National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2449

TDMS Study 05077-02 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/10/94   
EXP: 05077         FIREMASTER FF-1 POLYBROMINATED BIPHENYL     TIME: 09:43:18   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 53634B   
CONT: NO1-ES-82151                                             CAS: 67774327    
PATHOLOGIST: M. RYAN                         S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/10/94  
EXP: 05077         FIREMASTER FF-1 POLYBROMINATED BIPHENYL     TIME: 09:43:18  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 53634B  
CONT: NO1-ES-82151                                             CAS: 67774327   
PATHOLOGIST: M. RYAN                         S. EUSTIS                         

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 727 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM   0-0                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 0    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      268   447   531   531   531   535   541   545   554   632                 |
 |      648   658   667   683   691   704   705   707   714                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0 PPM   10-0                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      244   485   516   581   607   617   624   632   652   655                 |
 |      665   670   678   695   698   711   719   721                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 3 PPM   1-1                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 49     UNCENSORED DEATHS 7      CENSORED DEATHS 0    TERMINAL 42        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      79    307   468   597   605   662   712                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 727 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 10 PPM   0-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      160   505   560   561   587   604   604   607   667   687                 |
 |      702   706   716   720   723   723                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 10 PPM   3-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      122   183   415   475   575   611   631   640   653   684                 |
 |      692   708   709   716   719   720                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 10 PPM   10-3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      138   391   421   541   548   559   559   562   591   598                 |
 |      651   653   662   670   671   672   684   694   702   716                 |
 |      725                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 727 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 30 PPM   0-10                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 50     CENSORED DEATHS 0    TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      404   420   450   461   464   475   477   496   510   513                 |
 |      530   531   531   531   540   573   573   580   582   587                 |
 |      591   599   609   609   613   625   636   636   641   641                 |
 |      642   648   649   650   654   655   659   662   664   665                 |
 |      676   679   682   688   694   699   700   703   704   706                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 30 PPM   10-10                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 50     CENSORED DEATHS 0    TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      314   342   345   349   353   363   363   372   373   374                 |
 |      384   400   440   445   461   468   470   493   494   496                 |
 |      498   500   501   508   512   513   519   524   526   531                 |
 |      531   531   545   548   565   572   572   572   574   580                 |
 |      608   622   623   625   627   631   635   636   639   639                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 727 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   727 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM   0-0|   100.0 100.0  98.0  98.0  98.0  96.0  84.0  82.0  76.0  62.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0          |   100.0 100.0  98.0  98.0  98.0  96.0  94.0  92.0  78.0  64.0      |
 |PPM   10-0 |                                                                    |
 |           |                                                                    |
 |3 PPM   1-1|    98.0  98.0  98.0  95.9  95.9  93.9  93.9  89.8  87.8  85.7      |
 |           |                                                                    |
 |           |                                                                    |
 |10         |   100.0  98.0  98.0  98.0  98.0  98.0  96.0  86.0  84.0  68.0      |
 |PPM   0-3  |                                                                    |
 |           |                                                                    |
 |10         |   100.0  98.0  96.0  96.0  94.0  92.0  92.0  90.0  82.0  68.0      |
 |PPM   3-3  |                                                                    |
 |           |                                                                    |
 |10         |   100.0  98.0  98.0  98.0  94.0  94.0  92.0  80.0  74.0  58.0      |
 |PPM   10-3 |                                                                    |
 |           |                                                                    |
 |30         |   100.0 100.0 100.0 100.0  96.0  86.0  70.0  56.0  20.0   0.0      |
 |PPM   0-10 |                                                                    |
 |           |                                                                    |
 |30         |   100.0 100.0 100.0  86.0  76.0  66.0  34.0  20.0   0.0   0.0      |
 |PPM   10-10|                                                                    |
 |           |                                                                    |
 ==================================================================================

