Share This:
https://ntp.niehs.nih.gov/go/2137

TDMS Study 05075-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         DIPHENYLHYDANTOIN


NTP Experiment-Test: 05075-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/09/94
Route: DOSED FEED                                                                                                 Time: 09:05:50




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57-41-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        240 PPM      800 PPM      800 PPM      800 PPM         
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17           19           19            9           19           15           
    Natural Death                                      2            2            4            4            2            2           
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           29           27           37           28           33           
    Moribund Sacrifice                                                                                     1                        
  Animals Examined Microscopically                    50           50           50           50           50           50           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (21)         (22)         (13)         (22)         (17)         
   Intestine Large, Cecum                             (48)         (20)         (20)         (9)          (19)         (16)         
   Intestine Large, Colon                             (49)         (20)         (20)         (10)         (20)         (16)         
   Intestine Large, Rectum                            (49)         (20)         (20)         (9)          (20)         (16)         
   Intestine Small, Duodenum                          (49)         (20)         (20)         (10)         (20)         (16)         
   Intestine Small, Ileum                             (49)         (20)         (20)         (9)          (20)         (15)         
   Intestine Small, Jejunum                           (49)         (20)         (20)         (9)          (20)         (17)         
      Adenocarcinoma                                                                                                    1 (6%)      
   Liver                                              (50)         (49)         (50)         (50)         (50)         (50)         
      Hepatocellular Adenoma                                                                  1 (2%)                                
      Hepatocellular Adenoma, Multiple                                                                     1 (2%)                   
   Mesentery                                          (3)          (6)          (3)          (1)          (1)          (2)          
   Pancreas                                           (50)         (20)         (23)         (10)         (21)         (16)         
   Salivary Glands                                    (50)         (21)         (22)         (12)         (22)         (17)         
      Carcinoma, Metastatic                                         1 (5%)                                                          
   Stomach, Forestomach                               (49)         (20)         (23)         (11)         (22)         (16)         
   Stomach, Glandular                                 (49)         (20)         (20)         (11)         (20)         (16)         
   Tongue                                                                                                              (1)          
      Squamous Cell Carcinoma                                                                                           1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (21)         (24)         (13)         (22)         (17)         
      Endocardium, Schwannoma Benign                                                                       1 (5%)                   
      Pericardium, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                                                             1 (6%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        240 PPM      800 PPM      800 PPM      800 PPM         
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (21)         (23)         (13)         (20)         (17)         
      Adenoma                                          2 (4%)                                                                       
      Carcinoma                                                                                                         1 (6%)      
   Adrenal Gland, Medulla                             (49)         (21)         (23)         (13)         (22)         (17)         
      Pheochromocytoma Malignant                                    1 (5%)                                                          
      Pheochromocytoma Benign                          4 (8%)       1 (5%)                                 1 (5%)       1 (6%)      
   Islets, Pancreatic                                 (50)         (20)         (23)         (11)         (21)         (16)         
      Adenoma                                          1 (2%)       1 (5%)       1 (4%)       1 (9%)                                
   Pituitary Gland                                    (50)         (41)         (43)         (32)         (35)         (33)         
      Pars Distalis, Adenoma                          25 (50%)     26 (63%)     15 (35%)     19 (59%)     15 (43%)     13 (39%)     
      Pars Distalis, Carcinoma                         1 (2%)                                 1 (3%)                                
   Thyroid Gland                                      (48)         (20)         (19)         (9)          (20)         (17)         
      Bilateral, C-Cell, Adenoma                       1 (2%)                    1 (5%)                                             
      C-Cell, Adenoma                                 12 (25%)      7 (35%)      4 (21%)      1 (11%)      3 (15%)      2 (12%)     
      C-Cell, Carcinoma                                2 (4%)                                                                       
      Follicular Cell, Adenocarcinoma                  1 (2%)                                              1 (5%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (45)         (21)         (24)         (14)         (24)         (20)         
      Adenoma                                          4 (9%)                    4 (17%)      2 (14%)      4 (17%)                  
      Carcinoma                                        2 (4%)                                                           1 (5%)      
      Squamous Cell Papilloma                                                                 1 (7%)                                
   Ovary                                              (49)         (23)         (26)         (19)         (26)         (21)         
   Uterus                                             (50)         (26)         (26)         (25)         (35)         (31)         
      Adenocarcinoma                                                                                       1 (3%)       1 (3%)      
      Leiomyoma                                                                                            1 (3%)                   
      Leiomyosarcoma                                   1 (2%)                    1 (4%)                                             
      Polyp Stromal                                    6 (12%)      4 (15%)      6 (23%)     11 (44%)     13 (37%)     11 (35%)     
