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TDMS Study 05077-01 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                           FIREMASTER FF-1 POLYBROMINATED BIPHENYL                       DATE: 09/10/94       
EXPERIMENT: 05077 TEST: 01                                                                                     TIME: 05:41:47       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-82151          ROUTE: DOSED FEED                                                                  NTP C#: 53634B       
PATHOLOGIST: R. PERSING                      S. EUSTIS                                                         CAS: 67774327        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Battelle Columbus                           FIREMASTER FF-1 POLYBROMINATED BIPHENYL                       DATE: 09/10/94      
EXPERIMENT: 05077 TEST: 01                                                                                     TIME: 05:41:47      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: NO1-ES-82151          ROUTE: DOSED FEED                                                                  NTP C#: 53634B      
PATHOLOGIST: R. PERSING                      S. EUSTIS                                                         CAS: 67774327       
 
 
 
 
 
                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                           FIREMASTER FF-1 POLYBROMINATED BIPHENYL                       DATE: 09/10/94       
EXPERIMENT: 05077 TEST: 01                                                                                     TIME: 05:41:47       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-82151          ROUTE: DOSED FEED                                                                  NTP C#: 53634B       
PATHOLOGIST: R. PERSING                      S. EUSTIS                                                         CAS: 67774327        
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                             IN THE ANALYSIS OF THE STUDY OF FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
              ====================================================================================================
 
                                                           MALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Adrenal Medulla               Pheochromocytoma Benign
                                                           Pheochromocytoma: Benign, Complex, Malignant, NOS
                             Clitoral/Preputial Gland      Carcinoma
                                                           Carcinoma or Adenoma
                             Intestine Small               Leiomyoma
                             Islets, Pancreatic            Carcinoma
                                                           Carcinoma or Adenoma
                             Liver                         Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma
                                                           Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             Lung                          Alveolar/Bronchiolar Adenoma
                                                           Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
                                                           Carcinoma
                             Pancreas                      Adenoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                             Skin                          Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
                             Skin: Subcutaneous Tissue     Fibrosarcoma
                                                           Neurofibrosarcoma, Fibrosarcoma, or Sarcoma
                             Stomach, Forestomach          Squamous Cell Carcinoma
                             Testes                        Adenoma
                             All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear,
                                                            or Undifferentiated
                                                           Mesothelioma Benign, Malignant, NOS
                                                           Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
 
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                           FIREMASTER FF-1 POLYBROMINATED BIPHENYL                       DATE: 09/10/94       
EXPERIMENT: 05077 TEST: 01                                                                                     TIME: 05:41:47       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-82151          ROUTE: DOSED FEED                                                                  NTP C#: 53634B       
PATHOLOGIST: R. PERSING                      S. EUSTIS                                                         CAS: 67774327        
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                             IN THE ANALYSIS OF THE STUDY OF FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
              ====================================================================================================
 
                                                           FEMALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Adrenal Medulla               Pheochromocytoma Benign
                                                           Pheochromocytoma Malignant
                                                           Pheochromocytoma: Benign, Complex, Malignant, NOS
                             Clitoral/Preputial Gland      Adenoma
                             Liver                         Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma
                                                           Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                             Skin: Subcutaneous Tissue     Lipoma
                             Thyroid Gland: C-Cell         Adenoma
                                                           Carcinoma or Adenoma
                             All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear,
                                                            or Undifferentiated
                                                           Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE   1
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/71 (0%)    0/15 (0%)    0/89 (0%)    1/100 (1%) |  2/60 (3%)    0/12 (0%)    0/35 (0%)    2/100 (2%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         1.6%      |   3.7%         0.0%         0.0%         2.9%      |
|TERMINAL (d)           |  0/31 (0%)    0/0          0/4 (0%)     0/43 (0%)  |  1/40 (3%)    0/2 (0%)     0/1 (0%)     2/68 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          679       |   707          ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.210        (e)          (e)        P=0.468    |  P=0.549N     P=0.582N     P=0.404N     P=0.558N   |
|INCIDENTAL TUMOR       |  P=0.244        (e)          (e)        P=0.530    |  P=0.503N     P=0.608N     P=0.399N     P=0.496N   |
|LOGISTIC REGRESSION    |  P=0.332        (e)          (e)        P=0.568    |  P=0.490N     P=0.706N     P=0.552N     P=0.485N   |
|COCHRAN-ARMITAGE       |  P=0.324                                           |  P=0.567N                                          |
|FISHER EXACT           |                 (e)          (e)        P=0.585    |               P=0.692N     P=0.396N     P=0.482N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 16/71 (23%)   1/16 (6%)    6/91 (7%)    5/100 (5%) |  3/58 (5%)    1/12 (8%)    0/34 (0%)    0/98 (0%)  |
|ADJUSTED (b)           |  32.3%         0.0%         5.6%        11.6%      |   7.9%         2.4%         0.0%         0.0%      |
|TERMINAL (d)           |  7/30 (23%)   0/0          0/5 (0%)     5/43 (12%) |  3/38 (8%)    0/2 (0%)     0/1 (0%)     0/66 (0%)  |
|FIRST INCIDENCE (DAYS) |   580          679          455          727 (T)   |   729 (T)      727          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.008N**   P=0.091N     P=0.084N     P=0.005N** |  P=0.023N*    P=0.494      P=0.944N     P=0.045N*  |
|INCIDENTAL TUMOR       |  P=0.002N**   P=0.163N     P=0.008N**   P=0.001N** |  P=0.019N*    P=0.475      P=0.944N     P=0.045N*  |
|LOGISTIC REGRESSION    |  P=0.002N**   P=0.217N     P=0.008N**   P<0.001N** |  P=0.016N*    P=0.384      P=0.944N     P=0.045N*  |
|COCHRAN-ARMITAGE       |  P=0.002N**                                        |  P=0.025N*                                         |
|FISHER EXACT           |               P=0.124N     P=0.003N**   P<0.001N** |               P=0.537      P=0.246N     P=0.050N*  |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE   2
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/71 (1%)    0/16 (0%)    3/91 (3%)    0/100 (0%) |  0/58 (0%)    1/12 (8%)    0/34 (0%)    0/98 (0%)  |
|ADJUSTED (b)           |   1.5%         0.0%        40.7%         0.0%      |   0.0%        50.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/30 (0%)    0/0          2/5 (40%)    0/43 (0%)  |  0/38 (0%)    1/2 (50%)    0/1 (0%)     0/66 (0%)  |
|FIRST INCIDENCE (DAYS) |   706          ---          689          ---       |   ---          729 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.276N     P=0.612N     P=0.093      P=0.556N   |  P=0.348N     P=0.019 *      (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.232N     P=0.690N     P=0.138      P=0.478N   |  P=0.348N     P=0.019 *      (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.210N     P=0.875N     P=0.136      P=0.434N   |  P=0.348N     P=0.019 *      (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.246N                                          |  P=0.400N                                          |
|FISHER EXACT           |               P=0.816N     P=0.409      P=0.415N   |               P=0.171        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 17/71 (24%)   2/16 (13%)   9/91 (10%)   5/100 (5%) |  3/58 (5%)    2/12 (17%)   0/34 (0%)    0/98 (0%)  |
|ADJUSTED (b)           |  33.1%         0.0%        44.0%        11.6%      |   7.9%        51.2%         0.0%         0.0%      |
|TERMINAL (d)           |  7/30 (23%)   0/0          2/5 (40%)    5/43 (12%) |  3/38 (8%)    1/2 (50%)    0/1 (0%)     0/66 (0%)  |
|FIRST INCIDENCE (DAYS) |   580          487          455          727 (T)   |   729 (T)      727          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.003N**   P=0.153N     P=0.283N     P=0.003N** |  P=0.011N*    P=0.065      P=0.944N     P=0.045N*  |
|INCIDENTAL TUMOR       |  P<0.001N**   P=0.261N     P=0.059N     P<0.001N** |  P=0.009N**   P=0.057      P=0.944N     P=0.045N*  |
|LOGISTIC REGRESSION    |  P<0.001N**   P=0.329N     P=0.041N*    P<0.001N** |  P=0.008N**   P=0.027 *    P=0.944N     P=0.045N*  |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |  P=0.014N*                                         |
