Share This:
https://ntp.niehs.nih.gov/go/2131

TDMS Study 05075-02 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/09/94   
EXP: 05075                    DIPHENYLHYDANTOIN                TIME: 16:10:05   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 55765    
CONT: NO1-ES-82151                                             CAS: 57-41-0     
PATHOLOGIST: S. GRUMBEIN                     S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/09/94  
EXP: 05075                    DIPHENYLHYDANTOIN                TIME: 16:10:05  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 55765   
CONT: NO1-ES-82151                                             CAS: 57-41-0    
PATHOLOGIST: S. GRUMBEIN                     S. EUSTIS                         

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM   0-0                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 11     CENSORED DEATHS 0    TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      463   540   609   639   650   667   673   678   678   680                 |
 |      683                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = O PPM    10-0                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 0    TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      491   575   576   605   633   633   633   642   646   652                 |
 |      696   716   720                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 30 PPM   1-1                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 11     CENSORED DEATHS 0    TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      495   506   546   548   574   584   586   602   669   705                 |
 |      713                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 100 PPM  10-3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 1    TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      585   585   617   632   632   633   660   660   674   678                 |
 |      688   704   725                                                           |
 |  CENSORED DEATHS                                                               |
 |      429                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 100 PPM  3-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      223   481   535   564   566   573   632   643   645   649                 |
 |      660   660   680   697   713   720   723                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 100 PPM  0-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 9      CENSORED DEATHS 1    TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      303   412   422   589   590   633   639   678   693                       |
 |  CENSORED DEATHS                                                               |
 |      429                                                                       |
 |                                                                                |
 ==================================================================================

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 300 PPM  10-10                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 6      CENSORED DEATHS 0    TERMINAL 44        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      564   641   678   680   710   718                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 300 PPM  0-10                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      31    31    31    31    31    31    99    244   408   612                 |
 |      633   644   651   707   712   723                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 734 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   734 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM   0-0|   100.0 100.0 100.0 100.0 100.0  98.0  96.0  96.0  90.0  78.0      |
 |           |                                                                    |
 |           |                                                                    |
 |O          |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  92.0  80.0  74.0      |
 |PPM    10-0|                                                                    |
 |           |                                                                    |
 |30         |   100.0 100.0 100.0 100.0 100.0 100.0  96.0  84.0  84.0  78.0      |
 |PPM   1-1  |                                                                    |
 |           |                                                                    |
 |100        |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  95.9  83.7  73.5      |
 |PPM  10-3  |                                                                    |
 |           |                                                                    |
 |100        |   100.0 100.0  98.0  98.0  98.0  96.0  94.0  88.0  76.0  66.0      |
 |PPM  3-3   |                                                                    |
 |           |                                                                    |
 |100        |   100.0 100.0 100.0  98.0  94.0  94.0  94.0  89.9  85.8  81.7      |
 |PPM  0-3   |                                                                    |
 |           |                                                                    |
 |300        |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  98.0  96.0  88.0      |
 |PPM  10-10 |                                                                    |
 |           |                                                                    |
 |300        |    88.0  86.0  84.0  84.0  82.0  82.0  82.0  82.0  74.0  68.0      |
 |PPM  0-10  |                                                                    |
 |           |                                                                    |
 ==================================================================================

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 734 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0 PPM   0-0 O           30          100         100         100         300         300      |
 |                                            PPM    10-0 PPM   1-1   PPM  10-3   PPM  3-3    PPM  0-3    PPM  10-10  PPM  0-10|
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       78.0%       74.0%       78.0%       73.5%       66.0%       81.7%       88.0%       68.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.862N     -----      P=1.000     P=0.764     P=0.245     P=0.897N    P=0.251N    P=0.282  |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       632.7       632.2       593.5       651.8       609.6       551.0       665.2       351.2    |
 |NATURAL DEATHS (C)      |       (21.3)      (17.3)      (22.3)      (11.9)      (29.4)      (45.8)      (23.1)      (76.7)   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       711.7       707.5       703.1       706.5       691.7       695.0       725.7       611.5    |
 |(STANDARD ERROR)        |       ( 7.5)      ( 7.7)      ( 9.6)      ( 8.2)      (12.9)      (13.8)      ( 4.1)      (35.0)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 0 PPM    0-0                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      128   373   544   620   621   629   631   645   655   670                 |
 |      670   670   712   726                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0 PPM    10-0                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      364   486   491   528   530   579   580   607   607   617                 |
 |      648   660   673   674   682   703                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 60 PPM   1-1                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      395   461   481   544   565   575   587   619   628   633                 |
 |      636   638   682   690   721                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 200 PPM  10-3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 0    TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      411   525   561   635   644   654   656   659   670   675                 |
 |      690   725   735                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 200 PPM  3-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 0    TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      185   574   619   625   643   653   660   675   687   702                 |
 |      730   735                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 200 PPM  0-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 0    TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      394   465   565   574   636   662   675   680   689   690                 |
 |      717   730                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 600 PPM  10-10                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 10     CENSORED DEATHS 0    TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      503   587   600   637   642   670   687   719   724   730                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 600 PPM  0-10                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 0    TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      423   568   570   584   627   664   669   681   686   709                 |
 |      716   726   729                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   736 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0          |   100.0  98.0  98.0  98.0  96.0  96.0  94.0  94.0  82.0  72.0      |
 |PPM    0-0 |                                                                    |
 |           |                                                                    |
 |0          |   100.0 100.0 100.0  98.0  98.0  98.0  90.0  86.0  76.0  68.0      |
 |PPM    10-0|                                                                    |
 |           |                                                                    |
 |60         |   100.0 100.0 100.0 100.0  98.0  94.0  92.0  86.0  76.0  70.0      |
 |PPM   1-1  |                                                                    |
 |           |                                                                    |
 |200        |   100.0 100.0 100.0 100.0  98.0  98.0  96.0  94.0  84.0  74.0      |
 |PPM  10-3  |                                                                    |
 |           |                                                                    |
 |200        |   100.0 100.0  98.0  98.0  98.0  98.0  98.0  96.0  86.0  76.0      |
 |PPM  3-3   |                                                                    |
 |           |                                                                    |
 |200        |   100.0 100.0 100.0 100.0  98.0  96.0  96.0  92.0  88.0  76.0      |
 |PPM  0-3   |                                                                    |
 |           |                                                                    |
 |600        |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  94.0  90.0  80.0      |
 |PPM  10-10 |                                                                    |
 |           |                                                                    |
 |600        |   100.0 100.0 100.0 100.0  98.0  98.0  98.0  92.0  88.0  74.0      |
 |PPM  0-10  |                                                                    |
 |           |                                                                    |
 ==================================================================================

