National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2067

TDMS Study 05070-01 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Midwest Research Inst                                    VINYL TOLUENE                                    DATE: 09/08/94       
EXPERIMENT: 05070 TEST: 01                                                                                     TIME: 22:47:44       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-38042          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 56406        
PATHOLOGIST: M. STEDHAM                                                                                        CAS: 25013154        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Midwest Research Inst                                    VINYL TOLUENE                                    DATE: 09/08/94      
EXPERIMENT: 05070 TEST: 01                                                                                     TIME: 22:47:44      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-38042          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 56406       
PATHOLOGIST: M. STEDHAM                                                                                        CAS: 25013154       
 
 
 
 
 
                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Midwest Research Inst                                    VINYL TOLUENE                                    DATE: 09/08/94       
EXPERIMENT: 05070 TEST: 01                                                                                     TIME: 22:47:44       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-38042          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 56406        
PATHOLOGIST: M. STEDHAM                                                                                        CAS: 25013154        
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                         IN THE ANALYSIS OF THE STUDY OF VINYL TOLUENE
 
              ====================================================================================================
 
                                                           MALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Adrenal Medulla               Pheochromocytoma Malignant
                             Thyroid Gland: Follicular Cell
                                                           Carcinoma
                                                           Carcinoma or Adenoma
                             All Organs                    Malignant Tumors
 
              ====================================================================================================
 
                                                           FEMALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Clitoral/Preputial Gland      Carcinoma
                                                           Carcinoma or Adenoma
                             Mammary Gland                 Fibroadenoma
                             All Organs                    Benign Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE   1
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/49 (4%)       0/20 (0%)       0/50 (0%)      |     1/50 (2%)       0/14 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |     10.5%            0.0%            0.0%          |      2.9%            0.0%            0.0%          |
|TERMINAL (d)           |     2/19 (11%)      0/6 (0%)        0/19 (0%)      |     0/31 (0%)       0/4 (0%)        0/26 (0%)      |
|FIRST INCIDENCE (DAYS) |      728 (T)         ---             ---           |      708             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.171N        P=0.513N        P=0.237N       |     P=0.412N        P=0.525N        P=0.525N       |
|INCIDENTAL TUMOR       |     P=0.171N        P=0.513N        P=0.237N       |     P=0.333N        P=0.892N        P=0.455N       |
|LOGISTIC REGRESSION    |     P=0.171N        P=0.513N        P=0.237N       |     P=0.389N        P=0.860N        P=0.515N       |
|COCHRAN-ARMITAGE       |     P=0.169N                                       |     P=0.378N                                       |
|FISHER EXACT           |                     P=0.501N        P=0.242N       |                     P=0.781N        P=0.500N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    14/49 (29%)      6/21 (29%)     14/46 (30%)     |     5/48 (10%)      0/14 (0%)       3/45 (7%)      |
|ADJUSTED (b)           |     51.1%           35.4%           58.2%          |     14.6%            0.0%            9.7%          |
|TERMINAL (d)           |     7/19 (37%)      2/7 (29%)       9/18 (50%)     |     3/31 (10%)      0/4 (0%)        1/23 (4%)      |
|FIRST INCIDENCE (DAYS) |      623             393             541           |      683             ---             456           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.515         P=0.246N        P=0.563N       |     P=0.483N        P=0.177N        P=0.472N       |
|INCIDENTAL TUMOR       |     P=0.525         P=0.516         P=0.553        |     P=0.324N        P=0.446N        P=0.329N       |
|LOGISTIC REGRESSION    |     P=0.558         P=0.528         P=0.590N       |     P=0.399N        P=0.404N        P=0.404N       |
|COCHRAN-ARMITAGE       |     P=0.476                                        |     P=0.383N                                       |
|FISHER EXACT           |                     P=0.619N        P=0.510        |                     P=0.265N        P=0.394N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE   2
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Complex                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/49 (6%)       0/21 (0%)       1/46 (2%)      |     0/48 (0%)       0/14 (0%)       0/45 (0%)      |
|ADJUSTED (b)           |     12.0%            0.0%            5.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     1/19 (5%)       0/7 (0%)        0/18 (0%)      |     0/31 (0%)       0/4 (0%)        0/23 (0%)      |
|FIRST INCIDENCE (DAYS) |      621             ---             724           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.279N        P=0.193N        P=0.297N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.237N        P=0.391N        P=0.279N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.266N        P=0.349N        P=0.305N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.291N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.337N        P=0.333N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/49 (2%)       3/21 (14%)      2/46 (4%)      |     2/48 (4%)       0/14 (0%)       1/45 (2%)      |
|ADJUSTED (b)           |      5.3%           30.9%            9.5%          |      5.0%            0.0%            3.1%          |
|TERMINAL (d)           |     1/19 (5%)       2/7 (29%)       1/18 (6%)      |     0/31 (0%)       0/4 (0%)        0/23 (0%)      |