|FISHER EXACT           |               P=0.261N     P=0.014N*    P<0.001N** |               P=0.201      P=0.246N     P=0.050N*  |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE   3
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Astrocytoma Malignant                                                                                                       |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/71 (1%)    0/16 (0%)    0/91 (0%)    0/100 (0%) |  2/61 (3%)    0/11 (0%)    1/36 (3%)    0/99 (0%)  |
|ADJUSTED (b)           |   1.1%         0.0%         0.0%         0.0%      |   3.6%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/30 (0%)    0/0          0/4 (0%)     0/43 (0%)  |  1/40 (3%)    0/1 (0%)     0/0          0/67 (0%)  |
|FIRST INCIDENCE (DAYS) |   580          ---          ---          ---       |   656          ---          502          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.445N     P=0.632N     P=0.429N     P=0.502N   |  P=0.158N     P=0.611N     P=0.674N     P=0.187N   |
|INCIDENTAL TUMOR       |  P=0.338N     P=0.739N     P=0.326N     P=0.362N   |  P=0.121N     P=0.631N     P=0.645N     P=0.138N   |
|LOGISTIC REGRESSION    |  P=0.392N     P=0.719N     P=0.397N     P=0.449N   |  P=0.124N     P=0.680N     P=0.598N     P=0.141N   |
|COCHRAN-ARMITAGE       |  P=0.366N                                          |  P=0.109N                                          |
|FISHER EXACT           |               P=0.816N     P=0.438N     P=0.415N   |               P=0.716N     P=0.691N     P=0.144N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/71 (1%)    0/16 (0%)    1/91 (1%)    1/100 (1%) |  2/61 (3%)    0/11 (0%)    1/36 (3%)    0/99 (0%)  |
|ADJUSTED (b)           |   1.1%         0.0%         1.0%         2.2%      |   3.6%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/30 (0%)    0/0          0/4 (0%)     0/43 (0%)  |  1/40 (3%)    0/1 (0%)     0/0          0/67 (0%)  |
|FIRST INCIDENCE (DAYS) |   580          ---          676          718       |   656          ---          502          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.556      P=0.632N     P=0.690N     P=0.732    |  P=0.158N     P=0.611N     P=0.674N     P=0.187N   |
|INCIDENTAL TUMOR       |  P=0.682      P=0.739N     P=0.582N     P=0.672N   |  P=0.121N     P=0.631N     P=0.645N     P=0.138N   |
|LOGISTIC REGRESSION    |  P=0.636N     P=0.719N     P=0.676N     P=0.684N   |  P=0.124N     P=0.680N     P=0.598N     P=0.141N   |
|COCHRAN-ARMITAGE       |  P=0.633N                                          |  P=0.109N                                          |
|FISHER EXACT           |               P=0.816N     P=0.686N     P=0.659N   |               P=0.716N     P=0.691N     P=0.144N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE   4
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/72 (7%)    1/20 (5%)    1/98 (1%)    2/93 (2%)  |  5/65 (8%)    0/12 (0%)    2/39 (5%)    0/93 (0%)  |
|ADJUSTED (b)           |  13.5%        25.0%         7.7%         2.9%      |  11.1%         0.0%        33.8%         0.0%      |
|TERMINAL (d)           |  4/33 (12%)   1/4 (25%)    1/13 (8%)    0/42 (0%)  |  5/45 (11%)   0/2 (0%)     1/3 (33%)    0/65 (0%)  |
|FIRST INCIDENCE (DAYS) |   710          727 (T)      727 (T)      631       |   729 (T)      ---          615          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.145N     P=0.692      P=0.343N     P=0.201N   |  P=0.010N*    P=0.747N     P=0.239      P=0.011N*  |
|INCIDENTAL TUMOR       |  P=0.114N     P=0.659      P=0.296N     P=0.141N   |  P=0.009N**   P=0.747N     P=0.281      P=0.011N*  |
|LOGISTIC REGRESSION    |  P=0.125N     P=0.685      P=0.295N     P=0.137N   |  P=0.011N*    P=0.747N     P=0.623      P=0.011N*  |
|COCHRAN-ARMITAGE       |  P=0.140N                                          |  P=0.014N*                                         |
|FISHER EXACT           |               P=0.612N     P=0.050N*    P=0.131N   |               P=0.418N     P=0.473N     P=0.011N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/72 (8%)    3/20 (15%)  10/98 (10%)   5/93 (5%)  |  0/65 (0%)    0/12 (0%)    0/39 (0%)    2/93 (2%)  |
|ADJUSTED (b)           |  16.6%        28.6%        34.8%         7.9%      |   0.0%         0.0%         0.0%         3.1%      |
|TERMINAL (d)           |  5/33 (15%)   1/4 (25%)    4/13 (31%)   1/42 (2%)  |  0/45 (0%)    0/2 (0%)     0/3 (0%)     2/65 (3%)  |
|FIRST INCIDENCE (DAYS) |   716          676          582          462       |   ---          ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.248N     P=0.243      P=0.047 *    P=0.456N   |  P=0.226        (e)          (e)        P=0.323    |
|INCIDENTAL TUMOR       |  P=0.148N     P=0.169      P=0.097      P=0.334N   |  P=0.226        (e)          (e)        P=0.323    |
|LOGISTIC REGRESSION    |  P=0.152N     P=0.184      P=0.208      P=0.333N   |  P=0.226        (e)          (e)        P=0.323    |
|COCHRAN-ARMITAGE       |  P=0.164N                                          |  P=0.156                                           |
|FISHER EXACT           |               P=0.304      P=0.446      P=0.327N   |                 (e)          (e)        P=0.345    |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE   5
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 11/72 (15%)   4/20 (20%)  11/98 (11%)   7/93 (8%)  |  5/65 (8%)    0/12 (0%)    2/39 (5%)    2/93 (2%)  |
|ADJUSTED (b)           |  29.6%        52.4%        42.0%        10.6%      |  11.1%         0.0%        33.8%         3.1%      |
|TERMINAL (d)           |  9/33 (27%)   2/4 (50%)    5/13 (38%)   1/42 (2%)  |  5/45 (11%)   0/2 (0%)     1/3 (33%)    2/65 (3%)  |
|FIRST INCIDENCE (DAYS) |   710          676          582          462       |   729 (T)      ---          615          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.092N     P=0.256      P=0.150      P=0.193N   |  P=0.076N     P=0.747N     P=0.239      P=0.098N   |
|INCIDENTAL TUMOR       |  P=0.041N*    P=0.171      P=0.273      P=0.099N   |  P=0.070N     P=0.747N     P=0.281      P=0.098N   |
|LOGISTIC REGRESSION    |  P=0.047N*    P=0.208      P=0.507      P=0.096N   |  P=0.083N     P=0.747N     P=0.623      P=0.098N   |
|COCHRAN-ARMITAGE       |  P=0.056N                                          |  P=0.111N                                          |
|FISHER EXACT           |               P=0.418      P=0.291N     P=0.092N   |               P=0.418N     P=0.473N     P=0.103N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/100 (1%)   0/50 (0%)    2/150 (1%)   0/100 (0%) |  0/100 (0%)   0/50 (0%)    0/150 (0%)   0/100 (0%) |
|ADJUSTED (b)           |   1.7%         0.0%         3.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/59 (2%)    0/34 (0%)    1/63 (2%)    0/43 (0%)  |  0/79 (0%)    0/40 (0%)    0/113 (0%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      ---          707          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.486N     P=0.610N     P=0.529      P=0.563N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.448N     P=0.610N     P=0.589      P=0.563N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.460N     P=0.610N     P=0.566      P=0.563N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.402N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.667N     P=0.649      P=0.500N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE   6
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Jejunum                                                                                                         |
|     Leiomyoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/100 (0%)   0/50 (0%)    0/150 (0%)   2/100 (2%) |  0/100 (0%)   0/50 (0%)    0/150 (0%)   0/100 (0%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         3.5%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/59 (0%)    0/34 (0%)    0/63 (0%)    1/43 (2%)  |  0/79 (0%)    0/40 (0%)    0/113 (0%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          603       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.038 *      (e)          (e)        P=0.205    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.061        (e)          (e)        P=0.273    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.049 *      (e)          (e)        P=0.248    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.047 *                                         |    (e)                                             |
|FISHER EXACT           |                 (e)          (e)        P=0.249    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/70 (7%)    0/16 (0%)    2/88 (2%)    3/99 (3%)  |  0/61 (0%)    0/11 (0%)    0/34 (0%)    0/99 (0%)  |
|ADJUSTED (b)           |  12.1%         0.0%         1.7%         6.1%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  3/30 (10%)   0/0          0/3 (0%)     2/43 (5%)  |  0/40 (0%)    0/1 (0%)     0/0          0/67 (0%)  |
|FIRST INCIDENCE (DAYS) |   507          ---          573          674       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.290N     P=0.399N     P=0.470N     P=0.271N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.220N     P=0.408N     P=0.311N     P=0.215N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.265N     P=0.317N     P=0.134N     P=0.193N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.278N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.348N     P=0.139N     P=0.191N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE   7
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/70 (4%)    0/16 (0%)    0/88 (0%)    0/99 (0%)  |  1/61 (2%)    0/11 (0%)    0/34 (0%)    0/99 (0%)  |
|ADJUSTED (b)           |  10.0%         0.0%         0.0%         0.0%      |   2.5%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  3/30 (10%)   0/0          0/3 (0%)     0/43 (0%)  |  1/40 (3%)    0/1 (0%)     0/0          0/67 (0%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      ---          ---          ---       |   729 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.045N*      (e)        P=0.681N     P=0.066N   |  P=0.276N     P=0.999N       (e)        P=0.397N   |
|INCIDENTAL TUMOR       |  P=0.045N*      (e)        P=0.681N     P=0.066N   |  P=0.276N     P=0.999N       (e)        P=0.397N   |
|LOGISTIC REGRESSION    |  P=0.045N*      (e)        P=0.681N     P=0.066N   |  P=0.276N     P=0.999N       (e)        P=0.397N   |
|COCHRAN-ARMITAGE       |  P=0.063N                                          |  P=0.321N                                          |
|FISHER EXACT           |               P=0.535N     P=0.085N     P=0.069N   |               P=0.847N     P=0.642N     P=0.381N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/70 (11%)   0/16 (0%)    2/88 (2%)    3/99 (3%)  |  1/61 (2%)    0/11 (0%)    0/34 (0%)    0/99 (0%)  |
|ADJUSTED (b)           |  21.9%         0.0%         1.7%         6.1%      |   2.5%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  6/30 (20%)   0/0          0/3 (0%)     2/43 (5%)  |  1/40 (3%)    0/1 (0%)     0/0          0/67 (0%)  |
