National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2129

TDMS Study 05075-02 Pathology Tables

NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97
Route: DOSED FEED                                                                                                 Time: 07:40:15




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57-41-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 7| 3| 3| 3| 4| 4| 3|             
                                           | 6| 6| 6| 6| 0| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 0| 9| 0| 0| 9| 9| 9| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       3                                                                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 3                                                                        |             
      Clear Cell Focus                     |                            1                                             |             
      Fatty Change                         |                                              2                           |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct, Multifocal                  |             2                                      2                     |             
      Regeneration, Diffuse                |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +        +            |             
      Fat, Necrosis                        |                                                             3            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2     3  3                                                               |             
      Acinus, Focal Cellular Change        |                                                                          |             
      Duct, Dilatation                     |          3                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                        +           +           +         |             
      Incisor, Upper, Dysplasia            |                                        1                       1         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic Active       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |    1  1                                                                  |             
      Necrosis                             |                                                                          |             
      Corticomedullary Junction,           |                                                                          |             
          Degeneration, Fatty              |       3                             3           3                    4   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 7| 3| 3| 3| 4| 4| 3|             
                                           | 6| 6| 6| 6| 0| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 0| 9| 0| 0| 9| 9| 9| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Hyperplasia           |       2                    3  1        1  1  1        1  1        1     1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                   1  1   |             
      Follicular Cell, Hyperplasia         |       1                          1                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             4            |             
      Cyst                                 |       X           X        X  X     X  X  X     X  X  X  X  X  X        X|             
      Mineralization                       |                                  2                                       |             
      Thrombosis                           |                                                             X            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                   3  2  2        2     2        2        2     2        2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          +  +                                                            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        | 1                                                                        |             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +                                                              +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +        +                          +        +                 +      |             
      Angiectasis                          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                               1                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Necrosis                             |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 7| 3| 3| 3| 4| 4| 3|             
                                           | 6| 6| 6| 6| 0| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 0| 9| 0| 0| 9| 9| 9| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage                           |                                                    1                     |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               1  2                                   2   |             
      Alveolar Epithelium, Hyperplasia     |                               2        3                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +                             +      |             
      Hyperplasia                          |                                     1                                    |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |    1                                         1  1        1  1  1  1      |             
      Glomerulus, Inflammation,            |                                                                          |             
          Membranoproliferative            |             3                                                            |             
      Renal Tubule, Necrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 2| 4| 3| 5| 4| 4| 1|            |
                                           | 0| 8| 0| 3| 3| 3| 3| 4| 4| 4| 9| 4| 4| 5| 1| 5| 5| 5| 6| 5| 1| 5| 6| 6| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Basophilic Focus                     |                                                                          |      1  3.0|
      Clear Cell Focus                     |                                                                          |      1  1.0|
      Fatty Change                         |                                                       3                  |      2  2.5|
      Hematopoietic Cell Proliferation     |                                        1                          2      |      2  1.5|
      Infarct, Multifocal                  |    2                          2           2                       3      |      6  2.2|
      Regeneration, Diffuse                |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +  +     +  +     +                    +   |   8        |
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
      Acinus, Atrophy                      |                                                 4  1     2               |      6  2.5|
      Acinus, Focal Cellular Change        |                                                       X                  |      1     |
      Duct, Dilatation                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +                                      +                  |   5        |
      Incisor, Upper, Dysplasia            |                2                                                         |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic Active       |    3                                               1                     |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Hypertrophy                          |                2                                                         |      3  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   5                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 2| 4| 3| 5| 4| 4| 1|            |
                                           | 0| 8| 0| 3| 3| 3| 3| 4| 4| 4| 9| 4| 4| 5| 1| 5| 5| 5| 6| 5| 1| 5| 6| 6| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                               3                                          |      1  3.0|
      Corticomedullary Junction,           |                                                                          |            |
          Degeneration, Fatty              |                                                 4                        |      5  3.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Hyperplasia                          |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  I  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Pars Distalis, Hyperplasia           |          2  1        2     2        2              1  1  2              2|     19  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic Active         |       1                                                                  |      3  1.0|
      Follicular Cell, Hyperplasia         |             1                                   3                        |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                              +                           |   1        |
      Duct, Dilatation                     |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  4.0|
      Cyst                                 | X           X  X  X     X  X  X                    X  X           X     X|     25     |
      Mineralization                       |                                                                          |      1  2.0|
      Thrombosis                           |                      X                                                   |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                         2                                                |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                      1     1        2           2        2        1      |     15  1.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Myelofibrosis                        |                                                                          |      1  1.0|
      Femoral, Myelofibrosis               |                            2                    2                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +              +           +  +     +              +                  |  12        |
      Angiectasis                          |                               3                       2                  |      3  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                               3        3  3                       1     2|      6  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 2| 4| 3| 5| 4| 4| 1|            |
                                           | 0| 8| 0| 3| 3| 3| 3| 4| 4| 4| 9| 4| 4| 5| 1| 5| 5| 5| 6| 5| 1| 5| 6| 6| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  M  M|  42        |
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Cystic                  |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                   4      |      1  4.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                X         |      1     |
      Hemorrhage                           |    2                                                                     |      2  1.5|
      Necrosis                             |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      3  1.7|
      Alveolar Epithelium, Hyperplasia     |                                        2                    2            |      4  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Inflammation, Suppurative    |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                          +                  |   2        |
      Degeneration                         |                            4                          4                  |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +        +        +     +                 +        +                  |   8        |
      Hyperplasia                          |                      2                       3                           |      3  2.0|
      Inflammation, Chronic Active         |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Nephropathy, Chronic                 |                1  1  1     1                 1           1     1         |     14  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 2| 4| 3| 5| 4| 4| 1|            |
                                           | 0| 8| 0| 3| 3| 3| 3| 4| 4| 4| 9| 4| 4| 5| 1| 5| 5| 5| 6| 5| 1| 5| 6| 6| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Glomerulus, Inflammation,            |                                                                          |            |
          Membranoproliferative            |                                                                          |      1  3.0|
      Renal Tubule, Necrosis               |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 9| 3| 0| 3| 4| 3| 3| 7| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 6| 8| 1| 6| 3| 6| 8| 6| 7| 9| 7| 7| 4| 7| 7| 8| 8| 8| 0| 8| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +     +     A        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +     +     +        A        +     +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +     +     A        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                             X            |             
      Eosinophilic Focus                   |                                                                      3   |             
      Infarct, Multifocal                  |                   2                       3                              |             
      Infiltration Cellular, Lymphocyte    |                         2                                                |             
      Mixed Cell Focus                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +     +        +        +     +           +                  |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +        +  +     +     +           +                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +        +  +     +     +           +                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +     +     +        +        +     +           +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +     +        +        +     +           +                  |             
      Mineralization                       |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +     +     +        +        +     +           +                  |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +     A        +  +     +     M  +  +     +           +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +     +        +        +     +           +                  |             
      Follicular Cell, Hyperplasia         |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +     +  +  +        +     +  +  +  +     +  +  +        +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 9| 3| 0| 3| 4| 3| 3| 7| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 6| 8| 1| 6| 3| 6| 8| 6| 7| 9| 7| 7| 4| 7| 7| 8| 8| 8| 0| 8| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                                      3   |             
      Cyst                                 |             X  X                 X  X  X        X  X           X     X  X|             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +  +  +  +        +  +  +  +  +     +     +           +|             
      Dilatation                           |                                                             3            |             
      Endometrium, Hyperplasia, Cystic     |          1  3  1        2           1  2     1  2                       3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +     +        +        +     +           M        +         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                           +                    +         |             
      Angiectasis                          |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +     +        +     +           +        +         |             
      Hematopoietic Cell Proliferation     |             2                                                            |             
      Hyperplasia, Lymphoid                |                      3                                                   |             
      Necrosis                             |    3                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +     I     M        +        +     +           +                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +     +     +        +        +     +           +                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +     +        +        +     +           +                  |             
      Compression                          |                                                       X                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +     +     +        +        +     +     +     +  +               |             
      Inflammation, Chronic Active         |             1                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +     +     +        +        +     +           +                  |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +     +     +        +        +     +           +                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 9| 3| 0| 3| 4| 3| 3| 7| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 6| 8| 1| 6| 3| 6| 8| 6| 7| 9| 7| 7| 4| 7| 7| 8| 8| 8| 0| 8| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +     +     +        +        +     +           +                  |             
      Nephropathy, Chronic                 |                                     1                 1                  |             
      Glomerulus, Inflammation,            |                                                                          |             
          Membranoproliferative            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +     +     M        +        +     +           +                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 3|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 0| 6| 0| 4| 4| 8| 4| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 8| 6|            |
                                           | 0| 0| 0| 3| 3| 3| 7| 0| 7| 3| 4| 0| 4| 4| 4| 5| 5| 2| 5| 5| 3| 6| 6| 6| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                   +  +  +        +                 +        +        +  +|  16        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                   +  +  +        +                 +        +        +  A|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                   +  +  +        +                 +        +        +  +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                   +  +  +        +                 +        +        +  A|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                   +  +  +        +                 +        +        +  +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                   +  +  +        +                 +        +        +  A|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                   +  +  +        +                 +        +     +  +  +|  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                   +  +  +        +                 +        +        +  A|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                   +  +  +        +                 +        +        +  +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                   +  +  +        +                 +        +     +  +  A|  16        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                                    X                     |      2     |
      Eosinophilic Focus                   |                                                                          |      1  3.0|
      Infarct, Multifocal                  |                            2     2                          2            |      5  2.2|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Mixed Cell Focus                     | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +                                       |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                   +  +  +        +                 +        +        +  A|  15        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                   +  +  M        +                 +        +        +  +|  15        |
      Necrosis                             |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                   +  +  +        +           +     +        +        +  +|  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                   +  +  +        +           +     +        +        +  +|  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                   +  +  +        +                 +        +        +  +|  16        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                   +  +  +        +                 +        +        +  +|  16        |
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                   +  +  +        +                 +        +        +  +|  16        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                   +  +  +        +                 +        +        +  +|  16        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                   +  +  +        +                 +        +        +  +|  16        |
      Hyperplasia                          |                                                                         1|      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                   +  +  +        +                 +        +        +  A|  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                   +  +  +        +                 +        +        +  +|  16        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +        +  +  M        +                 +        +        +  +|  19        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                   +  +  +        +                 +        +        +  +|  16        |
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 3|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 0| 6| 0| 4| 4| 8| 4| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 8| 6|            |
                                           | 0| 0| 0| 3| 3| 3| 7| 0| 7| 3| 4| 0| 4| 4| 4| 5| 5| 2| 5| 5| 3| 6| 6| 6| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +           +  +  +        +        +     +  +        +     +  +  +|  28        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |       X                 X        X        X     X           X     X      |     17     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +  +  +  +  +  +  +        +  +  +  +  +  +  +        +  +  +  +  +|  36        |
      Dilatation                           |                                              3                           |      2  3.0|
      Endometrium, Hyperplasia, Cystic     |       1  1  1  2                    3  1  1                    3  1      |     18  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                   +  +  +        +                 +        +        +  +|  16        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +  +  M        +        +        +        +  +  +  +  +|  18        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                      +                    +        +           +  +      |   7        |
      Angiectasis                          |                                                    3           3         |      2  3.0|
      Necrosis                             |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +        +  +  +  +     +           +     +        +        +  +|  23        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                              3                           |      2  3.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                   +  +  M        +                 +        +        +  M|  12        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                   +  +  M        +                 +        +        +  +|  15        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                   +  +  +        +                 +        +        +  +|  16        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                   +  +  +        +                 +        +        +  +|  16        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                   +  +  +        +                 +        +        +  +|  16        |
      Compression                          |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                   +  +  +     +  +           +     +        +        +  +|  20        |
      Inflammation, Chronic Active         |                               3                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                   +  +  +        +                 +        +        +  +|  16        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                   +  +  +        +                 +        +        +  +|  16        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 3|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 0| 6| 0| 4| 4| 8| 4| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 8| 6|            |
                                           | 0| 0| 0| 3| 3| 3| 7| 0| 7| 3| 4| 0| 4| 4| 4| 5| 5| 2| 5| 5| 3| 6| 6| 6| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       M                       +        +                                 |   2        |
      Cornea, Inflammation, Chronic Active |                               3        2                                 |      2  2.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +        +                          +      |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                   +  +  +        +                 +        +        +  +|  16        |
      Nephropathy, Chronic                 |                                  1                                   1   |      4  1.0|
      Glomerulus, Inflammation,            |                                                                          |            |
          Membranoproliferative            |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                   +  +  +        +                 +        +        +  +|  15        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 9| 1| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 4| 2| 4|             
                                           | 6| 6| 8| 0| 9| 6| 6| 4| 7| 7| 7| 7| 7| 8| 8| 5| 8| 8| 9| 9| 9| 9| 0| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    60 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +        +                 +     +  +                 +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +        +                 +     +  +                 +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +        +                       +                       +   |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |                1                                                        1|             
      Fatty Change                         | 1                                                                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct, Multifocal                  |                                                                      3   |             
      Necrosis, Focal                      |                2                                                         |             
      Centrilobular, Cytomegaly            | 1                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                       +                    +      |             
      Inflammation, Suppurative            |                                                                          |             
      Artery, Inflammation, Chronic Active |                                              2                           |             
      Fat, Necrosis                        |                                                                   2      |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +        +                       +                       +   |             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +        +     +              +  +                 +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +        +                    +  +                 +     +   |             
      Cyst                                 |                                                                          |             
      Epithelium, Hyperplasia              |                                                                2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +        +     +                 +                       +   |             
