National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2443

TDMS Study 05077-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL


NTP Experiment-Test: 05077-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: DOSED FEED                                                                                                 Time: 09:16:37




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  67774327

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05077-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            3            5            2            4            8           
    Natural Death                                      4            2           13           10           13           25           
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           45           32           38           33           17           
  Animals Examined Microscopically                    50           50           50           50           50           50           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (50)         (45)         (46)         (38)         (45)         
   Intestine Large, Cecum                             (47)         (50)         (49)         (50)         (46)         (50)         
   Intestine Large, Rectum                            (49)         (50)         (48)         (50)         (46)         (50)         
   Intestine Small, Duodenum                          (48)         (50)         (49)         (50)         (50)         (47)         
      Adenoma                                                                                              1 (2%)                   
   Intestine Small, Ileum                             (46)         (50)         (46)         (50)         (47)         (45)         
   Intestine Small, Jejunum                           (47)         (50)         (47)         (49)         (47)         (44)         
      Adenocarcinoma                                   1 (2%)                                 1 (2%)                                
      Histiocytic Sarcoma                                                                                               1 (2%)      
   Liver                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Hemangiosarcoma                                                            1 (2%)       1 (2%)       3 (6%)                   
      Hemangiosarcoma, Single                                                                              1 (2%)                   
      Hepatocellular Carcinoma                                                                                          1 (2%)      
      Hepatocellular Carcinoma, Multiple                                                      8 (16%)     13 (26%)     22 (44%)     
      Hepatocellular Carcinoma, Single                 1 (2%)       4 (8%)       2 (4%)      14 (28%)     13 (26%)     21 (42%)     
      Hepatocellular Adenoma, Multiple                 1 (2%)       7 (14%)                  28 (56%)     31 (62%)     44 (88%)     
      Hepatocellular Adenoma, Single                   3 (6%)      12 (24%)      6 (12%)     11 (22%)      7 (14%)      3 (6%)      
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       3 (6%)       1 (2%)                    1 (2%)      
   Mesentery                                          (2)          (1)          (4)          (3)          (2)          (1)          
      Hemangioma                                                                 1 (25%)                                            
   Pancreas                                           (48)         (50)         (49)         (50)         (50)         (48)         
   Stomach, Forestomach                               (49)         (50)         (47)         (50)         (50)         (50)         
      Squamous Cell Papilloma                          1 (2%)       2 (4%)       2 (4%)                                 2 (4%)      
   Stomach, Glandular                                 (47)         (49)         (48)         (50)         (49)         (50)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)         (50)         (50)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05077-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (49)         (50)         (50)         (50)         (50)         
      Capsule, Histiocytic Sarcoma                                               1 (2%)                                             
   Adrenal Gland, Cortex                              (50)         (49)         (50)         (49)         (50)         (50)         
   Adrenal Gland, Medulla                             (50)         (49)         (50)         (49)         (50)         (49)         
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (48)         (49)         (47)         (50)         (47)         (43)         
      Adenoma                                                                                                           1 (2%)      
   Pituitary Gland                                    (48)         (47)         (49)         (48)         (47)         (44)         
      Pars Distalis, Adenoma                           5 (10%)      6 (13%)     10 (20%)     10 (21%)     11 (23%)      3 (7%)      
      Pars Intermedia, Adenoma                                                                1 (2%)                                
   Thyroid Gland                                      (49)         (50)         (50)         (50)         (50)         (50)         
      Bilateral, Follicular Cell, Adenoma                           1 (2%)                                              1 (2%)      
      Follicle, Adenoma                                                          1 (2%)                                             
      Follicular Cell, Adenoma                                      2 (4%)                    1 (2%)       1 (2%)       1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                               (2)                                    (1)          
      Carcinoma                                                                  1 (50%)                                1 (100%)    
   Ovary                                              (47)         (49)         (48)         (48)         (49)         (49)         
      Cystadenoma                                      1 (2%)                                                                       
      Granulosa Cell Tumor Benign                                   2 (4%)                                 1 (2%)                   
      Granulosa-Theca Tumor Benign                                                            1 (2%)                                
      Luteoma                                                       1 (2%)       1 (2%)                    2 (4%)                   
      Mixed Tumor Benign                                            1 (2%)                                 1 (2%)                   
      Osteosarcoma, Metastatic                                                   1 (2%)                                             
      Thecoma Benign                                   1 (2%)                                                                       