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 727 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0 PPM   0-0 0           3 PPM   1-1 10          10          10          30          30       |
 |                                            PPM   10-0              PPM   0-3   PPM   3-3   PPM   10-3  PPM   0-10  PPM   10-|0
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       62.0%       64.0%       85.7%       68.0%       68.0%       58.0%        0.0%        0.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P<0.001      -----      P=0.017N    P=0.538N    P=0.585N    P=0.853     P<0.001     P<0.001  |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       594.3       620.6       490.0       614.5       578.3       590.9       598.1       502.1    |
 |NATURAL DEATHS (C)      |       (26.1)      (27.0)      (85.4)      (35.0)      (47.1)      (30.0)      (11.8)      (13.6)   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       676.6       688.7       693.1       691.0       679.4       669.8       598.1       502.1    |
 |(STANDARD ERROR)        |       (13.4)      (12.0)      (16.5)      (13.3)      (17.8)      (15.7)      (11.8)      (13.6)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM   0-0                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 11     CENSORED DEATHS 0    TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      428   451   533   533   533   548   575   612   647   687                 |
 |      723                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0 PPM   10-0                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 5      CENSORED DEATHS 0    TERMINAL 45        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      491   492   620   708   723                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 3 PPM   1-1                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      309   341   490   512   603   603   621   621   624   627                 |
 |      640   673   677   680   687   692   710   726                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 10 PPM   0-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 0    TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      540   617   629   630   640   650   661   662   666   694                 |
 |      704   707                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 10 PPM   3-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      194   563   575   621   624   624   638   653   654   667                 |
 |      692   694   699   701   703   718   725                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 10 PPM   10-3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 33     CENSORED DEATHS 0    TERMINAL 17        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      435   509   531   546   554   555   610   611   617   617                 |
 |      627   636   645   648   651   651   656   667   676   680                 |
 |      684   688   692   692   697   703   703   706   715   717                 |
 |      717   725   725                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 30 PPM   0-10                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 50     CENSORED DEATHS 0    TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      359   365   440   470   484   484   485   491   505   505                 |
 |      506   508   513   515   515   519   519   529   530   532                 |
 |      533   533   533   544   561   573   575   575   576   580                 |
 |      589   592   595   595   599   606   617   620   622   633                 |
 |      634   635   636   641   652   660   671   678   683   683                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 30 PPM   10-10                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 50     CENSORED DEATHS 0    TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      291   312   347   350   364   369   389   389   401   402                 |
 |      403   411   442   445   454   463   463   470   477   480                 |
 |      484   489   495   498   501   502   506   512   512   512                 |
 |      515   515   515   519   519   519   520   533   533   533                 |
 |      533   537   538   554   557   571   592   606   619   620                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM   0-0|   100.0 100.0 100.0 100.0 100.0  96.0  90.0  86.0  82.0  78.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0          |   100.0 100.0 100.0 100.0 100.0 100.0  96.0  96.0  94.0  90.0      |
 |PPM   10-0 |                                                                    |
 |           |                                                                    |
 |3 PPM   1-1|   100.0 100.0 100.0  96.0  96.0  96.0  92.0  88.0  78.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 |10         |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  98.0  84.0  76.0      |
 |PPM   0-3  |                                                                    |
 |           |                                                                    |
 |10         |   100.0 100.0  98.0  98.0  98.0  98.0  98.0  94.0  82.0  66.0      |
 |PPM   3-3  |                                                                    |
 |           |                                                                    |
 |10         |   100.0 100.0 100.0 100.0 100.0  98.0  94.0  88.0  66.0  34.0      |
 |PPM   10-3 |                                                                    |
 |           |                                                                    |
 |30         |   100.0 100.0 100.0  96.0  96.0  86.0  52.0  30.0   8.0   0.0      |
 |PPM   0-10 |                                                                    |
 |           |                                                                    |
 |30         |   100.0 100.0 100.0  90.0  76.0  58.0  14.0   6.0   0.0   0.0      |
 |PPM   10-10|                                                                    |
 |           |                                                                    |
 ==================================================================================