      Cyst                                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Tongue                                  |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +        +                       +                       +   |             
      Artery, Inflammation, Chronic Active |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +        +                       +                       +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 9| 1| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 4| 2| 4|             
                                           | 6| 6| 8| 0| 9| 6| 6| 4| 7| 7| 7| 7| 7| 8| 8| 5| 8| 8| 9| 9| 9| 9| 0| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    60 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +  +        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +        +                       +              +        +   |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +        +                       +                       +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +     +  +  +        +     +  +  +     +  +  +  +  +  +  +  +|             
      Cyst                                 |    X     X        X  X  X        X     X  X        X  X  X  X  X  X     X|             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +  +  +  +           +        +  +  +              +  +  +   |             
      Dilatation                           |             3                                                            |             
      Inflammation, Suppurative            |                                           2                              |             
      Endometrium, Hyperplasia, Cystic     | 1     2  2  2     1              2              1              2  2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  A        +                       +                       +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +        +                       +                 +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +                 +                                         +         |             
      Angiectasis                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  A  +     +        +           +  +        +     +  +  +  +   |             
      Hematopoietic Cell Proliferation     |                2                                      1     1     3      |             
      Hyperplasia, Lymphoid                |                               3                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +        +                       +                       +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +     M        +                       +        +                  |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +        +                       +              +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +        +                       +                       +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +        +                       +                       +   |             
      Necrosis                             |                                              2                           |             
      Artery, Inflammation, Chronic Active |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +        +        +           +  +                       +   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +        +                       +                       +   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 9| 1| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 4| 2| 4|             
                                           | 6| 6| 8| 0| 9| 6| 6| 4| 7| 7| 7| 7| 7| 8| 8| 5| 8| 8| 9| 9| 9| 9| 0| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    60 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +        +                       +                       +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                     +  +      |             
      Hyperplasia                          |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +        +                    +  +                       +   |             
      Cyst                                 |                                                                          |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Regeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +        +                       +                       +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 4| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 8| 4| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 8| 4| 8| 6| 4| 4| 4| 4| 4|            |
                                           | 3| 6| 2| 0| 5| 8| 0| 3| 3| 3| 3| 4| 4| 4| 4| 1| 7| 5| 1| 5| 5| 5| 5| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    60 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +                             +  +     +  +               |  15        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +     +  +                             +  +     +  +               |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +  +              +        +     +  +     +  +        +      |  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     +  +              +        +     +  +     A  +        +      |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     +  +                             +  +     +  +               |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +  +                             +  +     A  +               |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +                             +  +     A  +               |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +  +                             +  +     A  +               |  14        |
      Inflammation, Acute, Necrotizing     |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +  +                             +  +     A  +               |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +     +  +                             +  +     A  +               |  14        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Eosinophilic Focus                   |                                     2                                    |      3  1.3|
      Fatty Change                         |                   1                    2           1        1     1      |      6  1.2|
      Hematopoietic Cell Proliferation     |                      3                                         3         |      2  3.0|
      Infarct, Multifocal                  | 4              3                                                         |      3  3.3|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Centrilobular, Cytomegaly            |                   1                                         1            |      3  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                  +               |   5        |
      Inflammation, Suppurative            |                                                          4               |      1  4.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                          4               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +  +                             +  +     +  +               |  15        |
      Inflammation, Chronic                |                                                          2               |      1  2.0|
      Acinus, Atrophy                      | 3                                            2                           |      2  2.5|
      Duct, Dilatation                     |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +  +                             +  +     M  +               |  14        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +  +                          +  +     +  +           +  +|  21        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +  +                          +  +     +  +           +  +|  20        |
      Cyst                                 |                                                                         X|      1     |
      Epithelium, Hyperplasia              |                                                                      1   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +                             +  +     +  +               |  16        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +                             +  +     +  +               |  15        |
      Artery, Inflammation, Chronic Active |                                                       2                  |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 4| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 8| 4| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 8| 4| 8| 6| 4| 4| 4| 4| 4|            |
                                           | 3| 6| 2| 0| 5| 8| 0| 3| 3| 3| 3| 4| 4| 4| 4| 1| 7| 5| 1| 5| 5| 5| 5| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    60 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     +  +                             +  +     M  +               |  14        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  +                             +  +     M  +               |  14        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +  +                             +  +     M  +               |  14        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  M  +     +  +                             +  +     +  +               |  14        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +     +  +                             +  +     A  +               |  14        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +                       +     +  +     M  +           +   |  17        |
      Pars Distalis, Hyperplasia           |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +                             +  +     +  +               |  15        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  M  M     +        +|  36        |
      Cyst                                 |       X  X     X     X  X  X     X  X     X  X  X  X           X        X|     29     |
      Thrombosis                           |                                                                X         |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +           +  +     +  +     +  +     +  +  +     +  +  +|  31        |
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                     2                                    |      2  2.0|
      Endometrium, Hyperplasia, Cystic     |    2                       4  1     2                       1     1     2|     16  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +  +                             +  +     +  +               |  15        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +                             +  +     M  +               |  16        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +        +                                                         |   5        |
      Angiectasis                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  +              +              +  +     +  +  +  +     +  +|  27        |
      Hematopoietic Cell Proliferation     | 3                                                                        |      5  2.0|
      Hyperplasia, Lymphoid                |                               2                                         4|      3  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M     +  +                             M  +     M  +               |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +        +  +                             +  +     M  +        +      |  12        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +  +                             +  +     +  +               |  17        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +                             +  +     +  +               |  16        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 4| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 8| 4| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 8| 4| 8| 6| 4| 4| 4| 4| 4|            |
                                           | 3| 6| 2| 0| 5| 8| 0| 3| 3| 3| 3| 4| 4| 4| 4| 1| 7| 5| 1| 5| 5| 5| 5| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    60 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  +                             +  +     +  +               |  15        |
      Necrosis                             |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +                          +  +  +     +  +           +   |  20        |
      Alveolar Epithelium, Hyperplasia     |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +  +                             +  +     +  +               |  15        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +                             +  +     +  +               |  15        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                      +   |   4        |
      Hyperplasia                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +                             +  +     +  +               |  16        |
      Cyst                                 |                X                                      X                  |      2     |
      Renal Tubule, Necrosis               |                                                          2               |      1  2.0|
      Renal Tubule, Regeneration           |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +  +                             +  +     +  +               |  15        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 6| 5| 5| 3| 3| 3| 3| 3| 4| 9| 4| 4|             
                                           | 6| 6| 6| 6| 7| 5| 1| 7| 7| 7| 8| 8| 8| 1| 6| 9| 8| 9| 9| 9| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                +  A                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +  +                    +  +  +           +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +  +                    +  +  +           +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +     +  +                    +  +  +        +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +     +  +                    +  +  +        +           +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                   X                                      3     X         |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                            2                             3     2         |             
      Fatty Change                         | 2  1  1  2  1        1  1     1  2              2     1  2     2     1   |             
      Infarct, Multifocal                  |                                           3                              |             
      Inflammation, Chronic                |                                                             2            |             
      Centrilobular, Congestion, Chronic   |                                              2                           |             
      Centrilobular, Cytomegaly            | 2  2  2  2           1  1     2  2  2           2     1  2     2         |             
      Hepatocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +           +            |             
      Inflammation, Suppurative            |                                                             4            |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis                        |                                                 3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +              +  +                    +  +  +     +           +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +              +  +                    +  +  +     +           +  +      |             
      Hyperplasia, Squamous                |                                                    2                     |             
      Epithelium, Hyperplasia              | 3                                                              2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +  +                    +  +  +     +              +      |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Incisor, Upper, Dysplasia            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +  +                    +  +  +                    +      |             
      Bacterium                            |                   X                                                      |             
      Cardiomyopathy, Chronic Active       |                                        3                                 |             
      Artery, Inflammation, Chronic Active |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +  +                    +  +  +                    +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 6| 5| 5| 3| 3| 3| 3| 3| 4| 9| 4| 4|             
                                           | 6| 6| 6| 6| 7| 5| 1| 7| 7| 7| 8| 8| 8| 1| 6| 9| 8| 9| 9| 9| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +  +  +                 +  M  +                    +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +     +  +                 +  +  +  +           +        +      |             
      Pars Distalis, Hyperplasia           |          3                          3                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +  +                 +  +  +                    +      |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +        +  +  +     +              +  +  +     +     +  +  +  +      |             
      Cyst                                 | X  X        X           X                 X  X     X     X     X  X      |             
      Inflammation, Chronic Active         |                                                             4            |             
                                            __________________________________________________________________________|             
   Uterus                                  |                +  +  +  +  +     +     +  +  +  +     +  +     +  +     +|             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                      1  2  2     2        1     2     2  1     2        1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +     +  +                    +  +  +        +           +      |             
      Lumbar, Edema                        |                                                                          |             
      Mandibular, Edema                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                       +                  |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +              +     +  +  +  +     +           +  +  +|             
      Hematopoietic Cell Proliferation     |                2                             2                           |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +  +                    +  M  +                    +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +  M                 +  +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Skin                                    |                +  +                    +  +  +                    +      |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +  +                    +  +  +                    +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +  +                    +  +  +                    +      |             
      Meninges, Infiltration Cellular,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 6| 5| 5| 3| 3| 3| 3| 3| 4| 9| 4| 4|             
                                           | 6| 6| 6| 6| 7| 5| 1| 7| 7| 7| 8| 8| 8| 1| 6| 9| 8| 9| 9| 9| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Lymphocyte                      |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +     +  +                    +  +  +                    +      |             
      Hemorrhage, Chronic                  |                                              2                           |             
      Inflammation, Chronic Active         |                1                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    |                +  +                    +  +  +                    +      |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +  +                    +  +  +                    +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +           +                                 |             
      Hyperplasia                          |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                +  +                    +  +  +                    +      |             
      Nephropathy, Chronic                 |                1                       3                                 |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Glomerulus, Inflammation,            |                                                                          |             
          Membranoproliferative            |                                                                          |             
      Pelvis, Inflammation, Suppurative    |                                                                          |             
      Renal Tubule, Necrosis               |                   3                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +  +                    +  +  +                    +      |             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|            |
                             DAY ON TEST   | 3| 4| 3| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 7| 7|            |
                                           | 5| 3| 5| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +     +                 +  +                                      +  +  +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +                 +  +                                      +  +  +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A     +                 +  +                 +           +  +     +  +  +|  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A     +                 +  +                                      +  +  +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A     +                 +  +                 +              +     +  +  +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A     +                 +  +                             +        +  +  +|  15        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      3  3.0|
      Degeneration, Cystic                 |    2                                                                     |      1  2.0|
      Eosinophilic Focus                   |                                                 2              2         |      5  2.2|
      Fatty Change                         |          1  2     1           2  2  2  2  2  2  2  1  3                  |     26  1.6|
      Infarct, Multifocal                  |                                                             2            |      2  2.5|
      Inflammation, Chronic                |                      2           2                                   2  2|      5  2.0|
      Centrilobular, Congestion, Chronic   |                                                                          |      1  2.0|
      Centrilobular, Cytomegaly            |    2     1  2  1  1           2     2  2  2  2  2  1  2                  |     26  1.7|
      Hepatocyte, Necrosis                 |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                +     +   |   4        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic Active |                                                                      3   |      1  3.0|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | A     +                 +  +                                      +  +  +|  12        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +                 +  +                                   +  +  +  +|  14        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | A     +  +              +  +  +  +  +  +                          +  +  +|  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | A     +  +              +  +  +  +  +  +                          +  +  +|  20        |
      Hyperplasia, Squamous                |          3                       3                                   2   |      4  2.5|
      Epithelium, Hyperplasia              |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | A     +  +              +  +     +                                +  +  +|  15        |
      Artery, Inflammation, Chronic Active |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +                                                                        |   1        |
      Incisor, Upper, Dysplasia            | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +                 +  +                                      +  +  +|  13        |
      Bacterium                            |                                                                          |      1     |
      Cardiomyopathy, Chronic Active       |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|            |
                             DAY ON TEST   | 3| 4| 3| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 7| 7|            |
                                           | 5| 3| 5| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Artery, Inflammation, Chronic Active |                                                                      3   |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | A     +                 +  +                                      +  +  +|  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +                 +  +                       +              +  +  +|  17        |
      Pars Distalis, Hyperplasia           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +                 +  +                                      +  +  +|  14        |
      Follicular Cell, Hyperplasia         |                                                                         1|      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                               +                                          |   1        |
      Duct, Dilatation                     |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +  +  +  +        +  +  +  +     +        +                 +  +  +|  28        |
      Cyst                                 |       X        X        X     X  X     X                                 |     16     |
      Inflammation, Chronic Active         |       2  3                                                        4  4  4|      6  3.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +        +  +  +  +  +  +  +  +     +     +  +           +  +  +|  33        |
      Dilatation                           |                                                    3                     |      1  3.0|
      Inflammation, Chronic Active         |                      2                                                  4|      2  3.0|
      Inflammation, Suppurative            | 2                                                                 2      |      2  2.0|
      Endometrium, Hyperplasia, Cystic     |    1     1        2        1  2  1  1  1     1        2                  |     20  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +        +        +  +                       +     +  +  +  +  +  +|  20        |
      Lumbar, Edema                        |                                                                         3|      1  3.0|
      Mandibular, Edema                    |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                  +     +  +  +         |   6        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +              +  +     +                 +        +  +  +  +  +|  23        |
      Hematopoietic Cell Proliferation     |                                                                      3  3|      4  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M     +                 +  +                                      M  +  M|   9        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|            |
                             DAY ON TEST   | 3| 4| 3| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 7| 7|            |
                                           | 5| 3| 5| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +                 +  +                                      +  +  +|  13        |
      Inflammation, Chronic Active         |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +                 +  +                                      +  +  +|  13        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +                 +  +                                      +  +  +|  13        |
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +                 +  +                 +                    +  +  +|  15        |
      Hemorrhage, Chronic                  |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                         3                                            2   |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +                 +  +                                      +  +  +|  13        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +                 +  +                                      +  +  +|  13        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +     +                                       |   2        |
