TDMS Study 05070-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
VINYL TOLUENE
NTP Experiment-Test: 05070-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
Facility: Midwest Research Institute
Chemical CAS #: 25013154
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund Sacrifice 16 21 18
Natural Death 3 1 6
Survivors
Terminal Sacrifice 31 28 26
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (5) (46)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Parasite Metazoan 2 (4%) 8 (17%)
Artery, Inflammation, Chronic, Focal 1 (2%)
Intestine Large, Colon (50) (10) (49)
Parasite Metazoan 7 (14%) 1 (10%) 9 (18%)
Muscularis, Atrophy, Focal 1 (2%)
Intestine Large, Rectum (46) (9) (46)
Parasite Metazoan 2 (4%) 3 (7%)
Mucosa, Inflammation, Chronic Active,
Multifocal 1 (2%)
Intestine Small, Duodenum (50) (9) (50)
Muscularis, Fibrosis, Focal 1 (2%)
Intestine Small, Ileum (48) (7) (48)
Inflammation, Chronic, Diffuse 1 (2%)
Parasite Metazoan 1 (2%)
Liver (50) (33) (50)
Angiectasis, Focal 3 (6%) 3 (6%)
Angiectasis, Multifocal 2 (6%) 1 (2%)
Basophilic Focus 8 (16%) 3 (9%) 7 (14%)
Basophilic Focus, Multiple 19 (38%) 9 (27%) 14 (28%)
Clear Cell Focus 1 (2%)
Congestion, Acute, Multifocal 3 (9%)
Cytomegaly, Multifocal 1 (2%) 1 (2%)
Cytoplasmic Alteration, Focal 1 (2%) 1 (2%)
Eosinophilic Focus 1 (2%)
Fatty Change, Diffuse 3 (6%) 1 (3%)
Fatty Change, Focal 2 (4%)
Fatty Change, Multifocal 7 (14%) 1 (3%) 4 (8%)
Fibrosis, Multifocal 1 (2%)
Granuloma, Multifocal 19 (38%) 6 (18%) 14 (28%)
Hemorrhage, Acute, Multifocal 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%) 5 (15%) 6 (12%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatodiaphragmatic Nodule, Multiple 1 (2%) 1 (3%)
Hyperplasia, Focal, Nodular 2 (6%)
Hyperplasia, Multifocal, Nodular 1 (2%) 2 (4%)
Inflammation, Chronic, Multifocal 1 (2%)
Mitotic Alteration 1 (3%) 1 (2%)
Mixed Cell Focus 1 (2%) 3 (6%)
Mixed Cell Focus, Two 1 (2%)
Necrosis, Focal 1 (2%) 1 (3%)
Necrosis, Multifocal 8 (16%) 1 (3%) 5 (10%)
Pigmentation, Multifocal 1 (3%)
Bile Duct, Hyperplasia, Focal 1 (2%)
Bile Duct, Hyperplasia, Multifocal 6 (12%) 7 (21%) 6 (12%)
Centrilobular, Atrophy, Multifocal 1 (2%) 1 (3%)
Centrilobular, Degeneration, Diffuse 1 (2%) 4 (12%)
Centrilobular, Degeneration, Multifocal 1 (3%)
Centrilobular, Fatty Change, Diffuse 4 (8%) 3 (9%) 5 (10%)
Centrilobular, Fatty Change, Multifocal 1 (2%)
Centrilobular, Necrosis, Diffuse 1 (2%)
Centrilobular, Necrosis, Multifocal 1 (2%) 3 (6%)
Periportal, Fatty Change, Multifocal 2 (6%)
Portal, Inflammation, Chronic, Multifocal 1 (2%)
Mesentery (4) (2) (5)
Artery, Inflammation, Multifocal, Necrotizing 1 (20%)
Fat, Inflammation, Focal, Necrotizing 1 (20%)
Fat, Necrosis, Focal 1 (25%) 4 (80%)
Pancreas (50) (13) (49)
Inflammation, Focal, Granulomatous 1 (2%)
Acinus, Atrophy, Diffuse 2 (4%)
Acinus, Atrophy, Focal 1 (2%) 2 (4%)
Acinus, Atrophy, Multifocal 13 (26%) 3 (23%) 8 (16%)
Acinus, Hyperplasia, Focal 1 (2%)
Artery, Inflammation, Chronic, Focal 2 (4%)
Artery, Inflammation, Chronic Active,
Multifocal 1 (2%)
Duct, Cyst, Multiple 1 (2%)
Interlobular, Inflammation, Chronic, Diffuse 1 (2%)
Pharynx (1)
Mucosa, Palate, Inflammation, Chronic,
Diffuse 1 (100%)
Salivary Glands (50) (9) (47)
Inflammation, Chronic, Diffuse 1 (2%)
Inflammation, Chronic Active, Focal 1 (2%)
Duct, Inflammation, Chronic Active, Focal 1 (2%)
