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TDMS Study 05077-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL


NTP Experiment-Test: 05077-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: DOSED FEED                                                                                                 Time: 05:22:32




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  67774327

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10           10            9           12            8           10           
    Natural Death                                                   1            1            2            3            2           
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           39           39           36           39           38           
    Moribund Sacrifice                                                           1                                                  
  Animals Examined Microscopically                    50           50           50           50           50           50           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (10)         (11)         (13)         (10)         (12)         
      Leiomyosarcoma                                                                                       1 (10%)                  
   Intestine Small, Duodenum                          (50)         (12)         (11)         (13)         (10)         (12)         
      Schwannoma Malignant                                          1 (8%)                                                          
      Serosa, Adenocarcinoma, Metastatic, Uterus                    1 (8%)                                                          
   Liver                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Hepatocellular Carcinoma                                                                2 (4%)       1 (2%)       7 (14%)     
      Hepatocellular Carcinoma, Multiple                                                                                1 (2%)      
      Hepatocellular Adenoma                                                     2 (4%)       6 (12%)     12 (24%)     15 (30%)     
      Hepatocellular Adenoma, Multiple                                           1 (2%)       4 (8%)      10 (20%)     20 (40%)     
      Hepatocholangiocarcinoma                                                                             1 (2%)                   
   Mesentery                                          (2)          (1)          (1)          (1)          (1)          (4)          
      Hepatocellular Carcinoma, Metastatic, Liver                                                                       1 (25%)     
   Pancreas                                           (49)         (12)         (11)         (13)         (9)          (12)         
      Adenocarcinoma, Metastatic, Uterus                            1 (8%)                                                          
   Stomach                                            (50)         (49)         (50)         (50)         (50)         (50)         
      Serosa, Adenocarcinoma, Metastatic, Uterus                    1 (2%)                                                          
   Stomach, Forestomach                               (50)         (49)         (50)         (50)         (50)         (49)         
      Squamous Cell Carcinoma                                                                 1 (2%)                                
   Stomach, Glandular                                 (50)         (48)         (50)         (50)         (50)         (50)         
      Sarcoma                                                                                 1 (2%)                                
   Tongue                                                          (1)          (1)          (1)          (1)          (1)          
      Carcinoma, Metastatic, Zymbal's Gland                                                                             1 (100%)    
      Squamous Cell Carcinoma                                                                 1 (100%)     1 (100%)                 
      Squamous Cell Papilloma                                       1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (11)         (12)         (14)         (11)         (12)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (11)         (12)         (14)         (9)          (12)         
      Capsule, Adenocarcinoma, Metastatic, Uterus                   1 (9%)                                                          
   Adrenal Gland, Cortex                              (50)         (10)         (12)         (14)         (9)          (12)         
      Adenoma                                          1 (2%)       1 (10%)                                                         
   Adrenal Gland, Medulla                             (48)         (10)         (12)         (13)         (9)          (12)         
      Pheochromocytoma Malignant                                                 1 (8%)                                             
      Pheochromocytoma Benign                          2 (4%)                    1 (8%)                                             
      Bilateral, Pheochromocytoma Benign               1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (12)         (11)         (13)         (9)          (12)         
      Carcinoma                                                     1 (8%)                                                          
   Parathyroid Gland                                  (46)         (9)          (11)         (14)         (9)          (10)         
      Adenoma                                          2 (4%)                                                                       
   Pituitary Gland                                    (50)         (34)         (27)         (29)         (28)         (27)         
      Pars Distalis, Adenoma                          21 (42%)     19 (56%)     19 (70%)     18 (62%)     12 (43%)     12 (44%)     
      Pars Intermedia, Adenoma                                                                2 (7%)       1 (4%)                   
   Thyroid Gland                                      (50)         (12)         (15)         (14)         (10)         (13)         
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                 10 (20%)      4 (33%)      4 (27%)      3 (21%)                   2 (15%)     
      C-Cell, Adenoma, Moderate                                     1 (8%)                                                          
      C-Cell, Carcinoma                                             1 (8%)       2 (13%)      1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                                          (1)          
      Liposarcoma                                                                                                       1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (15)         (12)         (16)         (10)         (13)         
      Adenoma                                          3 (6%)       1 (7%)                    1 (6%)                    1 (8%)      
      Bilateral, Adenoma                                            1 (7%)                                                          
   Ovary                                              (50)         (23)         (19)         (22)         (14)         (20)         
      Granulosa-Theca Tumor Malignant                                            1 (5%)                                             
      Periovarian Tissue, Adenocarcinoma,                                                                                           
          Metastatic, Uterus                                        1 (4%)                                                          
      Periovarian Tissue, Leiomyoma                                                           1 (5%)                                
   Uterus                                             (50)         (17)         (18)         (18)         (21)         (20)         
      Adenocarcinoma                                   2 (4%)       1 (6%)       2 (11%)                                            
