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TDMS Study 05075-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         DIPHENYLHYDANTOIN


NTP Experiment-Test: 05075-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/09/94
Route: DOSED FEED                                                                                                 Time: 15:42:01




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57-41-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        60 PPM       200 PPM      200 PPM      200 PPM         
                                                    0-0          10-0         1-1          10-3         3-3          0-3            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Natural Death                                      6            5            6            7            6            4           
    Moribund Sacrifice                                 8           11            9            6            6            8           
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           34           35           37           38           38           
  Animals Examined Microscopically                    50           50           50           50           50           50           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (14)         (14)         (12)         (11)         (11)         
   Intestine Large, Cecum                             (46)         (15)         (20)         (13)         (10)         (11)         
      Leiomyosarcoma                                                                          1 (8%)                                
   Intestine Large, Colon                             (48)         (16)         (15)         (13)         (12)         (11)         
      Leiomyoma                                        1 (2%)                                                                       
      Leiomyosarcoma                                                                                       1 (8%)                   
   Intestine Small, Ileum                             (46)         (15)         (14)         (14)         (11)         (11)         
   Intestine Small, Jejunum                           (48)         (16)         (14)         (15)         (12)         (11)         
      Adenocarcinoma                                                                                       1 (8%)                   
   Liver                                              (48)         (49)         (50)         (50)         (50)         (49)         
      Hemangiosarcoma                                               2 (4%)       2 (4%)                                             
      Hemangiosarcoma, Multiple                                     1 (2%)                                                          
      Hepatocellular Carcinoma                                      1 (2%)       4 (8%)       4 (8%)       3 (6%)       1 (2%)      
      Hepatocellular Adenoma                           5 (10%)      8 (16%)     10 (20%)      7 (14%)     20 (40%)      8 (16%)     
      Hepatocellular Adenoma, Multiple                              3 (6%)       1 (2%)       5 (10%)      5 (10%)      5 (10%)     
   Mesentery                                          (8)          (2)          (5)          (4)          (4)          (2)          
   Pancreas                                           (47)         (15)         (15)         (12)         (12)         (11)         
   Salivary Glands                                    (49)         (15)         (14)         (14)         (12)         (11)         
   Stomach, Forestomach                               (48)         (20)         (20)         (20)         (12)         (16)         
      Squamous Cell Papilloma                          2 (4%)       3 (15%)      3 (15%)      2 (10%)                               
      Squamous Cell Papilloma, Multiple                                                       1 (5%)                                
   Stomach, Glandular                                 (48)         (16)         (16)         (15)         (11)         (13)         
   Tongue                                                                       (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
   Tooth                                              (5)                                    (1)                       (1)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (16)         (15)         (13)         (12)         (13)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        60 PPM       200 PPM      200 PPM      200 PPM         
                                                    0-0          10-0         1-1          10-3         3-3          0-3            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)         (16)         (14)         (13)         (12)         (11)         
   Adrenal Gland, Medulla                             (48)         (16)         (14)         (13)         (12)         (11)         
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Complex                         1 (2%)                                                                       
      Pheochromocytoma Benign                          2 (4%)       2 (13%)      1 (7%)       1 (8%)                                
   Islets, Pancreatic                                 (47)         (15)         (14)         (12)         (11)         (11)         
   Pituitary Gland                                    (44)         (19)         (17)         (17)         (14)         (15)         
      Pars Distalis, Adenoma                           6 (14%)      8 (42%)      3 (18%)      2 (12%)      3 (21%)      8 (53%)     
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Intermedia, Adenoma                                      1 (5%)                                                          
   Thyroid Gland                                      (47)         (16)         (15)         (14)         (12)         (11)         
      C-Cell, Carcinoma                                                                       1 (7%)                                
      Follicular Cell, Adenoma                         4 (9%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (28)         (36)         (28)         (25)         (30)         
      Choriocarcinoma                                               1 (4%)                                                          
      Cystadenoma                                      1 (2%)                    1 (3%)       3 (11%)      1 (4%)       1 (3%)      
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Hemangioma                                                                              1 (4%)                                
      Luteoma                                          1 (2%)                                                                       
      Periovarian Tissue, Hemangiosarcoma              1 (2%)                                                                       
   Uterus                                             (49)         (36)         (31)         (33)         (33)         (32)         
      Hemangiosarcoma                                               1 (3%)                                                          
      Polyp Stromal                                    1 (2%)                                              1 (3%)                   
      Sarcoma Stromal                                               1 (3%)                                              2 (6%)      
      Sarcoma Stromal, Multiple                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)                                                                           
   Bone Marrow                                        (48)         (16)         (15)         (13)         (12)         (11)         
      Femoral, Hemangiosarcoma                         1 (2%)       2 (13%)                                                         
   Lymph Node                                         (50)         (18)         (16)         (20)         (15)         (20)         
      Mandibular, Adenocarcinoma, Metastatic,                                                                                       
          Harderian Gland                                                                                               1 (5%)      
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                                                             1 (5%)      
