National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1625

TDMS Study 05070-02 Pathology Tables

NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27




       Facility:  Midwest Research Institute

       Chemical CAS #:  25013154

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|             
                                           | 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +  +  +     A  +  +|             
      Dilatation                           |          4                                                               |             
      Infiltration Cellular, Lymphocyte    |                            1                                             |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  M  +  +     +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                 4                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Serosa, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                       2                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +  +  +     A  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +        +  +|             
      Serosa, Ileum, Jejunum, Inflammation,|                                                                          |             
           Chronic Active, Multifocal      |                                                       2                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +     +  +  +     +  +  +  +     +  +        +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |                                                                   1      |             
      Granuloma, Multifocal                |                         1                                                |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |          4                                            4                  |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Infarct                              |                                                 4                        |             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                            1                                             |             
      Infiltration Cellular, Mixed Cell    |                                                                      2   |             
      Inflammation, Multifocal, Subacute   | 1  1                                                                    1|             
      Necrosis, Multifocal                 |                                                 2                        |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Multifocal|                      2                                                   |             
      Bile Duct, Hyperplasia, Focal        |                               1                                          |             
      Centrilobular, Necrosis, Diffuse     |       3                                                                  |             
      Centrilobular, Necrosis, Multifocal  |                                                    3                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                       +        +     +                 +      |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                  3        1                              |             
      Infiltration Cellular, Mixed Cell    |                                                 2                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Cytomegaly, Multifocal               |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|             
                                           | 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                              2           3               |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Mixed Cell                      |                                                                          |             
      Inflammation, Chronic Active         |                3                                      2                  |             
      Acinus, Atrophy                      |          3              4                                                |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Ulcer, Chronic               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                      2                                                   |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2  2     2  1                 3  2           3  2        4  1        2  3|             
      Inflammation, Chronic Active, Focal  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic Active, Focal  |                                                                      2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Developmental Malformation           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Pulp, Inflammation, Chronic Active,  |                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Bacterium                            |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Aortic Valve, Thrombosis             |                                                                         2|             
      Atrium Left, Thrombosis              |                                                                          |             
      Mitral Valve, Inflammation, Chronic  |                                                                          |             
          Active, Focal                    |                                                       3                  |             
      Pericardium, Infiltration Cellular,  |                                                                          |             
           Multifocal, Mixed Cell          |                                                                          |             
      Valve, Pigmentation, Hemosiderin,    |                                                                          |             
           Multifocal                      |                            2                                             |             
      Ventricle, Mineralization, Focal     |                                                                          |             
      Ventricle, Necrosis, Focal, Subacute |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|             
                                           | 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Adrenal Gland, Accessory Adrenal     |                                                                          |             
          Cortical Nodule                  |                                                                          |             
      Capsule, Hyperplasia, Diffuse        | 3           4                             3     2                        |             
      Capsule, Hyperplasia, Multifocal     |    2  2  3     4     4  2  3  2  4  2        4     2  2  3  3     2  2  2|             
      Capsule, Inflammation, Chronic       |                                                                          |             
          Active, Focal                    |                                                       3                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                              X     X                     |             
      Degeneration, Fatty, Focal           |                               3                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Medulla, Hematopoietic Cell          |                                                                          |             
          Proliferation, Multifocal        |                                                       4                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Atrophy, Multifocal                  |                         3                                                |             
      Hyperplasia, Multifocal              |                                                                   2      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  M  M  M  +  M  M  +     M  M  +  M  +  +  +     M  +  M|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  M  +  +  +  +     +  +  +|             
      Pars Distalis, Angiectasis, Focal    | 3        2                       2                                       |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Pars Distalis, Hypertrophy, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                         1|             
      Inflammation, Chronic Active, Focal  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                      2                                                   |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Abscess, Multiple                    |                                                       4                  |             
      Atrophy                              |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|             
                                           | 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 | 2           X        2     4                                             |             
      Hemorrhage, Focal                    |    3                                               4                     |             
      Infiltration Cellular, Lymphocyte    |             2                                                            |             
      Thrombosis                           |                                                 4                        |             
      Periovarian Tissue, Infiltration     |                                                                          |             
          Cellular, Lymphocyte             |                                              2                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Abscess, Single                      |                                                       3                  |             
      Adenomyosis                          |             2                                                            |             
      Angiectasis                          |                      4                                                   |             
      Dilatation                           |    3                 3                                                   |             
      Hemorrhage, Acute                    |                   4                                                      |             
      Hyperplasia, Cystic                  | 3           4  2  3        2  3  1        3  3  2     3  1  1     2  1  2|             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Thrombosis                           |                                                                          |             
      Serosa, Cyst                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Bronchial, Depletion Lymphoid,       |                                                                          |             
          Diffuse                          |                                                                          |             
      Bronchial, Hyperplasia, Plasma Cell  |                                                                          |             
      Mediastinal, Hemorrhage              |                                     3                                    |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia, Lymphoid                |                                              2  2                        |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Hyperplasia, Re Cell                 |                         3                                                |             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Polymorphonuclear                |                                                       3                  |             
      Pigmentation, Diffuse, Hemosiderin   |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  M  +  +  +  +  M     +  +  +  +  +  +  +     M  +  +|             
      Hemorrhage                           |                                              2                           |             
      Hyperplasia, Lymphoid                |                            2  2                                          |             
      Hyperplasia, Plasma Cell             |                                                       4                  |             
      Hyperplasia, Re Cell                 |                                                    3                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Angiectasis                          |                               2                                          |             
      Hematopoietic Cell Proliferation     |          4                                         3  4              2   |             
      Hyperplasia, Lymphoid                |                                           2                 4            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|             
                                           | 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infarct                              |                                                                          |             
      Pigmentation, Hemosiderin            |                         2           2                                    |             
      Capsule, Abscess, Chronic            |                                                       4                  |             
      Capsule, Ectopic Tissue              |                                                                          |             
      Capsule, Fibrosis, Focal             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  M  +  +  +  +  +  +  +     +  +  +  +  M  M  M     +  M  +|             
      Depletion Lymphoid                   |          3                          4                                    |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Hyperplasia, Lymphoid                |                                           2                              |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Ectasia, Multifocal                  |                                                                          |             
      Hyperplasia, Diffuse                 |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Mixed Cell                      |                                                                          |             
      Inflammation, Chronic, Diffuse       |                                                       3                  |             
      Inflammation, Chronic Active, Diffuse|                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       | 2                                                                        |             
      Inflammation, Chronic, Diffuse       |                2                                                         |             
      Inflammation, Chronic Active, Diffuse|                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Fibrous Osteodystrophy               |                      2        3  2                                       |             
      Joint, Inflammation, Chronic, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Hemorrhage, Acute, Focal             |                                     2                                    |             
      Hydrocephalus                        |                                     2                                    |             
      Inflammation, Acute, Focal           |                                                                          |             
      Mineralization, Multifocal           | 2  1     2  1        2     2  2           2  2           2  1           3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     M  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Infiltration Cellular, Diffuse,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|             
                                           | 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Histiocyte                       |                   1                 3                                    |             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Mixed Cell                       |                                                       3                  |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2                    2     2  2  2                                       |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Artery, Inflammation, Acute,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Multifocal, Lymphocyte          |                                                             3            |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active, Multifocal       |          1                                                               |             
      Pleura, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                       3                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Foreign Body                         |                2                                                         |             
      Mucosa, Inflammation, Chronic        | 1                                                                        |             
      Mucosa, Inflammation, Chronic Active |                2                                                     1   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                         1                                                |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                2     2                                                   |             
      Olfactory Epithelium, Atrophy, Focal |                                              3                           |             
      Respiratory Epithelium, Hyperplasia  | 1              1                                                     1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic                |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
      Atrophy                              |                                                                          |             
      Cornea, Neovascularization           |                3                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |       +                    +  +              +  +                    +   |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                            2                                             |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                              2  4                    2   |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Mixed Cell                      |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|             
                                           | 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Cyst                                 |                      4                                                   |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 1           2        2        3              2           2  2        1  3|             
      Capsule, Inflammation, Chronic Active|                                                 3     2                  |             
      Medulla, Epithelium, Karyomegaly,    |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2  1        1              1  3  4              2        1               |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Mixed Cell                      |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3|            |
                                           | 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +  +  +  +  M  +  +  +  +  M  +  +  M  +  M  +  M  M  +  +  +|  38        |
      Dilatation                           |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                                           2                              |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Serosa, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                2        4|      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Serosa, Ileum, Jejunum, Inflammation,|                                                                          |            |
           Chronic Active, Multifocal      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  42        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Eosinophilic Focus                   |                                                                X         |      1     |
      Fatty Change, Diffuse                |                                                                          |      1  1.0|