Parotid Gland, Inflammation, Chronic Active,
Focal 1 (2%)
Stomach, Forestomach (49) (11) (49)
Inflammation, Chronic Active 3 (6%) 1 (9%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Ulcer, Single, Subacute 1 (2%)
Epithelium, Hyperplasia 2 (4%) 1 (9%) 1 (2%)
Stomach, Glandular (50) (11) (50)
Cyst Epithelial Inclusion 1 (9%)
Inflammation, Chronic Active 1 (2%)
Mucosa, Cyst, Multiple 2 (4%)
Tooth (1)
Peridontal Tissue, Inflammation, Chronic,
Diffuse 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10) (50)
Abscess, Single 1 (2%)
Cardiomyopathy 36 (72%) 4 (40%) 40 (80%)
Artery, Inflammation, Chronic Active, Focal 1 (2%)
Artery, Inflammation, Chronic Active,
Multifocal 1 (2%)
Atrium Left, Thrombosis 2 (4%) 1 (10%) 2 (4%)
Epicardium, Inflammation, Chronic Active,
Focal 1 (2%)
Myocardium, Degeneration, Focal 1 (2%)
Valve, Degeneration, Mucoid, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (14) (50)
Bilateral, Capsule, Fibrosis, Multifocal 1 (2%)
Capsule, Accessory Adrenal Cortical Nodule 5 (10%) 1 (7%) 5 (10%)
Adrenal Gland, Cortex (50) (14) (50)
Angiectasis, Focal 2 (4%)
Angiectasis, Multifocal 4 (8%) 3 (21%) 4 (8%)
Atrophy 1 (2%)
Congestion 4 (8%) 1 (7%) 2 (4%)
Degeneration, Diffuse, Fatty 1 (2%) 1 (2%)
Degeneration, Fatty, Focal 8 (16%) 1 (7%) 8 (16%)
Degeneration, Fatty, Multifocal 2 (4%) 1 (7%) 1 (2%)
Hyperplasia, Focal 9 (18%) 2 (4%)
Hyperplasia, Multifocal 1 (7%) 1 (2%)
Hypertrophy, Focal 4 (8%) 1 (2%)
Hypertrophy, Multifocal 2 (4%) 1 (7%) 1 (2%)
Pigmentation, Diffuse, Hemosiderin 2 (4%) 1 (2%)
Pigmentation, Hemosiderin, Multifocal 1 (2%)
Adrenal Gland, Medulla (48) (14) (45)
Angiectasis, Multifocal 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia, Focal 5 (10%) 1 (7%) 5 (11%)
Hyperplasia, Multifocal 2 (4%) 3 (7%)
Vacuolization Cytoplasmic, Diffuse 1 (2%)
Islets, Pancreatic (50) (12) (49)
Ectopic Tissue, Focal 1 (2%)
Hyperplasia, Focal 4 (8%)
Hyperplasia, Multifocal 2 (4%)
Hypertrophy, Focal 2 (4%) 1 (2%)
Hypoplasia, Diffuse 1 (2%)
Pituitary Gland (50) (43) (50)
Pars Distalis, Angiectasis, Focal 4 (8%) 1 (2%) 2 (4%)
Pars Distalis, Angiectasis, Multifocal 2 (4%) 3 (7%)
Pars Distalis, Concretion 1 (2%)
Pars Distalis, Cyst 5 (10%) 10 (23%) 10 (20%)
Pars Distalis, Cyst, Multiple 1 (2%)
Pars Distalis, Hemorrhage, Chronic, Focal 1 (2%)
Pars Distalis, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 3 (6%) 2 (5%) 2 (4%)
Pars Distalis, Hyperplasia, Multifocal 1 (2%) 1 (2%)
Pars Distalis, Pigmentation, Diffuse,
Hemosiderin 1 (2%)
Pars Intermedia, Pigmentation, Diffuse,
Hemosiderin 1 (2%)
Pars Nervosa, Pigmentation, Diffuse 1 (2%)
Thyroid Gland (50) (10) (50)
Cyst 2 (4%) 1 (2%)
Developmental Malformation 1 (10%)
C-Cell, Hyperplasia, Focal 2 (4%) 3 (6%)
C-Cell, Hyperplasia, Multifocal 21 (42%) 1 (10%) 7 (14%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Necrosis, Acute 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (11) (46)
Abscess 1 (9%)
Atrophy 1 (9%) 1 (2%)
Ectasia 2 (18%) 4 (9%)
Hyperplasia 3 (6%) 1 (9%) 3 (7%)
Inflammation, Acute 2 (4%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (9%) 2 (4%)
Inflammation, Granulomatous 2 (4%) 3 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Ovary (50) (18) (50)
Angiectasis, Multifocal 1 (2%)
Congestion, Diffuse 1 (2%) 1 (2%)
Cyst 5 (28%) 3 (6%)
Hyperplasia 1 (2%)
Uterus (50) (18) (50)
Adenomyosis, Focal 1 (2%)
