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TDMS Study 05070-01 Pathology Tables

NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19




       Facility:  Midwest Research Institute

       Chemical CAS #:  25013154

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|             
                                           | 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    |                                        X                                X|             
      Artery, Inflammation, Chronic, Focal |                      2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X  X                                         X  X        X|             
      Muscularis, Atrophy, Focal           |                      4                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Parasite Metazoan                    | X                                X                                       |             
      Mucosa, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                              2                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     |                   X                             X                    X   |             
      Basophilic Focus, Multiple           |          X                 X     X  X  X     X           X     X        X|             
      Clear Cell Focus                     |                                              X                           |             
      Cytomegaly, Multifocal               |                      3                                                   |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |                      3  2                                                |             
      Fatty Change, Multifocal             |                                                                          |             
      Fibrosis, Multifocal                 |                      2                                                   |             
      Granuloma, Multifocal                | 2  4           3  2     1  1  2                 2        2  2  2         |             
      Hepatodiaphragmatic Nodule           | X                                                                        |             
      Hepatodiaphragmatic Nodule, Multiple |                                     X                                    |             
      Hyperplasia, Multifocal, Nodular     |       2                                                                  |             
      Mixed Cell Focus                     |                                                                      X   |             
      Necrosis, Focal                      |                               2                                          |             
      Necrosis, Multifocal                 |             1        2                    2           2     2            |             
      Bile Duct, Hyperplasia, Focal        |                                                 2                        |             
      Bile Duct, Hyperplasia, Multifocal   |          1           2           1                                       |             
      Centrilobular, Atrophy, Multifocal   |                                                                          |             
      Centrilobular, Degeneration, Diffuse |                                                                          |             
      Centrilobular, Fatty Change, Diffuse |             4                             2                              |             
      Centrilobular, Necrosis, Multifocal  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                     +            |             
      Fat, Necrosis, Focal                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|             
                                           | 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Diffuse             |    3                                                                     |             
      Acinus, Atrophy, Focal               |                                  1                                       |             
      Acinus, Atrophy, Multifocal          |       2     2        2     1                 2  1        1               |             
      Acinus, Hyperplasia, Focal           |          3                                                               |             
      Artery, Inflammation, Chronic, Focal |                                           2                              |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                      2                                                   |             
      Interlobular, Inflammation, Chronic, |                                                                          |             
           Diffuse                         |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       |                                                    4                     |             
      Inflammation, Chronic Active, Focal  |                2                                                         |             
      Duct, Inflammation, Chronic Active,  |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      3                                                   |             
      Ulcer, Single, Subacute              |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      3                                                   |             
      Mucosa, Cyst, Multiple               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess, Single                      |                                                                          |             
      Cardiomyopathy                       | 3     2  2     2  3     1  2     2  1  2     3  2     2  3  2  3     1  2|             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                                          |             
      Atrium Left, Thrombosis              |                                                                          |             
      Valve, Degeneration, Mucoid,         |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                   X                    X                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                        3                                 |             
      Angiectasis, Multifocal              |                               2                                         3|             
      Congestion                           |       4              3                                      2            |             
      Degeneration, Diffuse, Fatty         |             2                                                            |             
      Degeneration, Fatty, Focal           |          2        2        3                    3                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|             
                                           | 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Degeneration, Fatty, Multifocal      |                      3                                                   |             
      Hyperplasia, Focal                   |          2     2        3                    3                 1  2      |             
      Hypertrophy, Focal                   |             1                                                            |             
      Hypertrophy, Multifocal              |                                                                          |             
      Pigmentation, Diffuse, Hemosiderin   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Angiectasis, Multifocal              |                               2                                          |             
      Hyperplasia, Focal                   | 1                    3                          3     2                  |             
      Hyperplasia, Multifocal              |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue, Focal                |                X                                                         |             
      Hyperplasia, Multifocal              |                                                 3                        |             
      Hypertrophy, Focal                   |                                           2                              |             
      Hypoplasia, Diffuse                  |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                   4                       3                              |             
      Pars Distalis, Angiectasis,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Pars Distalis, Cyst                  |                                                                2         |             
      Pars Distalis, Hemorrhage, Chronic,  |                                                                          |             
           Focal                           |                                           3                              |             
      Pars Distalis, Hyperplasia, Focal    |          3                                3                              |             
      Pars Distalis, Hyperplasia           |                                                       3                  |             
      Pars Distalis, Pigmentation, Diffuse,|                                                                          |             
           Hemosiderin                     |                                                                          |             
      Pars Intermedia, Pigmentation,       |                                                                          |             
          Diffuse, Hemosiderin             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      C-Cell, Hyperplasia, Focal           | 1                                                                        |             
      C-Cell, Hyperplasia, Multifocal      |          2        2     1              1  1  2              2  2        3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Hyperplasia                          | 3                                                                        |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|             
                                           | 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Angiectasis, Multifocal              |                                              2                           |             
      Congestion, Diffuse                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           4                              |             
      Dilatation                           |                      4                                                   |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Endometrium, Hyperplasia, Focal      |                         1                                                |             
      Epithelium, Hyperplasia, Diffuse     |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                  +                                       |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         2|             
      Metaplasia, Diffuse, Osseous         |    3                                                                     |             
      Myeloid Cell, Hyperplasia            |                                                                3     2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |    2                                                                     |             
      Mediastinal, Hemorrhage              |             2                    3                                       |             
      Pancreatic, Hemorrhage               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                           2        3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +|             
      Hemorrhage                           |                               1                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Hyperplasia, Re Cell                 |                                                                         2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma, Multifocal                |                   2                                                      |             
      Hematopoietic Cell Proliferation     |                         2                                            2  1|             
      Hyperplasia, Multifocal, Reticulum   |                                                                          |             
          Cell                             |                                                                          |             
      Pigmentation, Hemosiderin            |                         2  3  2  2  3  2                                 |             
      Capsule, Ectopic Tissue              |                                                                          |             
      Capsule, Infiltration Cellular,      |                                                                          |             
          Multifocal, Lymphocyte           |                3                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  M  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Parathyroid Gland            |                      X                                                   |             
      Hyperplasia, Diffuse, Tubular        |                3        2        2           2              2            |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Artery, Mediastinum, Inflammation,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|             
                                           | 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Chronic Active, Multifocal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Ectasia, Focal                       |                                                                          |             
      Ectasia, Multifocal                  |       2        2     2        3                       2              2  2|             
      Hyperplasia, Diffuse                 | 2  2        1     2                    1  2  1              2            |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                                                2         |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                         2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    X           X        X     X        X              X     X            |             
      Hemorrhage, Focal                    |                      1                                                   |             
      Hemorrhage, Multifocal               |                                                                          |             
      Hydrocephalus                        |                         2     2                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                               2                                          |             
      Inflammation, Chronic, Diffuse       |                            4                                             |             
      Inflammation, Chronic, Focal         |          4                                         2     3              2|             
      Inflammation, Chronic Active, Focal  |                                        3                    1     2  3   |             
      Submucosa, Dilatation, Multifocal    |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                     3                                    |             
      Hemorrhage, Acute, Multifocal        |                                  2                                       |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |                                  2                                       |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                3                                                         |             
      Peribronchial, Hyperplasia, Lymphoid,|                                                                          |             
           Multifocal                      |                                                    2                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                                                                          |             
      Lumen, Foreign Body                  | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|             
                                           | 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Inflammation, Chronic        | 4                                                                        |             
      Mucosa, Inflammation, Chronic Active |                                                                          |             
      Mucosa, Metaplasia, Focal            | 3                                                                        |             
      Mucosa, Thrombosis, Multifocal       |             3                                                            |             
      Nasolacrimal Duct, Exudate           |    2                 2                                                   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |             2     2           2              1                           |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |    3                 2                                                   |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Eosinophil                      |                                                 2                        |             
      Respiratory Epithelium, Hyperplasia  |                                                       2              1   |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Multifocal                      | 4                                                                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                               2                                          |             
      Inflammation, Chronic, Focal         |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 4  3  3  2  2  3  2  3  4  3  4  3  3  2  2  1  4     3  3  3     1  3  1|             
      Pigmentation, Diffuse                |       1              3                                                  1|             
      Pigmentation, Multifocal             |          2     2  1     2     2        2     1                           |             
      Cortex, Cyst                         |                                                 X                        |             
      Cortex, Hyperplasia, Atypical, Focal |                                                                          |             
      Cortex, Inflammation, Focal,         |                                                                          |             
          Suppurative                      |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis, Multifocal            |                                                                          |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization, Focal            |                                                                          |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization, Multifocal       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5|            |
                                           | 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |          2                                                               |      1  2.0|
      Parasite Metazoan                    |                                                                          |      2     |
      Artery, Inflammation, Chronic, Focal |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |       X     X                                                            |      7     |
      Muscularis, Atrophy, Focal           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                                                                          |      2     |
      Mucosa, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic, Diffuse       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                               1     3           3                        |      3  2.3|
      Basophilic Focus                     |                         X     X              X  X                    X   |      8     |
      Basophilic Focus, Multiple           | X        X  X  X  X                 X     X        X  X           X      |     19     |
      Clear Cell Focus                     |                                                                          |      1     |
      Cytomegaly, Multifocal               |                                                                          |      1  3.0|
      Cytoplasmic Alteration, Focal        |                                                 3                        |      1  3.0|
      Eosinophilic Focus                   |                                                                      X   |      1     |
      Fatty Change, Diffuse                |                                  2                                       |      3  2.3|
      Fatty Change, Multifocal             |                   1           1        1  1        1        3           4|      7  1.7|
      Fibrosis, Multifocal                 |                                                                          |      1  2.0|
      Granuloma, Multifocal                |          1              1  1  1     2        2     2              1      |     19  1.8|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |      1     |
      Hyperplasia, Multifocal, Nodular     |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Necrosis, Multifocal                 |                   2                                            2        1|      8  1.8|
      Bile Duct, Hyperplasia, Focal        |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia, Multifocal   |                      2                                   1              3|      6  1.7|
      Centrilobular, Atrophy, Multifocal   |                      3                                                   |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5|            |
                                           | 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Centrilobular, Degeneration, Diffuse |                                  2                                       |      1  2.0|
      Centrilobular, Fatty Change, Diffuse |                      4                                         4         |      4  3.2|
      Centrilobular, Necrosis, Multifocal  |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                    +           +         |   4        |
      Fat, Necrosis, Focal                 |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy, Diffuse             |                            4                                             |      2  3.5|
      Acinus, Atrophy, Focal               |                                                                          |      1  1.0|
      Acinus, Atrophy, Multifocal          | 2  2                                      1     1     1                 2|     13  1.5|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic, Focal |                                     3                                    |      2  2.5|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Interlobular, Inflammation, Chronic, |                                                                          |            |
           Diffuse                         |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Diffuse       |                                                                          |      1  4.0|
      Inflammation, Chronic Active, Focal  |                                                                          |      1  2.0|
      Duct, Inflammation, Chronic Active,  |                                                                          |            |
           Focal                           |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                  4                             3         |      3  3.3|
      Ulcer, Single, Subacute              |                                                                         3|      1  3.0|
      Epithelium, Hyperplasia              |                                  4                                      2|      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mucosa, Cyst, Multiple               |                         2              2                                 |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess, Single                      |                                                                         2|      1  2.0|
      Cardiomyopathy                       | 2  2  1  3  3        3  3  2     2     2  1  2  2  2  2  2  1     2      |     36  2.1|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                     4                                    |      1  4.0|
      Atrium Left, Thrombosis              |                                                                4        2|      2  3.0|
      Valve, Degeneration, Mucoid,         |                                                                          |            |
          Multifocal                       |                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5|            |
                                           | 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                         X  X                    X                        |      5     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                          2               |      2  2.5|
      Angiectasis, Multifocal              |          1        2                                                      |      4  2.0|
      Congestion                           |                                        3                                 |      4  3.0|
      Degeneration, Diffuse, Fatty         |                                                                          |      1  2.0|
      Degeneration, Fatty, Focal           |                2        2        2                                      3|      8  2.4|
      Degeneration, Fatty, Multifocal      | 2                                                                        |      2  2.5|
      Hyperplasia, Focal                   |                2     1  3                                                |      9  2.1|
      Hypertrophy, Focal                   |             2  4                    1                                    |      4  2.0|
      Hypertrophy, Multifocal              |                                                       2              2   |      2  2.0|
      Pigmentation, Diffuse, Hemosiderin   |                                  3                                      2|      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis, Multifocal              |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                2         |      5  2.2|
      Hyperplasia, Multifocal              |                                           2                             2|      2  2.0|
      Vacuolization Cytoplasmic, Diffuse   |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectopic Tissue, Focal                |                                                                          |      1     |
      Hyperplasia, Multifocal              |    2                                                                     |      2  2.5|
      Hypertrophy, Focal                   |                                                                   1      |      2  1.5|
      Hypoplasia, Diffuse                  | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis, Focal    |             2           3                                                |      4  3.0|
      Pars Distalis, Angiectasis,          |                                                                          |            |
          Multifocal                       |                   1                                                     4|      2  2.5|
      Pars Distalis, Cyst                  |       3                                               2     2     3      |      5  2.4|
      Pars Distalis, Hemorrhage, Chronic,  |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |             3                                                            |      3  3.0|
      Pars Distalis, Hyperplasia           |                                                                          |      1  3.0|
      Pars Distalis, Pigmentation, Diffuse,|                                                                          |            |
           Hemosiderin                     |                                  2                                       |      1  2.0|
      Pars Intermedia, Pigmentation,       |                                                                          |            |
          Diffuse, Hemosiderin             |                                  2                                       |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5|            |
                                           | 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                 X     1                  |      2  1.0|
      C-Cell, Hyperplasia, Focal           |          3                                                               |      2  2.0|
      C-Cell, Hyperplasia, Multifocal      | 2                 2  3  2     2     2     2     2  2     2        2  3   |     21  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          | 3                                   4                                    |      3  3.3|
      Inflammation, Acute                  |                                                       2           2      |      2  2.0|
      Inflammation, Chronic Active         |                                     4                                    |      1  4.0|
      Inflammation, Granulomatous          |          4                                                               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Multifocal              |                                                                          |      1  2.0|
      Congestion, Diffuse                  |                         2                                                |      1  2.0|
      Hyperplasia                          |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  4.0|
      Dilatation                           |                                                                          |      1  4.0|
      Inflammation, Acute, Multifocal      |                            4                                             |      1  4.0|
      Inflammation, Chronic Active         |       4                                                                  |      1  4.0|
      Endometrium, Hyperplasia, Focal      |                                                                          |      1  1.0|