|FIRST INCIDENCE (DAYS) |      728 (T)         637             701           |      545             ---             690           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.550         P=0.090         P=0.503        |     P=0.529N        P=0.256N        P=0.535N       |
|INCIDENTAL TUMOR       |     P=0.555         P=0.049 *       P=0.526        |     P=0.323N        P=0.371N        P=0.346N       |
|LOGISTIC REGRESSION    |     P=0.576         P=0.034 *       P=0.507        |     P=0.466N        P=0.488N        P=0.512N       |
|COCHRAN-ARMITAGE       |     P=0.527                                        |     P=0.471N                                       |
|FISHER EXACT           |                     P=0.078         P=0.476        |                     P=0.597N        P=0.524N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE   3
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    17/49 (35%)      8/21 (38%)     15/46 (33%)     |     7/48 (15%)      0/14 (0%)       4/45 (9%)      |
|ADJUSTED (b)           |     60.4%           50.0%           60.0%          |     18.9%            0.0%           12.5%          |
|TERMINAL (d)           |     9/19 (47%)      3/7 (43%)       9/18 (50%)     |     3/31 (10%)      0/4 (0%)        1/23 (4%)      |
|FIRST INCIDENCE (DAYS) |      621             393             541           |      545             ---             456           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.410N        P=0.292N        P=0.393N       |     P=0.408N        P=0.058N        P=0.375N       |
|INCIDENTAL TUMOR       |     P=0.403N        P=0.369         P=0.452N       |     P=0.187N        P=0.183N        P=0.170N       |
|LOGISTIC REGRESSION    |     P=0.355N        P=0.362         P=0.404N       |     P=0.308N        P=0.186N        P=0.299N       |
|COCHRAN-ARMITAGE       |     P=0.453N                                       |     P=0.300N                                       |
|FISHER EXACT           |                     P=0.496         P=0.501N       |                     P=0.150N        P=0.300N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/46 (2%)       0/18 (0%)       2/48 (4%)      |     1/48 (2%)       2/11 (18%)      2/46 (4%)      |
|ADJUSTED (b)           |      2.4%            0.0%           10.5%          |      2.8%           27.0%            6.7%          |
|TERMINAL (d)           |     0/19 (0%)       0/5 (0%)        2/19 (11%)     |     0/31 (0%)       1/4 (25%)       1/25 (4%)      |
|FIRST INCIDENCE (DAYS) |      532             ---             728 (T)       |      688             661             680           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.378         P=0.486N        P=0.513        |     P=0.432         P=0.309         P=0.455        |
|INCIDENTAL TUMOR       |     P=0.350         P=0.450N        P=0.482        |     P=0.588         P=0.069         P=0.558        |
|LOGISTIC REGRESSION    |     P=0.401         P=0.553N        P=0.516        |     P=0.505         P=0.053         P=0.477        |
|COCHRAN-ARMITAGE       |     P=0.390                                        |     P=0.512                                        |
|FISHER EXACT           |                     P=0.719N        P=0.516        |                     P=0.086         P=0.484        |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE   4
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/46 (2%)       2/18 (11%)      1/48 (2%)      |     0/48 (0%)       2/11 (18%)      0/46 (0%)      |
|ADJUSTED (b)           |      5.3%           40.0%            3.4%          |      0.0%           50.0%            0.0%          |
|TERMINAL (d)           |     1/19 (5%)       2/5 (40%)       0/19 (0%)      |     0/31 (0%)       2/4 (50%)       0/25 (0%)      |
|FIRST INCIDENCE (DAYS) |      728 (T)         728 (T)         669           |      ---             728 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.542N        P=0.096         P=0.748N       |     P=0.572N        P=0.002 **        (e)          |
|INCIDENTAL TUMOR       |     P=0.476N        P=0.096         P=0.705N       |     P=0.572N        P=0.002 **        (e)          |
|LOGISTIC REGRESSION    |     P=0.491N        P=0.096         P=0.744N       |     P=0.572N        P=0.002 **        (e)          |
|COCHRAN-ARMITAGE       |     P=0.531N                                       |     P=0.532N                                       |
|FISHER EXACT           |                     P=0.189         P=0.742N       |                     P=0.032 *         (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/46 (4%)       2/18 (11%)      3/48 (6%)      |     1/48 (2%)       4/11 (36%)      2/46 (4%)      |
|ADJUSTED (b)           |      7.6%           40.0%           13.6%          |      2.8%           75.7%            6.7%          |
|TERMINAL (d)           |     1/19 (5%)       2/5 (40%)       2/19 (11%)     |     0/31 (0%)       3/4 (75%)       1/25 (4%)      |
|FIRST INCIDENCE (DAYS) |      532             728 (T)         669           |      688             661             680           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.499         P=0.335         P=0.520        |     P=0.515         P=0.007 **      P=0.455        |
|INCIDENTAL TUMOR       |     P=0.531         P=0.354         P=0.532        |     P=0.574N        P<0.001 **      P=0.558        |
|LOGISTIC REGRESSION    |     P=0.555         P=0.208         P=0.530        |     P=0.586         P<0.001 **      P=0.477        |
|COCHRAN-ARMITAGE       |     P=0.514                                        |     P=0.601                                        |
|FISHER EXACT           |                     P=0.313         P=0.520        |                     P=0.003 **      P=0.484        |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE   5
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     6/46 (13%)      3/16 (19%)      5/49 (10%)     |     1/50 (2%)       0/12 (0%)       1/49 (2%)      |
|ADJUSTED (b)           |     27.9%           52.6%           21.6%          |      3.2%            0.0%            2.9%          |
|TERMINAL (d)           |     4/19 (21%)      2/4 (50%)       2/19 (11%)     |     1/31 (3%)       0/3 (0%)        0/26 (0%)      |
|FIRST INCIDENCE (DAYS) |      697             700             700           |      728 (T)         ---             680           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.413N        P=0.478         P=0.470N       |     P=0.634         P=0.927N        P=0.735        |
|INCIDENTAL TUMOR       |     P=0.264N        P=0.170         P=0.371N       |     P=0.681N        P=0.927N        P=0.756N       |
|LOGISTIC REGRESSION    |     P=0.333N        P=0.174         P=0.445N       |     P=0.658         P=0.927N        P=0.748        |
|COCHRAN-ARMITAGE       |     P=0.375N                                       |     P=0.668                                        |