Cyst 1 (2%) 1 (2%)
Dilatation 1 (2%) 3 (17%) 2 (4%)
Inflammation, Acute, Multifocal 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Endometrium, Hyperplasia, Focal 1 (2%)
Epithelium, Hyperplasia, Diffuse 1 (2%) 1 (2%)
Epithelium, Hyperplasia, Focal 2 (4%) 1 (2%)
Lumen, Hemorrhage 1 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (9) (50)
Hyperplasia 2 (4%) 3 (6%)
Hyperplasia, Megakaryocyte 1 (2%)
Metaplasia, Diffuse, Osseous 1 (2%)
Myeloid Cell, Hyperplasia 6 (12%) 2 (4%)
Lymph Node (50) (17) (50)
Hyperplasia, Re Cell 1 (2%)
Mediastinal, Hemorrhage 4 (8%) 3 (6%)
Mediastinal, Hyperplasia, Re Cell 1 (2%)
Mediastinal, Pigmentation, Diffuse,
Hemosiderin 1 (2%)
Pancreatic, Hemorrhage 1 (2%) 1 (6%)
Pancreatic, Inflammation, Acute 1 (6%)
Pancreatic, Pigmentation, Hemosiderin 1 (2%)
Renal, Hyperplasia, Plasma Cell 1 (2%)
Renal, Hyperplasia, Re Cell 1 (2%)
Lymph Node, Mandibular (47) (11) (47)
Edema 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Plasma Cell 2 (4%) 5 (11%)
Hyperplasia, Re Cell 1 (9%) 1 (2%)
Artery, Inflammation, Chronic Active, Focal 1 (2%)
Lymph Node, Mesenteric (47) (12) (46)
Hemorrhage 3 (6%) 3 (25%) 2 (4%)
Hyperplasia, Plasma Cell 1 (2%)
Hyperplasia, Re Cell 4 (9%) 3 (7%)
Pigmentation, Hemosiderin 1 (8%)
Spleen (50) (19) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Fibrosis, Focal 1 (5%) 2 (4%)
Fibrosis, Multifocal 1 (2%)
Granuloma, Multifocal 1 (2%)
Hematopoietic Cell Proliferation 5 (10%) 5 (10%)
Hyperplasia, Multifocal, Reticulum Cell 1 (2%)
Metaplasia, Focal, Osseous 1 (5%)
Pigmentation, Hemosiderin 11 (22%) 1 (5%) 15 (30%)
Capsule, Ectopic Tissue 1 (2%)
Capsule, Infiltration Cellular, Multifocal,
Lymphocyte 1 (2%)
Thymus (38) (6) (37)
Ectopic Parathyroid Gland 1 (3%) 2 (33%)
Hyperplasia, Diffuse, Tubular 6 (16%) 14 (38%)
Infiltration Cellular, Polymorphonuclear 1 (3%)
Artery, Mediastinum, Inflammation, Chronic
Active, Multifocal 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (29) (49)
Ectasia, Diffuse 3 (10%) 1 (2%)
Ectasia, Focal 2 (4%) 2 (4%)
Ectasia, Multifocal 12 (25%) 10 (34%) 15 (31%)
Galactocele 1 (3%)
Hyperplasia, Diffuse 14 (29%) 11 (38%) 15 (31%)
Hyperplasia, Focal 1 (2%) 1 (3%) 2 (4%)
Hyperplasia, Multifocal 4 (8%)
Inflammation, Granulomatous, Multifocal 2 (4%)
Artery, Inflammation, Chronic Active, Focal 1 (2%)
Skin (50) (13) (50)
Hyperplasia, Focal, Squamous 1 (2%)
Inflammation, Chronic Active, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (9) (50)
Hyperostosis 1 (2%) 2 (4%)
Osteopetrosis 1 (2%) 5 (10%)
Skeletal Muscle (1)
Inflammation, Diffuse, Proliferative 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (11) (50)
Compression 11 (22%) 1 (9%) 16 (32%)
Hemorrhage, Focal 2 (4%)
Hemorrhage, Multifocal 1 (2%) 1 (9%)
Hydrocephalus 2 (4%) 1 (9%) 5 (10%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (46) (6) (40)
Hyperplasia, Focal, Papillary 1 (3%)
Inflammation, Acute, Diffuse 1 (3%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Chronic, Diffuse 1 (2%)
Inflammation, Chronic, Focal 4 (9%) 3 (8%)
Inflammation, Chronic Active, Focal 10 (22%) 4 (10%)
Submucosa, Dilatation, Multifocal 1 (2%)
Lung (50) (50) (50)
Atelectasis, Focal 1 (2%)
Autolysis 1 (2%)
Granuloma, Multifocal 1 (2%)
Hemorrhage, Acute, Multifocal 1 (2%)
Inflammation, Chronic, Multifocal 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 5 (10%) 1 (2%)
