National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2123

TDMS Study 05075-02 Pathology Tables

NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97
Route: DOSED FEED                                                                                                 Time: 14:35:50




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57-41-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 7| 3| 3| 3| 4| 4| 3|             
                                           | 6| 6| 6| 6| 0| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 0| 9| 0| 0| 9| 9| 9| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |             X                    X     X                       X         |             
      Lymphoma Malignant Histiocytic       |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |          X  X                                                            |             
      Lymphoma Malignant Mixed             |       X                                X                                 |             
      Mesenteric, Lymphoma Malignant Mixed |                                                                   X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +        +            |             
      Lymphoma Malignant Histiocytic       |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Squamous Cell Papilloma              |          X                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                        +           +           +         |             
      Peridontal Tissue, Lymphoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 7| 3| 3| 3| 4| 4| 3|             
                                           | 6| 6| 6| 6| 0| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 0| 9| 0| 0| 9| 9| 9| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Malignant Histiocytic            |                                                    X                     |             
      Peridontal Tissue, Lymphoma          |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                              X                           |             
      Pheochromocytoma Complex             |                                                                          |             
      Pheochromocytoma Benign              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Adenoma               |                         X           X                       X        X   |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Follicular Cell, Adenoma             |                                                                   X  X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                X         |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Luteoma                              |                                                                   X      |             
      Lymphoma Malignant Histiocytic       |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Periovarian Tissue, Hemangiosarcoma  |                                                       X                  |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 7| 3| 3| 3| 4| 4| 3|             
                                           | 6| 6| 6| 6| 0| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 0| 9| 0| 0| 9| 9| 9| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Mixed                  |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |          X  X                                                            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Polyp Stromal                        |                                                                          |             
      Sarcoma Stromal, Multiple            |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          +  +                                                            |             
      Lymphoma Malignant Lymphocytic       |          X  X                                                            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Femoral, Hemangiosarcoma             |                                                       X                  |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Histiocytic                      |                                                    X                     |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |          X  X                                                            |             
      Vertebral, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |             X                                                            |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                    X                     |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |             X                                                            |             
      Mandibular, Lymphoma Malignant Mixed |       X                                                           X      |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 7| 3| 3| 3| 4| 4| 3|             
                                           | 6| 6| 6| 6| 0| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 0| 9| 0| 0| 9| 9| 9| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Histiocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +                                                              +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +        +                          +        +                 +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                 X     X                  |             
      Lymphoma Malignant Histiocytic       |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |          X  X                                                            |             
      Lymphoma Malignant Mixed             |    X  X                                X                             X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Myxoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 7| 3| 3| 3| 4| 4| 3|             
                                           | 6| 6| 6| 6| 0| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 0| 9| 0| 0| 9| 9| 9| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X     X              X              X                                   X|             
      Lymphoma Malignant Histiocytic       |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |          X  X                                                            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                              X                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +                             +      |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |          X  X                                                            |             
      Lymphoma Malignant Mixed             |    X  X                                X                          X  X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 2| 4| 3| 5| 4| 4| 1|            |
                                           | 0| 8| 0| 3| 3| 3| 3| 4| 4| 4| 9| 4| 4| 5| 1| 5| 5| 5| 6| 5| 1| 5| 6| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  45        |
      Lymphoma Malignant Histiocytic       |                                  X                                       |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leiomyoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Hepatocellular Adenoma               |                                                                   X      |          5 |
      Lymphoma Malignant Histiocytic       |                               X  X        X                              |          4 |
      Lymphoma Malignant Lymphocytic       |    X                                            X     X                  |          5 |
      Lymphoma Malignant Mixed             |          X                                                               |          3 |
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +  +     +  +     +                    +   |   8        |
      Lymphoma Malignant Histiocytic       |                               X  X        X                              |          4 |
      Lymphoma Malignant Lymphocytic       |                                                 X                    X   |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
      Lymphoma Malignant Histiocytic       |                                  X                                       |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                 X                        |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 2| 4| 3| 5| 4| 4| 1|            |
                                           | 0| 8| 0| 3| 3| 3| 3| 4| 4| 4| 9| 4| 4| 5| 1| 5| 5| 5| 6| 5| 1| 5| 6| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +                                      +                  |   5        |
      Peridontal Tissue, Lymphoma          |                                                                          |            |
          Malignant Histiocytic            |                                                                          |          1 |
      Peridontal Tissue, Lymphoma          |                                                                          |            |
          Malignant Lymphocytic            |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                  X        X                              |          2 |
      Lymphoma Malignant Lymphocytic       |    X                                            X                        |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                                  X                                       |          1 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Complex             |                                                 X                        |          1 |
      Pheochromocytoma Benign              |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  I  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Pars Distalis, Adenoma               |                                                 X        X               |          6 |
      Pars Distalis, Carcinoma             |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Lymphocytic       |                                                 X                        |          2 |
      Follicular Cell, Adenoma             |                                              X  X                        |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                              +                           |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 2| 4| 3| 5| 4| 4| 1|            |
                                           | 0| 8| 0| 3| 3| 3| 3| 4| 4| 4| 9| 4| 4| 5| 1| 5| 5| 5| 6| 5| 1| 5| 6| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cystadenoma                          |                                                                          |          1 |
      Granulosa Cell Tumor Benign          | X                                                                        |          1 |
      Luteoma                              |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                               X  X        X                              |          4 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
      Periovarian Tissue, Hemangiosarcoma  |                                                                          |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Lymphocytic            |       X           X                             X     X              X   |          5 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Mixed                  |                         X  X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                         X     X  X        X                              |          5 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
      Polyp Stromal                        |             X                                                            |          1 |
      Sarcoma Stromal, Multiple            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic       |                                                 X     X                  |          2 |
      Femoral, Hemangiosarcoma             |                                                                          |          1 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |    X                                                                     |          3 |
      Vertebral, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Histiocytic                      |                                  X                                       |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 2| 4| 3| 5| 4| 4| 1|            |
                                           | 0| 8| 0| 3| 3| 3| 3| 4| 4| 4| 9| 4| 4| 5| 1| 5| 5| 5| 6| 5| 1| 5| 6| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Histiocytic                      |                               X  X                                       |          2 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                         X     X  X                                       |          4 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |    X  X           X                                                      |          4 |
      Mandibular, Lymphoma Malignant Mixed | X                          X                                             |          4 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                        X                                 |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                               X  X                                       |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |       X                                                              X   |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                        X                                 |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                           X                              |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                        X                                 |          1 |
      Renal, Lymphoma Malignant Histiocytic|                               X  X                                       |          2 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +              +           +  +     +              +                  |  12        |
      Lymphoma Malignant Histiocytic       |                               X  X                                       |          2 |
      Lymphoma Malignant Lymphocytic       |    X              X                                                      |          3 |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Hemangiosarcoma                      |                         X                                                |          3 |
      Lymphoma Malignant Histiocytic       |                               X  X        X                              |          4 |
      Lymphoma Malignant Lymphocytic       |    X  X           X                             X                    X   |          7 |
      Lymphoma Malignant Mixed             | X        X              X  X                                             |          8 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  M  M|  42        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |    X  X           X                                      X               |          5 |
      Lymphoma Malignant Mixed             | X                       X                                                |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 2| 4| 3| 5| 4| 4| 1|            |
                                           | 0| 8| 0| 3| 3| 3| 3| 4| 4| 4| 9| 4| 4| 5| 1| 5| 5| 5| 6| 5| 1| 5| 6| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Adenocarcinoma                       |                                                             X            |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                  X                                       |          1 |
      Subcutaneous Tissue, Myxoma          |                                                                   X      |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                X         |          1 |
      Lymphoma Malignant Lymphocytic       |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |    +                                                                     |   1        |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          5 |
      Lymphoma Malignant Histiocytic       |                               X  X        X                              |          4 |
      Lymphoma Malignant Lymphocytic       |    X  X           X                             X                    X   |          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Gland        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |    X                                                  X                  |          2 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                          +                  |   2        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 2| 4| 3| 5| 4| 4| 1|            |
                                           | 0| 8| 0| 3| 3| 3| 3| 4| 4| 4| 9| 4| 4| 5| 1| 5| 5| 5| 6| 5| 1| 5| 6| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +        +        +     +                 +        +                  |   8        |
      Adenocarcinoma                       |                            X                                             |          1 |
      Adenoma                              |             X                                         X                  |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                               X  X        X                              |          4 |
      Lymphoma Malignant Lymphocytic       |    X                                            X                    X   |          4 |
      Lymphoma Malignant Mixed             | X        X              X                                                |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                                  X                                       |          1 |
      Lymphoma Malignant Lymphocytic       |                                                 X                        |          2 |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                         X     X  X        X                              |          5 |
      Lymphoma Malignant Lymphocytic       |    X  X           X                             X     X  X           X   |          9 |
      Lymphoma Malignant Mixed             | X        X              X  X                                             |          9 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 9| 3| 0| 3| 4| 3| 3| 7| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 6| 8| 1| 6| 3| 6| 8| 6| 7| 9| 7| 7| 4| 7| 7| 8| 8| 8| 0| 8| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +     +     A        +        +     +           +                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +     +     +        A        +     +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +     +     A        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +     +     +        +        +     +           +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Multiple            |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                         X     X                                   X      |             
      Hepatocellular Adenoma, Multiple     |                      X                                                   |             
      Lymphoma Malignant Histiocytic       |                   X                       X                              |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +     +        +        +     +           +                  |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +        +  +     +     +           +                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +        +  +     +     +           +                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Squamous Cell Papilloma              |          X     X                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +     +     +        +        +     +           +                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +     +        +        +     +           +                  |             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +     +     +        +        +     +           +                  |             
      Lymphoma Malignant Histiocytic       |                   X                       X                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +     +     +        +        +     +           +                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 9| 3| 0| 3| 4| 3| 3| 7| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 6| 8| 1| 6| 3| 6| 8| 6| 7| 9| 7| 7| 4| 7| 7| 8| 8| 8| 0| 8| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign              |             X                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +     A        +  +     +     M  +  +     +           +      |             
      Pars Distalis, Adenoma               | X           X                                X  X     X           X      |             
      Pars Intermedia, Adenoma             |                               X                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +     +        +        +     +           +                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +     +  +  +        +     +  +  +  +     +  +  +        +     +  +|             
      Choriocarcinoma                      |                                                                          |             
      Lymphoma Malignant Histiocytic       |                   X                                                      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +  +  +  +        +  +  +  +  +     +     +           +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Histiocytic       |                   X                                                      |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma Stromal                      |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +     +        +        +     +           +                  |             
      Femoral, Hemangiosarcoma             |                                                                          |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Histiocytic                      |                   X                       X                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +     +        +        +     +           M        +         |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                   X                       X                              |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                           X                              |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                           +                    +         |             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
      Lymphoma Malignant Mixed             |                                                                X         |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +     +        +     +           +        +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 9| 3| 0| 3| 4| 3| 3| 7| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 6| 8| 1| 6| 3| 6| 8| 6| 7| 9| 7| 7| 4| 7| 7| 8| 8| 8| 0| 8| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemangiosarcoma                      |                            X                                             |             
      Lymphoma Malignant Histiocytic       |                   X                       X                              |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X     X                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +     I     M        +        +     +           +                  |             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +     +     +        +        +     +           +                  |             
      Adenocarcinoma                       |    X                                                                     |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +     +     +        +        +     +           +                  |             
      Subcutaneous Tissue, Fibrosarcoma    |             X                                                            |             
      Subcutaneous Tissue, Hemangiosarcoma |                            X                                             |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +     +        +        +     +           +                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +     +     +        +        +     +     +     +  +               |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |       X                                                                  |             
      Alveolar/Bronchiolar Adenoma         |                                                          X               |             
      Alveolar/Bronchiolar Carcinoma       |                                                 X                        |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                   X                       X                              |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +     +     +        +        +     +           +                  |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |       X                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +     +     +        +        +     +           +                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 9| 3| 0| 3| 4| 3| 3| 7| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 6| 8| 1| 6| 3| 6| 8| 6| 7| 9| 7| 7| 4| 7| 7| 8| 8| 8| 0| 8| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
      Adenocarcinoma                       |       X                                                                  |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +     +     +        +        +     +           +                  |             
      Lymphoma Malignant Histiocytic       |                   X                       X                              |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +     +     M        +        +     +           +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                   X                       X                              |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X     X                                               X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 3|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 0| 6| 0| 4| 4| 8| 4| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 8| 6|            |
                                           | 0| 0| 0| 3| 3| 3| 7| 0| 7| 3| 4| 0| 4| 4| 4| 5| 5| 2| 5| 5| 3| 6| 6| 6| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                   +  +  +        +                 +        +        +  +|  16        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                   +  +  +        +                 +        +        +  A|  14        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                   +  +  +        +                 +        +        +  +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                   +  +  +        +                 +        +        +  A|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                   +  +  +        +                 +        +        +  +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                   +  +  +        +                 +        +        +  A|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                   +  +  +        +                 +        +     +  +  +|  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                   +  +  +        +                 +        +        +  A|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                   +  +  +        +                 +        +        +  +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                   +  +  +        +                 +        +     +  +  A|  16        |
      Lymphoma Malignant Mixed             |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma                      |                                                    X  X                  |          2 |
      Hemangiosarcoma, Multiple            |                                           X                              |          1 |
      Hepatocellular Carcinoma             |                                                                      X   |          1 |
      Hepatocellular Adenoma               |       X              X  X                    X     X                     |          8 |
      Hepatocellular Adenoma, Multiple     |                                           X                       X      |          3 |