|FIRST INCIDENCE (DAYS) |   507          ---          573          674       |   729 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.055N     P=0.399N     P=0.382N     P=0.049N*  |  P=0.276N     P=0.999N       (e)        P=0.397N   |
|INCIDENTAL TUMOR       |  P=0.036N*    P=0.408N     P=0.243N     P=0.035N*  |  P=0.276N     P=0.999N       (e)        P=0.397N   |
|LOGISTIC REGRESSION    |  P=0.058N     P=0.227N     P=0.037N*    P=0.032N*  |  P=0.276N     P=0.999N       (e)        P=0.397N   |
|COCHRAN-ARMITAGE       |  P=0.067N                                          |  P=0.321N                                          |
|FISHER EXACT           |               P=0.178N     P=0.021N*    P=0.032N*  |               P=0.847N     P=0.642N     P=0.381N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE   8
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/74 (1%)    0/20 (0%)    2/101 (2%)   1/100 (1%) |  0/60 (0%)    0/11 (0%)    0/37 (0%)    0/100 (0%) |
|ADJUSTED (b)           |   3.0%         0.0%         2.0%         2.3%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/33 (3%)    0/4 (0%)     0/14 (0%)    1/43 (2%)  |  0/40 (0%)    0/1 (0%)     0/0          0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      ---          626          727 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.616N     P=0.897N     P=0.465      P=0.702N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.535N     P=0.897N     P=0.580      P=0.702N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.562N     P=0.897N     P=0.562      P=0.702N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.579N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.787N     P=0.615      P=0.671N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/74 (3%)    0/20 (0%)    2/101 (2%)   1/100 (1%) |  0/60 (0%)    0/11 (0%)    0/37 (0%)    0/100 (0%) |
|ADJUSTED (b)           |   6.1%         0.0%         2.0%         2.3%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  2/33 (6%)    0/4 (0%)     0/14 (0%)    1/43 (2%)  |  0/40 (0%)    0/1 (0%)     0/0          0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      ---          626          727 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.391N     P=0.744N     P=0.593      P=0.408N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.324N     P=0.744N     P=0.692      P=0.408N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.354N     P=0.744N     P=0.669N     P=0.408N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.370N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.618N     P=0.565N     P=0.388N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE   9
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/100 (6%)   5/50 (10%)  39/149 (26%) 76/100 (76%)|  0/100 (0%)   3/50 (6%)   67/150 (45%) 83/100 (83%)|
|ADJUSTED (b)           |  10.2%        13.6%        46.5%        96.1%      |   0.0%         7.2%        56.0%        94.3%      |
|TERMINAL (d)           |  6/59 (10%)   3/34 (9%)   23/63 (37%)  40/43 (93%) |  0/79 (0%)    2/40 (5%)   61/113 (54%) 63/68 (93%) |
|FIRST INCIDENCE (DAYS) |   727 (T)      702          484          515       |   ---          719          565          312       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.382      P<0.001 **   P<0.001 ** |  P<0.001 **   P=0.035 *    P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.333      P<0.001 **   P<0.001 ** |  P<0.001 **   P=0.031 *    P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.358      P<0.001 **   P<0.001 ** |  P<0.001 **   P=0.035 *    P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.283      P<0.001 **   P<0.001 ** |               P=0.036 *    P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/100 (0%)   1/50 (2%)    4/149 (3%)  42/100 (42%)|  0/100 (0%)   0/50 (0%)   11/150 (7%)  26/100 (26%)|
|ADJUSTED (b)           |   0.0%         2.9%         5.2%        67.4%      |   0.0%         0.0%         9.0%        33.1%      |
|TERMINAL (d)           |  0/59 (0%)    1/34 (3%)    2/63 (3%)   24/43 (56%) |  0/79 (0%)    0/40 (0%)    7/113 (6%)  17/68 (25%) |
|FIRST INCIDENCE (DAYS) |   ---          727 (T)      678          575       |   ---          ---          529          599       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.390      P=0.088      P<0.001 ** |  P<0.001 **     (e)        P=0.007 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.390      P=0.116      P<0.001 ** |  P<0.001 **     (e)        P=0.008 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.390      P=0.109      P<0.001 ** |  P<0.001 **     (e)        P=0.007 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.333      P=0.126      P<0.001 ** |                 (e)        P=0.003 **   P<0.001 ** |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  10
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/100 (6%)   6/50 (12%)  42/149 (28%) 82/100 (82%)|  0/100 (0%)   3/50 (6%)   73/150 (49%) 86/100 (86%)|
|ADJUSTED (b)           |  10.2%        16.4%        48.9%        98.8%      |   0.0%         7.2%        60.0%        95.5%      |
|TERMINAL (d)           |  6/59 (10%)   4/34 (12%)  24/63 (38%)  42/43 (98%) |  0/79 (0%)    2/40 (5%)   65/113 (58%) 64/68 (94%) |
|FIRST INCIDENCE (DAYS) |   727 (T)      702          484          515       |   ---          719          529          312       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.247      P<0.001 **   P<0.001 ** |  P<0.001 **   P=0.035 *    P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.207      P<0.001 **   P<0.001 ** |  P<0.001 **   P=0.031 *    P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.225      P<0.001 **   P<0.001 ** |  P<0.001 **   P=0.035 *    P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.168      P<0.001 **   P<0.001 ** |               P=0.036 *    P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/100 (6%)   6/50 (12%)  42/149 (28%) 82/100 (82%)|  0/100 (0%)   3/50 (6%)   73/150 (49%) 86/100 (86%)|
|ADJUSTED (b)           |  10.2%        16.4%        48.9%        98.8%      |   0.0%         7.2%        60.0%        95.5%      |
|TERMINAL (d)           |  6/59 (10%)   4/34 (12%)  24/63 (38%)  42/43 (98%) |  0/79 (0%)    2/40 (5%)   65/113 (58%) 64/68 (94%) |
|FIRST INCIDENCE (DAYS) |   727 (T)      702          484          515       |   ---          719          529          312       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.247      P<0.001 **   P<0.001 ** |  P<0.001 **   P=0.035 *    P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.207      P<0.001 **   P<0.001 ** |  P<0.001 **   P=0.031 *    P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.225      P<0.001 **   P<0.001 ** |  P<0.001 **   P=0.035 *    P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.168      P<0.001 **   P<0.001 ** |               P=0.036 *    P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  11
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/71 (3%)    2/17 (12%)   2/91 (2%)    5/99 (5%)  |  0/61 (0%)    0/11 (0%)    0/34 (0%)    2/97 (2%)  |
|ADJUSTED (b)           |   6.7%       100.0%        20.7%        10.6%      |   0.0%         0.0%         0.0%         3.1%      |
|TERMINAL (d)           |  2/30 (7%)    1/1 (100%)   1/5 (20%)    4/42 (10%) |  0/40 (0%)    0/2 (0%)     0/0          2/65 (3%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      676          630          605       |   ---          ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.520      P=0.031 *    P=0.259      P=0.345    |  P=0.256        (e)          (e)        P=0.351    |
|INCIDENTAL TUMOR       |  P=0.585N     P=0.018 *    P=0.312      P=0.395    |  P=0.256        (e)          (e)        P=0.351    |
|LOGISTIC REGRESSION    |  P=0.468      P=0.059      P=0.613      P=0.360    |  P=0.256        (e)          (e)        P=0.351    |
|COCHRAN-ARMITAGE       |  P=0.398                                           |  P=0.179                                           |
|FISHER EXACT           |               P=0.167      P=0.591N     P=0.379    |                 (e)          (e)        P=0.375    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/71 (0%)    1/17 (6%)    2/91 (2%)    0/99 (0%)  |  0/61 (0%)    0/11 (0%)    0/34 (0%)    0/97 (0%)  |
|ADJUSTED (b)           |   0.0%         2.0%         2.7%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/30 (0%)    0/1 (0%)     0/5 (0%)     0/42 (0%)  |  0/40 (0%)    0/2 (0%)     0/0          0/65 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          436          695          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.509N     P=0.364      P=0.273        (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.408N     P=0.398      P=0.386        (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.351N     P=0.286      P=0.165        (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.330N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.193      P=0.314        (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  12
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/71 (3%)    3/17 (18%)   4/91 (4%)    5/99 (5%)  |  0/61 (0%)    0/11 (0%)    0/34 (0%)    2/97 (2%)  |
|ADJUSTED (b)           |   6.7%       100.0%        22.8%        10.6%      |   0.0%         0.0%         0.0%         3.1%      |
|TERMINAL (d)           |  2/30 (7%)    1/1 (100%)   1/5 (20%)    4/42 (10%) |  0/40 (0%)    0/2 (0%)     0/0          2/65 (3%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      436          630          605       |   ---          ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.568N     P=0.010 **   P=0.086      P=0.345    |  P=0.256        (e)          (e)        P=0.351    |
|INCIDENTAL TUMOR       |  P=0.457N     P=0.008 **   P=0.145      P=0.395    |  P=0.256        (e)          (e)        P=0.351    |
|LOGISTIC REGRESSION    |  P=0.548N     P=0.040 *    P=0.218      P=0.360    |  P=0.256        (e)          (e)        P=0.351    |
|COCHRAN-ARMITAGE       |  P=0.579                                           |  P=0.179                                           |
|FISHER EXACT           |               P=0.048 *    P=0.464      P=0.379    |                 (e)          (e)        P=0.375    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/71 (0%)    0/17 (0%)    2/91 (2%)    0/99 (0%)  |  0/61 (0%)    0/11 (0%)    0/34 (0%)    0/97 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%        40.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/30 (0%)    0/1 (0%)     2/5 (40%)    0/42 (0%)  |  0/40 (0%)    0/2 (0%)     0/0          0/65 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          727 (T)      ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.428N       (e)        P=0.006 **     (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.428N       (e)        P=0.006 **     (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.428N       (e)        P=0.006 **     (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.539N                                          |    (e)                                             |