      Polyp Stromal, Multiple                                       1 (4%)                                                          
      Sarcoma Stromal                                               1 (4%)                    1 (4%)       1 (3%)       1 (3%)      
      Cervix, Carcinoma Adenosquamous                                                                      1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (21)         (22)         (12)         (22)         (17)         
   Lymph Node                                         (49)         (21)         (26)         (12)         (23)         (22)         
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                1 (2%)                                                                       
                                                             Page   3                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        240 PPM      800 PPM      800 PPM      800 PPM         
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mesenteric                             (1)          (1)          (4)          (1)          (6)          (6)          
   Spleen                                             (50)         (26)         (29)         (17)         (22)         (21)         
      Hemangioma                                                                 1 (3%)                                             
   Thymus                                             (46)         (18)         (21)         (12)         (19)         (17)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (24)         (31)         (19)         (25)         (23)         
      Adenocarcinoma                                   3 (6%)       3 (13%)                   2 (11%)                               
      Adenoma                                          1 (2%)       1 (4%)                                 1 (4%)                   
      Fibroadenoma                                    16 (32%)      9 (38%)     14 (45%)      6 (32%)      6 (24%)      6 (26%)     
      Fibroadenoma, Multiple                           1 (2%)                                                                       
   Skin                                               (50)         (22)         (23)         (14)         (26)         (18)         
      Keratoacanthoma                                  1 (2%)                                              1 (4%)                   
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                                       1 (5%)                    1 (7%)       2 (8%)       1 (6%)      
      Trichoepithelioma                                1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                                                                         1 (4%)                   
      Subcutaneous Tissue, Fibrosarcoma                             1 (5%)                                 1 (4%)                   
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (21)         (23)         (13)         (22)         (17)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (22)         (24)         (13)         (23)         (18)         
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                           1 (6%)      
      Carcinoma, Metastatic, Adrenal Gland                                                                              1 (6%)      
      Sarcoma, Metastatic                                                                                               1 (6%)      
   Nose                                               (50)         (21)         (23)         (13)         (22)         (17)         
   Trachea                                            (50)         (21)         (22)         (12)         (22)         (17)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        240 PPM      800 PPM      800 PPM      800 PPM         
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (3)                                    (1)          (1)          (1)          
      Pinna, Sarcoma                                                                          1 (100%)     1 (100%)                 
   Eye                                                (9)          (6)          (6)          (7)          (7)          (9)          
      Lids, Fibrosarcoma                               1 (11%)                                                                      
   Harderian Gland                                    (3)          (1)          (3)          (1)          (1)                       
   Zymbal's Gland                                                  (1)          (1)          (1)                                    
      Carcinoma                                                     1 (100%)     1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (21)         (23)         (13)         (22)         (17)         
   Urinary Bladder                                    (50)         (21)         (20)         (11)         (20)         (16)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)        *(50)        *(50)         
      Leukemia Mononuclear                            13 (26%)     16 (32%)     21 (42%)     10 (20%)     10 (20%)     14 (28%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        240 PPM      800 PPM      800 PPM      800 PPM         
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          40          40          38          40          38               
     Total Primary Neoplasms                          102          75          69          59          66          55               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41          33          27          34          33          27               
     Total Benign Neoplasms                            76          51          46          43          50          34               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          22          23          16          14          20               
     Total Malignant Neoplasms                         26          24          23          16          16          21               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1                                               3               
     Total Metastatic Neoplasm                          1           1                                               3               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   2400 PPM     2400 PPM                                                            
                                                      0-10         10-10                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11           13                                                               
    Natural Death                                      1            1                                                               
    Drowned                                                         5                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           31                                                               
    Moribund Sacrifice                                 1                                                                            
  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)                                                             
   Intestine Large, Colon                             (50)         (50)                                                             
   Intestine Large, Rectum                            (50)         (50)                                                             
   Intestine Small, Ileum                             (48)         (50)                                                             