      Epithelium, Hyperplasia, Diffuse     |                                                                      2   |      1  2.0|
      Epithelium, Hyperplasia, Focal       |                                     2                 3                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                2                                                         |      2  2.0|
      Metaplasia, Diffuse, Osseous         |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |       4                    4                             2     2         |      6  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Re Cell                 |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |          3                                                              4|      4  3.0|
      Pancreatic, Hemorrhage               |                                                                         4|      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5|            |
                                           | 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Plasma Cell             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hemorrhage                           |          2                                                              4|      3  2.3|
      Hyperplasia, Plasma Cell             |                            2                                             |      1  2.0|
      Hyperplasia, Re Cell                 |          2     2                                                     2   |      4  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma, Multifocal                |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |       4                    3                                             |      5  2.4|
      Hyperplasia, Multifocal, Reticulum   |                                                                          |            |
          Cell                             |                                           2                              |      1  2.0|
      Pigmentation, Hemosiderin            |             1                       2           2  3  2                  |     11  2.2|
      Capsule, Ectopic Tissue              |                                        X                                 |      1     |
      Capsule, Infiltration Cellular,      |                                                                          |            |
          Multifocal, Lymphocyte           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  M  +  M  +  M  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +|  38        |
      Ectopic Parathyroid Gland            |                                                                          |      1     |
      Hyperplasia, Diffuse, Tubular        |                                                       2                  |      6  2.2|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |    4                                                                     |      1  4.0|
      Artery, Mediastinum, Inflammation,   |                                                                          |            |
           Chronic Active, Multifocal      |                                     4                                    |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectasia, Focal                       |    2                       2                                             |      2  2.0|
      Ectasia, Multifocal                  |          2              2     2     2                    1               |     12  2.0|
      Hyperplasia, Diffuse                 | 2           1        2                       2  2              3         |     14  1.8|
      Hyperplasia, Focal                   |                                           2                              |      1  2.0|
      Hyperplasia, Multifocal              |                                     2                 1  1               |      4  1.5|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                  2                                       |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperostosis                         |                      3                                                   |      1  3.0|
      Osteopetrosis                        |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5|            |
                                           | 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                      X        X     X  X                                 |     11     |
      Hemorrhage, Focal                    |                               3                                          |      2  2.0|
      Hemorrhage, Multifocal               |                                                             4            |      1  4.0|
      Hydrocephalus                        |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  4.0|
      Inflammation, Chronic, Focal         |                                                                          |      4  2.8|
      Inflammation, Chronic Active, Focal  |          3     3                                      2  3  3  3         |     10  2.6|
      Submucosa, Dilatation, Multifocal    |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Autolysis                            |                                                                          |      1  3.0|
      Hemorrhage, Acute, Multifocal        |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                                                    2                     |      2  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
      Peribronchial, Hyperplasia, Lymphoid,|                                                                          |            |
           Multifocal                      |       2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Exudate                       |    1                                                                     |      1  1.0|
      Lumen, Foreign Body                  |    1                                                                     |      2  2.5|
      Mucosa, Inflammation, Chronic        |                                                          1               |      2  2.5|
      Mucosa, Inflammation, Chronic Active |    1                                                                     |      1  1.0|
      Mucosa, Metaplasia, Focal            |                                                                          |      1  3.0|
      Mucosa, Thrombosis, Multifocal       |                                                                         3|      2  3.0|
      Nasolacrimal Duct, Exudate           |                                                             1  1        1|      5  1.4|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         | 1           1        1              3           1     2  1        1  1   |     13  1.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                             3  2        1|      5  2.2|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Eosinophil                      |                   1                                                      |      2  1.5|
      Respiratory Epithelium, Hyperplasia  | 2     1           1           1                             1            |      7  1.3|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Multifocal                      |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5|            |
                                           | 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                             +            |   2        |
      Cataract                             |                                                             3            |      1  3.0|
      Retina, Degeneration                 |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 4  3  2  3  4     4  2  3  3  3  3  2  2  4  2  4  2  3  2     3  3  1  2|     46  2.7|
      Pigmentation, Diffuse                |                      3           4           3  3                       2|      8  2.5|
      Pigmentation, Multifocal             |                   1                                2     2     1         |     11  1.6|
      Cortex, Cyst                         |                                                                          |      1     |
      Cortex, Hyperplasia, Atypical, Focal |             3     2                                                      |      2  2.5|
      Cortex, Inflammation, Focal,         |                                                                          |            |
          Suppurative                      |                                                       1                  |      1  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Necrosis, Multifocal            |                      2                                                  2|      2  2.0|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization, Focal            |                                     2                                    |      1  2.0|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization, Multifocal       |          2                                      3  2                     |      3  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|             
                                           | 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Parasite Metazoan                    |                      X     X        X                                X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X                                X  X     X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           X                       X      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Fibrosis, Focal          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                3  2      |             
      Angiectasis, Multifocal              |                3                                                         |             
      Basophilic Focus                     |             X                          X           X     X     X        X|             
      Basophilic Focus, Multiple           | X  X              X  X     X                          X     X     X      |             
      Cytomegaly, Multifocal               |                                                                          |             
      Cytoplasmic Alteration, Focal        |                2                                                         |             
      Fatty Change, Focal                  |                            2                                         2   |             
      Fatty Change, Multifocal             |                1                                                         |             
      Granuloma, Multifocal                |             1                          2  3              2     2        1|             
      Hemorrhage, Acute, Multifocal        |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X              X                                               X      |             
      Hyperplasia, Multifocal, Nodular     |                                                 1                        |             
      Inflammation, Chronic, Multifocal    |             2                                                            |             
      Mitotic Alteration                   |                                                                          |             
      Mixed Cell Focus                     |                                                          X              X|             
      Mixed Cell Focus, Two                |                                                       X                  |             
      Necrosis, Multifocal                 |                                     1           2     2                  |             
      Bile Duct, Hyperplasia, Multifocal   |                   1                             3                        |             
      Centrilobular, Fatty Change, Diffuse |       4                       4     3                                    |             
      Centrilobular, Fatty Change,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Centrilobular, Necrosis, Diffuse     |       2                                                                  |             
      Centrilobular, Necrosis, Multifocal  |                               1                                          |             
      Portal, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Artery, Inflammation, Multifocal,    |                                                                          |             
           Necrotizing                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|             
                                           | 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Fat, Inflammation, Focal, Necrotizing|                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Acinus, Atrophy, Focal               |                                                                      2   |             
      Acinus, Atrophy, Multifocal          | 2     2                    3     2                       2               |             
      Duct, Cyst, Multiple                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Mucosa, Palate, Inflammation,        |                                                                          |             
          Chronic, Diffuse                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Parotid Gland, Inflammation, Chronic |                                                                          |             
          Active, Focal                    |                                                                1         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                       +                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic, Diffuse                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3  2     3  2  1  3  2  2  2  1  1  3     2  2  1  2     2  1  1  2  2  2|             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Focal                           |                                                                          |             
      Atrium Left, Thrombosis              |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active, Focal                    |                                                                          |             
      Myocardium, Degeneration, Focal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Capsule, Fibrosis,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |    X                          X        X                       X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                3                                                        2|             
      Atrophy                              |                                                                          |             
      Congestion                           |    2                                                                     |             
      Degeneration, Diffuse, Fatty         |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|             
                                           | 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Degeneration, Fatty, Focal           |                   2                 2                 4           2  3   |             
      Degeneration, Fatty, Multifocal      |       3                                                                  |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Hypertrophy, Multifocal              | 3                                                                        |             
      Pigmentation, Diffuse, Hemosiderin   |                                                                          |             
      Pigmentation, Hemosiderin, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  M  +  +  +  +|             
      Angiectasis, Multifocal              |                3                                                         |             
      Hyperplasia, Focal                   | 1           2                 2                          2               |             
      Hyperplasia, Multifocal              |                                                                      2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |    1  3           2                                                      |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                                                                         2|             
      Pars Distalis, Concretion            |                                                                          |             
      Pars Distalis, Cyst                  |                   3                 4                                    |             
      Pars Distalis, Hyperplasia, Focal    |                                                                         3|             
      Pars Distalis, Hyperplasia           |                                                       3                  |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Pars Nervosa, Pigmentation, Diffuse  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   X      |             
      C-Cell, Hyperplasia, Focal           |                                                    2                 2   |             
      C-Cell, Hyperplasia, Multifocal      |                   1                 1                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                     2                                    |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |    2                                                                     |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Diffuse                  |    2                                                                     |             
      Cyst                                 |                      X              X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|             
                                           | 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis, Focal                   |                                                    2                     |             
      Cyst                                 |                                                                          |             
      Dilatation                           |                                                                2         |             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Hyperplasia, Diffuse     |                                                    2                     |             
      Epithelium, Hyperplasia, Focal       |    4                                                                     |             
      Lumen, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   4      |             
      Hyperplasia, Megakaryocyte           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Re Cell    |                            2                                             |             
      Mediastinal, Pigmentation, Diffuse,  |                                                                          |             
           Hemosiderin                     |                                                                          |             
      Pancreatic, Pigmentation, Hemosiderin|                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                      3   |             
      Renal, Hyperplasia, Re Cell          |                                                                      3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                      2   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                         3                             4                  |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        3                                 |             
      Hyperplasia, Re Cell                 |                                           2                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      | 2                                                                        |             
      Fibrosis, Multifocal                 |                                                 3                        |             
      Hematopoietic Cell Proliferation     |                                              2                    3      |             
      Pigmentation, Hemosiderin            |             1     2     2              2  2           2              2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +|             
      Hyperplasia, Diffuse, Tubular        | 3              2     3  2        3     2        2           3  2        2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|             
                                           | 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ectasia, Diffuse                     |                                              3                           |             
      Ectasia, Focal                       |    4           4                                                         |             
      Ectasia, Multifocal                  |       3           1  3                    2        3           2  2  3   |             
      Hyperplasia, Diffuse                 | 4  1                 2           3        2     2     3        3  2      |             
      Hyperplasia, Focal                   |                         4                                                |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Squamous         |                                                 4                        |             
      Inflammation, Chronic Active, Focal  |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Osteopetrosis                        |                   4                 3                    3               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Diffuse, Proliferative |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | X     X              X  X  X     X        4     X  X           X         |             
      Hydrocephalus                        |                         3                 2        3                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Papillary        |                                                                          |             
      Inflammation, Acute, Diffuse         |                                                                          |             
      Inflammation, Chronic, Focal         |                                        1                                 |             
      Inflammation, Chronic Active, Focal  | 2                 1  1              2                                    |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis, Focal                   |                                                                         1|             
      Inflammation, Chronic, Multifocal    |                            3                                             |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                    3                     |             
      Bronchiole, Alveolus, Inflammation,  |                                                                          |             
           Acute, Multifocal               |                                                       3                  |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                          |             
      Pleura, Inflammation, Multifocal,    |                                                                          |             
           Subacute                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                                                                          |             
      Lumen, Foreign Body                  |                                                                          |             
      Mucosa, Inflammation, Acute          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|             
                                           | 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Inflammation, Chronic        |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                                                                1         |             
      Nasolacrimal Duct, Exudate           |       3     1                                                            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         | 1  2           1        1                 1     2  1           1        1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |       3                                                                  |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Cyst           | 2     1        2  1        1     1                 1              1      |             
      Olfactory Epithelium, Erosion        |                      2                 2                 2               |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Eosinophil                      |       2     1              1        2     1        2                    1|             
      Respiratory Epithelium, Cyst         | 1                          1           1                                 |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Eosinophil                      |             1                       2              1                     |             
      Respiratory Epithelium, Hyperplasia  | 1              2        3                       1        2     3        1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +           +        +         |             
      Cataract                             |                                           4                              |             
      Bilateral, Cataract                  |                                                                3         |             
      Retina, Degeneration                 |                                           4                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                              |             
      Inflammation, Chronic, Multifocal    |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy, Chronic                 | 2  3  2     2  4  2  1  3  1  1  3  1  3  3  1        3  3  3     1  4  2|             
      Pigmentation, Diffuse                |       3              2              2           3     2     2            |             
      Pigmentation, Multifocal             |                         3                 1        2                     |             
      Bilateral, Hydronephrosis            |                                                                   2      |             
      Cortex, Hyperplasia, Atypical, Focal |    1                                                                     |             
      Cortex, Mineralization, Multifocal   |                                                                          |             
      Corticomedullary Junction,           |                                                                          |             
          Mineralization, Multifocal       |                               1                                          |             
      Pelvis, Inflammation, Diffuse,       |                                                                          |             
          Suppurative                      |                                                                      3   |             
      Transitional Epithelium, Hyperplasia |       2                                                                  |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization, Focal            |                                                                          |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization, Multifocal       |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|             
                                           | 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 3                                                              4         |             
      Inflammation, Chronic, Diffuse       |                                                                      2   |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                                          |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7|            |
                             DAY ON TEST   | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2|            |
                                           | 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|  46        |
      Inflammation, Chronic                | 1                                                                        |      1  1.0|
      Parasite Metazoan                    |                                  X           X                    X     X|      8     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |             X                          X           X        X  X         |      9     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                                                                         X|      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Muscularis, Fibrosis, Focal          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                           2                              |      3  2.3|
      Angiectasis, Multifocal              |                                                                          |      1  3.0|
      Basophilic Focus                     |                                              X                           |      7     |
      Basophilic Focus, Multiple           |       X                             X  X                    X     X     X|     14     |
      Cytomegaly, Multifocal               | 1                                                                        |      1  1.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Fatty Change, Focal                  |                                                                          |      2  2.0|
      Fatty Change, Multifocal             | 1  2              1                                                      |      4  1.3|
      Granuloma, Multifocal                | 1     2           1  1  2                 1  1                       4   |     14  1.7|
      Hemorrhage, Acute, Multifocal        |                                  2                                       |      1  2.0|
      Hepatodiaphragmatic Nodule           |    X           X                 X                                       |      6     |
      Hyperplasia, Multifocal, Nodular     |                            3                                             |      2  2.0|
      Inflammation, Chronic, Multifocal    |                                                                          |      1  2.0|
      Mitotic Alteration                   |                            3                                             |      1  3.0|
      Mixed Cell Focus                     |                               X                                          |      3     |