|FISHER EXACT           |                     P=0.423         P=0.455N       |                     P=0.806N        P=0.747        |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/46 (0%)       0/16 (0%)       1/49 (2%)      |     1/50 (2%)       1/12 (8%)       2/49 (4%)      |
|ADJUSTED (b)           |      0.0%            0.0%            5.3%          |      3.2%           33.3%            6.9%          |
|TERMINAL (d)           |     0/19 (0%)       0/4 (0%)        1/19 (5%)      |     1/31 (3%)       1/3 (33%)       1/26 (4%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             728 (T)       |      728 (T)         728 (T)         697           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.351           (e)           P=0.500        |     P=0.403         P=0.206         P=0.445        |
|INCIDENTAL TUMOR       |     P=0.351           (e)           P=0.500        |     P=0.461         P=0.206         P=0.485        |
|LOGISTIC REGRESSION    |     P=0.351           (e)           P=0.500        |     P=0.441         P=0.206         P=0.464        |
|COCHRAN-ARMITAGE       |     P=0.351                                        |     P=0.462                                        |
|FISHER EXACT           |                       (e)           P=0.516        |                     P=0.352         P=0.492        |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE   6
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     6/46 (13%)      3/16 (19%)      5/49 (10%)     |     2/50 (4%)       1/12 (8%)       3/49 (6%)      |
|ADJUSTED (b)           |     27.9%           52.6%           21.6%          |      6.5%           33.3%            9.6%          |
|TERMINAL (d)           |     4/19 (21%)      2/4 (50%)       2/19 (11%)     |     2/31 (6%)       1/3 (33%)       1/26 (4%)      |
|FIRST INCIDENCE (DAYS) |      697             700             700           |      728 (T)         728 (T)         680           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.413N        P=0.478         P=0.470N       |     P=0.379         P=0.311         P=0.437        |
|INCIDENTAL TUMOR       |     P=0.264N        P=0.170         P=0.371N       |     P=0.470         P=0.311         P=0.492        |
|LOGISTIC REGRESSION    |     P=0.333N        P=0.174         P=0.445N       |     P=0.432         P=0.311         P=0.460        |
|COCHRAN-ARMITAGE       |     P=0.375N                                       |     P=0.452                                        |
|FISHER EXACT           |                     P=0.423         P=0.455N       |                     P=0.482         P=0.490        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Lipoma                                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/49 (0%)       0/35 (0%)       2/50 (4%)      |     0/50 (0%)       0/14 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            7.7%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/19 (0%)       0/9 (0%)        1/19 (5%)      |     0/31 (0%)       0/2 (0%)        0/26 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             611           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.115           (e)           P=0.249        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.102           (e)           P=0.218        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.118           (e)           P=0.247        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.112                                        |       (e)                                          |
|FISHER EXACT           |                       (e)           P=0.253        |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE   7
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/49 (4%)       2/42 (5%)       1/50 (2%)      |     0/50 (0%)       0/33 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |     10.5%           11.1%            5.3%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     2/19 (11%)      1/12 (8%)       1/19 (5%)      |     0/31 (0%)       0/13 (0%)       0/26 (0%)      |
|FIRST INCIDENCE (DAYS) |      728 (T)         627             728 (T)       |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.372N        P=0.570         P=0.500N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.396N        P=0.567         P=0.500N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.350N        P=0.588         P=0.500N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.387N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.631         P=0.492N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/49 (0%)       1/50 (2%)       1/50 (2%)      |     3/50 (6%)       1/50 (2%)       2/50 (4%)      |
|ADJUSTED (b)           |      0.0%            5.9%            5.3%          |      9.0%            2.2%            6.1%          |
|TERMINAL (d)           |     0/19 (0%)       1/17 (6%)       1/19 (5%)      |     2/31 (6%)       0/28 (0%)       1/26 (4%)      |
|FIRST INCIDENCE (DAYS) |      ---             728 (T)         728 (T)       |      683             560             576           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.431         P=0.478         P=0.500        |     P=0.548N        P=0.328N        P=0.562N       |
|INCIDENTAL TUMOR       |     P=0.431         P=0.478         P=0.500        |     P=0.524N        P=0.297N        P=0.527N       |
|LOGISTIC REGRESSION    |     P=0.431         P=0.478         P=0.500        |     P=0.494N        P=0.306N        P=0.512N       |
|COCHRAN-ARMITAGE       |     P=0.429                                        |     P=0.500N                                       |
|FISHER EXACT           |                     P=0.505         P=0.505        |                     P=0.309N        P=0.500N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE   8
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/49 (0%)       1/50 (2%)       1/50 (2%)      |     3/50 (6%)       2/50 (4%)       3/50 (6%)      |
|ADJUSTED (b)           |      0.0%            5.9%            5.3%          |      9.0%            5.7%            8.0%          |
|TERMINAL (d)           |     0/19 (0%)       1/17 (6%)       1/19 (5%)      |     2/31 (6%)       1/28 (4%)       1/26 (4%)      |
|FIRST INCIDENCE (DAYS) |      ---             728 (T)         728 (T)       |      683             560             434           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.431         P=0.478         P=0.500        |     P=0.525         P=0.530N        P=0.607        |
|INCIDENTAL TUMOR       |     P=0.431         P=0.478         P=0.500        |     P=0.598         P=0.499N        P=0.624N       |
|LOGISTIC REGRESSION    |     P=0.431         P=0.478         P=0.500        |     P=0.592         P=0.499N        P=0.654N       |
|COCHRAN-ARMITAGE       |     P=0.429                                        |     P=0.577                                        |
