TDMS Study 05077-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus FIREMASTER FF-1 POLYBROMINATED BIPHENYL DATE: 09/10/94
EXPERIMENT: 05077 TEST: 02 TIME: 09:42:39
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-82151 ROUTE: DOSED FEED NTP C#: 53634B
PATHOLOGIST: M. RYAN S. EUSTIS CAS: 67774327
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus FIREMASTER FF-1 POLYBROMINATED BIPHENYL DATE: 09/10/94
EXPERIMENT: 05077 TEST: 02 TIME: 09:42:39
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-82151 ROUTE: DOSED FEED NTP C#: 53634B
PATHOLOGIST: M. RYAN S. EUSTIS CAS: 67774327
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus FIREMASTER FF-1 POLYBROMINATED BIPHENYL DATE: 09/10/94
EXPERIMENT: 05077 TEST: 02 TIME: 09:42:39
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-82151 ROUTE: DOSED FEED NTP C#: 53634B
PATHOLOGIST: M. RYAN S. EUSTIS CAS: 67774327
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF FIREMASTER FF-1 POLYBROMINATED BIPHEN
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Harderian Gland Adenoma
Liver Hemangiosarcoma
Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Spleen Hemangiosarcoma
Thyroid Gland: Follicular Cell
Adenoma
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus FIREMASTER FF-1 POLYBROMINATED BIPHENYL DATE: 09/10/94
EXPERIMENT: 05077 TEST: 02 TIME: 09:42:39
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-82151 ROUTE: DOSED FEED NTP C#: 53634B
PATHOLOGIST: M. RYAN S. EUSTIS CAS: 67774327
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF FIREMASTER FF-1 POLYBROMINATED BIPHEN
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Bone Marrow Hemangiosarcoma
Harderian Gland Adenoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
Histiocytic Sarcoma
Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/88 (5%) 2/47 (4%) 4/148 (3%) 0/95 (0%) | 1/99 (1%) 0/50 (0%) 0/148 (0%) 1/90 (1%) |
|ADJUSTED (b) | 6.7% 4.9% 4.0% 0.0% | 1.2% 0.0% 0.0% 1.2% |
|TERMINAL (d) | 2/53 (4%) 2/41 (5%) 3/97 (3%) 0/0 | 1/84 (1%) 0/32 (0%) 0/87 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 714 727 (T) 708 --- | 729 (T) --- --- 470 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.483N P=0.490N P=0.335N (e) | P=0.352 P=0.692N P=0.493N P=0.460 |
|INCIDENTAL TUMOR | P=0.164N P=0.663 P=0.353N P=0.225N | P=0.802 P=0.692N P=0.493N P=0.906 |
|LOGISTIC REGRESSION | P=0.307N P=0.521N P=0.311N P=0.760N | P=0.748 P=0.692N P=0.493N P=0.822N |
|COCHRAN-ARMITAGE | P=0.038N* | P=0.560 |
|FISHER EXACT | P=0.653N P=0.342N P=0.052N | P=0.664N P=0.401N P=0.727 |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 0/49 (0%) 3/148 (2%) 0/100 (0%) | 0/100 (0%) 3/50 (6%) 4/150 (3%) 0/98 (0%) |
|ADJUSTED (b) | 2.7% 0.0% 2.7% 0.0% | 0.0% 8.4% 3.6% 0.0% |
|TERMINAL (d) | 0/63 (0%) 0/42 (0%) 0/97 (0%) 0/0 | 0/84 (0%) 2/32 (6%) 1/88 (1%) 0/0 |
|FIRST INCIDENCE (DAYS) | 658 --- 604 --- | --- 621 640 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.711N P=0.362N P=0.660N P=0.813N | P=0.487 P=0.020 * P=0.103 (e) |
|INCIDENTAL TUMOR | P=0.117N P=0.778N P=0.671N P=0.237N | P=0.284N P=0.049 * P=0.301 (e) |
|LOGISTIC REGRESSION | P=0.303N P=0.407N P=0.672 P=0.426N | P=0.354N P=0.032 * P=0.138 (e) |
|COCHRAN-ARMITAGE | P=0.235N | P=0.231N |
|FISHER EXACT | P=0.449N P=0.678 P=0.249N | P=0.036 * P=0.128 (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/100 (5%) 5/49 (10%) 4/150 (3%) 1/100 (1%) | 4/100 (4%) 4/50 (8%) 4/150 (3%) 0/98 (0%) |
|ADJUSTED (b) | 7.4% 11.5% 3.9% 3.1% | 4.7% 11.2% 4.5% 0.0% |
|TERMINAL (d) | 3/63 (5%) 4/42 (10%) 3/97 (3%) 0/0 | 3/84 (4%) 2/32 (6%) 4/88 (5%) 0/0 |
|FIRST INCIDENCE (DAYS) | 665 605 684 625 | 723 624 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.602N P=0.341 P=0.251N P=0.428 | P=0.566N P=0.162 P=0.614N (e) |