      Mixed Cell Focus, Two                |                                                                          |      1     |
      Necrosis, Multifocal                 |    2           3                                                         |      5  2.0|
      Bile Duct, Hyperplasia, Multifocal   |             2                    3              2  2                     |      6  2.2|
      Centrilobular, Fatty Change, Diffuse |                                  4              3                        |      5  3.6|
      Centrilobular, Fatty Change,         |                                                                          |            |
          Multifocal                       |                                                       2                  |      1  2.0|
      Centrilobular, Necrosis, Diffuse     |                                                                          |      1  2.0|
      Centrilobular, Necrosis, Multifocal  |                                  2              2                        |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7|            |
                             DAY ON TEST   | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2|            |
                                           | 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Portal, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +                    +     +        +                              |   5        |
      Artery, Inflammation, Multifocal,    |                                                                          |            |
           Necrotizing                     |                                           4                              |      1  4.0|
      Fat, Inflammation, Focal, Necrotizing|                                           4                              |      1  4.0|
      Fat, Necrosis, Focal                 |    3  3                    3     3                                       |      4  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Focal, Granulomatous   |                                                                1         |      1  1.0|
      Acinus, Atrophy, Focal               |                                        2                                 |      2  2.0|
      Acinus, Atrophy, Multifocal          |                            2                          2           3      |      8  2.3|
      Duct, Cyst, Multiple                 |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                +         |   1        |
      Mucosa, Palate, Inflammation,        |                                                                          |            |
          Chronic, Diffuse                 |                                                                4         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +|  47        |
      Parotid Gland, Inflammation, Chronic |                                                                          |            |
          Active, Focal                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |    3                                                                     |      1  3.0|
      Epithelium, Hyperplasia              |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                    +                     |   1        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic, Diffuse                |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1     2        3  2  2  2  2  1     1     3  2  2  2  2     1  1     2  1|     40  1.9|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |                                        3                                 |      1  3.0|
      Atrium Left, Thrombosis              |                                  3              2                        |      2  2.5|
      Epicardium, Inflammation, Chronic    |                                                                          |            |
          Active, Focal                    |                                                                   2      |      1  2.0|
      Myocardium, Degeneration, Focal      |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7|            |
                             DAY ON TEST   | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2|            |
                                           | 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Capsule, Fibrosis,        |                                                                          |            |
          Multifocal                       | 2                                                                        |      1  2.0|
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                 X                        |      5     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Multifocal              |             3     3                                                      |      4  2.8|
      Atrophy                              |                                                 2                        |      1  2.0|
      Congestion                           |                                        2                                 |      2  2.0|
      Degeneration, Diffuse, Fatty         |                                                                          |      1  3.0|
      Degeneration, Fatty, Focal           |                                        3  1        4                     |      8  2.6|
      Degeneration, Fatty, Multifocal      |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                              3                          1|      2  2.0|
      Hyperplasia, Multifocal              |                                     2                                    |      1  2.0|
      Hypertrophy, Focal                   |                            2                                             |      1  2.0|
      Hypertrophy, Multifocal              |                                                                          |      1  3.0|
      Pigmentation, Diffuse, Hemosiderin   |                                  2                                       |      1  2.0|
      Pigmentation, Hemosiderin, Multifocal|             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  45        |
      Angiectasis, Multifocal              |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                      2                                                   |      5  1.8|
      Hyperplasia, Multifocal              |                            2     1                                       |      3  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                   2                                                      |      4  2.0|
      Hypertrophy, Focal                   |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis, Focal    |                                              3                           |      2  2.5|
      Pars Distalis, Concretion            |                                                 2                        |      1  2.0|
      Pars Distalis, Cyst                  |                X           2        2  3  2     X  2     3               |     10  2.6|
      Pars Distalis, Hyperplasia, Focal    |                                        2                                 |      2  2.5|
      Pars Distalis, Hyperplasia           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                                     2                                    |      1  2.0|
      Pars Nervosa, Pigmentation, Diffuse  |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      C-Cell, Hyperplasia, Focal           |       2                                                                  |      3  2.0|
      C-Cell, Hyperplasia, Multifocal      |                         1  2        2                 2              2   |      7  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7|            |
                             DAY ON TEST   | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2|            |
                                           | 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Atrophy                              |                                  3                                       |      1  3.0|
      Ectasia                              | 3                       3                                         3      |      4  2.8|
      Hyperplasia                          |                                              4  3  4                     |      3  3.7|
      Inflammation, Acute                  | 2                                                                        |      1  2.0|
      Inflammation, Chronic Active         |                         2                                                |      2  2.0|
      Inflammation, Granulomatous          |                   2  2                                                  3|      3  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion, Diffuse                  |                                                                          |      1  2.0|
      Cyst                                 |       X                                                                  |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenomyosis, Focal                   |                                                                          |      1  2.0|
      Cyst                                 |                                                    1                     |      1  1.0|
      Dilatation                           |                                                       3                  |      2  2.5|
      Inflammation, Chronic Active         |                                                       4                  |      1  4.0|
      Epithelium, Hyperplasia, Diffuse     |                                                                          |      1  2.0|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  4.0|
      Lumen, Hemorrhage                    |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  4.0|
      Hyperplasia, Megakaryocyte           | 3                                                                        |      1  3.0|
      Hyperplasia                          |                                        2  3                              |      2  2.5|
      Myeloid Cell, Hyperplasia            |                                                    2                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Hemorrhage              |                   3           3              3                           |      3  3.0|
      Mediastinal, Hyperplasia, Re Cell    |                                                                          |      1  2.0|
      Mediastinal, Pigmentation, Diffuse,  |                                                                          |            |
           Hemosiderin                     |                                                             3            |      1  3.0|
      Pancreatic, Pigmentation, Hemosiderin|                                                    3                     |      1  3.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
      Renal, Hyperplasia, Re Cell          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Edema                                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7|            |
                             DAY ON TEST   | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2|            |
                                           | 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                3         |      1  3.0|
      Hyperplasia, Plasma Cell             |                      2                                         3  3      |      5  3.0|
      Hyperplasia, Re Cell                 |                                                             2            |      1  2.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
      Hemorrhage                           |                   3                                                      |      2  3.0|
      Hyperplasia, Re Cell                 |                                        2                          2      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                                                 3                        |      2  2.5|
      Fibrosis, Multifocal                 |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     | 2     2        2                                                         |      5  2.2|
      Pigmentation, Hemosiderin            |                   2     2     2                       3     2  3  2      |     15  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  M  +  +  +  +  +  M  M  M  M|  37        |
      Hyperplasia, Diffuse, Tubular        |    2  3                       2           2                              |     14  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia, Diffuse                     |                                                                          |      1  3.0|
      Ectasia, Focal                       |                                                                          |      2  4.0|
      Ectasia, Multifocal                  | 2  3              2  2        2                 2                 1      |     15  2.2|
      Hyperplasia, Diffuse                 | 3  2     3              4                          2                 2   |     15  2.5|
      Hyperplasia, Focal                   |                                        2                                 |      2  3.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Squamous         |                                                                          |      1  4.0|
      Inflammation, Chronic Active, Focal  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                            2           2                                 |      2  2.0|
      Osteopetrosis                        |    2  3                                                                  |      5  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                +         |   1        |
      Inflammation, Diffuse, Proliferative |                                                                4         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          | X        X        X     X     X                       X                  |     16  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7|            |
                             DAY ON TEST   | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2|            |
                                           | 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydrocephalus                        | 2                 2                                                      |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  M  +  M  +|  40        |
      Hyperplasia, Focal, Papillary        |       2                                                                  |      1  2.0|
      Inflammation, Acute, Diffuse         |                   2                                                      |      1  2.0|
      Inflammation, Chronic, Focal         |       2                    2                                             |      3  1.7|
      Inflammation, Chronic Active, Focal  |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atelectasis, Focal                   |                                                                          |      1  1.0|
      Inflammation, Chronic, Multifocal    |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Bronchiole, Alveolus, Inflammation,  |                                                                          |            |
           Acute, Multifocal               |                                                                          |      1  3.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                        3                                 |      1  3.0|
      Pleura, Inflammation, Multifocal,    |                                                                          |            |
           Subacute                        |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Exudate                       |                      1           2                                       |      2  1.5|
      Lumen, Foreign Body                  |                                                                   1      |      1  1.0|
      Mucosa, Inflammation, Acute          |                                  4                                       |      1  4.0|
      Mucosa, Inflammation, Chronic        |                               1                                          |      1  1.0|
      Mucosa, Inflammation, Chronic Active |                1                             1           1               |      4  1.0|
      Nasolacrimal Duct, Exudate           |                2                 1                                       |      4  1.8|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         | 1           2              2        1        1  1  1                     |     16  1.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                   1     3        2                                       |      4  2.3|
      Olfactory Epithelium, Atrophy        |          1        1                                         1            |      3  1.0|
      Olfactory Epithelium, Cyst           | 1           1                       2                 1           1      |     13  1.2|
      Olfactory Epithelium, Erosion        |                      1                                                   |      4  1.8|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Eosinophil                      |    2     1  1     3  1     2        3  1  1              1  3  1  1     2|     21  1.6|
      Respiratory Epithelium, Cyst         | 1           1           1                 1     1  1           1         |     10  1.0|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Eosinophil                      |                                                                          |      3  1.3|
      Respiratory Epithelium, Hyperplasia  |    1              1           1     1  1     3  1     1  2               |     16  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7|            |
                             DAY ON TEST   | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2|            |
                                           | 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                             +                                          |   5        |
      Cataract                             |                                                                          |      1  4.0|
      Bilateral, Cataract                  |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |   2        |
      Inflammation, Chronic, Multifocal    | 1                                                                        |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                              2                           |      1  2.0|
      Nephropathy, Chronic                 | 4  3  1  1  3     3  3  4  1  2  2  1  2  2  4     2  3  2  2  2  2     2|     43  2.3|
      Pigmentation, Diffuse                |             3              3     3              3  2                     |     11  2.5|
      Pigmentation, Multifocal             |    2                                         2                       2   |      6  2.0|
      Bilateral, Hydronephrosis            |                                                                          |      1  2.0|
      Cortex, Hyperplasia, Atypical, Focal |                                                                          |      1  1.0|
      Cortex, Mineralization, Multifocal   |                3                                                         |      1  3.0|
      Corticomedullary Junction,           |                                                                          |            |
          Mineralization, Multifocal       |                                                                          |      1  1.0|
      Pelvis, Inflammation, Diffuse,       |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia | 1  2                                                                     |      3  1.7|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization, Focal            |                                     1                                    |      1  1.0|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization, Multifocal       | 1  2                                                                     |      3  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  M  +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Ectasia                              |                                                                          |      2  3.5|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                        1                                 |      1  1.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                                                 3                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 4| 9| 3| 3| 9| 5| 1| 3| 9| 3| 3| 3| 3| 0| 9| 3| 3| 2| 3| 3|             
                                           | 1| 1| 1| 1| 1| 8| 5| 1| 1| 9| 9| 4| 1| 3| 1| 1| 1| 1| 3| 6| 0| 0| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +  +        +                                      +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +  +        +                                      +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +  M        +                                      M      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +  +        +                                      +      |             
      Parasite Metazoan                    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +  +        +                                      +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +  +        +                                      +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +  +        +                                      +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +  A        +                                      +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +  A        +                                      +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +  +     +  +     +     +  +        +  +   |             
      Angiectasis, Multifocal              |                                                                      3   |             
      Basophilic Focus                     |                X                                                         |             
      Basophilic Focus, Multiple           | X  X     X  X        X  X                       X                        |             
      Congestion, Acute, Multifocal        |                                                                      3   |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Multifocal             |                                  2                                       |             
      Granuloma, Multifocal                |                         2                       2        2               |             
      Hepatodiaphragmatic Nodule           |    X                    X                                                |             
      Hepatodiaphragmatic Nodule, Multiple |                                                          X               |             
      Hyperplasia, Focal, Nodular          |                                  2                                       |             
      Mitotic Alteration                   |                                                                      2   |             
      Necrosis, Focal                      |                                                                      1   |             
      Necrosis, Multifocal                 |                                        2                                 |             
      Pigmentation, Multifocal             |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |                               2  2                                2      |             
      Centrilobular, Atrophy, Multifocal   |                                           3                              |             
      Centrilobular, Degeneration, Diffuse |                               2                                   2      |             
      Centrilobular, Degeneration,         |                                                                          |             
          Multifocal                       |                                  2                                       |             
      Centrilobular, Fatty Change, Diffuse |                            3           3                                 |             
      Periportal, Fatty Change, Multifocal | 2                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +  +        +              +                       +     +|             
      Acinus, Atrophy, Multifocal          |                1                          2                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +  +        +                                      +      |             
                                            __________________________________________________________________________|             
   Stomach                                 |                +  +        +                                      +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +  +        +                                      +      |             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +  +        +                                      +      |             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 4| 9| 3| 3| 9| 5| 1| 3| 9| 3| 3| 3| 3| 0| 9| 3| 3| 2| 3| 3|             
                                           | 1| 1| 1| 1| 1| 8| 5| 1| 1| 9| 9| 4| 1| 3| 1| 1| 1| 1| 3| 6| 0| 0| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +     +  +        +                                      +      |             
      Cardiomyopathy                       |                2                                                         |             
      Atrium Left, Thrombosis              |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +     +  +        +                                      +     +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +     +  +        +                                      +     +|             
      Angiectasis, Multifocal              |                                                                         2|             
      Congestion                           |                   3                                                      |             
      Degeneration, Fatty, Focal           |                                                                          |             
      Degeneration, Fatty, Multifocal      | 2                                                                        |             
      Hyperplasia, Multifocal              |                                                                          |             
      Hypertrophy, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +        +     +  +        +                                      +     +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +  +        +              +                       +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +  M        +                                      M      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +        +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                               2                                          |             
      Pars Distalis, Angiectasis,          |                                                                          |             
          Multifocal                       |                                           2                              |             
      Pars Distalis, Cyst                  |       1                          3     3              4           4      |             
      Pars Distalis, Cyst, Multiple        |                                                             4            |             
      Pars Distalis, Hyperplasia, Focal    |                                                                         2|             
      Pars Distalis, Hyperplasia           |                                                                      3   |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +        +           +                          +      |             
      Developmental Malformation           |                                                                          |             
      C-Cell, Hyperplasia, Multifocal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Necrosis, Acute                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +     +     M  M     +  +                                      +      |             
      Abscess                              |                         3                                                |             
      Atrophy                              |    3                                                                     |             
      Ectasia                              |                            3                                             |             
      Hyperplasia                          |          4                                                               |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 4| 9| 3| 3| 9| 5| 1| 3| 9| 3| 3| 3| 3| 0| 9| 3| 3| 2| 3| 3|             
                                           | 1| 1| 1| 1| 1| 8| 5| 1| 1| 9| 9| 4| 1| 3| 1| 1| 1| 1| 3| 6| 0| 0| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |          +  +  +  +  +     +     +  +                             +      |             
      Cyst                                 |          X                       3  4                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  |             +  +  +        +                 +              +  +  +      |             
      Dilatation                           |                3                                                         |             
      Lumen, Hemorrhage                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +  +        +                                      +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +           +  +        +                          +  +  +     +      |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Inflammation, Acute      |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +              M  +        +                                      +      |             
      Hyperplasia, Re Cell                 |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +           +  +        M                             +  +     +      |             