      Degeneration                         |                            3     4                                       |      2  3.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                  +                                       |   3        |
      Hyperplasia                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +                 +  +                                      +  +  +|  13        |
      Nephropathy, Chronic                 |                                                                      1  1|      4  1.5|
      Artery, Inflammation, Chronic Active |                                                                      2   |      1  2.0|
      Glomerulus, Inflammation,            |                                                                          |            |
          Membranoproliferative            | 3                                                                        |      1  3.0|
      Pelvis, Inflammation, Suppurative    |                                                                         2|      1  2.0|
      Renal Tubule, Necrosis               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +                 +  +                                      +  +  +|  13        |
      Artery, Inflammation, Chronic Active |                                                                         1|      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 5| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 4| 3| 8| 3| 0| 3| 3| 3| 3| 4|             
                                           | 6| 6| 5| 6| 3| 6| 7| 7| 5| 7| 5| 7| 8| 8| 8| 3| 8| 7| 0| 2| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +     +           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +     A           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +     A           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +     A           +     A              +     +  +  +               |             
      Parasite Metazoan                    |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +     A           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +     A           +     M              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +     A           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +     A           +     M              +     +  +  +               |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +     A           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +     A           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                             X            |             
      Eosinophilic Focus                   |                                                 1                        |             
      Fatty Change                         |          1     2     3     1     2  2  2        2           1  1     2  1|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct, Multifocal                  |                                                          2               |             
      Inflammation, Chronic                |                                                                         2|             
      Centrilobular, Cytomegaly            |          1     1     1     1     2  1  1        1           2        1  2|             
      Hepatocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +              +                     |             
      Inflammation, Suppurative            |                                                    4                     |             
      Fat, Necrosis                        |                                     3                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +     A           +     +              +     +  +  +               |             
      Acinus, Atrophy                      |                                              3                           |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +     +           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +     A           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +     A           +     +              +     +  +  +               |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +     A           +     +              +     +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +     +           +     +              +     +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +     +           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +     +           +     +              +     +  +  +               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Corticomedullary Junction,           |                                                                          |             
          Degeneration, Fatty              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +     +           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +     A           +     +              +     +  +  +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 5| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 4| 3| 8| 3| 0| 3| 3| 3| 3| 4|             
                                           | 6| 6| 5| 6| 3| 6| 7| 7| 5| 7| 5| 7| 8| 8| 8| 3| 8| 7| 0| 2| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +     +           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +     +  +        +     +              +     +  +  +        +      |             
      Pars Distalis, Hyperplasia           |                         1                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +     +           +     +              +     +  +  +               |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +        +  +  +  +        +     +     +  +  +               |             
      Cyst                                 |    X  X  X           X     X           X              X                  |             
      Inflammation, Chronic Active         |                                              4     4                     |             
      Thrombosis                           |       X                                                                  |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +           +  +  +     +  +     +  +  +  +  +  +  +        +|             
      Dilatation                           |                         2                                      3         |             
      Inflammation, Suppurative            |                                              3     3                     |             
      Endometrium, Hyperplasia, Cystic     |    2  1  2                 3        2  2        2           2           2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +     +           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +     +     +     +              +     +  +  +     +         |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      |                                              3     3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                   +                                   +  +               |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +     +  +  +  +  +     +              +     +  +  +  +  +         |             
      Hematopoietic Cell Proliferation     |       1                                      3     3                     |             
      Hyperplasia, Lymphoid                |    2                 1                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +     A           +     +              +     +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +     +           +     M              +     M  +  +               |             
                                            __________________________________________________________________________|             
   Skin                                    |       +     +           +     +              +     +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +     +           +     +              +     +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +     +           +     +              +     +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +     +           +     +              +     +  +  +               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic Active         |       1                                            2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 5| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 4| 3| 8| 3| 0| 3| 3| 3| 3| 4|             
                                           | 6| 6| 5| 6| 3| 6| 7| 7| 5| 7| 5| 7| 8| 8| 8| 3| 8| 7| 0| 2| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +     +           +     +              +     +  +  +               |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +     +           +     +              +     +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                    +  +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +     +  +        +     +              +     +  +  +               |             
      Nephropathy, Chronic                 |                                              3                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +     +           +     +              +     +  +  +               |             
      Artery, Inflammation, Chronic Active |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 0| 0| 0| 9| 3| 3| 4| 3| 3| 4| 4| 4| 4| 5| 5| 5| 0| 5| 6| 6| 6| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +        +                          +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          +        +                          +  +                        |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +        +  +                       +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +        +                          +  +                        |  10        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +        +  +                       +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +        +                          +  +                        |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +        +                          +  +           +            |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +        +                          +  +                        |  10        |
      Inflammation, Acute, Necrotizing     |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +        +                          +  +                        |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +        +                          +  +           +            |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                        2                                 |      2  2.0|
      Eosinophilic Focus                   |                2                                         2  3            |      4  2.0|
      Fatty Change                         | 2     2        2     1  1  1  1  1     1  1  1     1              2  2  1|     27  1.5|
      Hematopoietic Cell Proliferation     |                                                 3                        |      1  3.0|
      Infarct, Multifocal                  |                                           2                              |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Centrilobular, Cytomegaly            | 2  1  1        2     1  1     1  2        1        1  1           1  1  1|     25  1.2|
      Hepatocyte, Necrosis                 |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                             +                        |   4        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +        +                       +  +  +                        |  12        |
      Acinus, Atrophy                      |                                           4                              |      2  3.5|
      Duct, Dilatation                     |                                           4                              |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +        +                          +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +        +     +                    +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +        +     +                    +  +                        |  12        |
      Cyst                                 |                         X                                                |      1     |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +        +                          +  +                        |  11        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +        +                          +  +                        |  12        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |          +        +                          +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +        +                          +  +                        |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 0| 0| 0| 9| 3| 3| 4| 3| 3| 4| 4| 4| 4| 5| 5| 5| 0| 5| 6| 6| 6| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                                                 3                        |      1  3.0|
      Corticomedullary Junction,           |                                                                          |            |
          Degeneration, Fatty              |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +        +                          +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +        +                          +  +                        |  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +        +                          +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +        +                          +  +                        |  14        |
      Pars Distalis, Hyperplasia           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +        +                          +  +                        |  12        |
      Follicular Cell, Hyperplasia         |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |          +  +     +     +        +        +  +  +  +  +     +     +      |  25        |
      Cyst                                 |             X     X     X        X        X           X     X     X      |     15     |
      Inflammation, Chronic Active         |                                                                          |      2  4.0|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +  +  +  +  +  +  +  +  +           +  +  +     +           +  +  +|  33        |
      Dilatation                           |                                                                          |      2  2.5|
      Inflammation, Suppurative            |                                                                      2   |      3  2.7|
      Endometrium, Hyperplasia, Cystic     |       1  3  2  2  2  3  3  2  2           2     3     1           1  1  2|     24  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +        +                          +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +        +                          +  +  +                     |  15        |
      Mediastinal, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                 +                        |   4        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +        +           +     +     +  +  +           +  +         |  23        |
      Hematopoietic Cell Proliferation     |                                                 2           2  2         |      6  2.2|
      Hyperplasia, Lymphoid                |                                           2                              |      3  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +        +                          +  +                        |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          M        +                          +  +                        |   9        |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +        +                          +  +                        |  12        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 0| 0| 0| 9| 3| 3| 4| 3| 3| 4| 4| 4| 4| 5| 5| 5| 0| 5| 6| 6| 6| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +        +                          +  +                        |  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +        +                          +  +        +               |  13        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +        +                       +  +  +                        |  13        |
      Hyperplasia, Lymphoid                |                                           2                              |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    |          +        +                          +  +                        |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +        +                          +  +                        |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                          +               |   1        |
      Degeneration                         |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                          +               |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +        +                    +     +  +                        |  14        |
      Nephropathy, Chronic                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +        +                          M  +                        |  11        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 6| 4| 6| 6| 7| 7| 7| 0| 2| 7| 8| 8| 8| 5| 8| 9| 9| 6| 9| 9| 9| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       A                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       A                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       A                 +  +              A           +                  |             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       A                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       A                 +  +              A           +                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       A                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       A                 +  +              A           +                  |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       A                 +  +              +           +                  |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       A                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                   X      |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                     2                             X      |             
      Fatty Change                         |    1     2     2  2  1           1           1        1     2        1  1|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct, Multifocal                  |                                           3        1                     |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Centrilobular, Cytomegaly            |    1     3     2  2  1        1  1  2        2     1     1  2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       A                 +  +              +           +                  |             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       A                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  A     +  +     +  +  +     +        +  +        +                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  A     +  +     +  +  +     +        +  +        +                  |             
      Hyperplasia, Squamous                |             3  2     2                                                   |             
      Epithelium, Hyperplasia              |    3                                         3                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       A     +  +     +  +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +                                             |             
      Incisor, Upper, Dysplasia            |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +                 +  +              +           +                  |             
      Bacterium                            |       X                                                                  |             
      Atrium, Thrombosis                   |                                                                          |             
      Valve, Inflammation, Suppurative     |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 6| 4| 6| 6| 7| 7| 7| 0| 2| 7| 8| 8| 8| 5| 8| 9| 9| 6| 9| 9| 9| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       A                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       A                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       A                 +  +              +           +                  |             
      Hyperplasia                          |                         1                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       A                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       A     +           +  +              A           +  +        M  +  +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       A                 +  +              +           +                  |             
      Follicular Cell, Hyperplasia         |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  A  +     +     +  +  +  +  +        +           +     +  +  +     +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |    X     X     X     X        X  X        X           X     X  X  X     X|             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  A     +  +        +  +        +     +     +  +  +     +        +   |             
      Fibrosis                             |    3                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                                                                      X   |             
      Endometrium, Hyperplasia, Cystic     | 3  2        2  2        1           2           1  2        2        1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       A                 +  +              +           +                  |             
      Femoral, Myelofibrosis               |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       A                 +  +     +     +  +        +  +                  |             
      Mandibular, Edema                    |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                         +              +           +                     |             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  A           +     +  +     +  +  +  +     +  +  +  +        +     +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       A                 +  +              A           +                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +                                   +           +                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 6| 4| 6| 6| 7| 7| 7| 0| 2| 7| 8| 8| 8| 5| 8| 9| 9| 6| 9| 9| 9| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    200 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +                 +  +              +           +                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +                 +  +              +           +                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +                 +  +              +           +                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +                 +  +              +           +                  |             
      Bacterium                            |       X                                                                  |             
      Inflammation, Acute                  |       3                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    |       +                 +  +              +           +                  |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +                 +  +              +           +                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                   +         |             
      Degeneration                         |                            4                                   3         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                 +                 +         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                                |             
      Dilatation                           |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +                 +  +              +           +                  |             
      Nephropathy, Chronic                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       A                 +  +              +           +                  |             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 4| 6| 4| 4| 4| 4| 4| 4| 4| 8| 3| 1| 4| 4| 4| 4| 4| 7| 4| 4| 4| 8| 4| 4| 7|            |
                                           | 0| 5| 3| 3| 3| 3| 4| 4| 4| 0| 0| 7| 4| 5| 5| 5| 5| 4| 6| 6| 6| 9| 6| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +                       +  +  +                 +           +        +|  12        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +                       +  +  +                 +           +        +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +        +     +        +  +  +                 +           +        +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +        +     +        +  +  +                 +           +        M|  11        |
      Fibrosis                             |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +                       +  +  +                 +           +        +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +                       +  +  +                 +           +        +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +                       +  +  +                 +           +        +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +                       +  +  +                 +           +        +|  10        |
      Inflammation, Acute, Necrotizing     |                                  2                             2         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +                       +  +  +                 +           +        +|  11        |
      Inflammation, Acute, Necrotizing     |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +                       +  +  +                 +           +        +|  11        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                   3                                                      |      1  3.0|
      Degeneration, Cystic                 |                                                                   1      |      1  1.0|
      Eosinophilic Focus                   |                                           2                              |      3  2.0|
      Fatty Change                         |       1  2  2  1  1  1  1                    2  1     1  1  2            |     23  1.3|
      Hematopoietic Cell Proliferation     |                                                                         2|      1  2.0|
      Infarct, Multifocal                  |                            2                                             |      3  2.0|
      Bile Duct, Hyperplasia               |                                                    3                     |      1  3.0|
      Centrilobular, Cytomegaly            |          2  2  2  2  2  2                    2  2     2  2  2  1  2      |     25  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +  +                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +                       +  +  +                 +           +        +|  11        |
      Inflammation, Chronic                |                                                    4                     |      1  4.0|
      Acinus, Atrophy                      |                            3                       3                     |      2  3.0|
      Duct, Hyperplasia                    |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +                       +  +  +                 +           +        +|  11        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +                       +  +  +                 +           +        +|  17        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +                       +  +  +                 +           +         |  16        |
      Hyperplasia, Squamous                |                                                                          |      3  2.3|
      Epithelium, Hyperplasia              |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +                       +  +  +                 +           +         |  13        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Incisor, Upper, Dysplasia            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +                       +  +  +                 +           +        +|  13        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 4| 6| 4| 4| 4| 4| 4| 4| 4| 8| 3| 1| 4| 4| 4| 4| 4| 7| 4| 4| 4| 8| 4| 4| 7|            |