   Liver                                              (50)         (50)                                                             
      Hepatocellular Adenoma                           1 (2%)                                                                       
   Mesentery                                          (1)          (1)                                                              
   Pancreas                                           (50)         (50)                                                             
   Salivary Glands                                    (49)         (50)                                                             
   Stomach, Forestomach                               (50)         (50)                                                             
   Stomach, Glandular                                 (50)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)                                                             
      Endocardium, Schwannoma Benign                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)                                                             
   Adrenal Gland, Medulla                             (50)         (50)                                                             
      Pheochromocytoma Benign                          2 (4%)       3 (6%)                                                          
   Parathyroid Gland                                  (48)         (47)                                                             
   Pituitary Gland                                    (50)         (50)                                                             
      Pars Distalis, Adenoma                          13 (26%)     13 (26%)                                                         
   Thyroid Gland                                      (50)         (49)                                                             
      Bilateral, C-Cell, Adenoma                       1 (2%)       1 (2%)                                                          
      C-Cell, Adenoma                                  4 (8%)       4 (8%)                                                          
      Follicular Cell, Adenocarcinoma                               1 (2%)                                                          
                                                             Page   7                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   2400 PPM     2400 PPM                                                            
                                                      0-10         10-10                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (49)                                                             
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        1 (2%)       1 (2%)                                                          
   Ovary                                              (50)         (50)                                                             
      Granulosa Cell Tumor Malignant                   1 (2%)                                                                       
   Uterus                                             (50)         (50)                                                             
      Polyp Stromal                                   12 (24%)      6 (12%)                                                         
      Sarcoma Stromal                                               1 (2%)                                                          
      Endometrium, Adenocarcinoma                                   1 (2%)                                                          
      Endometrium, Adenoma                             1 (2%)                                                                       
      Endometrium, Sarcoma Stromal                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)                                                             
   Lymph Node                                         (49)         (50)                                                             
   Lymph Node, Mesenteric                             (4)          (3)                                                              
   Spleen                                             (50)         (50)                                                             
   Thymus                                             (45)         (48)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)                                                             
      Fibroadenoma                                     4 (8%)       2 (4%)                                                          
   Skin                                               (50)         (50)                                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   2400 PPM     2400 PPM                                                            
                                                      0-10         10-10                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
   Peripheral Nerve                                                (1)                                                              
      Spinal, Schwannoma Malignant                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)                                                             
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Carcinoma, Metastatic, Zymbal's Gland            1 (2%)                                                                       
   Nose                                               (49)         (50)                                                             
   Trachea                                            (50)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (7)          (2)                                                              
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
   Urinary Bladder                                    (50)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)                                                             
      Leukemia Mononuclear                            13 (26%)      8 (16%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   2400 PPM     2400 PPM                                                            
                                                      0-10         10-10                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            39          26                                                               
     Total Primary Neoplasms                           58          43                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 31          21                                                               
     Total Benign Neoplasms                            42          29                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16          14                                                               
     Total Malignant Neoplasms                         16          14                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                                                                           
     Total Metastatic Neoplasm                          1                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        240 PPM      800 PPM      800 PPM      800 PPM         
                                                   0-0          10-0          1-1           0-3           3-3        10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                22           21           13           21           24           21           
