 (2%)
Hyperplasia, Cystic 36 (75%) 29 (78%) 29 (64%)
Inflammation, Chronic, Diffuse 1 (2%)
Inflammation, Chronic Active, Multifocal 1 (2%)
Metaplasia, Squamous 1 (2%)
Thrombosis 1 (2%)
Serosa, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (47) (2) (47)
Hypoplasia, Focal 1 (2%)
Myeloid Cell, Hyperplasia 1 (2%)
Lymph Node (48) (8) (49)
Hyperplasia, Lymphoid 1 (2%)
Bronchial, Depletion Lymphoid, Diffuse 1 (2%)
Bronchial, Hyperplasia, Lymphoid 2 (4%)
Bronchial, Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Mediastinal, Hemorrhage 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 2 (4%)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Mandibular (45) (1) (43)
Hyperplasia, Lymphoid 4 (9%) 3 (7%)
Hyperplasia, Plasma Cell 3 (7%)
Hyperplasia, Re Cell 1 (2%) 1 (2%)
Infiltration Cellular, Diffuse,
Polymorphonuclear 1 (2%)
Pigmentation, Diffuse, Hemosiderin 1 (2%) 2 (5%)
Lymph Node, Mesenteric (38) (6) (32)
Hematopoietic Cell Proliferation 2 (33%)
Hemorrhage 3 (8%) 3 (50%)
Hyperplasia, Lymphoid 4 (11%)
Hyperplasia, Plasma Cell 1 (3%)
Hyperplasia, Re Cell 1 (3%)
Spleen (47) (13) (49)
Angiectasis 1 (2%)
Congestion 1 (2%)
Depletion Lymphoid 2 (4%)
Developmental Malformation 1 (2%)
Hematopoietic Cell Proliferation 6 (13%) 6 (46%)
Hyperplasia, Lymphoid 6 (13%) 2 (4%)
Hyperplasia, Plasma Cell 1 (2%)
Infarct 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 3 (6%)
Capsule, Abscess, Chronic 1 (2%)
Capsule, Ectopic Tissue 1 (2%)
Capsule, Fibrosis, Focal 1 (2%)
Thymus (40) (2) (42)
Angiectasis, Multifocal 1 (2%)
Cyst, Multiple 1 (2%)
Depletion Lymphoid 3 (8%) 2 (5%)
Ectopic Parathyroid Gland 2 (5%) 2 (5%)
Hyperplasia, Lymphoid 1 (3%) 3 (7%)
Epithelial Cell, Hyperplasia 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (1) (44)
Ectasia, Multifocal 1 (2%) 1 (2%)
Hyperplasia, Diffuse 2 (4%)
Infiltration Cellular, Multifocal, Mixed Cell 1 (2%)
Inflammation, Chronic, Diffuse 1 (2%)
Inflammation, Chronic Active, Diffuse 1 (2%)
Skin (46) (20) (47)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Inflammation, Chronic, Diffuse 1 (2%)
Inflammation, Chronic Active, Diffuse 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Subcutaneous Tissue, Edema 1 (2%) 1 (5%)
Subcutaneous Tissue, Hemorrhage, Acute 1 (5%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (47) (12) (47)
Fibrous Osteodystrophy 7 (15%) 10 (83%) 8 (17%)
Joint, Inflammation, Chronic, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (48) (2) (49)
Hemorrhage, Acute, Focal 1 (2%)
Hydrocephalus 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Mineralization, Multifocal 29 (60%) 1 (50%) 16 (33%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (40) (1) (40)
Inflammation, Chronic 1 (3%)
Inflammation, Chronic Active 2 (5%)
Lung (48) (49) (49)
Crystals 4 (8%) 1 (2%)
Edema 1 (2%)
Infiltration Cellular, Diffuse, Histiocyte 2 (4%) 2 (4%)
Infiltration Cellular, Diffuse, Mixed Cell 1 (2%)
Infiltration Cellular, Focal, Histiocyte 1 (2%) 4 (8%)