|FISHER EXACT           |                     P=0.505         P=0.505        |                     P=0.500N        P=0.661N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/49 (2%)       0/50 (0%)       1/50 (2%)      |    16/50 (32%)      8/50 (16%)      9/50 (18%)     |
|ADJUSTED (b)           |      3.7%            0.0%            4.3%          |     42.3%           25.6%           26.4%          |
|TERMINAL (d)           |     0/19 (0%)       0/17 (0%)       0/19 (0%)      |    10/31 (32%)      6/28 (21%)      4/26 (15%)     |
|FIRST INCIDENCE (DAYS) |      658             ---             704           |      592             583             499           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.676         P=0.479N        P=0.731N       |     P=0.197N        P=0.090N        P=0.181N       |
|INCIDENTAL TUMOR       |     P=0.690N        P=0.448N        P=0.655N       |     P=0.126N        P=0.055N        P=0.093N       |
|LOGISTIC REGRESSION    |     P=0.663         P=0.496N        P=0.748N       |     P=0.121N        P=0.050N*       P=0.096N       |
|COCHRAN-ARMITAGE       |     P=0.652                                        |     P=0.103N                                       |
|FISHER EXACT           |                     P=0.495N        P=0.747N       |                     P=0.050N        P=0.083N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE   9
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/49 (2%)       0/50 (0%)       1/50 (2%)      |    16/50 (32%)      9/50 (18%)     10/50 (20%)     |
|ADJUSTED (b)           |      3.7%            0.0%            4.3%          |     42.3%           29.0%           27.9%          |
|TERMINAL (d)           |     0/19 (0%)       0/17 (0%)       0/19 (0%)      |    10/31 (32%)      7/28 (25%)      4/26 (15%)     |
|FIRST INCIDENCE (DAYS) |      658             ---             704           |      592             583             434           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.676         P=0.479N        P=0.731N       |     P=0.268N        P=0.137N        P=0.248N       |
|INCIDENTAL TUMOR       |     P=0.690N        P=0.448N        P=0.655N       |     P=0.167N        P=0.091N        P=0.122N       |
|LOGISTIC REGRESSION    |     P=0.663         P=0.496N        P=0.748N       |     P=0.166N        P=0.082N        P=0.134N       |
|COCHRAN-ARMITAGE       |     P=0.652                                        |     P=0.151N                                       |
|FISHER EXACT           |                     P=0.495N        P=0.747N       |                     P=0.083N        P=0.127N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/49 (2%)       1/50 (2%)       2/50 (4%)      |    18/50 (36%)     10/50 (20%)     12/50 (24%)     |
|ADJUSTED (b)           |      3.7%            5.9%            9.4%          |     47.8%           30.6%           32.8%          |
|TERMINAL (d)           |     0/19 (0%)       1/17 (6%)       1/19 (5%)      |    12/31 (39%)      7/28 (25%)      5/26 (19%)     |
|FIRST INCIDENCE (DAYS) |      658             728 (T)         704           |      592             560             434           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.423         P=0.760         P=0.530        |     P=0.309N        P=0.107N        P=0.277N       |
|INCIDENTAL TUMOR       |     P=0.471         P=0.745N        P=0.608        |     P=0.200N        P=0.067N        P=0.144N       |
|LOGISTIC REGRESSION    |     P=0.426         P=0.762N        P=0.530        |     P=0.187N        P=0.058N        P=0.147N       |
|COCHRAN-ARMITAGE       |     P=0.399                                        |     P=0.174N                                       |
|FISHER EXACT           |                     P=0.747N        P=0.508        |                     P=0.059N        P=0.138N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE  10
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    31/49 (63%)     21/35 (60%)     30/50 (60%)     |    28/50 (56%)     26/43 (60%)     29/50 (58%)     |
|ADJUSTED (b)           |     92.9%           78.9%           80.0%          |     71.1%           73.7%           71.2%          |
|TERMINAL (d)           |    17/19 (89%)      8/12 (67%)     12/19 (63%)     |    20/31 (65%)     14/22 (64%)     15/26 (58%)     |
|FIRST INCIDENCE (DAYS) |      506             499             512           |      545             495             414           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.431N        P=0.270N        P=0.395N       |     P=0.247         P=0.302         P=0.252        |
|INCIDENTAL TUMOR       |     P=0.396N        P=0.562         P=0.427N       |     P=0.435         P=0.385         P=0.438        |
|LOGISTIC REGRESSION    |     P=0.354N        P=0.481N        P=0.375N       |     P=0.431         P=0.371         P=0.440        |
|COCHRAN-ARMITAGE       |     P=0.435N                                       |     P=0.501                                        |
|FISHER EXACT           |                     P=0.469N        P=0.449N       |                     P=0.412         P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/49 (6%)       1/35 (3%)       1/50 (2%)      |     4/50 (8%)       2/43 (5%)       1/50 (2%)      |
|ADJUSTED (b)           |     11.9%            4.5%            5.3%          |     12.1%            9.1%            2.3%          |
|TERMINAL (d)           |     1/19 (5%)       0/12 (0%)       1/19 (5%)      |     3/31 (10%)      2/22 (9%)       0/26 (0%)      |
|FIRST INCIDENCE (DAYS) |      599             695             728 (T)       |      683             728 (T)         576           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.252N        P=0.369N        P=0.294N       |     P=0.188N        P=0.477N        P=0.226N       |
|INCIDENTAL TUMOR       |     P=0.221N        P=0.416N        P=0.283N       |     P=0.174N        P=0.455N        P=0.201N       |
|LOGISTIC REGRESSION    |     P=0.234N        P=0.434N        P=0.277N       |     P=0.160N        P=0.456N        P=0.186N       |
|COCHRAN-ARMITAGE       |     P=0.254N                                       |     P=0.147N                                       |
|FISHER EXACT           |                     P=0.444N        P=0.301N       |                     P=0.413N        P=0.181N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE  11
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    33/49 (67%)     22/35 (63%)     30/50 (60%)     |    32/50 (64%)     28/43 (65%)     30/50 (60%)     |
|ADJUSTED (b)           |     93.4%           79.8%           80.0%          |     79.5%           80.3%           71.9%          |
|TERMINAL (d)           |    17/19 (89%)      8/12 (67%)     12/19 (63%)     |    23/31 (74%)     16/22 (73%)     15/26 (58%)     |
|FIRST INCIDENCE (DAYS) |      506             499             512           |      545             495             414           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.310N        P=0.231N        P=0.280N       |     P=0.401         P=0.374         P=0.413        |