                                                             Page   3                                                               
NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        60 PPM       200 PPM      200 PPM      200 PPM         
                                                    0-0          10-0         1-1          10-3         3-3          0-3            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Mediastinal, Osteosarcoma, Metastatic,                                                                                        
          Uncertain Primary Site                                                                                        1 (5%)      
      Mediastinal, Mandibular, Sarcoma, Metastatic,                                                                                 
           Eye                                                                   1 (6%)                                             
   Lymph Node, Mesenteric                             (12)         (7)          (5)          (6)          (4)          (9)          
      Hemangiosarcoma                                               1 (14%)                                                         
   Spleen                                             (48)         (23)         (27)         (23)         (23)         (27)         
      Hemangiosarcoma                                  3 (6%)       4 (17%)                                                         
   Thymus                                             (42)         (12)         (11)         (9)          (11)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (46)         (15)         (12)         (13)         (9)          (5)          
      Adenocarcinoma                                   1 (2%)       1 (7%)       2 (17%)      2 (15%)                               
   Skin                                               (49)         (16)         (17)         (13)         (12)         (13)         
      Squamous Cell Carcinoma                                                                                           1 (8%)      
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (6%)       1 (6%)                    1 (8%)       1 (8%)      
      Subcutaneous Tissue, Hemangiosarcoma                          3 (19%)                                                         
      Subcutaneous Tissue, Myxoma                      1 (2%)                                                                       
      Subcutaneous Tissue, Myxosarcoma                                           1 (6%)                                             
      Subcutaneous Tissue, Sarcoma                                  1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (16)         (16)         (13)         (12)         (12)         
      Femur, Osteoma                                                             1 (6%)                                             
   Skeletal Muscle                                    (1)          (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (16)         (15)         (13)         (13)         (12)         
      Adenocarcinoma, Metastatic, Harderian Gland                                                          1 (8%)                   
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
   Spinal Cord                                        (1)          (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (20)         (20)         (15)         (13)         (13)         
      Adenocarcinoma, Metastatic, Harderian Gland                   1 (5%)                                              1 (8%)      
      Alveolar/Bronchiolar Adenoma                     5 (10%)      2 (10%)      1 (5%)       2 (13%)                   2 (15%)     
      Alveolar/Bronchiolar Carcinoma                                1 (5%)       1 (5%)       1 (7%)       1 (8%)       1 (8%)      
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (5%)       2 (10%)                                1 (8%)      
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
                                                             Page   4                                                               
NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        60 PPM       200 PPM      200 PPM      200 PPM         
                                                    0-0          10-0         1-1          10-3         3-3          0-3            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
          Site                                                                   1 (5%)                                 1 (8%)      
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                1 (2%)                                                                       
      Sarcoma, Metastatic, Eye                                                   1 (5%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                                                             1 (8%)      
   Nose                                               (50)         (16)         (15)         (13)         (12)         (12)         
      Adenocarcinoma, Metastatic, Harderian Gland                   1 (6%)                                              1 (8%)      
      Sarcoma, Metastatic, Eye                                                   1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (2)          (1)          (2)          (1)          (3)          
      Adenocarcinoma, Metastatic, Harderian Gland                                                                       1 (33%)     
      Sarcoma                                                                    1 (100%)                                           
   Harderian Gland                                    (8)          (4)          (4)          (3)          (4)          (4)          
      Adenocarcinoma                                   1 (13%)      3 (75%)                   1 (33%)      1 (25%)      2 (50%)     
      Adenoma                                          3 (38%)      1 (25%)      2 (50%)      1 (33%)      3 (75%)      2 (50%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (48)         (16)         (16)         (13)         (14)         (12)         
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                                                          1 (8%)      
   Urinary Bladder                                    (48)         (15)         (15)         (13)         (11)         (11)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)        *(50)        *(50)         
      Lymphoma Malignant Histiocytic                   5 (10%)      3 (6%)       6 (12%)      4 (8%)       2 (4%)                   
      Lymphoma Malignant Lymphocytic                   9 (18%)      2 (4%)                                 2 (4%)       1 (2%)      
      Lymphoma Malignant Mixed                         9 (18%)      8 (16%)      3 (6%)      11 (22%)     10 (20%)     12 (24%)     
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        60 PPM       200 PPM      200 PPM      200 PPM         
                                                    0-0          10-0         1-1          10-3         3-3          0-3            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          36          27          36          39          36               
     Total Primary Neoplasms                           69          65          47          50          55          47               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 23          22          18          22          29          24               
     Total Benign Neoplasms                            33          28          23          25          33          26               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              29          28          21          23          21          20               
     Total Malignant Neoplasms                         36          37          24          25          22          21               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2           4                       1           4               
     Total Metastatic Neoplasm                          2           3           6                       1          10               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                   1               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        600 PPM      600 PPM                                                             