Alveolar Epithelium, Hyperplasia, Multifocal 1 (2%)
Alveolus, Infiltration Cellular, Focal,
Histiocyte 1 (2%)
Bronchiole, Alveolus, Inflammation, Acute,
Multifocal 1 (2%)
Interstitium, Inflammation, Chronic, Focal 2 (4%)
Interstitium, Inflammation, Chronic,
Multifocal 1 (2%) 1 (2%) 1 (2%)
Peribronchial, Hyperplasia, Lymphoid,
Multifocal 2 (4%)
Pleura, Inflammation, Multifocal, Subacute 1 (2%)
Nose (50) (49) (50)
Lumen, Exudate 1 (2%) 4 (8%) 2 (4%)
Lumen, Foreign Body 2 (4%) 1 (2%)
Mucosa, Inflammation, Acute 1 (2%)
Mucosa, Inflammation, Chronic 2 (4%) 2 (4%) 1 (2%)
Mucosa, Inflammation, Chronic Active 1 (2%) 4 (8%) 4 (8%)
Mucosa, Metaplasia, Focal 1 (2%)
Mucosa, Thrombosis, Multifocal 2 (4%) 4 (8%)
Nasolacrimal Duct, Exudate 5 (10%) 3 (6%) 4 (8%)
Nasolacrimal Duct, Inflammation, Chronic 13 (26%) 17 (35%) 16 (32%)
Nasolacrimal Duct, Inflammation, Chronic
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Active 5 (10%) 1 (2%) 4 (8%)
Olfactory Epithelium, Atrophy 2 (4%) 3 (6%)
Olfactory Epithelium, Cyst 5 (10%) 13 (26%)
Olfactory Epithelium, Erosion 3 (6%) 4 (8%)
Olfactory Epithelium, Exudate 1 (2%)
Olfactory Epithelium, Hyperplasia, Eosinophil 2 (4%) 9 (18%) 21 (42%)
Olfactory Epithelium, Metaplasia 1 (2%)
Respiratory Epithelium, Cyst 6 (12%) 10 (20%)
Respiratory Epithelium, Hyperplasia 7 (14%) 19 (39%) 16 (32%)
Respiratory Epithelium, Hyperplasia,
Eosinophil 3 (6%)
Respiratory Epithelium, Hyperplasia,
Multifocal 1 (2%)
Trachea (50) (8) (50)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (3) (5)
Cataract 1 (50%) 1 (20%)
Bilateral, Cataract 1 (33%) 1 (20%)
Bilateral, Retina, Degeneration 1 (33%)
Retina, Degeneration 1 (50%) 1 (20%)
Harderian Gland (2)
Inflammation, Chronic, Multifocal 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (14) (50)
Hydronephrosis 1 (2%)
Nephropathy, Chronic 46 (92%) 6 (43%) 43 (86%)
Pigmentation, Diffuse 8 (16%) 2 (14%) 11 (22%)
Pigmentation, Multifocal 11 (22%) 1 (7%) 6 (12%)
Bilateral, Hydronephrosis 1 (2%)
Cortex, Cyst 1 (2%)
Cortex, Hyperplasia, Atypical, Focal 2 (4%) 1 (2%)
Cortex, Inflammation, Focal, Suppurative 1 (2%)
Cortex, Mineralization, Multifocal 1 (2%)
Corticomedullary Junction, Mineralization,
Multifocal 1 (2%)
Pelvis, Inflammation, Diffuse, Suppurative 1 (2%)
Proximal Convoluted Renal Tubule, Necrosis,
Multifocal 2 (4%)
Transitional Epithelium, Hyperplasia 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Mineralization,
Focal 1 (2%) 1 (2%)
Transitional Epithelium, Mineralization,
Multifocal 3 (6%) 3 (6%)
Urinary Bladder (49) (9) (46)
Ectasia 2 (4%)
Inflammation, Chronic, Diffuse 1 (2%)
Artery, Inflammation, Chronic Active,
Multifocal 1 (2%)
Transitional Epithelium, Hyperplasia, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund Sacrifice 24 29 28
Natural Death 6 4 3
Survivors
Terminal Sacrifice 19 17 19
Wrong Sex 1
Animals Examined Microscopically 49 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (43) (9) (47)
Hyperplasia, Lymphoid 1 (2%)
Parasite Metazoan 2 (5%) 4 (9%)
Intestine Large, Colon (46) (13) (49)
Hyperplasia, Lymphoid 1 (2%)
Mineralization, Multifocal 1 (2%)
Parasite Metazoan 4 (9%) 6 (12%)
Artery, Inflammation, Chronic Active, Focal 1 (2%)
Intestine Large, Rectum (36) (12) (40)
Parasite Metazoan 2 (6%) 2 (5%)
Artery, Submucosa, Inflammation, Chronic
Active, Multifocal 1 (3%)
Intestine Small, Duodenum (45) (14) (48)