      Lymphoma Malignant Histiocytic       |                                                             X            |          3 |
      Lymphoma Malignant Mixed             |                            X     X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +                                       |   2        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                   +  +  +        +                 +        +        +  A|  15        |
      Lymphoma Malignant Histiocytic       |                                                             X            |          1 |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                   +  +  M        +                 +        +        +  +|  15        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                   +  +  +        +           +     +        +        +  +|  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                   +  +  +        +           +     +        +        +  +|  20        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          1 |
      Squamous Cell Papilloma              |                                              X                           |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                   +  +  +        +                 +        +        +  +|  16        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                   +  +  +        +                 +        +        +  +|  16        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 3|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 0| 6| 0| 4| 4| 8| 4| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 8| 6|            |
                                           | 0| 0| 0| 3| 3| 3| 7| 0| 7| 3| 4| 0| 4| 4| 4| 5| 5| 2| 5| 5| 3| 6| 6| 6| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                   +  +  +        +                 +        +        +  +|  16        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                   +  +  +        +                 +        +        +  +|  16        |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                   +  +  +        +                 +        +        +  +|  16        |
      Pheochromocytoma Benign              |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                   +  +  +        +                 +        +        +  A|  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                   +  +  +        +                 +        +        +  +|  16        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +        +  +  M        +                 +        +        +  +|  19        |
      Pars Distalis, Adenoma               |          X                                                  X            |          8 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                   +  +  +        +                 +        +        +  +|  16        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +           +  +  +        +        +     +  +        +     +  +  +|  28        |
      Choriocarcinoma                      |                                                                         X|          1 |
      Lymphoma Malignant Histiocytic       |                                                             X            |          2 |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +  +  +  +  +  +  +        +  +  +  +  +  +  +        +  +  +  +  +|  36        |
      Hemangiosarcoma                      |                                                 X                        |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
      Sarcoma Stromal                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                   +  +  +        +                 +        +        +  +|  16        |
      Femoral, Hemangiosarcoma             |                         X                          X                     |          2 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Histiocytic                      |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +  +  M        +        +        +        +  +  +  +  +|  18        |
      Lumbar, Lymphoma Malignant Mixed     |                                  X                                       |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                             X            |          3 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                   X                                                      |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 3|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 0| 6| 0| 4| 4| 8| 4| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 8| 6|            |
                                           | 0| 0| 0| 3| 3| 3| 7| 0| 7| 3| 4| 0| 4| 4| 4| 5| 5| 2| 5| 5| 3| 6| 6| 6| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Histiocytic                      |                                                             X            |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                   X                                                      |          1 |
      Renal, Lymphoma Malignant Mixed      |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                      +                    +        +           +  +      |   7        |
      Hemangiosarcoma                      |                                           X                              |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                      X                                            X      |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +        +  +  +  +     +           +     +        +        +  +|  23        |
      Hemangiosarcoma                      |                         X                    X     X                     |          4 |
      Lymphoma Malignant Histiocytic       |                                                             X            |          3 |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Mixed             |          X                 X     X                                       |          5 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                   +  +  M        +                 +        +        +  M|  12        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                   +  +  M        +                 +        +        +  +|  15        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                   +  +  +        +                 +        +        +  +|  16        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |                         X                          X                     |          3 |
      Subcutaneous Tissue, Sarcoma         |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                   +  +  +        +                 +        +        +  +|  16        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                                       |   1        |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                   +  +  +        +                 +        +        +  +|  16        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                   +  +  +     +  +           +     +        +        +  +|  20        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 3|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 0| 6| 0| 4| 4| 8| 4| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 8| 6|            |
                                           | 0| 0| 0| 3| 3| 3| 7| 0| 7| 3| 4| 0| 4| 4| 4| 5| 5| 2| 5| 5| 3| 6| 6| 6| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Harderian Gland                  |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                                              X                           |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                      X   |          1 |
      Lymphoma Malignant Histiocytic       |                                                             X            |          3 |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                   +  +  +        +                 +        +        +  +|  16        |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Harderian Gland                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                   +  +  +        +                 +        +        +  +|  16        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       M                       +        +                                 |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +        +                          +      |   4        |
      Adenocarcinoma                       |                               X        X                                 |          3 |
      Adenoma                              |                                                                   X      |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                   +  +  +        +                 +        +        +  +|  16        |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                   +  +  +        +                 +        +        +  +|  15        |
      Lymphoma Malignant Mixed             |                                  X                                       |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                             X            |          3 |
      Lymphoma Malignant Lymphocytic       |                   X              X                                       |          2 |
      Lymphoma Malignant Mixed             |          X           X     X     X                                X      |          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 9| 1| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 4| 2| 4|             
                                           | 6| 6| 8| 0| 9| 6| 6| 4| 7| 7| 7| 7| 7| 8| 8| 5| 8| 8| 9| 9| 9| 9| 0| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    60 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +        +                 +     +  +                 +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +        +                 +     +  +                 +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +        +                       +                       +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                X                                                         |             
      Hepatocellular Carcinoma             |       X                                                     X            |             
      Hepatocellular Adenoma               |                                        X                 X  X     X      |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                X     X   |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                 X                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                       +                    +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +        +                       +                       +   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +        +     +              +  +                 +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +        +                    +  +                 +     +   |             
      Squamous Cell Papilloma              |       X                                   X                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +        +     +                 +                       +   |             
                                            __________________________________________________________________________|             
   Tongue                                  |          +                                                               |             
      Squamous Cell Carcinoma              |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +        +                       +                       +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +        +                       +                       +   |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +  +        +                       +                       +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 9| 1| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 4| 2| 4|             
                                           | 6| 6| 8| 0| 9| 6| 6| 4| 7| 7| 7| 7| 7| 8| 8| 5| 8| 8| 9| 9| 9| 9| 0| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    60 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +        +                       +              +        +   |             
      Pars Distalis, Adenoma               |                                                             X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +        +                       +                       +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +     +  +  +        +     +  +  +     +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                   X      |             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +  +  +  +           +        +  +  +              +  +  +   |             
      Lymphoma Malignant Histiocytic       |                X                                                     X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  A        +                       +                       +   |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Histiocytic                      |                                                                      X   |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Undifferentiated Cell Type       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +        +                       +                 +     +   |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                      X                                                   |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant Mixed |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                      X                                                   |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                      X                                                   |             
      Mediastinal, Mandibular, Sarcoma,    |                                                                          |             
           Metastatic, Eye                 |                                                                          |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +                 +                                         +         |             
      Lymphoma Malignant Histiocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  A  +     +        +           +  +        +     +  +  +  +   |             
      Lymphoma Malignant Histiocytic       |                                                                X     X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 9| 1| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 4| 2| 4|             
                                           | 6| 6| 8| 0| 9| 6| 6| 4| 7| 7| 7| 7| 7| 8| 8| 5| 8| 8| 9| 9| 9| 9| 0| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    60 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                 X                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +        +                       +                       +   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +     M        +                       +        +                  |             
      Adenocarcinoma                       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +        +                       +              +     +  +   |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                   X      |             
      Subcutaneous Tissue, Myxosarcoma     |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +        +                       +                       +   |             
      Femur, Osteoma                       |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +        +                       +                       +   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +        +        +           +  +                       +   |             
      Alveolar/Bronchiolar Adenoma         |          X                                                               |             
      Alveolar/Bronchiolar Carcinoma       |                               X                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
      Sarcoma, Metastatic, Eye             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +        +                       +                       +   |             
      Sarcoma, Metastatic, Eye             |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +        +                       +                       +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                     +  +      |             
      Adenoma                              |                                                                X  X      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 9| 1| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 4| 2| 4|             
                                           | 6| 6| 8| 0| 9| 6| 6| 4| 7| 7| 7| 7| 7| 8| 8| 5| 8| 8| 9| 9| 9| 9| 0| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    60 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +        +                    +  +                       +   |             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +        +                       +                       +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                X                                               X     X   |             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                 X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 4| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 8| 4| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 8| 4| 8| 6| 4| 4| 4| 4| 4|            |
                                           | 3| 6| 2| 0| 5| 8| 0| 3| 3| 3| 3| 4| 4| 4| 4| 1| 7| 5| 1| 5| 5| 5| 5| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    60 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +                             +  +     +  +               |  15        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +     +  +                             +  +     +  +               |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +  +              +        +     +  +     +  +        +      |  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     +  +              +        +     +  +     A  +        +      |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     +  +                             +  +     +  +               |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +  +                             +  +     A  +               |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +                             +  +     A  +               |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +  +                             +  +     A  +               |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +  +                             +  +     A  +               |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +     +  +                             +  +     A  +               |  14        |
      Lymphoma Malignant Mixed             |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      | X                                                                        |          2 |
      Hepatocellular Carcinoma             | X                                               X                        |          4 |
      Hepatocellular Adenoma               |                                  X     X  X     X           X  X         |         10 |
      Hepatocellular Adenoma, Multiple     |                                                                   X      |          1 |
      Lymphoma Malignant Histiocytic       |                X                                                         |          3 |
      Lymphoma Malignant Mixed             |       X                                                              X   |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                  +               |   5        |
      Lymphoma Malignant Mixed             |       X                                                                  |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +  +                             +  +     +  +               |  15        |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +  +                             +  +     M  +               |  14        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +  +                          +  +     +  +           +  +|  21        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +  +                          +  +     +  +           +  +|  20        |
      Squamous Cell Papilloma              |                   X                                                      |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +                             +  +     +  +               |  16        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +                             +  +     +  +               |  15        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     +  +                             +  +     M  +               |  14        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 4| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 8| 4| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 8| 4| 8| 6| 4| 4| 4| 4| 4|            |
                                           | 3| 6| 2| 0| 5| 8| 0| 3| 3| 3| 3| 4| 4| 4| 4| 1| 7| 5| 1| 5| 5| 5| 5| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    60 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  +                             +  +     M  +               |  14        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +  +                             +  +     M  +               |  14        |
      Pheochromocytoma Benign              |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  M  +     +  +                             +  +     +  +               |  14        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +     +  +                             +  +     A  +               |  14        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +                       +     +  +     M  +           +   |  17        |
      Pars Distalis, Adenoma               |                                        X                             X   |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +                             +  +     +  +               |  15        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  M  M     +        +|  36        |
      Cystadenoma                          |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                X                                                         |          2 |
      Lymphoma Malignant Mixed             |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +           +  +     +  +     +  +     +  +  +     +  +  +|  31        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +  +                             +  +     +  +               |  15        |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Histiocytic                      |                X                                                         |          2 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +                             +  +     M  +               |  16        |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                X                                                         |          1 |
      Mandibular, Lymphoma Malignant Mixed |       X                                                                  |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                X                                                         |          1 |
      Mediastinal, Lymphoma Malignant Mixed|       X                                                                  |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 4| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 8| 4| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 8| 4| 8| 6| 4| 4| 4| 4| 4|            |
                                           | 3| 6| 2| 0| 5| 8| 0| 3| 3| 3| 3| 4| 4| 4| 4| 1| 7| 5| 1| 5| 5| 5| 5| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    60 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Mandibular, Sarcoma,    |                                                                          |            |
           Metastatic, Eye                 |             X                                                            |          1 |
      Renal, Lymphoma Malignant Histiocytic|                X                                                         |          1 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +        +                                                         |   5        |
      Lymphoma Malignant Histiocytic       |                X                                                         |          2 |
      Lymphoma Malignant Mixed             |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  +              +              +  +     +  +  +  +     +  +|  27        |
      Lymphoma Malignant Histiocytic       |                X                                               X         |          4 |
      Lymphoma Malignant Mixed             |       X                                                              X   |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M     +  +                             M  +     M  +               |  11        |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +        +  +                             +  +     M  +        +      |  12        |
      Adenocarcinoma                       |                                                                   X      |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +  +                             +  +     +  +               |  17        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Myxosarcoma     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +                             +  +     +  +               |  16        |
      Femur, Osteoma                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  +                             +  +     +  +               |  15        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +                          +  +  +     +  +           +   |  20        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           | X                                               X                        |          2 |
      Lymphoma Malignant Histiocytic       |                X                                                         |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 4| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 8| 4| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 8| 4| 8| 6| 4| 4| 4| 4| 4|            |
                                           | 3| 6| 2| 0| 5| 8| 0| 3| 3| 3| 3| 4| 4| 4| 4| 1| 7| 5| 1| 5| 5| 5| 5| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    60 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                                      X   |          2 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                              X                           |          1 |
      Sarcoma, Metastatic, Eye             |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +  +                             +  +     +  +               |  15        |
      Sarcoma, Metastatic, Eye             |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +                             +  +     +  +               |  15        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   1        |
      Sarcoma                              |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                      +   |   4        |
      Adenoma                              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +                             +  +     +  +               |  16        |
      Lymphoma Malignant Histiocytic       |                X                                                         |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +  +                             +  +     +  +               |  15        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                X                       X                       X         |          6 |
      Lymphoma Malignant Mixed             |       X                                                              X   |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 6| 5| 5| 3| 3| 3| 3| 3| 4| 9| 4| 4|             
                                           | 6| 6| 6| 6| 7| 5| 1| 7| 7| 7| 8| 8| 8| 1| 6| 9| 8| 9| 9| 9| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                +  A                    +  +  +                    +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +  +                    +  +  +           +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +  +                    +  +  +           +        +      |             