|INCIDENTAL TUMOR | P=0.105N P=0.176 P=0.267N P=0.341N | P=0.172N P=0.402 P=0.510N P=0.464N |
|LOGISTIC REGRESSION | P=0.153N P=0.221 P=0.258N P=0.561N | P=0.280N P=0.230 P=0.586N P=1.000N |
|COCHRAN-ARMITAGE | P=0.032N* | P=0.024N* |
|FISHER EXACT | P=0.197 P=0.263N P=0.106N | P=0.254 P=0.405N P=0.063N |
|=================================================================================================================================|
| |
|Heart |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 0/49 (0%) 1/150 (1%) 0/96 (0%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/90 (0%) |
|ADJUSTED (b) | 2.8% 0.0% 1.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/62 (2%) 0/42 (0%) 1/97 (1%) 0/0 | 0/84 (0%) 0/32 (0%) 0/88 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 655 --- 727 (T) --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.590N P=0.353N P=0.351N P=0.826N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.395N P=0.501N P=0.358N P=0.500N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.350N P=0.401N P=0.356N P=0.490N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.228N | (e) |
|FISHER EXACT | P=0.446N P=0.348N P=0.256N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Intestine Small |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 1/49 (2%) 0/150 (0%) 0/100 (0%) | 1/100 (1%) 0/50 (0%) 2/150 (1%) 0/98 (0%) |
|ADJUSTED (b) | 1.6% 2.4% 0.0% 0.0% | 1.2% 0.0% 2.3% 0.0% |
|TERMINAL (d) | 1/63 (2%) 1/42 (2%) 0/97 (0%) 0/0 | 1/84 (1%) 0/32 (0%) 2/88 (2%) 0/0 |
|FIRST INCIDENCE (DAYS) | 727 (T) 727 (T) --- --- | 729 (T) --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.632N P=0.668 P=0.414N (e) | P=0.706 P=0.692N P=0.516 (e) |
|INCIDENTAL TUMOR | P=0.632N P=0.668 P=0.414N (e) | P=0.706 P=0.692N P=0.516 (e) |
|LOGISTIC REGRESSION | P=0.632N P=0.668 P=0.414N (e) | P=0.706 P=0.692N P=0.516 (e) |
|COCHRAN-ARMITAGE | P=0.260N | P=0.407N |
|FISHER EXACT | P=0.551 P=0.400N P=0.500N | P=0.667N P=0.649 P=0.505N |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/100 (8%) 3/48 (6%) 10/148 (7%) 0/100 (0%) | 0/100 (0%) 1/50 (2%) 5/150 (3%) 0/95 (0%) |
|ADJUSTED (b) | 11.8% 6.9% 8.9% 0.0% | 0.0% 3.1% 4.6% 0.0% |
|TERMINAL (d) | 5/63 (8%) 2/42 (5%) 4/97 (4%) 0/0 | 0/84 (0%) 1/32 (3%) 2/88 (2%) 0/0 |
|FIRST INCIDENCE (DAYS) | 658 605 561 --- | --- 729 (T) 624 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.335N P=0.311N P=0.416N P=0.836N | P=0.209 P=0.308 P=0.059 (e) |
|INCIDENTAL TUMOR | P=0.006N** P=0.554N P=0.396N P=0.118N | P=0.709N P=0.308 P=0.166 (e) |
|LOGISTIC REGRESSION | P=0.021N* P=0.442N P=0.450N P=0.253N | P=0.717N P=0.308 P=0.088 (e) |
|COCHRAN-ARMITAGE | P=0.006N** | P=0.422N |
|FISHER EXACT | P=0.496N P=0.447N P=0.003N** | P=0.333 P=0.076 (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 40/100 (40%) 30/48 (63%) 142/148 (96%) 90/100 (90%)| 23/100 (23%) 6/50 (12%) 124/150 (83%) 87/95 (92%) |
|ADJUSTED (b) | 53.9% 66.6% 99.3% 100.0% | 26.4% 17.5% 93.1% 100.0% |
|TERMINAL (d) | 30/63 (48%) 27/42 (64%) 96/97 (99%) 0/0 | 20/84 (24%) 5/32 (16%) 79/88 (90%) 0/0 |
|FIRST INCIDENCE (DAYS) | 531 307 391 314 | 620 621 435 291 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.250 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.231N P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.040 * P<0.001 ** P<0.001 ** | P<0.001 ** P=0.098N P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.016 * P<0.001 ** P<0.001 ** | P<0.001 ** P=0.128N P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.008 ** P<0.001 ** P<0.001 ** | P=0.080N P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/100 (25%) 8/48 (17%) 101/148 (68%) 71/100 (71%)| 5/100 (5%) 2/50 (4%) 92/150 (61%) 64/95 (67%) |