    Natural Death                                      2            5            4            3            4            6           
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           23           33           26           21           21           
    Moribund Sacrifice                                 1            1                                      1                        
    Natural Death                                                                                                       2           
  Animals Examined Microscopically                    50           50           50           50           50           50           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (22)         (13)         (22)         (26)         (21)         
   Intestine Large, Colon                             (49)         (24)         (14)         (22)         (26)         (23)         
   Intestine Large, Rectum                            (48)         (24)         (14)         (22)         (26)         (22)         
   Intestine Small, Duodenum                          (48)         (25)         (15)         (23)         (26)         (25)         
   Intestine Small, Ileum                             (46)         (22)         (13)         (23)         (26)         (23)         
   Intestine Small, Jejunum                           (48)         (24)         (13)         (22)         (26)         (22)         
   Liver                                              (50)         (50)         (49)         (50)         (49)         (49)         
      Hepatocellular Carcinoma                                                   1 (2%)       1 (2%)                                
      Hepatocellular Adenoma                                        1 (2%)       1 (2%)       1 (2%)       1 (2%)       1 (2%)      
      Hepatocellular Adenoma, Multiple                                           1 (2%)                    1 (2%)                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                    1 (2%)                   
   Mesentery                                          (7)          (3)          (3)          (3)          (7)          (2)          
   Pancreas                                           (50)         (27)         (16)         (23)         (28)         (25)         
   Salivary Glands                                    (48)         (27)         (16)         (23)         (27)         (28)         
   Stomach, Forestomach                               (49)         (26)         (15)         (24)         (27)         (26)         
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                                       1 (4%)                                                          
   Stomach, Glandular                                 (49)         (25)         (15)         (23)         (26)         (23)         
   Tongue                                                                                    (1)          (2)                       
      Squamous Cell Papilloma                                                                 1 (100%)     1 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (28)         (18)         (25)         (29)         (29)         
      Schwannoma Benign                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  11                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        240 PPM      800 PPM      800 PPM      800 PPM         
                                                   0-0          10-0          1-1           0-3           3-3        10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)         (50)         (48)         (49)         
   Adrenal Gland, Cortex                              (50)         (50)         (48)         (49)         (47)         (49)         
   Adrenal Gland, Medulla                             (50)         (50)         (50)         (49)         (48)         (49)         
      Pheochromocytoma Malignant                                    1 (2%)       2 (4%)       1 (2%)       2 (4%)       4 (8%)      
      Pheochromocytoma Benign                         13 (26%)     11 (22%)     11 (22%)     19 (39%)      4 (8%)      16 (33%)     
      Bilateral, Pheochromocytoma Benign               6 (12%)      1 (2%)       5 (10%)      7 (14%)      7 (15%)      3 (6%)      
   Islets, Pancreatic                                 (50)         (27)         (15)         (23)         (28)         (25)         
      Adenoma                                          3 (6%)       1 (4%)                                              1 (4%)      
      Carcinoma                                        1 (2%)                                              1 (4%)       1 (4%)      
   Pituitary Gland                                    (50)         (34)         (20)         (31)         (30)         (27)         
      Pars Distalis, Adenoma                          14 (28%)     10 (29%)      6 (30%)      8 (26%)     10 (33%)      5 (19%)     
      Pars Intermedia, Adenoma                                                                1 (3%)                                
      Pars Nervosa, Histiocytic Sarcoma                1 (2%)                                                                       
   Thyroid Gland                                      (49)         (26)         (14)         (22)         (27)         (23)         
      Bilateral, C-Cell, Adenoma                       3 (6%)                    1 (7%)       1 (5%)                    1 (4%)      
      C-Cell, Adenoma                                  8 (16%)     11 (42%)      6 (43%)      5 (23%)      5 (19%)      5 (22%)     
      C-Cell, Carcinoma                                1 (2%)       1 (4%)                                 2 (7%)       1 (4%)      
      Follicular Cell, Adenocarcinoma                  1 (2%)       2 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                       (2)          (1)          (1)                       
      Chemodectoma Benign                                                        1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (48)         (27)         (17)         (24)         (27)         (30)         
   Preputial Gland                                    (49)         (27)         (18)         (24)         (33)         (29)         
      Adenoma                                          2 (4%)       1 (4%)       1 (6%)       2 (8%)       1 (3%)                   
      Carcinoma                                        2 (4%)       1 (4%)                                 1 (3%)       1 (3%)      
   Prostate                                           (49)         (27)         (17)         (24)         (28)         (29)         
   Testes                                             (50)         (50)         (50)         (48)         (50)         (49)         
      Adenoma                                          1 (2%)                                                                       
      Bilateral, Interstitial Cell, Adenoma           42 (84%)     45 (90%)     42 (84%)     43 (90%)     42 (84%)     41 (84%)     
      Interstitial Cell, Adenoma                       4 (8%)       5 (10%)      5 (10%)      5 (10%)      8 (16%)      5 (10%)     
      Interstitial Cell, Carcinoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (26)         (16)         (23)         (28)         (29)         
      Femoral, Histiocytic Sarcoma                     1 (2%)                    1 (6%)                    1 (4%)                   