      Granuloma, Multifocal                |                                                                1         |      2  1.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                2                                                         |      3  3.3|
      Hepatodiaphragmatic Nodule           |                                                                      X   |      1     |
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Lymphocyte                       |                   3                                                      |      1  3.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |       1                 1                          1                    1|      5  1.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Inflammation, Multifocal, Subacute   | 1  1                                1     1     1                        |      8  1.0|
      Necrosis, Multifocal                 |                                                          4               |      2  3.0|
      Vacuolization Cytoplasmic, Diffuse   |                                              2                           |      1  2.0|
      Vacuolization Cytoplasmic, Multifocal|                                                                          |      1  2.0|
      Bile Duct, Hyperplasia, Focal        |                                                                          |      1  1.0|
      Centrilobular, Necrosis, Diffuse     |                                                                          |      1  3.0|
      Centrilobular, Necrosis, Multifocal  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                    +  +            |   8        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3|            |
                                           | 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      2  2.0|
      Infiltration Cellular, Mixed Cell    |                                     3                                    |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cytomegaly, Multifocal               |          2                                                               |      2  2.0|
      Hypertrophy, Focal                   |          2                                                               |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |          2                                                               |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      | 2                 2  2              4     3     2              2         |      9  2.4|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Mixed Cell                      |                                        3                                 |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Acinus, Atrophy                      |                                        4                                 |      3  3.7|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                +         |   1        |
      Palate, Ulcer, Chronic               |                                                                4         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      | 3  2  1  4  3     3  4  3     3     2  2  4  2  2     2  1     2  2  3  2|     32  2.4|
      Inflammation, Chronic Active, Focal  |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic Active, Focal  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Developmental Malformation           |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   1        |
      Pulp, Inflammation, Chronic Active,  |                                                                          |            |
           Focal                           |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Bacterium                            |                4                                                         |      1  4.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                4                                                         |      1  4.0|
      Aortic Valve, Thrombosis             |                                                                          |      1  2.0|
      Atrium Left, Thrombosis              |                4                                                         |      1  4.0|
      Mitral Valve, Inflammation, Chronic  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3|            |
                                           | 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
          Active, Focal                    |                                                                          |      1  3.0|
      Pericardium, Infiltration Cellular,  |                                                                          |            |
           Multifocal, Mixed Cell          |                               2                                          |      1  2.0|
      Valve, Pigmentation, Hemosiderin,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Ventricle, Mineralization, Focal     |                                                    2                     |      1  2.0|
      Ventricle, Necrosis, Focal, Subacute |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
      Adrenal Gland, Accessory Adrenal     |                                                                          |            |
          Cortical Nodule                  |                                           X                    X         |      2     |
      Capsule, Hyperplasia, Diffuse        |    2     2                 4     3  3  3        3     3              3   |     13  2.9|
      Capsule, Hyperplasia, Multifocal     | 2     2     2  3  3  3  3     3           3  3     2     3  2  2  2      |     33  2.6|
      Capsule, Inflammation, Chronic       |                                                                          |            |
          Active, Focal                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Accessory Adrenal Cortical Nodule    |                               X                          X               |      4     |
      Degeneration, Fatty, Focal           |             3                                                            |      2  3.0|
      Hyperplasia, Focal                   |                                        3                                 |      1  3.0|
      Hypertrophy, Focal                   |                                                             2            |      1  2.0|
      Medulla, Hematopoietic Cell          |                                                                          |            |
          Proliferation, Multifocal        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +   |  45        |
      Hyperplasia, Focal                   |    2                                               2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy, Multifocal                  |                                                                          |      1  3.0|
      Hyperplasia, Multifocal              |                      3              3           3              2  2  2   |      7  2.4|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  M  +  M  +  +  M  +  M  M  M  +  +  +  +  +  M  +|  29        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Pars Distalis, Angiectasis, Focal    |          2                 2           3                       2         |      7  2.3|
      Pars Distalis, Hyperplasia, Focal    |          1  2                    4        3                              |      4  2.5|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                                     2                                    |      1  2.0|
      Pars Distalis, Hypertrophy, Focal    |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Infiltration Cellular, Focal,        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3|            |
                                           | 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  1.0|
      Inflammation, Chronic Active, Focal  |                                                                1         |      1  1.0|
      Follicle, Cyst                       |                                                             2            |      1  2.0|
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                            2                    1                        |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  46        |
      Abscess, Multiple                    |                                                                          |      1  4.0|
      Atrophy                              |                                                                          |      1  4.0|
      Cyst                                 |    3                                   X     3     X           X         |      9  2.8|
      Hemorrhage, Focal                    |                                                                          |      2  3.5|
      Infiltration Cellular, Lymphocyte    |                                                    2                     |      2  2.0|
      Thrombosis                           |                                                                          |      1  4.0|
      Periovarian Tissue, Infiltration     |                                                                          |            |
          Cellular, Lymphocyte             |                         4           3                          2         |      4  2.8|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Abscess, Single                      |                                                                          |      1  3.0|
      Adenomyosis                          |                                                                          |      1  2.0|
      Angiectasis                          |                                                                          |      1  4.0|
      Dilatation                           |                                                                          |      2  3.0|
      Hemorrhage, Acute                    |                                                                          |      1  4.0|
      Hyperplasia, Cystic                  | 2  2  3  2  3  3     3  4  4  4  3  3  3  3     3           2  1  2  1  3|     36  2.5|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                3                                                         |      1  3.0|
      Thrombosis                           |             X                                                            |      1     |
      Serosa, Cyst                         |                                                    X                     |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Myeloid Cell, Hyperplasia            |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                                        3                                 |      1  3.0|
      Bronchial, Depletion Lymphoid,       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3|            |
                                           | 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Diffuse                          |                                  3                                       |      1  3.0|
      Bronchial, Hyperplasia, Plasma Cell  |                                     3                                    |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia, Lymphoid                |       4                                                        4         |      4  3.0|
      Hyperplasia, Plasma Cell             |                                     2     3        2                     |      3  2.3|
      Hyperplasia, Re Cell                 |                                                                          |      1  3.0|
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  3.0|
      Pigmentation, Diffuse, Hemosiderin   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  M  I  +  +  +  +  +  +  +  +  M  +  M  +  M  +|  38        |
      Hemorrhage                           |       3              2                                                   |      3  2.3|
      Hyperplasia, Lymphoid                |                                  3  3                                    |      4  2.5|
      Hyperplasia, Plasma Cell             |                                                                          |      1  4.0|
      Hyperplasia, Re Cell                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                3                                                  4      |      6  3.3|
      Hyperplasia, Lymphoid                |       3        2  4                                      3               |      6  3.0|
      Infarct                              |                                                             4            |      1  4.0|
      Pigmentation, Hemosiderin            |                                                                2         |      3  2.0|
      Capsule, Abscess, Chronic            |                                                                          |      1  4.0|
      Capsule, Ectopic Tissue              |    X                                                                     |      1     |
      Capsule, Fibrosis, Focal             |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  40        |
      Depletion Lymphoid                   |          3                                                               |      3  3.3|
      Ectopic Parathyroid Gland            |                                                       X           X      |      2     |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Epithelial Cell, Hyperplasia         |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Ectasia, Multifocal                  |                                                    2                     |      1  2.0|
      Hyperplasia, Diffuse                 |       2                                                              3   |      2  2.5|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Mixed Cell                      |                               2                                          |      1  2.0|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  3.0|
      Inflammation, Chronic Active, Diffuse|                                                          2               |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3|            |
                                           | 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  2.0|
      Inflammation, Chronic Active, Diffuse|                      1                                                   |      1  1.0|
      Subcutaneous Tissue, Edema           |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Fibrous Osteodystrophy               |             3           3           3                                2   |      7  2.6|
      Joint, Inflammation, Chronic, Focal  |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage, Acute, Focal             |                                                                          |      1  2.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
      Inflammation, Acute, Focal           |                2                                                         |      1  2.0|
      Mineralization, Multifocal           |       3  2  3  2     1  2  2  3     2     2     2  3     2  1  1  3  2   |     29  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  M  M  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +|  40        |
      Inflammation, Chronic                |                                                                         2|      1  2.0|
      Inflammation, Chronic Active         |                                     2                    3               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Histiocyte                       |                                                                          |      2  2.0|
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Mixed Cell                       |                                                                          |      1  3.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       | 3                                                                        |      1  3.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                   2  1                    3     1                        |      9  1.9|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           | 3                                                                        |      1  3.0|
      Artery, Inflammation, Acute,         |                                                                          |            |
          Multifocal                       |                4                                                         |      1  4.0|
      Mediastinum, Infiltration Cellular,  |                                                                          |            |
           Multifocal, Lymphocyte          |                2                                                         |      2  2.5|
      Peribronchiolar, Inflammation,       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3|            |
                                           | 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Chronic Active, Multifocal       |                                                                          |      1  1.0|
      Pleura, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Foreign Body                         |                                                                          |      1  2.0|
      Mucosa, Inflammation, Chronic        |                                                                          |      1  1.0|
      Mucosa, Inflammation, Chronic Active |                            1                                             |      3  1.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                   2                                                      |      3  2.0|
      Olfactory Epithelium, Atrophy, Focal |                                                                          |      1  3.0|
      Respiratory Epithelium, Hyperplasia  |                            1           1                                 |      5  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                       +                  |   2        |
      Atrophy                              |                                                       4                  |      1  4.0|
      Cornea, Neovascularization           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                 +           +  +     +   |  10        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                 2           2  3         |      6  2.5|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Mixed Cell                      |                                                                      2   |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                                          |      1  4.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |       3  2  2     1  1        1        2  3  2     2           1  2     1|     22  1.9|
      Capsule, Inflammation, Chronic Active|                                                                          |      2  2.5|
      Medulla, Epithelium, Karyomegaly,    |                                                                          |            |
           Multifocal                      |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  45        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3|            |
                                           | 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                        1                       2         |      2  1.5|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      | 1     2  2  1  2  2     2           1     2        2                 2   |     19  1.8|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Mixed Cell                      |                               1                                          |      1  1.0|
      Serosa, Inflammation, Chronic        |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 6| 0| 7| 1| 1| 1| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 2| 0| 4| 3| 4| 4| 4| 3|             
                                           | 5| 7| 5| 4| 4| 4| 3| 3| 3| 3| 3| 2| 6| 2| 1| 5| 5| 8| 3| 2| 4| 8| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    25 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  M  M  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  M  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +     +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +     +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  M  +  A  +  +  +  +     +  +  A  +  +  +  +  +  +     +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                                          |             