      Hemorrhage                           | 2  2                                                        2            |             
      Pigmentation, Hemosiderin            |                   2                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +        +  +  +        +           +           +      |             
      Fibrosis, Focal                      |                                           4                              |             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +  +        +                                      M      |             
      Ectopic Parathyroid Gland            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +  +  +           +              +     +     M      |             
      Ectasia, Diffuse                     | 3                                                                        |             
      Ectasia, Multifocal                  |          1  2     2  2  3  3           2                                 |             
      Galactocele                          |             4                                                            |             
      Hyperplasia, Diffuse                 |    2                 2     3           2              2                  |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +           +  +        +              +                       +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +  +        +                                      +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +  +        +  +                                   +      |             
      Compression                          |                                                                          |             
      Hemorrhage, Multifocal               |                   3                                                      |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                +  +        +                                      M      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 4| 9| 3| 3| 9| 5| 1| 3| 9| 3| 3| 3| 3| 0| 9| 3| 3| 2| 3| 3|             
                                           | 1| 1| 1| 1| 1| 8| 5| 1| 1| 9| 9| 4| 1| 3| 1| 1| 1| 1| 3| 6| 0| 0| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Granuloma, Multifocal                |                                                                         1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |             1                                3                           |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |          2                                                               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |          2                             1                                 |             
      Mucosa, Inflammation, Chronic        |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                                                 1                    1   |             
      Mucosa, Thrombosis, Multifocal       |                               4        4                          1      |             
      Nasolacrimal Duct, Exudate           |                               2                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |          3  2        1                                2  1           2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                               3                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Cyst           |                1                                1  1           1  1      |             
      Olfactory Epithelium, Erosion        |          1  1                                                            |             
      Olfactory Epithelium, Exudate        |                                                                          |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Eosinophil                      |             2                    1  1                          1         |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Cyst         |    1                    1                                   1            |             
      Respiratory Epithelium, Hyperplasia  |       2     1                    1  1  1     1     1  1        1     1   |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +  M        +                                      +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                          +                                          |             
      Bilateral, Cataract                  |                                                                          |             
      Bilateral, Retina, Degeneration      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +              +  +        +           +              +           +      |             
      Nephropathy, Chronic                 | 4                                                     2                  |             
      Pigmentation, Diffuse                |                                                       3                  |             
      Pigmentation, Multifocal             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +  +        +                                      +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 7| 5| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 2| 0| 2| 2| 0| 2| 7| 3| 3| 2| 0| 6| 2| 2| 2| 8| 3| 3| 2| 2|            |
                                           | 4| 0| 1| 9| 9| 4| 7| 8| 8| 9| 8| 5| 0| 0| 9| 7| 0| 9| 6| 8| 3| 7| 7| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +              +                                +     +     +            |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +              +                                +     +     +  +         |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +              +                                +     M                  |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +              +                                +     +     +  +         |  10        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +              +                                +     +     +            |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +              +                                +     +     +            |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +              +                                +     +     +            |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | M              +                                +     +     +            |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +              +                                +     M     +            |   7        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +        +     +        +  +  +  +  +  +  +            |  33        |
      Angiectasis, Multifocal              |                                              3                           |      2  3.0|
      Basophilic Focus                     | X  X                                                                     |      3     |
      Basophilic Focus, Multiple           |             X                                               X            |      9     |
      Congestion, Acute, Multifocal        |                                           2        2                     |      3  2.3|
      Fatty Change, Diffuse                |                   4                                                      |      1  4.0|
      Fatty Change, Multifocal             |                                                                          |      1  2.0|
      Granuloma, Multifocal                |    2        1                             3                              |      6  2.0|
      Hepatodiaphragmatic Nodule           |       X     X                                X                           |      5     |
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |      1     |
      Hyperplasia, Focal, Nodular          |                                                          2               |      2  2.0|
      Mitotic Alteration                   |                                                                          |      1  2.0|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Necrosis, Multifocal                 |                                                                          |      1  2.0|
      Pigmentation, Multifocal             |                                           2                              |      1  2.0|
      Bile Duct, Hyperplasia, Multifocal   |                2           2                          2  2               |      7  2.0|
      Centrilobular, Atrophy, Multifocal   |                                                                          |      1  3.0|
      Centrilobular, Degeneration, Diffuse |                                  2                    3                  |      4  2.3|
      Centrilobular, Degeneration,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Centrilobular, Fatty Change, Diffuse |                                                          4               |      3  3.3|
      Periportal, Fatty Change, Multifocal |                                           2                              |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                +         |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +              +                                +     +  +  +  +         |  13        |
      Acinus, Atrophy, Multifocal          |                                                             1            |      3  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +              +                                +     +     +            |   9        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +              +                                +     +  +  +           +|  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +              +                                +     +  +  +           +|  11        |
      Inflammation, Chronic Active         |                                                          4               |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 7| 5| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 2| 0| 2| 2| 0| 2| 7| 3| 3| 2| 0| 6| 2| 2| 2| 8| 3| 3| 2| 2|            |
                                           | 4| 0| 1| 9| 9| 4| 7| 8| 8| 9| 8| 5| 0| 0| 9| 7| 0| 9| 6| 8| 3| 7| 7| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Hyperplasia              |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +              +                                +     +  +  +           +|  11        |
      Cyst Epithelial Inclusion            |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +              +                                +     +     +            |  10        |
      Cardiomyopathy                       | 1                                                     1     1            |      4  1.3|
      Atrium Left, Thrombosis              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +        +                                +  +  +     +            |  14        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                       X                  |      1     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +        +                                +  +  +     +            |  14        |
      Angiectasis, Multifocal              |                                                 3  2                     |      3  2.3|
      Congestion                           |                                                                          |      1  3.0|
      Degeneration, Fatty, Focal           |                                                             4            |      1  4.0|
      Degeneration, Fatty, Multifocal      |                                                                          |      1  2.0|
      Hyperplasia, Multifocal              |       3                                                                  |      1  3.0|
      Hypertrophy, Multifocal              |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +        +                                +  +  +     +            |  14        |
      Hyperplasia, Focal                   |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +              +                                +     +  +  +            |  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +              +                                +     +     +            |   7        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +  +  +  +  +|  43        |
      Pars Distalis, Angiectasis, Focal    |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis,          |                                                                          |            |
          Multifocal                       |                                                       2                 3|      3  2.3|
      Pars Distalis, Cyst                  |                      2  2           2                 2     3            |     10  2.6|
      Pars Distalis, Cyst, Multiple        |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia, Focal    |                         2                                                |      2  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +              +                                +     +     +            |  10        |
      Developmental Malformation           |                                                       X                  |      1     |
      C-Cell, Hyperplasia, Multifocal      |                                                       1                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 7| 5| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 2| 0| 2| 2| 0| 2| 7| 3| 3| 2| 0| 6| 2| 2| 2| 8| 3| 3| 2| 2|            |
                                           | 4| 0| 1| 9| 9| 4| 7| 8| 8| 9| 8| 5| 0| 0| 9| 7| 0| 9| 6| 8| 3| 7| 7| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                             +            |   1        |
      Necrosis, Acute                      |                                                             4            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +        +                          +     M     +     M            |  11        |
      Abscess                              |                                                                          |      1  3.0|
      Atrophy                              |                                                                          |      1  3.0|
      Ectasia                              |                                                       2                  |      2  2.5|
      Hyperplasia                          |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +        +        +                    +  +  +  +     +            |  18        |
      Cyst                                 |       4                                      4                           |      5  3.8|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +              +        +  +  +     +           +     +  +  +            |  18        |
      Dilatation                           |                                                       2     4            |      3  3.0|
      Lumen, Hemorrhage                    |                            4                                             |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +              +                                +     +     +            |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +              +                 +              +     +  +  +  +         |  17        |
      Pancreatic, Hemorrhage               |                                  2                                       |      1  2.0|
      Pancreatic, Inflammation, Acute      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +              +                 +              +     +     +  +         |  11        |
      Hyperplasia, Re Cell                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +              +                                +     +     +            |  12        |
      Hemorrhage                           |                                                                          |      3  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +              +  +        +     +              +  +  +  +  +  +         |  19        |
      Fibrosis, Focal                      |                                                                          |      1  4.0|
      Metaplasia, Focal, Osseous           |                                  3                                       |      1  3.0|
      Pigmentation, Hemosiderin            |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +              M                                M     +     +            |   6        |
      Ectopic Parathyroid Gland            |                                                       X     X            |      2     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +     +  +     +     +  +        +  +  +  +  +  +  +           +|  29        |
      Ectasia, Diffuse                     |                2                                      2                  |      3  2.3|
      Ectasia, Multifocal                  |       4                          2           4                           |     10  2.5|
      Galactocele                          |                                                                          |      1  4.0|
      Hyperplasia, Diffuse                 |    1           2                          2     2  3                    2|     11  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 7| 5| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 2| 0| 2| 2| 0| 2| 7| 3| 3| 2| 0| 6| 2| 2| 2| 8| 3| 3| 2| 2|            |
                                           | 4| 0| 1| 9| 9| 4| 7| 8| 8| 9| 8| 5| 0| 0| 9| 7| 0| 9| 6| 8| 3| 7| 7| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Focal                   |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +              +                                +     +     +     +     +|  13        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +              +                                +     +     +            |   9        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +              +                          +     +     +     +            |  11        |
      Compression                          |                                           X                              |      1     |
      Hemorrhage, Multifocal               |                                                                          |      1  3.0|
      Hydrocephalus                        |                                           2                              |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +              +                                +           M            |   6        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma, Multifocal                |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |             2           2              2                                 |      5  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               |             1                                                            |      1  1.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                                         1|      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lumen, Exudate                       |    3                 1                                                   |      4  1.8|
      Mucosa, Inflammation, Chronic        |                                                             1           1|      2  1.0|
      Mucosa, Inflammation, Chronic Active |    3                                                              1      |      4  1.5|
      Mucosa, Thrombosis, Multifocal       |                                                          3               |      4  3.0|
      Nasolacrimal Duct, Exudate           |                                           2                       1      |      3  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |    1  1  1  1  1  1                    2  3     2                 1  1   |     17  1.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
      Olfactory Epithelium, Atrophy        |                                  1     1                                 |      2  1.0|
      Olfactory Epithelium, Cyst           |                                                                          |      5  1.0|
      Olfactory Epithelium, Erosion        |                      2                                                   |      3  1.3|
      Olfactory Epithelium, Exudate        |                            1                                             |      1  1.0|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 7| 5| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 2| 0| 2| 2| 0| 2| 7| 3| 3| 2| 0| 6| 2| 2| 2| 8| 3| 3| 2| 2|            |
                                           | 4| 0| 1| 9| 9| 4| 7| 8| 8| 9| 8| 5| 0| 0| 9| 7| 0| 9| 6| 8| 3| 7| 7| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Eosinophil                      | 1        1           3                    3                          2   |      9  1.7|
      Olfactory Epithelium, Metaplasia     |    3                                                                     |      1  3.0|
      Respiratory Epithelium, Cyst         |                      1           1                                1      |      6  1.0|
      Respiratory Epithelium, Hyperplasia  | 1  3  2     1  1  1                             1           1  1         |     19  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +              +                                +     +     +            |   8        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   3        |
      Bilateral, Cataract                  | 4                                                                        |      1  4.0|
      Bilateral, Retina, Degeneration      | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +        +                                +     +  +  +            |  14        |
      Nephropathy, Chronic                 |       4        1                                4        3               |      6  3.0|
      Pigmentation, Diffuse                | 2                                                                        |      2  2.5|
      Pigmentation, Multifocal             |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +        +                                +     +     M            |   9        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|             
                                           | 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  M  M  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  M  M     +  +     +  +  +  +  M  M  +  +  +  +  +|             
      Parasite Metazoan                    |                                                             X            |             
      Artery, Submucosa, Inflammation,     |                                                                          |             
           Chronic Active, Multifocal      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  M  +  +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       |                                                                          |             
      Ulcer, Two                           |                                  3                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +     +  +     +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   | 2                 2                                                      |             
      Angiectasis, Multifocal              |                      2                                                  2|             
      Basophilic Focus                     |    X                                                                     |             
      Basophilic Focus, Multiple           |                                                                          |             
      Cytoplasmic Alteration, Focal        | 2                                                              3         |             
      Degeneration, Ballooning, Focal      |                                           2                              |             
      Eosinophilic Focus                   |                                                                         X|             
      Eosinophilic Focus, Multiple         |       X                                                                  |             
      Fatty Change, Diffuse                |                                                    1                     |             
      Fatty Change, Focal                  |                                                             1            |             
      Fatty Change, Multifocal             |                                                                          |             
      Granuloma, Multifocal                |    3           1                                1        1               |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |             2                                                            |             
      Hemorrhage, Multifocal               |          3                                                               |             
      Hepatodiaphragmatic Nodule           | X              X                                                         |             
      Hyperplasia, Multifocal, Nodular     |                                                                          |             
      Necrosis, Multifocal                 |          3              2        3                                   4   |             
      Thrombosis, Two                      |                                                                      X   |             
      Bile Duct, Fibrosis, Multifocal      |                                     2                                    |             
      Bile Duct, Hyperplasia, Multifocal   | 2     2  3     1        4        4  3           2  2     1  3  3     2   |             
      Centrilobular, Congestion, Diffuse   |                                              3                           |             
      Centrilobular, Degeneration, Diffuse |                                                                          |             
      Centrilobular, Fatty Change, Diffuse |                         3        4  3                             3      |             
      Centrilobular, Fatty Change,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Centrilobular, Necrosis, Diffuse     |                                              1        2           3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|             
                                           | 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Centrilobular, Necrosis, Multifocal  |                                                                          |             
      Periportal, Fatty Change, Diffuse    |                                                                          |             
      Portal, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Portal, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                    2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +  +                       +        +   |             
      Hemorrhage, Acute, Multifocal        |                                     4                                    |             
      Artery, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                             4            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                            1                                             |             
      Acinus, Atrophy, Diffuse             | 2                                                                        |             
      Acinus, Atrophy, Focal               |    2                 2                                                  2|             
      Acinus, Atrophy, Multifocal          |       2  2  1           4  2              3  3                       4   |             
      Acinus, Hyperplasia, Multifocal      |                                                                          |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                             3            |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                     +                                    |             
      Palate, Inflammation, Chronic, Focal |                                     2                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          4                       1                 4                 3   |             
      Ulcer                                |          3           4                                               4   |             
      Epithelium, Hyperplasia              |                                  2                 3                 3   |             
      Submucosa, Inflammation, Subacute    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Multiple                       |                                                                          |             
      Mineralization, Multifocal           |                                                    2                     |             
      Ulcer, Acute                         |                         3                                                |             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                       +                           |             
      Pulp, Angiectasis                    |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3  3  3     2  2  2  2  2  3     2  2  3  2  2  2  3  1  2  2  2     2  2|             
      Atrium Left, Thrombosis              |                         3        3                                       |             
      Endocardium, Atrium, Fibrosis, Focal |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|             
                                           | 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Valve, Fibrosis, Focal               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                            X                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Degeneration, Diffuse, Fatty         |          2                          1     1        2              2  3   |             
      Degeneration, Fatty, Focal           |    2                    2           2           2                       3|             
      Degeneration, Fatty, Multifocal      |                                                    2           2         |             
      Hyperplasia, Focal                   |       3                                                                  |             
      Hyperplasia, Multifocal              |                      2           3                                   2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Hyperplasia, Focal                   |                      2  2        2        3                 3            |             