      Leiomyosarcoma                       |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +     +  +                    +  +  +        +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +  +                    +  +  +                    +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +     +  +                    +  +  +        +           +      |             
      Lymphoma Malignant Mixed             |          X                                            X                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                X                                         X               |             
      Hepatocellular Adenoma               |       X                 X                                      X         |             
      Hepatocellular Adenoma, Multiple     |                                     X              X                     |             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
      Lymphoma Malignant Mixed             |                                                       X              X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +           +            |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +              +  +                    +  +  +     +           +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +              +  +                    +  +  +     +           +  +      |             
      Squamous Cell Papilloma              |                                                                          |             
      Squamous Cell Papilloma, Multiple    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +  +                    +  +  +     +              +      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +  +                    +  +  +                    +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +  +                    +  +  +                    +      |             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +  +                    +  +  +                    +      |             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +  +  +                 +  M  +                    +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +     +  +                 +  +  +  +           +        +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 6| 5| 5| 3| 3| 3| 3| 3| 4| 9| 4| 4|             
                                           | 6| 6| 6| 6| 7| 5| 1| 7| 7| 7| 8| 8| 8| 1| 6| 9| 8| 9| 9| 9| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |                                                          X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +  +                 +  +  +                    +      |             
      C-Cell, Carcinoma                    |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +        +  +  +     +              +  +  +     +     +  +  +  +      |             
      Cystadenoma                          |                                                                          |             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
      Lymphoma Malignant Mixed             |                                                             X            |             
                                            __________________________________________________________________________|             
   Uterus                                  |                +  +  +  +  +     +     +  +  +  +     +  +     +  +     +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +     +  +                    +  +  +        +           +      |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                                                          |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Histiocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                                       X                  |             
      Mandibular, Lymphoma Malignant Mixed |                                                       X                  |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |          X                                                               |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                       +                  |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +              +     +  +  +  +     +           +  +  +|             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
      Lymphoma Malignant Mixed             |                                                 X     X              X   |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +  +                    +  M  +                    +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 6| 5| 5| 3| 3| 3| 3| 3| 4| 9| 4| 4|             
                                           | 6| 6| 6| 6| 7| 5| 1| 7| 7| 7| 8| 8| 8| 1| 6| 9| 8| 9| 9| 9| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +  M                 +  +  +  +                    +      |             
      Adenocarcinoma                       |                                     X                             X      |             
                                            __________________________________________________________________________|             
   Skin                                    |                +  +                    +  +  +                    +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +  +                    +  +  +                    +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +  +                    +  +  +                    +      |             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +     +  +                    +  +  +                    +      |             
      Alveolar/Bronchiolar Adenoma         |          X                                                               |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
                                            __________________________________________________________________________|             
   Nose                                    |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +  +                    +  +  +                    +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +           +                                 |             
      Adenocarcinoma                       |                            X                                             |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                +  +                    +  +  +                    +      |             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +  +                    +  +  +                    +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
      Lymphoma Malignant Mixed             |          X                                      X     X     X        X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|            |
                             DAY ON TEST   | 3| 4| 3| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 7| 7|            |
                                           | 5| 3| 5| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 5| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +     +                 +  +                                      +  +  +|  12        |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +                 +  +                                      +  +  +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A     +                 +  +                                      +  +  +|  13        |
      Leiomyosarcoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A     +                 +  +                 +           +  +     +  +  +|  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A     +                 +  +                                      +  +  +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A     +                 +  +                 +              +     +  +  +|  14        |
      Lymphoma Malignant Mixed             |                                              X              X            |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A     +                 +  +                             +        +  +  +|  15        |
      Lymphoma Malignant Mixed             |                                                          X               |          3 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                                                             X        X   |          4 |
      Hepatocellular Adenoma               |                                     X     X     X                       X|          7 |
      Hepatocellular Adenoma, Multiple     |    X                          X                                X         |          5 |
      Lymphoma Malignant Histiocytic       |       X                                                        X         |          3 |
      Lymphoma Malignant Mixed             | X                                                           X            |          4 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                +     +   |   4        |
      Lymphoma Malignant Histiocytic       |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | A     +                 +  +                                      +  +  +|  12        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +                 +  +                                   +  +  +  +|  14        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | A     +  +              +  +  +  +  +  +                          +  +  +|  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | A     +  +              +  +  +  +  +  +                          +  +  +|  20        |
      Squamous Cell Papilloma              |                                     X  X                                 |          2 |
      Squamous Cell Papilloma, Multiple    |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | A     +  +              +  +     +                                +  +  +|  15        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +                 +  +                                      +  +  +|  13        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +                 +  +                                      +  +  +|  13        |
      Lymphoma Malignant Histiocytic       |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +                 +  +                                      +  +  +|  13        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|            |
                             DAY ON TEST   | 3| 4| 3| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 7| 7|            |
                                           | 5| 3| 5| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 5| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | A     +                 +  +                                      +  +  +|  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +                 +  +                       +              +  +  +|  17        |
      Pars Distalis, Adenoma               |                                                    X                     |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +                 +  +                                      +  +  +|  14        |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                               +                                          |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +  +  +  +        +  +  +  +     +        +                 +  +  +|  28        |
      Cystadenoma                          | X           X                                   X                        |          3 |
      Hemangioma                           |                                                                   X      |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +        +  +  +  +  +  +  +  +     +     +  +           +  +  +|  33        |
      Lymphoma Malignant Histiocytic       |       X  X                                                               |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +        +        +  +                       +     +  +  +  +  +  +|  20        |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Histiocytic                      |                                                                X         |          1 |
      Axillary, Lymphoma Malignant Mixed   | X                                                                        |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Histiocytic                      |                                                                X         |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Histiocytic                      |                                                                X         |          1 |
      Lumbar, Lymphoma Malignant Mixed     | X                                                                        |          2 |
      Mandibular, Lymphoma Malignant Mixed | X                                                                        |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                X         |          1 |
      Mediastinal, Lymphoma Malignant Mixed| X                                                                        |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                                X         |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|            |
                             DAY ON TEST   | 3| 4| 3| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 7| 7|            |
                                           | 5| 3| 5| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 5| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
      Renal, Lymphoma Malignant Histiocytic|                                                                X         |          1 |
      Renal, Lymphoma Malignant Mixed      | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                  +     +  +  +         |   6        |
      Lymphoma Malignant Histiocytic       |                                                                X         |          1 |
      Lymphoma Malignant Mixed             | X                                                  X     X  X            |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +              +  +     +                 +        +  +  +  +  +|  23        |
      Lymphoma Malignant Histiocytic       |          X                                                     X         |          3 |
      Lymphoma Malignant Mixed             | X                                X                 X        X            |          7 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M     +                 +  +                                      M  +  M|   9        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +                 +  +                                      +  +  +|  13        |
      Adenocarcinoma                       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +                 +  +                                      +  +  +|  13        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +                 +  +                                      +  +  +|  13        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +                 +  +                                      +  +  +|  13        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +                 +  +                 +                    +  +  +|  15        |
      Alveolar/Bronchiolar Adenoma         |                                              X                           |          2 |
      Alveolar/Bronchiolar Carcinoma       |                         X                                                |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +                 +  +                                      +  +  +|  13        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +     +                                       |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                  +                                       |   3        |
      Adenocarcinoma                       |                                                                          |          1 |
      Adenoma                              |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +                 +  +                                      +  +  +|  13        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  34                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|            |
                             DAY ON TEST   | 3| 4| 3| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 7| 7|            |
                                           | 5| 3| 5| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 5| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +                 +  +                                      +  +  +|  13        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |       X  X                                                     X         |          4 |
      Lymphoma Malignant Mixed             | X                                X           X     X     X  X            |         11 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 5| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 4| 3| 8| 3| 0| 3| 3| 3| 3| 4|             
                                           | 6| 6| 5| 6| 3| 6| 7| 7| 5| 7| 5| 7| 8| 8| 8| 3| 8| 7| 0| 2| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +     +           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +     A           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +     A           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +     A           +     A              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +     A           +     +              +     +  +  +               |             
      Leiomyosarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +     A           +     M              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +     A           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +     A           +     M              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +     A           +     +              +     +  +  +               |             
      Lymphoma Malignant Histiocytic       |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +     A           +     +              +     +  +  +               |             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               | X                 X              X  X           X     X     X  X  X     X|             
      Hepatocellular Adenoma, Multiple     |                            X                                             |             
      Lymphoma Malignant Histiocytic       |             X                                            X               |             
      Lymphoma Malignant Mixed             |                               X                             X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +              +                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +     A           +     +              +     +  +  +               |             
      Lymphoma Malignant Histiocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +     +           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +     A           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +     A           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +     A           +     +              +     +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +     +           +     +              +     +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +     +           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +     +           +     +              +     +  +  +               |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +     +           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +     A           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +     +           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +     +  +        +     +              +     +  +  +        +      |             
      Pars Distalis, Adenoma               |                X                                                  X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +     +           +     +              +     +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 5| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 4| 3| 8| 3| 0| 3| 3| 3| 3| 4|             
                                           | 6| 6| 5| 6| 3| 6| 7| 7| 5| 7| 5| 7| 8| 8| 8| 3| 8| 7| 0| 2| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +        +  +  +  +        +     +     +  +  +               |             
      Cystadenoma                          |                                                                          |             
      Lymphoma Malignant Histiocytic       |             X                                            X               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +           +  +  +     +  +     +  +  +  +  +  +  +        +|             
      Lymphoma Malignant Histiocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Polyp Stromal                        |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +     +           +     +              +     +  +  +               |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Histiocytic                      |                                                          X               |             
      Femoral, Lymphoma Malignant Mixed    |                               X                                          |             
      Vertebral, Lymphoma Malignant Mixed  |                               X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +     +     +     +              +     +  +  +     +         |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                                          X               |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                          X               |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant Mixed |                                                                X         |             
      Mediastinal, Lymphoma Malignant Mixed|                   X                                   X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                   +                                   +  +               |             
      Lymphoma Malignant Histiocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                   X                                   X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +     +  +  +  +  +     +              +     +  +  +  +  +         |             
      Lymphoma Malignant Histiocytic       |             X                                            X               |             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             |                   X           X                       X     X  X         |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +     A           +     +              +     +  +  +               |             
      Lymphoma Malignant Histiocytic       |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +     +           +     M              +     M  +  +               |             
                                            __________________________________________________________________________|             
   Skin                                    |       +     +           +     +              +     +  +  +               |             
      Subcutaneous Tissue, Fibrosarcoma    |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +     +           +     +              +     +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +     +           +     +              +     +  +  +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 5| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 4| 3| 8| 3| 0| 3| 3| 3| 3| 4|             
                                           | 6| 6| 5| 6| 3| 6| 7| 7| 5| 7| 5| 7| 8| 8| 8| 3| 8| 7| 0| 2| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +     +           +     +              +     +  +  +               |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +     +           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +     +           +     +              +     +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                    +  +                        |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                         X                    X  X                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +     +  +        +     +              +     +  +  +               |             
      Lymphoma Malignant Histiocytic       |                                                          X               |             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +     +           +     +              +     +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |             X                                            X               |             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             |                   X           X                       X     X  X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 0| 0| 0| 9| 3| 3| 4| 3| 3| 4| 4| 4| 4| 5| 5| 5| 0| 5| 6| 6| 6| 6| 6| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +        +                          +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          +        +                          +  +                        |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +        +  +                       +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +        +                          +  +                        |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +        +  +                       +  +                        |  12        |
      Leiomyosarcoma                       |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +        +                          +  +                        |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +        +                          +  +           +            |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +        +                          +  +                        |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +        +                          +  +                        |  11        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +        +                          +  +           +            |  12        |
      Adenocarcinoma                       |                                                             X            |          1 |
      Lymphoma Malignant Mixed             |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                            X                                X  X         |          3 |
      Hepatocellular Adenoma               | X                       X        X     X           X  X     X  X  X     X|         20 |
      Hepatocellular Adenoma, Multiple     |    X                                         X  X                    X   |          5 |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                   X           X                 X                        |          5 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                             +                        |   4        |
      Lymphoma Malignant Mixed             |                   X                             X                        |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +        +                       +  +  +                        |  12        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +        +                          +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +        +     +                    +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +        +     +                    +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +        +                          +  +                        |  11        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +        +                          +  +                        |  12        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |          +        +                          +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +        +                          +  +                        |  12        |
      Lymphoma Malignant Mixed             |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +        +                          +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +        +                          +  +                        |  11        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 0| 0| 0| 9| 3| 3| 4| 3| 3| 4| 4| 4| 4| 5| 5| 5| 0| 5| 6| 6| 6| 6| 6| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +        +                          +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +        +                          +  +                        |  14        |
      Pars Distalis, Adenoma               |                                              X                           |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +        +                          +  +                        |  12        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |          +  +     +     +        +        +  +  +  +  +     +     +      |  25        |