                                                    10-10        0-10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Natural Death                                      4            5                                                               
    Moribund Sacrifice                                 6            8                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           37                                                               
  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (45)                                                             
   Intestine Large, Rectum                            (50)         (47)                                                             
   Intestine Small, Duodenum                          (49)         (48)                                                             
   Intestine Small, Jejunum                           (48)         (48)                                                             
   Liver                                              (50)         (50)                                                             
      Hepatoblastoma                                                1 (2%)                                                          
      Hepatocellular Carcinoma                        10 (20%)      9 (18%)                                                         
      Hepatocellular Carcinoma, Multiple                            2 (4%)                                                          
      Hepatocellular Adenoma                          19 (38%)     16 (32%)                                                         
      Hepatocellular Adenoma, Multiple                 7 (14%)      6 (12%)                                                         
   Mesentery                                          (6)          (6)                                                              
   Pancreas                                           (49)         (48)                                                             
   Salivary Glands                                    (50)         (49)                                                             
   Stomach, Forestomach                               (49)         (48)                                                             
      Mast Cell Tumor NOS                              1 (2%)                                                                       
   Stomach, Glandular                                 (49)         (48)                                                             
      Mast Cell Tumor NOS                              1 (2%)                                                                       
   Tooth                                              (12)         (9)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (48)                                                             
   Adrenal Gland, Medulla                             (50)         (48)                                                             
      Pheochromocytoma Malignant                                    1 (2%)                                                          
      Pheochromocytoma Benign                          2 (4%)                                                                       
   Pituitary Gland                                    (44)         (41)                                                             
      Pars Distalis, Adenoma                           3 (7%)       3 (7%)                                                          
                                                             Page   7                                                               
NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        600 PPM      600 PPM                                                             
                                                    10-10        0-10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Thyroid Gland                                      (49)         (50)                                                             
      Follicular Cell, Adenoma                         4 (8%)       2 (4%)                                                          
      Follicular Cell, Adenoma, Multiple                            2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (49)                                                             
      Cystadenoma                                      1 (2%)       2 (4%)                                                          
      Luteoma                                                       1 (2%)                                                          
      Teratoma                                         1 (2%)                                                                       
   Uterus                                             (50)         (50)                                                             
      Adenocarcinoma                                                1 (2%)                                                          
      Polyp Stromal                                    1 (2%)                                                                       
   Vagina                                                          (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (3)          (1)                                                              
   Bone Marrow                                        (49)         (50)                                                             
   Lymph Node                                         (48)         (49)                                                             
   Lymph Node, Mesenteric                             (6)          (6)                                                              
   Spleen                                             (50)         (48)                                                             
   Thymus                                             (42)         (45)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (39)         (40)                                                             
   Skin                                               (49)         (50)                                                             
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        600 PPM      600 PPM                                                             
                                                    10-10        0-10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)                                                             
      Alveolar/Bronchiolar Adenoma                     1 (2%)       2 (4%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       2 (4%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
      Mediastinum, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                         1 (2%)                                                          
   Trachea                                            (49)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (2)                                                              
      Adenoma                                                       1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
   Urinary Bladder                                    (49)         (49)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)                                                             
      Lymphoma Malignant Histiocytic                   4 (8%)       6 (12%)                                                         
      Lymphoma Malignant Lymphocytic                   3 (6%)       5 (10%)                                                         
      Lymphoma Malignant Mixed                         5 (10%)      4 (8%)                                                          
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        600 PPM      600 PPM                                                             
                                                    10-10        0-10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          42                                                               
     Total Primary Neoplasms                           64          65                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 33          28                                                               
     Total Benign Neoplasms                            39          35                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          26                                                               