      Cytomegaly, Focal                    |                                                                          |             
      Fatty Change, Diffuse                |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                              1                           |             
      Hemorrhage, Multifocal               |                                           2                              |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                    2                     |             
      Inflammation, Multifocal, Subacute   | 1        1                       1  3     1                              |             
      Necrosis, Multifocal                 |                                                       1                  |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |          2                                                               |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                  1                                       |             
      Inflammation, Chronic Active         |                                                    3                     |             
      Acinus, Atrophy                      |    4                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia, Lymphoid                |                                  3                                       |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2        3     2  1  2  2              3  2                 2            |             
      Inflammation, Chronic, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +|             
      Hyperplasia, Diffuse, Squamous       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 6| 0| 7| 1| 1| 1| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 2| 0| 4| 3| 4| 4| 4| 3|             
                                           | 5| 7| 5| 4| 4| 4| 3| 3| 3| 3| 3| 2| 6| 2| 1| 5| 5| 8| 3| 2| 4| 8| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    25 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active, Focal  | 2                                                                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |                +                                                         |             
      Developmental Malformation           |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                     1                                    |             
      Atrium Left, Thrombosis              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia, Diffuse        |       3           4     2        4     4                                 |             
      Capsule, Hyperplasia, Multifocal     | 3        3  1  4     3        3     3     3  3  3  2        2  2  2  2  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                    X                     |             
      Angiectasis, Multifocal              |             3                                                            |             
      Atrophy, Focal                       |                                              2                           |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Amyloid Deposition                   |                                           2                              |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Multifocal                  |                                                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +  +  M  +  M  M  M  +  M  +  +  M  +  +  M  +  M  M  M  M|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|             
      Follicle, Cyst                       |       3                                                                  |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Cyst, Multifocal                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|             
      Angiectasis                          |                               1                                          |             
      Cyst                                 |                                                             X            |             
      Hyperplasia, Diffuse                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 6| 0| 7| 1| 1| 1| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 2| 0| 4| 3| 4| 4| 4| 3|             
                                           | 5| 7| 5| 4| 4| 4| 3| 3| 3| 3| 3| 2| 6| 2| 1| 5| 5| 8| 3| 2| 4| 8| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    25 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Dilatation                           |       4           4                                   3                  |             
      Hyperplasia, Cystic                  | 2     2  2     1     1  1     1  1     1     1  1           2  1        2|             
      Inflammation, Chronic, Diffuse       |                   3                                                      |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hypoplasia, Focal                    |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |             
      Bronchial, Hyperplasia, Plasma Cell  |             2                                                            |             
      Mediastinal, Hyperplasia, Lymphoid   |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +|             
      Hyperplasia, Lymphoid                |                   4  3                                                   |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Pigmentation, Diffuse, Hemosiderin   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  I  +  +     M  +  M  +  M  +  +  M  +  M  +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    3                     |             
      Depletion Lymphoid                   |                            3                             4               |             
      Developmental Malformation           |                                                                          |             
      Hyperplasia, Lymphoid                |                                        3     2                           |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Infarct                              |    4                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +|             
      Angiectasis, Multifocal              |                                                                          |             
      Cyst, Multiple                       |                                                                          |             
      Depletion Lymphoid                   |                                     3                                    |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Hyperplasia, Lymphoid                |          2                       2                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +|             
      Ectasia, Multifocal                  |             2                                                            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active, Diffuse|                   1  2                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Fibrous Osteodystrophy               |          2                    2                                         2|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 6| 0| 7| 1| 1| 1| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 2| 0| 4| 3| 4| 4| 4| 3|             
                                           | 5| 7| 5| 4| 4| 4| 3| 3| 3| 3| 3| 2| 6| 2| 1| 5| 5| 8| 3| 2| 4| 8| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    25 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization, Multifocal           |                2              1     1  2     1  2                       1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Crystals                             |                                           4                              |             
      Edema                                |                                                                          |             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Histiocyte                       |             4                                                            |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |          2           3                 2        3                        |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      |                   2                    1  3                              |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                              2                           |             
      Alveolus, Inflammation, Chronic      |                                                                          |             
          Active, Focal                    |                      2                                                   |             
      Alveolus, Inflammation, Chronic      |                                                                          |             
          Active, Multifocal               |                                                                          |             
      Bronchiole, Inflammation, Chronic    |                                                                          |             
          Active, Focal                    |                                                                          |             
      Bronchiole, Alveolus, Inflammation,  |                                                                          |             
           Chronic Active, Focal           |                                                                          |             
      Bronchiole, Alveolus, Inflammation,  |                                                                          |             
           Chronic Active, Multifocal      | 3  1  1  1  2  2        1     2  2  2     2  2  1  2        1           2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Lumen, Crystals                      |                                                                          |             
      Mucosa, Inflammation, Chronic Active | 3  1  3  3  2  2  4  2  2     3  4  3  2  2  2  3  2  3     3  1  3  3  4|             
      Nasolacrimal Duct, Hyperplasia       |             2                                                            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                             2            |             
      Respiratory Epithelium, Hyperplasia  | 4  4  4  4  4  4  4  4  4     4  4  4  4  4  4  4  4  4     4  4  4  4  4|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Edema                                |                                                                          |             
      Metaplasia, Multifocal, Squamous     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                        +                                +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                        2                                 |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 6| 0| 7| 1| 1| 1| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 2| 0| 4| 3| 4| 4| 4| 3|             
                                           | 5| 7| 5| 4| 4| 4| 3| 3| 3| 3| 3| 2| 6| 2| 1| 5| 5| 8| 3| 2| 4| 8| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    25 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                      2                 2                                 |             
      Cortex, Regeneration, Multifocal     |                                     2                                    |             
      Cortex, Epithelium, Hyperplasia,     |                                                                          |             
           Atypical, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  M  M  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                2                                                         |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                         1        1                                      1|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Mixed Cell                      |                                                                          |             
      Perforation                          |                                     X                                    |             
      Serosa, Inflammation, Chronic        |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 1| 1| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 4| 4| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 3| 2| 2| 1| 5| 4| 4| 0| 4| 4| 8| 8| 8| 2| 3| 3| 2| 2| 2| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +|  42        |
      Infiltration Cellular, Lymphocyte    | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +     +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +        +  M  M  M  +  +  +  +  +  +  +  +  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  M  +  +  +  +     +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Clear Cell Focus                     |    X                                                                     |      1     |
      Cytomegaly, Focal                    |    3                                                                     |      1  3.0|
      Fatty Change, Diffuse                |                                           2                              |      1  2.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      | 2                                                                 1     1|      3  1.3|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Inflammation, Multifocal, Subacute   |                                                                          |      5  1.4|
      Necrosis, Multifocal                 |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic, Multifocal|                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |       1                                                     2     2      |      4  1.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Acinus, Atrophy                      |                                           4                              |      2  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    2     2  2     1  2     1                          2  2  2  1  2  4   |     21  2.0|
      Inflammation, Chronic, Focal         |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 1| 1| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 4| 4| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 3| 2| 2| 1| 5| 4| 4| 0| 4| 4| 8| 8| 8| 2| 3| 3| 2| 2| 2| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia, Diffuse, Squamous       |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
      Inflammation, Chronic Active, Focal  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Developmental Malformation           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cardiomyopathy                       |                   2                                                      |      2  1.5|
      Atrium Left, Thrombosis              |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Hyperplasia, Diffuse        | 3              3              3                 3              3  2     2|     12  3.0|
      Capsule, Hyperplasia, Multifocal     |    3  3  3  4     2  3     3        2  2  1  4     3  3  3  2        3   |     32  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Accessory Adrenal Cortical Nodule    |                                                             X            |      2     |
      Angiectasis, Multifocal              |                                                                          |      1  3.0|
      Atrophy, Focal                       |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                   3                                   2                  |      2  2.5|
      Hypertrophy, Focal                   |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy, Multifocal                  |                                           4                              |      1  4.0|
      Hyperplasia, Multifocal              |                   2           2                                      1   |      3  1.7|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  M  M  M  +     +  M  M  M  M  M  +  +  M  +  +  +  +  M  +  +|  25        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |          3                                      2                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  M  +  +     +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +|  42        |
      Follicle, Cyst                       |                                                 3                        |      2  3.0|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 1| 1| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 4| 4| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 3| 2| 2| 1| 5| 4| 4| 0| 4| 4| 8| 8| 8| 2| 3| 3| 2| 2| 2| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                               +                                          |   1        |
      Cyst, Multifocal                     |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Angiectasis                          |                                                                          |      1  1.0|
      Cyst                                 |                               X                                   X  X   |      4     |
      Hyperplasia, Diffuse                 |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Dilatation                           |       4        3     4     3                       4     4  4  4     4   |     12  3.8|
      Hyperplasia, Cystic                  | 3  2     2  2  1     2     2              1  1  1     2  2        2  3  2|     29  1.6|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  3.0|
      Metaplasia, Squamous                 |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hypoplasia, Focal                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bronchial, Hyperplasia, Lymphoid     |    3                                3                                    |      2  3.0|
      Bronchial, Hyperplasia, Plasma Cell  |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                      3   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Hyperplasia, Lymphoid                |                                     3                                    |      3  3.3|
      Hyperplasia, Re Cell                 |                   2                                                      |      1  2.0|
      Pigmentation, Diffuse, Hemosiderin   |                   3        2                                             |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +     +  +  M  M  M  M  +  +  +  +  +  +  +  M  +  M|  32        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                                                          |      1  3.0|
      Depletion Lymphoid                   |                                                                          |      2  3.5|
      Developmental Malformation           |                                                             X            |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Hyperplasia, Plasma Cell             |          2                                                               |      1  2.0|
      Infarct                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
      Angiectasis, Multifocal              |                            3                                             |      1  3.0|
      Cyst, Multiple                       |                               2                                          |      1  2.0|
      Depletion Lymphoid                   |                                           3                              |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 1| 1| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 4| 4| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 3| 2| 2| 1| 5| 4| 4| 0| 4| 4| 8| 8| 8| 2| 3| 3| 2| 2| 2| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Ectopic Parathyroid Gland            |                                                                X     X   |      2     |
      Hyperplasia, Lymphoid                |                                                                      3   |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Ectasia, Multifocal                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  M  +  +  +  +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic Active, Diffuse|                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Fibrous Osteodystrophy               |                               3                 2  2        2     2      |      8  2.1|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization, Multifocal           | 1  2        1  2              1                 1     1        1  1      |     16  1.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  M  +  +     +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Crystals                             |                                                                          |      1  4.0|