|ADJUSTED (b) | 32.6% 19.0% 80.5% 100.0% | 5.9% 5.3% 70.8% 97.1% |
|TERMINAL (d) | 14/63 (22%) 8/42 (19%) 73/97 (75%) 0/0 | 4/84 (5%) 1/32 (3%) 51/88 (58%) 0/0 |
|FIRST INCIDENCE (DAYS) | 447 727 (T) 391 314 | 708 621 435 291 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.051N P<0.001 ** P<0.001 ** | P<0.001 ** P=0.662 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.263N P<0.001 ** P<0.001 ** | P<0.001 ** P=0.467N P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.162N P<0.001 ** P<0.001 ** | P<0.001 ** P=0.581N P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.177N P<0.001 ** P<0.001 ** | P=0.571N P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 56/100 (56%) 31/48 (65%) 142/148 (96%) 98/100 (98%)| 26/100 (26%) 8/50 (16%) 136/150 (91%) 94/95 (99%) |
|ADJUSTED (b) | 68.5% 68.8% 99.3% 100.0% | 29.8% 22.4% 97.1% 100.0% |
|TERMINAL (d) | 38/63 (60%) 28/42 (67%) 96/97 (99%) 0/0 | 23/84 (27%) 6/32 (19%) 84/88 (95%) 0/0 |
|FIRST INCIDENCE (DAYS) | 447 307 391 314 | 620 621 435 291 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.232N P<0.001 ** P<0.001 ** | P<0.001 ** P=0.327N P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.307 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.133N P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.261 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.179N P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.208 P<0.001 ** P<0.001 ** | P=0.119N P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 56/100 (56%) 31/48 (65%) 142/148 (96%) 98/100 (98%)| 26/100 (26%) 8/50 (16%) 136/150 (91%) 94/95 (99%) |
|ADJUSTED (b) | 68.5% 68.8% 99.3% 100.0% | 29.8% 22.4% 97.1% 100.0% |
|TERMINAL (d) | 38/63 (60%) 28/42 (67%) 96/97 (99%) 0/0 | 23/84 (27%) 6/32 (19%) 84/88 (95%) 0/0 |
|FIRST INCIDENCE (DAYS) | 447 307 391 314 | 620 621 435 291 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.232N P<0.001 ** P<0.001 ** | P<0.001 ** P=0.327N P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.307 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.133N P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.261 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.179N P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.208 P<0.001 ** P<0.001 ** | P=0.119N P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Liver |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 0/48 (0%) 2/148 (1%) 0/100 (0%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/95 (0%) |
|ADJUSTED (b) | 2.9% 0.0% 1.7% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/63 (2%) 0/42 (0%) 1/97 (1%) 0/0 | 0/84 (0%) 0/32 (0%) 0/88 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 678 --- 421 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.546N P=0.350N P=0.535N P=0.898N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.173N P=0.503N P=0.638N P=0.500N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.182N P=0.400N P=0.537N P=0.597N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.230N | (e) |
|FISHER EXACT | P=0.455N P=0.531N P=0.249N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 21/100 (21%) 11/49 (22%) 32/150 (21%) 4/96 (4%) | 2/100 (2%) 2/50 (4%) 6/150 (4%) 2/90 (2%) |
|ADJUSTED (b) | 29.9% 25.0% 30.7% 6.3% | 2.3% 5.9% 6.2% 15.4% |
|TERMINAL (d) | 16/63 (25%) 9/42 (21%) 27/97 (28%) 0/0 | 1/84 (1%) 1/32 (3%) 4/88 (5%) 0/0 |
|FIRST INCIDENCE (DAYS) | 531 662 475 440 | 708 692 651 477 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.118 P=0.344N P=0.547N P=0.287 | P=0.006 ** P=0.336 P=0.181 P=0.040 * |
|INCIDENTAL TUMOR | P=0.085N P=0.553 P=0.498 P=0.036N* | P=0.441 P=0.594 P=0.407 P=0.620N |