Infiltration Cellular, Multifocal, Lymphocyte 9 (19%) 10 (20%) 7 (14%)
Infiltration Cellular, Multifocal, Histiocyte 6 (12%) 4 (8%)
Inflammation, Chronic Active, Focal 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 1 (2%) 1 (2%)
Alveolus, Inflammation, Chronic Active, Focal 1 (2%)
Alveolus, Inflammation, Chronic Active,
Multifocal 1 (2%) 1 (2%)
Artery, Inflammation, Acute, Multifocal 1 (2%)
Bronchiole, Hyperplasia, Focal 1 (2%)
Bronchiole, Hyperplasia, Multifocal 1 (2%)
Bronchiole, Inflammation, Chronic Active,
Focal 1 (2%)
Bronchiole, Alveolus, Inflammation, Chronic
Active, Focal 5 (10%) 1 (2%)
Bronchiole, Alveolus, Inflammation, Chronic
Active, Multifocal 9 (18%) 35 (71%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Mediastinum, Infiltration Cellular,
Multifocal, Lymphocyte 2 (4%)
Peribronchiolar, Inflammation, Chronic
Active, Multifocal 1 (2%)
Pleura, Inflammation, Chronic Active,
Multifocal 1 (2%)
Nose (48) (49) (48)
Exudate 2 (4%)
Foreign Body 1 (2%)
Lumen, Crystals 3 (6%)
Mucosa, Inflammation, Chronic 1 (2%)
Mucosa, Inflammation, Chronic Active 3 (6%) 49 (100%) 47 (98%)
Nasolacrimal Duct, Hyperplasia 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic 3 (6%) 2 (4%)
Olfactory Epithelium, Atrophy, Focal 1 (2%)
Respiratory Epithelium, Hyperplasia 5 (10%) 49 (100%) 47 (98%)
Trachea (48) (2) (47)
Edema 1 (2%)
Inflammation, Chronic 1 (2%)
Metaplasia, Multifocal, Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2)
Atrophy 1 (50%)
Cornea, Neovascularization 1 (50%)
Lacrimal Gland (10) (5)
Infiltration Cellular, Focal, Lymphocyte 1 (10%) 2 (40%)
Infiltration Cellular, Multifocal, Lymphocyte 6 (60%) 2 (40%)
Infiltration Cellular, Multifocal, Mixed Cell 1 (10%)
Infiltration Cellular, Lymphocyte 1 (10%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (48) (7) (49)
Cyst 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 22 (46%) 7 (14%)
Capsule, Inflammation, Chronic Active 2 (4%)
Cortex, Regeneration, Multifocal 2 (4%)
Cortex, Epithelium, Hyperplasia, Atypical,
Multifocal 1 (2%)
Medulla, Epithelium, Karyomegaly, Multifocal 1 (2%)
Urinary Bladder (45) (2) (40)
Infiltration Cellular, Focal, Lymphocyte 2 (4%) 3 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Infiltration Cellular, Multifocal, Lymphocyte 19 (42%) 9 (23%)
Infiltration Cellular, Multifocal, Mixed Cell 1 (2%) 1 (3%)
Perforation 1 (3%)
Serosa, Inflammation, Chronic 1 (2%) 2 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund Sacrifice 10 13 4
Natural Death 6 7 2
Accidently Killed 1 1
Dosing Accident 2
Survivors
Terminal Sacrifice 33 30 41
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (9) (48)
Inflammation, Chronic Active 1 (2%) 1 (11%)
Gallbladder (41) (10) (37)
Epithelium, Hyperplasia 1 (2%)
Intestine Large, Cecum (46) (7) (44)
Hyperplasia, Focal, Lymphoid 1 (2%)
Mucosa, Necrosis, Acute 1 (2%)
Liver (50) (23) (48)
Angiectasis, Multifocal 1 (2%)
Anisokaryosis 1 (2%)
Basophilic Focus 2 (4%)
Basophilic Focus, Multiple 1 (2%)