   Oviduct                                                         (1)          (2)                                                 
   Uterus                                             (49)         (50)         (49)         (50)         (49)         (49)         
      Adenocarcinoma                                                                          1 (2%)                                
      Hamartoma                                                                               1 (2%)                                
      Hemangioma                                                                                           1 (2%)                   
      Histiocytic Sarcoma                              1 (2%)                                                           1 (2%)      
      Leiomyosarcoma                                                                          1 (2%)                                
      Polyp Stromal                                    1 (2%)                    1 (2%)       1 (2%)                                
      Sarcoma Stromal                                  1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05077-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)         (50)         
      Femoral, Hemangiosarcoma                                                   3 (6%)       1 (2%)       2 (4%)                   
      Femoral, Histiocytic Sarcoma                                               1 (2%)                                             
      Sternal, Hemangiosarcoma                                                                2 (4%)                                
      Sternal, Histiocytic Sarcoma                                               1 (2%)                                             
   Lymph Node                                         (48)         (49)         (48)         (50)         (49)         (47)         
      Mandibular, Histiocytic Sarcoma                                            1 (2%)                                             
      Mediastinal, Carcinoma, Metastatic               1 (2%)                                                                       
      Mediastinal, Histiocytic Sarcoma                              1 (2%)                                              1 (2%)      
      Pancreatic, Histiocytic Sarcoma                                            1 (2%)                                             
      Renal, Histiocytic Sarcoma                                                 1 (2%)       1 (2%)                                
   Lymph Node, Mesenteric                             (8)          (21)         (15)         (21)         (23)         (20)         
      Histiocytic Sarcoma                                           1 (5%)       1 (7%)                                 1 (5%)      
   Spleen                                             (48)         (50)         (50)         (50)         (50)         (50)         
      Hemangiosarcoma                                  1 (2%)       1 (2%)       2 (4%)       3 (6%)       3 (6%)       1 (2%)      
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
   Thymus                                             (43)         (43)         (31)         (38)         (29)         (27)         
      Histiocytic Sarcoma                                                        1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (41)         (44)         (34)         (32)         (37)         (26)         
      Adenocarcinoma                                                             2 (6%)                    1 (3%)                   
   Skin                                               (49)         (50)         (49)         (49)         (50)         (50)         
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                    2 (4%)                                             
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                           1 (2%)      
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)       2 (4%)       1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)         (50)         (50)         (50)         
      Osteoma                                                                                 1 (2%)                                
      Osteosarcoma                                     1 (2%)                    1 (2%)                                             
   Skeletal Muscle                                    (1)          (1)          (1)                                    (1)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)         (50)         
   Peripheral Nerve                                   (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05077-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (50)         (50)         
      Alveolar/Bronchiolar Adenoma, Single                          2 (4%)       2 (4%)       2 (4%)       1 (2%)       3 (6%)      
      Alveolar/Bronchiolar Carcinoma, Single           1 (2%)       1 (2%)       3 (6%)                    1 (2%)       1 (2%)      
      Hepatocellular Carcinoma, Metastatic                                                                              1 (2%)      
      Hepatocellular Carcinoma, Metastatic, Liver                                             2 (4%)       2 (4%)       3 (6%)      
      Histiocytic Sarcoma                                                                                               1 (2%)      
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)         (49)         (50)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)                                                              
   Harderian Gland                                    (6)          (1)          (6)          (2)          (2)          (1)          
      Adenoma                                          3 (50%)      1 (100%)     4 (67%)      2 (100%)     2 (100%)                 
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)         (50)         (50)         
      Histiocytic Sarcoma                                                        1 (2%)                                 1 (2%)      
   Urinary Bladder                                    (48)         (50)         (49)         (48)         (49)         (49)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)        *(50)        *(50)         
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       3 (6%)       2 (4%)                    2 (4%)      
      Lymphoma Malignant Lymphocytic                   2 (4%)       2 (4%)       4 (8%)       2 (4%)       2 (4%)       2 (4%)      
      Lymphoma Malignant Mixed                         3 (6%)       2 (4%)       3 (6%)       3 (6%)       2 (4%)                   
      Lymphoma Malignant Undifferentiated Cell         1 (2%)       3 (6%)       6 (12%)      2 (4%)                    1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05077-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            25          35          36          46          49          50               
     Total Primary Neoplasms                           33          51          64         102         101         111               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 16          28          22          39          42          47               