Inflammation, Acute, Multifocal 1 (7%)
Inflammation, Chronic, Diffuse 1 (2%)
Ulcer, Two 1 (2%)
Intestine Small, Ileum (44) (12) (44)
Inflammation, Chronic Active, Multifocal 1 (2%)
Liver (49) (42) (50)
Angiectasis, Focal 3 (6%) 3 (7%) 2 (4%)
Angiectasis, Multifocal 3 (6%) 3 (6%)
Basophilic Focus 1 (2%) 4 (10%) 3 (6%)
Basophilic Focus, Multiple 1 (2%) 3 (7%) 1 (2%)
Congestion 2 (5%)
Cytomegaly, Focal 1 (2%)
Cytomegaly, Multifocal 1 (2%)
Cytoplasmic Alteration, Focal 2 (4%) 1 (2%)
Degeneration, Ballooning, Focal 3 (6%) 3 (6%)
Eosinophilic Focus 1 (2%) 1 (2%) 1 (2%)
Eosinophilic Focus, Multiple 1 (2%)
Fatty Change, Diffuse 1 (2%) 3 (7%) 1 (2%)
Fatty Change, Focal 2 (4%) 1 (2%)
Fatty Change, Multifocal 1 (2%) 3 (7%) 8 (16%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Granuloma, Multifocal 4 (8%) 4 (8%)
Hematopoietic Cell Proliferation, Multifocal 1 (2%)
Hemorrhage, Multifocal 2 (4%) 1 (2%)
Hepatodiaphragmatic Nodule 3 (6%) 3 (7%) 3 (6%)
Hepatodiaphragmatic Nodule, Multiple 1 (2%)
Hyperplasia, Focal, Nodular 1 (2%)
Hyperplasia, Multifocal, Nodular 1 (2%)
Mitotic Alteration 2 (5%)
Necrosis, Focal 1 (2%) 1 (2%)
Necrosis, Multifocal 12 (24%) 3 (7%) 8 (16%)
Pigmentation, Multifocal 1 (2%)
Thrombosis, Two 1 (2%)
Vacuolization Cytoplasmic, Multifocal 1 (2%)
Bile Duct, Fibrosis, Multifocal 2 (4%) 1 (2%)
Bile Duct, Hyperplasia, Multifocal 32 (65%) 23 (55%) 30 (60%)
Centrilobular, Congestion, Diffuse 1 (2%)
Centrilobular, Degeneration, Diffuse 2 (4%) 5 (12%) 1 (2%)
Centrilobular, Degeneration, Multifocal 4 (8%)
Centrilobular, Fatty Change, Diffuse 11 (22%) 2 (5%) 4 (8%)
Centrilobular, Fatty Change, Multifocal 1 (2%)
Centrilobular, Necrosis, Diffuse 5 (10%)
Centrilobular, Necrosis, Multifocal 1 (2%) 1 (2%)
Periportal, Cytomegaly, Diffuse 1 (2%)
Periportal, Fatty Change, Diffuse 1 (2%) 1 (2%) 2 (4%)
Portal, Fibrosis, Multifocal 1 (2%)
Portal, Inflammation, Chronic, Multifocal 1 (2%)
Portal, Inflammation, Chronic Active,
Multifocal 2 (4%) 1 (2%)
Mesentery (8) (4) (6)
Accessory Spleen, Two 1 (17%)
Hemorrhage, Acute, Multifocal 1 (13%)
Inflammation, Chronic Active, Multifocal 1 (17%)
Artery, Ectasia, Multifocal 1 (25%)
Artery, Inflammation, Chronic, Focal 1 (17%)
Artery, Inflammation, Chronic, Multifocal 1 (13%) 1 (25%)
Artery, Mineralization, Multifocal 1 (25%) 1 (17%)
Fat, Necrosis, Focal 1 (25%)
Pancreas (46) (19) (49)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 2 (4%)
Acinus, Atrophy, Diffuse 3 (7%) 1 (5%)
Acinus, Atrophy, Focal 5 (11%) 2 (4%)
Acinus, Atrophy, Multifocal 18 (39%) 2 (11%) 20 (41%)
Acinus, Hyperplasia, Focal 1 (2%)
Acinus, Hyperplasia, Multifocal 1 (2%)
Artery, Ectasia, Multifocal 1 (5%)
Artery, Fibrosis 1 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Artery, Inflammation, Chronic, Multifocal 1 (5%)
Artery, Inflammation, Chronic Active, Focal 2 (4%)
Artery, Inflammation, Chronic Active,
Multifocal 2 (4%) 1 (2%)
Artery, Mineralization, Multifocal 1 (5%)
Pharynx (1) (1) (1)
Inflammation, Chronic Active, Multifocal 1 (100%)
Palate, Inflammation, Chronic, Focal 1 (100%) 1 (100%)
Salivary Glands (48) (18) (50)
Artery, Inflammation, Chronic Active,
Multifocal 1 (2%)
Stomach, Forestomach (48) (13) (49)
Inflammation, Chronic Active 5 (10%) 2 (15%) 5 (10%)
Mineralization, Diffuse 1 (2%)
Ulcer 3 (6%) 1 (8%) 3 (6%)
Epithelium, Hyperplasia 6 (13%) 2 (15%) 6 (12%)
Submucosa, Edema, Diffuse 1 (2%)