   Lymph Node                                         (50)         (27)         (19)         (26)         (29)         (29)         
      Mandibular, Histiocytic Sarcoma                  1 (2%)                    1 (5%)                    1 (3%)                   
                                                             Page  12                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        240 PPM      800 PPM      800 PPM      800 PPM         
                                                   0-0          10-0          1-1           0-3           3-3        10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Mediastinal, Histiocytic Sarcoma                                           1 (5%)                    1 (3%)                   
   Lymph Node, Mesenteric                             (5)          (7)          (4)          (5)          (8)          (4)          
   Spleen                                             (49)         (33)         (29)         (31)         (35)         (29)         
      Hemangiosarcoma                                                                                                   1 (3%)      
      Histiocytic Sarcoma                                                        1 (3%)                    1 (3%)                   
      Sarcoma                                                                                                           1 (3%)      
   Thymus                                             (40)         (23)         (15)         (23)         (28)         (25)         
      Thymoma Benign                                                                                       1 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (23)         (12)         (8)          (7)          (14)         (7)          
      Adenocarcinoma                                   1 (4%)                                                                       
      Fibroadenoma                                     3 (13%)      1 (8%)       4 (50%)                   1 (7%)       1 (14%)     
      Sarcoma                                                                                                           1 (14%)     
   Skin                                               (49)         (29)         (20)         (31)         (29)         (30)         
      Basal Cell Adenoma                                                                      2 (6%)                                
      Keratoacanthoma                                  1 (2%)       1 (3%)                    3 (10%)      1 (3%)       1 (3%)      
      Squamous Cell Carcinoma                          2 (4%)                                                           1 (3%)      
      Squamous Cell Papilloma                                       1 (3%)                    2 (6%)                                
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (3%)       4 (20%)      2 (6%)       1 (3%)                   
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                 2 (6%)                                
      Subcutaneous Tissue, Hemangiosarcoma                                                    1 (3%)                    1 (3%)      
      Subcutaneous Tissue, Osteosarcoma                             1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (27)         (18)         (25)         (29)         (27)         
      Osteosarcoma                                                                                         1 (3%)                   
      Vertebra, Osteosarcoma                                                                               1 (3%)                   
   Skeletal Muscle                                    (1)                       (1)                       (1)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (27)         (17)         (24)         (29)         (29)         
      Astrocytoma Benign                               1 (2%)                                                                       
      Astrocytoma Malignant                                         1 (4%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Peripheral Nerve                                                (1)                                    (1)                       
      Schwannoma Malignant                                          1 (100%)                               1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  13                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        240 PPM      800 PPM      800 PPM      800 PPM         
                                                   0-0          10-0          1-1           0-3           3-3        10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (27)         (18)         (24)         (30)         (29)         
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (4%)                                              1 (3%)      
      Alveolar/Bronchiolar Carcinoma                                             1 (6%)                                             
      Carcinoma                                        1 (2%)                                                                       
      Carcinoma, Metastatic                                                      1 (6%)                                             
      Histiocytic Sarcoma                              1 (2%)                    1 (6%)                    1 (3%)                   
      Osteosarcoma, Metastatic                                                                             1 (3%)                   
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                                                                 1 (3%)      
   Nose                                               (50)         (27)         (17)         (24)         (29)         (29)         
      Polyp                                            1 (2%)                                                                       
      Nasolacrimal Duct, Histiocytic Sarcoma           1 (2%)                                                                       
   Trachea                                            (50)         (27)         (17)         (25)         (29)         (28)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (1)                                    (2)          (3)          
      Pinna, Basosquamous Tumor Benign                                                                                  1 (33%)     
      Pinna, Fibrosarcoma                                                                                               1 (33%)     
   Eye                                                (9)          (3)          (6)          (4)          (3)          (6)          
      Squamous Cell Carcinoma                                                                                           1 (17%)     
   Harderian Gland                                    (2)          (1)          (1)                       (1)          (1)          
   Zymbal's Gland                                     (1)                                    (1)          (1)          (2)          
      Adenoma                                                                                              1 (100%)                 
      Carcinoma                                                                               1 (100%)                  2 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (28)         (21)         (28)         (31)         (30)         
      Sarcoma                                          1 (2%)                                                                       