      Cystadenoma                          |                                                    X                     |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +  +  +  +  +  +  +  +  +           +  +  +     +           +  +  +|  33        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                 X                        |          1 |
      Polyp Stromal                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +        +                          +  +                        |  12        |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Femoral, Lymphoma Malignant Mixed    |                   X                                                      |          2 |
      Vertebral, Lymphoma Malignant Mixed  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +        +                          +  +  +                     |  15        |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                    X                     |          1 |
      Mandibular, Lymphoma Malignant Mixed |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                   X                                                      |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                 +                        |   4        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                 X                        |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +        +           +     +     +  +  +           +  +         |  23        |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 0| 0| 0| 9| 3| 3| 4| 3| 3| 4| 4| 4| 4| 5| 5| 5| 0| 5| 6| 6| 6| 6| 6| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                   X           X     X                                    |          8 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +        +                          +  +                        |  11        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          M        +                          +  +                        |   9        |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +        +                          +  +                        |  12        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +        +                          +  +                        |  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +        +                          +  +        +               |  13        |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Harderian Gland                  |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +        +                       +  +  +                        |  13        |
      Alveolar/Bronchiolar Carcinoma       |                                           X                              |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                   X                             X                        |          3 |
                                            __________________________________________________________________________|____________|
   Nose                                    |          +        +                          +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +        +                          +  +                        |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                          +               |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                          +               |   4        |
      Adenocarcinoma                       |                                                          X               |          1 |
      Adenoma                              |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +        +                    +     +  +                        |  14        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                        X        X                        |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +        +                          M  +                        |  11        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 0| 0| 0| 9| 3| 3| 4| 3| 3| 4| 4| 4| 4| 5| 5| 5| 0| 5| 6| 6| 6| 6| 6| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                                    X                     |          2 |
      Lymphoma Malignant Mixed             |                   X           X     X  X        X                        |         10 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 6| 4| 6| 6| 7| 7| 7| 0| 2| 7| 8| 8| 8| 5| 8| 9| 9| 6| 9| 9| 9| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       A                 +  +              +           +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       A                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       A                 +  +              A           +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       A                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       A                 +  +              A           +                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       A                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       A                 +  +              A           +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       A                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       A                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                   X                    X        X           X            |             
      Hepatocellular Adenoma, Multiple     |             X                 X  X                                       |             
      Lymphoma Malignant Mixed             |                                                    X                    X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       A                 +  +              +           +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       A                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  A     +  +     +  +  +     +        +  +        +                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  A     +  +     +  +  +     +        +  +        +                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       A     +  +     +  +  +              +           +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +                 +  +              +           +                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       A                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       A                 +  +              +           +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       A                 +  +              +           +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       A                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       A     +           +  +              A           +  +        M  +  +|             
      Lymphoma Malignant Mixed             |                                                                         X|             
      Pars Distalis, Adenoma               |             X                                            X           X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       A                 +  +              +           +                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 6| 4| 6| 6| 7| 7| 7| 0| 2| 7| 8| 8| 8| 5| 8| 9| 9| 6| 9| 9| 9| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  A  +     +     +  +  +  +  +        +           +     +  +  +     +|             
      Cystadenoma                          |                      X                                                   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  A     +  +        +  +        +     +     +  +  +     +        +   |             
      Sarcoma Stromal                      |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       A                 +  +              +           +                  |             
      Femoral, Lymphoma Malignant Mixed    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       A                 +  +     +     +  +        +  +                  |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                                    X                     |             
      Mandibular, Adenocarcinoma,          |                                                                          |             
          Metastatic, Harderian Gland      |                            X                                             |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                        X                                 |             
      Mandibular, Lymphoma Malignant Mixed |                         X                                                |             
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                  X                                       |             
      Mediastinal, Osteosarcoma,           |                                                                          |             
          Metastatic, Uncertain Primary    |                                                                          |             
          Site                             |                                                       X                  |             
      Renal, Lymphoma Malignant Mixed      |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                         +              +           +                     |             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                         X                          X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  A           +     +  +     +  +  +  +     +  +  +  +        +     +|             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                         X        X              X  X     X              X|             
                                            __________________________________________________________________________|             
   Thymus                                  |       A                 +  +              A           +                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +                                   +           +                  |             
                                            __________________________________________________________________________|             
   Skin                                    |       +                 +  +              +           +                  |             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +                 +  +              +           +                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 6| 4| 6| 6| 7| 7| 7| 0| 2| 7| 8| 8| 8| 5| 8| 9| 9| 6| 9| 9| 9| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +                 +  +              +           +                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +                 +  +              +           +                  |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                            X                                             |             
      Alveolar/Bronchiolar Adenoma         |                                                       X                  |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Mixed             |                         X                                                |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                       X                  |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +                 +  +              +           +                  |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                            X                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +                 +  +              +           +                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                   +         |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                            X                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                 +                 +         |             
      Adenocarcinoma                       |                            X                                   X         |             
      Adenoma                              |                                              X                           |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +                 +  +              +           +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                       X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       A                 +  +              +           +                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                         X        X              X  X     X              X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 4| 6| 4| 4| 4| 4| 4| 4| 4| 8| 3| 1| 4| 4| 4| 4| 4| 7| 4| 4| 4| 8| 4| 4| 7|            |
                                           | 0| 5| 3| 3| 3| 3| 4| 4| 4| 0| 0| 7| 4| 5| 5| 5| 5| 4| 6| 6| 6| 9| 6| 6| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +                       +  +  +                 +           +        +|  12        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +                       +  +  +                 +           +        +|  11        |
      Lymphoma Malignant Mixed             |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +        +     +        +  +  +                 +           +        +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +        +     +        +  +  +                 +           +        M|  11        |
      Lymphoma Malignant Mixed             |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +                       +  +  +                 +           +        +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +                       +  +  +                 +           +        +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +                       +  +  +                 +           +        +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +                       +  +  +                 +           +        +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +                       +  +  +                 +           +        +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +                       +  +  +                 +           +        +|  11        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hepatocellular Carcinoma             | X                                                                        |          1 |
      Hepatocellular Adenoma               |                   X              X                          X     X      |          8 |
      Hepatocellular Adenoma, Multiple     |             X                                                           X|          5 |
      Lymphoma Malignant Mixed             |                            X  X                    X                 X   |          6 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +  +                                          |   2        |
      Lymphoma Malignant Mixed             |                            X  X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +                       +  +  +                 +           +        +|  11        |
      Lymphoma Malignant Mixed             |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +                       +  +  +                 +           +        +|  11        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +                       +  +  +                 +           +        +|  17        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +                       +  +  +                 +           +         |  16        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +                       +  +  +                 +           +         |  13        |
      Lymphoma Malignant Mixed             |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +                       +  +  +                 +           +        +|  13        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +                       +  +  +                 +           +        +|  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +                       +  +  +                 +           +        +|  11        |
      Lymphoma Malignant Mixed             |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +                       +  +  +                 +           +        +|  11        |
      Lymphoma Malignant Mixed             |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +                       +  +  +                 +           +        +|  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +                       +  +  M                 +           +        +|  11        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 4| 6| 4| 4| 4| 4| 4| 4| 4| 8| 3| 1| 4| 4| 4| 4| 4| 7| 4| 4| 4| 8| 4| 4| 7|            |
                                           | 0| 5| 3| 3| 3| 3| 4| 4| 4| 0| 0| 7| 4| 5| 5| 5| 5| 4| 6| 6| 6| 9| 6| 6| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +           +     +     +  +  M                 M           +  +     +|  15        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Pars Distalis, Adenoma               |                X     X                                         X  X      |          8 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +                       +  +  +                 +           +        +|  11        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +        +     +     +  +  +     +        +  +     +  +  +  +     +|  30        |
      Cystadenoma                          |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                            X  X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +     +  +     +  +  +  +  +  +        +  +     +  +  +  +  +  +  +  +|  32        |
      Sarcoma Stromal                      |                                                          X               |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +                       +  +  +                 +           +        +|  11        |
      Femoral, Lymphoma Malignant Mixed    |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +              +        +  +  +     +  +        +  +        +  +  +  +|  20        |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                               X                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                               X                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                            X                                             |          2 |
      Mandibular, Adenocarcinoma,          |                                                                          |            |
          Metastatic, Harderian Gland      |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mandibular, Lymphoma Malignant Mixed |                            X  X                    X                     |          4 |
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |    X                                                                     |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                            X  X                    X                 X   |          5 |
      Mediastinal, Osteosarcoma,           |                                                                          |            |
          Metastatic, Uncertain Primary    |                                                                          |            |
          Site                             |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                            X  X                    X                     |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +        +  +                    +  +           +      |   9        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                            X  X                    X              X      |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  47                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 4| 6| 4| 4| 4| 4| 4| 4| 4| 8| 3| 1| 4| 4| 4| 4| 4| 7| 4| 4| 4| 8| 4| 4| 7|            |
                                           | 0| 5| 3| 3| 3| 3| 4| 4| 4| 0| 0| 7| 4| 5| 5| 5| 5| 4| 6| 6| 6| 9| 6| 6| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +                       +  +  +  +  +        +  +  +        +  +  +  +|  27        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                            X  X                 X  X              X      |         11 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +                       +  +  +                 +           +        +|  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +                                               +                     |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +                       +  +  +                 +        +  +        +|  13        |
      Squamous Cell Carcinoma              |                                                             X            |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +                       +  +  +                 +           +        +|  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +                       +  +  +                 +           +        +|  12        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +                       +  +  +                 +           +        +|  13        |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Harderian Gland                  |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         | X                                                                        |          2 |
      Alveolar/Bronchiolar Carcinoma       |    X                                                                     |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           | X                                                                        |          1 |
      Lymphoma Malignant Mixed             |                            X  X                    X                     |          4 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +                       +  +  +                 +           +        +|  12        |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Harderian Gland                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +                       +  +  +                 +           +        +|  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                        +                                 |   3        |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Harderian Gland                  |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  48                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 4| 6| 4| 4| 4| 4| 4| 4| 4| 8| 3| 1| 4| 4| 4| 4| 4| 7| 4| 4| 4| 8| 4| 4| 7|            |
                                           | 0| 5| 3| 3| 3| 3| 4| 4| 4| 0| 0| 7| 4| 5| 5| 5| 5| 4| 6| 6| 6| 9| 6| 6| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                        +                                 |   4        |
      Adenocarcinoma                       |                                                                          |          2 |
      Adenoma                              |                                        X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +                       +  +  +                 +           +        +|  12        |
      Lymphoma Malignant Mixed             |                               X                                          |          1 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +                       +  +  +                 +           +        +|  11        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                            X  X                 X  X              X  X   |         12 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  49                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 0| 3| 8| 7| 8| 8| 4| 8| 9| 0| 7| 9| 9| 9| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |          X              X     X     X  X                          X     X|             
      Hepatocellular Adenoma               |    X  X           X        X              X     X  X           X     X  X|             
      Hepatocellular Adenoma, Multiple     |                      X           X                                       |             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                        X                 X               |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +           +  +               |             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                          X               |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mast Cell Tumor NOS                  |                X                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 0| 3| 8| 7| 8| 8| 4| 8| 9| 0| 7| 9| 9| 9| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Mast Cell Tumor NOS                  |                X                                                         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                        +                    +            |             
      Peridontal Tissue, Lymphoma          |                                                                          |             
          Malignant Undifferentiated Cell  |                                                                          |             
          Type                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                         X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  I  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Pars Distalis, Adenoma               |    X                                                                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |             X                                                            |             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Teratoma                             |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Lymphocytic            |                                                             X            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                     X                                    |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 0| 3| 8| 7| 8| 8| 4| 8| 9| 0| 7| 9| 9| 9| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Femoral, Lymphoma Malignant Mixed    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                             X            |             
      Mandibular, Lymphoma Malignant Mixed |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                             X            |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                             X            |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                  +                       +  +            |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                                          X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |       X                                X                 X               |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  I  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  M  +  +  +  +  +  M  M  +  +  +  M  +  +  +  M  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 0| 3| 8| 7| 8| 8| 4| 8| 9| 0| 7| 9| 9| 9| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                   X     X|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                     X                 X                  |             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |       X                                X                 X               |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 3| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 8| 1| 4| 4| 4| 4| 4| 3| 4|            |
                                           | 0| 3| 3| 3| 3| 0| 4| 2| 4| 7| 4| 4| 5| 5| 5| 5| 7| 9| 6| 6| 6| 6| 6| 7| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    600 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  45        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic       |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |       X     X                    X                                       |         10 |
      Hepatocellular Adenoma               | X     X        X        X  X  X           X        X                    X|         19 |
      Hepatocellular Adenoma, Multiple     |    X              X  X                 X        X                        |          7 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
      Lymphoma Malignant Mixed             |                               X                             X            |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +     +                                               +   |   6        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                X                                                     X   |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
