TDMS Study 05077-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/10/94
EXP: 05077 FIREMASTER FF-1 POLYBROMINATED BIPHENYL TIME: 05:43:26
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 53634B
CONT: NO1-ES-82151 CAS: 67774327
PATHOLOGIST: R. PERSING S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
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REMOVAL DATE RANGE:
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/10/94
EXP: 05077 FIREMASTER FF-1 POLYBROMINATED BIPHENYL TIME: 05:43:26
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 53634B
CONT: NO1-ES-82151 CAS: 67774327
PATHOLOGIST: R. PERSING S. EUSTIS
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM 0-0 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 505 507 555 571 576 651 651 657 671 675 |
| 676 686 693 694 694 699 702 706 710 713 |
| 714 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0 PPM 10-0 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 367 503 542 577 580 584 584 593 601 632 |
| 646 651 665 668 689 689 691 702 714 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3 PPM 1-1 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 436 487 520 581 582 616 645 654 676 676 |
| 679 683 702 717 721 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 10 PPM 0-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 27 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 503 560 563 568 573 582 597 609 656 661 |
| 669 674 678 679 683 685 686 693 695 700 |
| 700 707 714 716 717 721 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM 3-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 455 484 491 492 510 517 529 549 582 583 |
| 618 619 626 626 645 657 668 673 676 676 |
| 685 689 691 693 693 695 696 701 703 710 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM 10-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 397 522 531 531 546 547 577 583 594 619 |
| 623 626 630 639 644 654 657 661 666 667 |
| 674 679 689 691 694 699 706 706 710 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 30 PPM 0-10 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 493 517 536 588 604 605 619 623 631 643 |
| 643 656 659 661 661 682 682 683 692 693 |
| 699 700 701 707 713 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 PPM 10-10 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 31 CENSORED DEATHS 0 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 450 461 462 515 534 572 575 581 581 596 |
| 603 605 605 637 642 643 644 651 657 668 |
| 674 679 684 686 695 695 696 696 708 718 |
| 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 727 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 727 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM 0-0| 100.0 100.0 100.0 100.0 100.0 100.0 96.0 90.0 84.0 58.0 |
| | |
| | |
|0 | 100.0 100.0 100.0 100.0 98.0 98.0 94.0 82.0 74.0 60.0 |
|PPM 10-0 | |
| | |
|3 PPM 1-1| 100.0 100.0 100.0 100.0 100.0 98.0 94.0 90.0 84.0 68.0 |
| | |
| | |
|10 | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 86.0 80.0 46.0 |
|PPM 0-3 | |
| | |
|10 | 100.0 100.0 100.0 100.0 100.0 96.0 86.0 80.0 68.0 40.0 |
|PPM 3-3 | |
| | |
|10 | 100.0 100.0 100.0 100.0 98.0 98.0 92.0 82.0 64.0 40.0 |
|PPM 10-3 | |
| | |
|30 | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 88.0 70.0 48.0 |
|PPM 0-10 | |
| | |
|30 | 100.0 100.0 100.0 100.0 100.0 94.0 90.0 74.0 62.0 38.0 |
|PPM 10-10| |
| | |
==================================================================================
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 727 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 0-0 0 3 PPM 1-1 10 10 10 30 30 |
| PPM 10-0 PPM 0-3 PPM 3-3 PPM 10-3 PPM 0-10 PPM 10-|0
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 58.0% 60.0% 68.0% 46.0% 40.0% 40.0% 48.0% 38.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.010 ----- P=0.424N P=0.333 P=0.049 P=0.055 P=0.329 P=0.033 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 652.7 619.7 631.0 656.0 621.1 629.5 646.8 623.8 |
|NATURAL DEATHS (C) | (14.7) (18.9) (21.9) (11.9) (14.7) (13.5) (11.9) (13.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 695.8 684.1 696.3 688.6 663.4 668.5 685.3 663.0 |