     Total Benign Neoplasms                            18          37          28          59          59          59               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              13          13          26          31          32          45               
     Total Malignant Neoplasms                         15          14          36          43          42          52               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                       1           2           2           4               
     Total Metastatic Neoplasm                          1                       2           2           2           4               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05077-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Natural Death                                     34           35                                                               
    Moribund Sacrifice                                16           15                                                               
  Survivors                                                                                                                         
  Animals Examined Microscopically                    49           49                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (48)         (47)                                                             
      Hepatocellular Carcinoma, Multiple              21 (44%)      9 (19%)                                                         
      Hepatocellular Carcinoma, Single                14 (29%)     20 (43%)                                                         
      Hepatocellular Adenoma, Multiple                41 (85%)     36 (77%)                                                         
      Hepatocellular Adenoma, Single                   5 (10%)      5 (11%)                                                         
   Stomach, Forestomach                               (45)         (46)                                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Medulla                             (43)         (47)                                                             
      Pheochromocytoma Benign                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (45)         (46)                                                             
      Teratoma                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05077-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (47)                                                             
      Subcutaneous Tissue, Hemangioma                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (46)         (44)                                                             
      Alveolar/Bronchiolar Adenoma, Single             1 (2%)       1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       4 (9%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                             Page   8                                                               
NTP Experiment-Test: 05077-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          47                                                               
     Total Primary Neoplasms                           84          73                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          41                                                               
     Total Benign Neoplasms                            49          44                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              35          29                                                               
     Total Malignant Neoplasms                         35          29                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           4                                                               
     Total Metastatic Neoplasm                          1           4                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   9                                                               
NTP Experiment-Test: 05077-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           49           50           50           50           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9            5            2            5            2            3           
    Natural Death                                     10           13            5           11           14           18           
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           32           41           34           33           27           
    Natural Death                                                                1                         1            2           
  Animals Examined Microscopically                    50           50           49           50           50           50           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (49)         (50)         (50)         (49)         
   Gallbladder                                        (38)         (43)         (45)         (43)         (39)         (36)         
   Intestine Large, Cecum                             (47)         (49)         (44)         (49)         (49)         (48)         
   Intestine Large, Rectum                            (50)         (49)         (44)         (48)         (48)         (47)         
   Intestine Small, Duodenum                          (49)         (49)         (45)         (49)         (49)         (47)         
      Adenoma                                                                    1 (2%)                                             
   Intestine Small, Ileum                             (47)         (47)         (45)         (46)         (49)         (43)         
   Intestine Small, Jejunum                           (48)         (45)         (47)         (46)         (48)         (47)         
      Adenocarcinoma                                   1 (2%)                                                                       
   Liver                                              (50)         (50)         (48)         (49)         (49)         (50)         
      Fibrosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (2%)                                                          
      Hemangiosarcoma                                  3 (6%)       5 (10%)      3 (6%)       4 (8%)       3 (6%)       2 (4%)      
      Hemangiosarcoma, Single                                                                 1 (2%)                                
      Hepatocellular Carcinoma                                                                1 (2%)                    1 (2%)      
      Hepatocellular Carcinoma, Multiple               4 (8%)       6 (12%)      2 (4%)      13 (27%)     14 (29%)     21 (42%)     
      Hepatocellular Carcinoma, Single                 4 (8%)      11 (22%)      6 (13%)     16 (33%)     17 (35%)     18 (36%)     
      Hepatocellular Adenoma, Multiple                 1 (2%)      22 (44%)     12 (25%)     48 (98%)     41 (84%)     42 (84%)     
      Hepatocellular Adenoma, Single                   8 (16%)      9 (18%)     18 (38%)                   5 (10%)      6 (12%)     