      Transitional Epithelium, Carcinoma                                                                   1 (3%)       1 (3%)      
   Urinary Bladder                                    (48)         (26)         (15)         (23)         (27)         (24)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)        *(50)        *(50)         
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                    1 (2%)                   
      Leukemia Mononuclear                            25 (50%)     25 (50%)     22 (44%)     24 (48%)     22 (44%)      9 (18%)     
      Mesothelioma Malignant                           2 (4%)       1 (2%)       1 (2%)       3 (6%)       1 (2%)       3 (6%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  14                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        240 PPM      800 PPM      800 PPM      800 PPM         
                                                   0-0          10-0          1-1           0-3           3-3        10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          49          50          50          49               
     Total Primary Neoplasms                          145         126         117         135         119         111               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 50          50          48          50          50          47               
     Total Benign Neoplasms                           105          92          88         102          85          82               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              36          30          28          28          30          24               
     Total Malignant Neoplasms                         40          34          29          33          34          29               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                      1                       2           1               
     Total Metastatic Neoplasm                                                  1                       2           1               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  15                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     2400 PPM     2400 PPM                                                            
                                                    0-10        10-10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                25           17                                                               
    Natural Death                                      3            2                                                               
  Survivors                                                                                                                         
    Moribund Sacrifice                                 1            1                                                               
    Terminal Sacrifice                                21           30                                                               
  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (50)                                                             
   Intestine Large, Cecum                             (47)         (48)                                                             
   Intestine Large, Colon                             (46)         (48)                                                             
   Intestine Large, Rectum                            (47)         (49)                                                             
   Intestine Small, Duodenum                          (48)         (48)                                                             
   Intestine Small, Ileum                             (47)         (48)                                                             
   Intestine Small, Jejunum                           (48)         (48)                                                             
   Liver                                              (50)         (49)                                                             
      Hepatocellular Adenoma                           3 (6%)       1 (2%)                                                          
      Hepatocellular Adenoma, Multiple                 1 (2%)       4 (8%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Mesentery                                          (6)          (4)                                                              
   Pancreas                                           (48)         (50)                                                             
   Salivary Glands                                    (49)         (50)                                                             
   Stomach, Forestomach                               (49)         (48)                                                             
      Leiomyosarcoma                                                1 (2%)                                                          
   Stomach, Glandular                                 (49)         (48)                                                             
   Tooth                                              (1)                                                                           
      Molar, Adamantinoma Benign                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)                                                             
      Carcinoma, Metastatic                            1 (2%)                                                                       
      Ventricle Left, Schwannoma Benign                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  16                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     2400 PPM     2400 PPM                                                            
                                                    0-10        10-10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (50)                                                             
   Adrenal Gland, Cortex                              (49)         (50)                                                             
      Adenoma                                          1 (2%)       2 (4%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Adrenal Gland, Medulla                             (48)         (50)                                                             
      Pheochromocytoma Malignant                                    3 (6%)                                                          
      Pheochromocytoma Benign                         16 (33%)     16 (32%)                                                         
      Bilateral, Pheochromocytoma Benign               9 (19%)     11 (22%)                                                         
   Parathyroid Gland                                  (49)         (44)                                                             
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (48)         (49)                                                             
      Pars Distalis, Adenoma                          10 (21%)      9 (18%)                                                         
   Thyroid Gland                                      (48)         (49)                                                             
      Bilateral, C-Cell, Adenoma                                    4 (8%)                                                          
      C-Cell, Adenoma                                 10 (21%)     10 (20%)                                                         
      C-Cell, Carcinoma                                1 (2%)       4 (8%)                                                          