|INCIDENTAL TUMOR       |     P=0.227N        P=0.569N        P=0.262N       |     P=0.451N        P=0.490         P=0.492N       |
|LOGISTIC REGRESSION    |     P=0.203N        P=0.435N        P=0.226N       |     P=0.444N        P=0.489         P=0.481N       |
|COCHRAN-ARMITAGE       |     P=0.276N                                       |     P=0.369N                                       |
|FISHER EXACT           |                     P=0.422N        P=0.291N       |                     P=0.542         P=0.418N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/49 (4%)       4/50 (8%)       5/50 (10%)     |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      8.3%           17.7%           20.6%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     1/19 (5%)       2/17 (12%)      3/19 (16%)     |     0/31 (0%)       0/28 (0%)       0/26 (0%)      |
|FIRST INCIDENCE (DAYS) |      638             479             589           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.235         P=0.307         P=0.241        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.210         P=0.334         P=0.220        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.228         P=0.345         P=0.246        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.208                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.349         P=0.226        |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE  12
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/49 (2%)       0/50 (0%)       1/50 (2%)      |     2/50 (4%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      2.2%            0.0%            5.3%          |      5.9%            0.0%            0.0%          |
|TERMINAL (d)           |     0/19 (0%)       0/17 (0%)       1/19 (5%)      |     1/31 (3%)       0/28 (0%)       0/26 (0%)      |
|FIRST INCIDENCE (DAYS) |      506             ---             728 (T)       |      688             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.658         P=0.504N        P=0.751N       |     P=0.192N        P=0.251N        P=0.273N       |
|INCIDENTAL TUMOR       |     P=0.608         P=0.500N        P=0.716        |     P=0.169N        P=0.215N        P=0.234N       |
|LOGISTIC REGRESSION    |     P=0.631         P=0.519N        P=0.744        |     P=0.180N        P=0.239N        P=0.253N       |
|COCHRAN-ARMITAGE       |     P=0.652                                        |     P=0.171N                                       |
|FISHER EXACT           |                     P=0.495N        P=0.747N       |                     P=0.247N        P=0.247N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma,                                                                |
|     Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/49 (6%)       4/50 (8%)       7/50 (14%)     |     2/50 (4%)       0/50 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |     10.3%           17.7%           27.6%          |      5.9%            0.0%            3.8%          |
|TERMINAL (d)           |     1/19 (5%)       2/17 (12%)      4/19 (21%)     |     1/31 (3%)       0/28 (0%)       1/26 (4%)      |
|FIRST INCIDENCE (DAYS) |      506             479             589           |      688             ---             728 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.146         P=0.465         P=0.187        |     P=0.544N        P=0.251N        P=0.554N       |
|INCIDENTAL TUMOR       |     P=0.107         P=0.494         P=0.138        |     P=0.517N        P=0.215N        P=0.515N       |
|LOGISTIC REGRESSION    |     P=0.128         P=0.511         P=0.174        |     P=0.528N        P=0.239N        P=0.533N       |
|COCHRAN-ARMITAGE       |     P=0.120                                        |     P=0.500N                                       |
|FISHER EXACT           |                     P=0.511         P=0.167        |                     P=0.247N        P=0.500N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE  13
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/49 (4%)       1/50 (2%)       1/50 (2%)      |     3/50 (6%)       2/50 (4%)       1/50 (2%)      |
|ADJUSTED (b)           |      7.8%            4.3%            3.1%          |      7.2%            5.9%            3.1%          |
|TERMINAL (d)           |     1/19 (5%)       0/17 (0%)       0/19 (0%)      |     0/31 (0%)       1/28 (4%)       0/26 (0%)      |
|FIRST INCIDENCE (DAYS) |      599             694             660           |      434             637             690           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.416N        P=0.516N        P=0.473N       |     P=0.286N        P=0.518N        P=0.338N       |
|INCIDENTAL TUMOR       |     P=0.389N        P=0.483N        P=0.470N       |     P=0.199N        P=0.455N        P=0.199N       |
|LOGISTIC REGRESSION    |     P=0.429N        P=0.495N        P=0.488N       |     P=0.243N        P=0.548N        P=0.300N       |
|COCHRAN-ARMITAGE       |     P=0.440N                                       |     P=0.252N                                       |
|FISHER EXACT           |                     P=0.492N        P=0.492N       |                     P=0.500N        P=0.309N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/49 (6%)       1/50 (2%)       1/50 (2%)      |     1/50 (2%)       1/50 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |     13.6%            5.9%            2.2%          |      3.2%            2.9%            3.8%          |
|TERMINAL (d)           |     2/19 (11%)      1/17 (6%)       0/19 (0%)      |     1/31 (3%)       0/28 (0%)       1/26 (4%)      |
|FIRST INCIDENCE (DAYS) |      647             728 (T)         541           |      728 (T)         701             728 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.251N        P=0.332N        P=0.279N       |     P=0.637         P=0.746         P=0.723        |
|INCIDENTAL TUMOR       |     P=0.265N        P=0.311N        P=0.300N       |     P=0.666         P=0.738N        P=0.723        |
|LOGISTIC REGRESSION    |     P=0.253N        P=0.308N        P=0.293N       |     P=0.653         P=0.758         P=0.723        |
|COCHRAN-ARMITAGE       |     P=0.266N                                       |     P=0.680                                        |
|FISHER EXACT           |                     P=0.301N        P=0.301N       |                     P=0.753N        P=0.753N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE  14
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibroma or Fibroma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/49 (4%)       1/50 (2%)       2/50 (4%)      |     3/50 (6%)       2/50 (4%)       1/50 (2%)      |
|ADJUSTED (b)           |      7.8%            4.3%            8.2%          |      7.2%            5.9%            3.1%          |