                                           | 0| 5| 3| 3| 3| 3| 4| 4| 4| 0| 0| 7| 4| 5| 5| 5| 5| 4| 6| 6| 6| 9| 6| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Bacterium                            |                                                                          |      1     |
      Atrium, Thrombosis                   | X                                                                        |      1     |
      Valve, Inflammation, Suppurative     |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +                       +  +  +                 +           +        +|  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +                       +  +  +                 +           +        +|  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +                       +  +  +                 +           +        +|  11        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +                       +  +  +                 +           +        +|  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +                       +  +  M                 +           +        +|  11        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +           +     +     +  +  M                 M           +  +     +|  15        |
      Pars Distalis, Hyperplasia           |                      2        3                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +                       +  +  +                 +           +        +|  11        |
      Follicular Cell, Hyperplasia         |                            1                                             |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +        +     +     +  +  +     +        +  +     +  +  +  +     +|  30        |
      Angiectasis                          |                      3                                                   |      1  3.0|
      Cyst                                 | X     X        X           X  X  X     X        X        X  X  X        X|     24     |
      Fibrosis                             |                                                    4                     |      1  4.0|
      Inflammation, Chronic Active         |                                                                         4|      1  4.0|
      Thrombosis                           |                                                                   X      |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +     +  +     +  +  +  +  +  +        +  +     +  +  +  +  +  +  +  +|  32        |
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                         3|      1  3.0|
      Thrombosis                           |                                                                          |      1     |
      Endometrium, Hyperplasia, Cystic     |    2     2  1     2  1  2        1        3  2        1  2  3  2  1  2   |     25  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +                       +  +  +                 +           +        +|  11        |
      Femoral, Myelofibrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +              +        +  +  +     +  +        +  +        +  +  +  +|  20        |
      Mandibular, Edema                    |                   3                                                      |      1  3.0|
      Mandibular, Hyperplasia, Lymphoid    |                                        3                                 |      1  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                       3                  |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 4| 6| 4| 4| 4| 4| 4| 4| 4| 8| 3| 1| 4| 4| 4| 4| 4| 7| 4| 4| 4| 8| 4| 4| 7|            |
                                           | 0| 5| 3| 3| 3| 3| 4| 4| 4| 0| 0| 7| 4| 5| 5| 5| 5| 4| 6| 6| 6| 9| 6| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    200 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +        +  +                    +  +           +      |   9        |
      Angiectasis                          |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +                       +  +  +  +  +        +  +  +        +  +  +  +|  27        |
      Hematopoietic Cell Proliferation     |                                                                1     2  3|      3  2.0|
      Hyperplasia, Lymphoid                |                                        2              3                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +                       +  +  +                 +           +        +|  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +                                               +                     |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +                       +  +  +                 +        +  +        +|  13        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +                       +  +  +                 +           +        +|  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +                       +  +  +                 +           +        +|  12        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +                       +  +  +                 +           +        +|  13        |
      Bacterium                            |                                                                          |      1     |
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +                       +  +  +                 +           +        +|  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +                       +  +  +                 +           +        +|  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                        +                                 |   3        |
      Degeneration                         |                                        3                                 |      3  3.3|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                        +                                 |   4        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +                       +  +  +                 +           +        +|  12        |
      Nephropathy, Chronic                 |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +                       +  +  +                 +           +        +|  11        |
      Artery, Inflammation, Chronic Active |                                                                         3|      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 0| 3| 8| 7| 8| 8| 4| 8| 9| 0| 7| 9| 9| 9| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X     3                                                               |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   | X                                   X           2  2        X            |             
      Fibrosis, Multifocal                 |          2                                                               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct, Multifocal                  |          4              3  2        2                 2                  |             
      Mixed Cell Focus                     |                               2                                          |             
      Vacuolization Cytoplasmic            |                                  3                                       |             
      Centrilobular, Cytomegaly            | 1  2  2  2  1  1     1  2     1     1     1  1  2        2  2  1  1  1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +           +  +               |             
      Artery, Inflammation, Chronic Active |                                           2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                  1                             1         |             
      Acinus, Depletion Secretory          |                                                       3                  |             
      Artery, Inflammation, Chronic Active |                                           2                       3      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                        +                    +            |             
      Incisor, Upper, Dysplasia            |                                        1                    1            |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                     2     2                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 0| 3| 8| 7| 8| 8| 4| 8| 9| 0| 7| 9| 9| 9| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  I  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M|             
      Pars Distalis, Hyperplasia           |                   1           1     1  2        1  1  1     1  2  1  3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       2                                                                  |             
      Follicular Cell, Hyperplasia         |    1     1                    1  1     1        1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       3                  |             
      Cyst                                 |                      X        X        X     X     X                     |             
      Thrombosis                           |                                              X                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Inflammation, Suppurative            |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
      Femoral, Myelofibrosis               | 1                    1                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                  +                       +  +            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  I  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  M  +  +  +  +  +  M  M  +  +  +  M  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 0| 3| 8| 7| 8| 8| 4| 8| 9| 0| 7| 9| 9| 9| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                         1                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy, Chronic                 |          1     1     1                    1                       1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 3| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 8| 1| 4| 4| 4| 4| 4| 3| 4|            |
                                           | 0| 3| 3| 3| 3| 0| 4| 2| 4| 7| 4| 4| 5| 5| 5| 5| 7| 9| 6| 6| 6| 6| 6| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    600 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
      Edema                                |                                                                      3   |      1  3.0|
      Inflammation, Acute, Necrotizing     |                                                                      4   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                              3                           |      3  3.0|
      Clear Cell Focus                     |          2  1                                   X     X  X               |      5  1.5|
      Eosinophilic Focus                   |          2  3                                               3            |      8  2.4|
      Fibrosis, Multifocal                 |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                      2   |      1  2.0|
      Infarct, Multifocal                  |                   2                                                      |      6  2.5|
      Mixed Cell Focus                     |                                                          X               |      2  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
      Centrilobular, Cytomegaly            | 2     1  2  1           2     1  2  2     1  2  2  1  1  1  2  3  2     2|     37  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +     +                                               +   |   6        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |                                              1                 2        1|      5  1.2|
      Acinus, Depletion Secretory          |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Diverticulum                         |                                                                2         |      1  2.0|
      Inflammation, Chronic Active         |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +     +  +     +  +              +  +           +     +     +         |  12        |
      Incisor, Upper, Dysplasia            |    1     1  1                       1  1           1     1     1         |     10  1.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 3| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 8| 1| 4| 4| 4| 4| 4| 3| 4|            |
                                           | 0| 3| 3| 3| 3| 0| 4| 2| 4| 7| 4| 4| 5| 5| 5| 5| 7| 9| 6| 6| 6| 6| 6| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    600 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Chronic Active |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  44        |
      Pars Distalis, Hyperplasia           | 2     3              1        2     1        1                           |     17  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Inflammation, Chronic Active         | 1        1              2                                                |      4  1.5|
      Follicular Cell, Hyperplasia         | 1  1     2  1  2                 2  1  1              1                  |     15  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                   3                                                      |      2  3.0|
      Cyst                                 | X        X  X                             X  X  X     X     X            |     13     |
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |    3                 2                                                  2|      3  2.3|
      Inflammation, Suppurative            |                                                                         3|      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                +     +        +                                          |   3        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Femoral, Myelofibrosis               |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +        +                                                     +   |   6        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 3| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 8| 1| 4| 4| 4| 4| 4| 3| 4|            |
                                           | 0| 3| 3| 3| 3| 0| 4| 2| 4| 7| 4| 4| 5| 5| 5| 5| 7| 9| 6| 6| 6| 6| 6| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    600 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  M  +|  39        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Inflammation, Suppurative    |                   3                                                      |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Metaplasia, Osseous                  |                                              1                           |      1  1.0|
      Nephropathy, Chronic                 |                1  1  1                 1           1  1  1     1        1|     14  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 4| 4| 4| 4|             
                                           | 1| 6| 6| 6| 6| 7| 8| 7| 6| 7| 7| 8| 8| 8| 8| 3| 9| 7| 9| 9| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    600 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation, Acute, Necrotizing     |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X  1                                            X                  |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                            1                                1           1|             
      Eosinophilic Focus                   |    2     2           2                    3     2     3                  |             
      Infarct, Multifocal                  |                   1                 4              2                     |             
      Inflammation, Chronic                |                                                                          |             
      Centrilobular, Cytomegaly            |       1  2     1           1  2  1  1  1  2     2        1  1  2  2  1  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +     +                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |                                                       2        2         |             
      Acinus, Depletion Secretory          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +     +     +           +              +     +         |             
      Incisor, Upper, Dysplasia            |                   1           1           1              1     1         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  A  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   3                                                      |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Thrombosis                           |                         X                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 4| 4| 4| 4|             
                                           | 1| 6| 6| 6| 6| 7| 8| 7| 6| 7| 7| 8| 8| 8| 8| 3| 9| 7| 9| 9| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    600 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  I  +  +  +|             
      Pars Distalis, Hyperplasia           |    1  3  2  1        1                 1              1              2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                            1  1                 3  2  1  3  3  1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     4                                    |             
      Cyst                                 |             X                 X     X                       X  X  X      |             
      Thrombosis                           |                                     X                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                       3        3         |             
      Inflammation, Suppurative            |                                                       2                  |             
      Endometrium, Hyperplasia, Cystic     |       2     1                 3                          2               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                   +                                                      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |             1                 1                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +                       +              +                                 |             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Lymphoid                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  M  M  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 4| 4| 4| 4|             
                                           | 1| 6| 6| 6| 6| 7| 8| 7| 6| 7| 7| 8| 8| 8| 8| 3| 9| 7| 9| 9| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    600 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                      1   |             
      Alveolar Epithelium, Hyperplasia     |       2                                                  2               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |    1           1     1        1     1  1  1  1                       1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 6| 4| 8| 0| 4| 4| 4| 8| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 4| 2| 4| 2|            |
                                           | 3| 3| 3| 4| 3| 6| 9| 3| 4| 4| 4| 4| 4| 0| 9| 5| 5| 5| 5| 6| 6| 6| 9| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    600 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                               X                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Acute, Necrotizing     |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      4  1.0|
      Clear Cell Focus                     |                                                       X                  |      1     |
      Degeneration, Cystic                 | 1                                               1                        |      5  1.0|
      Eosinophilic Focus                   |          2                                            3                  |      8  2.4|
      Infarct, Multifocal                  |          1     2  3           3                    3              3  3  2|     11  2.5|
      Inflammation, Chronic                |                                           2        2                     |      2  2.0|
      Centrilobular, Cytomegaly            | 1  1  1           2     1  1     1  1           1  1  2  2  1  1     1   |     31  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +  +     +                                               +|   6        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |             2                                                            |      1  2.0|
      Acinus, Atrophy                      |                                                    4                     |      3  2.7|
      Acinus, Depletion Secretory          |                X                                                         |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +                             +     +                     |   9        |
      Incisor, Upper, Dysplasia            |                                              1     1                     |      7  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 6| 4| 8| 0| 4| 4| 4| 8| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 4| 2| 4| 2|            |
                                           | 3| 3| 3| 4| 3| 6| 9| 3| 4| 4| 4| 4| 4| 0| 9| 5| 5| 5| 5| 6| 6| 6| 9| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    600 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                  1                                       |      1  1.0|
      Hypertrophy                          |             2                                                     3      |      2  2.5|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | I  +  I  +  +  +  +  +  +  +  +  +  +  I  +  +  +  M  +  +  +  +  +  I  +|  41        |
      Pars Distalis, Hyperplasia           |                1     1  3  1     1  2                    1  2           1|     17  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         |             2              1        2                    2     2         |     13  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |       2                                                                  |      2  3.0|
      Cyst                                 |    X        X        X  X  X  X  X           X  X        X        X  X   |     18     |
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           | 3                                                                        |      3  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |    1  2     1                    2                                       |      8  1.8|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Myelofibrosis               |                                        1                                 |      3  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                         +           +                                   +|   6        |
      Angiectasis                          |                                     3                                    |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                3  2                                                      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|  45        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 6| 4| 8| 0| 4| 4| 4| 8| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 4| 2| 4| 2|            |
                                           | 3| 3| 3| 4| 3| 6| 9| 3| 4| 4| 4| 4| 4| 0| 9| 5| 5| 5| 5| 6| 6| 6| 9| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    600 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       X                                                                  |      1     |
      Mineralization                       |       4                                                                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                        2        2        2               |      4  1.8|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                          +               |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 |                            1        1  2  1  1     1        1        1   |     17  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 8| 3| 0| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 9| 4| 4| 4| 5| 5| 5| 0| 5| 6| 0| 6| 9| 8| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Necrotizing     |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                     X              X              2      |             
      Clear Cell Focus                     |                                              3  3     4  X               |             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |    2                                   2                                 |             
      Fatty Change                         |                                                 1  1  1        2         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct, Multifocal                  |                                        2  4                              |             
      Mixed Cell Focus                     |                   X                                                      |             
      Necrosis                             | 2                                                                        |             
      Regeneration, Diffuse                |                                                                          |             
      Bile Duct, Hyperplasia               |                2                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                       +      |             
      Inflammation, Suppurative            |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                   2      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                     2                 2                  |             
      Acinus, Focal Cellular Change        |                                                             X            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Necrotizing     |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +        +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +  +|             
      Incisor, Upper, Dysplasia            | 1        2  1  1  1  3     1  2     1     1  3  3  1  2  1  2  1  1  1  2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 8| 3| 0| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 9| 4| 4| 4| 5| 5| 5| 0| 5| 6| 0| 6| 9| 8| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |          2        2  3        1                       1     2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst Multilocular          |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +                          +                                    |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Dilatation                     |                                     3                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +              +                 +                          +            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +        +  +           +  +  +  +           +  +  +  +  +     +   |             
      Angiectasis                          |       3        3  2           3     1  2              3  2     2     2   |             
      Hyperplasia, Lymphoid                |                                     2                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                             2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                         +                                                |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 8| 3| 0| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 9| 4| 4| 4| 5| 5| 5| 0| 5| 6| 0| 6| 9| 8| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrosis, Focal               |                                                                          |             
      Tarsal, Hyperostosis                 |       X  X  X  X           X  X           X  X              X  X  X      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
      Artery, Inflammation, Chronic Active |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                   2      |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Focal, Squamous          |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    2  2              1     2     2           2                    3     3|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                1                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +        +                                                            |             