Submucosa, Inflammation, Subacute 1 (2%)
Stomach, Glandular (47) (14) (50)
Cyst, Multiple 1 (2%)
Infiltration Cellular, Lymphocyte 1 (7%)
Inflammation, Chronic Active, Focal 1 (2%)
Mineralization, Diffuse 1 (2%)
Mineralization, Multifocal 1 (2%)
Ulcer, Acute 2 (4%)
Tooth (2) (3) (1)
Dysplasia 3 (100%)
Pulp, Angiectasis 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (14) (50)
Cardiomyopathy 42 (86%) 10 (71%) 40 (80%)
Mineralization, Multifocal 1 (2%)
Atrium Left, Thrombosis 4 (8%) 1 (7%) 2 (4%)
Endocardium, Atrium, Fibrosis, Focal 1 (2%)
Myocardium, Fibrosis, Focal 1 (2%)
Valve, Fibrosis, Focal 1 (2%) 1 (2%)
Valve, Inflammation, Focal, Proliferative 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (24) (50)
Capsule, Accessory Adrenal Cortical Nodule 5 (10%) 2 (8%) 4 (8%)
Adrenal Gland, Cortex (49) (20) (50)
Cytoplasmic Alteration, Focal 1 (2%) 1 (2%)
Degeneration, Diffuse, Fatty 13 (27%) 5 (25%) 9 (18%)
Degeneration, Fatty, Focal 6 (12%) 4 (20%) 6 (12%)
Degeneration, Fatty, Multifocal 3 (6%) 1 (5%) 3 (6%)
Hyperplasia, Focal 4 (8%) 2 (10%) 10 (20%)
Hyperplasia, Multifocal 3 (6%) 2 (4%)
Hypertrophy, Focal 2 (10%) 1 (2%)
Hypertrophy, Multifocal 1 (2%)
Adrenal Gland, Medulla (49) (21) (46)
Angiectasis, Focal 1 (2%)
Hyperplasia, Focal 8 (16%) 3 (14%) 5 (11%)
Hyperplasia, Multifocal 10 (20%) 2 (10%) 4 (9%)
Islets, Pancreatic (46) (16) (49)
Atrophy, Diffuse 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Focal 2 (4%) 2 (4%)
Hyperplasia, Multifocal 1 (2%) 2 (13%) 5 (10%)
Inflammation, Multifocal 1 (2%)
Parathyroid Gland (45) (14) (45)
Hyperplasia 1 (2%) 2 (14%) 5 (11%)
Pituitary Gland (49) (35) (50)
Pars Distalis, Angiectasis 2 (4%) 1 (3%) 3 (6%)
Pars Distalis, Cyst 1 (2%) 4 (11%) 5 (10%)
Pars Distalis, Degeneration, Fatty, Focal 1 (2%)
Pars Distalis, Hyperplasia 1 (3%) 2 (4%)
Pars Distalis, Hyperplasia, Diffuse,
Eosinophil 1 (2%)
Pars Distalis, Hyperplasia, Focal 2 (4%) 3 (9%) 7 (14%)
Pars Distalis, Hyperplasia, Multifocal 5 (10%)
Pars Distalis, Pigmentation, Focal 1 (2%)
Pars Intermedia, Hyperplasia 2 (4%)
Thyroid Gland (49) (20) (50)
Cyst 1 (2%)
Mineralization, Multifocal 1 (2%)
C-Cell, Hyperplasia, Focal 4 (8%) 1 (5%) 2 (4%)
C-Cell, Hyperplasia, Multifocal 4 (8%) 1 (5%) 3 (6%)
Follicle, Cyst 2 (4%)
Follicular Cell, Degeneration, Multifocal 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Necrosis, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (47) (16) (50)
Dilatation, Multifocal 2 (4%) 1 (2%)
Granuloma Sperm, Single 1 (2%) 1 (2%)
Inflammation, Focal, Suppurative 1 (2%)
Left, Atrophy 1 (2%)
Preputial Gland (46) (18) (48)
Abscess 2 (11%)
Atrophy, Diffuse 1 (2%)
Ectasia 2 (4%) 2 (11%) 3 (6%)
Fibrosis, Diffuse 2 (4%)
Inflammation, Chronic Active 4 (9%) 4 (8%)
Inflammation, Diffuse, Granulomatous 1 (2%) 1 (2%)
Inflammation, Focal, Granulomatous 4 (9%) 3 (6%)
Inflammation, Focal, Suppurative 1 (2%)
Inflammation, Granulomatous, Multifocal 18 (39%) 4 (22%) 22 (46%)
Prostate (49) (18) (49)
Hyperplasia, Focal 5 (10%) 5 (10%)
Hyperplasia, Multifocal 3 (6%) 2 (11%) 6 (12%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 8 (16%) 6 (33%) 13 (27%)
Seminal Vesicle (41) (13) (43)
Atrophy, Diffuse 3 (7%) 5 (12%)
Fibrosis, Multifocal 1 (2%)
Inflammation, Chronic Active, Diffuse,
Suppurative 1 (2%)
Inflammation, Diffuse, Subacute 1 (2%)
Testes (49) (42) (50)
Hemorrhage 1 (2%)