|FISHER EXACT           |                 (e)        P=0.314        (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  13
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/100 (1%)   2/50 (4%)    4/150 (3%)   0/100 (0%) | 11/100 (11%)  3/50 (6%)   20/150 (13%)  6/100 (6%) |
|ADJUSTED (b)           |   1.7%         5.9%         5.8%         0.0%      |  13.5%         7.5%        16.5%         8.2%      |
|TERMINAL (d)           |  1/59 (2%)    2/34 (6%)    2/63 (3%)    0/43 (0%)  |  9/79 (11%)   3/40 (8%)   14/113 (12%)  4/68 (6%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      727 (T)      693          ---       |   635          729 (T)      608          682       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.296N     P=0.313      P=0.215      P=0.563N   |  P=0.264N     P=0.238N     P=0.322      P=0.234N   |
|INCIDENTAL TUMOR       |  P=0.256N     P=0.313      P=0.279      P=0.563N   |  P=0.152N     P=0.243N     P=0.361      P=0.157N   |
|LOGISTIC REGRESSION    |  P=0.267N     P=0.313      P=0.247      P=0.563N   |  P=0.188N     P=0.231N     P=0.350      P=0.175N   |
|COCHRAN-ARMITAGE       |  P=0.197N                                          |  P=0.166N                                          |
|FISHER EXACT           |               P=0.258      P=0.335      P=0.500N   |               P=0.249N     P=0.366      P=0.155N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/100 (1%)   2/50 (4%)    4/150 (3%)   0/100 (0%) | 11/100 (11%)  3/50 (6%)   21/150 (14%)  7/100 (7%) |
|ADJUSTED (b)           |   1.7%         5.9%         5.8%         0.0%      |  13.5%         7.5%        17.4%         9.7%      |
|TERMINAL (d)           |  1/59 (2%)    2/34 (6%)    2/63 (3%)    0/43 (0%)  |  9/79 (11%)   3/40 (8%)   15/113 (13%)  5/68 (7%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      727 (T)      693          ---       |   635          729 (T)      608          682       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.296N     P=0.313      P=0.215      P=0.563N   |  P=0.361N     P=0.238N     P=0.271      P=0.328N   |
|INCIDENTAL TUMOR       |  P=0.256N     P=0.313      P=0.279      P=0.563N   |  P=0.228N     P=0.243N     P=0.305      P=0.238N   |
|LOGISTIC REGRESSION    |  P=0.267N     P=0.313      P=0.247      P=0.563N   |  P=0.270N     P=0.231N     P=0.295      P=0.257N   |
|COCHRAN-ARMITAGE       |  P=0.197N                                          |  P=0.239N                                          |
|FISHER EXACT           |               P=0.258      P=0.335      P=0.500N   |               P=0.249N     P=0.311      P=0.230N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  14
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/100 (1%)   2/50 (4%)    4/150 (3%)   0/100 (0%) | 12/100 (12%)  3/50 (6%)   21/150 (14%)  7/100 (7%) |
|ADJUSTED (b)           |   1.7%         5.9%         5.8%         0.0%      |  14.7%         7.5%        17.4%         9.7%      |
|TERMINAL (d)           |  1/59 (2%)    2/34 (6%)    2/63 (3%)    0/43 (0%)  | 10/79 (13%)   3/40 (8%)   15/113 (13%)  5/68 (7%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      727 (T)      693          ---       |   635          729 (T)      608          682       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.296N     P=0.313      P=0.215      P=0.563N   |  P=0.306N     P=0.189N     P=0.351      P=0.256N   |
|INCIDENTAL TUMOR       |  P=0.256N     P=0.313      P=0.279      P=0.563N   |  P=0.185N     P=0.192N     P=0.390      P=0.179N   |
|LOGISTIC REGRESSION    |  P=0.267N     P=0.313      P=0.247      P=0.563N   |  P=0.221N     P=0.181N     P=0.381      P=0.192N   |
|COCHRAN-ARMITAGE       |  P=0.197N                                          |  P=0.193N                                          |
|FISHER EXACT           |               P=0.258      P=0.335      P=0.500N   |               P=0.196N     P=0.398      P=0.167N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/71 (3%)    0/16 (0%)    0/88 (0%)    0/99 (0%)  |  0/61 (0%)    0/11 (0%)    0/35 (0%)    0/98 (0%)  |
|ADJUSTED (b)           |   2.1%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/30 (0%)    0/0          0/3 (0%)     0/42 (0%)  |  0/40 (0%)    0/1 (0%)     0/0          0/66 (0%)  |
|FIRST INCIDENCE (DAYS) |   367          ---          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.206N     P=0.399N     P=0.161N     P=0.242N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.133N     P=0.435N     P=0.079N     P=0.124N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.219N     P=0.407N     P=0.183N     P=0.210N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.147N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.664N     P=0.198N     P=0.173N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  15
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip)                                                                           |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/100 (0%)   0/50 (0%)    2/150 (1%)   0/100 (0%) |  0/100 (0%)   0/50 (0%)    2/150 (1%)   0/100 (0%) |
|ADJUSTED (b)           |   0.0%         0.0%         2.3%         0.0%      |   0.0%         0.0%         1.5%         0.0%      |
|TERMINAL (d)           |  0/59 (0%)    0/34 (0%)    0/63 (0%)    0/43 (0%)  |  0/79 (0%)    0/40 (0%)    0/113 (0%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          693          ---       |   ---          ---          429          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.709N       (e)        P=0.282        (e)      |  P=0.677N       (e)        P=0.334        (e)      |
|INCIDENTAL TUMOR       |  P=0.641N       (e)        P=0.391        (e)      |  P=0.567N       (e)        P=0.377        (e)      |
|LOGISTIC REGRESSION    |  P=0.674N       (e)        P=0.319        (e)      |  P=0.683N       (e)        P=0.359        (e)      |
|COCHRAN-ARMITAGE       |  P=0.664N                                          |  P=0.664N                                          |
|FISHER EXACT           |                 (e)        P=0.359        (e)      |                 (e)        P=0.359        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip)                                                                           |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/100 (0%)   0/50 (0%)    2/150 (1%)   0/100 (0%) |  1/100 (1%)   1/50 (2%)    2/150 (1%)   0/100 (0%) |
|ADJUSTED (b)           |   0.0%         0.0%         2.3%         0.0%      |   1.3%         2.5%         1.5%         0.0%      |
|TERMINAL (d)           |  0/59 (0%)    0/34 (0%)    0/63 (0%)    0/43 (0%)  |  1/79 (1%)    1/40 (3%)    0/113 (0%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          693          ---       |   729 (T)      729 (T)      429          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.709N       (e)        P=0.282        (e)      |  P=0.300N     P=0.602      P=0.634      P=0.530N   |
|INCIDENTAL TUMOR       |  P=0.641N       (e)        P=0.391        (e)      |  P=0.240N     P=0.602      P=0.673      P=0.530N   |
|LOGISTIC REGRESSION    |  P=0.674N       (e)        P=0.319        (e)      |  P=0.271N     P=0.602      P=0.667      P=0.530N   |
|COCHRAN-ARMITAGE       |  P=0.664N                                          |  P=0.275N                                          |
|FISHER EXACT           |                 (e)        P=0.359        (e)      |               P=0.557      P=0.649      P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  16
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/70 (1%)    1/16 (6%)    5/90 (6%)    0/99 (0%)  |  0/61 (0%)    0/11 (0%)    0/34 (0%)    0/100 (0%) |
|ADJUSTED (b)           |   3.3%         0.0%        23.1%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/30 (3%)    0/0          1/5 (20%)    0/43 (0%)  |  0/40 (0%)    0/1 (0%)     0/0          0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      721          510          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.215N     P=0.401      P=0.039 *    P=0.428N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.152N     P=0.310      P=0.071      P=0.428N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.123N     P=0.125      P=0.141      P=0.428N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.129N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.339      P=0.175      P=0.414N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/64 (0%)    0/16 (0%)    3/87 (3%)    2/96 (2%)  |  2/55 (4%)    0/11 (0%)    0/33 (0%)    0/95 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%        34.6%         3.4%      |   5.6%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/23 (0%)    0/0          1/3 (33%)    0/40 (0%)  |  2/36 (6%)    0/1 (0%)     0/0          0/63 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          626          679       |   729 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.253        (e)        P=0.053      P=0.198    |  P=0.085N     P=0.976N       (e)        P=0.127N   |
|INCIDENTAL TUMOR       |  P=0.353        (e)        P=0.079      P=0.262    |  P=0.085N     P=0.976N       (e)        P=0.127N   |
|LOGISTIC REGRESSION    |  P=0.420        (e)        P=0.138      P=0.334    |  P=0.085N     P=0.976N       (e)        P=0.127N   |
|COCHRAN-ARMITAGE       |  P=0.388                                           |  P=0.113N                                          |
|FISHER EXACT           |                 (e)        P=0.188      P=0.358    |               P=0.692N     P=0.388N     P=0.133N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  17
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 20/77 (26%)   9/22 (41%)  32/96 (33%)  13/97 (13%) | 40/84 (48%)  19/27 (70%)  42/84 (50%)   9/100 (9%) |
|ADJUSTED (b)           |  39.3%       100.0%        65.9%        23.4%      |  54.1%        84.2%        72.3%        13.2%      |
|TERMINAL (d)           | 12/37 (32%)   6/6 (100%)   6/11 (55%)   6/43 (14%) | 31/63 (49%)  14/17 (82%)  33/47 (70%)   9/68 (13%) |
|FIRST INCIDENCE (DAYS) |   584          581          546          450       |   523          487          576          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.045N*    P=0.139      P=0.004 **   P=0.131N   |  P<0.001N**   P=0.050 *    P=0.148      P<0.001N** |
|INCIDENTAL TUMOR       |  P=0.004N**   P=0.040 *    P=0.036 *    P=0.045N*  |  P<0.001N**   P=0.019 *    P=0.189      P<0.001N** |
|LOGISTIC REGRESSION    |  P=0.002N**   P=0.061      P=0.030 *    P=0.032N*  |  P<0.001N**   P=0.022 *    P=0.224      P<0.001N** |
|COCHRAN-ARMITAGE       |  P=0.003N**                                        |  P<0.001N**                                        |