      Hyperplasia, Multifocal              | 2        2        2                 1              3                    2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                  2                                   3   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Diffuse, |                                                                          |             
           Eosinophil                      |                      3                                                   |             
      Pars Distalis, Hyperplasia, Focal    |                         3                                                |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |             2        2                                               2   |             
      Pars Distalis, Pigmentation, Focal   |                         3                                                |             
      Pars Intermedia, Hyperplasia         |                                                                3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                       X                  |             
      Mineralization, Multifocal           |                                                                          |             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      C-Cell, Hyperplasia, Multifocal      |                         4                                                |             
      Follicular Cell, Degeneration,       |                                                                          |             
          Multifocal                       |                                                 1                        |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|             
                                           | 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation, Multifocal               |                                                                      2   |             
      Granuloma Sperm, Single              |                                                                          |             
      Inflammation, Focal, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Atrophy, Diffuse                     |                                                                          |             
      Ectasia                              |             2                                                            |             
      Fibrosis, Diffuse                    |                                                                          |             
      Inflammation, Chronic Active         |             2                                   1                        |             
      Inflammation, Diffuse, Granulomatous |                                                                      2   |             
      Inflammation, Focal, Granulomatous   | 2                                                        2               |             
      Inflammation, Focal, Suppurative     |                2                                                         |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |          3        2     2           2              3           1         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                      1                 1  1                    2         |             
      Hyperplasia, Multifocal              | 2                                                                        |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |             3                                      4     3        2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  M     +  +  +  M     +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Atrophy, Diffuse                     |                                     2                                    |             
      Inflammation, Diffuse, Subacute      |                                                    3                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                |                                              1                           |             
      Mineralization, Multifocal           |                                                                          |             
      Arteriole, Inflammation              |                2                          1     3  3                     |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         |       4  1              1              1           3                     |             
      Seminiferous Tubule, Degeneration    |                                                                          |             
      Serosa, Necrosis, Focal              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             3  2  3                                               3      |             
      Metaplasia, Osseous                  |                                                                          |             
      Myelofibrosis                        |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Suppurative     |                                                                      3   |             
      Lumbar, Inflammation, Granulomatous, |                                                                          |             
           Multifocal                      |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|             
                                           | 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                  2                                       |             
      Mediastinal, Hyperplasia, Re Cell    |                                                                          |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2                                                                        |             
      Hyperplasia, Plasma Cell             |             4                                                            |             
      Hyperplasia, Re Cell                 |                                        3                                 |             
      Inflammation, Focal, Subacute        |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  M     +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Re Cell                 |                                        3                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Fibrosis, Multifocal                 | 2              2                                                         |             
      Hematopoietic Cell Proliferation     |             2                                      1  4                  |             
      Necrosis, Coagulative, Focal         |                                  3                                       |             
      Pigmentation, Hemosiderin            |                                        2                 2               |             
      Capsule, Fibrosis, Multifocal        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +     +  M  +  M  +  +  +  +  +  +  +  M  M  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Tubular                 | 2                                2                 2           3         |             
      Artery, Inflammation, Chronic Active |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  M  +  +  M  M  +  +|             
      Ectasia, Diffuse                     |    3                             3  3              4     2              2|             
      Ectasia, Multifocal                  | 2     2        4  3     3  3           2  1  4  2                    4   |             
      Hyperplasia, Diffuse                 |                3     2                                                   |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                2                                                         |             
      Inflammation, Proliferative          |                   3                                      2               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Artery, Subcutaneous Tissue,         |                                                                          |             
          Inflammation, Chronic Active,    |                                                                          |             
           Focal                           |                                                                          |             
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|             
                                           | 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Chronic, Focal                  |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternum, Developmental Malformation  |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    3  1                    4                    3  X     X              2|             
      Hemorrhage, Focal                    |          4                                         3                     |             
      Hemorrhage, Multifocal               |                                     4                                    |             
      Hydrocephalus                        |                            4                 2                           |             
      Thalamus, Gliosis, Focal             |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  M  +  +  +  +  M     +  +  +  +  M  +  +  M  M  +  +  M  +  +|             
      Inflammation, Chronic Active, Focal  |       3        2        1                                      2     4   |             
      Inflammation, Focal, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema, Focal                         |                                                                          |             
      Hemorrhage, Multifocal, Subacute     |                                                       3                  |             
      Bronchus, Epithelium, Hyperplasia,   |                                                                          |             
           Focal                           |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |                                                             1            |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                          |             
      Vein, Mineralization, Multifocal     |                                              3                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                         2                          1                     |             
      Lumen, Foreign Body                  |                   2                                                      |             
      Mucosa, Inflammation, Chronic        |                                              1  1  2                     |             
      Mucosa, Inflammation, Chronic Active |                   2     2                                                |             
      Mucosa, Thrombosis, Multifocal       |                         4        2                                3      |             
      Nasolacrimal Duct, Exudate           |                                                                          |             
      Nasolacrimal Duct, Hyperplasia       |                                                                         2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         | 2           4           2  3        1        1     1              1      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Eosinophil                      |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|             
                                           | 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Cyst         |                                                                          |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Eosinophil                      |                                     1     2                              |             
      Respiratory Epithelium, Hyperplasia  | 1                       2        1              2  2                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                          +        +                           |             
      Choroid, Left, Hemorrhage            |          4                                                               |             
      Retina, Degeneration                 |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 4  4  3  3  2  4  4  4  1  2     3  3  1  4  3  4  4     4  3  4  2  3  4|             
      Pigmentation, Diffuse                |                                     3                                    |             
      Pigmentation, Multifocal             |                            2                                             |             
      Cortex, Cyst                         |                                                                      2   |             
      Cortex, Hyperplasia, Atypical        |                                                                          |             
      Transitional Epithelium, Hyperplasia |                      3                                                   |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization                   |          1           2           2                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                             X            |             
      Inflammation, Chronic Active, Focal  |                                                    2                     |             
      Lumen, Calculus Micro Observation    |                                                                          |             
          Only, Single                     |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3|            |
                                           | 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +|  43        |
      Parasite Metazoan                    |    X                                                              X      |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +|  46        |
      Parasite Metazoan                    |    X        X                                         X           X      |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  M  M  +  +  +  M  +  +  +  +  +  +     M  +  +  +  +     +  +  +  +  +|  36        |
      Parasite Metazoan                    |             X                                                            |      2     |
      Artery, Submucosa, Inflammation,     |                                                                          |            |
           Chronic Active, Multifocal      |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +|  45        |
      Inflammation, Chronic, Diffuse       |                                              2                           |      1  2.0|
      Ulcer, Two                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis, Focal                   |    2                                                                     |      3  2.0|
      Angiectasis, Multifocal              |                                                 2                        |      3  2.0|
      Basophilic Focus                     |                                                                          |      1     |
      Basophilic Focus, Multiple           |                X                                                         |      1     |
      Cytoplasmic Alteration, Focal        |                                                                          |      2  2.5|
      Degeneration, Ballooning, Focal      |                      2     2                                             |      3  2.0|
      Eosinophilic Focus                   |                                                                          |      1     |
      Eosinophilic Focus, Multiple         |                                                                          |      1     |
      Fatty Change, Diffuse                |                                                                          |      1  1.0|
      Fatty Change, Focal                  |                1                                                         |      2  1.0|
      Fatty Change, Multifocal             |                                  2                                       |      1  2.0|
      Granuloma, Multifocal                |                                                                          |      4  1.5|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Hemorrhage, Multifocal               |                         3                                                |      2  3.0|
      Hepatodiaphragmatic Nodule           |    X                                                                     |      3     |
      Hyperplasia, Multifocal, Nodular     |                                                    4                     |      1  4.0|
      Necrosis, Multifocal                 |    2  2              1  3           2           2     1  2               |     12  2.3|
      Thrombosis, Two                      |                                                                          |      1     |
      Bile Duct, Fibrosis, Multifocal      |                         3                                                |      2  2.5|
      Bile Duct, Hyperplasia, Multifocal   |    4  3  1  4  2     4  3  3     1  3     2  3     4  3     3  2  1  2  3|     32  2.6|
      Centrilobular, Congestion, Diffuse   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3|            |
                                           | 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Centrilobular, Degeneration, Diffuse |    2                                                        3            |      2  2.5|
      Centrilobular, Fatty Change, Diffuse |                      4              3  4              4  4     2     4   |     11  3.5|
      Centrilobular, Fatty Change,         |                                                                          |            |
          Multifocal                       |       3                                                                  |      1  3.0|
      Centrilobular, Necrosis, Diffuse     | 3                                      3                                 |      5  2.4|
      Centrilobular, Necrosis, Multifocal  |                                                                      2   |      1  2.0|
      Periportal, Fatty Change, Diffuse    |                                                 3                        |      1  3.0|
      Portal, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                  1                                       |      1  1.0|
      Portal, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                              2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                    +  +        +        +|   8        |
      Hemorrhage, Acute, Multifocal        |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +|  46        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                              2                           |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                   1                                                      |      2  1.0|
      Acinus, Atrophy, Diffuse             |                                     4              4                     |      3  3.3|
      Acinus, Atrophy, Focal               |             2     1                                                      |      5  1.8|
      Acinus, Atrophy, Multifocal          | 2        1     1        4     3  2              2     2              1  2|     18  2.3|
      Acinus, Hyperplasia, Multifocal      |                      1                                                   |      1  1.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                            2                                             |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Inflammation, Chronic, Focal |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                                      2   |      5  2.8|
      Ulcer                                |                                                                          |      3  3.7|
      Epithelium, Hyperplasia              |                                                 3  3                 3   |      6  2.8|
      Submucosa, Inflammation, Subacute    |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +|  47        |
      Cyst, Multiple                       |       2                                                                  |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3|            |
                                           | 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization, Multifocal           |                                                                          |      1  2.0|
      Ulcer, Acute                         |                                                       2                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Pulp, Angiectasis                    |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy                       | 4     2  3  4  1  1  1  2  2  1  3  2  4        3        2  2  3  2  2  1|     42  2.2|
      Atrium Left, Thrombosis              |                                        3           2                     |      4  2.8|
      Endocardium, Atrium, Fibrosis, Focal |                                              2                           |      1  2.0|
      Valve, Fibrosis, Focal               |                                                                      3   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |       X              X           X                    X                  |      5     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cytoplasmic Alteration, Focal        |                                           2                              |      1  2.0|
      Degeneration, Diffuse, Fatty         |                      2              3  3        2  2  3              3   |     13  2.2|
      Degeneration, Fatty, Focal           |                            2                                             |      6  2.2|
      Degeneration, Fatty, Multifocal      |       1                                                                  |      3  1.7|
      Hyperplasia, Focal                   |          2                          1                             2      |      4  2.0|
      Hyperplasia, Multifocal              |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis, Focal                   |                                                    2                     |      1  2.0|
      Hyperplasia, Focal                   |    2                       2                                            2|      8  2.3|
      Hyperplasia, Multifocal              |                2        1                          2        3            |     10  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +|  46        |
      Atrophy, Diffuse                     |                                                    4                     |      1  4.0|
      Hyperplasia, Focal                   |                                     3                             2      |      2  2.5|
      Hyperplasia                          |                            3                                             |      1  3.0|
      Hyperplasia, Multifocal              |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  45        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                                                          |      2  2.5|
      Pars Distalis, Cyst                  |                         3                                                |      1  3.0|
      Pars Distalis, Hyperplasia, Diffuse, |                                                                          |            |
           Eosinophil                      |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3|            |
                                           | 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hyperplasia, Focal    |          2                                                               |      2  2.5|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                                                    2                 2   |      5  2.0|
      Pars Distalis, Pigmentation, Focal   |                                                                          |      1  3.0|
      Pars Intermedia, Hyperplasia         |             2                                                            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1     |
      Mineralization, Multifocal           |                                        2                                 |      1  2.0|
      C-Cell, Hyperplasia, Focal           |             3                                   3  2                 2   |      4  2.5|
      C-Cell, Hyperplasia, Multifocal      |                2                 2                          2            |      4  2.5|
      Follicular Cell, Degeneration,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia, Focal  |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  47        |
      Dilatation, Multifocal               |                               2                                          |      2  2.0|
      Granuloma Sperm, Single              |                         4                                                |      1  4.0|
      Inflammation, Focal, Suppurative     |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  46        |
      Atrophy, Diffuse                     |                                                    3                     |      1  3.0|
      Ectasia                              |                3                                                         |      2  2.5|
      Fibrosis, Diffuse                    |                         3              4                                 |      2  3.5|
      Inflammation, Chronic Active         |                   3                    3                                 |      4  2.3|
      Inflammation, Diffuse, Granulomatous |                                                                          |      1  2.0|
      Inflammation, Focal, Granulomatous   |       2                       2                                          |      4  2.0|
      Inflammation, Focal, Suppurative     |                                                                          |      1  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |    2     2  2              2     2        3  3  3     2        2     2  2|     18  2.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                      1   |      5  1.2|
      Hyperplasia, Multifocal              |    2                                               1                     |      3  1.7|
      Inflammation, Chronic                |                      2                                                   |      1  2.0|
      Inflammation, Chronic Active         |    2  2                    2  2                                          |      8  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +|  41        |
      Atrophy, Diffuse                     |                         2                                               3|      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3|            |
                                           | 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Diffuse, Subacute      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization, Focal                |                                                                          |      1  1.0|
      Mineralization, Multifocal           |                   2                                                      |      1  2.0|
      Arteriole, Inflammation              |                3                                3                        |      6  2.5|
      Interstitial Cell, Hyperplasia       |    1                                                                 1   |      2  1.0|
      Seminiferous Tubule, Atrophy         |       2     3                    1              3  3  3  4     3         |     13  2.5|
      Seminiferous Tubule, Degeneration    |                2        3                                                |      2  2.5|
      Serosa, Necrosis, Focal              |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |    3                                   4                 3     4         |      8  3.1|
      Metaplasia, Osseous                  |                                                       2                  |      1  2.0|
      Myelofibrosis                        |                                                       3                  |      1  3.0|
      Myeloid Cell, Hyperplasia            |          3        4  3                                                   |      4  3.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Focal, Suppurative     |                                                                          |      1  3.0|
      Lumbar, Inflammation, Granulomatous, |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              | 3                                            4                           |      2  3.5|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Re Cell    |                            3                                             |      1  3.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                        3                       2         |      2  2.5|
      Pancreatic, Hyperplasia, Lymphoid    |                                        3                                 |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|  44        |
      Hyperplasia, Lymphoid                |                                                                2         |      2  2.0|
      Hyperplasia, Plasma Cell             |          3                                                               |      2  3.5|
      Hyperplasia, Re Cell                 |                                                                          |      1  3.0|
      Inflammation, Focal, Subacute        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  44        |
      Depletion Lymphoid                   |                      3                                                   |      1  3.0|
      Hyperplasia, Lymphoid                |                                        3                       2         |      2  2.5|
      Hyperplasia, Re Cell                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis, Focal                      |                                                             3            |      1  3.0|
      Fibrosis, Multifocal                 |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                3         |      4  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3|            |
                                           | 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Necrosis, Coagulative, Focal         |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                  2                                       |      3  2.0|