     Total Malignant Neoplasms                         23          30                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           3                                                               
     Total Metastatic Neoplasm                          3           3                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          2                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        O PPM        30 PPM       100 PPM      100 PPM      100 PPM         
                                                   0-0           10-0         1-1          10-3         3-3          0-3            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 6            8            2            7           10            3           
    Natural Death                                      5            5            9            6            7            6           
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           36           38           36           33           39           
    Moribund Sacrifice                                 1                                                                            
    Natural Death                                                   1            1                                      1           
  Missing                                                                                     1                         1           
  Animals Examined Microscopically                    50           50           50           49           50           49           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (11)         (8)          (11)         (10)         (5)          
   Intestine Large, Rectum                            (47)         (13)         (11)         (12)         (15)         (8)          
   Intestine Small, Duodenum                          (48)         (12)         (9)          (10)         (15)         (7)          
   Intestine Small, Ileum                             (48)         (11)         (13)         (11)         (14)         (6)          
   Intestine Small, Jejunum                           (50)         (12)         (17)         (10)         (16)         (8)          
   Liver                                              (50)         (50)         (50)         (49)         (50)         (49)         
      Cholangiocarcinoma                                                         1 (2%)                                             
      Hemangiosarcoma                                  4 (8%)       1 (2%)                                              1 (2%)      
      Hemangiosarcoma, Multiple                        1 (2%)       2 (4%)                    4 (8%)       1 (2%)       1 (2%)      
      Hepatoblastoma                                                                                       1 (2%)       1 (2%)      
      Hepatoblastoma, Multiple                                                   1 (2%)                                             
      Hepatocellular Carcinoma                        11 (22%)     10 (20%)     11 (22%)     11 (22%)     14 (28%)     11 (22%)     
      Hepatocellular Carcinoma, Multiple               2 (4%)       4 (8%)       2 (4%)       7 (14%)      4 (8%)       3 (6%)      
      Hepatocellular Adenoma                          14 (28%)     11 (22%)     10 (20%)     10 (20%)     15 (30%)     11 (22%)     
      Hepatocellular Adenoma, Multiple                 5 (10%)     12 (24%)      6 (12%)     13 (27%)      5 (10%)      8 (16%)     
      Hepatocholangiocarcinoma                                      1 (2%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                                                          1 (2%)      
   Mesentery                                          (3)          (2)          (2)                       (3)                       
      Hepatocholangiocarcinoma, Metastatic                          1 (50%)                                                         
      Sarcoma                                                                    1 (50%)                                            
   Pancreas                                           (50)         (13)         (11)         (13)         (17)         (8)          
      Sarcoma, Metastatic, Mesentery                                             1 (9%)                                             
   Salivary Glands                                    (50)         (13)         (12)         (13)         (17)         (9)          
   Stomach, Forestomach                               (50)         (16)         (11)         (18)         (15)         (9)          
      Squamous Cell Papilloma                                       2 (13%)                                2 (13%)                  
   Stomach, Glandular                                 (50)         (15)         (9)          (16)         (13)         (9)          
      Adenoma                                                                                                           1 (11%)     
   Tongue                                                                                                 (1)                       
      Squamous Cell Carcinoma                                                                              1 (100%)                 
                                                             Page  11                                                               
NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        O PPM        30 PPM       100 PPM      100 PPM      100 PPM         
                                                   0-0           10-0         1-1          10-3         3-3          0-3            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (14)         (12)         (13)         (17)         (10)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (8%)                                             
      Cholangiocarcinoma, Metastatic, Liver                                      1 (8%)                                             
      Hemangiosarcoma                                  1 (2%)                                 2 (15%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (14)         (11)         (12)         (17)         (9)          
      Corticomedullary Junction, Hepatocellular                                                                                     
          Carcinoma, Metastatic, Liver                 1 (2%)                                                                       
   Adrenal Gland, Cortex                              (50)         (14)         (11)         (12)         (17)         (9)          
      Adenoma                                                       1 (7%)                                                          
   Adrenal Gland, Medulla                             (50)         (14)         (11)         (11)         (17)         (9)          
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (13)         (10)         (12)         (17)         (8)          
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (45)         (11)         (4)          (10)         (14)         (7)          
      Pars Distalis, Carcinoma                                                   1 (25%)                                            
      Pars Intermedia, Carcinoma                                                              1 (10%)                               
   Thyroid Gland                                      (49)         (14)         (11)         (13)         (17)         (9)          
      Follicular Cell, Adenoma                                      1 (7%)       1 (9%)                                 1 (11%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (5)          (2)          (4)          (2)          (3)          (8)          
      Adenoma                                          1 (20%)                                                                      
      Hemangiosarcoma                                                                                                   1 (13%)     
   Prostate                                           (50)         (14)         (12)         (13)         (17)         (9)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (14)         (11)         (13)         (18)         (9)          
      Femoral, Hemangiosarcoma                         2 (4%)                                                                       