      Lymphoma Malignant Mixed             |                                                             X            |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  54                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 3| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 8| 1| 4| 4| 4| 4| 4| 3| 4|            |
                                           | 0| 3| 3| 3| 3| 0| 4| 2| 4| 7| 4| 4| 5| 5| 5| 5| 7| 9| 6| 6| 6| 6| 6| 7| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    600 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mast Cell Tumor NOS                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
      Mast Cell Tumor NOS                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +     +  +     +  +              +  +           +     +     +         |  12        |
      Peridontal Tissue, Lymphoma          |                                                                          |            |
          Malignant Undifferentiated Cell  |                                                                          |            |
          Type                             |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pheochromocytoma Benign              |                                     X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  44        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
      Pars Distalis, Adenoma               |    X                                                  X                  |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Follicular Cell, Adenoma             |          X     X                                               X         |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cystadenoma                          |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  55                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 3| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 8| 1| 4| 4| 4| 4| 4| 3| 4|            |
                                           | 0| 3| 3| 3| 3| 0| 4| 2| 4| 7| 4| 4| 5| 5| 5| 5| 7| 9| 6| 6| 6| 6| 6| 7| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    600 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
      Teratoma                             |                            X                                             |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Lymphocytic            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                     X                          X         |          3 |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
      Polyp Stromal                        |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                +     +        +                                          |   3        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                X                                                         |          1 |
      Femoral, Lymphoma Malignant Mixed    |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                X                                                         |          2 |
      Mandibular, Lymphoma Malignant Mixed |                                                             X            |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                X                                                         |          2 |
      Mediastinal, Lymphoma Malignant Mixed|                                                             X            |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                      X                                                   |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                                             X            |          1 |
      Renal, Lymphoma Malignant Mixed      |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +        +                                                     +   |   6        |
      Lymphoma Malignant Lymphocytic       |                X                                                     X   |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                X         |          2 |
      Lymphoma Malignant Lymphocytic       |                X                                                     X   |          3 |
      Lymphoma Malignant Mixed             |                               X                             X            |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  56                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 3| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 8| 1| 4| 4| 4| 4| 4| 3| 4|            |
                                           | 0| 3| 3| 3| 3| 0| 4| 2| 4| 7| 4| 4| 5| 5| 5| 5| 7| 9| 6| 6| 6| 6| 6| 7| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    600 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          2 |
      Lymphoma Malignant Mixed             |                               X                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  M  +|  39        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                                          X               |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          2 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                X                                                     X   |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  57                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 3| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 8| 1| 4| 4| 4| 4| 4| 3| 4|            |
                                           | 0| 3| 3| 3| 3| 0| 4| 2| 4| 7| 4| 4| 5| 5| 5| 5| 7| 9| 6| 6| 6| 6| 6| 7| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    600 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          2 |
      Lymphoma Malignant Mixed             |                                                             X            |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                     X                          X         |          4 |
      Lymphoma Malignant Lymphocytic       |                X                                                     X   |          3 |
      Lymphoma Malignant Mixed             |                               X                             X            |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 4| 4| 4| 4|             
                                           | 1| 6| 6| 6| 6| 7| 8| 7| 6| 7| 7| 8| 8| 8| 8| 3| 9| 7| 9| 9| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    600 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatoblastoma                       |                                                                   X      |             
      Hepatocellular Carcinoma             |                                                       X              X   |             
      Hepatocellular Carcinoma, Multiple   |                      X                                         X         |             
      Hepatocellular Adenoma               |    X     X                 X     X  X  X                       X         |             
      Hepatocellular Adenoma, Multiple     | X                       X     X                                   X      |             
      Lymphoma Malignant Histiocytic       |                   X                                X                     |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                         X                                         X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +     +                                                |             
      Lymphoma Malignant Histiocytic       |                   X                                                      |             
      Lymphoma Malignant Mixed             |                         X                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                      X  X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                         X                                                |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                      X  X                                                |             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +     +     +           +              +     +         |             
      Peridontal Tissue, Lymphoma          |                                                                          |             
          Malignant Histiocytic            |                                                                          |             
      Peridontal Tissue, Lymphoma          |                                                                          |             
          Malignant Mixed                  |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 4| 4| 4| 4|             
                                           | 1| 6| 6| 6| 6| 7| 8| 7| 6| 7| 7| 8| 8| 8| 8| 3| 9| 7| 9| 9| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    600 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  A  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  I  +  +  +|             
      Pars Distalis, Adenoma               |                                                          X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                         X                                                |             
      Follicular Cell, Adenoma             |                                                 X                        |             
      Follicular Cell, Adenoma, Multiple   |                                                          X  X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |       X                       X                                          |             
      Luteoma                              |                               X                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Histiocytic            |                   X                                                      |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Lymphocytic            |                               X                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Mixed                  |                      X  X                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                       X                  |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                               X                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                   +                                                      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Histiocytic                      |                                                    X                     |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                               X                                          |             
      Femoral, Lymphoma Malignant Mixed    |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 4| 4| 4| 4|             
                                           | 1| 6| 6| 6| 6| 7| 8| 7| 6| 7| 7| 8| 8| 8| 8| 3| 9| 7| 9| 9| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    600 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Lymphoma Malignant Mixed   |                      X                                                   |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |          X                    X                                          |             
      Mandibular, Lymphoma Malignant Mixed |                      X  X              X                                 |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                    X                     |             
      Mediastinal, Lymphoma Malignant Mixed|                      X                                                   |             
      Renal, Lymphoma Malignant Mixed      |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +                       +              +                                 |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                         X              X                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                   X                                                      |             
      Lymphoma Malignant Lymphocytic       |                               X     X                                    |             
      Lymphoma Malignant Mixed             |                      X  X              X                          X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Lymphoma Malignant Histiocytic       |                   X                                                      |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                      X  X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  M  M  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                         X                                                |             
      Subcutaneous Tissue, Fibrosarcoma    |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
      Lymphoma Malignant Mixed             |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 4| 4| 4| 4|             
                                           | 1| 6| 6| 6| 6| 7| 8| 7| 6| 7| 7| 8| 8| 8| 8| 3| 9| 7| 9| 9| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    600 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                   X                                X                     |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                         X                                                |             
      Mediastinum, Hepatocellular          |                                                                          |             
          Carcinoma, Metastatic, Liver     |                                                       X                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
      Adenoma                              |                                                                          |             
      Lymphoma Malignant Mixed             |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                   X                                                      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                      X  X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                   X                                X                     |             
      Lymphoma Malignant Lymphocytic       |          X                    X     X                                    |             
      Lymphoma Malignant Mixed             |                      X  X              X                          X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 6| 4| 8| 0| 4| 4| 4| 8| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 4| 2| 4| 2|            |
                                           | 3| 3| 3| 4| 3| 6| 9| 3| 4| 4| 4| 4| 4| 0| 9| 5| 5| 5| 5| 6| 6| 6| 9| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    600 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  45        |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatoblastoma                       |                                                                          |          1 |
      Hepatocellular Carcinoma             |                      X        X     X  X  X  X     X                     |          9 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          2 |
      Hepatocellular Adenoma               |    X     X  X  X           X     X        X     X     X                  |         16 |
      Hepatocellular Adenoma, Multiple     |                                              X                    X      |          6 |
      Lymphoma Malignant Histiocytic       |                X        X                                               X|          5 |
      Lymphoma Malignant Lymphocytic       |                                                          X               |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +  +     +                                               +|   6        |
      Lymphoma Malignant Histiocytic       |                X  X     X                                               X|          5 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                X                                                        X|          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +                             +     +                     |   9        |
      Peridontal Tissue, Lymphoma          |                                                                          |            |
          Malignant Histiocytic            |                X                                                         |          1 |
      Peridontal Tissue, Lymphoma          |                                                                          |            |
          Malignant Mixed                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  63                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 6| 4| 8| 0| 4| 4| 4| 8| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 4| 2| 4| 2|            |
                                           | 3| 3| 3| 4| 3| 6| 9| 3| 4| 4| 4| 4| 4| 0| 9| 5| 5| 5| 5| 6| 6| 6| 9| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    600 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
      Pheochromocytoma Malignant           |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | I  +  I  +  +  +  +  +  +  +  +  +  +  I  +  +  +  M  +  +  +  +  +  I  +|  41        |
      Pars Distalis, Adenoma               |    X                                                  X                  |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                     X                                    |          2 |
      Follicular Cell, Adenoma, Multiple   |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  49        |
      Cystadenoma                          |                                                                          |          2 |
      Luteoma                              |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Histiocytic            |                         X                                                |          2 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Lymphocytic            |                                                                          |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Mixed                  |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                X  X                                                      |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                +                                                         |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  64                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 6| 4| 8| 0| 4| 4| 4| 8| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 4| 2| 4| 2|            |
                                           | 3| 3| 3| 4| 3| 6| 9| 3| 4| 4| 4| 4| 4| 0| 9| 5| 5| 5| 5| 6| 6| 6| 9| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    600 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Femoral, Lymphoma Malignant Mixed    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Histiocytic                      |                X  X                                                      |          2 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                                         X|          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
      Mandibular, Lymphoma Malignant Mixed |                                                                          |          3 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                         X|          2 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                         +           +                                   +|   6        |
      Lymphoma Malignant Histiocytic       |                         X                                               X|          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                X        X                                               X|          4 |
      Lymphoma Malignant Lymphocytic       |                                                          X               |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|  45        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                    X     X               |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  65                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 6| 4| 8| 0| 4| 4| 4| 8| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 4| 2| 4| 2|            |
                                           | 3| 3| 3| 4| 3| 6| 9| 3| 4| 4| 4| 4| 4| 0| 9| 5| 5| 5| 5| 6| 6| 6| 9| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    600 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |    X                                                                     |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                           X  X                           |          2 |
      Lymphoma Malignant Histiocytic       |                X                                                        X|          4 |
      Lymphoma Malignant Lymphocytic       |                                                          X               |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Mediastinum, Hepatocellular          |                                                                          |            |
          Carcinoma, Metastatic, Liver     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                          +               |   2        |
      Adenoma                              |                                                          X               |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                X                                                        X|          3 |
      Lymphoma Malignant Lymphocytic       |                                                          X               |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  66                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 6| 4| 8| 0| 4| 4| 4| 8| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 4| 2| 4| 2|            |
                                           | 3| 3| 3| 4| 3| 6| 9| 3| 4| 4| 4| 4| 4| 0| 9| 5| 5| 5| 5| 6| 6| 6| 9| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    600 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                X  X     X                                               X|          6 |
      Lymphoma Malignant Lymphocytic       |                                                    X     X               |          5 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  67                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 8| 3| 0| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 9| 4| 4| 4| 5| 5| 5| 0| 5| 6| 0| 6| 9| 8| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                            X                                X     X     X|             
      Hemangiosarcoma, Multiple            |                         X                                                |             
      Hepatocellular Carcinoma             | X                       X        X     X              X                  |             
      Hepatocellular Carcinoma, Multiple   |                X                                                         |             
      Hepatocellular Adenoma               |    X     X                                X  X  X  X           X         |             
      Hepatocellular Adenoma, Multiple     |             X  X     X                                X                  |             
      Lymphoma Malignant Histiocytic       |                                           X  X                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                       +      |             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                              X                           |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +        +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corticomedullary Junction,           |                                                                          |             
          Hepatocellular Carcinoma,        |                                                                          |             
          Metastatic, Liver                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 8| 3| 0| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 9| 4| 4| 4| 5| 5| 5| 0| 5| 6| 0| 6| 9| 8| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +                          +                                    |             
      Adenoma                              |          X                                                               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +              +                 +                          +            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hemangiosarcoma             |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                           X                              |             
      Inguinal, Lymphoma Malignant Mixed   |                                                             X            |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mandibular, Fibrosarcoma, Metastatic,|                                                                          |             
           Skin                            |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant Mixed |                                                             X            |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                    X                     |             
      Pancreatic, Lymphoma Malignant Mixed |                                  X                                       |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                  X                          X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +        +  +           +  +  +  +           +  +  +  +  +     +   |             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                                  X     X                    X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      | X                       X                                                |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                         X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 8| 3| 0| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 9| 4| 4| 4| 5| 5| 5| 0| 5| 6| 0| 6| 9| 8| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                         +                                                |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X                                         X        X  X  X            |             
      Alveolar/Bronchiolar Carcinoma       |                   X                                                  X   |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                         X              X                                 |             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +        +                                                            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +  +  +              +                                          |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |          X  X                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                           X  X                           |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                                  X     X                    X           X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 7| 4| 4| 7| 4| 4| 6| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 3| 1| 1| 3| 1| 1| 8| 2| 2| 7| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 0| 1| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                   X              X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          4 |
      Hemangiosarcoma, Multiple            |                                                                          |          1 |
      Hepatocellular Carcinoma             |                            X     X     X  X  X                       X   |         11 |
      Hepatocellular Carcinoma, Multiple   |             X                                                            |          2 |
      Hepatocellular Adenoma               |    X        X  X  X                                         X  X  X      |         14 |
      Hepatocellular Adenoma, Multiple     |                                                          X               |          5 |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +                                          |   3        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +        +     +  +     +  +  +           +  +  +  +  +     +     +|  36        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                   X      |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Corticomedullary Junction,           |                                                                          |            |