      Polyp Stromal                                    7 (14%)      4 (24%)      2 (11%)      3 (17%)      6 (29%)      4 (20%)     
                                                             Page   3                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Sarcoma Stromal                                                                         1 (6%)                                
      Schwannoma Malignant                             1 (2%)                                                                       
      Epithelium, Adenoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (11)         (11)         (13)         (9)          (11)         
   Lymph Node                                         (50)         (11)         (11)         (14)         (12)         (12)         
      Mediastinal, Adenocarcinoma, Metastatic,                                                                                      
           Uterus                                                   1 (9%)                                                          
   Lymph Node, Mesenteric                             (4)          (2)          (3)          (1)          (1)          (3)          
      Adenocarcinoma, Metastatic, Uterus                            1 (50%)                                                         
   Spleen                                             (50)         (50)         (50)         (50)         (49)         (49)         
   Thymus                                             (44)         (9)          (11)         (11)         (9)          (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (16)         (13)         (21)         (16)         (11)         
      Adenoma                                                                                              1 (6%)                   
      Carcinoma                                                     1 (6%)                                                          
      Fibroadenoma                                     4 (8%)       7 (44%)      2 (15%)     10 (48%)      7 (44%)      2 (18%)     
      Fibroadenoma, Multiple                                                     1 (8%)       1 (5%)                                
   Skin                                               (50)         (11)         (12)         (13)         (11)         (14)         
      Basal Cell Adenoma                               1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Trichoepithelioma                                1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                                  1 (9%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                                          1 (8%)                                 3 (21%)     
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (11)         (11)         (14)         (10)         (12)         
      Astrocytoma Malignant                            2 (4%)                                 1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (11)         (11)         (14)         (9)          (11)         
      Adenocarcinoma, Metastatic, Uterus                            1 (9%)       1 (9%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                                                                       1 (9%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                                            (1)                       (1)          
      Carcinoma                                                                               1 (100%)                  1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (11)         (11)         (14)         (11)         (12)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)        *(50)        *(50)         
      Leukemia Mononuclear                            14 (28%)     13 (26%)     20 (40%)     22 (44%)     17 (34%)     27 (54%)     
      Lymphoma Malignant Lymphocytic                                             1 (2%)                                             
      Mesothelioma Malignant                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          37          35          42          41          49               
     Total Primary Neoplasms                           77          58          61          80          70          96               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 34          30          25          33          34          41               
     Total Benign Neoplasms                            56          40          33          49          49          56               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          16          25          28          20          31               
     Total Malignant Neoplasms                         21          18          28          31          21          40               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1           1                                   2               
     Total Metastatic Neoplasm                                      8           1                                   3               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Natural Death                                      5            2                                                               
    Moribund Sacrifice                                10           15                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           32                                                               
    Natural Death                                      1            1                                                               
  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (50)         (50)                                                             
      Hepatocellular Carcinoma                         4 (8%)      16 (32%)                                                         
      Hepatocellular Carcinoma, Multiple                            6 (12%)                                                         
      Hepatocellular Adenoma                           1 (2%)       1 (2%)                                                          
      Hepatocellular Adenoma, Multiple                37 (74%)     44 (88%)                                                         
      Hepatocholangiocarcinoma                         1 (2%)                                                                       
   Pancreas                                           (50)         (50)                                                             
   Stomach, Forestomach                               (48)         (50)                                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)                                                             
      Adenoma                                                       1 (2%)                                                          
      Bilateral, Adenoma                               1 (2%)                                                                       
   Adrenal Gland, Medulla                             (49)         (49)                                                             
   Pituitary Gland                                    (50)         (50)                                                             
      Pars Distalis, Adenoma                           2 (4%)       5 (10%)                                                         
      Pars Distalis, Adenoma, Mild                     1 (2%)                                                                       
      Pars Distalis, Adenoma, Moderate                 1 (2%)                                                                       
   Thyroid Gland                                      (48)         (48)                                                             
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      C-Cell, Adenoma                                  2 (4%)       7 (15%)                                                         
      C-Cell, Carcinoma                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (46)                                                             
      Carcinoma                                        1 (2%)       1 (2%)                                                          