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)                                             
      Ito Cell Tumor Malignant, Multiple                            1 (2%)                                                          
      Sarcoma                                                       2 (4%)                    1 (2%)                    1 (2%)      
   Mesentery                                          (5)          (3)                                                 (2)          
   Pancreas                                           (50)         (50)         (47)         (49)         (49)         (48)         
   Salivary Glands                                    (50)         (49)         (49)         (49)         (50)         (49)         
   Stomach, Forestomach                               (48)         (49)         (47)         (50)         (49)         (47)         
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (48)         (48)         (47)         (50)         (49)         (47)         
      Adenoma                                          1 (2%)                                                                       
   Tongue                                                          (1)                                                              
      Squamous Cell Carcinoma                                       1 (100%)                                                        
   Tooth                                                           (4)          (4)          (3)          (6)          (1)          
                                                             Page  10                                                               
NTP Experiment-Test: 05077-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)         (49)         (50)         (50)         (50)         
      Hemangiosarcoma                                  1 (2%)       1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (39)         (50)         (48)         (49)         (50)         (50)         
   Adrenal Gland, Cortex                              (39)         (50)         (47)         (49)         (50)         (50)         
   Adrenal Gland, Medulla                             (38)         (50)         (47)         (49)         (49)         (50)         
      Pheochromocytoma Benign                          2 (5%)       2 (4%)       2 (4%)       1 (2%)                    1 (2%)      
      Bilateral, Pheochromocytoma Benign                                                      1 (2%)       1 (2%)                   
   Parathyroid Gland                                  (45)         (48)         (46)         (48)         (47)         (45)         
   Pituitary Gland                                    (44)         (44)         (45)         (46)         (44)         (41)         
      Pars Distalis, Adenoma                                                                                            1 (2%)      
   Thyroid Gland                                      (50)         (49)         (47)         (49)         (48)         (48)         
      Follicular Cell, Adenoma                         1 (2%)                                                           5 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (48)         (50)         (49)         (50)         
   Prostate                                           (50)         (50)         (48)         (49)         (49)         (49)         
   Seminal Vesicle                                    (1)                       (1)          (2)                                    
   Testes                                             (50)         (50)         (49)         (50)         (49)         (50)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (49)         (50)         (49)         
      Femoral, Hemangiosarcoma                         2 (4%)                                 2 (4%)                                
      Sternal, Hemangiosarcoma                         1 (2%)                                 1 (2%)       1 (2%)                   
   Lymph Node                                         (48)         (50)         (48)         (48)         (48)         (46)         
   Lymph Node, Mesenteric                             (32)         (34)         (34)         (37)         (35)         (31)         
      Histiocytic Sarcoma                                           1 (3%)                    1 (3%)       1 (3%)                   
   Spleen                                             (50)         (50)         (47)         (49)         (50)         (48)         
      Hemangiosarcoma                                  3 (6%)       2 (4%)       5 (11%)      3 (6%)       1 (2%)       1 (2%)      
      Histiocytic Sarcoma                                                                     1 (2%)                                
                                                             Page  11                                                               
NTP Experiment-Test: 05077-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (29)         (40)         (40)         (37)         (29)         (25)         
      Thymoma Benign                                                             1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (49)         (49)         (50)         (49)         
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                    1 (2%)       2 (4%)                   
      Subcutaneous Tissue, Hemangioma                                                                      1 (2%)                   
      Subcutaneous Tissue, Hemangiosarcoma                                                                 2 (4%)                   
      Subcutaneous Tissue, Sarcoma                                                            2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (2)                       (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)         (50)         (49)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (50)         (50)         (50)         
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       3 (6%)       3 (6%)       3 (6%)       2 (4%)                   
      Alveolar/Bronchiolar Adenoma, Single             9 (18%)      8 (16%)      8 (16%)      6 (12%)     11 (22%)     10 (20%)     
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)       2 (4%)                    1 (2%)                                
      Alveolar/Bronchiolar Carcinoma, Single           2 (4%)       2 (4%)       1 (2%)                                             
      Hepatoblastoma, Metastatic, Uncertain                                                                                         
          Primary Site                                              1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic             1 (2%)                    1 (2%)                    2 (4%)       4 (8%)      
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       4 (8%)                    3 (6%)       2 (4%)       5 (10%)     