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0           0           60          200         200         200         600         600      |
 |                                PPM    0-0  PPM    10-0 PPM   1-1   PPM  10-3   PPM  3-3    PPM  0-3    PPM  10-10  PPM  0-10|
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       72.0%       68.0%       70.0%       74.0%       76.0%       76.0%       80.0%       74.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.210N     -----      P=0.893     P=0.919N    P=0.746N    P=0.743N    P=0.430N    P=0.910N |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       592.4       589.3       590.3       633.8       624.0       623.1       649.9       642.5    |
 |NATURAL DEATHS (C)      |       (42.4)      (22.7)      (23.3)      (24.4)      (42.1)      (30.1)      (22.8)      (24.2)   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       695.8       689.1       692.3       709.4       709.1       708.9       718.8       711.7    |
 |(STANDARD ERROR)        |       (14.8)      (12.1)      (11.7)      ( 8.9)      (11.9)      ( 9.8)      ( 6.6)      ( 8.5)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                         DIPHENYLHYDANTOIN
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM   0-0      = 1
                                                        O PPM    10-0    = 2
                                                        30 PPM   1-1     = 3
                                                        100 PPM  10-3    = 4
                                                        100 PPM  3-3     = 5
                                                        100 PPM  0-3     = 6
                                                        300 PPM  10-10   = 7
                                                        300 PPM  0-10    = 8

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1     8                            5            6                         1   2          7  4
      |
      |                                    5            6                6        1 5 2 3     1  7 2         7
      |                                                                  6 6        5   3    51     4   1 4  7     7
   95 +
      |                                                                    6                 533 5 2  6 1 4 41     77
P     |                                                                                        3  3     2   211     7   7
E     |
R  90 +                                                                                          53 3 6     6 1   1     77
C     |
E     |       8          8                                                                        5         46   411     7  7
N     |                  8                     8                                                    3  3    22     6
T  85 +
      |                                        8                         8                             3     22  434 6
S     |                                                                  8                               8    22  311  3
U     |                                                                                                              6      6
R  80 +                                                                                                  8  8 52 5 4 4233
V     |
I     |                                                                                                     88      142432  1
V     |                                                                                                      88  5  5
A  75 +                                                                                                                4  4
L     |                                                                                                       8     5 58 24 2
      |                                                                                                               585
      |
   70 +                                                                                                                 558
      |
      |                                                                                                                  55 8
      |                                                                                                                   5 5
   65 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 25 obs hidden.

                                                         DIPHENYLHYDANTOIN
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM    0-0     = 1
                                                        0 PPM    10-0    = 2
                                                        60 PPM   1-1     = 3
                                                        200 PPM  10-3    = 4
                                                        200 PPM  3-3     = 5
                                                        200 PPM  0-3     = 6
                                                        600 PPM  10-10   = 7
                                                        600 PPM  0-10    = 8

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                    1        5                          2     3 4 8           7
      |
      |                      1        5                          2 1   3 4 8     36  2 7   4      5 7
      |
   96 +                                                            1             36 322    4  1  45 7  7  5
      |
      |                                                                             3 2     2 1  46 8  7  154
      |
P  92 +                                                                                       3  36 8      544
E     |
R     |                                                                                     2    3 2      1164 4 67
C     |
E  88 +                                                                                            33      11  5 576 7
N     |
T     |                                                                                            23   2 3 1 14 48567   7
      |
S  84 +                                                                                                   33  11 44565   77
U     |
R     |                                                                                                 2 233  1  1485 58 7 7
V     |
I  80 +                                                                                                   2   2    4 4 586  57
V     |
A     |                                                                                                     332  2   4   64 6
L     |
   76 +                                                                                                      3   2123   1 4 45
      |
      |                                                                                                             33  1 1 44
      |
   72 +                                                                                                            223   31  1
      |
      |                                                                                                             2  2 3   3
      |
   68 +                                                                                                                2     2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 47 obs hidden.

--multipart-boundary
Content-type: text/plain
Range: bytes 41831-41831/41831


--multipart-boundary--