TDMS Study 05077-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/10/94
EXP: 05077 FIREMASTER FF-1 POLYBROMINATED BIPHENYL TIME: 09:43:18
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 53634B
CONT: NO1-ES-82151 CAS: 67774327
PATHOLOGIST: M. RYAN S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
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REMOVAL DATE RANGE:
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/10/94
EXP: 05077 FIREMASTER FF-1 POLYBROMINATED BIPHENYL TIME: 09:43:18
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 53634B
CONT: NO1-ES-82151 CAS: 67774327
PATHOLOGIST: M. RYAN S. EUSTIS
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM 0-0 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 268 447 531 531 531 535 541 545 554 632 |
| 648 658 667 683 691 704 705 707 714 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0 PPM 10-0 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 244 485 516 581 607 617 624 632 652 655 |
| 665 670 678 695 698 711 719 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3 PPM 1-1 |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 79 307 468 597 605 662 712 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 10 PPM 0-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 160 505 560 561 587 604 604 607 667 687 |
| 702 706 716 720 723 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM 3-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 122 183 415 475 575 611 631 640 653 684 |
| 692 708 709 716 719 720 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM 10-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 138 391 421 541 548 559 559 562 591 598 |
| 651 653 662 670 671 672 684 694 702 716 |
| 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 30 PPM 0-10 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 50 CENSORED DEATHS 0 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 404 420 450 461 464 475 477 496 510 513 |
| 530 531 531 531 540 573 573 580 582 587 |
| 591 599 609 609 613 625 636 636 641 641 |
| 642 648 649 650 654 655 659 662 664 665 |
| 676 679 682 688 694 699 700 703 704 706 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 PPM 10-10 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 50 CENSORED DEATHS 0 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 314 342 345 349 353 363 363 372 373 374 |
| 384 400 440 445 461 468 470 493 494 496 |
| 498 500 501 508 512 513 519 524 526 531 |
| 531 531 545 548 565 572 572 572 574 580 |
| 608 622 623 625 627 631 635 636 639 639 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 727 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM 0-0| 100.0 100.0 98.0 98.0 98.0 96.0 84.0 82.0 76.0 62.0 |
| | |
| | |
|0 | 100.0 100.0 98.0 98.0 98.0 96.0 94.0 92.0 78.0 64.0 |
|PPM 10-0 | |
| | |
|3 PPM 1-1| 98.0 98.0 98.0 95.9 95.9 93.9 93.9 89.8 87.8 85.7 |
| | |
| | |
|10 | 100.0 98.0 98.0 98.0 98.0 98.0 96.0 86.0 84.0 68.0 |
|PPM 0-3 | |
| | |
|10 | 100.0 98.0 96.0 96.0 94.0 92.0 92.0 90.0 82.0 68.0 |
|PPM 3-3 | |
| | |
|10 | 100.0 98.0 98.0 98.0 94.0 94.0 92.0 80.0 74.0 58.0 |
|PPM 10-3 | |
| | |
|30 | 100.0 100.0 100.0 100.0 96.0 86.0 70.0 56.0 20.0 0.0 |
|PPM 0-10 | |
| | |
|30 | 100.0 100.0 100.0 86.0 76.0 66.0 34.0 20.0 0.0 0.0 |
|PPM 10-10| |
| | |
==================================================================================
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 0-0 0 3 PPM 1-1 10 10 10 30 30 |
| PPM 10-0 PPM 0-3 PPM 3-3 PPM 10-3 PPM 0-10 PPM 10-|0
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.0% 64.0% 85.7% 68.0% 68.0% 58.0% 0.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 ----- P=0.017N P=0.538N P=0.585N P=0.853 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 594.3 620.6 490.0 614.5 578.3 590.9 598.1 502.1 |
|NATURAL DEATHS (C) | (26.1) (27.0) (85.4) (35.0) (47.1) (30.0) (11.8) (13.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 676.6 688.7 693.1 691.0 679.4 669.8 598.1 502.1 |
|(STANDARD ERROR) | (13.4) (12.0) (16.5) (13.3) (17.8) (15.7) (11.8) (13.6) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM 0-0 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 428 451 533 533 533 548 575 612 647 687 |
| 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0 PPM 10-0 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 491 492 620 708 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3 PPM 1-1 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 309 341 490 512 603 603 621 621 624 627 |