      Degeneration                         |             3                                                            |             
      Cornea, Inflammation, Chronic Active |    2                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +  +  +              +                                          |             
      Hyperplasia                          |                               1                                          |             
      Inflammation, Suppurative            |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy, Chronic                 | 1           1  2  1  1     1  1  1  1  2     1     1  1  1  1  2     2  1|             
      Artery, Inflammation, Chronic Active |                                                                   3      |             
      Pelvis, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 7| 4| 4| 7| 4| 4| 6| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 3| 1| 1| 3| 1| 1| 8| 2| 2| 7| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 0| 1| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |             X                                                            |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute, Necrotizing     |                   3              3                                       |      2  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       X                                                                  |      4  2.0|
      Clear Cell Focus                     |    2                                               X                    X|      7  3.0|
      Cyst                                 |                         X                                                |      1     |
      Eosinophilic Focus                   |                2                                                         |      3  2.0|
      Fatty Change                         |                                                                         1|      5  1.2|
      Hematopoietic Cell Proliferation     |             2                    2                                       |      2  2.0|
      Infarct, Multifocal                  |                            4                                   3         |      4  3.3|
      Mixed Cell Focus                     |       3                                                  2               |      3  2.5|
      Necrosis                             |                         2                                                |      2  2.0|
      Regeneration, Diffuse                |                            3                                             |      1  3.0|
      Bile Duct, Hyperplasia               |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +                                          |   3        |
      Inflammation, Suppurative            |                               1                                          |      1  1.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                                        3        1                        |      4  2.0|
      Acinus, Focal Cellular Change        |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute, Necrotizing     |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +        +     +  +     +  +  +           +  +  +  +  +     +     +|  36        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 7| 4| 4| 7| 4| 4| 6| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 3| 1| 1| 3| 1| 1| 8| 2| 2| 7| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 0| 1| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Incisor, Upper, Dysplasia            | 1  2  3        2     1  1     1  1  2           2  1  1  1  1     1     2|     36  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       2                                2                          2     2|      4  2.0|
      Hypertrophy                          |    2     1  1  2  1     4        1  2              2  3           2      |     17  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2                          1           1              2                  |      5  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  I  +  I  +  +  +  +  I  +  M  +  +  +  +  +  +  +  +  +  +|  45        |
      Pars Distalis, Hyperplasia           |             1                 1                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicle, Cyst Multilocular          |                                                 X                        |      1     |
      Follicular Cell, Hyperplasia         |             4                 1                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                           +              +  +            |   5        |
      Inflammation, Chronic Active         |                                           3                              |      1  3.0|
      Duct, Dilatation                     |                                           2              3  3            |      4  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Chronic Active |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                   +           +  +        +                          +   |   9        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +  +     +              +  +  +  +                       +  +   |  22        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 7| 4| 4| 7| 4| 4| 6| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 3| 1| 1| 3| 1| 1| 8| 2| 2| 7| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 0| 1| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis                          |          2  4                       3  3  2                              |     15  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis, Focal                   |             2                                                            |      1  2.0|
      Hematopoietic Cell Proliferation     |             3              3     3                                       |      4  2.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  I  +  +  +  +  M  I  M  +  +  +  +  M  +  +  +  +  +  +  M  M  +|  37        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 1                                                                        |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femur, Fibrosis, Focal               |                               2                                          |      1  2.0|
      Tarsal, Hyperostosis                 | X  X  X  X  X  X  X  X     X  X  X     X  X     X     X     X        X   |     28     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                        3                 1               |      2  2.0|
      Metaplasia, Focal, Squamous          |                                        4                                 |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                                        4                    2           2|     11  2.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Degeneration                         |                                                                          |      1  3.0|
      Cornea, Inflammation, Chronic Active |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 7| 4| 4| 7| 4| 4| 6| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 3| 1| 1| 3| 1| 1| 8| 2| 2| 7| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 0| 1| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +  +     +                 +                                   +      |   9        |
      Hyperplasia                          |    3                          2                                          |      3  2.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    X                                                                     |      1     |
      Hydronephrosis                       |                                                       4                  |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                                                       3                  |      1  3.0|
      Metaplasia, Osseous                  |                                                    2                     |      1  2.0|
      Nephropathy, Chronic                 |    1  1     1  2     1  1     1     1  1  1  1  1  1  1  1  1  1        1|     36  1.1|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Pelvis, Inflammation, Suppurative    | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         | 3                                                                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 5| 6| 5| 0| 5| 5| 6| 6| 6| 6| 7| 6| 7| 7| 3| 7| 8| 8| 3| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                A     +                       M        +           M      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                A     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                A     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                A     +                       +        +           +      |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                A     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                A     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                A     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                A     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                A     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    2                                                                     |             
      Clear Cell Focus                     |          X                    X                                          |             
      Degeneration, Cystic                 |          2                                                              2|             
      Eosinophilic Focus                   |             2                                                            |             
      Fatty Change                         |             2              1                                             |             
      Infarct, Multifocal                  |                4  4  4                       2                       3   |             
      Mixed Cell Focus                     |                                                                          |             
      Centrilobular, Cytomegaly            |          1  1                 2  1              1        1     1        2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Fat, Necrosis                        |                                  3                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                |                A     +                       +        +           +      |             
      Acinus, Atrophy                      |                                              1                           |             
      Acinus, Focal Cellular Change        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +     M                       +        +           +      |             
                                            __________________________________________________________________________|             
   Stomach                                 |                +     +              +        +        +           +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +     +              +        +        +           +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +     +                       +        +           +      |             
      Mineralization                       |                      1                                                   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                +                                                         |             
      Incisor, Upper, Dysplasia            |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +     +                       +        +           +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +     +                       +        +           +      |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                A     +                       +        +           +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 5| 6| 5| 0| 5| 5| 6| 6| 6| 6| 7| 6| 7| 7| 3| 7| 8| 8| 3| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +     +                       +        M           +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +     +                       +        +           +      |             
      Follicle, Cyst Multilocular          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                +     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                         +                                                |             
      Inflammation, Chronic Active         |                         3                                                |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                +     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                            +                                             |             
                                            __________________________________________________________________________|             
   Testes                                  |                +     +                       +        +           +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +     +                       +        +           +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +           +     +  +           +        +     +  +  +  +  +  +     +|             
      Mandibular, Edema                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +           +     +                             +  +  +  +  +        +|             
      Angiectasis                          |                      3                             2     2  3  3        1|             
      Edema                                |    1                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +              +     +        +              +        +           +  +   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                A     M                       +        +           M      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                A                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    |    +           A     +                       +        +           +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +        +     +  +           +        +     +  +  +  +  +  +  +   |             
      Tarsal, Hyperostosis                 | X     X                 X                          X     X  X  X     X   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +     +                       +        +           +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +     +     +           +           +        +           +      |             
      Alveolar Epithelium, Hyperplasia     |          2                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    |                +     +                       +        +           +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 5| 6| 5| 0| 5| 5| 6| 6| 6| 6| 7| 6| 7| 7| 3| 7| 8| 8| 3| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +     +                       +        +           +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                   +      |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
      Degeneration                         |                                                          4               |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +              +     +                       +        +           +  +   |             
      Nephropathy, Chronic                 |                      3                       4                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +     +                       +        +           +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 9| 4| 7| 4| 4| 4| 9| 4| 4| 4| 4| 4| 3| 4| 4| 4| 5| 4| 4| 0| 4| 3| 4| 4|            |
                                           | 6| 1| 1| 5| 1| 1| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 2| 3| 4| 5| 4| 6| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +           +           +     +           +        +     +      |  14        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +     +           +           +     +           +        +     +      |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +           +           +     +           +        +     +      |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +           +           +     +           +        +     +      |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +           +           +     +           +        +     +      |  13        |
      Parasite Metazoan                    | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +           +           +     +           +        +     +      |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     A           +           +     +           +        +     +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     A           +           +     +           +        +     +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     A           +           +     +           +        +     M      |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     A           +           +     +           +        +     +      |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 2                                                                        |      1  2.0|
      Basophilic Focus                     | X                                                              X         |      3  2.0|
      Clear Cell Focus                     |    X              2                 3                 X  2               |      7  2.3|
      Degeneration, Cystic                 |       1                                                                  |      3  1.7|
      Eosinophilic Focus                   |                         3                                                |      2  2.5|
      Fatty Change                         |                                                                          |      2  1.5|
      Infarct, Multifocal                  | 3                                                        2        2      |      8  3.0|
      Mixed Cell Focus                     |                                                 1                        |      1  1.0|
      Centrilobular, Cytomegaly            |       1     2                       2     2     1     1        1     1   |     16  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   2        |
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +           +           +     +           +        +     +      |  13        |
      Acinus, Atrophy                      |                                                                          |      1  1.0|
      Acinus, Focal Cellular Change        | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +           +           +     +           +        +     +      |  13        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +           +           +     +     +     +        +     +      |  16        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +           +           +     +     +     +        +     +      |  16        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +           +           +     +     +     +        +     +      |  15        |
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Incisor, Upper, Dysplasia            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +           +           +     +           +        +     +      |  14        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +           +           +     +           +        +     +      |  14        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 9| 4| 7| 4| 4| 4| 9| 4| 4| 4| 4| 4| 3| 4| 4| 4| 5| 4| 4| 0| 4| 3| 4| 4|            |
                                           | 6| 1| 1| 5| 1| 1| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 2| 3| 4| 5| 4| 6| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +           +           +     +           +        +     +      |  14        |
      Hyperplasia                          |                                                    2                     |      1  2.0|
      Hypertrophy                          |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +           +           +     +           +        +     +      |  14        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +           +           +     +           +        +     +      |  13        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +     +           +           M     +           +        +     +      |  13        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +     A           +           +     +           +        +     +      |  11        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +           +           +     +           +        +     +      |  14        |
      Follicle, Cyst Multilocular          |                      X                                                   |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +           +           +     +           +        +     +      |  14        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +                                                         |   2        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Duct, Dilatation                     |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +     +           +           +     +           +        +     +      |  14        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +           +           +     +           +        +     +      |  14        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +           +           +     +           +        +     +      |  14        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +     +  +  +     +     +     +        +  +     +  +     +  +  +|  30        |
      Mandibular, Edema                    |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +     +  +  +     +           +        +  +     +  +     +  +   |  22        |
      Angiectasis                          |          3     1           2           2        1                    1   |     12  2.0|
      Edema                                |                                                          1               |      2  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +  +  +  +  +     +     +     +           +        +     +      |  21        |
      Hematopoietic Cell Proliferation     |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +     I           +           +     +           M        +     +      |   8        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +     +     +           +     +           +        +     +      |  15        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +     +  +        +     +     +     +     +  +  +  +      |  30        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 9| 4| 7| 4| 4| 4| 9| 4| 4| 4| 4| 4| 3| 4| 4| 4| 5| 4| 4| 0| 4| 3| 4| 4|            |
                                           | 6| 1| 1| 5| 1| 1| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 2| 3| 4| 5| 4| 6| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-0                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Tarsal, Hyperostosis                 | X     X     X  X        X                    X           X     X         |     16     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                        +                                 |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +           +           +     +           +        +     +      |  14        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +           +  +        +     +        +  +        +     +      |  19        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +           +           +     +           +        +     +      |  14        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +           +           +     +           +        +     +      |  14        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                       +|   3        |
      Degeneration                         |                                                                          |      1  4.0|
      Cornea, Inflammation, Chronic Active |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                       +                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +           +           +     +           +        +     +      |  16        |
      Nephropathy, Chronic                 |                      2                                      1            |      4  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +           +           +     +           +        +     M      |  13        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 5| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 8| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3|             
                                           | 4| 5| 4| 4| 4| 5| 5| 3| 5| 5| 6| 6| 4| 6| 6| 6| 6| 7| 4| 7| 7| 6| 7| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    M                 +           +  +     M           +        +     +   |             
      Inflammation, Suppurative            |                                  1                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +        +  +  +        +  +  +  +           +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    A     +           +           +  +     A           +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +           +           +  +  +  +           +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +        +  +  +        +  +     +           +        +     +   |             
      Inflammation, Acute, Necrotizing     |          4                                                               |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X           3                                                  X|             
      Clear Cell Focus                     |                                                                         X|             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |             1              1                                             |             
      Fatty Change                         |                1        1  1              3     1  1                     |             
      Hematopoietic Cell Proliferation     |          2                                                               |             
      Hepatodiaphragmatic Nodule           |                                     X                                    |             
      Infarct, Multifocal                  |    4                                3                                3   |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |       2                                                                  |             
      Mixed Cell Focus                     |                                                                          |             
      Centrilobular, Congestion, Chronic   |                                                                          |             
      Centrilobular, Cytomegaly            |             1              1                    1           2           1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                    +                  |             
      Artery, Inflammation, Chronic Active |                                  2                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                |    A                 +           +  +     +           +        +     +   |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    A                 +           +  +     +           +        +     +   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                  +  +     +                          +   |             
      Incisor, Upper, Dysplasia            |                                  2  1     2                          1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +                 +           +  +     +           +        +     +   |             
      Cardiomyopathy, Chronic Active       |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 5| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 8| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3|             
                                           | 4| 5| 4| 4| 4| 5| 5| 3| 5| 5| 6| 6| 4| 6| 6| 6| 6| 7| 4| 7| 7| 6| 7| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    A                 +           +  +     +           +        +     +   |             
      Hyperplasia                          |                                                                      2   |             
      Hypertrophy                          |                                     1                                    |             
      Necrosis                             |                                                       4                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    A                 +           +  +     +           +        +     +   |             