|TERMINAL (d)           |     1/19 (5%)       0/17 (0%)       1/19 (5%)      |     0/31 (0%)       1/28 (4%)       0/26 (0%)      |
|FIRST INCIDENCE (DAYS) |      599             694             660           |      434             637             690           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.623         P=0.516N        P=0.672N       |     P=0.286N        P=0.518N        P=0.338N       |
|INCIDENTAL TUMOR       |     P=0.635N        P=0.483N        P=0.670N       |     P=0.199N        P=0.455N        P=0.199N       |
|LOGISTIC REGRESSION    |     P=0.622         P=0.495N        P=0.673N       |     P=0.243N        P=0.548N        P=0.300N       |
|COCHRAN-ARMITAGE       |     P=0.602                                        |     P=0.252N                                       |
|FISHER EXACT           |                     P=0.492N        P=0.684N       |                     P=0.500N        P=0.309N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, Sarcoma,                                                                                   |
|     Neurofibroma, or Fibroma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     6/49 (12%)      3/50 (6%)       3/50 (6%)      |     4/50 (8%)       3/50 (6%)       2/50 (4%)      |
|ADJUSTED (b)           |     23.5%           12.0%           10.2%          |     10.2%            8.7%            6.9%          |
|TERMINAL (d)           |     3/19 (16%)      1/17 (6%)       1/19 (5%)      |     1/31 (3%)       1/28 (4%)       1/26 (4%)      |
|FIRST INCIDENCE (DAYS) |      599             519             541           |      434             637             690           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.203N        P=0.270N        P=0.210N       |     P=0.346N        P=0.526N        P=0.393N       |
|INCIDENTAL TUMOR       |     P=0.227N        P=0.241N        P=0.238N       |     P=0.251N        P=0.445N        P=0.271N       |
|LOGISTIC REGRESSION    |     P=0.218N        P=0.233N        P=0.221N       |     P=0.281N        P=0.525N        P=0.326N       |
|COCHRAN-ARMITAGE       |     P=0.226N                                       |     P=0.291N                                       |
|FISHER EXACT           |                     P=0.233N        P=0.233N       |                     P=0.500N        P=0.339N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE  15
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, or Sarcoma                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/49 (8%)       2/50 (4%)       1/50 (2%)      |     1/50 (2%)       1/50 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |     16.5%            8.0%            2.2%          |      3.2%            2.9%            3.8%          |
|TERMINAL (d)           |     2/19 (11%)      1/17 (6%)       0/19 (0%)      |     1/31 (3%)       0/28 (0%)       1/26 (4%)      |
|FIRST INCIDENCE (DAYS) |      643             519             541           |      728 (T)         701             728 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.132N        P=0.359N        P=0.155N       |     P=0.637         P=0.746         P=0.723        |
|INCIDENTAL TUMOR       |     P=0.169N        P=0.345N        P=0.190N       |     P=0.666         P=0.738N        P=0.723        |
|LOGISTIC REGRESSION    |     P=0.148N        P=0.329N        P=0.172N       |     P=0.653         P=0.758         P=0.723        |
|COCHRAN-ARMITAGE       |     P=0.146N                                       |     P=0.680                                        |
|FISHER EXACT           |                     P=0.329N        P=0.175N       |                     P=0.753N        P=0.753N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    35/49 (71%)     31/42 (74%)     41/50 (82%)     |                                                    |
|ADJUSTED (b)           |     94.1%           93.2%           97.5%          |                                                    |
|TERMINAL (d)           |    17/19 (89%)     14/16 (88%)     18/19 (95%)     |                                                    |
|FIRST INCIDENCE (DAYS) |      422             484             506           |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.275         P=0.471N        P=0.332        |                                                    |
|INCIDENTAL TUMOR       |     P=0.154         P=0.519         P=0.153        |                                                    |
|LOGISTIC REGRESSION    |     P=0.206         P=0.516         P=0.220        |                                                    |
|COCHRAN-ARMITAGE       |     P=0.131                                        |                                                    |
|FISHER EXACT           |                     P=0.494         P=0.157        |                                                    |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE  16
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/49 (14%)      2/20 (10%)      7/50 (14%)     |     7/50 (14%)      0/10 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |     28.0%           33.3%           26.8%          |     19.6%            0.0%            7.7%          |
|TERMINAL (d)           |     2/19 (11%)      2/6 (33%)       3/19 (16%)     |     4/31 (13%)      0/0             2/26 (8%)      |
|FIRST INCIDENCE (DAYS) |      647             728 (T)         617           |      659             ---             728 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.539         P=0.262N        P=0.566N       |     P=0.109N        P=0.131N        P=0.126N       |
|INCIDENTAL TUMOR       |     P=0.376N        P=0.611         P=0.411N       |     P=0.074N        P=0.638N        P=0.090N       |
|LOGISTIC REGRESSION    |     P=0.506N        P=0.656N        P=0.548N       |     P=0.084N        P=0.506N        P=0.099N       |
|COCHRAN-ARMITAGE       |     P=0.566                                        |     P=0.070N                                       |
|FISHER EXACT           |                     P=0.483N        P=0.597N       |                     P=0.259N        P=0.080N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/49 (2%)       1/20 (5%)       1/50 (2%)      |     0/50 (0%)       0/10 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |      2.9%           16.7%            3.4%          |      0.0%            0.0%            7.7%          |
|TERMINAL (d)           |     0/19 (0%)       1/6 (17%)       0/19 (0%)      |     0/31 (0%)       0/0             2/26 (8%)      |
|FIRST INCIDENCE (DAYS) |      623             728 (T)         669           |      ---             ---             728 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.637N        P=0.642         P=0.739N       |     P=0.140           (e)           P=0.200        |
|INCIDENTAL TUMOR       |     P=0.578N        P=0.469         P=0.734N       |     P=0.140           (e)           P=0.200        |