      Edema                                |                                     4                                    |      1  4.0|
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Histiocyte                       |                   4                                                      |      2  4.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      | 2                    3                       2                           |      7  2.4|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Histiocyte                      |                                  2                                       |      4  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolus, Inflammation, Chronic      |                                                                          |            |
          Active, Focal                    |                                                                          |      1  2.0|
      Alveolus, Inflammation, Chronic      |                                                                          |            |
          Active, Multifocal               |                      1                                                   |      1  1.0|
      Bronchiole, Inflammation, Chronic    |                                                                          |            |
          Active, Focal                    |                                  1                                       |      1  1.0|
      Bronchiole, Alveolus, Inflammation,  |                                                                          |            |
           Chronic Active, Focal           |                                           1                              |      1  1.0|
      Bronchiole, Alveolus, Inflammation,  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 1| 1| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 4| 4| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 3| 2| 2| 1| 5| 4| 4| 0| 4| 4| 8| 8| 8| 2| 3| 3| 2| 2| 2| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Chronic Active, Multifocal      | 2  3  3  2  3  3  2        2  2              3  2  3  2  1  1  3  3  2  3|     35  2.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lumen, Crystals                      |                                  3  3  3                                 |      3  3.0|
      Mucosa, Inflammation, Chronic Active | 3  4  3  3  2  2  3  2     2  2  3  3  2  2  2  2  3  2  3  3  3  2  1  3|     47  2.6|
      Nasolacrimal Duct, Hyperplasia       |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                              3                           |      2  2.5|
      Respiratory Epithelium, Hyperplasia  | 4  4  4  4  4  4  4  4     4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4|     47  4.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Edema                                |                                     3                                    |      1  3.0|
      Metaplasia, Multifocal, Squamous     |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          | +                          +                                      +      |   5        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                            2                                             |      2  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                   2      |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    1        4                                      1              1     2|      7  1.9|
      Cortex, Regeneration, Multifocal     |                                     1                                    |      2  1.5|
      Cortex, Epithelium, Hyperplasia,     |                                                                          |            |
           Atypical, Multifocal            |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +|  40        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                          2           2   |      3  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |          1  2     3  1                       3                    2      |      9  1.7|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Mixed Cell                      |    3                                                                     |      1  3.0|
      Perforation                          |                                                                          |      1     |
      Serosa, Inflammation, Chronic        |          2                                                               |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 6| 9| 3| 3| 3| 3| 7| 3| 8| 9| 3| 3| 3| 3| 0| 3| 1|             
                                           | 5| 4| 5| 5| 5| 4| 9| 3| 5| 3| 3| 2| 2| 2| 9| 5| 2| 0| 5| 4| 4| 3| 6| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                 +                        |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                 +                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                 +                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                 +                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                 +                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                 +     +        +         |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                 +              +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                 +                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                 +                        |             
                                            __________________________________________________________________________|             
   Liver                                   |                      +  +  +              +  +  +              +        +|             
      Angiectasis, Focal                   |                                                                          |             
      Hematocyst                           |                                                                4         |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |             
      Centrilobular, Necrosis, Diffuse     |                                                 3                        |             
      Portal, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +           +                           |             
      Fat, Necrosis, Focal                 |                                                                          |             
      Fat, Necrosis, Multifocal            |                                  4           4                           |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                 +                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                 M                        |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                              +  +                        |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                              +  +                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                              +  +                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                 +                        |             
      Capsule, Hyperplasia, Diffuse        |                                                                          |             
      Capsule, Hyperplasia, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                 M                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                 M                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                 +                        |             
      Hyperplasia, Multifocal              |                                                 2                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                 +                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +                                         +                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 6| 9| 3| 3| 3| 3| 7| 3| 8| 9| 3| 3| 3| 3| 0| 3| 1|             
                                           | 5| 4| 5| 5| 5| 4| 9| 3| 5| 3| 3| 2| 2| 2| 9| 5| 2| 0| 5| 4| 4| 3| 6| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +              +                 +     +        +              +         |             
      Abscess, Multiple                    |                                                                          |             
      Cyst                                 | 4                                2     3                       4         |             
      Infiltration Cellular, Lymphocyte    |                                        2                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +           +  +  +  +  +  +     +  +     +     +  +|             
      Dilatation                           |                                                                4         |             
      Hyperplasia, Cystic                  | 2  2  2  3  2  2     3           3  2  2  3  2        2  3           2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                 +                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +                       +                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                 M                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                         +                       +                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                 2                        |             
                                            __________________________________________________________________________|             
   Spleen                                  |                         +  +              +     +     +                 +|             
      Hematopoietic Cell Proliferation     |                            4                    4                       4|             
                                            __________________________________________________________________________|             
   Thymus                                  |                         +                       M                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                 +                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +              +     +  +  +     +     +     +     +        +         |             
      Subcutaneous Tissue, Edema           |                         3                                                |             
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |             
           Acute                           |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +           +                                +                        |             
      Fibrous Osteodystrophy               |    1           1                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                 +                        |             
      Mineralization, Multifocal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                                                 +                        |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Crystals                             |       2                                                                  |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                2                                         1               |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |    1  2                                2     1                 2         |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      |                                     2  1                       1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 6| 9| 3| 3| 3| 3| 7| 3| 8| 9| 3| 3| 3| 3| 0| 3| 1|             
                                           | 5| 4| 5| 5| 5| 4| 9| 3| 5| 3| 3| 2| 2| 2| 9| 5| 2| 0| 5| 4| 4| 3| 6| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active, Focal  |                                                    3                     |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Inflammation, Chronic      |                                                                          |             
          Active, Multifocal               |                                                                          |             
      Bronchiole, Hyperplasia, Focal       |                                                                          |             
      Bronchiole, Hyperplasia, Multifocal  |                      2                                                   |             
      Bronchiole, Alveolus, Inflammation,  |                                                                          |             
           Chronic Active, Focal           |                3     1                          1                    2   |             
      Bronchiole, Alveolus, Inflammation,  |                                                                          |             
           Chronic Active, Multifocal      | 1     3  2        2                                                     1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Exudate                              |                      2                                                   |             
      Mucosa, Inflammation, Chronic Active | 3  2  2  2  2  2  1  3  2  3  2  2  1  2  2  2  2  3  3  3  2  4     1  3|             
      Respiratory Epithelium, Hyperplasia  | 3  3  3  3  2  3  2  3  3  4  3  3  3  2  3  3  2  4  4  4  3  3     2  4|             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                         +  +                    +              +         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3|            |
                                           | 6| 3| 2| 2| 1| 5| 5| 5| 5| 7| 4| 6| 3| 4| 3| 3| 3| 2| 2| 1| 5| 5| 5| 9| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                      M   |   1        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                           +                          +   |   2        |
      Dilatation                           |                                           4                              |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                      +   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                      +   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                      +   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                      M   |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                              +           +           +   |   6        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                      +   |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                      +   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                      A   |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +           +        +  +  +     +        +                          +   |  16        |
      Angiectasis, Focal                   |                                           3                              |      1  3.0|
      Hematocyst                           |                                                                          |      1  4.0|
      Bile Duct, Hyperplasia, Multifocal   |                                           4                              |      1  4.0|
      Centrilobular, Necrosis, Diffuse     |                                                                          |      1  3.0|
      Portal, Inflammation, Chronic        |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   3        |
      Fat, Necrosis, Focal                 | 2                                                                        |      1  2.0|
      Fat, Necrosis, Multifocal            |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                           +                          +   |   3        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                      +   |   1        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                      +   |   3        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                      +   |   3        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                      +   |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                      +   |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                        +                             +   |   3        |
      Capsule, Hyperplasia, Diffuse        |                                        4                                 |      1  4.0|
      Capsule, Hyperplasia, Multifocal     |                                                                      1   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                        +                             +   |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                        +                             +   |   2        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                           +                          +   |   3        |
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                      M   |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3|            |
                                           | 6| 3| 2| 2| 1| 5| 5| 5| 5| 7| 4| 6| 3| 4| 3| 3| 3| 2| 2| 1| 5| 5| 5| 9| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +        +                                                     +   |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                      +   |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +           +           +  +  +              +                    +  +|  14        |
      Abscess, Multiple                    |                                  4                                       |      1  4.0|
      Cyst                                 |    X           4           X  3                                         3|      9  3.3|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +  +     +  +  +  +        +     +  +     +  +  +  +  +  +  +  +|  37        |
      Dilatation                           | 4                          4                       4                    4|      5  4.0|
      Hyperplasia, Cystic                  |    2     4  3     3  2  3           2     2  2        2  2     2  1     2|     29  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                      +   |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                            +  +  +     +                 +           +   |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                      +   |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                            +     +     +                 +           M   |   6        |
      Hematopoietic Cell Proliferation     |                            3                             2               |      2  2.5|
      Hemorrhage                           |                            3                             2               |      3  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +           +              +     +     +     +                       +   |  13        |
      Hematopoietic Cell Proliferation     |                            3     4     4                                 |      6  3.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                      +   |   2        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                      M   |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +        +  +        +           +           +     +              +   |  20        |
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +              +     +           +  +     +     +     +     +   |  12        |
      Fibrous Osteodystrophy               |          3              1     1           3  2     2     2     3         |     10  1.9|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                      +   |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3|            |