Mineralization, Focal 1 (2%)
Mineralization, Multifocal 1 (2%) 1 (2%) 1 (2%)
Arteriole, Inflammation 6 (12%) 2 (5%) 4 (8%)
Capsule, Hyperplasia, Multifocal 1 (2%)
Interstitial Cell, Hyperplasia 2 (4%) 4 (10%) 2 (4%)
Seminiferous Tubule, Atrophy 13 (27%) 11 (26%) 13 (26%)
Seminiferous Tubule, Degeneration 2 (4%) 4 (8%)
Serosa, Necrosis, Focal 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (15) (50)
Atrophy 1 (7%)
Hyperplasia 8 (17%) 2 (13%) 5 (10%)
Metaplasia, Osseous 1 (2%) 1 (7%)
Myelofibrosis 1 (2%)
Myeloid Cell, Hyperplasia 4 (8%) 4 (8%)
Lymph Node (49) (27) (50)
Inflammation, Focal, Suppurative 1 (2%)
Lumbar, Hemorrhage 1 (2%)
Lumbar, Inflammation, Granulomatous,
Multifocal 1 (2%)
Mediastinal, Hemorrhage 2 (4%) 2 (7%) 5 (10%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Hyperplasia, Re Cell 1 (2%)
Mediastinal, Pigmentation, Hemosiderin 2 (4%)
Pancreatic, Hemorrhage 1 (4%)
Pancreatic, Hyperplasia, Lymphoid 2 (4%)
Lymph Node, Mandibular (44) (14) (48)
Hemorrhage 1 (7%) 1 (2%)
Hyperplasia, Lymphoid 2 (5%) 3 (6%)
Hyperplasia, Plasma Cell 2 (5%) 1 (7%) 5 (10%)
Hyperplasia, Re Cell 1 (2%)
Inflammation, Focal, Subacute 1 (2%)
Lymph Node, Mesenteric (44) (17) (48)
Depletion Lymphoid 1 (2%) 1 (2%)
Fibrosis, Multifocal 1 (2%)
Hemorrhage 2 (12%) 2 (4%)
Hyperplasia, Lymphoid 2 (5%) 2 (4%)
Hyperplasia, Re Cell 1 (2%) 3 (6%)
Spleen (49) (35) (49)
Congestion 1 (3%) 1 (2%)
Depletion Lymphoid 1 (2%)
Fibrosis, Focal 1 (2%) 2 (6%) 4 (8%)
Fibrosis, Multifocal 2 (4%) 2 (6%)
Hematopoietic Cell Proliferation 4 (8%) 2 (6%)
Necrosis, Coagulative, Focal 1 (2%)
Pigmentation, Hemosiderin 3 (6%) 1 (3%) 7 (14%)
Thrombosis, Single 1 (2%)
Capsule, Fibrosis, Focal 1 (2%)
Capsule, Fibrosis, Multifocal 1 (2%) 1 (2%)
Thymus (38) (14) (38)
Angiectasis, Multifocal 1 (7%)
Depletion Lymphoid 1 (3%)
Hemorrhage 1 (3%) 1 (7%)
Hyperplasia, Tubular 8 (21%) 2 (14%) 6 (16%)
Artery, Inflammation, Chronic Active 1 (3%) 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (38) (20) (46)
Ectasia, Diffuse 9 (24%) 4 (20%) 4 (9%)
Ectasia, Multifocal 14 (37%) 7 (35%) 6 (13%)
Granuloma 1 (2%)
Hyperplasia, Diffuse 3 (8%) 2 (10%) 7 (15%)
Hyperplasia, Focal 1 (2%)
Inflammation, Chronic Active, Multifocal 2 (5%)
Inflammation, Granulomatous 1 (5%)
Inflammation, Proliferative 2 (5%)
Skin (49) (23) (50)
Cyst Epithelial Inclusion 1 (2%) 3 (13%)
Hyperkeratosis 1 (2%) 2 (9%)
Hyperplasia, Squamous 1 (2%) 1 (4%)
Inflammation, Chronic, Focal 1 (2%) 1 (2%)
Ulcer 1 (2%)
Artery, Subcutaneous Tissue, Inflammation,
Chronic Active, Focal 1 (2%)
Subcutaneous Tissue, Cyst 1 (2%)
Subcutaneous Tissue, Hemorrhage, Chronic,
Focal 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 2 (9%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (18) (50)
Fibrous Osteodystrophy 3 (17%) 2 (4%)
Osteopetrosis 1 (2%)
Sternum, Developmental Malformation 1 (2%)
Skeletal Muscle (2) (4) (1)
Hemorrhage, Acute 2 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (15) (50)
Compression 11 (22%) 5 (33%) 9 (18%)
Hemorrhage, Focal 4 (8%) 1 (2%)
Hemorrhage, Multifocal 1 (2%) 2 (4%)
Hydrocephalus 3 (6%) 2 (13%) 8 (16%)
Perivascular, Infiltration Cellular,
Multifocal, Mixed Cell 1 (7%)
Thalamus, Gliosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (37) (5) (41)
Inflammation, Chronic, Multifocal 2 (5%)
Inflammation, Chronic Active, Focal 7 (19%) 1 (20%) 5 (12%)