          Hepatocellular Carcinoma,        |                                                                          |            |
          Metastatic, Liver                |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  71                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 7| 4| 4| 7| 4| 4| 6| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 3| 1| 1| 3| 1| 1| 8| 2| 2| 7| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 0| 1| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  I  +  I  +  +  +  +  I  +  M  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                           +              +  +            |   5        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                   +           +  +        +                          +   |   9        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Hemangiosarcoma             |                                                                   X      |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                  X                                       |          1 |
      Mandibular, Fibrosarcoma, Metastatic,|                                                                          |            |
           Skin                            |          X                                                               |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                   X                                                      |          1 |
      Mandibular, Lymphoma Malignant Mixed |                                                                      X   |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                   X                                                      |          2 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                      X   |          2 |
      Renal, Lymphoma Malignant Lymphocytic|                                  X                                       |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  72                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 7| 4| 4| 7| 4| 4| 6| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 3| 1| 1| 3| 1| 1| 8| 2| 2| 7| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 0| 1| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +  +     +              +  +  +  +                       +  +   |  22        |
      Hemangiosarcoma                      |                                                                   X      |          1 |
      Lymphoma Malignant Lymphocytic       |                   X              X        X                              |          4 |
      Lymphoma Malignant Mixed             |                                                                      X   |          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma                      |                X                                                  X      |          4 |
      Lymphoma Malignant Lymphocytic       |                   X                                X                     |          2 |
      Lymphoma Malignant Mixed             |                                                                      X   |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  I  +  +  +  +  M  I  M  +  +  +  +  M  +  +  +  +  +  +  M  M  +|  37        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Fibrosarcoma    |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                         X                                                |          6 |
      Alveolar/Bronchiolar Carcinoma       |       X                                                                 X|          4 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |             X              X                 X                       X   |          6 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +  +     +                 +                                   +      |   9        |
      Adenocarcinoma                       |       X                                                                  |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  73                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 7| 4| 4| 7| 4| 4| 6| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 3| 1| 1| 3| 1| 1| 8| 2| 2| 7| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 0| 1| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |             X                 X                                   X      |          5 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                   X              X        X        X                     |          5 |
      Lymphoma Malignant Mixed             |                                                                      X   |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  74                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 5| 6| 5| 0| 5| 5| 6| 6| 6| 6| 7| 6| 7| 7| 3| 7| 8| 8| 3| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                A     +                       M        +           M      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                A     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                A     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                A     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                A     +                       +        +           +      |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                A     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                A     +                       +        +           +      |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                A     +                       +        +           +      |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                A     +                       +        +           +      |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                      X   |             
      Hemangiosarcoma, Multiple            |                   X                                                      |             
      Hepatocellular Carcinoma             | X  X                 X                 X        X     X              X   |             
      Hepatocellular Carcinoma, Multiple   |                                              X                           |             
      Hepatocellular Adenoma               |                   X                                               X     X|             
      Hepatocellular Adenoma, Multiple     |    X        X           X     X  X                          X        X   |             
      Hepatocholangiocarcinoma             |                                                                          |             
      Lymphoma Malignant Histiocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             | X                                                     X              X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Hepatocholangiocarcinoma, Metastatic |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                A     +                       +        +           +      |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +     M                       +        +           +      |             
                                            __________________________________________________________________________|             
   Stomach                                 |                +     +              +        +        +           +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +     +              +        +        +           +      |             
      Squamous Cell Papilloma              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +     +                       +        +           +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +     +                       +        +           +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 5| 6| 5| 0| 5| 5| 6| 6| 6| 6| 7| 6| 7| 7| 3| 7| 8| 8| 3| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                A     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +     +                       +        M           +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +     +                       +        +           +      |             
      Follicular Cell, Adenoma             |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                +     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                         +                                                |             
                                            __________________________________________________________________________|             
   Prostate                                |                +     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                            +                                             |             
                                            __________________________________________________________________________|             
   Testes                                  |                +     +                       +        +           +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +     +                       +        +           +      |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Histiocytic                      |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +           +     +  +           +        +     +  +  +  +  +  +     +|             
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |             
           Ear                             |                                                                   X      |             
      Lumbar, Lymphoma Malignant Mixed     | X                                                                        |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                X                                                         |             
      Mandibular, Lymphoma Malignant Mixed |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                X                                                         |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +           +     +                             +  +  +  +  +        +|             
      Lymphoma Malignant Histiocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             | X                                                     X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +              +     +        +              +        +           +  +   |             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Histiocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             | X                                                     X              X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 5| 6| 5| 0| 5| 5| 6| 6| 6| 6| 7| 6| 7| 7| 3| 7| 8| 8| 3| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                A     M                       +        +           M      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                A                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    |    +           A     +                       +        +           +      |             
      Subcutaneous Tissue, Fibroma         |    X                                                                     |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +        +     +  +           +        +     +  +  +  +  +  +  +   |             
      Osteosarcoma                         |                                     X                                    |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +     +                       +        +           +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +     +     +           +           +        +           +      |             
      Alveolar/Bronchiolar Adenoma         |                      X           X           X                           |             
      Alveolar/Bronchiolar Carcinoma       |          X                       X                    X                  |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Carcinoma, Metastatic, Ear           |                                                                   X      |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                      X                                                   |             
      Hepatocholangiocarcinoma, Metastatic |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
                                            __________________________________________________________________________|             
   Nose                                    |                +     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +     +                       +        +           +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                   +      |             
      Basal Cell Carcinoma                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
      Adenoma                              |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +              +     +                       +        +           +  +   |             
      Lymphoma Malignant Histiocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             | X                                                     X              X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +     +                       +        +           +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 5| 6| 5| 0| 5| 5| 6| 6| 6| 6| 7| 6| 7| 7| 3| 7| 8| 8| 3| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             | X                                                     X              X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 9| 4| 7| 4| 4| 4| 9| 4| 4| 4| 4| 4| 3| 4| 4| 4| 5| 4| 4| 0| 4| 3| 4| 4|            |
                                           | 6| 1| 1| 5| 1| 1| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 2| 3| 4| 5| 4| 6| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +           +           +     +           +        +     +      |  14        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +     +           +           +     +           +        +     +      |  11        |
      Lymphoma Malignant Mixed             |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +           +           +     +           +        +     +      |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +           +           +     +           +        +     +      |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +           +           +     +           +        +     +      |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +           +           +     +           +        +     +      |  13        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     A           +           +     +           +        +     +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     A           +           +     +           +        +     +      |  12        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     A           +           +     +           +        +     M      |  11        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     A           +           +     +           +        +     +      |  12        |
      Lymphoma Malignant Mixed             |                                                    X                     |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hemangiosarcoma, Multiple            |                                  X                                       |          2 |
      Hepatocellular Carcinoma             | X        X                 X                                             |         10 |
      Hepatocellular Carcinoma, Multiple   |                               X                          X              X|          4 |
      Hepatocellular Adenoma               |       X                 X        X  X        X     X     X              X|         11 |
      Hepatocellular Adenoma, Multiple     |             X     X  X                    X     X                        |         12 |
      Hepatocholangiocarcinoma             |    X                                                                     |          1 |
      Lymphoma Malignant Histiocytic       |                                                                   X      |          2 |
      Lymphoma Malignant Mixed             |                   X                                         X            |          5 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   2        |
      Hepatocholangiocarcinoma, Metastatic |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +           +           +     +           +        +     +      |  13        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +           +           +     +           +        +     +      |  13        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +           +           +     +     +     +        +     +      |  16        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +           +           +     +     +     +        +     +      |  16        |
      Squamous Cell Papilloma              |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +           +           +     +     +     +        +     +      |  15        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  79                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 9| 4| 7| 4| 4| 4| 9| 4| 4| 4| 4| 4| 3| 4| 4| 4| 5| 4| 4| 0| 4| 3| 4| 4|            |
                                           | 6| 1| 1| 5| 1| 1| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 2| 3| 4| 5| 4| 6| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +           +           +     +           +        +     +      |  14        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +           +           +     +           +        +     +      |  14        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +           +           +     +           +        +     +      |  14        |
      Adenoma                              |                                        X                                 |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +           +           +     +           +        +     +      |  14        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +           +           +     +           +        +     +      |  13        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +     +           +           M     +           +        +     +      |  13        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +     A           +           +     +           +        +     +      |  11        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +           +           +     +           +        +     +      |  14        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +           +           +     +           +        +     +      |  14        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +     +           +           +     +           +        +     +      |  14        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +           +           +     +           +        +     +      |  14        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +           +           +     +           +        +     +      |  14        |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Histiocytic                      |                                                                   X      |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +     +  +  +     +     +     +        +  +     +  +     +  +  +|  30        |
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |            |
           Ear                             |                                                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                                   X      |          2 |
      Mandibular, Lymphoma Malignant Mixed |                   X                                         X            |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                             X            |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                                             X            |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  80                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 9| 4| 7| 4| 4| 4| 9| 4| 4| 4| 4| 4| 3| 4| 4| 4| 5| 4| 4| 0| 4| 3| 4| 4|            |
                                           | 6| 1| 1| 5| 1| 1| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 2| 3| 4| 5| 4| 6| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Lymphoma Malignant Mixed      |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +     +  +  +     +           +        +  +     +  +     +  +   |  22        |
      Lymphoma Malignant Histiocytic       |                                                                   X      |          2 |
      Lymphoma Malignant Mixed             |                   X                                X        X            |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +  +  +  +  +     +     +     +           +        +     +      |  21        |
      Hemangiosarcoma                      |                                  X     X                                 |          2 |
      Lymphoma Malignant Histiocytic       |                                                                   X      |          2 |
      Lymphoma Malignant Mixed             | X           X     X                                         X            |          7 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +     I           +           +     +           M        +     +      |   8        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +     +     +           +     +           +        +     +      |  15        |
      Subcutaneous Tissue, Fibroma         |                      X                                                   |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +     +  +        +     +     +     +     +  +  +  +      |  30        |
      Osteosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                        +                                 |   1        |
      Hemangiosarcoma                      |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +           +           +     +           +        +     +      |  14        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +           +  +        +     +        +  +        +     +      |  19        |
      Alveolar/Bronchiolar Adenoma         | X  X  X              X                          X                        |          8 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          3 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                         X              X                                 |          2 |
      Carcinoma, Metastatic, Ear           |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |          X                                                               |          2 |
      Hepatocholangiocarcinoma, Metastatic |    X                                                                     |          1 |
      Lymphoma Malignant Histiocytic       |                                                                   X      |          1 |
      Lymphoma Malignant Mixed             |                                                             X            |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  81                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 9| 4| 7| 4| 4| 4| 9| 4| 4| 4| 4| 4| 3| 4| 4| 4| 5| 4| 4| 0| 4| 3| 4| 4|            |
                                           | 6| 1| 1| 5| 1| 1| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 2| 3| 4| 5| 4| 6| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +           +           +     +           +        +     +      |  14        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +           +           +     +           +        +     +      |  14        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                       +|   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                       +                  |   2        |
      Adenoma                              |                                                       X                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +           +           +     +           +        +     +      |  16        |
      Lymphoma Malignant Histiocytic       |                                                                   X      |          2 |
      Lymphoma Malignant Mixed             |                                                             X            |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +           +           +     +           +        +     M      |  13        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                   X      |          2 |
      Lymphoma Malignant Mixed             | X           X     X                                X        X            |          8 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                      X                                                   |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  82                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 5| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 8| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3|             
                                           | 4| 5| 4| 4| 4| 5| 5| 3| 5| 5| 6| 6| 4| 6| 6| 6| 6| 7| 4| 7| 7| 6| 7| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    M                 +           +  +     M           +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +        +  +  +        +  +  +  +           +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    A     +           +           +  +     A           +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +           +           +  +  +  +           +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +        +  +  +        +  +     +           +        +     +   |             
      Lymphoma Malignant Mixed             |          X              X                                                |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangiocarcinoma                   |                                                                          |             
      Hepatoblastoma, Multiple             |                                                                          |             
      Hepatocellular Carcinoma             |    X                 X           X        X           X                  |             
      Hepatocellular Carcinoma, Multiple   |                                                                      X   |             
      Hepatocellular Adenoma               | X        X                          X                                    |             
      Hepatocellular Adenoma, Multiple     |                   X  X  X  X                                             |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                    +                  |             
      Sarcoma                              |                                                       X                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |    A                 +           +  +     +           +        +     +   |             
      Sarcoma, Metastatic, Mesentery       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                  +  +     +                          +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +                 +           +  +     +           +        +     +   |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                      X                                                   |             
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    M                 I           +  I     M           M        M     I   |             
      Pars Distalis, Carcinoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 5| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 8| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3|             
                                           | 4| 5| 4| 4| 4| 5| 5| 3| 5| 5| 6| 6| 4| 6| 6| 6| 6| 7| 4| 7| 7| 6| 7| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    A                 +           +  +     +           +        +     +   |             
      Follicular Cell, Adenoma             |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                            +                                             |             
                                            __________________________________________________________________________|             
   Prostate                                |    +                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                         +|             
                                            __________________________________________________________________________|             
