National Toxicology Program

National Toxicology Program
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TDMS Study 05070-02 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Midwest Research Inst                                     DATE: 09/09/94   
EXP: 05070                      VINYL TOLUENE                  TIME: 00:18:12   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 56406    
CONT: N01-ES-38042                                             CAS: 25013154    
PATHOLOGIST: M. STEDHAM                                                         
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Midwest Research Inst                                     DATE: 09/09/94  
EXP: 05070                      VINYL TOLUENE                  TIME: 00:18:12  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 56406   
CONT: N01-ES-38042                                             CAS: 25013154   
PATHOLOGIST: M. STEDHAM                                                        

                                   VINYL TOLUENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 731 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 1    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      514   529   567   588   607   644   648   658   670   673                 |
 |      673   687   696   707   714   717                                         |
 |  CENSORED DEATHS                                                               |
 |      266                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 20     CENSORED DEATHS 0    TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      358   392   434   550   553   567   574   582   602   623                 |
 |      623   632   661   676   676   682   686   695   714   724                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 25 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 6      CENSORED DEATHS 3    TERMINAL 41        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      574   664   683   702   703   716                                         |
 |  CENSORED DEATHS                                                               |
 |      148   148   252                                                           |
 |                                                                                |
 ==================================================================================

                                   VINYL TOLUENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 731 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   731 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0 100.0  95.9  91.8  83.7  67.3      |
 |           |                                                                    |
 |           |                                                                    |
 |10 PPM     |   100.0 100.0 100.0  98.0  96.0  94.0  94.0  82.0  74.0  60.0      |
 |           |                                                                    |
 |           |                                                                    |
 |25 PPM     |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  97.9  95.7  87.2      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          10 PPM           25 PPM        |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       67.3%            60.0%            87.2%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.026N         P=0.472          P=0.031N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       643.3            600.2            673.7         |
 |NATURAL DEATHS (C)      |       (16.1)           (23.2)           (21.3)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       693.6            678.7            691.2         |
 |(STANDARD ERROR)        |       (11.6)           (12.9)           (18.8)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                   VINYL TOLUENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 731 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      47    469   560   574   589   672   692   692   700   705                 |
 |      709   714   715   728                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 1    TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      459   582   657   665   679   679   690   693   696   696                 |
 |      714   714                                                                 |
 |  CENSORED DEATHS                                                               |
 |      606                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 25 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 8      CENSORED DEATHS 8    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      350   464   603   616   667   672   674   728                             |
 |  CENSORED DEATHS                                                               |
 |      3     42    148   148   148   148   148   148                             |
 |                                                                                |
 ==================================================================================

                                   VINYL TOLUENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 731 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   731 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |    98.0  98.0  98.0  98.0  98.0  96.0  96.0  90.0  90.0  72.0      |
 |           |                                                                    |
 |           |                                                                    |
 |10 PPM     |   100.0 100.0 100.0 100.0 100.0  98.0  98.0  96.0  91.9  75.6      |
 |           |                                                                    |
 |           |                                                                    |
 |25 PPM     |   100.0 100.0 100.0  97.6  97.6  95.2  95.2  92.9  90.5  81.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          10 PPM           25 PPM        |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       72.0%            75.6%            81.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.434N         P=0.847N         P=0.473N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       611.9            660.3            596.8         |
 |NATURAL DEATHS (C)      |       (48.1)           (20.9)           (44.9)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       697.6            711.5            611.2         |
 |(STANDARD ERROR)        |       (15.2)           ( 6.8)           (32.5)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                           VINYL TOLUENE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        10 PPM           = 2
                                                        25 PPM           = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                        2                       1        3
      |
      |                                                          2    2                  1  1     3              3
      |                                                               2     2               1    1               3  3
   95 +
      |                                                                     2                  2 1  1               3  3
      |
      |                                                                                             1   1
P  90 +                                                                                        2 2      1    1
E     |                                                                                                                3 3
R     |                                                                                          22          11          3  3
C     |                                                                                           2 2         11
E  85 +
N     |                                                                                             2  2       1  1
T     |                                                                                                2  2
      |                                                                                                           11
S  80 +
U     |
R     |                                                                                                   2 2      1 1
V     |                                                                                                     2    2
I  75 +                                                                                                              11
V     |                                                                                                          2 2  11
A     |
L     |                                                                                                                11
   70 +                                                                                                            22   11
      |
      |                                                                                                                  1  1
      |                                                                                                             2 2
   65 +
      |                                                                                                               2 2
      |                                                                                                                 2 2
      |
   60 +                                                                                                                   2 2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 2 obs hidden.

                                                           VINYL TOLUENE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        10 PPM           = 2
                                                        25 PPM           = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1       1                                              3                 2
      |
      |         1                                              3                 21                 2
      |                                                                           1             1   2          2
P  95 +                                                                           3                     3
E     |                                                                                         1 1            2 2
R     |                                                                                           1   1 33       2 2
C     |
E  90 +                                                                                               1  3        1
N     |
T     |                                                                                                           12 1
      |                                                                                                           33
S  85 +
U     |                                                                                                            3 11   3
R     |                                                                                                               11
V     |                                                                                                                   3 3
I  80 +                                                                                                               211
V     |
A     |
L     |                                                                                                                 11
   75 +                                                                                                                 2   2
      |                                                                                                                  11
      |                                                                                                                   1 1
      |
   70 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 8 obs hidden.

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