      Necrosis                             |                                                       4                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    M                 I           +  I     M           M        M     I   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    A                 +           +  +     +           +        +     +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                            +                                             |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Dilatation                     |                            1                                             |             
                                            __________________________________________________________________________|             
   Prostate                                |    +                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                         +|             
                                            __________________________________________________________________________|             
   Testes                                  |    +                 +           +  +     +           +        +     +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    A                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    A     +        +  +  +  +  +  +  +  +  +           +  +  +  +  +  +  +|             
      Mandibular, Angiectasis              |                                                                          |             
      Mandibular, Edema                    |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                   1      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +        +  +  +     +        +                 +  +     +  +  +|             
      Angiectasis                          |                   2  2  1              2                 3  2        2  3|             
      Hyperplasia, Lymphoid                |                                                                   2      |             
                                            __________________________________________________________________________|             
   Spleen                                  |    A  +  +           +           +  +     +  +        +  +     +     +   |             
      Hematopoietic Cell Proliferation     |                                                                      3   |             
                                            __________________________________________________________________________|             
   Thymus                                  |    M                 +           M  +     +           +        +     +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +                 +           +  +     +           +        +     +   |             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +        +  +  +     +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 5| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 8| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3|             
                                           | 4| 5| 4| 4| 4| 5| 5| 3| 5| 5| 6| 6| 4| 6| 6| 6| 6| 7| 4| 7| 7| 6| 7| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Tarsal, Hyperostosis                 | X  X  X  X     X  X           X  X           X  X  X     X     X  X     X|             
      Tarsal, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +                 +           +  +     +           +        +     +   |             
      Compression                          |                                  X                                       |             
      Artery, Inflammation, Chronic Active |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +                 +     +     +  +  +  +           +  +  +  +     +   |             
      Inflammation, Chronic Active         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    |    +                 +           +  +     +           +        +     +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +                 +           +  +     +           +        +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    A        +        +           +  +     +           +        +     +   |             
      Nephropathy, Chronic                 |             2        1           1                    1              2   |             
      Artery, Inflammation, Chronic Active |                                  2                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +                 +           +  +     +           +        +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4|            |
                                           | 4| 8| 8| 1| 1| 1| 1| 2| 2| 2| 2| 3| 2| 3| 3| 3| 4| 8| 4| 4| 4| 9| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                   +              +           +         |  12        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +                                   +              M           A         |   8        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +                 +                 +              +           +         |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                 +                 +              A           +         |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                   +              +           +         |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                   +              +           +         |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +              +              +        +     A           +         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                   +              A           A         |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                   +              A           +         |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +              +              +        +     A           +         |  17        |
      Inflammation, Acute, Necrotizing     |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X                                                                 X      |      5  3.0|
      Clear Cell Focus                     |                            X                                             |      2     |
      Cyst                                 |                                                             X            |      1     |
      Degeneration, Cystic                 |                                                                          |      2  1.0|
      Fatty Change                         |                                                          1               |      7  1.3|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Infarct, Multifocal                  |                   2           2                                          |      5  2.8|
      Inflammation, Chronic                |                      4                                                   |      1  4.0|
      Mineralization                       |                                                                          |      1  2.0|
      Mixed Cell Focus                     |       3                                                                  |      1  3.0|
      Centrilobular, Congestion, Chronic   |                                     4                                    |      1  4.0|
      Centrilobular, Cytomegaly            |                                                                          |      5  1.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                   +        +     A           +         |  11        |
      Acinus, Atrophy                      |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                   +              +           +         |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +                    +     +        +              A           +         |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                    +     +        +              A                     |  11        |
      Epithelium, Hyperplasia              |                      3     3                                             |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                   +              A                     |   9        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                     +                                    |   5        |
      Incisor, Upper, Dysplasia            |                                     1                                    |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4|            |
                                           | 4| 8| 8| 1| 1| 1| 1| 2| 2| 2| 2| 3| 2| 3| 3| 3| 4| 8| 4| 4| 4| 9| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                   +              +           +         |  12        |
      Cardiomyopathy, Chronic Active       |                                     2                                    |      1  2.0|
      Atrium, Thrombosis                   |                                     X                                    |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +                                   +              +           +         |  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +                                   +              +           +         |  11        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy                          |                                     1                                    |      2  1.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +                                   +              +           +         |  11        |
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                   +              A           +         |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                   +              +           +         |  11        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                   +              I           +         |   4        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                   +              +           +         |  11        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +                                   +              +           +         |  12        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +           +        +                                             |   4        |
      Inflammation, Chronic Active         |       2                                                                  |      1  2.0|
      Duct, Dilatation                     |       2           3        3                                             |      4  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +                                   +              +           +         |  12        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +                                   +              +           +         |  12        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                   +              +           +         |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +              +  +  +  +  +        +  +        +  +     +|  32        |
      Mandibular, Angiectasis              |                                                                   4      |      1  4.0|
      Mandibular, Edema                    |       2                                                                  |      1  2.0|
      Mandibular, Hyperplasia, Lymphoid    |             2                                                            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +           +              +  +     +  +           +           +     +|  20        |
      Angiectasis                          |    3                          4  1        2           2           2     3|     15  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4|            |
                                           | 4| 8| 8| 1| 1| 1| 1| 2| 2| 2| 2| 3| 2| 3| 3| 3| 4| 8| 4| 4| 4| 9| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                             +     +  +  +        A           +  +      |  18        |
      Hematopoietic Cell Proliferation     |                               2        3                                 |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M                                   M              +           M         |   7        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                    +              +              +           +         |  13        |
      Cyst Epithelial Inclusion            |                                     X                                    |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +     +  +     +     +  +  +     +  +  +  +   |  40        |
      Tarsal, Hyperostosis                 |    X  X  X  X  X  X  X  X  X     X        X     X     X     X     X  X   |     31     |
      Tarsal, Inflammation, Chronic Active |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                   +              +           +         |  12        |
      Compression                          |                                                                          |      1     |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                             +     +              +           +     +  +|  19        |
      Inflammation, Chronic Active         | 4                                   3                                    |      3  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                   +              +           +         |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                   +              +           +         |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +                                                                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                   +              +           +         |  12        |
      Nephropathy, Chronic                 |                                                                2         |      6  1.5|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                   +              +           +         |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 8| 2| 3| 3| 3| 1|             
                                           | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 2| 6| 6| 6| 8| 7| 7| 7| 5| 9| 7| 8| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |             +           +        A           +           +              +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +           +        A           +           +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +           +        A           +           +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +           +        A           +           +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +           +        A           +           +              +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Clear Cell Focus                     |                      X     X                                         2   |             
      Degeneration, Cystic                 |                   1  3     2                                         1   |             
      Eosinophilic Focus                   |                                                                          |             
      Fibrosis, Focal                      |                                                                      3   |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Infarct, Multifocal                  | 2     4                          4                             2        2|             
      Mixed Cell Focus                     |                2                                                         |             
      Centrilobular, Cytomegaly            |       2  2     1  2  3     2  2     1  1  2     1  1  1        2  1  3  1|             
                                            __________________________________________________________________________|             
   Pancreas                                |             +           +        A           +           +              +|             
      Acinus, Atrophy                      |                                                                          |             
      Artery, Inflammation, Chronic Active |                         2                                                |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Stomach                                 |             +  +  +  +  +        A           +           +           +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +  +  +  +  +        A           +           +           +  +|             
      Diverticulum                         |                                                                          |             
      Hyperplasia, Squamous                |                   2  2                                               2   |             
      Epithelium, Hyperplasia              |                2                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +     +  +  +        A           +           +           +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Incisor, Upper, Dysplasia            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +           +        +           +           +              +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +           +        A           +           +              +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +           +        A           +           +              +|             
      Hypertrophy                          |             2           3                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +           +        A           +           +              +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +           +        A           +           +              +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +           +        +           +           +              +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 8| 2| 3| 3| 3| 1|             
                                           | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 2| 6| 6| 6| 8| 7| 7| 7| 5| 9| 7| 8| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +           +        +           +           +              +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Testes                                  |             +           +        +           +           +              +|             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +  +  +     +        +  +        +     +  +  +     +        +|             
      Deep Cervical, Edema                 |                                                    3                     |             
      Mandibular, Angiectasis              | 3                                                                        |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +        +  +  +  +                 +                 +        +         |             
      Angiectasis                          | 2              3  3                 2                 1        2         |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |          2                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +     +           +     +  A  +        +           +              +|             
      Hematopoietic Cell Proliferation     |       2                                                                  |             
      Hyperplasia, Lymphoid                |                                     2                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +           M        M           +           +              M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |             +           +        +           +           +           +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +  +     +  +  +     +  +  +  +  +  +     +     +           +  +|             
      Tarsal, Hyperostosis                 | X        X        X  X        X     X  X  X  X     X                 X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +           +        +           +           +              +|             
      Hemorrhage                           |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +           +           +        +  +  +     +           +              +|             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 2           2                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 8| 2| 3| 3| 3| 1|             
                                           | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 2| 6| 6| 6| 8| 7| 7| 7| 5| 9| 7| 8| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |             +           +        +           +           +              +|             
                                            __________________________________________________________________________|             
   Trachea                                 |             +           +        +           +           +              +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +           +        A           +           +              +|             
      Nephropathy, Chronic                 |                         1                                1              1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +           +        +           +           +              +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 6| 4| 4| 7| 3| 4| 8| 4| 4| 4| 4|            |
                                           | 8| 8| 3| 4| 1| 1| 1| 1| 2| 2| 0| 2| 2| 3| 0| 3| 3| 4| 2| 3| 8| 4| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +                    +           +        +  +     +            |  13        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       A  +                    +           +        +  +     +            |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +  +                    +           +        +  +     +            |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       A  +                    +           +        +  +     +            |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +                    +           +        +  +     +            |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       A  +                    +           +        +  +     +            |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       A  +                    +           +        A  +     +           +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       A  +                    +           +        A  +     +            |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       A  +                    +           +        A  +     +           +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       A  +                    +           +        A  +     +            |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Clear Cell Focus                     |                                                                          |      3  2.0|
      Degeneration, Cystic                 |                   1                       1  2  1        2               |      9  1.6|
      Eosinophilic Focus                   |                   3                                               2  3   |      3  2.7|
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                                                                   X      |      1     |
      Infarct, Multifocal                  | 2  3           1              2        3              3                  |     11  2.5|
      Mixed Cell Focus                     | 3                                                                        |      2  2.5|
      Centrilobular, Cytomegaly            |          2     2  1  2  1  2     2  2     1  2  2  2     3     2  2  2   |     33  1.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +                    +           +        +  +     +  +         |  13        |
      Acinus, Atrophy                      |                                                                4         |      1  4.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Duct, Dilatation                     |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +                    +           +        +  +     +            |  13        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +  +  +                 +           +  +     +  +     +            |  18        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +  +                 +           +  +     +  +     +            |  18        |
      Diverticulum                         |                               2                                          |      1  2.0|
      Hyperplasia, Squamous                |             2                                                            |      4  2.0|
      Epithelium, Hyperplasia              |                                              2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +  +                 +           +        +  +     +            |  16        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |          +                                                               |   1        |
      Incisor, Upper, Dysplasia            |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +                    +           +        +  +     +            |  13        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +  +                    +           +        +  +     +            |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +  +                    +           +        +  +     +            |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 6| 4| 4| 7| 3| 4| 8| 4| 4| 4| 4|            |
                                           | 8| 8| 3| 4| 1| 1| 1| 1| 2| 2| 0| 2| 2| 3| 0| 3| 3| 4| 2| 3| 8| 4| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hypertrophy                          |          3                                            2                  |      4  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +  +                    +           M        +  +     +            |  11        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +                    +           +        +  +     +            |  12        |
      Hyperplasia                          |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +  +                    +           +        +  +     +            |  13        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +                    +           M        I  I     +            |  10        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +                    +           +        +  +     +            |  13        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +  +                    +           +        +  +     +            |  13        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                     +     +                              |   2        |
      Duct, Dilatation                     |                                     3     4                              |      2  3.5|
                                            __________________________________________________________________________|____________|
   Prostate                                |       +  +                    +           +        +  +     +            |  13        |
                                            __________________________________________________________________________|____________|
   Testes                                  |       +  +                    +           +        +  +     +            |  13        |
      Degeneration                         |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +                    +           +        +  +     +            |  13        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +              +     +           +  +     +  +  +  +  +        +|  27        |
      Deep Cervical, Edema                 |                                                                          |      1  3.0|
      Mandibular, Angiectasis              |                                                                          |      1  3.0|
      Mandibular, Hyperplasia, Lymphoid    |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                         +     +           +  +     +        +  +        +|  16        |
      Angiectasis                          |                                           1  3     2        2  2         |     11  2.1|
      Edema                                |                                                    3                     |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +              +  +  +  +        +        +  +     +           +|  20        |