                                           | 6| 3| 2| 2| 1| 5| 5| 5| 5| 7| 4| 6| 3| 4| 3| 3| 3| 2| 2| 1| 5| 5| 5| 9| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mineralization, Multifocal           |                                                                      1   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                                                                      M   |   1        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Crystals                             | 4                    4                             4                     |      4  3.5|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |    2                    2                                                |      4  1.8|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    1  1                 2                                1  2            |     10  1.5|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Histiocyte                      |                      2                          2              1         |      6  1.5|
      Inflammation, Chronic Active, Focal  |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                     2                                    |      1  2.0|
      Alveolus, Inflammation, Chronic      |                                                                          |            |
          Active, Multifocal               |                                                    3                     |      1  3.0|
      Bronchiole, Hyperplasia, Focal       |                                                                   2      |      1  2.0|
      Bronchiole, Hyperplasia, Multifocal  |                                                                          |      1  2.0|
      Bronchiole, Alveolus, Inflammation,  |                                                                          |            |
           Chronic Active, Focal           |                      4                                                   |      5  2.2|
      Bronchiole, Alveolus, Inflammation,  |                                                                          |            |
           Chronic Active, Multifocal      | 3           2                 1              2                           |      9  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Exudate                              |                                                                      3   |      2  2.5|
      Mucosa, Inflammation, Chronic Active | 4  2  3  2  2  2  3  3  2  3  2  3  3  2  3  3  2  2  2  2  3  3  2  2  2|     49  2.4|
      Respiratory Epithelium, Hyperplasia  | 4  3  4  4  3  4  3  4  3  4  4  4  3  4  4  3  3  3  3  4  4  4  3  3  3|     49  3.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                      +   |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                      +     +                                         +   |   7        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                      +   |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 2| 7| 6| 7|             
                             DAY ON TEST   | 7| 1| 8| 3| 6| 9| 7| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 0| 3| 6| 3| 5| 3|             
                                           | 3| 7| 7| 2| 7| 6| 0| 2| 2| 2| 5| 4| 9| 3| 3| 3| 3| 3| 2| 7| 2| 6| 1| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anisokaryosis                        |                                     3                                    |             
      Basophilic Focus                     |       X                                         X                        |             
      Cyst Multilocular                    |                                              X                    3      |             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Infarct, Single                      |                   4                                                      |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      |                   2                                                      |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Karyomegaly, Multifocal              |             2                                                            |             
      Necrosis, Acute, Multifocal          |             2                                                        3   |             
      Necrosis, Multifocal, Subacute       | 3                                                                        |             
      Syncytial Alteration, Multifocal     |                                  2                                       |             
      Median Lobe, Congestion, Diffuse     |                                                          4               |             
      Median Lobe, Fibrosis                |                                                          3               |             
      Median Lobe, Thrombosis              |                                                          4               |             
      Median Lobe, Hepatocyte, Atrophy,    |                                                                          |             
           Diffuse                         |                                                          4               |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +        +  +                                                      |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2                                                                        |             
      Inflammation, Acute, Focal           |                3                                                         |             
      Artery, Adventitia, Infiltration     |                                                                          |             
          Cellular, Focal, Mixed Cell      |       3                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Acinus, Atrophy, Multifocal          | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 2| 7| 6| 7|             
                             DAY ON TEST   | 7| 1| 8| 3| 6| 9| 7| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 0| 3| 6| 3| 5| 3|             
                                           | 3| 7| 7| 2| 7| 6| 0| 2| 2| 2| 5| 4| 9| 3| 3| 3| 3| 3| 2| 7| 2| 6| 1| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinus, Hyperplasia, Focal           |                         3                                                |             
      Acinus, Hypertrophy, Multifocal      |                   2                                                      |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Focal                           |                                     3                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 1  1  1              1  2                    1  2     2  1               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                               2                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Embolus, Single              |                                                                          |             
      Coronary Artery, Infiltration        |                                                                          |             
          Cellular, Focal, Mixed Cell      |       3                                                                  |             
      Mitral Valve, Pigmentation, Focal,   |                                                                          |             
           Hemosiderin                     |                      3                                                   |             
      Myocardium, Inflammation, Chronic    |                                                                          |             
          Active, Multifocal               |                                                                          |             
      Perivascular, Inflammation, Acute,   |                                                                          |             
           Focal                           |                                                                          |             
      Ventricle, Karyomegaly, Multifocal   |                3                                                         |             
      Ventricle Left, Bacterium            |                                                                          |             
      Ventricle Left, Inflammation, Focal, |                                                                          |             
           Subacute                        |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia, Focal          |                                              1                 1        3|             
      Capsule, Hyperplasia, Multifocal     | 1  1  2  1           2  2  2     4  2  2  3     3  4  3  2  2     3      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                    X                     |             
      Hyperplasia, Focal                   |                                                             3            |             
      Hyperplasia, Multifocal              |                                  3                                       |             
      Hypertrophy, Focal                   |                                              2        2           2      |             
      Hypertrophy, Multifocal              |                      2  2                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Multifocal              |                                                                      2   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 2| 7| 6| 7|             
                             DAY ON TEST   | 7| 1| 8| 3| 6| 9| 7| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 0| 3| 6| 3| 5| 3|             
                                           | 3| 7| 7| 2| 7| 6| 0| 2| 2| 2| 5| 4| 9| 3| 3| 3| 3| 3| 2| 7| 2| 6| 1| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +|             
      Pars Distalis, Cyst                  |                                                             2           2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicular Cell, Hyperplasia         |          1                                                               |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +                                                                        |             
      Inflammation, Chronic Active         | 3                                                                        |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +     +     +  +           +        +     +  +        +         |             
      Abscess                              |          3                                            3                  |             
      Cyst                                 |       X        X                             X        X                  |             
      Cyst Multilocular                    |                         X                                                |             
      Inflammation, Chronic                |                3     3              2                                    |             
      Inflammation, Chronic Active         |       3  4              3                    4     4                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Inflammation, Chronic Active         |             4                                                        2   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                      3   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |          2                                      2     3                  |             
      Seminiferous Tubule, Degeneration,   |                                                                          |             
           Multifocal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            | 3           3                                                        2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Re Cell       |                                                                          |             
      Lumbar, Hemorrhage                   |                                              4                           |             
      Lumbar, Hyperplasia, Lymphoid        |          3                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             
      Hematopoietic Cell Proliferation     | 4     2  3                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 2| 7| 6| 7|             
                             DAY ON TEST   | 7| 1| 8| 3| 6| 9| 7| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 0| 3| 6| 3| 5| 3|             
                                           | 3| 7| 7| 2| 7| 6| 0| 2| 2| 2| 5| 4| 9| 3| 3| 3| 3| 3| 2| 7| 2| 6| 1| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           | 2        3                    3     3  3  2  3        3     2     3      |             
      Hyperplasia, Re Cell                 |                                     3                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     | 4     2     2  2                    3                    3           3   |             
      Hyperplasia, Lymphoid                |                                                       3                  |             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M|             
      Depletion Lymphoid                   |                                                                          |             
      Syncytial Alteration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  M  M  M  +  +  M  M  +  M  M  M  M  +  M  M  M  M  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Prepuce, Necrosis                    | 4                                                                        |             
      Prepuce, Ulcer                       |       4           4                                                      |             
      Subcutaneous Tissue, Cyst            |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Granulomatous            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Sternum, Developmental Malformation  |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                 2                        |             
      Mineralization, Focal                |                                                 1                        |             
      Mineralization, Multifocal           |    4  2  2     2  2     3     3  2  3  2  2        1        2     3      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Histiocyte                       |                3                                                         |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                             1            |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                         2|             
      Interstitium, Inflammation, Acute,   |                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 2| 7| 6| 7|             
                             DAY ON TEST   | 7| 1| 8| 3| 6| 9| 7| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 0| 3| 6| 3| 5| 3|             
                                           | 3| 7| 7| 2| 7| 6| 0| 2| 2| 2| 5| 4| 9| 3| 3| 3| 3| 3| 2| 7| 2| 6| 1| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Acute          |                      2                             1                     |             
      Mucosa, Inflammation, Chronic        |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                   2                                                      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |       1                 1                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Single                         |                                                    3                     |             
      Embolus, Multifocal                  |                                                                          |             
      Hydronephrosis                       |       3              3                                                   |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                             1            |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                1                          1  2  2                        |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Mixed Cell                      | 1                                                                        |             
      Inflammation, Acute, Multifocal,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal, Suppurative          |             4                                                        4   |             
      Mineralization, Focal                |                                                                          |             
      Cortex, Renal Tubule, Epithelium,    |                                                                          |             
           Hyperplasia, Atypical, Focal    |                2                                                         |             
                                            __________________________________________________________________________|             
   Urethra                                 |             +                                                            |             
      Calculus Micro Observation Only      |             X                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      | X                                                                        |             
      Embolus                              |                                                                          |             
      Inflammation, Chronic Active, Diffuse| 4                                                                        |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 3| 3| 4| 3| 8| 1| 3| 3|            |
                                           | 5| 4| 4| 3| 3| 4| 3| 3| 2| 2| 2| 2| 7| 1| 4| 5| 5| 4| 4| 8| 3| 8| 4| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  M  +  A  +  +|  41        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +     +  +  M  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Anisokaryosis                        |                                                                          |      1  3.0|
      Basophilic Focus                     |                                                                          |      2     |
      Cyst Multilocular                    |                                                                          |      2  3.0|
      Fatty Change, Focal                  |                                                                      2   |      1  2.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                               2                                          |      1  2.0|
      Infarct, Single                      |                                                                          |      1  4.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                            1                                             |      1  1.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Inflammation, Acute, Multifocal      |                                                                3         |      1  3.0|
      Karyomegaly, Multifocal              |                                                                          |      1  2.0|
      Necrosis, Acute, Multifocal          |                                                                          |      2  2.5|
      Necrosis, Multifocal, Subacute       |                                                                          |      1  3.0|
      Syncytial Alteration, Multifocal     |                                                                          |      1  2.0|
      Median Lobe, Congestion, Diffuse     |                                                                          |      1  4.0|
      Median Lobe, Fibrosis                |                                                                          |      1  3.0|
      Median Lobe, Thrombosis              |                                                                          |      1  4.0|
      Median Lobe, Hepatocyte, Atrophy,    |                                                                          |            |
           Diffuse                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                              +         |   6        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                3         |      2  2.5|
      Inflammation, Acute, Focal           |                                                                          |      1  3.0|
      Artery, Adventitia, Infiltration     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 3| 3| 4| 3| 8| 1| 3| 3|            |
                                           | 5| 4| 4| 3| 3| 4| 3| 3| 2| 2| 2| 2| 7| 1| 4| 5| 5| 4| 4| 8| 3| 8| 4| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