|LOGISTIC REGRESSION | P=0.031N* P=0.563 P=0.551 P=0.011N* | P=0.361 P=0.614 P=0.278 P=0.594 |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.523N |
|FISHER EXACT | P=0.498 P=0.540 P<0.001N** | P=0.407 P=0.312 P=0.649 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/100 (7%) 1/49 (2%) 1/150 (1%) 2/96 (2%) | 2/100 (2%) 3/50 (6%) 2/150 (1%) 0/90 (0%) |
|ADJUSTED (b) | 10.4% 2.4% 1.0% 35.7% | 2.2% 8.4% 2.1% 0.0% |
|TERMINAL (d) | 4/63 (6%) 1/42 (2%) 0/97 (0%) 0/0 | 1/84 (1%) 2/32 (6%) 1/88 (1%) 0/0 |
|FIRST INCIDENCE (DAYS) | 698 727 (T) 723 635 | 451 621 697 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.513 P=0.113N P=0.007N** P=0.021 * | P=0.436N P=0.159 P=0.631N P=0.535N |
|INCIDENTAL TUMOR | P=0.182N P=0.252N P=0.008N** P=0.378N | P=0.051N P=0.207 P=0.576N P=0.116N |
|LOGISTIC REGRESSION | P=0.467N P=0.147N P=0.007N** P=0.539 | P=0.058N P=0.268 P=0.508N P=0.089N |
|COCHRAN-ARMITAGE | P=0.121N | P=0.089N |
|FISHER EXACT | P=0.195N P=0.008N** P=0.095N | P=0.207 P=0.525N P=0.276N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 28/100 (28%) 12/49 (24%) 33/150 (22%) 6/96 (6%) | 4/100 (4%) 5/50 (10%) 8/150 (5%) 2/90 (2%) |
|ADJUSTED (b) | 38.6% 27.3% 31.4% 39.8% | 4.5% 14.0% 8.2% 15.4% |
|TERMINAL (d) | 20/63 (32%) 10/42 (24%) 27/97 (28%) 0/0 | 2/84 (2%) 3/32 (9%) 5/88 (6%) 0/0 |
|FIRST INCIDENCE (DAYS) | 531 662 475 440 | 451 621 651 477 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.094 P=0.125N P=0.149N P=0.049 * | P=0.075 P=0.080 P=0.257 P=0.241 |
|INCIDENTAL TUMOR | P=0.031N* P=0.405N P=0.200N P=0.027N* | P=0.271N P=0.208 P=0.509 P=0.186N |
|LOGISTIC REGRESSION | P=0.023N* P=0.319N P=0.162N P=0.021N* | P=0.329N P=0.159 P=0.439 P=0.350N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.160N |
|FISHER EXACT | P=0.402N P=0.176N P<0.001N** | P=0.138 P=0.436 P=0.392N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/49 (0%) 0/150 (0%) 0/100 (0%) | 0/100 (0%) 2/50 (4%) 1/150 (1%) 0/98 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 5.5% 1.1% 0.0% |
|TERMINAL (d) | 0/63 (0%) 0/42 (0%) 0/97 (0%) 0/0 | 0/84 (0%) 1/32 (3%) 1/88 (1%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 640 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.860 P=0.078 P=0.509 (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.452N P=0.185 P=0.509 (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.585N P=0.109 P=0.509 (e) |
|COCHRAN-ARMITAGE | (e) | P=0.329N |
|FISHER EXACT | (e) (e) (e) | P=0.110 P=0.600 (e) |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/96 (2%) 0/48 (0%) 1/146 (1%) 0/91 (0%) |
|ADJUSTED (b) | | 2.4% 0.0% 1.2% 0.0% |
|TERMINAL (d) | | 2/83 (2%) 0/32 (0%) 1/86 (1%) 0/0 |
|FIRST INCIDENCE (DAYS) | | 729 (T) --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.763N P=0.464N P=0.488N (e) |
|INCIDENTAL TUMOR | | P=0.763N P=0.464N P=0.488N (e) |
|LOGISTIC REGRESSION | | P=0.763N P=0.464N P=0.488N (e) |
|COCHRAN-ARMITAGE | | P=0.232N |
|FISHER EXACT | | P=0.443N P=0.347N P=0.262N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Ovary |
| Luteoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 1/96 (1%) 1/48 (2%) 2/146 (1%) 0/91 (0%) |
|ADJUSTED (b) | | 1.2% 3.1% 1.9% 0.0% |
|TERMINAL (d) | | 1/83 (1%) 1/32 (3%) 1/86 (1%) 0/0 |
|FIRST INCIDENCE (DAYS) | | 729 (T) 729 (T) 563 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.785 P=0.536 P=0.558 (e) |
|INCIDENTAL TUMOR | | P=0.503N P=0.536 P=0.679 (e) |
|LOGISTIC REGRESSION | | P=0.428N P=0.536 P=0.669 (e) |
|COCHRAN-ARMITAGE | | P=0.287N |
|FISHER EXACT | | P=0.557 P=0.653 P=0.513N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/88 (0%) 0/45 (0%) 1/131 (1%) 0/75 (0%) | 11/95 (12%) 10/49 (20%) 24/139 (17%) 0/74 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 1.1% 0.0% | 13.4% 30.0% 25.2% 0.0% |