   Lymph Node                                         (50)         (30)         (32)         (27)         (31)         (23)         
      Deep Cervical, Carcinoma, Metastatic, Ear                     1 (3%)                                                          
                                                             Page  12                                                               
NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        O PPM        30 PPM       100 PPM      100 PPM      100 PPM         
                                                   0-0           10-0         1-1          10-3         3-3          0-3            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Mandibular, Fibrosarcoma, Metastatic, Skin       1 (2%)                                                                       
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                                   1 (4%)                                
      Mediastinal, Cholangiocarcinoma, Metastatic,                                                                                  
           Liver                                                                 1 (3%)                                             
   Lymph Node, Mesenteric                             (22)         (22)         (20)         (16)         (20)         (15)         
      Hemangiosarcoma                                  1 (5%)                                                           1 (7%)      
   Spleen                                             (49)         (21)         (18)         (20)         (25)         (17)         
      Hemangiosarcoma                                  4 (8%)       2 (10%)                   3 (15%)                               
   Thymus                                             (37)         (8)          (7)          (7)          (10)         (7)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (15)         (13)         (14)         (20)         (9)          
      Squamous Cell Carcinoma                                                                 1 (7%)                                
      Subcutaneous Tissue, Fibroma                                  2 (13%)                                                         
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (7%)                    1 (7%)       1 (5%)       1 (11%)     
      Subcutaneous Tissue, Lipoma                                                1 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (30)         (40)         (30)         (37)         (35)         
      Osteosarcoma                                                  1 (3%)                                                          
   Skeletal Muscle                                    (1)          (1)          (1)                                                 
      Hemangiosarcoma                                               1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (14)         (12)         (13)         (18)         (10)         
      Carcinoma, Metastatic, Pituitary Gland                                     1 (8%)       1 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (19)         (19)         (21)         (20)         (22)         
      Adenocarcinoma, Metastatic, Harderian Gland                                                          1 (5%)                   
      Alveolar/Bronchiolar Adenoma                     6 (12%)      8 (42%)      5 (26%)      5 (24%)      3 (15%)      2 (9%)      
      Alveolar/Bronchiolar Carcinoma                   4 (8%)       3 (16%)      2 (11%)      3 (14%)      1 (5%)       6 (27%)     
      Alveolar/Bronchiolar Carcinoma, Multiple                      2 (11%)      2 (11%)      1 (5%)       1 (5%)       3 (14%)     
      Carcinoma, Metastatic, Ear                                    1 (5%)                                                          
      Cholangiocarcinoma, Metastatic, Liver                                      1 (5%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      6 (12%)      2 (11%)      3 (16%)      5 (24%)      4 (20%)      2 (9%)      
      Hepatocholangiocarcinoma, Metastatic                          1 (5%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
                                                             Page  13                                                               
NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        O PPM        30 PPM       100 PPM      100 PPM      100 PPM         
                                                   0-0           10-0         1-1          10-3         3-3          0-3            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
          Site                                                                                                          1 (5%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                                                              
      Basal Cell Carcinoma                                          1 (100%)                                                        
   Harderian Gland                                    (9)          (2)          (2)          (2)          (3)          (4)          
      Adenocarcinoma                                   1 (11%)                   1 (50%)                   1 (33%)                  
      Adenoma                                          5 (56%)      2 (100%)     1 (50%)      1 (50%)      2 (67%)      4 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (16)         (12)         (13)         (18)         (9)          
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                 1 (8%)                                
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                                                          1 (11%)     
      Sarcoma, Metastatic, Mesentery                                             1 (8%)                                             
      Renal Tubule, Carcinoma                                                                              1 (6%)                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(49)        *(50)        *(49)         
      Lymphoma Malignant Histiocytic                   2 (4%)       2 (4%)       1 (2%)       2 (4%)       4 (8%)       2 (4%)      
      Lymphoma Malignant Lymphocytic                   5 (10%)                                2 (4%)       2 (4%)                   
      Lymphoma Malignant Mixed                         5 (10%)      8 (16%)      5 (10%)      3 (6%)       5 (10%)      5 (10%)     
      Lymphoma Malignant Undifferentiated Cell                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  14                                                               
NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        O PPM        30 PPM       100 PPM      100 PPM      100 PPM         
                                                   0-0           10-0         1-1          10-3         3-3          0-3            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            43          43          33          42          45          39               
     Total Primary Neoplasms                           77          79          53          70          64          63               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 25          32          20          26          24          22               
     Total Benign Neoplasms                            33          39          24          29          27          27               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              29          31          24          29          34          31               
     Total Malignant Neoplasms                         44          40          29          41          37          36               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              7           4           7           6           5           3               
     Total Metastatic Neoplasm                          9           6          10           8           5           5               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                           1               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  15                                                               
NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          300 PPM      300 PPM                                                             