Inflammation, Focal, Suppurative 1 (3%)
Submucosa, Dilatation 1 (2%)
Lung (49) (50) (50)
Edema, Focal 1 (2%)
Hemorrhage, Multifocal, Subacute 1 (2%) 1 (2%)
Mineralization, Multifocal 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%)
Alveolar Epithelium, Hyperplasia, Multifocal 2 (4%)
Artery, Mineralization, Focal 1 (2%)
Bronchus, Hyperplasia, Focal, Lymphoid 1 (2%)
Bronchus, Epithelium, Hyperplasia, Focal 1 (2%)
Interstitium, Inflammation, Acute, Multifocal 1 (2%)
Interstitium, Inflammation, Chronic, Diffuse 1 (2%)
Interstitium, Inflammation, Chronic, Focal 1 (2%)
Interstitium, Inflammation, Chronic,
Multifocal 2 (4%) 4 (8%) 2 (4%)
Interstitium, Inflammation, Chronic Active,
Multifocal 2 (4%)
Interstitium, Mineralization, Multifocal 1 (2%)
Vein, Mineralization, Multifocal 1 (2%)
Nose (48) (50) (50)
Lumen, Exudate 2 (4%) 5 (10%) 2 (4%)
Lumen, Foreign Body 2 (4%) 5 (10%) 4 (8%)
Mucosa, Inflammation, Chronic 4 (8%) 4 (8%) 6 (12%)
Mucosa, Inflammation, Chronic Active 2 (4%) 9 (18%) 4 (8%)
Mucosa, Thrombosis, Multifocal 5 (10%) 5 (10%) 3 (6%)
Nasolacrimal Duct, Exudate 1 (2%) 3 (6%) 3 (6%)
Nasolacrimal Duct, Fungus 1 (2%)
Nasolacrimal Duct, Hyperplasia 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic 14 (29%) 16 (32%) 10 (20%)
Nasolacrimal Duct, Inflammation, Chronic
Active 5 (10%) 1 (2%) 5 (10%)
Olfactory Epithelium, Atrophy 2 (4%) 1 (2%) 3 (6%)
Olfactory Epithelium, Cyst 4 (8%) 6 (12%)
Olfactory Epithelium, Erosion 8 (16%) 1 (2%)
Olfactory Epithelium, Hyperplasia, Eosinophil 1 (2%)
Olfactory Epithelium, Inflammation, Chronic
Active 1 (2%)
Olfactory Epithelium, Metaplasia 6 (12%) 4 (8%)
Respiratory Epithelium, Cyst 2 (4%) 13 (26%) 9 (18%)
Respiratory Epithelium, Hyperplasia 8 (17%) 24 (48%) 27 (54%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Respiratory Epithelium, Hyperplasia,
Eosinophil 4 (8%) 1 (2%)
Respiratory Epithelium, Hyperplasia,
Papillary 5 (10%) 2 (4%)
Trachea (48) (14) (50)
Inflammation, Chronic 1 (7%) 2 (4%)
Artery, Inflammation, Chronic Active, Focal 1 (2%)
Glands, Metaplasia, Focal, Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (2) (5)
Anterior, Synechia 1 (50%)
Choroid, Left, Hemorrhage 1 (33%)
Cornea, Inflammation, Chronic Active 1 (50%)
Lens, Right, Cataract 1 (50%)
Retina, Degeneration 1 (33%) 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (35) (50)
Bacterium 1 (3%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (3%)
Inflammation, Acute, Multifocal, Suppurative 1 (3%)
Inflammation, Focal, Suppurative 1 (2%)
Mineralization, Diffuse 1 (2%)
Nephropathy, Chronic 46 (94%) 32 (91%) 48 (96%)
Pigmentation, Diffuse 8 (16%) 2 (6%) 5 (10%)
Pigmentation, Multifocal 2 (4%) 1 (3%) 1 (2%)
Artery, Inflammation, Chronic Active, Focal 1 (2%)
Cortex, Cyst 1 (2%) 1 (3%) 3 (6%)
Cortex, Hyperplasia, Atypical 1 (2%) 2 (4%)
Proximal Convoluted Renal Tubule, Necrosis,
Acute, Multifocal 1 (2%)
Transitional Epithelium, Hyperplasia 2 (4%)
Transitional Epithelium, Mineralization 4 (8%)
Urinary Bladder (48) (12) (49)
Calculus Gross Observation 1 (2%)
Ectasia 1 (2%)
Inflammation, Chronic Active, Focal 1 (2%)
Inflammation, Diffuse, Subacute 1 (2%)
Lumen, Calculus Micro Observation Only,
Single 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Subserosa, Mineralization, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 20
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