|TERMINAL (d) | 0/55 (0%) 0/40 (0%) 1/87 (1%) 0/0 | 11/82 (13%) 9/32 (28%) 16/83 (19%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 727 (T) --- | 729 (T) 677 653 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.887 (e) P=0.591 (e) | P=0.069 P=0.029 * P=0.023 * (e) |
|INCIDENTAL TUMOR | P=0.887 (e) P=0.591 (e) | P=0.508 P=0.039 * P=0.122 (e) |
|LOGISTIC REGRESSION | P=0.887 (e) P=0.591 (e) | P=0.566 P=0.043 * P=0.070 (e) |
|COCHRAN-ARMITAGE | P=0.797N | P=0.002N** |
|FISHER EXACT | (e) P=0.598 (e) | P=0.121 P=0.156 P=0.001N** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 0/49 (0%) 3/150 (2%) 0/100 (0%) | 1/100 (1%) 2/50 (4%) 0/150 (0%) 0/98 (0%) |
|ADJUSTED (b) | 1.2% 0.0% 3.0% 0.0% | 1.1% 6.3% 0.0% 0.0% |
|TERMINAL (d) | 0/63 (0%) 0/42 (0%) 2/97 (2%) 0/0 | 0/84 (0%) 2/32 (6%) 0/88 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 652 --- 709 --- | 612 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.623 P=0.622N P=0.472 P=0.817N | P=0.481N P=0.214 P=0.417N P=0.837N |
|INCIDENTAL TUMOR | P=0.588N P=0.916N P=0.454 P=0.500N | P=0.196N P=0.347 P=0.205N P=0.134N |
|LOGISTIC REGRESSION | P=0.674N P=0.643N P=0.461 P=0.602N | P=0.203N P=0.275 P=0.385N P=0.492N |
|COCHRAN-ARMITAGE | P=0.385N | P=0.170N |
|FISHER EXACT | P=0.671N P=0.475 P=0.500N | P=0.258 P=0.400N P=0.505N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/49 (0%) 2/150 (1%) 0/100 (0%) | 0/100 (0%) 1/50 (2%) 3/150 (2%) 0/98 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 1.7% 0.0% | 0.0% 2.3% 3.1% 0.0% |
|TERMINAL (d) | 0/63 (0%) 0/42 (0%) 0/97 (0%) 0/0 | 0/84 (0%) 0/32 (0%) 2/88 (2%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 631 --- | --- 621 654 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.643 (e) P=0.342 (e) | P=0.463 P=0.360 P=0.148 (e) |
|INCIDENTAL TUMOR | P=0.439N (e) P=0.374 (e) | P=0.626N P=0.612 P=0.222 (e) |
|LOGISTIC REGRESSION | P=0.760N (e) P=0.332 (e) | P=0.663N P=0.417 P=0.198 (e) |
|COCHRAN-ARMITAGE | P=0.662N | P=0.445N |
|FISHER EXACT | (e) P=0.359 (e) | P=0.333 P=0.214 (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 0/49 (0%) 5/150 (3%) 0/100 (0%) | 1/100 (1%) 2/50 (4%) 0/150 (0%) 0/98 (0%) |
|ADJUSTED (b) | 1.2% 0.0% 4.6% 0.0% | 1.1% 6.3% 0.0% 0.0% |
|TERMINAL (d) | 0/63 (0%) 0/42 (0%) 2/97 (2%) 0/0 | 0/84 (0%) 2/32 (6%) 0/88 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 652 --- 607 --- | 612 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.442 P=0.622N P=0.236 P=0.817N | P=0.481N P=0.214 P=0.417N P=0.837N |
|INCIDENTAL TUMOR | P=0.360N P=0.916N P=0.240 P=0.500N | P=0.196N P=0.347 P=0.205N P=0.134N |
|LOGISTIC REGRESSION | P=0.550N P=0.643N P=0.224 P=0.602N | P=0.203N P=0.275 P=0.385N P=0.492N |
|COCHRAN-ARMITAGE | P=0.360N | P=0.170N |
|FISHER EXACT | P=0.671N P=0.230 P=0.500N | P=0.258 P=0.400N P=0.505N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 0/49 (0%) 5/150 (3%) 0/100 (0%) | 1/100 (1%) 2/50 (4%) 0/150 (0%) 0/98 (0%) |
|ADJUSTED (b) | 1.2% 0.0% 4.6% 0.0% | 1.1% 6.3% 0.0% 0.0% |
|TERMINAL (d) | 0/63 (0%) 0/42 (0%) 2/97 (2%) 0/0 | 0/84 (0%) 2/32 (6%) 0/88 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 652 --- 607 --- | 612 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.442 P=0.622N P=0.236 P=0.817N | P=0.481N P=0.214 P=0.417N P=0.837N |
|INCIDENTAL TUMOR | P=0.360N P=0.916N P=0.240 P=0.500N | P=0.196N P=0.347 P=0.205N P=0.134N |
|LOGISTIC REGRESSION | P=0.550N P=0.643N P=0.224 P=0.602N | P=0.203N P=0.275 P=0.385N P=0.492N |
|COCHRAN-ARMITAGE | P=0.360N | P=0.170N |