      Capsule, Fibrosis, Multifocal        |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  M  +  M  +  +  +|  38        |
      Hemorrhage                           | 3                                                                        |      1  3.0|
      Hyperplasia, Tubular                 |             2  3           3  2                                          |      8  2.4|
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  M  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  M  +  M  +  +  +|  38        |
      Ectasia, Diffuse                     |                3                                      3              1   |      9  2.7|
      Ectasia, Multifocal                  |       2              2                          2                        |     14  2.6|
      Hyperplasia, Diffuse                 |                                                             3            |      3  2.7|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |       2                                                                  |      2  2.0|
      Inflammation, Proliferative          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst Epithelial Inclusion            |                                                          X               |      1     |
      Hyperkeratosis                       |                                                 3                        |      1  3.0|
      Hyperplasia, Squamous                |                                                                   2      |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                   2      |      1  2.0|
      Artery, Subcutaneous Tissue,         |                                                                          |            |
          Inflammation, Chronic Active,    |                                                                          |            |
           Focal                           |                            2                                             |      1  2.0|
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |            |
           Chronic, Focal                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Sternum, Developmental Malformation  |                                                    X                     |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                          +     +         |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Compression                          |       X        X                 X              2                        |     11  2.6|
      Hemorrhage, Focal                    |    2                                                                 1   |      4  2.5|
      Hemorrhage, Multifocal               |                                                                          |      1  4.0|
      Hydrocephalus                        |                                  3                                       |      3  3.0|
      Thalamus, Gliosis, Focal             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3|            |
                                           | 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  M  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +     M  +  +  +  +  +|  37        |
      Inflammation, Chronic Active, Focal  |                                           3                       2      |      7  2.4|
      Inflammation, Focal, Suppurative     |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema, Focal                         |                                                                4         |      1  4.0|
      Hemorrhage, Multifocal, Subacute     |                                                                          |      1  3.0|
      Bronchus, Epithelium, Hyperplasia,   |                                                                          |            |
           Focal                           |                                                                3         |      1  3.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |    4                                                                    4|      2  4.0|
      Vein, Mineralization, Multifocal     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lumen, Exudate                       |                                                                          |      2  1.5|
      Lumen, Foreign Body                  |          1                                                               |      2  1.5|
      Mucosa, Inflammation, Chronic        |                               1                                          |      4  1.3|
      Mucosa, Inflammation, Chronic Active |                                                                          |      2  2.0|
      Mucosa, Thrombosis, Multifocal       |                               1                    2                     |      5  2.4|
      Nasolacrimal Duct, Exudate           |          2                                                               |      1  2.0|
      Nasolacrimal Duct, Hyperplasia       |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                   2        2              2  2  2                    1   |     14  1.9|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |    2     3                          2  2                          3      |      5  2.4|
      Olfactory Epithelium, Atrophy        |                   1                 1                                    |      2  1.0|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Eosinophil                      |                                                                          |      1  2.0|
      Respiratory Epithelium, Cyst         |                   2           1                                          |      2  1.5|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Eosinophil                      | 2                                                              1         |      4  1.5|
      Respiratory Epithelium, Hyperplasia  |                            1                       1        1            |      8  1.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3|            |
                                           | 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Choroid, Left, Hemorrhage            |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Nephropathy, Chronic                 | 1  3  3  3  4  4  1  3  2  4  2  4  2     4  3  4  3  3     4  2  3  3  3|     46  3.1|
      Pigmentation, Diffuse                |       2              4        2     1                 2        3     1   |      8  2.3|
      Pigmentation, Multifocal             |                                                    3                     |      2  2.5|
      Cortex, Cyst                         |                                                                          |      1  2.0|
      Cortex, Hyperplasia, Atypical        |                                           2                              |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                 3                        |      2  3.0|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization                   |                                                 1                        |      4  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Calculus Gross Observation           |                                                                          |      1     |
      Inflammation, Chronic Active, Focal  |                                                                          |      1  2.0|
      Lumen, Calculus Micro Observation    |                                                                          |            |
          Only, Single                     |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|             
                                           | 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mineralization, Multifocal           |                                                                         4|             
      Parasite Metazoan                    |    X                 X                                               X   |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  M  +  +  +  M  +  +  +  +  +|             
      Parasite Metazoan                    |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +|             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                             2            |             
      Angiectasis, Multifocal              |                2                                                     2  2|             
      Basophilic Focus                     |                X                                               X        X|             
      Basophilic Focus, Multiple           |                      X                                                   |             
      Cytoplasmic Alteration, Focal        |                2                                                         |             
      Degeneration, Ballooning, Focal      |                                                    3           2         |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Multifocal             |                1                                      1              2   |             
      Granuloma, Multifocal                |                                           3                              |             
      Hemorrhage, Multifocal               |          2                                                               |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Focal, Nodular          |                                                                          |             
      Necrosis, Focal                      |                               1                                          |             
      Necrosis, Multifocal                 |       2           3        1                                2            |             
      Bile Duct, Fibrosis, Multifocal      |       3                                                                  |             
      Bile Duct, Hyperplasia, Multifocal   |    1  3  3  3     4  2     2  2     2  3        2  2        1  2  1  1  3|             
      Centrilobular, Degeneration, Diffuse |                                                                          |             
      Centrilobular, Degeneration,         |                                                                          |             
          Multifocal                       |                   3                                                      |             
      Centrilobular, Fatty Change, Diffuse |       3                                      3                           |             
      Periportal, Cytomegaly, Diffuse      |                                                                          |             
      Periportal, Fatty Change, Diffuse    |                         4                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +  +                                   +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|             
                                           | 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Accessory Spleen, Two                |                                  X                                       |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Artery, Inflammation, Chronic, Focal |                                                                          |             
      Artery, Mineralization, Multifocal   |                                                                         4|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |                               1        2                                 |             
      Acinus, Atrophy, Multifocal          |       1  2        3  2  1  3     2              1  2           2         |             
      Acinus, Hyperplasia, Focal           |    3                                                                     |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Focal                           |             2                                                            |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                      4                                                   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                 +                        |             
      Palate, Inflammation, Chronic, Focal |                                                 2                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          3     4        3                                                |             
      Mineralization, Diffuse              |                                                                         4|             
      Ulcer                                |                   3                                                      |             
      Epithelium, Hyperplasia              |          2     3        3                                                |             
      Submucosa, Edema, Diffuse            |                                  3                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active, Focal  |                                                                          |             
      Mineralization, Diffuse              |                                                                         4|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  3  3  2  2     3  2  2  2  2     2  2  1  3  3  3  1  2     3  4  3|             
      Mineralization, Multifocal           |                                                                         4|             
      Atrium Left, Thrombosis              |                                                                          |             
      Myocardium, Fibrosis, Focal          |                                                                3         |             
      Valve, Fibrosis, Focal               |                                                                   3      |             
      Valve, Inflammation, Focal,          |                                                                          |             
          Proliferative                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                                          X               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|             
                                           | 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Degeneration, Diffuse, Fatty         |          2        2     3        2                                       |             
      Degeneration, Fatty, Focal           |                2           2                          2  2               |             
      Degeneration, Fatty, Multifocal      |    2  2                                                                  |             
      Hyperplasia, Focal                   |                            1              1                 1     1      |             
      Hyperplasia, Multifocal              |                      1                 2                                 |             
      Hypertrophy, Focal                   |                                                                          |             
      Hypertrophy, Multifocal              |       2                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                  3                                   2   |             
      Hyperplasia, Multifocal              |          2                                                              2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                             1            |             
      Hyperplasia, Multifocal              |                3                                                         |             
      Inflammation, Multifocal             |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |          3                    2                                      2  4|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                   3                                         2            |             
      Pars Distalis, Cyst                  |             X                                                     3      |             
      Pars Distalis, Degeneration, Fatty,  |                                                                          |             
           Focal                           |                                                                   2      |             
      Pars Distalis, Hyperplasia, Focal    | 3              2  3  2                                      2            |             
      Pars Distalis, Hyperplasia           |                                                                         3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      C-Cell, Hyperplasia, Multifocal      |                                                                         2|             
      Follicle, Cyst                       |                3                                                         |             
      Follicular Cell, Degeneration,       |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                              +                           |             
      Necrosis, Focal                      |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation, Multifocal               |                                                                          |             
      Granuloma Sperm, Single              |                   3                                                      |             
      Left, Atrophy                        |                               2                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                   4                                      3               |             
      Inflammation, Chronic Active         |    2                                               3              3      |             
      Inflammation, Diffuse, Granulomatous |                                           3                              |             
      Inflammation, Focal, Granulomatous   |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|             
                                           | 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |       2                 3  2  1  3  2                                2   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                  2                             3         |             
      Hyperplasia, Multifocal              |       1              2                                                   |             
      Inflammation, Chronic Active         |       3  2     3           3        2     3  2                          2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  M  +  +  +  +  +  +     +  +  M  M  +  +  +  M  +  +  +  +  +|             
      Atrophy, Diffuse                     |                                                                3         |             
      Fibrosis, Multifocal                 |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Diffuse, Suppurative             |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           |                                        2                                 |             
      Arteriole, Inflammation              |    3           2        3                       2                        |             
      Capsule, Hyperplasia, Multifocal     |                                                                          |             
      Interstitial Cell, Hyperplasia       |                2                                                         |             
      Seminiferous Tubule, Atrophy         |                   2  4     2                                   3         |             
      Seminiferous Tubule, Degeneration    |       3                 2                    2        3                  |             
      Serosa, Necrosis, Focal              |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        2                             3   |             
      Myeloid Cell, Hyperplasia            |          2                                               3               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Hemorrhage                   |                                                                          |             
      Mediastinal, Hemorrhage              |                         3                       3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       3                  |             
      Hyperplasia, Lymphoid                |                                                          2               |             
      Hyperplasia, Plasma Cell             |                         2                 3                          2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                         3|             
      Fibrosis, Multifocal                 |       2                                                                  |             
      Hemorrhage                           |                         2  2                                             |             
      Hyperplasia, Lymphoid                |                                                          2               |             
      Hyperplasia, Re Cell                 |          2                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis, Focal                      |       3                                                        2         |             
      Pigmentation, Hemosiderin            |                         2                 3           2                  |             
      Thrombosis, Single                   |                            3                                             |             
      Capsule, Fibrosis, Focal             |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|             
                                           | 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Capsule, Fibrosis, Multifocal        |                                  3                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  M  +  +  +  +  M  +|             
      Depletion Lymphoid                   |                                                                         4|             
      Hyperplasia, Tubular                 |                2                                               3         |             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia, Diffuse                     |                         4                                                |             
      Ectasia, Multifocal                  |    4  2                    4              3           4                  |             
      Granuloma                            |                                                                      2   |             
      Hyperplasia, Diffuse                 |                                                    2        2        3  2|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                      3   |             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Cyst            |             X                                                            |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                2                                                        3|             
      Osteopetrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                         X  X              X     X     X              X   |             
      Hemorrhage, Focal                    |                                                                          |             
      Hemorrhage, Multifocal               |                                                                          |             
      Hydrocephalus                        |                         2  2                    1     2                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  M  +  +  +  M  +  +  +  +  +|             
      Inflammation, Chronic, Multifocal    |                            2                                             |             
      Inflammation, Chronic Active, Focal  |          2                    2                                      1   |             
      Submucosa, Dilatation                |                                                                         3|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Multifocal, Subacute     |                                                                          |             
      Mineralization, Multifocal           |                                                                         4|             
      Artery, Mineralization, Focal        |                                              2                           |             
      Bronchus, Hyperplasia, Focal,        |                                                                          |             
          Lymphoid                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|             
                                           | 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Interstitium, Inflammation, Acute,   |                                                                          |             
           Multifocal                      |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                         3|             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                        3                             3   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                               3                                          |             
      Lumen, Foreign Body                  |                            2                          1                  |             
      Mucosa, Inflammation, Chronic        |                               2     1                                    |             
      Mucosa, Inflammation, Chronic Active |    2     1     1                                      2                  |             
      Mucosa, Thrombosis, Multifocal       |                                     4        2                           |             
      Nasolacrimal Duct, Exudate           |                                                                          |             
      Nasolacrimal Duct, Fungus            |                                                       4                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                            2                 1        4     1     1     1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                      2                                                   |             
      Olfactory Epithelium, Atrophy        |          2                                                              1|             
      Olfactory Epithelium, Cyst           |                                  1                                1      |             
      Olfactory Epithelium, Erosion        |                                                                          |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic Active                  |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                 1     1                  |             
      Respiratory Epithelium, Cyst         | 1  2  2  1                                                               |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Eosinophil                      |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |    3  1  2     3  1     1  2  2  2  1  2        2  1  1  1  1     2  2  2|             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Papillary                       |                               2                       1                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                     2                                    |             
      Glands, Metaplasia, Focal, Squamous  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                 +     +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Mineralization, Diffuse              |                                                                         4|             
      Nephropathy, Chronic                 | 4  4  4  4     4  3  4  4  4  4  4  1  4  4  2  4  4  4  3  4  4  4  4  4|             
      Pigmentation, Diffuse                |                                                                          |             
      Pigmentation, Multifocal             |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|             
                                           | 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Focal                           |                                                                          |             
      Cortex, Cyst                         |                                                                      X   |             
      Cortex, Hyperplasia, Atypical        |       2        2                                                         |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis, Acute, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Ectasia                              |                                                                          |             
      Inflammation, Diffuse, Subacute      |                                                                          |             
      Subserosa, Mineralization, Focal     |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3|            |
                                           | 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                                                    2                     |      1  2.0|
      Parasite Metazoan                    |       X              X                       X                          X|      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                    2                     |      1  2.0|
      Mineralization, Multifocal           |                                                                          |      1  4.0|
      Parasite Metazoan                    |                      X  X                                               X|      6     |
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  M  +  +  +  +  +|  40        |
      Parasite Metazoan                    |                            X                                             |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  44        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                3                                                         |      2  2.5|
      Angiectasis, Multifocal              |                                                                          |      3  2.0|
      Basophilic Focus                     |                                                                          |      3     |