   Ovary                                              (48)         (49)                                                             
      Leiomyosarcoma                                   1 (2%)                                                                       
   Uterus                                             (49)         (50)                                                             
      Adenocarcinoma                                                1 (2%)                                                          
      Leiomyosarcoma                                                1 (2%)                                                          
      Polyp Stromal                                    7 (14%)      4 (8%)                                                          
      Sarcoma Stromal                                               1 (2%)                                                          
   Vagina                                                          (2)                                                              
      Leiomyosarcoma                                                1 (50%)                                                         
      Polyp                                                         1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (47)                                                             
   Lymph Node                                         (49)         (47)                                                             
   Lymph Node, Mesenteric                             (5)                                                                           
   Spleen                                             (50)         (50)                                                             
   Thymus                                             (41)         (42)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (48)                                                             
      Adenoma                                                       1 (2%)                                                          
      Fibroadenoma                                     1 (2%)       4 (8%)                                                          
      Fibroadenoma, Multiple                           1 (2%)                                                                       
   Skin                                               (49)         (50)                                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                      1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (47)         (50)                                                             
      Alveolar/Bronchiolar Adenoma                     2 (4%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Squamous Cell Carcinoma, Multiple,                                                                                            
          Metastatic, Uncertain Primary Site                        1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Clitoral Gland                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Transitional Epithelium, Carcinoma                            1 (2%)                                                          
   Urinary Bladder                                    (49)         (50)                                                             
      Papilloma                                                     1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)                                                             
      Leukemia Mononuclear                            23 (46%)     25 (50%)                                                         
      Lymphoma Malignant Histiocytic                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          50                                                               
     Total Primary Neoplasms                           90         125                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41          46                                                               
     Total Benign Neoplasms                            59          71                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              27          36                                                               
     Total Malignant Neoplasms                         31          54                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1                                                               
     Total Metastatic Neoplasm                          2           1                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Natural Death                                      5            4            1            6            5            4           
    Moribund Sacrifice                                16           16           15           21           25           26           
  Survivors                                                                                                                         
    Natural Death                                                   1                                                               
    Terminal Sacrifice                                29           29           34           22           19           19           
    Moribund Sacrifice                                                                        1            1            1           
  Animals Examined Microscopically                    50           50           50           50           50           50           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (20)         (16)         (26)         (30)         (29)         
   Intestine Large, Colon                             (49)         (21)         (16)         (27)         (31)         (30)         
   Intestine Large, Rectum                            (49)         (21)         (16)         (27)         (30)         (30)         
   Intestine Small, Duodenum                          (48)         (21)         (16)         (27)         (31)         (30)         
   Intestine Small, Ileum                             (49)         (19)         (16)         (28)         (29)         (29)         
      Adenocarcinoma                                   1 (2%)                                 1 (4%)                                
   Intestine Small, Jejunum                           (49)         (20)         (16)         (27)         (30)         (30)         
      Adenocarcinoma                                                                          1 (4%)                                
   Liver                                              (50)         (50)         (50)         (49)         (50)         (50)         
      Adenocarcinoma, Metastatic, Prostate                          1 (2%)                                                          
      Adenocarcinoma, Metastatic, Intestine Small                                             1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Hepatocellular Carcinoma                                                   1 (2%)       2 (4%)       1 (2%)       1 (2%)      
      Hepatocellular Adenoma                           1 (2%)       4 (8%)       3 (6%)       4 (8%)       6 (12%)     10 (20%)     
      Hepatocellular Adenoma, Multiple                              1 (2%)       2 (4%)       6 (12%)      7 (14%)      6 (12%)     
   Mesentery                                                       (6)                       (3)          (1)          (2)          
      Adenocarcinoma, Metastatic, Prostate                          1 (17%)                                                         
      Lipoma                                                                                                            1 (50%)     
   Pancreas                                           (49)         (21)         (16)         (27)         (32)         (31)         
      Acinus, Adenoma                                  1 (2%)                    1 (6%)       1 (4%)       3 (9%)       1 (3%)      
   Salivary Glands                                    (50)         (21)         (16)         (27)         (30)         (30)         