                                                    10-10        0-10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 4            9                                                               
    Natural Death                                      2            7                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                44           34                                                               
  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (44)         (46)                                                             
   Intestine Large, Cecum                             (47)         (47)                                                             
   Intestine Large, Colon                             (48)         (50)                                                             
   Intestine Small, Duodenum                          (49)         (48)                                                             
   Intestine Small, Ileum                             (49)         (46)                                                             
   Intestine Small, Jejunum                           (48)         (48)                                                             
   Liver                                              (50)         (49)                                                             
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
      Hemangiosarcoma, Multiple                        2 (4%)                                                                       
      Hepatocellular Carcinoma                        18 (36%)      7 (14%)                                                         
      Hepatocellular Carcinoma, Multiple               2 (4%)                                                                       
      Hepatocellular Adenoma                          12 (24%)     11 (22%)                                                         
      Hepatocellular Adenoma, Multiple                19 (38%)     11 (22%)                                                         
      Sarcoma, Metastatic, Uncertain Primary Site      1 (2%)                                                                       
   Mesentery                                          (3)          (4)                                                              
      Sarcoma, Metastatic, Uncertain Primary Site      1 (33%)                                                                      
   Pancreas                                           (49)         (49)                                                             
   Tooth                                              (44)         (39)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)                                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (48)                                                             
      Capsule, Adenoma                                              1 (2%)                                                          
   Adrenal Gland, Cortex                              (49)         (49)                                                             
   Adrenal Gland, Medulla                             (49)         (45)                                                             
      Pheochromocytoma Benign                                       1 (2%)                                                          
                                                             Page  16                                                               
NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          300 PPM      300 PPM                                                             
                                                    10-10        0-10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Prostate                                           (50)         (50)                                                             
   Testes                                             (50)         (50)                                                             
      Interstitial Cell, Adenoma                                    2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)                                                             
      Femoral, Mast Cell Tumor NOS                     1 (2%)                                                                       
   Lymph Node                                         (50)         (47)                                                             
   Lymph Node, Mesenteric                             (18)         (24)                                                             
      Sarcoma, Metastatic, Uncertain Primary Site      1 (6%)                                                                       
   Spleen                                             (49)         (47)                                                             
      Hemangiosarcoma                                  2 (4%)                                                                       
   Thymus                                             (43)         (41)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)                                                             
      Subcutaneous Tissue, Fibrous Histiocytoma        1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  17                                                               
NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          300 PPM      300 PPM                                                             
                                                    10-10        0-10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)                                                             
      Adenocarcinoma, Metastatic, Harderian Gland                   1 (2%)                                                          
      Alveolar/Bronchiolar Adenoma                     7 (14%)      4 (8%)                                                          
      Alveolar/Bronchiolar Carcinoma                   4 (8%)       2 (4%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      7 (14%)      1 (2%)                                                          
      Sarcoma, Metastatic, Uncertain Primary Site      1 (2%)                                                                       
      Mediastinum, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (5)                                                              
      Adenocarcinoma                                                1 (20%)                                                         
      Adenoma                                          3 (75%)      3 (60%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)                                                             
      Lymphoma Malignant Histiocytic                                3 (6%)                                                          
      Lymphoma Malignant Lymphocytic                   3 (6%)       3 (6%)                                                          
      Lymphoma Malignant Mixed                         3 (6%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  18                                                               
NTP Experiment-Test: 05075-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 15:42:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          300 PPM      300 PPM                                                             
                                                    10-10        0-10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          36                                                               
     Total Primary Neoplasms                           79          53                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 36          26                                                               
     Total Benign Neoplasms                            41          33                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          16                                                               
     Total Malignant Neoplasms                         37          20                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              9           2                                                               
     Total Metastatic Neoplasm                         13           2                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  19                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------