|FISHER EXACT           |               P=0.138      P=0.189      P=0.029N*  |               P=0.032 *    P=0.439      P<0.001N** |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/77 (0%)    0/22 (0%)    0/96 (0%)    1/97 (1%)  |  0/84 (0%)    0/27 (0%)    3/84 (4%)    0/100 (0%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         2.3%      |   0.0%         0.0%         5.0%         0.0%      |
|TERMINAL (d)           |  0/37 (0%)    0/6 (0%)     0/11 (0%)    0/43 (0%)  |  0/63 (0%)    0/17 (0%)    2/47 (4%)    0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          726       |   ---          ---          707          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.193        (e)          (e)        P=0.441    |  P=0.550N       (e)        P=0.110        (e)      |
|INCIDENTAL TUMOR       |  P=0.236        (e)          (e)        P=0.515    |  P=0.493N       (e)        P=0.114        (e)      |
|LOGISTIC REGRESSION    |  P=0.345        (e)          (e)        P=0.534    |  P=0.503N       (e)        P=0.098        (e)      |
|COCHRAN-ARMITAGE       |  P=0.297                                           |  P=0.502N                                          |
|FISHER EXACT           |                 (e)          (e)        P=0.557    |                 (e)        P=0.123        (e)      |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  18
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/100 (2%)   1/50 (2%)    0/150 (0%)   0/100 (0%) |  0/100 (0%)   0/50 (0%)    0/150 (0%)   0/100 (0%) |
|ADJUSTED (b)           |   3.4%         2.9%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  2/59 (3%)    1/34 (3%)    0/63 (0%)    0/43 (0%)  |  0/79 (0%)    0/40 (0%)    0/113 (0%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      727 (T)      ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.182N     P=0.687N     P=0.225N     P=0.311N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.182N     P=0.687N     P=0.225N     P=0.311N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.182N     P=0.687N     P=0.225N     P=0.311N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.132N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.742N     P=0.159N     P=0.249N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/100 (1%)   0/50 (0%)    1/150 (1%)   4/100 (4%) |  1/100 (1%)   0/50 (0%)    0/150 (0%)   1/100 (1%) |
|ADJUSTED (b)           |   1.7%         0.0%         1.6%         9.3%      |   1.3%         0.0%         0.0%         1.5%      |
|TERMINAL (d)           |  1/59 (2%)    0/34 (0%)    1/63 (2%)    4/43 (9%)  |  1/79 (1%)    0/40 (0%)    0/113 (0%)   1/68 (1%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      ---          727 (T)      727 (T)   |   729 (T)      ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.014 *    P=0.610N     P=0.747N     P=0.099    |  P=0.549      P=0.636N     P=0.429N     P=0.727    |
|INCIDENTAL TUMOR       |  P=0.014 *    P=0.610N     P=0.747N     P=0.099    |  P=0.549      P=0.636N     P=0.429N     P=0.727    |
|LOGISTIC REGRESSION    |  P=0.014 *    P=0.610N     P=0.747N     P=0.099    |  P=0.549      P=0.636N     P=0.429N     P=0.727    |
|COCHRAN-ARMITAGE       |  P=0.034 *                                         |  P=0.581                                           |
|FISHER EXACT           |               P=0.667N     P=0.641N     P=0.184    |               P=0.667N     P=0.400N     P=0.751N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  19
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/100 (1%)   0/50 (0%)    1/150 (1%)   3/100 (3%) |  1/100 (1%)   0/50 (0%)    0/150 (0%)   1/100 (1%) |
|ADJUSTED (b)           |   1.7%         0.0%         1.6%         7.0%      |   1.3%         0.0%         0.0%         1.5%      |
|TERMINAL (d)           |  1/59 (2%)    0/34 (0%)    1/63 (2%)    3/43 (7%)  |  1/79 (1%)    0/40 (0%)    0/113 (0%)   1/68 (1%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      ---          727 (T)      727 (T)   |   729 (T)      ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.056      P=0.610N     P=0.747N     P=0.201    |  P=0.549      P=0.636N     P=0.429N     P=0.727    |
|INCIDENTAL TUMOR       |  P=0.056      P=0.610N     P=0.747N     P=0.201    |  P=0.549      P=0.636N     P=0.429N     P=0.727    |
|LOGISTIC REGRESSION    |  P=0.056      P=0.610N     P=0.747N     P=0.201    |  P=0.549      P=0.636N     P=0.429N     P=0.727    |
|COCHRAN-ARMITAGE       |  P=0.103                                           |  P=0.581                                           |
|FISHER EXACT           |               P=0.667N     P=0.641N     P=0.311    |               P=0.667N     P=0.400N     P=0.751N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/100 (0%)   0/50 (0%)    2/150 (1%)   0/100 (0%) |  1/100 (1%)   0/50 (0%)    0/150 (0%)   0/100 (0%) |
|ADJUSTED (b)           |   0.0%         0.0%         2.3%         0.0%      |   1.3%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/59 (0%)    0/34 (0%)    1/63 (2%)    0/43 (0%)  |  1/79 (1%)    0/40 (0%)    0/113 (0%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          529          ---       |   729 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.699N       (e)        P=0.290        (e)      |  P=0.465N     P=0.636N     P=0.429N     P=0.530N   |
|INCIDENTAL TUMOR       |  P=0.666N       (e)        P=0.348        (e)      |  P=0.465N     P=0.636N     P=0.429N     P=0.530N   |
|LOGISTIC REGRESSION    |  P=0.643N       (e)        P=0.360        (e)      |  P=0.465N     P=0.636N     P=0.429N     P=0.530N   |
|COCHRAN-ARMITAGE       |  P=0.664N                                          |  P=0.443N                                          |
|FISHER EXACT           |                 (e)        P=0.359        (e)      |               P=0.667N     P=0.400N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  20
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma, Basal Cell Carcinoma, or Basal Cell Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/100 (0%)   0/50 (0%)    2/150 (1%)   0/100 (0%) |  2/100 (2%)   0/50 (0%)    0/150 (0%)   0/100 (0%) |
|ADJUSTED (b)           |   0.0%         0.0%         2.3%         0.0%      |   2.4%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/59 (0%)    0/34 (0%)    1/63 (2%)    0/43 (0%)  |  1/79 (1%)    0/40 (0%)    0/113 (0%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          529          ---       |   656          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.699N       (e)        P=0.290        (e)      |  P=0.216N     P=0.398N     P=0.165N     P=0.260N   |
|INCIDENTAL TUMOR       |  P=0.666N       (e)        P=0.348        (e)      |  P=0.179N     P=0.411N     P=0.152N     P=0.201N   |
|LOGISTIC REGRESSION    |  P=0.643N       (e)        P=0.360        (e)      |  P=0.202N     P=0.397N     P=0.153N     P=0.235N   |
|COCHRAN-ARMITAGE       |  P=0.664N                                          |  P=0.204N                                          |
|FISHER EXACT           |                 (e)        P=0.359        (e)      |               P=0.443N     P=0.159N     P=0.249N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma,                                                                |
|     Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/100 (3%)   1/50 (2%)    3/150 (2%)   4/100 (4%) |  3/100 (3%)   0/50 (0%)    0/150 (0%)   1/100 (1%) |
|ADJUSTED (b)           |   5.1%         2.9%         3.9%         9.3%      |   3.6%         0.0%         0.0%         1.5%      |
|TERMINAL (d)           |  3/59 (5%)    1/34 (3%)    2/63 (3%)    4/43 (9%)  |  2/79 (3%)    0/40 (0%)    0/113 (0%)   1/68 (1%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      727 (T)      529          727 (T)   |   656          ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.205      P=0.516N     P=0.606N     P=0.332    |  P=0.422N     P=0.267N     P=0.068N     P=0.351N   |
|INCIDENTAL TUMOR       |  P=0.217      P=0.516N     P=0.566N     P=0.332    |  P=0.378N     P=0.275N     P=0.063N     P=0.303N   |
|LOGISTIC REGRESSION    |  P=0.280      P=0.516N     P=0.492N     P=0.332    |  P=0.391N     P=0.268N     P=0.062N     P=0.313N   |
|COCHRAN-ARMITAGE       |  P=0.342                                           |  P=0.387N                                          |
|FISHER EXACT           |               P=0.593N     P=0.456N     P=0.500    |               P=0.293N     P=0.063N     P=0.311N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  21
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/100 (8%)   6/50 (12%)   7/150 (5%)   7/100 (7%) |  1/100 (1%)   0/50 (0%)    0/150 (0%)   0/100 (0%) |
|ADJUSTED (b)           |  12.9%        15.9%         7.9%        14.4%      |   1.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  7/59 (12%)   3/34 (9%)    1/63 (2%)    4/43 (9%)  |  0/79 (0%)    0/40 (0%)    0/113 (0%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   651          654          510          684       |   579          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.522      P=0.409      P=0.388N     P=0.483    |  P=0.447N     P=0.638N     P=0.425N     P=0.506N   |
|INCIDENTAL TUMOR       |  P=0.456N     P=0.331      P=0.231N     P=0.553    |  P=0.388N     P=0.638N     P=0.362N     P=0.419N   |
|LOGISTIC REGRESSION    |  P=0.457N     P=0.349      P=0.234N     P=0.572    |  P=0.452N     P=0.574N     P=0.393N     P=0.473N   |
|COCHRAN-ARMITAGE       |  P=0.381N                                          |  P=0.443N                                          |
|FISHER EXACT           |               P=0.303      P=0.206N     P=0.500N   |               P=0.667N     P=0.400N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/100 (6%)   3/50 (6%)    4/150 (3%)   2/100 (2%) |  0/100 (0%)   1/50 (2%)    3/150 (2%)   0/100 (0%) |
|ADJUSTED (b)           |   8.3%         7.0%         2.9%         3.4%      |   0.0%         2.5%         2.4%         0.0%      |
|TERMINAL (d)           |  3/59 (5%)    1/34 (3%)    0/63 (0%)    1/43 (2%)  |  0/79 (0%)    1/40 (3%)    2/113 (2%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   571          436          455          588       |   ---          729 (T)      278          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.141N     P=0.599N     P=0.229N     P=0.207N   |  P=0.472N     P=0.364      P=0.197        (e)      |
|INCIDENTAL TUMOR       |  P=0.041N*    P=0.591      P=0.087N     P=0.102N   |  P=0.488N     P=0.364      P=0.168        (e)      |
|LOGISTIC REGRESSION    |  P=0.066N     P=0.622      P=0.103N     P=0.122N   |  P=0.440N     P=0.364      P=0.221        (e)      |
|COCHRAN-ARMITAGE       |  P=0.099N                                          |  P=0.438N                                          |
|FISHER EXACT           |               P=0.653N     P=0.161N     P=0.140N   |               P=0.333      P=0.214        (e)      |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  22