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0 PPM   0-0 0           3 PPM   1-1 10          10          10          30          30       |
 |                                            PPM   10-0              PPM   0-3   PPM   3-3   PPM   10-3  PPM   0-10  PPM   10-|0
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       78.0%       90.0%       64.0%       76.0%       66.0%       34.0%        0.0%        0.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P<0.001      -----      P=0.219     P=1.000     P=0.354     P<0.001     P<0.001     P<0.001  |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       570.0       606.8       602.0       650.0       632.1       645.0       560.0       481.6    |
 |NATURAL DEATHS (C)      |       (27.6)      (50.3)      (27.8)      (13.1)      (29.7)      (12.2)      (10.6)      (10.8)   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       694.0       716.8       683.3       710.0       696.0       673.6       560.0       481.6    |
 |(STANDARD ERROR)        |       (11.1)      ( 6.9)      (13.1)      ( 5.7)      (11.9)      ( 9.8)      (10.6)      (10.8)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM   0-0      = 1
                                                        0 PPM   10-0     = 2
                                                        3 PPM   1-1      = 3
                                                        10 PPM   0-3     = 4
                                                        10 PPM   3-3     = 5
                                                        10 PPM   10-3    = 6
                                                        30 PPM   0-10    = 7
                                                        30 PPM   10-10   = 8

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1            3      5 6  4    5        2   1    3 8   8       6 7 7   1      2  4
      |                               5                 3     88      6   56  1 7735 2  42  1 6 44 2   3
P     |                                                        888               7757       111664 24  325225    3      3
E     |                                                          8 8                7 7 7     1 16    6 4  225 2  4     3 3
R  80 +                                                            8 8  8               77  7   1     66    1 11 22 54 45
C     |                                                                 8    88                                1 6121 2454
E     |                                                                       8  888        7 7   7               6 1121224
N     |                                                                            8  8           777               6 61122
T  60 +                                                                               88            7 77               6161
      |                                                                                88              77
S     |                                                                                 88 8            77 77
U     |                                                                                    88               77
R  40 +                                                                                                      77
V     |                                                                                     8 88
I     |                                                                                        8 88           77 7
V     |
A  20 +                                                                                           88    8 8      7 7
L     |                                                                                                   88       777
      |                                                                                                    88        77
      |                                                                                                     88        77
    0 +                                                                                                      8         7
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 96 obs hidden.

                                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM   0-0      = 1
                                                        0 PPM   10-0     = 2
                                                        3 PPM   1-1      = 3
                                                        10 PPM   0-3     = 4
                                                        10 PPM   3-3     = 5
                                                        10 PPM   10-3    = 6
                                                        30 PPM   0-10    = 7
                                                        30 PPM   10-10   = 8

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                              5              8   3   3  77         16  1     2 6     4  5        4
      |                                                   8   38  7          7  1  7 32 63  616  5 5      24            2
P     |                                                        8 88   8            7 7   3   1616  1    3634 44  4      2 2 2
E     |                                                               8 8            77 7          1     133 515 44
R  80 +                                                                 88                                636315  43 144  1 1
C     |                                                                  8    8         77                  6 6    33 54    4
E     |                                                                       8 8 8      7 7                  66    33 5355
N     |                                                                           888      77                  6  66    3 3 3
T  60 +                                                                             88      77                     666
      |                                                                              888     77
S     |                                                                                88     7  777                 666
U     |                                                                                 88                             6 6
R  40 +                                                                                            7  7                  66
V     |                                                                                  8 8                              6 6
I     |                                                                                               777 7
V     |                                                                                    8 8
A  20 +                                                                                                   7 7
L     |                                                                                      8  8           77
      |                                                                                         8 8   8      7 7 77
      |                                                                                               8 8 8       777
    0 +                                                                                                   8         7
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 70 obs hidden.

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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.