      Schwannoma Malignant                             1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (49)         (48)         (49)         (50)         (50)         
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                                       1 (2%)                    1 (2%)                                
   Stomach, Glandular                                 (50)         (48)         (48)         (48)         (50)         (49)         
      Carcinoid Tumor Malignant                                     1 (2%)                                                          
   Tongue                                                                                                 (1)                       
      Squamous Cell Carcinoma                                                                              1 (100%)                 
   Tooth                                                                                     (1)                                    
      Gingiva, Squamous Cell Carcinoma                                                        1 (100%)                              
                                                             Page  11                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (21)         (16)         (27)         (31)         (31)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (21)         (15)         (28)         (31)         (30)         
   Adrenal Gland, Medulla                             (49)         (22)         (16)         (29)         (32)         (30)         
      Pheochromocytoma Malignant                       1 (2%)                                 1 (3%)       1 (3%)       1 (3%)      
      Pheochromocytoma Complex                                      1 (5%)       1 (6%)                                             
      Pheochromocytoma Benign                         11 (22%)      4 (18%)      1 (6%)       1 (3%)       2 (6%)       3 (10%)     
      Bilateral, Pheochromocytoma Benign               1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (21)         (16)         (27)         (31)         (30)         
      Adenoma                                          4 (8%)       1 (5%)                    1 (4%)       1 (3%)                   
      Carcinoma                                        3 (6%)                                                                       
   Parathyroid Gland                                  (43)         (21)         (16)         (27)         (31)         (29)         
      Adenoma                                                                                 1 (4%)                    2 (7%)      
   Pituitary Gland                                    (50)         (27)         (22)         (32)         (30)         (34)         
      Pars Distalis, Adenoma                          13 (26%)      7 (26%)      9 (41%)     11 (34%)      9 (30%)     11 (32%)     
      Pars Distalis, Adenoma, Multiple                                                        1 (3%)                                
      Pars Nervosa, Astrocytoma Malignant,                                                                                          
          Metastatic, Brain                                         1 (4%)                                                          
   Thyroid Gland                                      (49)         (23)         (17)         (28)         (31)         (30)         
      Bilateral, C-Cell, Adenoma                       1 (2%)       1 (4%)                    1 (4%)                                
      Bilateral, Follicular Cell, Adenoma                                                                               1 (3%)      
      C-Cell, Adenoma                                 16 (33%)      3 (13%)      4 (24%)      8 (29%)      3 (10%)      8 (27%)     
      C-Cell, Carcinoma                                1 (2%)       2 (9%)       1 (6%)                    3 (10%)                  
      Follicular Cell, Adenoma                         1 (2%)                                 1 (4%)       2 (6%)                   
      Follicular Cell, Carcinoma                                    2 (9%)                    1 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Chordoma                                                      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (20)         (16)         (28)         (30)         (30)         
      Adenocarcinoma, Metastatic, Prostate                          1 (5%)                                                          
   Preputial Gland                                    (47)         (25)         (20)         (32)         (34)         (32)         
      Adenoma                                          4 (9%)       1 (4%)       1 (5%)                    1 (3%)                   
      Carcinoma                                        3 (6%)       3 (12%)      3 (15%)      4 (13%)      4 (12%)      2 (6%)      
      Duct, Squamous Cell Papilloma                    1 (2%)                                                                       
                                                             Page  12                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
   Prostate                                           (50)         (21)         (16)         (28)         (30)         (31)         
      Adenocarcinoma                                                1 (5%)                                                          
   Testes                                             (50)         (49)         (50)         (50)         (50)         (50)         
      Bilateral, Interstitial Cell, Adenoma           43 (86%)     41 (84%)     43 (86%)     45 (90%)     37 (74%)     42 (84%)     
      Interstitial Cell, Adenoma                       6 (12%)      5 (10%)      4 (8%)       4 (8%)       9 (18%)      5 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (21)         (15)         (27)         (31)         (30)         
   Lymph Node                                         (50)         (23)         (18)         (27)         (33)         (31)         
      Mediastinal, Adenocarcinoma, Metastatic,                                                                                      
           Prostate                                                 1 (4%)                                                          
      Mediastinal, Fibrosarcoma, Metastatic, Skin                                                          1 (3%)                   
   Lymph Node, Mesenteric                             (2)          (3)          (2)          (9)          (8)          (4)          
      Adenocarcinoma, Metastatic, Prostate                          1 (33%)                                                         
      Fibrosarcoma, Metastatic, Skin                   1 (50%)                                                                      
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (50%)                                                                      
   Spleen                                             (50)         (50)         (49)         (49)         (50)         (50)         
      Fibrosarcoma                                                               1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
   Thymus                                             (47)         (17)         (15)         (22)         (24)         (27)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (39)         (14)         (14)         (23)         (20)         (18)         
      Fibroadenoma                                     1 (3%)                    2 (14%)      4 (17%)                               
   Skin                                               (50)         (26)         (22)         (31)         (32)         (32)         
      Basosquamous Tumor Benign                                                                                         1 (3%)      
      Fibroma                                                                                 1 (3%)                                
      Keratoacanthoma                                  2 (4%)                    1 (5%)                                             