Cyst Multilocular 2 (4%) 1 (2%)
Cytomegaly, Focal 1 (2%)
Degeneration, Ballooning, Multifocal 1 (2%)
Fatty Change, Focal 1 (2%) 1 (2%)
Fibrosis, Focal 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 1 (2%) 1 (4%)
Hepatodiaphragmatic Nodule 1 (2%)
Infarct, Single 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Infiltration Cellular, Multifocal, Histiocyte 1 (2%)
Inflammation, Acute, Multifocal 1 (2%)
Karyomegaly, Multifocal 1 (2%)
Necrosis, Acute, Focal 3 (13%) 1 (2%)
Necrosis, Acute, Multifocal 2 (4%) 2 (9%) 2 (4%)
Necrosis, Multifocal, Subacute 1 (2%)
Syncytial Alteration, Focal 1 (2%)
Syncytial Alteration, Multifocal 1 (2%)
Median Lobe, Congestion, Diffuse 1 (2%)
Median Lobe, Fibrosis 1 (2%)
Median Lobe, Thrombosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Median Lobe, Hepatocyte, Atrophy, Diffuse 1 (2%)
Mesentery (6) (3)
Infiltration Cellular, Multifocal, Lymphocyte 2 (33%) 1 (33%)
Inflammation, Acute, Focal 1 (17%)
Artery, Adventitia, Infiltration Cellular,
Focal, Mixed Cell 1 (17%)
Fat, Inflammation, Chronic Active, Focal 1 (33%)
Pancreas (49) (9) (49)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%) 2 (4%)
Acinus, Atrophy, Multifocal 1 (2%)
Acinus, Hyperplasia, Focal 1 (2%)
Acinus, Hypertrophy, Focal 1 (2%)
Acinus, Hypertrophy, Multifocal 1 (2%)
Artery, Inflammation, Chronic Active, Focal 1 (2%)
Salivary Glands (50) (11) (50)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 24 (48%) 2 (18%) 24 (48%)
Stomach, Forestomach (48) (10) (47)
Hyperplasia, Focal, Squamous 1 (2%)
Epithelium, Hyperplasia, Focal 1 (2%) 1 (2%)
Stomach, Glandular (47) (11) (49)
Inflammation, Chronic Active, Focal 1 (2%)
Inflammation, Chronic Active, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (13) (50)
Cardiomyopathy 1 (8%) 1 (2%)
Artery, Embolus, Single 1 (2%)
Artery, Inflammation, Chronic Active 1 (8%)
Coronary Artery, Infiltration Cellular,
Focal, Mixed Cell 1 (2%)
Mitral Valve, Pigmentation, Focal,
Hemosiderin 1 (2%)
Myocardium, Inflammation, Chronic Active,
Multifocal 1 (2%)
Perivascular, Inflammation, Acute, Focal 1 (2%)
Ventricle, Karyomegaly, Multifocal 1 (2%)
Ventricle Left, Bacterium 1 (2%)
Ventricle Left, Inflammation, Focal, Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (10) (48)
Capsule, Hyperplasia, Focal 3 (6%) 2 (4%)
Capsule, Hyperplasia, Multifocal 36 (73%) 3 (30%) 39 (81%)
Adrenal Gland, Cortex (49) (10) (48)
Accessory Adrenal Cortical Nodule 1 (2%) 3 (6%)
Hyperplasia, Focal 5 (10%) 7 (15%)
Hyperplasia, Multifocal 6 (12%) 5 (10%)
Hypertrophy, Focal 7 (14%) 1 (10%) 8 (17%)
Hypertrophy, Multifocal 6 (12%) 3 (6%)
Adrenal Gland, Medulla (49) (9) (47)
Hyperplasia, Focal 1 (2%)
Islets, Pancreatic (49) (9) (49)
Hyperplasia, Focal 2 (4%)
Hyperplasia, Multifocal 7 (14%) 1 (11%) 4 (8%)
Parathyroid Gland (36) (6) (35)
Infiltration Cellular, Focal, Lymphocyte 1 (3%)
Pituitary Gland (45) (11) (47)
Pars Distalis, Cyst 2 (4%) 2 (4%)