          Cellular, Focal, Mixed Cell      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                    2                     |      1  2.0|
      Acinus, Atrophy, Multifocal          |                                                                          |      1  2.0|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  3.0|
      Acinus, Hypertrophy, Multifocal      |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    2  2  1  3        2     2     2     1  2     2  2  1     2        1  2|     24  1.6|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +|  48        |
      Hyperplasia, Focal, Squamous         |    2                                                                     |      1  2.0|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Embolus, Single              |                                                                   3      |      1  3.0|
      Coronary Artery, Infiltration        |                                                                          |            |
          Cellular, Focal, Mixed Cell      |                                                                          |      1  3.0|
      Mitral Valve, Pigmentation, Focal,   |                                                                          |            |
           Hemosiderin                     |                                                                          |      1  3.0|
      Myocardium, Inflammation, Chronic    |                                                                          |            |
          Active, Multifocal               |                                                                   2      |      1  2.0|
      Perivascular, Inflammation, Acute,   |                                                                          |            |
           Focal                           |                                                                   3      |      1  3.0|
      Ventricle, Karyomegaly, Multifocal   |                                                                          |      1  3.0|
      Ventricle Left, Bacterium            |                                                                   X      |      1     |
      Ventricle Left, Inflammation, Focal, |                                                                          |            |
           Subacute                        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Capsule, Hyperplasia, Focal          |                                                                          |      3  1.7|
      Capsule, Hyperplasia, Multifocal     | 2  1  1  2  2  1     3  2  1  2     2  3  1  3  3     3     2        2  2|     36  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 3| 3| 4| 3| 8| 1| 3| 3|            |
                                           | 5| 4| 4| 3| 3| 4| 3| 3| 2| 2| 2| 2| 7| 1| 4| 5| 5| 4| 4| 8| 3| 8| 4| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Hyperplasia, Focal                   |                            2     3                    2                 4|      5  2.8|
      Hyperplasia, Multifocal              |    3                 2                             3           1     2   |      6  2.3|
      Hypertrophy, Focal                   |                   1     2  2                                            2|      7  1.9|
      Hypertrophy, Multifocal              |          2  2                    2                    2                  |      6  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Hyperplasia, Multifocal              |                         3           2     2                 2     3  3   |      7  2.4|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  M  M  +  M  +  +  +  +  M  M  +  M  +  +  +  +  M  +  M  +|  36        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  M  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  45        |
      Pars Distalis, Cyst                  |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ultimobranchial Cyst                 |                                                                   X      |      1     |
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                         +                       +  +  +           +      |  15        |
      Abscess                              |                         4                          4  2           3      |      6  3.2|
      Cyst                                 |                                                 4                        |      5  4.0|
      Cyst Multilocular                    |                                                                          |      1     |
      Inflammation, Chronic                |                                                                          |      3  2.7|
      Inflammation, Chronic Active         |                                                       4           3      |      7  3.6|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                      2                                                   |      1  2.0|
      Inflammation, Acute, Suppurative     |                                                                4         |      1  4.0|
      Inflammation, Chronic Active         |                                                                   3      |      3  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +|  48        |
      Dilatation                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 3| 3| 4| 3| 8| 1| 3| 3|            |
                                           | 5| 4| 4| 3| 3| 4| 3| 3| 2| 2| 2| 2| 7| 1| 4| 5| 5| 4| 4| 8| 3| 8| 4| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Seminiferous Tubule, Atrophy         |                                                                          |      3  2.3|
      Seminiferous Tubule, Degeneration,   |                                                                          |            |
           Multifocal                      |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Myeloid Cell, Hyperplasia            |                3                          2                              |      5  2.6|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Re Cell       |                                                                2         |      1  2.0|
      Lumbar, Hemorrhage                   |                                                                          |      1  4.0|
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
      Hyperplasia, Re Cell                 |                            2        2     3                              |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  M  +  +  M  +  +|  42        |
      Hematopoietic Cell Proliferation     |                2  3                       3                              |      6  2.8|
      Hemorrhage                           |    2        2     2  1  2  3  4     4     2  3     2  2     3  3        3|     25  2.6|
      Hyperplasia, Re Cell                 |                         3                                                |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Depletion Lymphoid                   |                         3                                                |      1  3.0|
      Hematopoietic Cell Proliferation     |                4              2           3                       2      |     11  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia, Re Cell                 |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  M  M  +  +  M  +  +  +  +  M  +  +  M  M  A  +  M  +  +  +|  35        |
      Depletion Lymphoid                   |                                                                   4      |      1  4.0|
      Syncytial Alteration                 |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  M  M  M  M  +  M  M  M  +  M  M  M  M  M  M  +  M  M  M  M  +  M|  11        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                   2                                                      |      1  2.0|
      Prepuce, Necrosis                    |                4                          4                              |      3  4.0|
      Prepuce, Ulcer                       |                                                                          |      2  4.0|
      Subcutaneous Tissue, Cyst            |                                     3                                    |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Granulomatous            |                                     3                                    |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                                                             3            |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 3| 3| 4| 3| 8| 1| 3| 3|            |
                                           | 5| 4| 4| 3| 3| 4| 3| 3| 2| 2| 2| 2| 7| 1| 4| 5| 5| 4| 4| 8| 3| 8| 4| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Sternum, Developmental Malformation  |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                                                                          |      1  2.0|
      Mineralization, Focal                |                                                                          |      1  1.0|
      Mineralization, Multifocal           |       1        2  2              2     2     2     4  1  2  4  3     3   |     26  2.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  M|  44        |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Histiocyte                       |                                                                          |      1  3.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |          2  1        1                                                  1|      5  1.2|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                             4            |      2  3.0|
      Interstitium, Inflammation, Acute,   |                                                                          |            |
           Focal                           |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Inflammation, Acute          |                   1                                                      |      3  1.3|
      Mucosa, Inflammation, Chronic        |                                                 1                        |      1  1.0|
      Mucosa, Inflammation, Chronic Active |       1                                                                  |      2  1.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         | 2                                                                        |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |       1                             1                                1   |      5  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Cyst, Single                         |                                                                          |      1  3.0|
      Embolus, Multifocal                  |                                                                   3      |      1  3.0|
      Hydronephrosis                       |                                           2                              |      3  2.7|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 3| 3| 4| 3| 8| 1| 3| 3|            |
                                           | 5| 4| 4| 3| 3| 4| 3| 3| 2| 2| 2| 2| 7| 1| 4| 5| 5| 4| 4| 8| 3| 8| 4| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |       2                 2                 1  1                       1   |      9  1.4|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Mixed Cell                      |                                                                          |      1  1.0|
      Inflammation, Acute, Multifocal,     |                                                                          |            |
           Suppurative                     |                                                                   4      |      1  4.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal, Suppurative          |                                                                          |      2  4.0|
      Mineralization, Focal                |                            1                                             |      1  1.0|
      Cortex, Renal Tubule, Epithelium,    |                                                                          |            |
           Hyperplasia, Atypical, Focal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Calculus Micro Observation Only      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Calculus Micro Observation Only      |                                                                   X      |      2     |
      Embolus                              |                                                                   4      |      1  4.0|
      Inflammation, Chronic Active, Diffuse|                                                                          |      1  4.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                   3      |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 8| 8| 2| 2| 2| 2| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    25 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Lymphoid         |                            3                                             |             
      Mucosa, Necrosis, Acute              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                                                                          |             
      Basophilic Focus, Multiple           |                                                 X                        |             
      Cyst Multilocular                    |                                                                          |             
      Cytomegaly, Focal                    |                2                                                         |             
      Degeneration, Ballooning, Multifocal |          1                                                               |             
      Fatty Change, Focal                  |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      X                                                   |             
      Necrosis, Acute, Focal               |                                                    4                     |             
      Necrosis, Acute, Multifocal          |                                                                          |             
      Syncytial Alteration, Focal          |                                              1                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +              +                    +                        |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                            2                                             |             
      Fat, Inflammation, Chronic Active,   |                                                                          |             
           Focal                           |             2                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |             2                    2                                       |             
      Acinus, Hypertrophy, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                     2                                    |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 1  2                    2  3     3     2     2     3           2  2     2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia, Focal       |                                     1                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active, Focal  |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 8| 8| 2| 2| 2| 2| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    25 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Multifocal                       |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia, Focal          |             2                                2                           |             
      Capsule, Hyperplasia, Multifocal     | 2              3     3  2  4  4  3  3  3  3     3  2  3  2  2  3  2  4  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                   X      |             
      Hyperplasia, Focal                   |                3                                2        2               |             
      Hyperplasia, Multifocal              |                                                    3        1           2|             
      Hypertrophy, Focal                   |                         2     4        4  1                              |             
      Hypertrophy, Multifocal              | 4                                                                 2  3   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                           3                              |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                      2           2                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |    2                                                                     |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Ultimobranchial Cyst                 |                      X                    X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                     +  +                    +            |             
      Cyst                                 |                                     3  2                    3            |             
                                            __________________________________________________________________________|             
   Prostate                                | M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Left, Hemorrhage                     |                                                                          |             
      Seminiferous Tubule, Atrophy         |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 8| 8| 2| 2| 2| 2| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    25 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Hemorrhage                |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia, Lymphoid                |                            2                                            2|             
      Hyperplasia, Re Cell                 |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  M  M  +  +  +  +        +  +  +  +  +  +  +  +  M  M  +  +  +  M  +|             
      Hemorrhage                           |             3  4  3  2                       2  3  3        2           3|             
      Hyperplasia, Lymphoid                |                                                    2        2            |             
      Hyperplasia, Re Cell                 |                      3                 3                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                                                       2                  |             
      Hematopoietic Cell Proliferation     |                   3                                                      |             
      Hyperplasia, Diffuse, Lymphoid       |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Thrombosis                           |                                                                          |             
      Lymphocyte, Necrosis, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +|             
      Cyst, Multiple                       |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Hyperplasia, Diffuse, Lymphoid       |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  M  +  +  M  M  M  M  M  M  M  +  +  +  +  +  +  +  M  M  M  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteoporosis, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           |    2                 1  2  1                 2     3  2  1  1  2        2|             
      Artery, Meninges, Inflammation,      |                                                                          |             
          Chronic, Multifocal              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Inflammation, Acute, Diffuse         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 8| 8| 2| 2| 2| 2| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    25 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic, Multifocal    |             1                                                            |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Granuloma                            |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                     1                                    |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal, Histiocyte          |                                                       2                  |             
      Alveolus, Inflammation, Chronic      |                                                                          |             