      Hematopoietic Cell Proliferation     | 2                                         3                              |      3  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       M  M                    M           +        +  +     +            |   7        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +                    +           +        +  +     +            |  14        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +                    +     +  +  +  +     +  +     +  +        +|  30        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 6| 4| 4| 7| 3| 4| 8| 4| 4| 4| 4|            |
                                           | 8| 8| 3| 4| 1| 1| 1| 1| 2| 2| 0| 2| 2| 3| 0| 3| 3| 4| 2| 3| 8| 4| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Tarsal, Hyperostosis                 | X  X     X                          X  X     X                 X        X|     19     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +                    +           +        +  +     +            |  13        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +     +     +        +           +     +  +  +  +  +            |  21        |
      Inflammation, Chronic Active         |          2     1                                            2            |      3  1.7|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +                    +           +        +  +     +            |  13        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +                    +           +        +  +     +            |  13        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                          +           +   |   2        |
      Degeneration                         |                                                          3           3   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                          +           +   |   2        |
      Inflammation, Suppurative            |                                                          4               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +                    +           +        +  +     +            |  13        |
      Nephropathy, Chronic                 |          1                                                               |      4  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +                    +           +        +  +     +            |  13        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8| 3| 3| 4| 3| 3| 3| 3| 1| 2| 3| 3| 3| 8|             
                                           | 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 0| 6| 6| 3| 6| 7| 7| 7| 3| 0| 7| 8| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +                 M              I        +              A  M        +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M                 +              +        +              +  +        +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +                 +              +        +              +  +        +  +|             
      Hyperplasia, Atypical                |                                                             4            |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | M                 A              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +                 +              +        +              +  +        +  +|             
      Inflammation, Acute, Necrotizing     |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                               X              X  X                        |             
      Cyst                                 |    X                                                                     |             
      Degeneration, Cystic                 |       1        3                             2  2  1                     |             
      Eosinophilic Focus                   |          3                                                               |             
      Fatty Change                         |                2                             1  1                        |             
      Infarct, Multifocal                  |                                  3     1                    3           4|             
      Bile Duct, Hyperplasia               |                               2                                          |             
      Centrilobular, Cytomegaly            |       1        3     1  1  2  3              3  3  3  2           2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                    +               |             
      Inflammation, Suppurative            |                                     3                    3               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +                 +              +  +     +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +                                +  +     +                 +        +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +                                +        +                 +        +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                           +                              |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Incisor, Upper, Dysplasia            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +                 +              +        +              +  +        +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +                 +              +        +              +  +        +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                 +              +        +              +  +        +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8| 3| 3| 4| 3| 3| 3| 3| 1| 2| 3| 3| 3| 8|             
                                           | 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 0| 6| 6| 3| 6| 7| 7| 7| 3| 0| 7| 8| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +                 +              +        +              I  +        +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +                 +              +        +              +  +        +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +                                                               |             
      Inflammation, Chronic Active         |          3                                                               |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +                 +              +        +              +  +        +  +|             
      Degeneration                         |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +                 +              +        +              +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | M  +  +        +  +           +  +     +  +              +  +  +  +  +  +|             
      Mandibular, Angiectasis              |                                                             2            |             
      Mandibular, Edema                    |    2  1                                                                  |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +        +              +        +                 +     +  +      |             
      Angiectasis                          |       2        2              2                          2               |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +              +  +           +     +  +              +  +  +     +  +|             
      Hematopoietic Cell Proliferation     |    2                             2                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | M                 +              I        +              +  M        +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +              +              +        +              +  +  +     +  +|             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +           +     +     +  +        +  +  +        +  +  +  +  +  +|             
      Tarsal, Hyperostosis                 |    X  X                 X     X              X  X              X  X     X|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                 +              +     +  +              +  +        +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8| 3| 3| 4| 3| 3| 3| 3| 1| 2| 3| 3| 3| 8|             
                                           | 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 0| 6| 6| 3| 6| 7| 7| 7| 3| 0| 7| 8| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +                 +           +  +        +  +        +  +  +        +  +|             
      Alveolar Epithelium, Hyperplasia     |                                              2                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +                 +              +        +              +  +        +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +                 +              +        +              +  +        +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                             +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +                 +              +        +              +  +        +  +|             
      Nephropathy, Chronic                 |                                                          1           1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +        +              +        +              +  +        +  +|             
      Inflammation, Chronic Active         | 1        3                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 5| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 6| 2| 4| 4| 7| 4| 6| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 3| 6| 6| 4|            |
                                           | 8| 8| 8| 1| 6| 3| 9| 1| 3| 1| 0| 1| 2| 2| 2| 2| 3| 7| 3| 3| 3| 2| 0| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |             +     +     +  +  +                    M           +  +  M   |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                   +     +  +  +                    +           +  +  +   |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                   +     +  +  +                    M           +  +  +   |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                   +     +  +  +                    +           +  +  +   |  15        |
      Parasite Metazoan                    |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                   A     +  +  +                    +           +  +  +   |  15        |
      Hyperplasia, Atypical                |                                                                          |      1  4.0|
      Inflammation, Acute, Necrotizing     |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                   +     +  +  +                    +           +  +  +   |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                   +     +  +  +                    +           +  +  +   |  16        |
      Inflammation, Acute, Necrotizing     |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       2                                                                  |      1  2.0|
      Clear Cell Focus                     |                                                    X                     |      4     |
      Cyst                                 |                                                                          |      1     |
      Degeneration, Cystic                 |                2     2                                                   |      7  1.9|
      Eosinophilic Focus                   |                                                    X        2            |      3  2.5|
      Fatty Change                         |                                                    1                     |      4  1.3|
      Infarct, Multifocal                  |                   3  2        3                                          |      7  2.7|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
      Centrilobular, Cytomegaly            | 1        1           3           2  2  2        1  3                    1|     20  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   3        |
      Inflammation, Suppurative            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |             +     +     +  +  +                 +  +           +  +  +   |  19        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                         +  +  +                 +  +           +  +  +   |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                         +  +  +                    +           +  +  +   |  13        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                   +                                +                     |   2        |
      Incisor, Upper, Dysplasia            |                   2                                4                     |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +     +     +  +  +                    +           +  +  +   |  17        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 5| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 6| 2| 4| 4| 7| 4| 6| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 3| 6| 6| 4|            |
                                           | 8| 8| 8| 1| 6| 3| 9| 1| 3| 1| 0| 1| 2| 2| 2| 2| 3| 7| 3| 3| 3| 2| 0| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |             +     +     +  +  +                    +           +  +  +   |  17        |
      Hyperplasia                          |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +     +     +  +  +                    +           +  +  +   |  17        |
      Hyperplasia                          |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |             M     +     +  +  +                    +           +  +  M   |  14        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |             +     +     +  +  +                    +           +  +  +   |  17        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +                          +                                    |   3        |
      Inflammation, Chronic Active         |          1                                                               |      2  2.0|
      Duct, Dilatation                     |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +                                                        +      |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  |             +     +     +  +  +                    +           +  +  +   |  17        |
      Degeneration                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +     +     +  +  +                    +           +  +  +   |  18        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +        +  +  +  +     +  +  +        +        +  +  +  +     +  +  +  +|  31        |
      Mandibular, Angiectasis              |                                                                          |      1  2.0|
      Mandibular, Edema                    |                                                                          |      2  1.5|
      Mandibular, Hyperplasia, Lymphoid    |                                                    2  2                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                        +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +        +     +  +        +           +        +  +  +  +     +     +  +|  20        |
      Angiectasis                          | 3        3                                            2  2           2   |      9  2.2|
      Hyperplasia, Lymphoid                |                                        3           2                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  |             +     +     +  +  +        +           +  +  +     +  +  +  +|  25        |
      Hematopoietic Cell Proliferation     |                            4                                      2      |      4  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |             +     +     M  M  +                    +           +  M  +   |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +     +     +     +  +  +                    +           +  +  +   |  20        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 5| 7|            |
                             DAY ON TEST   | 3| 3| 3| 4| 6| 2| 4| 4| 7| 4| 6| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 3| 6| 6| 4|            |
                                           | 8| 8| 8| 1| 6| 3| 9| 1| 3| 1| 0| 1| 2| 2| 2| 2| 3| 7| 3| 3| 3| 2| 0| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Fibrosis        |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +     +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  37        |
      Tarsal, Hyperostosis                 |    X  X  X                       X  X  X     X  X  X  X  X  X           X|     22     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +     +     +  +  +                    +           +  +  +   |  18        |
      Hemorrhage                           |                   3                                                      |      1  3.0|
      Hydrocephalus                        |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |             +     +     +  +  +                    +           +  +  +   |  20        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |             +     +     +  +  +                    +           +  +  +   |  17        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +     +     +  +  +                    +           +  +  +   |  17        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                              +                           |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +        +     +     +  +  +                    +           +  +  +   |  18        |
      Nephropathy, Chronic                 |             1           1     1                                1  3  2   |      9  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +     +     +  +  +                    +           +  +  +   |  18        |
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 2| 8| 3| 3|             
                                           | 4| 4| 4| 4| 2| 5| 5| 5| 9| 5| 6| 6| 2| 6| 6| 7| 7| 0| 7| 7| 8| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +           +           +              +              +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             |             +           M           A              M              +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +        +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +        +           +           A              +              +      |             
      Prolapse                             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +     +     +           A        +     +              +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +           +           A              A              +      |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +     +     +           A        +     +              +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Basophilic Focus                     |                2        X     X                    2                 X   |             
      Clear Cell Focus                     |       2  X                             X                                 |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Cyst                                 |                            X                                             |             
      Degeneration, Cystic                 |          2     2           2                 1                           |             
      Eosinophilic Focus                   |                               X  X                                       |             
      Fatty Change                         |          2                                                               |             
      Infarct, Multifocal                  |                                     4                                   3|             
      Mixed Cell Focus                     |          X                                                               |             
      Necrosis, Multifocal                 |                         2                                                |             
      Centrilobular, Cytomegaly            |       1  3  2  2  1  2     2                 2  2        1           1   |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +           +           A     +        +              +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +           +           A     +        +              +      |             
      Hyperplasia, Squamous                |                                           3                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +           +           A     +        +              +      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Incisor, Upper, Dysplasia            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +           +           +              +              +      |             
      Bacterium                            |             X                                                            |             
      Cardiomyopathy, Chronic Active       |                         2                                                |             
      Valve, Inflammation, Suppurative     |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +           +           A              +              +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 2| 8| 3| 3|             
                                           | 4| 4| 4| 4| 2| 5| 5| 5| 9| 5| 6| 6| 2| 6| 6| 7| 7| 0| 7| 7| 8| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             M           M           +              +              +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +           M           A              +              +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +           +           +              +              +      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                      +                    +           +     +            |             
      Inflammation, Chronic Active         |                                                             2            |             
      Duct, Dilatation                     |                      2                    3           1                  |             
                                            __________________________________________________________________________|             
   Prostate                                |             +           +           A              +              +      |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                             +            |             
      Inflammation, Chronic Active         |                                                             2            |             
                                            __________________________________________________________________________|             
   Testes                                  |             +           +           A              +              +      |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +           +           A              +              +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           M  +        +        +  A     +        +  +     +     +     +|             
      Lumbar, Edema                        |                                                                          |             
      Renal, Edema                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +              +        +        +                                      +|             
      Angiectasis                          |                2                 2                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +        +     +  +  +           A  +     +  +  +              +      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                      3                          3                        |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +           +           A              M              +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |             +           +           +              +              +      |             
      Inflammation, Acute                  |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +  +  +  +     +     +     +  +     +     +  +  +  +     +     +|             
      Tarsal, Hyperostosis                 |          X     X  X           X        X     X        X  X  X           X|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +           +           +              +              +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +           +  +     +  +     +     +  +           +  +           +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 2| 8| 3| 3|             
                                           | 4| 4| 4| 4| 2| 5| 5| 5| 9| 5| 6| 6| 2| 6| 6| 7| 7| 0| 7| 7| 8| 9| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                        2                                 |             
                                            __________________________________________________________________________|             
   Nose                                    |             +           +           +              +              +      |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +           +           +              +              +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
      Degeneration                         |                                  2                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +        +                       +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +           +           A              +              +      |             
      Nephropathy, Chronic                 |                                                                          |             
      Pelvis, Inflammation, Suppurative    |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +           +           A              +              +      |             
      Inflammation, Chronic Active         |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 4| 4| 3| 7| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9|            |
                                           | 8| 1| 1| 3| 8| 1| 3| 1| 2| 2| 2| 2| 3| 3| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  +     +                       +                             +|  10        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          M  A     +                       +                             +|   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +  A     +                       +                             +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +  A                             +                             +|   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  A                             +                             +|   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +  A                             +                             +|   8        |
      Prolapse                             |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +  A     +                       +     +                       +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +  A                             +     +                       +|   7        |
      Inflammation, Chronic Active         |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +  A                             M                             +|   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  A                             A                             +|   8        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                                          X               |      6  2.0|
      Clear Cell Focus                     |                      X                                               X   |      5  2.0|
      Clear Cell Focus, Multiple           |                                     3                                    |      1  3.0|
      Cyst                                 |    X                                                                     |      2     |
      Degeneration, Cystic                 |                2                    2              2        1        1   |      9  1.7|
      Eosinophilic Focus                   |                               1     2                          3         |      5  2.0|
      Fatty Change                         |                                        1                                 |      2  1.5|
      Infarct, Multifocal                  |          4                                4        2                    3|      6  3.3|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis, Multifocal                 |                                                                          |      1  2.0|
      Centrilobular, Cytomegaly            |       2        2                 2  3              1        2  2     3   |     19  1.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +  A     +                       +                             +|   8        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +     +                       +                             +|   9        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +  +     +                       +                             +|  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +  +                             +                             +|   9        |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +  +                             +                             +|   9        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |          +                                +                              |   2        |