   Testes                                  |    +                 +           +  +     +           +        +     +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    A     +        +  +  +  +  +  +  +  +  +           +  +  +  +  +  +  +|             
      Mediastinal, Cholangiocarcinoma,     |                                                                          |             
           Metastatic, Liver               |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +        +  +  +     +        +                 +  +     +  +  +|             
      Lymphoma Malignant Mixed             |          X                    X                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    A  +  +           +           +  +     +  +        +  +     +     +   |             
      Lymphoma Malignant Mixed             |       X  X                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  |    M                 +           M  +     +           +        +     +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +                 +           +  +     +           +        +     +   |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +        +  +  +     +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
      Hemangiosarcoma                      |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +                 +           +  +     +           +        +     +   |             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +                 +     +     +  +  +  +           +  +  +  +     +   |             
      Alveolar/Bronchiolar Adenoma         |                      X     X                          X  X  X            |             
      Alveolar/Bronchiolar Carcinoma       |                      X                                                   |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 5| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 8| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3|             
                                           | 4| 5| 4| 4| 4| 5| 5| 3| 5| 5| 6| 6| 4| 6| 6| 6| 6| 7| 4| 7| 7| 6| 7| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Multiple                         |                                        X                                 |             
      Cholangiocarcinoma, Metastatic, Liver|                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |    X                                                                 X   |             
                                            __________________________________________________________________________|             
   Nose                                    |    +                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +                 +           +  +     +           +        +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    A        +        +           +  +     +           +        +     +   |             
      Sarcoma, Metastatic, Mesentery       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +                 +           +  +     +           +        +     +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |       X  X              X     X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4|            |
                                           | 4| 8| 8| 1| 1| 1| 1| 2| 2| 2| 2| 3| 2| 3| 3| 3| 4| 8| 4| 4| 4| 9| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                   +              +           +         |  12        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +                                   +              M           A         |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +                 +                 +              +           +         |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                 +                 +              A           +         |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                   +              +           +         |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                   +              +           +         |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +              +              +        +     A           +         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                   +              A           A         |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                   +              A           +         |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +              +              +        +     A           +         |  17        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cholangiocarcinoma                   |                                                    X                     |          1 |
      Hepatoblastoma, Multiple             |                                  X                                       |          1 |
      Hepatocellular Carcinoma             |                      X        X  X     X        X                    X   |         11 |
      Hepatocellular Carcinoma, Multiple   |    X                                                                     |          2 |
      Hepatocellular Adenoma               |       X                    X     X     X  X                    X  X      |         10 |
      Hepatocellular Adenoma, Multiple     |                   X                             X                        |          6 |
      Lymphoma Malignant Histiocytic       |                                                                X         |          1 |
      Lymphoma Malignant Mixed             |                                        X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                   +        +     A           +         |  11        |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                   +              +           +         |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +                    +     +        +              A           +         |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                    +     +        +              A                     |  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                   +              A                     |   9        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                     +                                    |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                   +              +           +         |  12        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Cholangiocarcinoma, Metastatic, Liver|                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +                                   +              +           +         |  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +                                   +              +           +         |  11        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  86                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4|            |
                                           | 4| 8| 8| 1| 1| 1| 1| 2| 2| 2| 2| 3| 2| 3| 3| 3| 4| 8| 4| 4| 4| 9| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +                                   +              +           +         |  11        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                   +              A           +         |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                   +              +           +         |  11        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                   +              I           +         |   4        |
      Pars Distalis, Carcinoma             |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                   +              +           +         |  11        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +                                   +              +           +         |  12        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +           +        +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +                                   +              +           +         |  12        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +                                   +              +           +         |  12        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                   +              +           +         |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +              +  +  +  +  +        +  +        +  +     +|  32        |
      Mediastinal, Cholangiocarcinoma,     |                                                                          |            |
           Metastatic, Liver               |                                                    X                     |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +           +              +  +     +  +           +           +     +|  20        |
      Lymphoma Malignant Mixed             |                                        X                                 |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                             +     +  +  +        A           +  +      |  18        |
      Lymphoma Malignant Mixed             |                                        X                                 |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M                                   M              +           M         |   7        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                    +              +              +           +         |  13        |
      Subcutaneous Tissue, Lipoma          |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +     +  +     +     +  +  +     +  +  +  +   |  40        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Hemangiosarcoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  87                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4|            |
                                           | 4| 8| 8| 1| 1| 1| 1| 2| 2| 2| 2| 3| 2| 3| 3| 3| 4| 8| 4| 4| 4| 9| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                   +              +           +         |  12        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                X         |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                             +     +              +           +     +  +|  19        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          5 |
      Alveolar/Bronchiolar Carcinoma       |                                                                         X|          2 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         | X                                                                        |          2 |
      Cholangiocarcinoma, Metastatic, Liver|                                                    X                     |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                               X                                          |          3 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                   +              +           +         |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                   +              +           +         |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +                                                                  |   2        |
      Adenocarcinoma                       |       X                                                                  |          1 |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                   +              +           +         |  12        |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                   +              +           +         |  12        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                X         |          1 |
      Lymphoma Malignant Mixed             |                                        X                                 |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  88                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 8| 2| 3| 3| 3| 1|             
                                           | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 2| 6| 6| 6| 8| 7| 7| 7| 5| 9| 7| 8| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |             +           +        A           +           +              +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +           +        A           +           +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +           +        A           +           +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +           +        A           +           +              +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +           +        A           +           +              +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hemangiosarcoma, Multiple            | X                                                                        |             
      Hepatocellular Carcinoma             |       X                    X     X           X                          X|             
      Hepatocellular Carcinoma, Multiple   | X                       X              X                                 |             
      Hepatocellular Adenoma               |    X  X        X  X                          X        X              X   |             
      Hepatocellular Adenoma, Multiple     |                      X  X  X  X                    X           X         |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +           +        A           +           +              +|             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +           +        +           +           +              +|             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +  +  +  +  +        A           +           +           +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +  +  +  +  +        A           +           +           +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +     +  +  +        A           +           +           +  +|             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +           +        +           +           +              +|             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +           +        A           +           +              +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +           +        A           +           +              +|             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +           +        A           +           +              +|             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +           +        A           +           +              +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +           +        +           +           +              +|             
      Pars Intermedia, Carcinoma           |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 8| 2| 3| 3| 3| 1|             
                                           | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 2| 6| 6| 6| 8| 7| 7| 7| 5| 9| 7| 8| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +           +        +           +           +              +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |             +           +        +           +           +              +|             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Testes                                  |             +           +        +           +           +              +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +           +        +           +           +              +|             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Histiocytic                      |                                                                          |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +  +  +     +        +  +        +     +  +  +     +        +|             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |             X                                                            |             
      Mandibular, Lymphoma Malignant Mixed |                                                                          |             
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |             X                                                            |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|             X                                                            |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +        +  +  +  +                 +                 +        +         |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +     +           +     +  A  +        +           +              +|             
      Hemangiosarcoma                      |                               X                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +           M        M           +           +              M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 8| 2| 3| 3| 3| 1|             
                                           | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 2| 6| 6| 6| 8| 7| 7| 7| 5| 9| 7| 8| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |             +           +        +           +           +           +  +|             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +  +     +  +  +     +  +  +  +  +  +     +     +           +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +           +        +           +           +              +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                          X               |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +           +           +        +  +  +     +           +              +|             
      Alveolar/Bronchiolar Adenoma         |                                     X                                    |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           | X                                      X     X                           |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Trachea                                 |             +           +        +           +           +              +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +           +        A           +           +              +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +           +        +           +           +              +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 8| 2| 3| 3| 3| 1|             
                                           | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 2| 6| 6| 6| 8| 7| 7| 7| 5| 9| 7| 8| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 6| 4| 4| 7| 3| 4| 8| 4| 4| 4| 4|            |
                                           | 8| 8| 3| 4| 1| 1| 1| 1| 2| 2| 0| 2| 2| 3| 0| 3| 3| 4| 2| 3| 8| 4| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +                    +           +        +  +     +            |  13        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       A  +                    +           +        +  +     +            |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +  +                    +           +        +  +     +            |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       A  +                    +           +        +  +     +            |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +                    +           +        +  +     +            |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       A  +                    +           +        +  +     +            |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       A  +                    +           +        A  +     +           +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       A  +                    +           +        A  +     +            |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       A  +                    +           +        A  +     +           +|  11        |
      Lymphoma Malignant Mixed             |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       A  +                    +           +        A  +     +            |  10        |
      Lymphoma Malignant Histiocytic       |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma, Multiple            |       X                       X                             X            |          4 |
      Hepatocellular Carcinoma             | X           X  X                 X                    X                 X|         11 |
      Hepatocellular Carcinoma, Multiple   |    X                                   X           X        X            |          7 |
      Hepatocellular Adenoma               | X                             X                                      X   |         10 |
      Hepatocellular Adenoma, Multiple     |                   X  X  X  X     X                       X     X         |         13 |
      Lymphoma Malignant Histiocytic       |                               X                       X                  |          2 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +                    +           +        +  +     +  +         |  13        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +                    +           +        +  +     +            |  13        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +  +  +                 +           +  +     +  +     +            |  18        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +  +                 +           +  +     +  +     +            |  18        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +  +                 +           +        +  +     +            |  16        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +                    +           +        +  +     +            |  13        |
      Hemangiosarcoma                      |       X                       X                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +  +                    +           +        +  +     +            |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +  +                    +           +        +  +     +            |  12        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +  +                    +           M        +  +     +            |  11        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  93                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 6| 4| 4| 7| 3| 4| 8| 4| 4| 4| 4|            |
                                           | 8| 8| 3| 4| 1| 1| 1| 1| 2| 2| 0| 2| 2| 3| 0| 3| 3| 4| 2| 3| 8| 4| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +                    +           +        +  +     +            |  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +  +                    +           +        +  +     +            |  13        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +                    +           M        I  I     +            |  10        |
      Pars Intermedia, Carcinoma           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +                    +           +        +  +     +            |  13        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +  +                    +           +        +  +     +            |  13        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                     +     +                              |   2        |
                                            __________________________________________________________________________|____________|
   Prostate                                |       +  +                    +           +        +  +     +            |  13        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  |       +  +                    +           +        +  +     +            |  13        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +                    +           +        +  +     +            |  13        |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Histiocytic                      |                               X                       X                  |          2 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +              +     +           +  +     +  +  +  +  +        +|  27        |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                               X                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mandibular, Lymphoma Malignant Mixed |                                                                         X|          1 |
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      | X                                                                        |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                               X                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                         X|          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                         X|          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                         X|          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  94                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 6| 4| 4| 7| 3| 4| 8| 4| 4| 4| 4|            |
                                           | 8| 8| 3| 4| 1| 1| 1| 1| 2| 2| 0| 2| 2| 3| 0| 3| 3| 4| 2| 3| 8| 4| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                         +     +           +  +     +        +  +        +|  16        |
      Lymphoma Malignant Histiocytic       |                               X                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                         X                                               X|          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +              +  +  +  +        +        +  +     +           +|  20        |
      Hemangiosarcoma                      |       X                                                     X            |          3 |
      Lymphoma Malignant Histiocytic       |                               X                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
      Lymphoma Malignant Mixed             |                         X  X                                            X|          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       M  M                    M           +        +  +     +            |   7        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +                    +           +        +  +     +            |  14        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                           X                              |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +                    +     +  +  +  +     +  +     +  +        +|  30        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +                    +           +        +  +     +            |  13        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +     +     +        +           +     +  +  +  +  +            |  21        |
      Alveolar/Bronchiolar Adenoma         | X        X                                      X        X               |          5 |
      Alveolar/Bronchiolar Carcinoma       | X              X                                X                        |          3 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                      X                                                   |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           | X              X                                                         |          5 |
      Lymphoma Malignant Histiocytic       |                               X                       X                  |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +                    +           +        +  +     +            |  13        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +                    +           +        +  +     +            |  13        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  95                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 6| 4| 4| 7| 3| 4| 8| 4| 4| 4| 4|            |
                                           | 8| 8| 3| 4| 1| 1| 1| 1| 2| 2| 0| 2| 2| 3| 0| 3| 3| 4| 2| 3| 8| 4| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                          +           +   |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                          +           +   |   2        |
      Adenoma                              |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +                    +           +        +  +     +            |  13        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           | X                                                                        |          1 |
      Lymphoma Malignant Histiocytic       |                               X                       X                  |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +                    +           +        +  +     +            |  13        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                               X                       X                  |          2 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
      Lymphoma Malignant Mixed             |                         X  X                                            X|          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  96                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8| 3| 3| 4| 3| 3| 3| 3| 1| 2| 3| 3| 3| 8|             