|FISHER EXACT | P=0.671N P=0.230 P=0.500N | P=0.258 P=0.400N P=0.505N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/49 (0%) 2/150 (1%) 0/100 (0%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/98 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 1.7% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/63 (0%) 0/42 (0%) 0/97 (0%) 0/0 | 0/84 (0%) 0/32 (0%) 0/88 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 607 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.662 (e) P=0.337 (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.439N (e) P=0.374 (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.695N (e) P=0.335 (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.662N | (e) |
|FISHER EXACT | (e) P=0.359 (e) | (e) (e) (e) |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/100 (5%) 5/47 (11%) 5/147 (3%) 2/97 (2%) | 2/98 (2%) 2/50 (4%) 7/150 (5%) 0/91 (0%) |
|ADJUSTED (b) | 7.1% 11.8% 4.6% 5.8% | 2.4% 6.3% 6.7% 0.0% |
|TERMINAL (d) | 1/63 (2%) 4/41 (10%) 1/97 (1%) 0/0 | 2/84 (2%) 2/32 (6%) 3/88 (3%) 0/0 |
|FIRST INCIDENCE (DAYS) | 658 605 604 587 | 729 (T) 729 (T) 640 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.380 P=0.332 P=0.351N P=0.153 | P=0.266 P=0.327 P=0.129 (e) |
|INCIDENTAL TUMOR | P=0.045N* P=0.065 P=0.383N P=0.147N | P=0.564N P=0.327 P=0.367 (e) |
|LOGISTIC REGRESSION | P=0.082N P=0.197 P=0.381N P=0.623N | P=0.649N P=0.327 P=0.225 (e) |
|COCHRAN-ARMITAGE | P=0.089N | P=0.149N |
|FISHER EXACT | P=0.178 P=0.377N P=0.235N | P=0.415 P=0.236 P=0.268N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 0/49 (0%) 0/150 (0%) 1/100 (1%) | 3/100 (3%) 2/50 (4%) 2/150 (1%) 1/98 (1%) |
|ADJUSTED (b) | 1.6% 0.0% 0.0% 10.0% | 3.6% 6.3% 2.1% 10.0% |
|TERMINAL (d) | 1/63 (2%) 0/42 (0%) 0/97 (0%) 0/0 | 3/84 (4%) 2/32 (6%) 0/88 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 727 (T) --- --- 676 | 729 (T) 729 (T) 715 634 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.157 P=0.581N P=0.414N P=0.118 | P=0.334 P=0.451 P=0.471N P=0.093 |
|INCIDENTAL TUMOR | P=0.438 P=0.581N P=0.414N P=0.500 | P=0.568N P=0.451 P=0.204N P=0.866 |
|LOGISTIC REGRESSION | P=0.391 P=0.581N P=0.414N P=0.414 | P=0.628 P=0.451 P=0.412N P=0.577 |
|COCHRAN-ARMITAGE | P=0.582 | P=0.203N |
|FISHER EXACT | P=0.671N P=0.400N P=0.751N | P=0.541 P=0.316N P=0.318N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 0/47 (0%) 5/145 (3%) 3/91 (3%) | 3/99 (3%) 1/50 (2%) 4/150 (3%) 0/87 (0%) |
|ADJUSTED (b) | 1.6% 0.0% 4.9% 11.4% | 3.5% 3.1% 4.5% 0.0% |
|TERMINAL (d) | 1/62 (2%) 0/41 (0%) 4/96 (4%) 0/0 | 2/84 (2%) 1/32 (3%) 4/88 (5%) 0/0 |
|FIRST INCIDENCE (DAYS) | 727 (T) --- 548 526 | 708 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.582N P=0.236 P=0.013 * | P=0.660 P=0.670N P=0.528 (e) |
|INCIDENTAL TUMOR | P=0.135 P=0.582N P=0.253 P=0.287 | P=0.738N P=0.539N P=0.642 P=0.464N |
|LOGISTIC REGRESSION | P=0.116 P=0.582N P=0.217 P=0.179 | P=0.733 P=0.624N P=0.597 P=0.930N |
|COCHRAN-ARMITAGE | P=0.198 | P=0.126N |
|FISHER EXACT | P=0.678N P=0.221 P=0.279 | P=0.589N P=0.577N P=0.149N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 1/100 (1%) 2/50 (4%) 0/150 (0%) 0/98 (0%) |
|ADJUSTED (b) | | 1.2% 6.3% 0.0% 0.0% |
|TERMINAL (d) | | 1/84 (1%) 2/32 (6%) 0/88 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | | 729 (T) 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.581N P=0.190 P=0.491N (e) |
|INCIDENTAL TUMOR | | P=0.581N P=0.190 P=0.491N (e) |
|LOGISTIC REGRESSION | | P=0.581N P=0.190 P=0.491N (e) |
|COCHRAN-ARMITAGE | | P=0.170N |
|FISHER EXACT | | P=0.258 P=0.400N P=0.505N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 2/100 (2%) 3/50 (6%) 1/150 (1%) 0/98 (0%) |
|ADJUSTED (b) | | 2.4% 8.4% 1.1% 0.0% |
|TERMINAL (d) | | 2/84 (2%) 2/32 (6%) 1/88 (1%) 0/0 |
|FIRST INCIDENCE (DAYS) | | 729 (T) 621 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.451N P=0.143 P=0.484N (e) |
|INCIDENTAL TUMOR | | P=0.205N P=0.225 P=0.484N (e) |
