National Toxicology Program

National Toxicology Program
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TDMS Study 05070-01 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Midwest Research Inst                                     DATE: 09/08/94   
EXP: 05070                      VINYL TOLUENE                  TIME: 22:47:29   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 56406    
CONT: N01-ES-38042                                             CAS: 25013154    
PATHOLOGIST: M. STEDHAM                                                         
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Midwest Research Inst                                     DATE: 09/08/94  
EXP: 05070                      VINYL TOLUENE                  TIME: 22:47:29  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 56406   
CONT: N01-ES-38042                                             CAS: 25013154   
PATHOLOGIST: M. STEDHAM                                                        

                                   VINYL TOLUENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 728 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 49     UNCENSORED DEATHS 30     CENSORED DEATHS 0    TERMINAL 19        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      371   422   492   506   511   511   520   525   532   553                 |
 |      557   599   607   613   621   623   623   633   638   643                 |
 |      647   652   658   673   683   693   697   700   714   721                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 100 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 33     CENSORED DEATHS 0    TERMINAL 17        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      393   465   479   484   499   519   533   539   539   554                 |
 |      554   583   593   611   613   623   624   627   633   637                 |
 |      658   660   666   680   687   687   689   694   695   697                 |
 |      697   700   714                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 300 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 31     CENSORED DEATHS 0    TERMINAL 19        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      506   512   519   529   541   541   548   548   567   575                 |
 |      589   611   617   638   644   647   648   653   660   666                 |
 |      667   669   678   679   694   700   701   704   711   721                 |
 |      724                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                   VINYL TOLUENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 728 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   728 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0  95.9  95.9  81.6  75.5  53.1  38.8      |
 |           |                                                                    |
 |           |                                                                    |
 |100 PPM    |   100.0 100.0 100.0 100.0  98.0  92.0  82.0  74.0  56.0  34.0      |
 |           |                                                                    |
 |           |                                                                    |
 |300 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0  88.0  78.0  62.0  38.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          100 PPM          300 PPM       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       38.8%            34.0%            38.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.762N         P=0.825          P=0.878N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       597.9            606.8            626.0         |
 |NATURAL DEATHS (C)      |       (16.0)           (14.6)           (12.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       648.4            648.0            664.8         |
 |(STANDARD ERROR)        |       (13.4)           (12.6)           (10.4)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                   VINYL TOLUENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 728 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 0    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      166   434   470   545   553   582   592   613   630   630                 |
 |      635   659   679   683   688   701   708   708   718                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 100 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      421   495   499   526   548   560   583   624   624   637                 |
 |      637   659   661   675   693   696   701   703   707   707                 |
 |      709   714                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 300 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 24     CENSORED DEATHS 0    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      414   434   444   456   499   506   526   576   576   582                 |
 |      606   614   626   637   646   680   681   683   690   697                 |
 |      709   709   714   718                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                   VINYL TOLUENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 728 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   728 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0  98.0  98.0  98.0  98.0  94.0  92.0  86.0  76.0  62.0      |
 |           |                                                                    |
 |           |                                                                    |
 |100 PPM    |   100.0 100.0 100.0 100.0  98.0  98.0  92.0  86.0  74.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 |300 PPM    |   100.0 100.0 100.0 100.0  98.0  92.0  86.0  80.0  70.0  52.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          100 PPM          300 PPM       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       62.0%            56.0%            52.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.359          P=0.713          P=0.383       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       599.7            626.3            601.0         |
 |NATURAL DEATHS (C)      |       (30.3)           (18.1)           (20.2)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       679.2            683.3            667.0         |
 |(STANDARD ERROR)        |       (14.4)           (10.7)           (13.2)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                           VINYL TOLUENE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        100 PPM          = 2
                                                        300 PPM          = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                         1    2                3
      |                                                           1    2   1      2     33
      |                                                                    1      2 221 13 33
      |                                                                              2 2    3 3
   90 +                                                                                2   2
      |                                                                                 1  1 233
P     |                                                                                        3 3
E     |                                                                                    112 123 3
R  80 +                                                                                        11  3  3
C     |                                                                                         1   2 31 3
E     |                                                                                             2 21123  3
N     |                                                                                                 111
T  70 +                                                                                                  22  33
      |                                                                                                   22
S     |                                                                                                   121 33 3
U     |                                                                                                     11   33
R  60 +                                                                                                     2112
V     |                                                                                                       11 2
I     |                                                                                                          2232
V     |                                                                                                        1   1223
A  50 +                                                                                                            111
L     |                                                                                                              113
      |                                                                                                              2233
      |                                                                                                               1 13
   40 +                                                                                                                 111
      |                                                                                                                   3
      |                                                                                                               2 2 2
      |
   30 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 25 obs hidden.

                                                           VINYL TOLUENE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        100 PPM          = 2
                                                        300 PPM          = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                         1                                       32
      |
      |                           1                                       321         2
      |                                                                     1 3    1  22
   95 +
      |                                                                       3  3 1   2    2 1
      |                                                                          3     3    2 11
      |
   90 +                                                                                33      12   1
      |
      |                                                                                 3   3   2   1 1
      |                                                                                     3      32 1  1 2
P  85 +
E     |                                                                                                  1 1
R     |                                                                                            33      22
C     |
E  80 +                                                                                             3   3  11
N     |
T     |                                                                                                 33  1    1
      |                                                                                                  3 3     1 1
S  75 +
U     |                                                                                                    33    2 11
R     |                                                                                                     3 3    211
V     |
I  70 +                                                                                                       3     3121
V     |
A     |                                                                                                               211
L     |
   65 +
      |                                                                                                             33  11
      |                                                                                                              33  11
      |
   60 +                                                                                                               322
      |
      |
      |                                                                                                                 2 2
   55 +
      |                                                                                                                 33
      |                                                                                                                  33
      |
   50 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 14 obs hidden.

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