      Basophilic Focus, Multiple           |                                                                          |      1     |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Degeneration, Ballooning, Focal      |                         2                                                |      3  2.3|
      Eosinophilic Focus                   |                                              X                           |      1     |
      Fatty Change, Diffuse                |          4                                                               |      1  4.0|
      Fatty Change, Multifocal             |             1        1        2                       1              1   |      8  1.3|
      Granuloma, Multifocal                |             2           2     3                                          |      4  2.5|
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                        X     X                 X         |      3     |
      Hyperplasia, Focal, Nodular          |                                                                   3      |      1  3.0|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Necrosis, Multifocal                 |    2  3           2                                                  3   |      8  2.3|
      Bile Duct, Fibrosis, Multifocal      |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia, Multifocal   |    2  3                 2  2           2  3  1  3  2        4  1  3     3|     30  2.3|
      Centrilobular, Degeneration, Diffuse |                                                 2                        |      1  2.0|
      Centrilobular, Degeneration,         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3|            |
                                           | 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
          Multifocal                       |                   2                                         2     3      |      4  2.5|
      Centrilobular, Fatty Change, Diffuse |    4  3                                                                  |      4  3.3|
      Periportal, Cytomegaly, Diffuse      |                      1                                                   |      1  1.0|
      Periportal, Fatty Change, Diffuse    |                4                                                         |      2  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +                                               +                  |   6        |
      Accessory Spleen, Two                |                                                                          |      1     |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       | 2                                                                        |      1  2.0|
      Artery, Inflammation, Chronic, Focal |       2                                                                  |      1  2.0|
      Artery, Mineralization, Multifocal   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy, Focal               |                                                                          |      2  1.5|
      Acinus, Atrophy, Multifocal          |    2              1  2              2  4     2     3        1  2  2      |     20  2.0|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |                                  3                                       |      2  2.5|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Inflammation, Chronic, Focal |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |          3                                            3                  |      5  3.2|
      Mineralization, Diffuse              |                                                                          |      1  4.0|
      Ulcer                                |                4                                                     4   |      3  3.7|
      Epithelium, Hyperplasia              |          3     2                                      2                  |      6  2.5|
      Submucosa, Edema, Diffuse            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active, Focal  |                                                                   3      |      1  3.0|
      Mineralization, Diffuse              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 4     2  2  1  2     2  3  2  1  3  3     2  2     2  2  3  1     2  3   |     40  2.3|
      Mineralization, Multifocal           |                                                                          |      1  4.0|
      Atrium Left, Thrombosis              |       3                                                           4      |      2  3.5|
      Myocardium, Fibrosis, Focal          |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3|            |
                                           | 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Valve, Fibrosis, Focal               |                                                                          |      1  3.0|
      Valve, Inflammation, Focal,          |                                                                          |            |
          Proliferative                    |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                         X                 X                       X      |      4     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Degeneration, Diffuse, Fatty         | 2  2  2        2  1                                                      |      9  2.0|
      Degeneration, Fatty, Focal           |          2                    2                                          |      6  2.0|
      Degeneration, Fatty, Multifocal      |                            2                                             |      3  2.0|
      Hyperplasia, Focal                   |          1                 2  1  2        2                    2         |     10  1.4|
      Hyperplasia, Multifocal              |                                                                          |      2  1.5|
      Hypertrophy, Focal                   |    1                                                                     |      1  1.0|
      Hypertrophy, Multifocal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  46        |
      Hyperplasia, Focal                   |                            1     2                                1      |      5  1.8|
      Hyperplasia, Multifocal              |                   2                          1                           |      4  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                          3               |      2  2.0|
      Hyperplasia, Multifocal              |    2                    2                 4  4                           |      5  3.0|
      Inflammation, Multifocal             |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |             1                                                            |      5  2.4|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                 3                        |      3  2.7|
      Pars Distalis, Cyst                  |    4              2                                   3                  |      5  3.0|
      Pars Distalis, Degeneration, Fatty,  |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |             3                 3                                          |      7  2.6|
      Pars Distalis, Hyperplasia           |                                                             3            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |                                        2                    1            |      2  1.5|
      C-Cell, Hyperplasia, Multifocal      |             3           1                                                |      3  2.0|
      Follicle, Cyst                       |             3                                                            |      2  3.0|
      Follicular Cell, Degeneration,       |                                                                          |            |
          Multifocal                       |                         2                                                |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3|            |
                                           | 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Necrosis, Focal                      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation, Multifocal               |                      3                                                   |      1  3.0|
      Granuloma Sperm, Single              |                                                                          |      1  3.0|
      Left, Atrophy                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Ectasia                              |                                  3                                       |      3  3.3|
      Inflammation, Chronic Active         |                                                                2         |      4  2.5|
      Inflammation, Diffuse, Granulomatous |                                                                          |      1  3.0|
      Inflammation, Focal, Granulomatous   |                               2                                         2|      3  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |    2  3  2  1  2     3     2     2  2  1  1     3  2     2  2            |     22  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                            2        2  3                                 |      5  2.4|
      Hyperplasia, Multifocal              |                   2  2  3                    1                           |      6  1.8|
      Inflammation, Chronic Active         |                4              3        1  1        2                     |     13  2.4|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|  43        |
      Atrophy, Diffuse                     |             2                          3  3        2                     |      5  2.6|
      Fibrosis, Multifocal                 |                         2                                                |      1  2.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Diffuse, Suppurative             |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization, Multifocal           |                                                                          |      1  2.0|
      Arteriole, Inflammation              |                                                                          |      4  2.5|
      Capsule, Hyperplasia, Multifocal     |                                                                   2      |      1  2.0|
      Interstitial Cell, Hyperplasia       |                      2                                                   |      2  2.0|
      Seminiferous Tubule, Atrophy         |          2  3  3              3  2        4        3  3        3         |     13  2.8|
      Seminiferous Tubule, Degeneration    |                                                                          |      4  2.5|
      Serosa, Necrosis, Focal              |                                                                   3      |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                       3     3           2|      5  2.6|
      Myeloid Cell, Hyperplasia            |                                              4           3               |      4  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3|            |
                                           | 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumbar, Hemorrhage                   |                                              3                           |      1  3.0|
      Mediastinal, Hemorrhage              |             3     2                             2                        |      5  2.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                    4     2               |      3  2.7|
      Hyperplasia, Plasma Cell             |                                                          2           3   |      5  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Fibrosis, Multifocal                 |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                                                          3               |      2  2.5|
      Hyperplasia, Re Cell                 |                                                    2                 3   |      3  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                                                         3|      1  3.0|
      Depletion Lymphoid                   |                                                                         3|      1  3.0|
      Fibrosis, Focal                      |                                                             2  3         |      4  2.5|
      Pigmentation, Hemosiderin            |          3                    3                                2     2   |      7  2.4|
      Thrombosis, Single                   |                                                                          |      1  3.0|
      Capsule, Fibrosis, Focal             |                                                                          |      1  4.0|
      Capsule, Fibrosis, Multifocal        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | A  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  +  M  +|  38        |
      Depletion Lymphoid                   |                                                                          |      1  4.0|
      Hyperplasia, Tubular                 |                   2     3        3                          2            |      6  2.5|
      Artery, Inflammation, Chronic Active |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
      Ectasia, Diffuse                     |          3           4                                               4   |      4  3.8|
      Ectasia, Multifocal                  |                3                                                         |      6  3.3|
      Granuloma                            |                                                                          |      1  2.0|
      Hyperplasia, Diffuse                 |                                     2     2        1                     |      7  2.0|
      Hyperplasia, Focal                   |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Focal         |                                                                          |      1  3.0|
      Ulcer                                |                                                    4                     |      1  4.0|
      Subcutaneous Tissue, Cyst            |                                                                          |      1     |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                    4                     |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3|            |
                                           | 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      2  2.5|
      Osteopetrosis                        |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                      X                             3                 X   |      9  3.0|
      Hemorrhage, Focal                    |                                     3                                    |      1  3.0|
      Hemorrhage, Multifocal               |                   4                                         2            |      2  3.0|
      Hydrocephalus                        |          2           2              2                                2   |      8  1.9|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +     M  +  +  +  +  +|  41        |
      Inflammation, Chronic, Multifocal    |                                              1                           |      2  1.5|
      Inflammation, Chronic Active, Focal  |                            2                                            2|      5  1.8|
      Submucosa, Dilatation                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Multifocal, Subacute     |                   2                                                      |      1  2.0|
      Mineralization, Multifocal           |                                                                          |      1  4.0|
      Artery, Mineralization, Focal        |                                                                          |      1  2.0|
      Bronchus, Hyperplasia, Focal,        |                                                                          |            |
          Lymphoid                         |                                                    2                     |      1  2.0|
      Interstitium, Inflammation, Acute,   |                                                                          |            |
           Multifocal                      |                                                                         2|      1  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      | 1                                                                        |      2  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active, Multifocal               |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Exudate                       |                2                                                         |      2  2.5|
      Lumen, Foreign Body                  |                1  1                                                      |      4  1.3|
      Mucosa, Inflammation, Chronic        |                2              1                       2                 1|      6  1.5|
      Mucosa, Inflammation, Chronic Active |                                                                          |      4  1.5|
      Mucosa, Thrombosis, Multifocal       |       3                                                                  |      3  3.0|
      Nasolacrimal Duct, Exudate           | 3                                   1                             2      |      3  2.0|
      Nasolacrimal Duct, Fungus            |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3|            |
                                           | 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                               2     1     3  1                           |     10  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  | 3           1                                         2           3      |      5  2.2|
      Olfactory Epithelium, Atrophy        |                                                                      2   |      3  1.7|
      Olfactory Epithelium, Cyst           |                            1     1        1  1                           |      6  1.0|
      Olfactory Epithelium, Erosion        |          2                                                               |      1  2.0|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Chronic Active                  |          1                                                               |      1  1.0|
      Olfactory Epithelium, Metaplasia     |          2                          2                                    |      4  1.5|
      Respiratory Epithelium, Cyst         |       1  2                 1              1                             1|      9  1.3|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Eosinophil                      |                                           1                              |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |                2  2                 1  1     2  2              1  1      |     27  1.6|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Papillary                       |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                          1               |      2  1.5|
      Glands, Metaplasia, Focal, Squamous  |                                           2                              |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                +                     |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Focal, Suppurative     |                1                                                         |      1  1.0|
      Mineralization, Diffuse              |                                                                          |      1  4.0|
      Nephropathy, Chronic                 | 2  1  3  1  4  4  3  4  4  4  2  4  4  4  4  4  2  4     1  3  4  3  4  4|     48  3.5|
      Pigmentation, Diffuse                |    1  2                                         3           1     3      |      5  2.0|
      Pigmentation, Multifocal             |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |                                                    3                     |      1  3.0|
      Cortex, Cyst                         |          X                                                              3|      3  3.0|
      Cortex, Hyperplasia, Atypical        |                                                                          |      2  2.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Necrosis, Acute, Multifocal     |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                                                             4            |      1  4.0|
      Inflammation, Diffuse, Subacute      |                                                                      3   |      1  3.0|
      Subserosa, Mineralization, Focal     |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|             
                             DAY ON TEST   | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|             
                                           | 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +           +  +     +        +        +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +           +  +     +        +        +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          M           +  M     +        +        A     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +           +  +     +        +        A     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +           +  +     M        +        A     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +           +  +     +        +        +     +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +           +  +     +        +        A     +     +  +  +     +|             
      Inflammation, Acute, Multifocal      |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +           +  +     +        +        A     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +           +  +     +        +        A     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                            2                          2                  |             
      Basophilic Focus                     |                            X           X                          X      |             
      Basophilic Focus, Multiple           |                                                       X                  |             
      Congestion                           |                                     4           3                        |             
      Cytomegaly, Focal                    |                                                                          |             
      Cytomegaly, Multifocal               |                                                                          |             
      Eosinophilic Focus                   |                                                                X         |             
      Fatty Change, Diffuse                |                                                             4        3  2|             
      Fatty Change, Focal                  |                               3                                          |             
      Fatty Change, Multifocal             |                                                       1  2               |             
      Hepatodiaphragmatic Nodule           |                         X                                                |             
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |             
      Mitotic Alteration                   |                                     1                                    |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                                                   2      |             
      Pigmentation, Multifocal             |                         2                                                |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |    2     3              2              2  2  3        1  3     1  2      |             
      Centrilobular, Degeneration, Diffuse |       3                                      2                           |             
      Centrilobular, Fatty Change, Diffuse |                         3                                                |             
      Centrilobular, Necrosis, Multifocal  |                                                                          |             
      Periportal, Fatty Change, Diffuse    |             2                                                            |             
      Portal, Fibrosis, Multifocal         |                                        2                                 |             
      Portal, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                      1                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
      Artery, Ectasia, Multifocal          |                                                                          |             
      Artery, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Artery, Mineralization, Multifocal   |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +           +  M     +              +  +     +     +  +  +      |             
      Acinus, Atrophy, Diffuse             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|             
                             DAY ON TEST   | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|             
                                           | 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinus, Atrophy, Multifocal          |                                              2                           |             
      Artery, Ectasia, Multifocal          |                                                                          |             
      Artery, Fibrosis                     |                                                                          |             
      Artery, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Artery, Mineralization, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +           +  +     +  +     +        +     +     +     +      |             
                                            __________________________________________________________________________|             
   Stomach                                 |          +           +  +     +        +        +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +           +  +     +        +        +     +     +  +  +      |             
      Inflammation, Chronic Active         |                               3                             4            |             
      Ulcer                                |                                                             4            |             
      Epithelium, Hyperplasia              |                               2                             2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +           +  +     +        +        +     +     +  +  +      |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                +                       +                                 |             
      Dysplasia                            |                3                       1                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +           +  +     +        +        +     +     +  +  +      |             
      Cardiomyopathy                       |          1                             3        4     2     2  3  2      |             
      Atrium Left, Thrombosis              |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +     +     +  +     +        +        +     +  +  +  +  +     +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                               X                       X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +           +  +     +        +        +     +  +  +  +  +     +|             
      Degeneration, Diffuse, Fatty         |                         3                                   2     2      |             
      Degeneration, Fatty, Focal           |                                        2              2     3            |             
      Degeneration, Fatty, Multifocal      |                                                                          |             
      Hyperplasia, Focal                   |                               3                                          |             
      Hypertrophy, Focal                   |                                                       2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +     +     +  +     +        +        +        +  +  +  +     M|             
      Hyperplasia, Focal                   |                                        2                          3      |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +           +  M     +              +  +     +     +  +  +      |             
      Hyperplasia, Multifocal              |                      2                                1                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          +           +  +     +        +        +     +     M  +  +      |             
      Hyperplasia                          |                                        3                                 |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +     +  +  +  +        +     +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|             
                             DAY ON TEST   | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|             
                                           | 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  |                   2              3                                       |             
      Pars Distalis, Hyperplasia, Focal    |                         3                                                |             
      Pars Distalis, Hyperplasia           |                                                                3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |          +        +  +  +     +        +        +     +     M  +  +      |             
      C-Cell, Hyperplasia, Focal           |                                                                   2      |             
      C-Cell, Hyperplasia, Multifocal      |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |          +           +  +     +        +        +     +     +  +  M      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +           +  +     +        +        +     +     +  +  +     +|             
      Abscess                              |                                                                4         |             
      Ectasia                              |          3                                                              4|             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                      2                 1              2                  |             