          Active, Focal                    |                2                                                         |             
      Alveolus, Inflammation, Chronic      |                                                                          |             
          Active, Multifocal               | 1                                                     2              1   |             
      Bronchiole, Alveolus, Inflammation,  |                                                                          |             
           Chronic Active, Focal           |                                                                          |             
      Bronchiole, Alveolus, Inflammation,  |                                                                          |             
           Chronic Active, Multifocal      |    2  3     2     2  2  2  1  2  2        4  2  1  1     3  2     2      |             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Multifocal, Lymphocyte          |                                                                          |             
      Pleura, Hyperplasia, Diffuse         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Acute          |          1                                                               |             
      Mucosa, Inflammation, Chronic Active | 2  2  3     3  3  3  3  3  2  3  2  4  2  3  3  2  3  4  3  3  2  2  3  2|             
      Respiratory Epithelium, Hyperplasia  | 3  3  4  4  4  4  4  3  4  3  4  4  4  4  4  4  4  4  4  4  4  4  3  4  4|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |             1                                                            |             
      Glands, Hyperplasia, Diffuse         |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Left, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Degeneration, Chronic, Focal, Two    |                                                    4                     |             
      Degeneration, Chronic, Multifocal    |                                                    4                     |             
      Hydronephrosis                       |    2                                                                     |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 8| 8| 2| 2| 2| 2| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    25 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                   2                                                      |             
      Nephropathy, Chronic                 |                            2        1                                    |             
      Artery, Inflammation                 |                                                    4                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 0| 0| 3| 3| 3| 6| 3|            |
                                           | 5| 5| 5| 5| 5| 6| 2| 5| 4| 4| 3| 3| 3| 3| 3| 4| 3| 5| 3| 2| 5| 5| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  +  M  M  A  M  +  +  +  +  +  +  +  M  +  +  +  M  M  +  M  A  +|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Hyperplasia, Focal, Lymphoid         |                                                                          |      1  3.0|
      Mucosa, Necrosis, Acute              |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     M  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis, Multifocal              |                                                                      3   |      1  3.0|
      Basophilic Focus, Multiple           |                                                                          |      1     |
      Cyst Multilocular                    |                                                                   4      |      1  4.0|
      Cytomegaly, Focal                    |                                                                          |      1  2.0|
      Degeneration, Ballooning, Multifocal |                                                                          |      1  1.0|
      Fatty Change, Focal                  |                                                             2            |      1  2.0|
      Fibrosis, Focal                      |                               2                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Necrosis, Acute, Focal               |                                                                          |      1  4.0|
      Necrosis, Acute, Multifocal          |                                                       3              4   |      2  3.5|
      Syncytial Alteration, Focal          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Fat, Inflammation, Chronic Active,   |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      2  2.0|
      Acinus, Hypertrophy, Focal           | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    2  1        1           1     1  2  1        2  2        2     2  2  1|     24  1.8|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 0| 0| 3| 3| 3| 6| 3|            |
                                           | 5| 5| 5| 5| 5| 6| 2| 5| 4| 4| 3| 3| 3| 3| 3| 4| 3| 5| 3| 2| 5| 5| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|  47        |
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active, Focal  |                                           2                              |      1  2.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|  48        |
      Capsule, Hyperplasia, Focal          |                                                                          |      2  2.0|
      Capsule, Hyperplasia, Multifocal     |    3  2  2  2  2     2     2  4  2  2  2  2     2  2     1  2  2  2  2  3|     39  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|  48        |
      Accessory Adrenal Cortical Nodule    |             X           X                                                |      3     |
      Hyperplasia, Focal                   |             2           1     2           2                              |      7  2.0|
      Hyperplasia, Multifocal              |    2                                                        3            |      5  2.2|
      Hypertrophy, Focal                   | 2                       2                 2        2                     |      8  2.4|
      Hypertrophy, Multifocal              |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                            3                                             |      2  3.0|
      Hyperplasia, Multifocal              |                         2           2                    2     2         |      4  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  +  +  M  +  M  +  +  +  +  M  +  M  M  +  +  +  +  +  M  +  +|  35        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  I  +|  47        |
      Pars Distalis, Cyst                  |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                 2                        |      1  2.0|
      Ultimobranchial Cyst                 |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                 +                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 0| 0| 3| 3| 3| 6| 3|            |
                                           | 5| 5| 5| 5| 5| 6| 2| 5| 4| 4| 3| 3| 3| 3| 3| 4| 3| 5| 3| 2| 5| 5| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +        +                 +  +                 +               |   8        |
      Cyst                                 |          4        2                 X  X                 4               |      8  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Left, Hemorrhage                     |                                                                      4   |      1  4.0|
      Seminiferous Tubule, Atrophy         |                                                 3                    4   |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bronchial, Hemorrhage                |                                                                      2   |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  M  +  M  M  M  +  M  +  +  +  M  +  M  M  +  +  +  M  +  +  +|  35        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Hyperplasia, Re Cell                 |                                                                   2  2   |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  M  M  M  M  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  M|  33        |
      Hemorrhage                           |                                        2                 2  4  2  3      |     14  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Hyperplasia, Re Cell                 |                                                                      2   |      3  2.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis, Multifocal              |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                2         |      2  2.5|
      Hyperplasia, Diffuse, Lymphoid       |       4                                                                  |      1  4.0|
      Hyperplasia, Lymphoid                |       4                                                                  |      1  4.0|
      Hyperplasia, Plasma Cell             |                                                                3         |      1  3.0|
      Thrombosis                           |                            3                                             |      1  3.0|
      Lymphocyte, Necrosis, Multifocal     |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  M  M  M  +  +  I  +  +  +  M  +  +  M  M  +  +  M  +  M|  34        |
      Cyst, Multiple                       |             2                                                            |      1  2.0|
      Depletion Lymphoid                   |                2                                                         |      1  2.0|
      Hyperplasia, Diffuse, Lymphoid       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  +  +  M  M  M  M  +  M  M  +  M  +  M  +  +  M  +  +  M  M  M|  21        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 0| 0| 3| 3| 3| 6| 3|            |
                                           | 5| 5| 5| 5| 5| 6| 2| 5| 4| 4| 3| 3| 3| 3| 3| 4| 3| 5| 3| 2| 5| 5| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteoporosis, Focal                  |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization, Multifocal           | 2  1                 2  2     2     1  1  1                 2     2      |     21  1.7|
      Artery, Meninges, Inflammation,      |                                                                          |            |
          Chronic, Multifocal              |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Acute, Diffuse         |                      1                                                   |      1  1.0|
      Inflammation, Chronic, Multifocal    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                                          2               |      1  2.0|
      Granuloma                            |                4                                                         |      1  4.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |    3                                                                     |      1  3.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |          2           3                                                   |      3  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Histiocyte                      |                                                       3                  |      1  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Histiocyte          |                                                                          |      1  2.0|
      Alveolus, Inflammation, Chronic      |                                                                          |            |
          Active, Focal                    |                                                                          |      1  2.0|
      Alveolus, Inflammation, Chronic      |                                                                          |            |
          Active, Multifocal               |                                                                          |      3  1.3|
      Bronchiole, Alveolus, Inflammation,  |                                                                          |            |
           Chronic Active, Focal           |    3                                                                     |      1  3.0|
      Bronchiole, Alveolus, Inflammation,  |                                                                          |            |
           Chronic Active, Multifocal      | 2     2        3  2  2  4     2  4        4        3           2     2  3|     29  2.3|
      Mediastinum, Infiltration Cellular,  |                                                                          |            |
           Multifocal, Lymphocyte          |                      2  2                                                |      2  2.0|
      Pleura, Hyperplasia, Diffuse         |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 0| 0| 3| 3| 3| 6| 3|            |
                                           | 5| 5| 5| 5| 5| 6| 2| 5| 4| 4| 3| 3| 3| 3| 3| 4| 3| 5| 3| 2| 5| 5| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Inflammation, Acute          |                                                                          |      1  1.0|
      Mucosa, Inflammation, Chronic Active | 2  3  3  3  4  3  2  4  4  4  3  2  3  3  3     2  3  3  2  4  4  4  1  4|     48  2.9|
      Respiratory Epithelium, Hyperplasia  | 4  4  4  4  4  4  3  4  3  4  4  4  4  4  4     4  4  4  4  4  4  4  4  4|     49  3.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Glands, Hyperplasia, Diffuse         |    3                                                                     |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                       +                  |   1        |
      Cornea, Left, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                       4                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                          3               |      1  3.0|
      Degeneration, Chronic, Focal, Two    |                                                                          |      1  4.0|
      Degeneration, Chronic, Multifocal    |                                                                          |      1  4.0|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                     1              1                     |      3  1.3|
      Nephropathy, Chronic                 |       2                                                                  |      3  1.7|
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 3| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 6| 3| 5| 3| 2| 3| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|             
                                           | 3| 2| 7| 1| 3| 1| 4| 2| 4| 6| 5| 5| 5| 5| 8| 4| 4| 4| 3| 3| 2| 2| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +           +  +  +                 M        +                     |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +           +  +  +  +              M                              |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +           +  +  +                 +        +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | M     +           +  +  +                 +        A                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +           +  +  +                 +        +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +           +  +  +                 M        A                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +           +  +  +     +           +        +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +           +  +  +     +           +        A                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +           +  +  +     +           +        A                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +           +  +  +     +           +        A                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +     +  +  +     +           +  +     +  +                  |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Necrosis, Acute, Focal               | 1                                                                        |             
      Necrosis, Acute, Multifocal          |    3                 4                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +           +  +  +                 +        A                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +           +  +  +                 +        +                     |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |       1                                                                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +           +  +  +                 +        +              +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +           +  +  +                 +        +                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +           +  +  +                 +        +              +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +           +  +  +                 +     +  +                     |             
      Cardiomyopathy                       |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +           +  +  +                 +        +                     |             
      Capsule, Hyperplasia, Multifocal     | 1                 2                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +           +  +  +                 +        +                     |             
      Hypertrophy, Focal                   |                         2                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +           M  +  +                 +        +                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +           +  +  +                 +        A                     |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     M           M  +  +                 M        +                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +           +  +  +                 +        +                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +           +  +  +                 M        +                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                   +                                                      |             
      Inflammation, Chronic Active,        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 3| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 6| 3| 5| 3| 2| 3| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|             
                                           | 3| 2| 7| 1| 3| 1| 4| 2| 4| 6| 5| 5| 5| 5| 8| 4| 4| 4| 3| 3| 2| 2| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
          Multifocal                       |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +           +  +  +                 +        +                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +                                            +                    +   |             
      Abscess                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Dilatation                           |                                                 3                        |             
      Inflammation, Chronic                |                                                 2                    2   |             
                                            __________________________________________________________________________|             
   Prostate                                | M     +           +  +  +                 +        +                     |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +     +     +  +  +  +              M        +              +     +|             
      Dilatation                           |                                                                         3|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +           +  +  +                 +        +                     |             
      Seminiferous Tubule, Atrophy         |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +           +  +  +                 M        +                     |             
      Myeloid Cell, Hyperplasia            | 3                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +           +  +  +     +        +  +  +     +  +     +           +|             
      Angiectasis, Focal                   |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M     +           +  +  +                 +        M                    +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +           +  +  +     +        +  M  +     M  +     +           +|             