|LOGISTIC REGRESSION    |     P=0.598N        P=0.500         P=0.763        |     P=0.140           (e)           P=0.200        |
|COCHRAN-ARMITAGE       |     P=0.619N                                       |     P=0.150                                        |
|FISHER EXACT           |                     P=0.499         P=0.747N       |                       (e)           P=0.247        |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE  17
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     8/49 (16%)      3/20 (15%)      8/50 (16%)     |     7/50 (14%)      0/10 (0%)       4/50 (8%)      |
|ADJUSTED (b)           |     30.1%           50.0%           29.3%          |     19.6%            0.0%           15.4%          |
|TERMINAL (d)           |     2/19 (11%)      3/6 (50%)       3/19 (16%)     |     4/31 (13%)      0/0             4/26 (15%)     |
|FIRST INCIDENCE (DAYS) |      623             728 (T)         617           |      659             ---             728 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.551         P=0.341N        P=0.552N       |     P=0.345N        P=0.131N        P=0.358N       |
|INCIDENTAL TUMOR       |     P=0.348N        P=0.415         P=0.401N       |     P=0.269N        P=0.638N        P=0.299N       |
|LOGISTIC REGRESSION    |     P=0.474N        P=0.510         P=0.541N       |     P=0.286N        P=0.506N        P=0.312N       |
|COCHRAN-ARMITAGE       |     P=0.562N                                       |     P=0.254N                                       |
|FISHER EXACT           |                     P=0.602N        P=0.590N       |                     P=0.259N        P=0.262N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/49 (0%)       2/20 (10%)      1/50 (2%)      |     0/50 (0%)       0/10 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |      0.0%           33.3%            5.3%          |      0.0%            0.0%            3.8%          |
|TERMINAL (d)           |     0/19 (0%)       2/6 (33%)       1/19 (5%)      |     0/31 (0%)       0/0             1/26 (4%)      |
|FIRST INCIDENCE (DAYS) |      ---             728 (T)         728 (T)       |      ---             ---             728 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.549         P=0.042 *       P=0.500        |     P=0.336           (e)           P=0.465        |
|INCIDENTAL TUMOR       |     P=0.549         P=0.042 *       P=0.500        |     P=0.336           (e)           P=0.465        |
|LOGISTIC REGRESSION    |     P=0.549         P=0.042 *       P=0.500        |     P=0.336           (e)           P=0.465        |
|COCHRAN-ARMITAGE       |     P=0.548                                        |     P=0.352                                        |
|FISHER EXACT           |                     P=0.081         P=0.505        |                       (e)           P=0.500        |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE  18
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/49 (0%)       2/20 (10%)      1/50 (2%)      |     0/50 (0%)       0/10 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |      0.0%           33.3%            5.3%          |      0.0%            0.0%            7.7%          |
|TERMINAL (d)           |     0/19 (0%)       2/6 (33%)       1/19 (5%)      |     0/31 (0%)       0/0             2/26 (8%)      |
|FIRST INCIDENCE (DAYS) |      ---             728 (T)         728 (T)       |      ---             ---             728 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.549         P=0.042 *       P=0.500        |     P=0.140           (e)           P=0.200        |
|INCIDENTAL TUMOR       |     P=0.549         P=0.042 *       P=0.500        |     P=0.140           (e)           P=0.200        |
|LOGISTIC REGRESSION    |     P=0.549         P=0.042 *       P=0.500        |     P=0.140           (e)           P=0.200        |
|COCHRAN-ARMITAGE       |     P=0.548                                        |     P=0.150                                        |
|FISHER EXACT           |                     P=0.081         P=0.505        |                       (e)           P=0.247        |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Papilloma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/48 (0%)       0/12 (0%)       2/49 (4%)      |     0/49 (0%)       0/9 (0%)        0/46 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%           10.5%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/18 (0%)       0/2 (0%)        2/19 (11%)     |     0/30 (0%)       0/0             0/25 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             728 (T)       |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.167           (e)           P=0.249        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.167           (e)           P=0.249        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.167           (e)           P=0.249        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.148                                        |       (e)                                          |
|FISHER EXACT           |                       (e)           P=0.253        |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE  19
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     7/50 (14%)      6/50 (12%)      5/50 (10%)     |
|ADJUSTED (b)           |                                                    |     19.2%           19.6%           17.1%          |
|TERMINAL (d)           |                                                    |     4/31 (13%)      5/28 (18%)      2/26 (8%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      434             526             709           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.442N        P=0.556N        P=0.478N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.316N        P=0.483N        P=0.326N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.367N        P=0.499N        P=0.403N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.344N                                       |
|FISHER EXACT           |                                                    |                     P=0.500N        P=0.380N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     8/50 (16%)      6/50 (12%)      5/50 (10%)     |
|ADJUSTED (b)           |                                                    |     22.2%           19.6%           17.1%          |
|TERMINAL (d)           |                                                    |     5/31 (16%)      5/28 (18%)      2/26 (8%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      434             526             709           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.350N        P=0.448N        P=0.376N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.236N        P=0.376N        P=0.238N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.279N        P=0.385N        P=0.302N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.256N                                       |