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Lipoma                                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/100 (0%)   0/50 (0%)    0/150 (0%)   1/100 (1%) |  0/100 (0%)   0/50 (0%)    0/150 (0%)   2/100 (2%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         2.0%      |   0.0%         0.0%         0.0%         2.9%      |
|TERMINAL (d)           |  0/59 (0%)    0/34 (0%)    0/63 (0%)    0/43 (0%)  |  0/79 (0%)    0/40 (0%)    0/113 (0%)   2/68 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          707       |   ---          ---          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.195        (e)          (e)        P=0.447    |  P=0.036 *      (e)          (e)        P=0.207    |
|INCIDENTAL TUMOR       |  P=0.240        (e)          (e)        P=0.522    |  P=0.036 *      (e)          (e)        P=0.207    |
|LOGISTIC REGRESSION    |  P=0.214        (e)          (e)        P=0.478    |  P=0.036 *      (e)          (e)        P=0.207    |
|COCHRAN-ARMITAGE       |  P=0.230                                           |  P=0.047 *                                         |
|FISHER EXACT           |                 (e)          (e)        P=0.500    |                 (e)          (e)        P=0.249    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibroma or Fibroma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/100 (8%)   6/50 (12%)   7/150 (5%)   8/100 (8%) |  1/100 (1%)   0/50 (0%)    0/150 (0%)   0/100 (0%) |
|ADJUSTED (b)           |  12.9%        15.9%         7.9%        16.3%      |   1.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  7/59 (12%)   3/34 (9%)    1/63 (2%)    4/43 (9%)  |  0/79 (0%)    0/40 (0%)    0/113 (0%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   651          654          510          684       |   579          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.390      P=0.409      P=0.388N     P=0.368    |  P=0.447N     P=0.638N     P=0.425N     P=0.506N   |
|INCIDENTAL TUMOR       |  P=0.558      P=0.331      P=0.231N     P=0.452    |  P=0.388N     P=0.638N     P=0.362N     P=0.419N   |
|LOGISTIC REGRESSION    |  P=0.547      P=0.349      P=0.234N     P=0.451    |  P=0.452N     P=0.574N     P=0.393N     P=0.473N   |
|COCHRAN-ARMITAGE       |  P=0.506N                                          |  P=0.443N                                          |
|FISHER EXACT           |               P=0.303      P=0.206N     P=0.602N   |               P=0.667N     P=0.400N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  23
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, Sarcoma,                                                                                   |
|     Neurofibroma, or Fibroma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 14/100 (14%)  9/50 (18%)  12/150 (8%)  10/100 (10%)|  2/100 (2%)   1/50 (2%)    3/150 (2%)   0/100 (0%) |
|ADJUSTED (b)           |  20.7%        22.0%        11.9%        19.4%      |   2.0%         2.5%         2.4%         0.0%      |
|TERMINAL (d)           | 10/59 (17%)   4/34 (12%)   1/63 (2%)    5/43 (12%) |  0/79 (0%)    1/40 (3%)    2/113 (2%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   571          436          455          588       |   334          729 (T)      278          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.388N     P=0.453      P=0.243N     P=0.501N   |  P=0.184N     P=0.729      P=0.665      P=0.244N   |
|INCIDENTAL TUMOR       |  P=0.146N     P=0.329      P=0.068N     P=0.331N   |  P=0.172N     P=0.654N     P=0.659      P=0.196N   |
|LOGISTIC REGRESSION    |  P=0.165N     P=0.335      P=0.073N     P=0.316N   |  P=0.162N     P=0.618N     P=0.639N     P=0.155N   |
|COCHRAN-ARMITAGE       |  P=0.178N                                          |  P=0.166N                                          |
|FISHER EXACT           |               P=0.339      P=0.096N     P=0.257N   |               P=0.742N     P=0.665N     P=0.249N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, or Sarcoma                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/100 (6%)   3/50 (6%)    5/150 (3%)   2/100 (2%) |  1/100 (1%)   1/50 (2%)    3/150 (2%)   0/100 (0%) |
|ADJUSTED (b)           |   8.3%         7.0%         4.4%         3.4%      |   1.0%         2.5%         2.4%         0.0%      |
|TERMINAL (d)           |  3/59 (5%)    1/34 (3%)    0/63 (0%)    1/43 (2%)  |  0/79 (0%)    1/40 (3%)    2/113 (2%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   571          436          455          588       |   334          729 (T)      278          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.147N     P=0.599N     P=0.337N     P=0.207N   |  P=0.299N     P=0.598      P=0.449      P=0.502N   |
|INCIDENTAL TUMOR       |  P=0.041N*    P=0.591      P=0.143N     P=0.102N   |  P=0.313N     P=0.687      P=0.321      P=0.500N   |
|LOGISTIC REGRESSION    |  P=0.067N     P=0.622      P=0.175N     P=0.122N   |  P=0.279N     P=0.743      P=0.519      P=0.417N   |
|COCHRAN-ARMITAGE       |  P=0.100N                                          |  P=0.274N                                          |
|FISHER EXACT           |               P=0.653N     P=0.242N     P=0.140N   |               P=0.557      P=0.475      P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  24
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/100 (0%)   0/50 (0%)    1/150 (1%)   3/100 (3%) |  0/100 (0%)   0/50 (0%)    1/150 (1%)   0/100 (0%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.8%         6.3%      |   0.0%         0.0%         0.9%         0.0%      |
|TERMINAL (d)           |  0/59 (0%)    0/34 (0%)    0/63 (0%)    2/43 (5%)  |  0/79 (0%)    0/40 (0%)    1/113 (1%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          597          693       |   ---          ---          729 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.017 *      (e)        P=0.572      P=0.078    |  P=0.793N       (e)        P=0.571        (e)      |
|INCIDENTAL TUMOR       |  P=0.029 *      (e)        P=0.674      P=0.093    |  P=0.793N       (e)        P=0.571        (e)      |
|LOGISTIC REGRESSION    |  P=0.026 *      (e)        P=0.611      P=0.092    |  P=0.793N       (e)        P=0.571        (e)      |
|COCHRAN-ARMITAGE       |  P=0.027 *                                         |  P=0.770N                                          |
|FISHER EXACT           |                 (e)        P=0.600      P=0.123    |                 (e)        P=0.600        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/100 (1%)   0/50 (0%)    2/150 (1%)   3/100 (3%) |  0/100 (0%)   0/50 (0%)    1/150 (1%)   1/100 (1%) |
|ADJUSTED (b)           |   1.7%         0.0%         1.8%         6.3%      |   0.0%         0.0%         0.9%         1.2%      |
|TERMINAL (d)           |  1/59 (2%)    0/34 (0%)    0/63 (0%)    2/43 (5%)  |  0/79 (0%)    0/40 (0%)    1/113 (1%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   727 (T)      ---          597          693       |   ---          ---          729 (T)      659       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.092      P=0.610N     P=0.577      P=0.211    |  P=0.318        (e)        P=0.571      P=0.498    |
|INCIDENTAL TUMOR       |  P=0.134      P=0.610N     P=0.677      P=0.236    |  P=0.383        (e)        P=0.571      P=0.598    |
|LOGISTIC REGRESSION    |  P=0.127      P=0.610N     P=0.652      P=0.239    |  P=0.339        (e)        P=0.571      P=0.512    |
|COCHRAN-ARMITAGE       |  P=0.136                                           |  P=0.336                                           |
|FISHER EXACT           |               P=0.667N     P=0.649      P=0.311    |                 (e)        P=0.600      P=0.500    |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  25
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 95/99 (96%)  47/50 (94%) 142/150 (95%) 92/100 (92%)|                                                    |
|ADJUSTED (b)           |  98.9%       100.0%       100.0%       100.0%      |                                                    |
|TERMINAL (d)           | 58/59 (98%)  34/34 (100%) 63/63 (100%) 43/43 (100%)|                                                    |
|FIRST INCIDENCE (DAYS) |   503          520          455          461       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.010 *    P=0.148N     P=0.006 **   P=0.026 *  |                                                    |
|INCIDENTAL TUMOR       |  P=0.322N     P=0.429N     P=0.593      P=0.331N   |                                                    |
|LOGISTIC REGRESSION    |  P=0.255N     P=0.431N     P=0.575N     P=0.287N   |                                                    |
|COCHRAN-ARMITAGE       |  P=0.167N                                          |                                                    |
|FISHER EXACT           |               P=0.435N     P=0.443N     P=0.191N   |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 21/72 (29%)   4/17 (24%)  20/89 (22%)  20/98 (20%) | 16/62 (26%)   4/15 (27%)   5/37 (14%)  10/96 (10%) |
|ADJUSTED (b)           |  43.6%         9.0%        38.6%        33.4%      |  32.4%        25.5%        51.5%        13.7%      |
|TERMINAL (d)           | 12/33 (36%)   0/1 (0%)     1/4 (25%)    9/42 (21%) | 12/41 (29%)   1/5 (20%)    1/2 (50%)    7/67 (10%) |
|FIRST INCIDENCE (DAYS) |   651          520          531          462       |   606          706          588          614       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.480N     P=0.414N     P=0.191      P=0.446N   |  P=0.015N*    P=0.576      P=0.534N     P=0.023N*  |
|INCIDENTAL TUMOR       |  P=0.146N     P=0.600N     P=0.532N     P=0.177N   |  P=0.005N**   P=0.539      P=0.426N     P=0.009N** |
|LOGISTIC REGRESSION    |  P=0.122N     P=0.591N     P=0.497N     P=0.136N   |  P=0.004N**   P=0.493      P=0.258N     P=0.008N** |
|COCHRAN-ARMITAGE       |  P=0.147N                                          |  P=0.008N**                                        |
|FISHER EXACT           |               P=0.446N     P=0.215N     P=0.128N   |               P=0.590      P=0.115N     P=0.011N*  |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  26
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/72 (4%)    1/17 (6%)    3/89 (3%)    2/98 (2%)  |  1/62 (2%)    2/15 (13%)   1/37 (3%)    1/96 (1%)  |
|ADJUSTED (b)           |   7.2%       100.0%         3.0%         4.8%      |   1.1%        40.0%        50.0%         1.5%      |
|TERMINAL (d)           |  2/33 (6%)    1/1 (100%)   0/4 (0%)     2/42 (5%)  |  0/41 (0%)    2/5 (40%)    1/2 (50%)    1/67 (1%)  |
|FIRST INCIDENCE (DAYS) |   632          727 (T)      517          727 (T)   |   652          729 (T)      729 (T)      729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.283N     P=0.447      P=0.494      P=0.422N   |  P=0.194N     P=0.070      P=0.601      P=0.713N   |
|INCIDENTAL TUMOR       |  P=0.214N     P=0.377      P=0.679      P=0.345N   |  P=0.180N     P=0.064      P=0.614      P=0.669N   |
|LOGISTIC REGRESSION    |  P=0.246N     P=0.552      P=0.583N     P=0.380N   |  P=0.193N     P=0.069      P=0.597      P=0.663N   |