      Hematopoietic Cell Proliferation     |                                                       2                  |             
      Hemorrhage                           |       4              4  2              2     2        3     2           2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +        +  +  +                 +        A                    +|             
      Hematopoietic Cell Proliferation     | 4     3                 3                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +           M  M  +                 M        M                     |             
      Depletion Lymphoid                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     M           M  M  M                 M        M                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +        +  +  +  +     +  +     +  +  +  +  +  +        +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
      Prepuce, Abscess                     | 4                                                                        |             
      Prepuce, Inflammation, Chronic Active|                                                                          |             
      Prepuce, Ulcer                       | 4                                                                        |             
      Scrotal, Pigmentation, Focal, Melanin|                                                          4               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 3| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 6| 3| 5| 3| 2| 3| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|             
                                           | 3| 2| 7| 1| 3| 1| 4| 2| 4| 6| 5| 5| 5| 5| 8| 4| 4| 4| 3| 3| 2| 2| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Scrotal, Hair Follicle, Hyperplasia, |                                                                          |             
           Focal                           |                                                          2               |             
      Subcutaneous Tissue, Abscess         |                                                                          |             
      Subcutaneous Tissue, Edema           |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +           +  +  +                 M        +                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +           +  +  +                 +        +                     |             
      Mineralization, Multifocal           |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | M     +           +  +  M                 M        M                     |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                                                                         1|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                     2                                    |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      |                                           3                              |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                      2                                                   |             
      Alveolus, Inflammation, Chronic      |                                                                          |             
          Active, Focal                    |                                                                          |             
      Bronchiole, Hyperplasia, Focal       |                                                                          |             
      Bronchiole, Hyperplasia, Multifocal  |                            2  1           1                              |             
      Bronchiole, Inflammation, Chronic,   |                                                                          |             
           Focal                           |                                        1                                 |             
      Bronchiole, Alveolus, Inflammation,  |                                                                          |             
           Chronic, Multifocal             |          1                                                               |             
      Bronchiole, Alveolus, Inflammation,  |                                                                          |             
           Chronic Active, Focal           |                            2                                             |             
      Bronchiole, Alveolus, Inflammation,  |                                                                          |             
           Chronic Active, Multifocal      |             3                                3  3              3  3  3   |             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Multifocal, Lymphocyte          |                                                                          |             
      Pleura, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 3| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 6| 3| 5| 3| 2| 3| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|             
                                           | 3| 2| 7| 1| 3| 1| 4| 2| 4| 6| 5| 5| 5| 5| 8| 4| 4| 4| 3| 3| 2| 2| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Inflammation, Chronic Active | 2  3  1  2  1  2  1  2  1  1  2  1  1  2     1  2  2  2  1  2  3  1  4  2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Respiratory Epithelium, Hyperplasia  | 4  4  3  4  3  4  3  3  3  3  3  2  3  3     3  3  2  3  2  3  3  3  3  3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +           +  +  +                 M        +                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +           +  +  +                 +     +  +                     |             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal, Suppurative          |                                                                          |             
      Mineralization, Multifocal           |       2                                                                  |             
      Nephropathy, Chronic                 |                         1                                                |             
      Capsule, Fibrosis, Multifocal        |                                                 2                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +     +     +  +  +  +        +     +        +        +     +  +   |             
      Inflammation, Chronic Active, Diffuse|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 3| 3| 9| 5| 8| 3| 6| 3| 3| 3| 8| 3|            |
                                           | 2| 3| 5| 5| 4| 6| 4| 3| 3| 3| 3| 2| 2| 2| 2| 5| 0| 2| 5| 1| 4| 3| 3| 6| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +                             M              +  +                     |   9        |
      Inflammation, Chronic Active         |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +                             A  A        +  +  +                     |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +                             +              +  +                     |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +                             A              M  +                     |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +                             A              +  +                     |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +                             A              +  +                     |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +                          +  +           +  +  +                     |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +                             A           +  +  M                     |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +                             M              +  +                     |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    M                          +  M              +  +                     |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | A  +     +        +     +        +  +     +  +  +  +     +               |  23        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |    2                                                                     |      1  2.0|
      Necrosis, Acute, Focal               |                                              2  1                        |      3  1.3|
      Necrosis, Acute, Multifocal          |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +                             A              +  +                     |   9        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +                             +              +  +                     |  11        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    1                                                                     |      2  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +                             A              +  +                     |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | A  +                             A              +  +                     |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | A  +                             A              +  +                     |  11        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +                             +              +  +                     |  13        |
      Cardiomyopathy                       |                                                    2                     |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +                             A              +  +                     |  10        |
      Capsule, Hyperplasia, Multifocal     |                                                    1                     |      3  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +                             A              +  +                     |  10        |
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +                             A              +  +                     |   9        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +                             A              +  +                     |   9        |
      Hyperplasia, Multifocal              |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | A  +                             M              +  +                     |   6        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +                             +              +  +                     |  11        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 3| 3| 9| 5| 8| 3| 6| 3| 3| 3| 8| 3|            |
                                           | 2| 3| 5| 5| 4| 6| 4| 3| 3| 3| 3| 2| 2| 2| 2| 5| 0| 2| 5| 1| 4| 3| 3| 6| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | A  +                             M              +  +                     |   9        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | A  +                             +              +  +                     |  11        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +                    A     +        +                        |   6        |
      Abscess                              |                                                 4                        |      1  4.0|
      Cyst                                 |             4                                                            |      1  4.0|
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                        1                                 |      3  1.7|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +                             A              +  +                     |   9        |
      Inflammation, Chronic Active         |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +           +                 +        +     +  +     +               |  17        |
      Dilatation                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | A  +                             +              +  +                    +|  12        |
      Seminiferous Tubule, Atrophy         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +                             +              +  +                     |  10        |
      Myeloid Cell, Hyperplasia            |    4                                                                     |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +  +     +           +  +     +  +  +  +  +     +               |  26        |
      Angiectasis, Focal                   |                                        2                                 |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                    2                     |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +        +     +              +              +  M                     |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +     +  +     +           +  M           +  +  +                     |  19        |
      Hematopoietic Cell Proliferation     |          1                    2              1                           |      4  1.5|
      Hemorrhage                           |          2  2     4           2                                          |     12  2.6|
      Hyperplasia, Lymphoid                |                               2                                          |      1  2.0|
      Hyperplasia                          |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +                    +        A           +  +  +                     |  14        |
      Hematopoietic Cell Proliferation     |    4                    3                    4                           |      6  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    M                             A        +     +  +                     |   6        |
      Depletion Lymphoid                   |                                                 3                        |      1  3.0|
      Inflammation, Acute                  |                                                 2                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 3| 3| 9| 5| 8| 3| 6| 3| 3| 3| 8| 3|            |
                                           | 2| 3| 5| 5| 4| 6| 4| 3| 3| 3| 3| 2| 2| 2| 2| 5| 0| 2| 5| 1| 4| 3| 3| 6| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +                             M              M  M                     |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | A  +           +  +  +  +  +  +  +           +  +  +              +     +|  30        |
      Inflammation, Chronic Active         |                                                    4                     |      1  4.0|
      Ulcer                                |                                                    4                     |      1  4.0|
      Prepuce, Abscess                     |    4                                                                     |      2  4.0|
      Prepuce, Inflammation, Chronic Active|                3                                                         |      1  3.0|
      Prepuce, Ulcer                       |    4                                                                     |      2  4.0|
      Scrotal, Pigmentation, Focal, Melanin|                                                                          |      1  4.0|
      Scrotal, Hair Follicle, Hyperplasia, |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Abscess         |                                                    4                     |      1  4.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +                             +              +  +                     |  10        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                    +                     |   1        |
      Arteriole, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +                             +              +  +                     |  11        |
      Mineralization, Multifocal           |    2                             2              2  2                     |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +                                            +  +                     |   6        |
                                            __________________________________________________________________________|____________|
   Lung                                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                               3                                          |      1  3.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |          1                                                               |      2  1.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Histiocyte                      |                   2                                               1      |      3  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                         1|      2  1.5|
      Alveolus, Inflammation, Chronic      |                                                                          |            |
          Active, Focal                    |                                                                1         |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05070-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:49:27  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 3| 3| 9| 5| 8| 3| 6| 3| 3| 3| 8| 3|            |
                                           | 2| 3| 5| 5| 4| 6| 4| 3| 3| 3| 3| 2| 2| 2| 2| 5| 0| 2| 5| 1| 4| 3| 3| 6| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Bronchiole, Hyperplasia, Focal       |                                                       1                  |      1  1.0|
      Bronchiole, Hyperplasia, Multifocal  |                                                             1            |      4  1.3|
      Bronchiole, Inflammation, Chronic,   |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
      Bronchiole, Alveolus, Inflammation,  |                                                                          |            |
           Chronic, Multifocal             |                                                                          |      1  1.0|
      Bronchiole, Alveolus, Inflammation,  |                                                                          |            |
           Chronic Active, Focal           |                      2                                               1   |      3  1.7|
      Bronchiole, Alveolus, Inflammation,  |                                                                          |            |
           Chronic Active, Multifocal      |       2                 3     3  2        4        1                     |     12  2.8|
      Mediastinum, Infiltration Cellular,  |                                                                          |            |
           Multifocal, Lymphocyte          |                                           2                              |      1  2.0|
      Pleura, Infiltration Cellular,       |                                                                          |            |
          Lymphocyte                       |                                           4                              |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mucosa, Inflammation, Chronic Active |    1  2  2  3  2  3  3  3  2  2     1  2  3  2  1  1  3  2  3  3  4  1  2|     47  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |       2                                                                  |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |    3  3  3  4  3  3  4  3  4  3  3  3  4  3  4  3  3  3  3  4  4  4  3  3|     48  3.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | A  +                             M              +  +                     |   9        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | A  +                             A              +  +                     |  11        |
      Inflammation, Acute, Focal           |                                                 1                        |      1  1.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal, Suppurative          |    4                                                                     |      1  4.0|
      Mineralization, Multifocal           |                                                                          |      1  2.0|
      Nephropathy, Chronic                 |                                                                          |      1  1.0|
      Capsule, Fibrosis, Multifocal        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +     +     +  +           +  A     +  +  +  +  +  +  +        +  +   |  27        |
      Inflammation, Chronic Active, Diffuse|    4                                                                     |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.