|LOGISTIC REGRESSION | | P=0.209N P=0.196 P=0.484N (e) |
|COCHRAN-ARMITAGE | | P=0.071N |
|FISHER EXACT | | P=0.207 P=0.351N P=0.254N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/49 (0%) 1/150 (1%) 0/100 (0%) | 1/100 (1%) 1/50 (2%) 2/150 (1%) 1/98 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 1.0% 0.0% | 1.2% 3.1% 2.3% 1.3% |
|TERMINAL (d) | 0/63 (0%) 0/42 (0%) 1/97 (1%) 0/0 | 1/84 (1%) 1/32 (3%) 2/88 (2%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 727 (T) --- | 729 (T) 729 (T) 729 (T) 477 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.885 (e) P=0.586 (e) | P=0.176 P=0.533 P=0.516 P=0.454 |
|INCIDENTAL TUMOR | P=0.885 (e) P=0.586 (e) | P=0.533 P=0.533 P=0.516 P=0.900 |
|LOGISTIC REGRESSION | P=0.885 (e) P=0.586 (e) | P=0.620 P=0.533 P=0.516 P=0.827N |
|COCHRAN-ARMITAGE | P=0.770N | P=0.584N |
|FISHER EXACT | (e) P=0.600 (e) | P=0.557 P=0.649 P=0.746 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 11/100 (11%) 7/49 (14%) 15/150 (10%) 2/100 (2%) | 2/100 (2%) 4/50 (8%) 11/150 (7%) 0/98 (0%) |
|ADJUSTED (b) | 15.7% 16.2% 13.0% 5.8% | 2.4% 11.4% 10.4% 0.0% |
|TERMINAL (d) | 6/63 (10%) 6/42 (14%) 5/97 (5%) 0/0 | 2/84 (2%) 3/32 (9%) 5/88 (6%) 0/0 |
|FIRST INCIDENCE (DAYS) | 655 605 561 587 | 729 (T) 621 624 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.464 P=0.595N P=0.450N P=0.234 | P=0.139 P=0.050 P=0.025 * (e) |
|INCIDENTAL TUMOR | P=0.005N** P=0.285 P=0.429N P=0.081N | P=0.345N P=0.087 P=0.127 (e) |
|LOGISTIC REGRESSION | P=0.009N** P=0.431 P=0.512N P=0.290N | P=0.447N P=0.079 P=0.058 (e) |
|COCHRAN-ARMITAGE | P=0.005N** | P=0.080N |
|FISHER EXACT | P=0.370 P=0.479N P=0.009N** | P=0.096 P=0.053 P=0.254N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 11/100 (11%) 7/49 (14%) 16/150 (11%) 2/100 (2%) | 3/100 (3%) 5/50 (10%) 13/150 (9%) 1/98 (1%) |
|ADJUSTED (b) | 15.7% 16.2% 14.0% 5.8% | 3.6% 14.5% 12.5% 1.3% |
|TERMINAL (d) | 6/63 (10%) 6/42 (14%) 6/97 (6%) 0/0 | 3/84 (4%) 4/32 (13%) 7/88 (8%) 0/0 |
|FIRST INCIDENCE (DAYS) | 655 605 561 587 | 729 (T) 621 624 477 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.414 P=0.595N P=0.514N P=0.234 | P=0.034 * P=0.036 * P=0.022 * P=0.454 |
|INCIDENTAL TUMOR | P=0.006N** P=0.285 P=0.498N P=0.081N | P=0.467N P=0.061 P=0.102 P=0.900 |
|LOGISTIC REGRESSION | P=0.011N* P=0.431 P=0.577N P=0.290N | P=0.513N P=0.061 P=0.059 P=0.675N |
|COCHRAN-ARMITAGE | P=0.005N** | P=0.091N |
|FISHER EXACT | P=0.370 P=0.545N P=0.009N** | P=0.082 P=0.059 P=0.318N |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 1/49 (2%) 2/150 (1%) 0/100 (0%) | 2/100 (2%) 3/50 (6%) 4/150 (3%) 0/98 (0%) |
|ADJUSTED (b) | 2.5% 2.3% 1.9% 0.0% | 2.3% 7.8% 4.0% 0.0% |
|TERMINAL (d) | 0/63 (0%) 0/42 (0%) 1/97 (1%) 0/0 | 1/84 (1%) 1/32 (3%) 2/88 (2%) 0/0 |
|FIRST INCIDENCE (DAYS) | 624 662 702 --- | 575 490 630 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.507N P=0.702N P=0.530N P=0.581N | P=0.608N P=0.165 P=0.425 P=0.736N |
|INCIDENTAL TUMOR | P=0.101N P=0.440 P=0.510N P=0.094N | P=0.041N* P=0.310 P=0.662N P=0.134N |
|LOGISTIC REGRESSION | P=0.180N P=0.728 P=0.541N P=0.268N | P=0.064N P=0.281 P=0.550 P=0.282N |
|COCHRAN-ARMITAGE | P=0.158N | P=0.090N |
|FISHER EXACT | P=0.701 P=0.525N P=0.249N | P=0.207 P=0.544 P=0.254N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 21/100 (21%) 8/49 (16%) 18/150 (12%) 2/100 (2%) | 15/100 (15%) 16/50 (32%) 17/150 (11%) 0/98 (0%) |
|ADJUSTED (b) | 26.7% 17.7% 15.3% 12.2% | 16.7% 37.3% 15.1% 0.0% |
|TERMINAL (d) | 9/63 (14%) 5/42 (12%) 6/97 (6%) 0/0 | 10/84 (12%) 6/32 (19%) 6/88 (7%) 0/0 |
|FIRST INCIDENCE (DAYS) | 554 597 548 461 | 492 490 546 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.186N P=0.159N P=0.042N* P=0.536N | P=0.141N P=0.004 ** P=0.524N P=0.378N |