|COCHRAN-ARMITAGE       |  P=0.260N                                          |  P=0.227N                                          |
|FISHER EXACT           |               P=0.579      P=0.554N     P=0.357N   |               P=0.095      P=0.610      P=0.632N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 23/72 (32%)   5/17 (29%)  23/89 (26%)  21/98 (21%) | 17/62 (27%)   6/15 (40%)   6/37 (16%)  11/96 (11%) |
|ADJUSTED (b)           |  46.9%       100.0%        40.4%        35.5%      |  33.2%        62.8%       100.0%        15.2%      |
|TERMINAL (d)           | 13/33 (39%)   1/1 (100%)   1/4 (25%)   10/42 (24%) | 12/41 (29%)   3/5 (60%)    2/2 (100%)   8/67 (12%) |
|FIRST INCIDENCE (DAYS) |   632          520          517          462       |   606          706          588          614       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.363N     P=0.547N     P=0.150      P=0.371N   |  P=0.006N**   P=0.246      P=0.620N     P=0.024N*  |
|INCIDENTAL TUMOR       |  P=0.075N     P=0.482      P=0.552N     P=0.116N   |  P=0.002N**   P=0.188      P=0.524N     P=0.009N** |
|LOGISTIC REGRESSION    |  P=0.064N     P=0.533      P=0.509N     P=0.092N   |  P=0.002N**   P=0.160      P=0.331N     P=0.008N** |
|COCHRAN-ARMITAGE       |  P=0.080N                                          |  P=0.003N**                                        |
|FISHER EXACT           |               P=0.544N     P=0.249N     P=0.086N   |               P=0.256      P=0.151N     P=0.010N** |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  27
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/72 (1%)    0/17 (0%)    4/89 (4%)    0/98 (0%)  |  0/62 (0%)    0/15 (0%)    0/37 (0%)    0/96 (0%)  |
|ADJUSTED (b)           |   1.6%         0.0%        27.5%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/33 (0%)    0/1 (0%)     1/4 (25%)    0/42 (0%)  |  0/41 (0%)    0/5 (0%)     0/2 (0%)     0/67 (0%)  |
|FIRST INCIDENCE (DAYS) |   710          ---          626          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.370N     P=0.609N     P=0.127      P=0.562N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.246N     P=0.682N     P=0.243      P=0.470N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.219N     P=0.866N     P=0.138      P=0.447N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.231N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.809N     P=0.257      P=0.424N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/72 (3%)    0/17 (0%)    1/89 (1%)    0/98 (0%)  |  0/62 (0%)    0/15 (0%)    0/37 (0%)    0/96 (0%)  |
|ADJUSTED (b)           |   4.1%         0.0%        25.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/33 (3%)    0/1 (0%)     1/4 (25%)    0/42 (0%)  |  0/41 (0%)    0/5 (0%)     0/2 (0%)     0/67 (0%)  |
|FIRST INCIDENCE (DAYS) |   577          ---          727 (T)      ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.152N     P=0.604N     P=0.678      P=0.216N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.119N     P=0.682N     P=0.762      P=0.135N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.148N     P=0.557N     P=0.480N     P=0.172N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.150N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.653N     P=0.421N     P=0.178N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  28
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/72 (4%)    0/17 (0%)    5/89 (6%)    0/98 (0%)  |  0/62 (0%)    0/15 (0%)    0/37 (0%)    0/96 (0%)  |
|ADJUSTED (b)           |   5.6%         0.0%        51.6%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/33 (3%)    0/1 (0%)     2/4 (50%)    0/42 (0%)  |  0/41 (0%)    0/5 (0%)     0/2 (0%)     0/67 (0%)  |
|FIRST INCIDENCE (DAYS) |   577          ---          626          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.112N     P=0.368N     P=0.129      P=0.128N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.056N     P=0.460N     P=0.260      P=0.063N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.062N     P=0.457N     P=0.330      P=0.073N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.065N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.525N     P=0.483      P=0.074N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Tongue                                                                                                                           |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/100 (0%)   0/50 (0%)    1/150 (1%)   0/100 (0%) |  0/100 (0%)   0/50 (0%)    2/150 (1%)   0/100 (0%) |
|ADJUSTED (b)           |   0.0%         0.0%         1.2%         0.0%      |   0.0%         0.0%         1.5%         0.0%      |
|TERMINAL (d)           |  0/59 (0%)    0/34 (0%)    0/63 (0%)    0/43 (0%)  |  0/79 (0%)    0/40 (0%)    0/113 (0%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          693          ---       |   ---          ---          429          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.798N       (e)        P=0.538        (e)      |  P=0.677N       (e)        P=0.334        (e)      |
|INCIDENTAL TUMOR       |  P=0.760N       (e)        P=0.630        (e)      |  P=0.567N       (e)        P=0.377        (e)      |
|LOGISTIC REGRESSION    |  P=0.777N       (e)        P=0.572        (e)      |  P=0.683N       (e)        P=0.359        (e)      |
|COCHRAN-ARMITAGE       |  P=0.770N                                          |  P=0.664N                                          |
|FISHER EXACT           |                 (e)        P=0.600        (e)      |                 (e)        P=0.359        (e)      |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  29
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Tongue                                                                                                                           |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/100 (0%)   0/50 (0%)    1/150 (1%)   0/100 (0%) |  1/100 (1%)   1/50 (2%)    2/150 (1%)   0/100 (0%) |
|ADJUSTED (b)           |   0.0%         0.0%         1.2%         0.0%      |   1.3%         2.5%         1.5%         0.0%      |
|TERMINAL (d)           |  0/59 (0%)    0/34 (0%)    0/63 (0%)    0/43 (0%)  |  1/79 (1%)    1/40 (3%)    0/113 (0%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          693          ---       |   729 (T)      729 (T)      429          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.798N       (e)        P=0.538        (e)      |  P=0.300N     P=0.602      P=0.634      P=0.530N   |
|INCIDENTAL TUMOR       |  P=0.760N       (e)        P=0.630        (e)      |  P=0.240N     P=0.602      P=0.673      P=0.530N   |
|LOGISTIC REGRESSION    |  P=0.777N       (e)        P=0.572        (e)      |  P=0.271N     P=0.602      P=0.667      P=0.530N   |
|COCHRAN-ARMITAGE       |  P=0.770N                                          |  P=0.275N                                          |
|FISHER EXACT           |                 (e)        P=0.600        (e)      |               P=0.557      P=0.649      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  3/100 (3%)   2/50 (4%)    0/150 (0%)   1/100 (1%) |
|ADJUSTED (b)           |                                                    |   3.6%         4.7%         0.0%         1.5%      |
|TERMINAL (d)           |                                                    |  2/79 (3%)    1/40 (3%)    0/113 (0%)   1/68 (1%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   606          684          ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.223N     P=0.574      P=0.067N     P=0.351N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.180N     P=0.559      P=0.055N     P=0.311N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.194N     P=0.568      P=0.060N     P=0.304N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.194N                                          |
|FISHER EXACT           |                                                    |               P=0.541      P=0.063N     P=0.311N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  30
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    | 11/100 (11%)  2/50 (4%)   13/150 (9%)  11/100 (11%)|
|ADJUSTED (b)           |                                                    |  13.9%         5.0%        11.3%        16.2%      |
|TERMINAL (d)           |                                                    | 11/79 (14%)   2/40 (5%)   12/113 (11%) 11/68 (16%) |
|FIRST INCIDENCE (DAYS) |                                                    |   729 (T)      729 (T)      646          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.216      P=0.123N     P=0.391N     P=0.441    |
|INCIDENTAL TUMOR       |                                                    |  P=0.230      P=0.123N     P=0.386N     P=0.441    |
|LOGISTIC REGRESSION    |                                                    |  P=0.260      P=0.123N     P=0.360N     P=0.441    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.347                                           |
|FISHER EXACT           |                                                    |               P=0.127N     P=0.343N     P=0.589N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    | 11/100 (11%)  2/50 (4%)   14/150 (9%)  12/100 (12%)|
|ADJUSTED (b)           |                                                    |  13.9%         5.0%        12.2%        17.2%      |
|TERMINAL (d)           |                                                    | 11/79 (14%)   2/40 (5%)   13/113 (12%) 11/68 (16%) |
|FIRST INCIDENCE (DAYS) |                                                    |   729 (T)      729 (T)      646          674       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.151      P=0.123N     P=0.463N     P=0.354    |
|INCIDENTAL TUMOR       |                                                    |  P=0.172      P=0.123N     P=0.458N     P=0.376    |
|LOGISTIC REGRESSION    |                                                    |  P=0.196      P=0.123N     P=0.430N     P=0.414    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.263                                           |
|FISHER EXACT           |                                                    |               P=0.127N     P=0.411N     P=0.500    |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  31
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/100 (1%)   0/50 (0%)    0/150 (0%)   0/100 (0%) |  0/100 (0%)   0/50 (0%)    2/150 (1%)   0/100 (0%) |
|ADJUSTED (b)           |   1.2%         0.0%         0.0%         0.0%      |   0.0%         0.0%         1.6%         0.0%      |
|TERMINAL (d)           |  0/59 (0%)    0/34 (0%)    0/63 (0%)    0/43 (0%)  |  0/79 (0%)    0/40 (0%)    0/113 (0%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   651          ---          ---          ---       |   ---          ---          610          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.466N     P=0.633N     P=0.443N     P=0.531N   |  P=0.683N       (e)        P=0.329        (e)      |