|(STANDARD ERROR) | ( 8.0) (10.6) ( 9.4) ( 8.1) (11.5) (10.5) ( 8.4) (11.1) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM 0-0 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 334 523 544 579 656 656 678 681 681 687 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0 PPM 10-0 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 515 579 591 606 635 635 652 666 707 710 |
| 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3 PPM 1-1 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 187 487 592 615 639 684 706 719 720 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 10 PPM 0-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 485 502 565 576 588 615 661 680 691 705 |
| 709 720 721 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM 3-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 429 507 574 591 625 639 646 707 711 718 |
| 720 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM 10-3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 278 511 529 608 610 621 625 652 653 685 |
| 711 714 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 30 PPM 0-10 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 491 516 537 579 593 614 632 642 659 659 |
| 674 684 688 704 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 PPM 10-10 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 312 543 562 577 599 633 674 682 682 684 |
| 695 704 706 707 710 716 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM 0-0| 100.0 100.0 100.0 98.0 98.0 98.0 94.0 92.0 88.0 80.0 |
| | |
| | |
|0 | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 94.0 86.0 78.0 |
|PPM 10-0 | |
| | |
|3 PPM 1-1| 100.0 100.0 98.0 98.0 98.0 98.0 96.0 94.0 90.0 80.0 |
| | |
| | |
|10 | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 90.0 86.0 72.0 |
|PPM 0-3 | |
| | |
|10 | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 92.0 86.0 78.0 |
|PPM 3-3 | |
| | |
|10 | 100.0 100.0 100.0 98.0 98.0 98.0 94.0 94.0 82.0 76.0 |
|PPM 10-3 | |
| | |
|30 | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 90.0 80.0 70.0 |
|PPM 0-10 | |
| | |
|30 | 100.0 100.0 100.0 98.0 98.0 98.0 96.0 90.0 88.0 66.0 |
|PPM 10-10| |
| | |
==================================================================================
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 0-0 0 3 PPM 1-1 10 10 10 30 30 |
| PPM 10-0 PPM 0-3 PPM 3-3 PPM 10-3 PPM 0-10 PPM 10-|0
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 80.0% 78.0% 80.0% 72.0% 78.0% 76.0% 70.0% 66.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.059 ----- P=1.000N P=0.524 P=1.000 P=0.772 P=0.356 P=0.224 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 601.9 638.2 607.6 638.7 624.3 599.8 626.7 641.8 |
|NATURAL DEATHS (C) | (35.5) (19.1) (52.4) (22.2) (28.4) (34.4) (18.3) (24.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 703.6 709.0 704.7 703.7 706.0 698.0 698.3 699.3 |
|(STANDARD ERROR) | ( 9.9) ( 6.7) (12.2) ( 8.4) ( 8.6) (11.2) ( 8.6) (10.2) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM 0-0 = 1
0 PPM 10-0 = 2
3 PPM 1-1 = 3
10 PPM 0-3 = 4
10 PPM 3-3 = 5
10 PPM 10-3 = 6
30 PPM 0-10 = 7
30 PPM 10-10 = 8
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
104 +
|
| 1 2 6 3 5 741
| 2 6 3 58 372 7 6 4
96 + 35217 3672 14
| 8 8 3 72 14127
| 5 58 686 113 7
| 55 866 412 3 1
88 + 5 5 6 864 4737 3
| 5 5 62 244 11
P | 5 5 224 7 7 1 13
E | 8 62 6 27 4 411
R 80 + 5 88 5 2 2 44
C | 66 7 7 411
E | 55 27 2 11 3
N | 8 686 22 113 3
T 72 + 5885 2442
| 655 7 7
S | 5 5 11 33
U | 886 65542 2
R 64 + 88 66 74411
V | 8 8 22
I | 65577 22
V | 55441 1
A 56 + 686744
L | 44
| 86677
| 55 7 7
48 + 66 44
| 55 4
| 866
| 5586
40 + 585
| 8
|
|
32 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 54 obs hidden.
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM 0-0 = 1
0 PPM 10-0 = 2
3 PPM 1-1 = 3
10 PPM 0-3 = 4
10 PPM 3-3 = 5
10 PPM 10-3 = 6
30 PPM 0-10 = 7
30 PPM 10-10 = 8
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 3 6 8 1 5 47 2
|
| 3 6 8 1 5 37452 1 8 2
|
96 + 3 457 1671 452 2
|
| 671 451 2 23
|
92 + 14 5823 523 1
|
P | 4 78 46583 3
E |
R 88 + 4662551 4 13 3
C |
E | 67752 4211 3 3
N |
T 84 + 7 72 44 25
|
S | 6 11 2233
U |
R 80 + 7 761842 2 1
V |
I | 77 88442 2
V |
A 76 + 77 6 6
L |
| 7 7 44
|
72 + 78 4 4
|
| 887 7
|
68 + 88
|
| 8 8
|
64 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 55 obs hidden.
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