      Incisor, Upper, Dysplasia            |          1                                2                              |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +     +                       +                             +|  10        |
      Bacterium                            |                                                                          |      1     |
      Cardiomyopathy, Chronic Active       |                                                                          |      1  2.0|
      Valve, Inflammation, Suppurative     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 4| 4| 3| 7| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9|            |
                                           | 8| 1| 1| 3| 8| 1| 3| 1| 2| 2| 2| 2| 3| 3| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |          +  +     +                       +                             +|   9        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +  +     +                       +                             +|   9        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +  +     +                       +                             +|   9        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +  A     +                       +                             +|   8        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +  +     +                       +                             +|   8        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +  +     +                       +                             M|   7        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +  A     +                       +                             +|   9        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +  +     +                       +                             +|   9        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                               +           +                    +        +|   8        |
      Inflammation, Chronic Active         |                                           3                    4         |      3  3.0|
      Duct, Dilatation                     |                                                                         3|      4  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                |          +  +     +                       +                             +|   9        |
      Inflammation, Suppurative            |             3     3                                                      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |          +  +     +                       +                             +|   9        |
      Inflammation, Acute, Necrotizing     |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +     +                       +                             +|   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +  +  +                       +     +     +  +  +  +        +|  23        |
      Lumbar, Edema                        |                   2                                                      |      1  2.0|
      Renal, Edema                         |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +           +                          +     +     +  +  +  +        +|  15        |
      Angiectasis                          | 3              1                          4     4     3  3  2  3        4|     11  2.8|
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +  A     +  +                 +  +                 +           +|  17        |
      Hematopoietic Cell Proliferation     |                                           3                              |      1  3.0|
      Hyperplasia, Lymphoid                |                      2                                                   |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          M  +     +                       +                             +|   7        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +  +     +                       M                             +|   9        |
      Inflammation, Acute                  |                   4                                                      |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 4| 4| 3| 7| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9|            |
                                           | 8| 1| 1| 3| 8| 1| 3| 1| 2| 2| 2| 2| 3| 3| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +           +|  35        |
      Tarsal, Hyperostosis                 | X  X        X        X  X  X  X  X  X  X  X  X  X  X  X  X  X            |     27     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +     +                       +                             +|  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +  +  +  +                    +  +     +           +     +     +|  22        |
      Alveolar Epithelium, Hyperplasia     |                                        3                                 |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    |          +  +     +                       +                             +|  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +  +     +                       +                             +|  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                            +                        |   3        |
      Degeneration                         |    2                                            1                        |      3  1.7|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                                                                     |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +  +     +                       +                             +|   9        |
      Nephropathy, Chronic                 |          3                                                               |      1  3.0|
      Pelvis, Inflammation, Suppurative    |             1     1                                                      |      2  1.0|
      Renal Tubule, Hyperplasia            |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +  A     +                       +                             +|   8        |
      Inflammation, Chronic Active         |                   3                                                      |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    300 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X                       X               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Necrotizing     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            1                                             |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |    X     X  X  2     X        2  2  X  X  X     3  X              X     X|             
      Degeneration, Cystic                 |    1     2  2  2  2  1        1  2  2  2  2  2  2  2  2  2  1  2  3     2|             
      Eosinophilic Focus                   |                1     2     2        3           3                        |             
      Infarct, Multifocal                  |                               3                                          |             
      Inflammation, Chronic                |             3                                                            |             
      Mixed Cell Focus                     |                   3                          2                           |             
      Centrilobular, Cytomegaly            | 1  1  1  3  3  2  2  2  2  2  1  3  2  2  2  2  3  3  2  2  1  2  3     2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                      4           1           2              3            |             
      Acinus, Depletion Secretory          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                   2                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Incisor, Upper, Dysplasia            | 1  2  1  2  2  1  1  1  1  2  1  2  1  2  1  1  1  2     1  2  1  2  1  1|             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    300 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |          1  2  2           2     2        2  2                       1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     3                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  I  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  I  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                                             2  1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                             +            |             
      Duct, Dilatation                     |                                                             3            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          +                                               +               |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Thrombosis                  |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Angiectasis              |                                     2                                    |             
      Mandibular, Edema                    |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +     +              +  +           +              +     +         |             
      Angiectasis                          |             3              3  3           2                    2         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tarsal, Hyperostosis                 |    X                             X  X              X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    300 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |             1                                            1               |             
      Inflammation, Chronic Active         |                                                       3                  |             
      Alveolar Epithelium, Hyperplasia     |                      2                                                   |             
      Artery, Mediastinum, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
      Degeneration                         |                3                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                   +                     |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  1  2  1  1  1     1  1  1  2  1        1  1  1     2     1  1  1  1  1|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 8| 4| 4| 4| 6| 4| 4| 4| 4| 1| 4| 7| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 1| 1| 0| 1| 1| 1| 4| 2| 2| 2| 2| 0| 2| 8| 8| 3| 3| 3| 3| 3| 1| 4| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    300 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  +  +  +  M  +  +  +  M  +  A  A  +  +  +  +  +  +  +  +  +  M|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute, Necrotizing     | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Parasite Metazoan                    |                                                                         X|      1     |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                           X                              |      1     |
      Clear Cell Focus                     | X  X        X        X  X  X        X        X  X  X  X           X      |     26  2.3|
      Degeneration, Cystic                 | 2  2  2  2  2  2     3  3  3  3     3        2  2  3  3  3        3  2  3|     39  2.2|
      Eosinophilic Focus                   |                                                                          |      5  2.2|
      Infarct, Multifocal                  |                                  3                          4            |      3  3.3|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Mixed Cell Focus                     |                                                                   4      |      3  3.0|
      Centrilobular, Cytomegaly            | 2  2  1  3  2  1  1  3  4  2  3     3        2  3  3  4  2  2  1  3  2  3|     46  2.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                 +  +                              |   3        |
      Artery, Inflammation, Chronic Active |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      | 1                                                     1                  |      6  2.0|
      Acinus, Depletion Secretory          |                                  X                                       |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer                                |                   1                                                      |      1  1.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +        +  +  +  +  +  +  +  +     +  +  +     +  +  +  +     +  +  +  +|  44        |
      Incisor, Upper, Dysplasia            | 1        2  1  2  1  1  1  2  1     1  1  1     2  1  1  1     1  1  1  2|     44  1.3|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 8| 4| 4| 4| 6| 4| 4| 4| 4| 1| 4| 7| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 1| 1| 0| 1| 1| 1| 4| 2| 2| 2| 2| 0| 2| 8| 8| 3| 3| 3| 3| 3| 1| 4| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    300 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Chronic Active |                      1                                                   |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |             2              1                                             |      2  1.5|
      Hypertrophy                          | 3        1  1              2     1  1                 1                  |     15  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  M  I  +  +  +  M  +  +  M  +  M  +  I  M  +  +  +  I  +  +  M  +  +  M|  34        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         |             1                                               2            |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                    +                       +                           |   4        |
      Duct, Dilatation                     | 2                    2                       1                           |      4  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Thrombosis                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mandibular, Angiectasis              |                                                                          |      1  2.0|
      Mandibular, Edema                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +                          +  +  +  +  +  +  +  +        +         |  18        |
      Angiectasis                          | 2     3                          4           2  1  2  1        3         |     13  2.4|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Depletion Lymphoid                   |                   2                                                      |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 8| 4| 4| 4| 6| 4| 4| 4| 4| 1| 4| 7| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 1| 1| 0| 1| 1| 1| 4| 2| 2| 2| 2| 0| 2| 8| 8| 3| 3| 3| 3| 3| 1| 4| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    300 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |       3                          3                                       |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  M  +  M  M  +  +  +  +  +  M  +  +  +  +|  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Tarsal, Hyperostosis                 | X        X     X                             X           X               |      9     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      2  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Artery, Mediastinum, Inflammation,   |                                                                          |            |
           Chronic Active                  |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   2        |
      Degeneration                         |             3                                                            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                 +                                          |   4        |
      Hyperplasia                          |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 1  3  2     1  2     1  1  1  1     1        1  1  1  1  1  2  1     1  2|     39  1.2|
      Artery, Inflammation, Chronic Active |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  93                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 0| 0| 0| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 1| 4| 4| 4| 8| 4| 4| 1| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    300 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Necrotizing     |                      2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Necrotizing     |                      2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      X                                1                  |             
      Clear Cell Focus                     |                2  1                 3  X     2  2  X  X     X        X  3|             
      Degeneration, Cystic                 |                3  2           2     2  1     3  2  2  2  2  2     2     2|             
      Eosinophilic Focus                   |                                                             X            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct, Multifocal                  |                                                                          |             
      Inflammation, Chronic                |                                           2                              |             
      Centrilobular, Cytomegaly            |                3  1  2     2  3     3  2  2  3  2  2  2  2  3  2  2  1  3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Focal Cellular Change        |                                                 X                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
      Necrosis                             |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Necrotizing     | 3     2  3                 1                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   |                +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Incisor, Upper, Dysplasia            |                1           2  2     1  1  2  3  2  1  2  2  2  2  1  1  1|             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  I  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 0| 0| 0| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 1| 4| 4| 4| 8| 4| 4| 1| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    300 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                              1           1     2     2  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  I  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  I  +  +  +  +  +  +  +  +  +  I  M  +  +  +  M  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Follicle, Cyst Multilocular          |                                                                          |             
      Follicular Cell, Hyperplasia         |                   2                                   1              1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +     +                       +           +     +         |             
      Inflammation, Chronic Active         |                1     3                                                   |             
      Duct, Dilatation                     |                4     3                       3           2     3         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                      2                                                   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Mediastinal, Angiectasis             |                                                                4         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +     +  +     +                       +  +  +     +|             
      Angiectasis                          |                4  4  4     3  3     2                       1  3        2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 0| 0| 0| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 1| 4| 4| 4| 8| 4| 4| 1| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    300 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Femur, Hyperostosis                  |                                           X                              |             
      Tarsal, Hyperostosis                 |                X  X           X     X  X  X     X  X              X      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                       2                  |             
      Alveolar Epithelium, Hyperplasia     |                                     1                 3     2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                    +     +      |             
      Hyperplasia                          |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus Bacterial                    |                                                                          |             
      Nephropathy, Chronic                 |                   2        1  1     1  1  1  1  1  2  1  1  1  1  1  1  1|             
      Pelvis, Inflammation, Suppurative    |                      2                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                                                          |             
      Inflammation, Chronic Active         |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 2| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 4| 3| 9| 1| 3| 4| 4| 4| 4| 4| 4| 4| 5| 4| 1| 4| 3| 4| 2| 4| 4| 4| 4|            |
                                           | 7| 8| 4| 8| 9| 2| 8| 1| 1| 1| 1| 2| 2| 2| 1| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    300 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute, Necrotizing     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                              X                           |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Acute, Necrotizing     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                                          X               |      3  1.0|
      Clear Cell Focus                     |    X                 X           X     X                 X     X  X  X  X|     20  2.2|
      Degeneration, Cystic                 |    2     2     2  3  2  2     1  3  2        2     2     1     3  3  3  2|     29  2.1|
      Eosinophilic Focus                   |                                                          2               |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                             2            |      1  2.0|
      Infarct, Multifocal                  | 2                                               2                        |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Centrilobular, Cytomegaly            |    2     1     3  3  3  2  2  2  3  3  1     2     3     2  1  3  3  3  2|     37  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                               +     +                  |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Focal Cellular Change        |                                                                      X   |      2     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Granulomatous          |                4                                                         |      1  4.0|
      Necrosis                             |                2                                                         |      1  2.0|
      Acinus, Atrophy                      |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|  48        |
      Epithelium, Hyperplasia              |                         3                                1               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|  47        |
      Inflammation, Acute, Necrotizing     |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +     +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  39        |
      Incisor, Upper, Dysplasia            | 1  3     2     1  1  1  1  1  2  1  1  1     1  1  1  1  2  1  2  2  1  1|     38  1.4|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 2| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 4| 3| 9| 1| 3| 4| 4| 4| 4| 4| 4| 4| 5| 4| 1| 4| 3| 4| 2| 4| 4| 4| 4|            |
                                           | 7| 8| 4| 8| 9| 2| 8| 1| 1| 1| 1| 2| 2| 2| 1| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    300 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                         1                    1           2     1         |      4  1.3|
      Hypertrophy                          |                      1                 2                                 |      7  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  I  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  M  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | I  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                          2               |      1  2.0|
      Follicle, Cyst Multilocular          |                                           X                              |      1     |
      Follicular Cell, Hyperplasia         |                                                 1        3              1|      6  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +                 +                                   +               |   8        |
      Inflammation, Chronic Active         |    4                                                                     |      3  2.7|
      Duct, Dilatation                     |                      2                                   2               |      7  2.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |       3     3                                                            |      3  2.7|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Mediastinal, Angiectasis             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                             +            |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +                       +     +     +        +     +  +  +        +   |  24        |
      Angiectasis                          |    3                                   2                 3           3   |     13  2.8|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                       X                  |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05075-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 07:40:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 2| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 4| 3| 9| 1| 3| 4| 4| 4| 4| 4| 4| 4| 5| 4| 1| 4| 3| 4| 2| 4| 4| 4| 4|            |
                                           | 7| 8| 4| 8| 9| 2| 8| 1| 1| 1| 1| 2| 2| 2| 1| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    300 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |       4                                                     3            |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  41        |
      Atrophy                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 3                                                                        |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femur, Hyperostosis                  |                                                                          |      1     |
      Tarsal, Hyperostosis                 |    X     X                                               X  X            |     13     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                             3            |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |          1     2                                                  2      |      6  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Inflammation, Suppurative    |                                           4                              |      1  4.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                             +            |   1        |
      Degeneration                         |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                             +        +   |   5        |
      Hyperplasia                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Embolus Bacterial                    |       X                                                                  |      1     |
      Nephropathy, Chronic                 |    1     2     1  1  1  1     1  1  1  1  1  1     1     1  1  1  1  1  1|     35  1.1|
      Pelvis, Inflammation, Suppurative    |       3                                                                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Concretion                           |             2                                                            |      1  2.0|
      Inflammation, Chronic Active         |       3     3           4     3                                          |      5  3.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.