|INCIDENTAL TUMOR | P<0.001N** P=0.533 P=0.020N* P<0.001N** | P<0.001N** P=0.058 P=0.059N P<0.001N** |
|LOGISTIC REGRESSION | P<0.001N** P=0.574 P=0.045N* P=0.002N** | P<0.001N** P=0.019 * P=0.228N P=0.003N** |
|COCHRAN-ARMITAGE | P<0.001N** | P<0.001N** |
|FISHER EXACT | P=0.329N P=0.042N* P<0.001N** | P=0.015 * P=0.254N P<0.001N** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 19/100 (19%) 7/49 (14%) 16/150 (11%) 2/100 (2%) | 13/100 (13%) 13/50 (26%) 13/150 (9%) 0/98 (0%) |
|ADJUSTED (b) | 24.9% 15.8% 13.6% 12.2% | 14.7% 31.6% 11.4% 0.0% |
|TERMINAL (d) | 9/63 (14%) 5/42 (12%) 5/97 (5%) 0/0 | 9/84 (11%) 5/32 (16%) 4/88 (5%) 0/0 |
|FIRST INCIDENCE (DAYS) | 554 597 548 461 | 492 512 546 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.238N P=0.151N P=0.047N* P=0.659 | P=0.141N P=0.013 * P=0.411N P=0.513N |
|INCIDENTAL TUMOR | P<0.001N** P=0.551N P=0.026N* P<0.001N** | P<0.001N** P=0.127 P=0.046N* P=0.007N** |
|LOGISTIC REGRESSION | P<0.001N** P=0.501N P=0.053N P=0.007N** | P<0.001N** P=0.043 * P=0.167N P=0.020N* |
|COCHRAN-ARMITAGE | P<0.001N** | P<0.001N** |
|FISHER EXACT | P=0.320N P=0.048N* P<0.001N** | P=0.042 * P=0.187N P<0.001N** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 58/100 (58%) 37/49 (76%) 143/150 (95%) 90/100 (90%)| 44/100 (44%) 22/50 (44%) 128/150 (85%) 87/98 (89%) |
|ADJUSTED (b) | 72.0% 80.4% 100.0% 100.0% | 49.4% 58.9% 94.0% 100.0% |
|TERMINAL (d) | 41/63 (65%) 33/42 (79%) 97/97 (100%) 0/0 | 39/84 (46%) 17/32 (53%) 80/88 (91%) 0/0 |
|FIRST INCIDENCE (DAYS) | 531 307 391 314 | 548 621 435 291 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.544N P<0.001 ** P<0.001 ** | P<0.001 ** P=0.141 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.068 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.499 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.042 * P<0.001 ** P<0.001 ** | P<0.001 ** P=0.386 P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.027 * P<0.001 ** P<0.001 ** | P=0.570N P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 53/100 (53%) 20/49 (41%) 116/150 (77%) 72/100 (72%)| 26/100 (26%) 26/50 (52%) 108/150 (72%) 64/98 (65%) |
|ADJUSTED (b) | 61.2% 43.5% 85.2% 100.0% | 28.1% 56.3% 77.0% 97.1% |
|TERMINAL (d) | 30/63 (48%) 16/42 (38%) 77/97 (79%) 0/0 | 18/84 (21%) 12/32 (38%) 56/88 (64%) 0/0 |
|FIRST INCIDENCE (DAYS) | 447 597 391 314 | 451 490 435 291 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.016N* P=0.004 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.284N P<0.001 ** P=0.071 | P<0.001 ** P=0.013 * P<0.001 ** P=0.089 |
|LOGISTIC REGRESSION | P<0.001 ** P=0.235N P<0.001 ** P<0.001 ** | P<0.001 ** P=0.005 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.110N P<0.001 ** P=0.004 ** | P=0.002 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 02 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 84/100 (84%) 42/49 (86%) 144/150 (96%) 98/100 (98%)| 60/100 (60%) 36/50 (72%) 145/150 (97%) 94/98 (96%) |
|ADJUSTED (b) | 90.3% 89.4% 100.0% 100.0% | 63.8% 78.1% 98.6% 100.0% |
|TERMINAL (d) | 54/63 (86%) 37/42 (88%) 97/97 (100%) 0/0 | 50/84 (60%) 22/32 (69%) 86/88 (98%) 0/0 |
|FIRST INCIDENCE (DAYS) | 447 307 391 314 | 451 490 435 291 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.027N* P=0.123 P<0.001 ** | P<0.001 ** P=0.006 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.459 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.160 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.531 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.077 P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.496 P=0.001 ** P<0.001 ** | P=0.103 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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