                                           | 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 0| 6| 6| 3| 6| 7| 7| 7| 3| 0| 7| 8| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +                 M              I        +              A  M        +  M|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | M                 A              +        +              +  +        +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +                 +              +        +              +  +        +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Multiple            |                                                                          |             
      Hepatoblastoma                       |                                                                          |             
      Hepatocellular Carcinoma             |       X                 X  X           X                 X  X           X|             
      Hepatocellular Carcinoma, Multiple   |                                                                   X      |             
      Hepatocellular Adenoma               |       X     X  X                          X                       X  X   |             
      Hepatocellular Adenoma, Multiple     |                   X     X                    X                           |             
      Lymphoma Malignant Histiocytic       |                                  X     X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                    +               |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +                 +              +        +              +  +        +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +                 +              +  +     +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +                                +  +     +                 +        +  +|             
      Squamous Cell Papilloma              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +                                +        +                 +        +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                           +                              |             
      Squamous Cell Carcinoma              |                                           X                              |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +                 +              +        +              +  +        +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +                 +              +        +              +  +        +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8| 3| 3| 4| 3| 3| 3| 3| 1| 2| 3| 3| 3| 8|             
                                           | 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 0| 6| 6| 3| 6| 7| 7| 7| 3| 0| 7| 8| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +                 +              +        +              I  +        +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +                 +              +        +              +  +        +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +                                                               |             
                                            __________________________________________________________________________|             
   Prostate                                | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +                 +              +        +              +  +        +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +                 +              +        +              +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | M  +  +        +  +           +  +     +  +              +  +  +  +  +  +|             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                X         |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                X         |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                X         |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                X         |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                X         |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +        +              +        +                 +     +  +      |             
      Lymphoma Malignant Histiocytic       |                                        X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +              +  +           +     +  +              +  +  +     +  +|             
      Lymphoma Malignant Histiocytic       |                                        X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | M                 +              I        +              +  M        +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8| 3| 3| 4| 3| 3| 3| 3| 1| 2| 3| 3| 3| 8|             
                                           | 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 0| 6| 6| 3| 6| 7| 7| 7| 3| 0| 7| 8| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +              +              +        +              +  +  +     +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Subcutaneous Tissue, Fibrosarcoma    |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +           +     +     +  +        +  +  +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                 +              +     +  +              +  +        +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +                 +           +  +        +  +        +  +  +        +  +|             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                   X                                                      |             
      Alveolar/Bronchiolar Adenoma         |                                              X                           |             
      Alveolar/Bronchiolar Carcinoma       |                               X                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                       X                  |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                         X|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +                 +              +        +              +  +        +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                             +                        |             
      Adenocarcinoma                       |                   X                                                      |             
      Adenoma                              |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +                 +              +        +              +  +        +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +        +              +        +              +  +        +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                  X     X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                      X                                            X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 5| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 6| 2| 4| 4| 7| 4| 6| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 3| 6| 6| 4|            |
                                           | 8| 8| 8| 1| 6| 3| 9| 1| 3| 1| 0| 1| 2| 2| 2| 2| 3| 7| 3| 3| 3| 2| 0| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |             +     +     +  +  +                    M           +  +  M   |  10        |
      Lymphoma Malignant Mixed             |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                   +     +  +  +                    +           +  +  +   |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                   +     +  +  +                    M           +  +  +   |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                   +     +  +  +                    +           +  +  +   |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                   A     +  +  +                    +           +  +  +   |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                   +     +  +  +                    +           +  +  +   |  14        |
      Lymphoma Malignant Mixed             |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                   +     +  +  +                    +           +  +  +   |  16        |
      Lymphoma Malignant Mixed             |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma, Multiple            |                                        X                                 |          1 |
      Hepatoblastoma                       |                                                    X                     |          1 |
      Hepatocellular Carcinoma             | X     X                       X                    X     X        X  X   |         14 |
      Hepatocellular Carcinoma, Multiple   |             X        X  X                                                |          4 |
      Hepatocellular Adenoma               |                               X  X  X  X     X     X  X     X        X   |         15 |
      Hepatocellular Adenoma, Multiple     |                      X                                                  X|          5 |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                            X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   3        |
      Lymphoma Malignant Mixed             |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +     +     +  +  +                    +           +  +  +   |  17        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Mixed             |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |             +     +     +  +  +                 +  +           +  +  +   |  19        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                         +  +  +                 +  +           +  +  +   |  15        |
      Squamous Cell Papilloma              |                                                 X                        |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                         +  +  +                    +           +  +  +   |  13        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                   +                                +                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +     +     +  +  +                    +           +  +  +   |  17        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 100                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 5| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 6| 2| 4| 4| 7| 4| 6| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 3| 6| 6| 4|            |
                                           | 8| 8| 8| 1| 6| 3| 9| 1| 3| 1| 0| 1| 2| 2| 2| 2| 3| 7| 3| 3| 3| 2| 0| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |             M     +     +  +  +                    +           +  +  M   |  14        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |             +     +     +  +  +                    +           +  +  +   |  17        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +                          +                                    |   3        |
                                            __________________________________________________________________________|____________|
   Prostate                                |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +                                                        +      |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  |             +     +     +  +  +                    +           +  +  +   |  17        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +     +     +  +  +                    +           +  +  +   |  18        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +        +  +  +  +     +  +  +        +        +  +  +  +     +  +  +  +|  31        |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                X         |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                            X                                   X         |          2 |
      Renal, Lymphoma Malignant Histiocytic|                   X                                                      |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                        +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +        +     +  +        +           +        +  +  +  +     +     +  +|  20        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 101                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 5| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 6| 2| 4| 4| 7| 4| 6| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 3| 6| 6| 4|            |
                                           | 8| 8| 8| 1| 6| 3| 9| 1| 3| 1| 0| 1| 2| 2| 2| 2| 3| 7| 3| 3| 3| 2| 0| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                   X                             X                        |          3 |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          2 |
      Lymphoma Malignant Mixed             |                            X                                   X        X|          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |             +     +     +  +  +        +           +  +  +     +  +  +  +|  25        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                            X                                   X        X|          4 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |             +     +     M  M  +                    +           +  M  +   |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +     +     +     +  +  +                    +           +  +  +   |  20        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  37        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +     +     +  +  +                    +           +  +  +   |  18        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |             +     +     +  +  +                    +           +  +  +   |  20        |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Harderian Gland                  |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                   X           X                                          |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                         X                                         X  X   |          4 |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Mixed             |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +     +     +  +  +                    +           +  +  +   |  17        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                              +                           |   3        |
      Adenocarcinoma                       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 102                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 5| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 6| 2| 4| 4| 7| 4| 6| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 3| 6| 6| 4|            |
                                           | 8| 8| 8| 1| 6| 3| 9| 1| 3| 1| 0| 1| 2| 2| 2| 2| 3| 7| 3| 3| 3| 2| 0| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                              X                           |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +        +     +     +  +  +                    +           +  +  +   |  18        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Mixed             |                            X                                             |          1 |
      Renal Tubule, Carcinoma              |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +     +     +  +  +                    +           +  +  +   |  18        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                   X                             X                        |          4 |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          2 |
      Lymphoma Malignant Mixed             |                            X                                   X        X|          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 103                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 2| 8| 3| 3|             
                                           | 4| 4| 4| 4| 2| 5| 5| 5| 9| 5| 6| 6| 2| 6| 6| 7| 7| 0| 7| 7| 8| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +           +           +              +              +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             |             +           M           A              M              +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +        +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +        +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +     +     +           A        +     +              +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +           +           A              A              +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +     +     +           A        +     +              +      |             
      Lymphoma Malignant Mixed             |                                              X                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Multiple            |                         X                                                |             
      Hepatoblastoma                       |                                                                          |             
      Hepatocellular Carcinoma             |                               X  X                 X     X           X   |             
      Hepatocellular Carcinoma, Multiple   |                                                                         X|             
      Hepatocellular Adenoma               | X     X  X                                      X        X        X  X   |             
      Hepatocellular Adenoma, Multiple     |    X           X        X        X                          X            |             
      Lymphoma Malignant Histiocytic       |                                     X                                    |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +           +           A     +        +              +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +           +           A     +        +              +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +           +           A     +        +              +      |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +           +           +              +              +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             M           M           +              +              +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +           M           A              +              +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +           +           +              +              +      |             
      Follicular Cell, Adenoma             |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 2| 8| 3| 3|             
                                           | 4| 4| 4| 4| 2| 5| 5| 5| 9| 5| 6| 6| 2| 6| 6| 7| 7| 0| 7| 7| 8| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                      +                    +           +     +            |             
      Hemangiosarcoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                             +            |             
                                            __________________________________________________________________________|             
   Testes                                  |             +           +           A              +              +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           M  +        +        +  A     +        +  +     +     +     +|             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +              +        +        +                                      +|             
      Hemangiosarcoma                      |                         X                                                |             
      Lymphoma Malignant Mixed             | X                                                                       X|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +        +     +  +  +           A  +     +  +  +              +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                         X                           |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +           +           A              M              +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |             +           +           +              +              +      |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +  +  +  +     +     +     +  +     +     +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +           +           +              +              +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +           +  +     +  +     +     +  +           +  +           +     +|             
      Alveolar/Bronchiolar Adenoma         | X                                                                        |             
      Alveolar/Bronchiolar Carcinoma       |                X              X                                         X|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                      X                                X                  |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                         X|             
      Lymphoma Malignant Histiocytic       |                                     X                                    |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                   X      |             
                                            __________________________________________________________________________|             
   Nose                                    |             +           +           +              +              +      |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +           +           +              +              +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 2| 8| 3| 3|             
                                           | 4| 4| 4| 4| 2| 5| 5| 5| 9| 5| 6| 6| 2| 6| 6| 7| 7| 0| 7| 7| 8| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +        +                       +                                       |             
      Adenoma                              | X        X                       X                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +           +           A              +              +      |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                   X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +           +           A              +              +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Histiocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             | X  X                                         X                          X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 4| 4| 3| 7| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9|            |
                                           | 8| 1| 1| 3| 8| 1| 3| 1| 2| 2| 2| 2| 3| 3| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  +     +                       +                             +|  10        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          M  A     +                       +                             +|   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +  A     +                       +                             +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +  A                             +                             +|   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  A                             +                             +|   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +  A                             +                             +|   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +  A     +                       +     +                       +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +  A                             +     +                       +|   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +  A                             M                             +|   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  A                             A                             +|   8        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma                      |                                     X                                    |          1 |
      Hemangiosarcoma, Multiple            |                                                                          |          1 |
      Hepatoblastoma                       |                                     X                                    |          1 |
      Hepatocellular Carcinoma             | X     X                                   X     X  X     X               |         11 |
      Hepatocellular Carcinoma, Multiple   |                                                       X                 X|          3 |
      Hepatocellular Adenoma               |                               X     X                          X  X      |         11 |
      Hepatocellular Adenoma, Multiple     |                                  X        X                          X   |          8 |
      Lymphoma Malignant Histiocytic       |          X                                                               |          2 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +  A     +                       +                             +|   8        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +     +                       +                             +|   9        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +  +     +                       +                             +|  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +  +                             +                             +|   9        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +  +                             +                             +|   9        |
      Adenoma                              |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |          +                                +                              |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +     +                       +                             +|  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |          +  +     +                       +                             +|   9        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +  +     +                       +                             +|   9        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +  +     +                       +                             +|   9        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +  A     +                       +                             +|   8        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +  +     +                       +                             +|   8        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 107                                                               
NTP Experiment-Test: 05075-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 14:35:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 4| 4| 3| 7| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9|            |
                                           | 8| 1| 1| 3| 8| 1| 3| 1| 2| 2| 2| 2| 3| 3| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +  +     +                       +                             M|   7        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +  A     +                       +                             +|   9        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +  +     +                       +                             +|   9        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                               +           +                    +        +|   8        |
      Hemangiosarcoma                      |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                |          +  +     +                       +                             +|   9        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  |          +  +     +                       +                             +|   9        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +     +                       +                             +|   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +  +  +                       +     +     +  +  +  +        +|  23        |
      Mediastinal, Lymphoma Malignant Mixed|    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +           +                          +     +     +  +  +  +        +|  15        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +  A     +  +                 +  +                 +           +|  17        |
      Lymphoma Malignant Histiocytic       |          X                                                               |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |          M  +     +                       +                             +|   7        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +  +     +                       M                             +|   9        |
      Subcutaneous Tissue, Fibrosarcoma    |             X