                                            __________________________________________________________________________|             
   Prostate                                |          +     +     +  +     +        +  +     +           +  +  +      |             
      Hyperplasia, Multifocal              |                3                       4                                 |             
      Inflammation, Chronic Active         |                      1  2                                   3     2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +     M           +  M     M        +  +     M     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +|             
      Hemorrhage                           |                                                                          |             
      Mineralization, Multifocal           |                                                                          |             
      Arteriole, Inflammation              |                                                       3                  |             
      Interstitial Cell, Hyperplasia       |                3                                                        2|             
      Seminiferous Tubule, Atrophy         | 3              4                       3     2                          3|             
      Serosa, Necrosis, Focal              |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +           +  +     +        +        +     +     +  +  +      |             
      Atrophy                              |                                                       3                  |             
      Hyperplasia                          |                                                                2         |             
      Metaplasia, Osseous                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +        +  +  +  +  +     +  +     +  +     +     +  +  +      |             
      Mediastinal, Hemorrhage              |                                        2                                 |             
      Pancreatic, Hemorrhage               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +  +           +  M  +  +        +        +     +     +     +      |             
      Hemorrhage                           |       3                                                                  |             
      Hyperplasia, Plasma Cell             |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       M  +        +  +  +     +                 +     +     +  +  +      |             
      Hemorrhage                           |                   3                                               2      |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Congestion                           |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|             
                             DAY ON TEST   | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|             
                                           | 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis, Focal                      |                                                          2               |             
      Fibrosis, Multifocal                 |                                  3                                       |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Pigmentation, Hemosiderin            |                                                             2            |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +        +  +  +     M        +        M     +     +  +  +      |             
      Angiectasis, Multifocal              |                                                                          |             
      Hemorrhage                           |       3                                                                  |             
      Hyperplasia, Tubular                 |                                        2                       2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +        +  M     +        +        +     +     +  +  +  +   |             
      Ectasia, Diffuse                     | 4                             2                                      3   |             
      Ectasia, Multifocal                  |             4        3                 1              2     3     2      |             
      Hyperplasia, Diffuse                 |    2                                                                     |             
      Inflammation, Granulomatous          | 3                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +  +     +  +  +  +        +     +  +     +     +  +  +      |             
      Cyst Epithelial Inclusion            |    X                       4                                             |             
      Hyperkeratosis                       |                4                                               3         |             
      Hyperplasia, Squamous                |                2                                                         |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |    4           4                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +        +  +  +     +        +        +     +     +  +  +      |             
      Fibrous Osteodystrophy               |                   3                                                      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemorrhage, Acute                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +           +  +     +        +        +     +     +  +  +      |             
      Compression                          |                      X        X                 X     X     X            |             
      Hydrocephalus                        |                               2                       3                  |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Multifocal, Mixed Cell          |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |          M           M  M     M        +        M     +     +  +  M      |             
      Inflammation, Chronic Active, Focal  |                                                                2         |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                             3        3   |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|             
                             DAY ON TEST   | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|             
                                           | 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Diffuse                         |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |             2     3                                               1      |             
      Interstitium, Mineralization,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |             1                                                            |             
      Lumen, Foreign Body                  |                   3                                   1                  |             
      Mucosa, Inflammation, Chronic        | 2                    3           1                                       |             
      Mucosa, Inflammation, Chronic Active |                   3                                            1     2   |             
      Mucosa, Thrombosis, Multifocal       |       2                 3                                                |             
      Nasolacrimal Duct, Exudate           |       4                                                                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |       2                                                                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |          2  1        2     2        1                    1        2      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Cyst           |                1                                                         |             
      Olfactory Epithelium, Erosion        |                                                    3     1  1        2  1|             
      Olfactory Epithelium, Metaplasia     |                2  1                                                  1   |             
      Respiratory Epithelium, Cyst         |       2     1              2        2                    2        1      |             
      Respiratory Epithelium, Hyperplasia  | 1           1     3        1     2     2  2  2     2           1     1  2|             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Papillary                       |                   3  2                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 |          +           +  +     +        +        +     +     M  +  +      |             
      Inflammation, Chronic                |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Anterior, Synechia                   |                                              4                           |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Lens, Right, Cataract                |                                              4                           |             
      Retina, Degeneration                 |                                              4                           |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +  +  +  +  +     +     +  +     +  +     +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                        2                                 |             
      Inflammation, Acute, Multifocal,     |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|             
                             DAY ON TEST   | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|             
                                           | 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy, Chronic                 |          2  4  4  4  3        2     2  4     2  2     4  3  4  4  4  4  4|             
      Pigmentation, Diffuse                |                                     3                                    |             
      Pigmentation, Multifocal             |                                                                          |             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +           +  +     +        +        +           +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3|            |
                                           | 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +     +              +        +           +                     |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +     +              +        +           +                     |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          M     +              A        M           +                     |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +     +              A        +           +                     |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +     +              A        +           +                     |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +     +              +        +           +                     |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +     +              A        +           +                     |  14        |
      Inflammation, Acute, Multifocal      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +     M              A        +           +                     |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +     +              A        +           +                     |  13        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|  42        |
      Angiectasis, Focal                   |                         3                                                |      3  2.3|
      Basophilic Focus                     |                                                       X                  |      4     |
      Basophilic Focus, Multiple           |                         X                                X               |      3     |
      Congestion                           |                                                                          |      2  3.5|
      Cytomegaly, Focal                    |                                     2                                    |      1  2.0|
      Cytomegaly, Multifocal               |                                                    2                     |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      1     |
      Fatty Change, Diffuse                |                                                                          |      3  3.0|
      Fatty Change, Focal                  |                                                                          |      1  3.0|
      Fatty Change, Multifocal             |    3                                                                     |      3  2.0|
      Hepatodiaphragmatic Nodule           |    X                                                                    X|      3     |
      Hepatodiaphragmatic Nodule, Multiple |                                  X                                       |      1     |
      Mitotic Alteration                   |                                                    2                     |      2  1.5|
      Necrosis, Focal                      |                                        2                                 |      1  2.0|
      Necrosis, Multifocal                 |          1                 2                                             |      3  1.7|
      Pigmentation, Multifocal             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Multifocal|                      2                                                   |      1  2.0|
      Bile Duct, Hyperplasia, Multifocal   | 3              1  2  1  2  2                 2     2  1  2  3  3        2|     23  2.0|
      Centrilobular, Degeneration, Diffuse |          2        2                          2                           |      5  2.2|
      Centrilobular, Fatty Change, Diffuse |                                        4                                 |      2  3.5|
      Centrilobular, Necrosis, Multifocal  |                                                                   3      |      1  3.0|
      Periportal, Fatty Change, Diffuse    |                                                                          |      1  2.0|
      Portal, Fibrosis, Multifocal         |                                                                          |      1  2.0|
      Portal, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                    +        +               |   4        |
      Artery, Ectasia, Multifocal          |                                                 4                        |      1  4.0|
      Artery, Inflammation, Chronic,       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3|            |
                                           | 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
          Multifocal                       |                                                 4                        |      1  4.0|
      Artery, Mineralization, Multifocal   |                                                 4                        |      1  4.0|
      Fat, Necrosis, Focal                 |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +     +     +        A  +     +        +  +           +         |  19        |
      Acinus, Atrophy, Diffuse             |                                                 4                        |      1  4.0|
      Acinus, Atrophy, Multifocal          |                                                                3         |      2  2.5|
      Artery, Ectasia, Multifocal          |                                                 4                        |      1  4.0|
      Artery, Fibrosis                     |    3                                                                     |      1  3.0|
      Artery, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                                 4                        |      1  4.0|
      Artery, Mineralization, Multifocal   |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                      +   |   1        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +     +           +  +        +        +  +                     |  18        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +     +              +        +           +                     |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +     +              A        +           M                     |  13        |
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
      Ulcer                                |                                                                          |      1  4.0|
      Epithelium, Hyperplasia              |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +     +              A        +           +                     |  14        |
      Infiltration Cellular, Lymphocyte    |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                 +                        |   3        |
      Dysplasia                            |                                                 1                        |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +     +              M        +           +                     |  14        |
      Cardiomyopathy                       |          1     1                                   2                     |     10  2.1|
      Atrium Left, Thrombosis              |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +     +  +  +           +  +  +     +           +  +              +   |  24        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +  +  +           +  A        +           +  +              +   |  20        |
      Degeneration, Diffuse, Fatty         |                            1           3                                 |      5  2.2|
      Degeneration, Fatty, Focal           |                                                    1                     |      4  2.0|
      Degeneration, Fatty, Multifocal      |             2                                                            |      1  2.0|
      Hyperplasia, Focal                   |                                                       2                  |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3|            |
                                           | 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hypertrophy, Focal                   |          2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +     +  +  +           +  A  +     +           +  +              +   |  21        |
      Hyperplasia, Focal                   |                                                    2                     |      3  2.3|
      Hyperplasia, Multifocal              |                                        2                             2   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +     +              A  +     +        +  +           +         |  16        |
      Hyperplasia, Multifocal              |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +     +              +        +           +                     |  14        |
      Hyperplasia                          |                                        2                                 |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +     +           +  A  +  +  +  +  +  +  +     +     +     +   |  35        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  | 2                                                  1                     |      4  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                     2              2                     |      3  2.3|
      Pars Distalis, Hyperplasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +     +     +           +  +        +           +  +        +     +   |  20        |
      C-Cell, Hyperplasia, Focal           |                                                                          |      1  2.0|
      C-Cell, Hyperplasia, Multifocal      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +     +              +        +        +  +              +      |  16        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +  +  +        +     +        +           +                     |  18        |
      Abscess                              |                         4                                                |      2  4.0|
      Ectasia                              |                                                                          |      2  3.5|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |          2                                                               |      4  1.8|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +     M     +              +     +  +  +        +                     |  18        |
      Hyperplasia, Multifocal              |                                                                          |      2  3.5|
      Inflammation, Chronic Active         |                                     2              2                     |      6  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +     M     +              M     +     +        M                 +   |  13        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +  +  +        +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|  42        |
      Hemorrhage                           |                         4                                                |      1  4.0|
      Mineralization, Multifocal           |                                                             2            |      1  2.0|
      Arteriole, Inflammation              |                                                 2                        |      2  2.5|
      Interstitial Cell, Hyperplasia       |                                        2           2                     |      4  2.3|
      Seminiferous Tubule, Atrophy         |                         3           3  2  2     2           3            |     11  2.7|
      Serosa, Necrosis, Focal              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3|            |
                                           | 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +     +        +     A        +           +                     |  15        |
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia                          |                         2                                                |      2  2.0|
      Metaplasia, Osseous                  |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +     +     +  +  +  +        +     +  +  +                     |  27        |
      Mediastinal, Hemorrhage              |    4                                                                     |      2  3.0|
      Pancreatic, Hemorrhage               |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +        M     M           +  A        M        +  +                     |  14        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +        M     +        +  +  A        +     +     +                     |  17        |
      Hemorrhage                           |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +     +  +  +  +  +  +     +  +  +  +     +  +  +  +  +         |  35        |
      Congestion                           |                                                                          |      1  4.0|
      Fibrosis, Focal                      |                                                          3               |      2  2.5|
      Fibrosis, Multifocal                 |                                                             4            |      2  3.5|
      Hematopoietic Cell Proliferation     |                                           4        3                     |      2  3.5|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +     M           +  M        +           +                     |  14        |
      Angiectasis, Multifocal              |                                        2                                 |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Tubular                 |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +     M              +  +     +        +  +                 +   |  20        |
      Ectasia, Diffuse                     |                                                 3                        |      4  3.0|
      Ectasia, Multifocal                  |                                        2                                 |      7  2.4|
      Hyperplasia, Diffuse                 |                                                                      2   |      2  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +     +              +  +  +  +           +                     |  23        |
      Cyst Epithelial Inclusion            | X                                                                        |      3  4.0|
      Hyperkeratosis                       |                                                                          |      2  3.5|
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +  +              +        +        +  +                     |  18        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3|            |
                                           | 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Fibrous Osteodystrophy               |             3                                   4                        |      3  3.3|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +        +                 +                    +         |   4        |
      Hemorrhage, Acute                    |                         4                                      4         |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +     +              +        +           +                     |  15        |
      Compression                          |                                                                          |      5     |
      Hydrocephalus                        |                                                                          |      2  2.5|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Multifocal, Mixed Cell          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |          +     M              M                    M                     |   5        |
      Inflammation, Chronic Active, Focal  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                  2                                       |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                                                          |      2  3.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Diffuse                         |                                                 2                        |      1  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                           1                              |      4  1.8|
      Interstitium, Mineralization,        |                                                                          |            |
          Multifocal                       |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Exudate                       |                               2  4     3                    2            |      5  2.4|
      Lumen, Foreign Body                  |                               1              1              1            |      5  1.4|
      Mucosa, Inflammation, Chronic        |                                                 1                        |      4  1.8|
      Mucosa, Inflammation, Chronic Active |                   2              4     1     2              1  2         |      9  2.0|
      Mucosa, Thrombosis, Multifocal       |                   1        4                                      4      |      5  2.8|
      Nasolacrimal Duct, Exudate           |    3                                            1                        |      3  2.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |    1  1           1              2        1        1  1     1           1|     16  1.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                 1                        |      1  1.0|
      Olfactory Epithelium, Atrophy        |                                                 1                        |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3|            |
                                           | 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Olfactory Epithelium, Cyst           |                         1                    1        1                  |      4  1.0|
      Olfactory Epithelium, Erosion        |    1  1                                            1                     |      8  1.4|
      Olfactory Epithelium, Metaplasia     |                                        2                       1        1|      6  1.3|
      Respiratory Epithelium, Cyst         | 1     1                 1                             2     2  1  2      |     13  1.5|
      Respiratory Epithelium, Hyperplasia  |    2        1     1  2              2  1  3  1  1           1  1     1   |     24  1.5|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Papillary                       |                   2              2                          2            |      5  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +     +              +        +           +                     |  14        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                 +                        |   2        |
      Anterior, Synechia                   |                                                                          |      1  4.0|
      Cornea, Inflammation, Chronic Active |                                                 4                        |      1  4.0|
      Lens, Right, Cataract                |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +  +  +     +  +     A  +     +  +  +  +  +  +     +     +  +   |  35        |
      Bacterium                            |    4                                                                     |      1  4.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Inflammation, Acute, Multifocal,     |                                                                          |            |
           Suppurative                     |    4                                                                     |      1  4.0|
      Nephropathy, Chronic                 |    4     2  4  1     3  4        4     4  2  2  4  1  4           4  4   |     32  3.2|
      Pigmentation, Diffuse                |                                                             1            |      2  2.0|
      Pigmentation, Multifocal             |                2                                                         |      1  2.0|
      Cortex, Cyst                         |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          M     +              +        +           M                     |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
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