|INCIDENTAL TUMOR       |  P=0.422N     P=0.690N     P=0.370N     P=0.478N   |  P=0.561N       (e)        P=0.377        (e)      |
|LOGISTIC REGRESSION    |  P=0.432N     P=0.646N     P=0.403N     P=0.484N   |  P=0.660N       (e)        P=0.340        (e)      |
|COCHRAN-ARMITAGE       |  P=0.443N                                          |  P=0.664N                                          |
|FISHER EXACT           |               P=0.667N     P=0.400N     P=0.500N   |                 (e)        P=0.359        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/100 (0%)   0/50 (0%)    1/150 (1%)   2/100 (2%) |  0/100 (0%)   0/50 (0%)    0/150 (0%)   0/100 (0%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.9%         4.4%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/59 (0%)    0/34 (0%)    0/63 (0%)    1/43 (2%)  |  0/79 (0%)    0/40 (0%)    0/113 (0%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          639          718       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.073        (e)        P=0.560      P=0.180    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.123        (e)        P=0.674      P=0.216    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.092        (e)        P=0.602      P=0.188    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.099                                           |    (e)                                             |
|FISHER EXACT           |                 (e)        P=0.600      P=0.249    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  32
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear,                                                                              |
|     or Undifferentiated                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 57/100 (57%) 32/50 (64%) 111/150 (74%) 68/100 (68%)| 27/100 (27%) 20/50 (40%)  66/150 (44%) 48/100 (48%)|
|ADJUSTED (b)           |  68.4%        71.0%        84.5%        77.5%      |  31.4%        43.4%        48.7%        51.5%      |
|TERMINAL (d)           | 33/59 (56%)  21/34 (62%)  44/63 (70%)  25/43 (58%) | 21/79 (27%)  14/40 (35%)  45/113 (40%) 24/68 (35%) |
|FIRST INCIDENCE (DAYS) |   505          520          397          461       |   515          592          485          491       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.005 **   P=0.544N     P<0.001 **   P=0.006 ** |  P=0.002 **   P=0.102      P=0.005 **   P=0.001 ** |
|INCIDENTAL TUMOR       |  P=0.178      P=0.228      P=0.005 **   P=0.101    |  P=0.017 *    P=0.070      P=0.006 **   P=0.005 ** |
|LOGISTIC REGRESSION    |  P=0.181      P=0.296      P=0.003 **   P=0.094    |  P=0.014 *    P=0.076      P=0.004 **   P=0.003 ** |
|COCHRAN-ARMITAGE       |  P=0.129                                           |  P=0.006 **                                        |
|FISHER EXACT           |               P=0.260      P=0.004 **   P=0.072    |               P=0.077      P=0.005 **   P=0.002 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/100 (2%)   0/50 (0%)    1/150 (1%)   0/100 (0%) |  0/100 (0%)   1/50 (2%)    0/150 (0%)   1/100 (1%) |
|ADJUSTED (b)           |   2.1%         0.0%         1.4%         0.0%      |   0.0%         2.5%         0.0%         1.5%      |
|TERMINAL (d)           |  0/59 (0%)    0/34 (0%)    0/63 (0%)    0/43 (0%)  |  0/79 (0%)    1/40 (3%)    0/113 (0%)   1/68 (1%)  |
|FIRST INCIDENCE (DAYS) |   503          ---          710          ---       |   ---          729 (T)      ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.248N     P=0.402N     P=0.404N     P=0.244N   |  P=0.473      P=0.364        (e)        P=0.470    |
|INCIDENTAL TUMOR       |  P=0.152N     P=0.435N     P=0.231N     P=0.124N   |  P=0.473      P=0.364        (e)        P=0.470    |
|LOGISTIC REGRESSION    |  P=0.199N     P=0.416N     P=0.310N     P=0.209N   |  P=0.473      P=0.364        (e)        P=0.470    |
|COCHRAN-ARMITAGE       |  P=0.223N                                          |  P=0.506                                           |
|FISHER EXACT           |               P=0.443N     P=0.351N     P=0.249N   |               P=0.333        (e)        P=0.500    |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  33
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/100 (2%)   0/50 (0%)    1/150 (1%)   0/100 (0%) |  0/100 (0%)   1/50 (2%)    0/150 (0%)   1/100 (1%) |
|ADJUSTED (b)           |   2.1%         0.0%         1.4%         0.0%      |   0.0%         2.5%         0.0%         1.5%      |
|TERMINAL (d)           |  0/59 (0%)    0/34 (0%)    0/63 (0%)    0/43 (0%)  |  0/79 (0%)    1/40 (3%)    0/113 (0%)   1/68 (1%)  |
|FIRST INCIDENCE (DAYS) |   503          ---          710          ---       |   ---          729 (T)      ---          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.248N     P=0.402N     P=0.404N     P=0.244N   |  P=0.473      P=0.364        (e)        P=0.470    |
|INCIDENTAL TUMOR       |  P=0.152N     P=0.435N     P=0.231N     P=0.124N   |  P=0.473      P=0.364        (e)        P=0.470    |
|LOGISTIC REGRESSION    |  P=0.199N     P=0.416N     P=0.310N     P=0.209N   |  P=0.473      P=0.364        (e)        P=0.470    |
|COCHRAN-ARMITAGE       |  P=0.223N                                          |  P=0.506                                           |
|FISHER EXACT           |               P=0.443N     P=0.351N     P=0.249N   |               P=0.333        (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma Benign, Malignant, NOS                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/100 (7%)   0/50 (0%)    6/150 (4%)   1/100 (1%) |  1/100 (1%)   0/50 (0%)    0/150 (0%)   0/100 (0%) |
|ADJUSTED (b)           |   9.8%         0.0%         6.5%         1.2%      |   1.2%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  4/59 (7%)    0/34 (0%)    0/63 (0%)    0/43 (0%)  |  0/79 (0%)    0/40 (0%)    0/113 (0%)   0/68 (0%)  |
|FIRST INCIDENCE (DAYS) |   503          ---          594          604       |   681          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.115N     P=0.058N     P=0.361N     P=0.064N   |  P=0.450N     P=0.627N     P=0.421N     P=0.507N   |
|INCIDENTAL TUMOR       |  P=0.040N*    P=0.052N     P=0.154N     P=0.028N*  |  P=0.367N     P=0.657N     P=0.402N     P=0.402N   |
|LOGISTIC REGRESSION    |  P=0.056N     P=0.069N     P=0.199N     P=0.027N*  |  P=0.440N     P=0.632N     P=0.415N     P=0.493N   |
|COCHRAN-ARMITAGE       |  P=0.066N                                          |  P=0.443N                                          |
|FISHER EXACT           |               P=0.054N     P=0.223N     P=0.032N*  |               P=0.667N     P=0.400N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  34
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 97/100 (97%) 48/50 (96%) 145/150 (97%) 98/100 (98%)| 64/100 (64%) 25/50 (50%) 108/150 (72%) 87/100 (87%)|
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  70.1%        54.2%        81.1%        97.7%      |
|TERMINAL (d)           | 59/59 (100%) 34/34 (100%) 63/63 (100%) 43/43 (100%)| 52/79 (66%)  19/40 (48%)  88/113 (78%) 66/68 (97%) |
|FIRST INCIDENCE (DAYS) |   503          520          455          450       |   523          487          565          312       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.003 **   P=0.146N     P=0.006 **   P=0.009 ** |  P<0.001 **   P=0.084N     P=0.071      P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.197      P=0.557N     P=0.456      P=0.336    |  P<0.001 **   P=0.080N     P=0.092      P<0.001 ** |
|LOGISTIC REGRESSION    |  P=0.255      P=0.597N     P=0.577      P=0.427    |  P<0.001 **   P=0.071N     P=0.089      P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.364                                           |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.541N     P=0.595N     P=0.500    |               P=0.071N     P=0.116      P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 77/100 (77%) 39/50 (78%) 125/150 (83%) 89/100 (89%)| 36/100 (36%) 25/50 (50%)  79/150 (53%) 63/100 (63%)|
|ADJUSTED (b)           |  80.9%        79.6%        88.4%        92.6%      |  39.6%        53.2%        55.5%        66.0%      |
|TERMINAL (d)           | 41/59 (69%)  24/34 (71%)  47/63 (75%)  36/43 (84%) | 25/79 (32%)  18/40 (45%)  51/113 (45%) 36/68 (53%) |
|FIRST INCIDENCE (DAYS) |   367          436          397          461       |   334          592          278          312       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.307N     P=0.006 **   P=0.002 ** |  P<0.001 **   P=0.110      P=0.010 *    P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.041 *    P=0.433      P=0.290      P=0.052    |  P=0.001 **   P=0.069      P=0.009 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P=0.036 *    P=0.494      P=0.187      P=0.046 *  |  P<0.001 **   P=0.071      P=0.007 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.013 *                                         |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.532      P=0.140      P=0.019 *  |               P=0.071      P=0.007 **   P<0.001 ** |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05077 TEST: 01                                                 PAGE  35
                  STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
 
                                                 MALE TERMINAL SACRIFICE AT 104 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3 PPM        10 PPM       30 PPM    |   0 PPM        3 PPM        10 PPM       30 PPM    |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |100/100 (100% 50/50 (100%)150/150 (100%100/100 (100%) 77/100 (77%) 35/50 (70%) 132/150 (88%) 97/100 (97%)|
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  78.5%        71.4%        88.6%        99.0%      |
|TERMINAL (d)           | 59/59 (100%) 34/34 (100%) 63/63 (100%) 43/43 (100%)| 58/79 (73%)  26/40 (65%)  96/113 (85%) 67/68 (99%) |
|FIRST INCIDENCE (DAYS) |   367          436          397          450       |   334          487          278          312       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.005 **   P=0.179N     P=0.006 **   P=0.013 *  |  P<0.001 **   P=0.259N     P=0.037 *    P<0.001 ** |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P<0.001 **   P=0.251N     P=0.021 *    P<0.001 ** |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P<0.001 **   P=0.232N     P=0.018 *    P<0.001 ** |
|COCHRAN-ARMITAGE       |    (e)                                             |  P<0.001 **                                        |
|FISHER EXACT           |               P=1.000N     P=1.000N     P=1.000N   |               P=0.231N     P=0.017 *    P<0.001 ** |
|=================================================================================================================================|
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).

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