      Squamous Cell Papilloma                          1 (2%)                                              1 (3%)                   
      Trichoepithelioma                                                                       1 (3%)       1 (3%)                   
      Sebaceous Gland, Adenoma                                                   1 (5%)                                             
      Subcutaneous Tissue, Fibroma                     5 (10%)      2 (8%)       6 (27%)      1 (3%)       4 (13%)      2 (6%)      
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)       4 (15%)      3 (14%)      2 (6%)       1 (3%)       1 (3%)      
      Subcutaneous Tissue, Neurofibrosarcoma                                                  1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  13                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (21)         (16)         (28)         (31)         (31)         
      Femur, Hemangiosarcoma                                                                                            1 (3%)      
      Femur, Osteosarcoma                                                        1 (6%)                                             
      Lumbar, Osteosarcoma                                                                                              1 (3%)      
      Rib, Osteosarcoma                                             1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (21)         (16)         (29)         (31)         (31)         
      Astrocytoma Malignant                                         1 (5%)                                                          
      Glioma Malignant                                                                                     1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (21)         (17)         (28)         (32)         (31)         
      Adenocarcinoma, Metastatic, Prostate                          1 (5%)                                                          
      Alveolar/Bronchiolar Adenoma                     2 (4%)                    2 (12%)      1 (4%)                    1 (3%)      
      Alveolar/Bronchiolar Carcinoma                                             1 (6%)       1 (4%)       1 (3%)                   
      Carcinoma Adenosquamous                                                                              1 (3%)       1 (3%)      
      Chordoma, Metastatic, Uncertain Primary Site                               1 (6%)                                             
      Fibrosarcoma, Metastatic, Skin                                             1 (6%)                    1 (3%)                   
      Osteosarcoma, Metastatic, Bone                                             1 (6%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
      Pheochromocytoma Complex, Metastatic,                                                                                         
          Adrenal Gland                                                          1 (6%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (6%)                                             
   Nose                                               (50)         (21)         (16)         (27)         (31)         (30)         
      Submucosa, Glands, Adenocarcinoma                             2 (10%)                                                         
   Trachea                                            (50)         (21)         (16)         (27)         (31)         (31)         
      Peritracheal Tissue, Fibrosarcoma,                                                                                            
          Metastatic, Skin                                                                                 1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  14                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (24)         (20)         (32)         (32)         (37)         
      Medulla, Sarcoma                                 1 (2%)                                                                       
      Renal Tubule, Adenoma                                         1 (4%)                                 2 (6%)                   
      Renal Tubule, Carcinoma                          1 (2%)                                                                       
   Urinary Bladder                                    (49)         (20)         (17)         (27)         (31)         (30)         
      Adenocarcinoma, Metastatic, Prostate                          1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)        *(50)        *(50)         
      Leukemia Mononuclear                            25 (50%)     32 (64%)     32 (64%)     33 (66%)     41 (82%)     37 (74%)     
      Lymphoma Malignant Histiocytic                                1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                                1 (2%)                                              1 (2%)      
      Mesothelioma Benign                              1 (2%)                                                           1 (2%)      
      Mesothelioma Malignant                           1 (2%)       5 (10%)                   2 (4%)       1 (2%)       3 (6%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  15                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          50          50          50          50               
     Total Primary Neoplasms                          157         130         124         145         144         144               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 50          47          48          50          47          48               
     Total Benign Neoplasms                           116          72          80          94          88          95               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              34          42          39          41          43          41               
     Total Malignant Neoplasms                         41          58          44          51          56          49               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           3           5           1           1                           
     Total Metastatic Neoplasm                          4           9           6           1           3                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  16                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23           24                                                               
    Natural Death                                      3            7                                                               
  Survivors                                                                                                                         
    Moribund Sacrifice                                 1            1                                                               
    Terminal Sacrifice                                23           18                                                               
  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (48)         (48)                                                             
      Leiomyoma                                                     2 (4%)                                                          
      Leiomyosarcoma                                   1 (2%)                                                                       
      Leiomyosarcoma, Metastatic, Mesentery            1 (2%)                                                                       
   Liver                                              (50)         (50)                                                             
      Hepatocellular Carcinoma                        12 (24%)     13 (26%)                                                         
      Hepatocellular Carcinoma, Multiple               7 (14%)     10 (20%)                                                         
      Hepatocellular Adenoma                           2 (4%)       3 (6%)                                                          
      Hepatocellular Adenoma, Multiple                36 (72%)     35 (70%)                                                         