      Follicular Cell, Adenocarcinoma                  1 (2%)                                                                       
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (48)                                                             
   Preputial Gland                                    (49)         (50)                                                             
      Adenoma                                                       2 (4%)                                                          
   Prostate                                           (50)         (49)                                                             
   Testes                                             (49)         (49)                                                             
      Bilateral, Interstitial Cell, Adenoma           40 (82%)     35 (71%)                                                         
      Interstitial Cell, Adenoma                       6 (12%)     10 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)                                                             
      Femoral, Histiocytic Sarcoma                                  1 (2%)                                                          
      Sternal, Histiocytic Sarcoma                                  1 (2%)                                                          
      Vertebral, Histiocytic Sarcoma                                1 (2%)                                                          
   Lymph Node                                         (50)         (50)                                                             
      Deep Cervical, Mediastinal, Mandibular,                                                                                       
          Carcinoma, Metastatic, Thyroid Gland         1 (2%)       1 (2%)                                                          
                                                             Page  17                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     2400 PPM     2400 PPM                                                            
                                                    0-10        10-10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Mandibular, Carcinoma, Metastatic, Skin          1 (2%)                                                                       
      Mediastinal, Histiocytic Sarcoma                              1 (2%)                                                          
   Lymph Node, Mesenteric                             (8)          (8)                                                              
   Spleen                                             (50)         (50)                                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Sarcoma                                                       1 (2%)                                                          
   Thymus                                             (35)         (39)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (19)         (18)                                                             
      Abdominal, Fibroadenoma                                       1 (6%)                                                          
   Skin                                               (49)         (50)                                                             
      Basal Cell Adenoma                                            1 (2%)                                                          
      Fibroma                                          1 (2%)                                                                       
      Keratoacanthoma                                  1 (2%)       1 (2%)                                                          
      Schwannoma Malignant                                          1 (2%)                                                          
      Squamous Cell Carcinoma                          2 (4%)       1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)                                                             
      Left, Femur, Osteosarcoma                        1 (2%)                                                                       
   Skeletal Muscle                                    (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
      Oligodendroglioma Malignant                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)                                                             
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       3 (6%)                                                          
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)       2 (4%)                                                          
      Pheochromocytoma Malignant, Metastatic                        1 (2%)                                                          
   Nose                                               (50)         (50)                                                             
   Trachea                                            (50)         (50)                                                             
      Lamina Propria, Carcinoma, Metastatic,                                                                                        
          Thyroid Gland                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page  18                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     2400 PPM     2400 PPM                                                            
                                                    0-10        10-10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (3)                                                              
   Harderian Gland                                    (4)                                                                           
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (49)         (49)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)                                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Leukemia Mononuclear                            19 (38%)     20 (40%)                                                         
      Mesothelioma Malignant                           1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  19                                                               
NTP Experiment-Test: 05075-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 09:05:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     2400 PPM     2400 PPM                                                            
                                                    0-10        10-10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50                                                               
     Total Primary Neoplasms                          133         146                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          49                                                               
     Total Benign Neoplasms                           104         108                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          30                                                               
     Total Malignant Neoplasms                         29          38                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           3                                                               
     Total Metastatic Neoplasm                          5           4                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  20                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------