National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2143

TDMS Study 05075-01 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/09/94   
EXP: 05075                    DIPHENYLHYDANTOIN                TIME: 09:36:21   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 55765    
CONT: NO1-ES-82151                                             CAS: 57-41-0     
PATHOLOGIST: M. RYAN                         S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/09/94  
EXP: 05075                    DIPHENYLHYDANTOIN                TIME: 09:36:21  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 55765   
CONT: NO1-ES-82151                                             CAS: 57-41-0    
PATHOLOGIST: M. RYAN                         S. EUSTIS                         

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 732 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM   0-0                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 24     CENSORED DEATHS 0    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      416   532   543   595   611   617   617   623   634   641                 |
 |      645   655   658   659   659   661   667   673   683   688                 |
 |      690   701   716   716                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0 PPM   10-0                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      473   519   530   544   569   570   597   603   613   627                 |
 |      632   646   651   659   662   662   666   666   679   687                 |
 |      688   714   715   718   718   718                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 240 PPM  1-1                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      331   340   549   549   603   617   617   630   631   654                 |
 |      654   673   675   683   709   717   723                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 732 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 800 PPM   0-3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 24     CENSORED DEATHS 0    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      508   568   571   582   603   605   606   626   627   648                 |
 |      672   676   690   690   704   708   708   709   709   715                 |
 |      715   717   729   730                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 800 PPM    3-3                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 28     CENSORED DEATHS 0    TERMINAL 22        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      426   487   568   606   606   620   626   634   634   645                 |
 |      652   660   661   661   661   664   667   672   673   687                 |
 |      688   689   695   701   701   704   709   729                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 800 PPM  10-3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 27     CENSORED DEATHS 0    TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      243   307   410   501   517   518   533   597   605   617                 |
 |      623   630   643   648   650   652   659   662   680   680                 |
 |      690   694   701   709   711   723   725                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 732 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 2400 PPM 0-10                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 28     CENSORED DEATHS 0    TERMINAL 22        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      209   425   438   475   490   494   515   596   609   617                 |
 |      629   631   642   647   662   666   667   680   683   687                 |
 |      689   695   696   697   711   722   725   725                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 2400 PPM10-10                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 0    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      399   428   561   568   581   597   617   620   639   648                 |
 |      655   657   657   665   674   709   715   723   725                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 732 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   732 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM   0-0|   100.0 100.0 100.0 100.0  98.0  98.0  94.0  92.0  68.0  52.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0          |   100.0 100.0 100.0 100.0 100.0  98.0  92.0  84.0  68.0  48.0      |
 |PPM   10-0 |                                                                    |
 |           |                                                                    |
 |240        |   100.0 100.0 100.0  96.0  96.0  96.0  96.0  90.0  78.0  66.0      |
 |PPM  1-1   |                                                                    |
 |           |                                                                    |
 |800        |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  88.0  80.0  52.0      |
 |PPM   0-3  |                                                                    |
 |           |                                                                    |
 |800        |   100.0 100.0 100.0 100.0 100.0  98.0  96.0  94.0  68.0  44.0      |
 |PPM    3-3 |                                                                    |
 |           |                                                                    |
 |800        |   100.0 100.0  98.0  96.0  94.0  94.0  86.0  82.0  64.0  46.0      |
 |PPM  10-3  |                                                                    |
 |           |                                                                    |
 |2400       |   100.0 100.0  98.0  98.0  96.0  92.0  86.0  84.0  70.0  44.0      |
 |PPM 0-10   |                                                                    |
 |           |                                                                    |
 |2400       |   100.0 100.0 100.0 100.0  98.0  96.0  96.0  88.0  72.0  62.0      |
 |PPM10-10   |                                                                    |
 |           |                                                                    |
 ==================================================================================