      Squamous Cell Carcinoma, Metastatic, Stomach     1 (2%)                                                                       
   Mesentery                                          (5)          (2)                                                              
      Fibrosarcoma                                     1 (20%)                                                                      
      Hemangiosarcoma                                               1 (50%)                                                         
      Squamous Cell Carcinoma, Metastatic, Stomach     1 (20%)                                                                      
   Pancreas                                           (49)         (50)                                                             
      Squamous Cell Carcinoma, Metastatic, Stomach     1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)                                                             
      Squamous Cell Carcinoma                          1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)                                                             
      Schwannoma Malignant                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)                                                             
      Adenoma                                                       1 (2%)                                                          
   Adrenal Gland, Medulla                             (50)         (50)                                                             
      Pheochromocytoma Benign                          2 (4%)       3 (6%)                                                          
                                                             Page  17                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Islets, Pancreatic                                 (49)         (50)                                                             
      Adenoma                                          2 (4%)       1 (2%)                                                          
   Parathyroid Gland                                  (49)         (47)                                                             
      Adenoma                                                       2 (4%)                                                          
   Pituitary Gland                                    (48)         (49)                                                             
      Pars Distalis, Adenoma                           4 (8%)       9 (18%)                                                         
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (49)         (49)                                                             
      C-Cell, Adenoma                                  8 (16%)     11 (22%)                                                         
      C-Cell, Adenoma, Multiple                        1 (2%)                                                                       
      C-Cell, Carcinoma                                1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)                                                             
   Preputial Gland                                    (44)         (49)                                                             
      Adenoma                                          1 (2%)       1 (2%)                                                          
      Carcinoma                                                     5 (10%)                                                         
   Testes                                             (50)         (50)                                                             
      Bilateral, Interstitial Cell, Adenoma           37 (74%)     36 (72%)                                                         
      Interstitial Cell, Adenoma                       9 (18%)     10 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)                                                             
   Lymph Node                                         (49)         (49)                                                             
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                1 (2%)                                                                       
   Lymph Node, Mesenteric                             (4)          (2)                                                              
   Spleen                                             (50)         (50)                                                             
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Thymus                                             (40)         (28)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)                                                             
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)       2 (4%)                                                          
      Subcutaneous Tissue, Fibroma                     2 (4%)       3 (6%)                                                          
                                                             Page  18                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Fibroma, Multiple           2 (4%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)                                                                       
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
      Subcutaneous Tissue, Neurofibroma                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)                                                             
      Femur, Osteosarcoma                                           1 (2%)                                                          
   Skeletal Muscle                                                 (1)                                                              
      Rhabdomyosarcoma                                              1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
      Oligodendroglioma Malignant                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)                                                             
      Alveolar/Bronchiolar Adenoma                     3 (6%)       1 (2%)                                                          
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                   3 (6%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Renal Tubule, Adenoma                                         1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)                                                             
      Leukemia Mononuclear                            31 (62%)     37 (74%)                                                         
      Mesothelioma Malignant                           1 (2%)                                                                       
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  19                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)                                                             
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                                                             Page  20                                                               
NTP Experiment-Test: 05077-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50                                                               
     Total Primary Neoplasms                          171         196                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          49                                                               
     Total Benign Neoplasms                           113         123                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              42          47                                                               
     Total Malignant Neoplasms                         58          73                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           4                                                               
     Total Metastatic Neoplasm                          6           4                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  21                                                               
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