|FISHER EXACT           |                                                    |                     P=0.387N        P=0.277N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE  20
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear,                                                                              |
|     or Undifferentiated                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    25/49 (51%)     26/50 (52%)     20/50 (40%)     |    20/50 (40%)     16/50 (32%)     25/50 (50%)     |
|ADJUSTED (b)           |     67.8%           67.2%           52.9%          |     47.0%           36.5%           66.5%          |
|TERMINAL (d)           |     8/19 (42%)      7/17 (41%)      5/19 (26%)     |     9/31 (29%)      3/28 (11%)     14/26 (54%)     |
|FIRST INCIDENCE (DAYS) |      422             393             512           |      582             421             444           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.145N        P=0.462         P=0.190N       |     P=0.081         P=0.354N        P=0.116        |
|INCIDENTAL TUMOR       |     P=0.144N        P=0.580         P=0.169N       |     P=0.177         P=0.138N        P=0.210        |
|LOGISTIC REGRESSION    |     P=0.159N        P=0.542         P=0.196N       |     P=0.128         P=0.188N        P=0.182        |
|COCHRAN-ARMITAGE       |     P=0.137N                                       |     P=0.124                                        |
|FISHER EXACT           |                     P=0.541         P=0.184N       |                     P=0.266N        P=0.211        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma Benign, Malignant, NOS                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/49 (6%)       1/50 (2%)       1/50 (2%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      7.8%            2.9%            2.7%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/19 (0%)       0/17 (0%)       0/19 (0%)      |     0/31 (0%)       0/28 (0%)       0/26 (0%)      |
|FIRST INCIDENCE (DAYS) |      492             623             638           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.238N        P=0.301N        P=0.262N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.316N        P=0.283N        P=0.352N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.334N        P=0.304N        P=0.402N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.266N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.301N        P=0.301N       |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE  21
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    48/49 (98%)     45/50 (90%)     49/50 (98%)     |    44/50 (88%)     34/50 (68%)     39/50 (78%)     |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |     93.6%           80.3%           84.6%          |
|TERMINAL (d)           |    19/19 (100%)    17/17 (100%)    19/19 (100%)    |    28/31 (90%)     20/28 (71%)     19/26 (73%)     |
|FIRST INCIDENCE (DAYS) |      422             393             506           |      434             495             414           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.429N        P=0.490N        P=0.442N       |     P=0.418         P=0.158N        P=0.521        |
|INCIDENTAL TUMOR       |     P=0.550         P=0.098N        P=0.759        |     P=0.245N        P=0.010N*       P=0.096N       |
|LOGISTIC REGRESSION    |     P=0.633         P=0.080N        P=0.648N       |     P=0.302N        P=0.011N*       P=0.161N       |
|COCHRAN-ARMITAGE       |     P=0.451                                        |     P=0.264N                                       |
|FISHER EXACT           |                     P=0.107N        P=0.747        |                     P=0.014N*       P=0.143N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    38/49 (78%)     37/50 (74%)     29/50 (58%)     |    28/50 (56%)     23/50 (46%)     31/50 (62%)     |
|ADJUSTED (b)           |     86.3%           88.8%           70.2%          |     64.6%           51.8%           78.7%          |
|TERMINAL (d)           |    13/19 (68%)     13/17 (76%)      8/19 (42%)     |    16/31 (52%)      8/28 (29%)     18/26 (69%)     |
|FIRST INCIDENCE (DAYS) |      422             393             506           |      545             421             444           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.058N        P=0.542         P=0.083N       |     P=0.124         P=0.347N        P=0.160        |
|INCIDENTAL TUMOR       |     P=0.021N*       P=0.415N        P=0.026N*      |     P=0.271         P=0.128N        P=0.305        |
|LOGISTIC REGRESSION    |     P=0.020N*       P=0.429N        P=0.017N*      |     P=0.220         P=0.215N        P=0.290        |
|COCHRAN-ARMITAGE       |     P=0.018N*                                      |     P=0.228                                        |
|FISHER EXACT           |                     P=0.430N        P=0.031N*      |                     P=0.212N        P=0.342        |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05070 TEST: 01                                                 PAGE  22
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         100 PPM         300 PPM       |      CONTROL         100 PPM         300 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    48/49 (98%)     50/50 (100%)    50/50 (100%)    |    48/50 (96%)     41/50 (82%)     46/50 (92%)     |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |    100.0%           85.3%           93.9%          |
|TERMINAL (d)           |    19/19 (100%)    17/17 (100%)    19/19 (100%)    |    31/31 (100%)    21/28 (75%)     23/26 (88%)     |
|FIRST INCIDENCE (DAYS) |      422             393             506           |      434             421             414           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.423N        P=0.363         P=0.491N       |     P=0.244         P=0.325N        P=0.302        |
|INCIDENTAL TUMOR       |     P=0.457         P=0.500         P=0.581        |     P=0.392N        P=0.010N*       P=0.242N       |
|LOGISTIC REGRESSION    |     P=0.457         P=0.500         P=0.581        |     P=0.524N        P=0.020N*       P=0.333N       |
|COCHRAN-ARMITAGE       |     P=0.391                                        |     P=0.500N                                       |
|FISHER EXACT           |                     P=0.495         P=0.495        |                     P=0.026N*       P=0.339N       |
|=================================================================================================================================|
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).

--multipart-boundary
Content-type: text/plain
Range: bytes 151581-151581/151581


--multipart-boundary--
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.