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Nose                                               (50)         (50)         (49)         (50)         (50)         (50)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (4)          (5)          (1)          (1)          (3)          
      Adenoma                                          2 (67%)      3 (75%)      5 (100%)                  1 (100%)     3 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  12                                                               
NTP Experiment-Test: 05077-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)         (49)         (48)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Hepatoblastoma, Metastatic, Uncertain                                                                                         
          Primary Site                                              1 (2%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (48)         (48)         (48)         (50)         
      Hemangiosarcoma                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(49)        *(50)        *(50)        *(50)         
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)       1 (2%)       1 (2%)                   
      Lymphoma Malignant Histiocytic                                             1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   3 (6%)       3 (6%)                                 1 (2%)       1 (2%)      
      Lymphoma Malignant Mixed                         1 (2%)       1 (2%)                                              1 (2%)      
      Lymphoma Malignant Undifferentiated Cell         6 (12%)      5 (10%)      6 (12%)      4 (8%)       8 (16%)      1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  13                                                               
NTP Experiment-Test: 05077-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            37          47          42          48          47          49               
     Total Primary Neoplasms                           59          91          76         111         112         115               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 21          37          37          48          47          48               
     Total Benign Neoplasms                            26          47          50          59          62          68               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          29          20          34          37          44               
     Total Malignant Neoplasms                         33          44          26          52          50          47               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           5           1           3           4           9               
     Total Metastatic Neoplasm                          3           7           1           3           4           9               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           2                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  14                                                               
NTP Experiment-Test: 05077-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Natural Death                                     34           29                                                               
    Moribund Sacrifice                                16           21                                                               
  Survivors                                                                                                                         
  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (50)         (50)                                                             
      Hepatocellular Carcinoma, Multiple              22 (44%)     17 (34%)                                                         
      Hepatocellular Carcinoma, Single                14 (28%)     18 (36%)                                                         
      Hepatocellular Adenoma                           1 (2%)                                                                       
      Hepatocellular Adenoma, Multiple                37 (74%)     43 (86%)                                                         
      Hepatocellular Adenoma, Single                   4 (8%)       5 (10%)                                                         
   Stomach, Forestomach                               (50)         (50)                                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)         (46)                                                             
   Thyroid Gland                                      (46)         (45)                                                             
      Follicular Cell, Adenoma                         1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  15                                                               
NTP Experiment-Test: 05077-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mesenteric                             (11)         (10)                                                             
   Spleen                                             (49)         (48)                                                             
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (46)                                                             
      Alveolar/Bronchiolar Adenoma, Single             1 (2%)       3 (7%)                                                          
      Alveolar/Bronchiolar Carcinoma, Single           1 (2%)       1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic             5 (10%)      1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       5 (11%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (1)                                                              
      Adenoma                                                       1 (100%)                                                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)                                                             
      Lymphoma Malignant Lymphocytic                   2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  16                                                               
NTP Experiment-Test: 05077-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 09:16:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          50                                                               
     Total Primary Neoplasms                           85          91                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 42          48                                                               
     Total Benign Neoplasms                            45          54                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              37          35                                                               
     Total Malignant Neoplasms                         40          37                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6           6                                                               
     Total Metastatic Neoplasm                          6           6                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  17                                                               
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.