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 732 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0 PPM   0-0 0           240         800         800         800         2400        2400     |
 |                                            PPM   10-0  PPM  1-1    PPM   0-3   PPM    3-3  PPM  10-3   PPM 0-10    PPM10-10 |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       52.0%       48.0%       66.0%       52.0%       44.0%       46.0%       44.0%       62.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.979      -----      P=0.238N    P=0.895N    P=0.656     P=0.607     P=0.550     P=0.441N |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       637.5       635.6       609.1       659.0       647.4       604.7       611.5       623.1    |
 |NATURAL DEATHS (C)      |       (13.5)      (13.3)      (27.8)      (12.7)      (12.4)      (23.6)      (22.6)      (20.4)   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       686.6       681.9       690.2       697.0       684.6       663.3       664.5       690.6    |
 |(STANDARD ERROR)        |       ( 9.3)      ( 9.7)      (12.5)      ( 8.0)      ( 9.1)      (15.5)      (15.2)      (10.7)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM   0-0                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 0    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      116   388   421   470   484   513   586   593   595   602                 |
 |      629   655   657   659   677   684   698   700   700                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0 PPM   10-0                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      325   388   599   606   627   627   630   644   650   652                 |
 |      659   661   683   685   692   698   699   707   707   711                 |
 |      717                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 240 PPM  1-1                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      425   519   536   573   575   593   621   627   630   634                 |
 |      634   634   634   673   681   684   690   690   692   698                 |
 |      700   707   715                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 800 PPM  0-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 0    TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      248   255   470   509   586   602   609   611   624   654                 |
 |      672   697   711                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 800 PPM  3-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      439   512   519   536   600   606   609   630   637   659                 |
 |      662   671   676   676   690   690   699   699   702   707                 |
 |      718                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 800 PPM  10-3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      491   558   571   573   592   595   600   616   639   648                 |
 |      659   685   686   698   704   704   707                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 2400 PPM   0-10                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 0    TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      499   575   620   622   623   643   671   683   693   699                 |
 |      700   707                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 2400 PPM   10-10                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 5    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      395   540   544   582   587   593   593   630   643   671                 |
 |      671   672   711   714                                                     |
 |  CENSORED DEATHS                                                               |
 |      128   128   128   128   128                                               |
 |                                                                                |
 ==================================================================================

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM   0-0|   100.0  98.0  98.0  98.0  94.0  90.0  88.0  80.0  72.0  62.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0          |   100.0 100.0 100.0  98.0  96.0  96.0  96.0  94.0  76.0  58.0      |
 |PPM   10-0 |                                                                    |
 |           |                                                                    |
 |240        |   100.0 100.0 100.0 100.0  98.0  98.0  94.0  88.0  74.0  54.0      |
 |PPM  1-1   |                                                                    |
 |           |                                                                    |
 |800        |   100.0 100.0  96.0  96.0  96.0  94.0  92.0  88.0  80.0  74.0      |
 |PPM  0-3   |                                                                    |
 |           |                                                                    |
 |800        |   100.0 100.0 100.0 100.0 100.0  98.0  92.0  90.0  78.0  58.0      |
 |PPM  3-3   |                                                                    |
 |           |                                                                    |
 |800        |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  86.0  78.0  66.0      |
 |PPM  10-3  |                                                                    |
 |           |                                                                    |
 |2400       |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  96.0  88.0  76.0      |
 |PPM   0-10 |                                                                    |
 |           |                                                                    |
 |2400       |   100.0 100.0 100.0 100.0  97.8  97.8  93.3  84.4  80.0  68.9      |
 |PPM   10-10|                                                                    |
 |           |                                                                    |
 ==================================================================================

                                 DIPHENYLHYDANTOIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0 PPM   0-0 0           240         800         800         800         2400        2400     |
 |                                            PPM   10-0  PPM  1-1    PPM  0-3    PPM  3-3    PPM  10-3   PPM   0-10  PPM   10-|0
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       62.0%       58.0%       54.0%       74.0%       58.0%       66.0%       76.0%       68.9%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.038N     -----      P=0.676     P=0.288N    P=1.000     P=0.693N    P=0.140N    P=0.564N |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       569.8       636.5       633.3       557.5       635.1       630.9       644.6       610.4    |
 |NATURAL DEATHS (C)      |       (33.6)      (21.8)      (14.9)      (42.0)      (16.6)      (15.3)      (17.9)      (22.4)   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       668.5       690.2       685.0       684.4       689.6       695.7       708.7       635.7    |
 |(STANDARD ERROR)        |       (16.7)      (11.1)      ( 9.6)      (15.1)      ( 9.6)      ( 8.4)      ( 6.6)      (26.0)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                         DIPHENYLHYDANTOIN
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM   0-0      = 1
                                                        0 PPM   10-0     = 2
                                                        240 PPM  1-1     = 3
                                                        800 PPM   0-3    = 4
                                                        800 PPM    3-3   = 5
                                                        800 PPM  10-3    = 6
                                                        2400 PPM 0-10    = 7
                                                        2400 PPM10-10    = 8

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  104 +
      |
      | 1                                7     6             3         8  15       2    4
      |                                  7     6        6    33        8  158      2 5  4  21     4
   96 +                                                 6     3          6 787       5     21 13 85
      |                                                                  6   7     7   6    2 1  84 4 1 5
      |                                                                            7 7 6 6    23  284 1 31
      |                                                                              77            8   8311
P  88 +                                                                               7  6   6    2    2  55
E     |                                                                                  7   6         22 335
R     |                                                                                                6221318
C     |                                                                                                 62621143
E  80 +                                                                                                   722115  4
N     |                                                                                                   662 11 543
T     |                                                                                                    676     4 4
      |                                                                                                      621 1 33
S  72 +                                                                                                       7  7 834 43
U     |                                                                                                       66 778   433
R     |                                                                                                        6 11     833
V     |                                                                                                           117    83 3
I  64 +                                                                                                          6211
V     |                                                                                                            211  448 8
A     |                                                                                                             66
L     |                                                                                                              1612
   56 +                                                                                                              55121  4
      |                                                                                                               556
      |                                                                                                               7 71  1
      |                                                                                                                 6 6
   48 +                                                                                                                552  2
      |                                                                                                                 5 6 5
      |                                                                                                                   7 5
      |
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 90 obs hidden.

                                                         DIPHENYLHYDANTOIN
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM   0-0      = 1
                                                        0 PPM   10-0     = 2
                                                        240 PPM  1-1     = 3
                                                        800 PPM  0-3     = 4
                                                        800 PPM  3-3     = 5
                                                        800 PPM  10-3    = 6
                                                        2400 PPM   0-10  = 7
                                                        2400 PPM   10-10 = 8

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  104 +
      |
      | 1                  1                    4           2          8   3 5        67
      |                    1                    44          2         18   3 5        67 5 3  8 6  7
   96 +                                          4                    1    1       4     5 3 3  6 67   2  7
      |                                                                    1       1    4  5 38   3 8  22
P     |                                                                            1 1  4    5    334 652  2
E     |                                                                              1   1         34 345 7  7
R  88 +                                                                                  1          1 344 3  7    7
C     |                                                                                             1 164432 2    7 7
E     |                                                                                               8  4 4522     77
N     |                                                                                               11   33622 5   77
T  80 +                                                                                                1   1 862 24
      |                                                                                                    1   1 54 6 47
S     |                                                                                                          2552 474   7
U     |                                                                                                     3  1 1836 6 4   4
R  72 +                                                                                                          1 12266
V     |                                                                                                            1122
I     |                                                                                                             131 8   8
V     |                                                                                                               22    6
A  64 +                                                                                                               55
L     |                                                                                                              3122   1
      |                                                                                                                522
      |                                                                                                               33 2  2
   56 +                                                                                                                3 3
      |                                                                                                                  3  3
      |
      |
   48 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 51 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.