Thyroid Gland (49) (9) (47)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Ultimobranchial Cyst 1 (2%) 2 (4%)
Follicular Cell, Hyperplasia 1 (2%)
Follicular Cell, Hyperplasia, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Inflammation, Chronic Active, Multifocal 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1)
Inflammation, Chronic Active 1 (100%)
Preputial Gland (15) (6) (8)
Abscess 6 (40%) 1 (17%)
Cyst 5 (33%) 1 (17%) 8 (100%)
Cyst Multilocular 1 (7%)
Dilatation 1 (17%)
Inflammation, Chronic 3 (20%) 3 (50%)
Inflammation, Chronic Active 7 (47%)
Prostate (46) (9) (44)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Inflammation, Acute, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic Active 3 (7%) 1 (11%)
Seminal Vesicle (48) (17) (49)
Dilatation 1 (2%) 1 (6%)
Testes (50) (12) (49)
Left, Hemorrhage 1 (2%)
Seminiferous Tubule, Atrophy 3 (6%) 1 (8%) 3 (6%)
Seminiferous Tubule, Degeneration, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (10) (49)
Myeloid Cell, Hyperplasia 5 (10%) 2 (20%)
Lymph Node (50) (26) (50)
Angiectasis, Focal 1 (4%)
Bronchial, Hemorrhage 1 (2%)
Inguinal, Hyperplasia, Lymphoid 1 (4%)
Inguinal, Hyperplasia, Re Cell 1 (2%)
Lumbar, Hemorrhage 1 (2%)
Lumbar, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (4%) 1 (2%)
Lymph Node, Mandibular (47) (11) (35)
Hyperplasia, Lymphoid 2 (6%)
Hyperplasia, Re Cell 3 (6%) 3 (9%)
Lymph Node, Mesenteric (42) (19) (33)
Hematopoietic Cell Proliferation 6 (14%) 4 (21%)
Hemorrhage 25 (60%) 12 (63%) 14 (42%)
Hyperplasia 1 (5%)
Hyperplasia, Lymphoid 1 (5%) 2 (6%)
Hyperplasia, Re Cell 2 (5%) 3 (9%)
Spleen (49) (14) (49)
Angiectasis, Multifocal 1 (2%)
Depletion Lymphoid 1 (2%)
Hematopoietic Cell Proliferation 11 (22%) 6 (43%) 2 (4%)
Hyperplasia, Diffuse, Lymphoid 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
Hyperplasia, Re Cell 1 (2%)
Thrombosis 1 (2%)
Lymphocyte, Necrosis, Multifocal 1 (2%)
Thymus (35) (6) (34)
Cyst, Multiple 1 (3%)
Depletion Lymphoid 1 (3%) 1 (17%) 1 (3%)
Hyperplasia, Diffuse, Lymphoid 1 (3%)
Inflammation, Acute 1 (17%)
Syncytial Alteration 1 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (30) (49)
Inflammation, Chronic Active 1 (2%) 1 (3%) 1 (2%)
Ulcer 1 (3%)
Prepuce, Abscess 2 (7%)
Prepuce, Inflammation, Chronic Active 1 (3%)
Prepuce, Necrosis 3 (6%)
Prepuce, Ulcer 2 (4%) 2 (7%)
Scrotal, Pigmentation, Focal, Melanin 1 (3%)
Scrotal, Hair Follicle, Hyperplasia, Focal 1 (3%)
Subcutaneous Tissue, Abscess 1 (3%)
Subcutaneous Tissue, Cyst 1 (2%)
Subcutaneous Tissue, Edema 1 (3%)
Subcutaneous Tissue, Inflammation, Focal,
Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (10) (50)
Hyperostosis 1 (2%)
Osteoporosis, Focal 1 (2%)
Sternum, Developmental Malformation 1 (2%)
Skeletal Muscle (1) (1)
Arteriole, Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (11) (50)
Hydrocephalus 1 (2%)
Mineralization, Focal 1 (2%)
Mineralization, Multifocal 26 (52%) 5 (45%) 21 (42%)
Artery, Meninges, Inflammation, Chronic,
Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (44) (6) (46)
Inflammation, Acute, Diffuse 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Chronic, Multifocal 1 (2%)
Lung (50) (49) (49)
Congestion 1 (2%) 1 (2%)
Granuloma 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Infiltration Cellular, Diffuse, Histiocyte 1 (2%)
Infiltration Cellular, Focal, Histiocyte 2 (4%) 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 5 (10%) 1 (2%) 3 (6%)
Infiltration Cellular, Multifocal, Histiocyte 3 (6%) 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 2 (4%) 2 (4%)
Alveolus, Infiltration Cellular, Multifocal,
Histiocyte 1 (2%)
Alveolus, Inflammation, Chronic Active, Focal 1 (2%) 1 (2%)
Alveolus, Inflammation, Chronic Active,
Multifocal 3 (6%)
Bronchiole, Hyperplasia, Focal 1 (2%)
Bronchiole, Hyperplasia, Multifocal 4 (8%)
Bronchiole, Inflammation, Chronic, Focal 1 (2%)
Bronchiole, Alveolus, Inflammation, Chronic,
Multifocal 1 (2%)
Bronchiole, Alveolus, Inflammation, Chronic
Active, Focal 3 (6%) 1 (2%)
Bronchiole, Alveolus, Inflammation, Chronic
Active, Multifocal 12 (24%) 29 (59%)
Interstitium, Inflammation, Acute, Focal 1 (2%)
Mediastinum, Infiltration Cellular,
Multifocal, Lymphocyte 1 (2%) 2 (4%)
Pleura, Hyperplasia, Diffuse 1 (2%)
Pleura, Infiltration Cellular, Lymphocyte 1 (2%)
Nose (50) (48) (49)
Mucosa, Inflammation, Acute 3 (6%) 1 (2%)
Mucosa, Inflammation, Chronic 1 (2%)
Mucosa, Inflammation, Chronic Active 2 (4%) 47 (98%) 48 (98%)
Nasolacrimal Duct, Inflammation, Chronic 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic
Active 1 (2%)
Respiratory Epithelium, Hyperplasia 5 (10%) 48 (100%) 49 (100%)
Trachea (49) (9) (48)
Inflammation, Chronic, Focal 1 (2%)
Glands, Hyperplasia, Diffuse 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cornea, Left, Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 25 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (11) (50)
Congestion 1 (2%)
Cyst, Single 1 (2%)
Degeneration, Chronic, Focal, Two 1 (2%)
Degeneration, Chronic, Multifocal 1 (2%)
Embolus, Multifocal 1 (2%)
Hydronephrosis 3 (6%) 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 1 (2%) 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 9 (18%) 3 (6%)
Infiltration Cellular, Multifocal, Mixed Cell 1 (2%)
Inflammation, Acute, Focal 1 (9%)
Inflammation, Acute, Multifocal, Suppurative 1 (2%)
Inflammation, Chronic Active, Multifocal,
Suppurative 2 (4%) 1 (9%)
Mineralization, Focal 1 (2%)
Mineralization, Multifocal 1 (9%)
Nephropathy, Chronic 1 (9%) 3 (6%)
Artery, Inflammation 1 (2%)
Capsule, Fibrosis, Multifocal 1 (9%)
Cortex, Renal Tubule, Epithelium,
Hyperplasia, Atypical, Focal 1 (2%)
Urethra (1)
Calculus Micro Observation Only 1 (100%)
Urinary Bladder (49) (27) (47)
Calculus Micro Observation Only 2 (4%)
Embolus 1 (2%)
Inflammation, Chronic Active, Diffuse 1 (2%) 1 (4%)
Inflammation, Chronic Active, Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
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