| 640 673 677 680 687 692 710 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 10 PPM 0-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 540 617 629 630 640 650 661 662 666 694 |
| 704 707 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM 3-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 194 563 575 621 624 624 638 653 654 667 |
| 692 694 699 701 703 718 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM 10-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 33 CENSORED DEATHS 0 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 435 509 531 546 554 555 610 611 617 617 |
| 627 636 645 648 651 651 656 667 676 680 |
| 684 688 692 692 697 703 703 706 715 717 |
| 717 725 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 30 PPM 0-10 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 50 CENSORED DEATHS 0 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 359 365 440 470 484 484 485 491 505 505 |
| 506 508 513 515 515 519 519 529 530 532 |
| 533 533 533 544 561 573 575 575 576 580 |
| 589 592 595 595 599 606 617 620 622 633 |
| 634 635 636 641 652 660 671 678 683 683 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 PPM 10-10 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 50 CENSORED DEATHS 0 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 291 312 347 350 364 369 389 389 401 402 |
| 403 411 442 445 454 463 463 470 477 480 |
| 484 489 495 498 501 502 506 512 512 512 |
| 515 515 515 519 519 519 520 533 533 533 |
| 533 537 538 554 557 571 592 606 619 620 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM 0-0| 100.0 100.0 100.0 100.0 100.0 96.0 90.0 86.0 82.0 78.0 |
| | |
| | |
|0 | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 96.0 94.0 90.0 |
|PPM 10-0 | |
| | |
|3 PPM 1-1| 100.0 100.0 100.0 96.0 96.0 96.0 92.0 88.0 78.0 64.0 |
| | |
| | |
|10 | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 98.0 84.0 76.0 |
|PPM 0-3 | |
| | |
|10 | 100.0 100.0 98.0 98.0 98.0 98.0 98.0 94.0 82.0 66.0 |
|PPM 3-3 | |
| | |
|10 | 100.0 100.0 100.0 100.0 100.0 98.0 94.0 88.0 66.0 34.0 |
|PPM 10-3 | |
| | |
|30 | 100.0 100.0 100.0 96.0 96.0 86.0 52.0 30.0 8.0 0.0 |
|PPM 0-10 | |
| | |
|30 | 100.0 100.0 100.0 90.0 76.0 58.0 14.0 6.0 0.0 0.0 |
|PPM 10-10| |
| | |
==================================================================================
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 0-0 0 3 PPM 1-1 10 10 10 30 30 |
| PPM 10-0 PPM 0-3 PPM 3-3 PPM 10-3 PPM 0-10 PPM 10-|0
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.0% 90.0% 64.0% 76.0% 66.0% 34.0% 0.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 ----- P=0.219 P=1.000 P=0.354 P<0.001 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 570.0 606.8 602.0 650.0 632.1 645.0 560.0 481.6 |
|NATURAL DEATHS (C) | (27.6) (50.3) (27.8) (13.1) (29.7) (12.2) (10.6) (10.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 694.0 716.8 683.3 710.0 696.0 673.6 560.0 481.6 |
|(STANDARD ERROR) | (11.1) ( 6.9) (13.1) ( 5.7) (11.9) ( 9.8) (10.6) (10.8) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM 0-0 = 1
0 PPM 10-0 = 2
3 PPM 1-1 = 3
10 PPM 0-3 = 4
10 PPM 3-3 = 5
10 PPM 10-3 = 6
30 PPM 0-10 = 7
30 PPM 10-10 = 8
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 5 6 4 5 2 1 3 8 8 6 7 7 1 2 4
| 5 3 88 6 56 1 7735 2 42 1 6 44 2 3
P | 888 7757 111664 24 325225 3 3
E | 8 8 7 7 7 1 16 6 4 225 2 4 3 3
R 80 + 8 8 8 77 7 1 66 1 11 22 54 45
C | 8 88 1 6121 2454
E | 8 888 7 7 7 6 1121224
N | 8 8 777 6 61122
T 60 + 88 7 77 6161
| 88 77
S | 88 8 77 77
U | 88 77
R 40 + 77
V | 8 88
I | 8 88 77 7
V |
A 20 + 88 8 8 7 7
L | 88 777
| 88 77
| 88 77
0 + 8 7
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 96 obs hidden.
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM 0-0 = 1
0 PPM 10-0 = 2
3 PPM 1-1 = 3
10 PPM 0-3 = 4
10 PPM 3-3 = 5
10 PPM 10-3 = 6
30 PPM 0-10 = 7
30 PPM 10-10 = 8
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 5 8 3 3 77 16 1 2 6 4 5 4
| 8 38 7 7 1 7 32 63 616 5 5 24 2
P | 8 88 8 7 7 3 1616 1 3634 44 4 2 2 2
E | 8 8 77 7 1 133 515 44
R 80 + 88 636315 43 144 1 1
C | 8 8 77 6 6 33 54 4
E | 8 8 8 7 7 66 33 5355
N | 888 77 6 66 3 3 3
T 60 + 88 77 666
| 888 77
S | 88 7 777 666
U | 88 6 6
R 40 + 7 7 66
V | 8 8 6 6
I | 777 7
V | 8 8
A 20 + 7 7
L | 8 8 77
| 8 8 8 7 7 77
| 8 8 8 777
0 + 8 7
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 70 obs hidden.
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