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TDMS Study 05077-01 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/10/94   
EXP: 05077         FIREMASTER FF-1 POLYBROMINATED BIPHENYL     TIME: 05:43:26   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 53634B   
CONT: NO1-ES-82151                                             CAS: 67774327    
PATHOLOGIST: R. PERSING                      S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/10/94  
EXP: 05077         FIREMASTER FF-1 POLYBROMINATED BIPHENYL     TIME: 05:43:26  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 53634B  
CONT: NO1-ES-82151                                             CAS: 67774327   
PATHOLOGIST: R. PERSING                      S. EUSTIS                         

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 727 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM   0-0                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      505   507   555   571   576   651   651   657   671   675                 |
 |      676   686   693   694   694   699   702   706   710   713                 |
 |      714                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0 PPM   10-0                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 20     CENSORED DEATHS 0    TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      367   503   542   577   580   584   584   593   601   632                 |
 |      646   651   665   668   689   689   691   702   714   716                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 3 PPM   1-1                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      436   487   520   581   582   616   645   654   676   676                 |
 |      679   683   702   717   721   721                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 727 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 10 PPM   0-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 27     CENSORED DEATHS 0    TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      503   560   563   568   573   582   597   609   656   661                 |
 |      669   674   678   679   683   685   686   693   695   700                 |
 |      700   707   714   716   717   721   722                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 10 PPM   3-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 30     CENSORED DEATHS 0    TERMINAL 20        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      455   484   491   492   510   517   529   549   582   583                 |
 |      618   619   626   626   645   657   668   673   676   676                 |
 |      685   689   691   693   693   695   696   701   703   710                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 10 PPM   10-3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 30     CENSORED DEATHS 0    TERMINAL 20        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      397   522   531   531   546   547   577   583   594   619                 |
 |      623   626   630   639   644   654   657   661   666   667                 |
 |      674   679   689   691   694   699   706   706   710   722                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 727 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 30 PPM   0-10                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      493   517   536   588   604   605   619   623   631   643                 |
 |      643   656   659   661   661   682   682   683   692   693                 |
 |      699   700   701   707   713   725                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 30 PPM   10-10                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 31     CENSORED DEATHS 0    TERMINAL 19        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      450   461   462   515   534   572   575   581   581   596                 |
 |      603   605   605   637   642   643   644   651   657   668                 |
 |      674   679   684   686   695   695   696   696   708   718                 |
 |      726                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 727 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   727 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM   0-0|   100.0 100.0 100.0 100.0 100.0 100.0  96.0  90.0  84.0  58.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0          |   100.0 100.0 100.0 100.0  98.0  98.0  94.0  82.0  74.0  60.0      |
 |PPM   10-0 |                                                                    |
 |           |                                                                    |
 |3 PPM   1-1|   100.0 100.0 100.0 100.0 100.0  98.0  94.0  90.0  84.0  68.0      |
 |           |                                                                    |
 |           |                                                                    |
 |10         |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  86.0  80.0  46.0      |
 |PPM   0-3  |                                                                    |
 |           |                                                                    |
 |10         |   100.0 100.0 100.0 100.0 100.0  96.0  86.0  80.0  68.0  40.0      |
 |PPM   3-3  |                                                                    |
 |           |                                                                    |
 |10         |   100.0 100.0 100.0 100.0  98.0  98.0  92.0  82.0  64.0  40.0      |
 |PPM   10-3 |                                                                    |
 |           |                                                                    |
 |30         |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  88.0  70.0  48.0      |
 |PPM   0-10 |                                                                    |
 |           |                                                                    |
 |30         |   100.0 100.0 100.0 100.0 100.0  94.0  90.0  74.0  62.0  38.0      |
 |PPM   10-10|                                                                    |
 |           |                                                                    |
 ==================================================================================

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 727 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0 PPM   0-0 0           3 PPM   1-1 10          10          10          30          30       |
 |                                            PPM   10-0              PPM   0-3   PPM   3-3   PPM   10-3  PPM   0-10  PPM   10-|0
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       58.0%       60.0%       68.0%       46.0%       40.0%       40.0%       48.0%       38.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.010      -----      P=0.424N    P=0.333     P=0.049     P=0.055     P=0.329     P=0.033  |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       652.7       619.7       631.0       656.0       621.1       629.5       646.8       623.8    |
 |NATURAL DEATHS (C)      |       (14.7)      (18.9)      (21.9)      (11.9)      (14.7)      (13.5)      (11.9)      (13.9)   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       695.8       684.1       696.3       688.6       663.4       668.5       685.3       663.0    |
 |(STANDARD ERROR)        |       ( 8.0)      (10.6)      ( 9.4)      ( 8.1)      (11.5)      (10.5)      ( 8.4)      (11.1)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM   0-0                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 10     CENSORED DEATHS 0    TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      334   523   544   579   656   656   678   681   681   687                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0 PPM   10-0                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 11     CENSORED DEATHS 0    TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      515   579   591   606   635   635   652   666   707   710                 |
 |      724                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 3 PPM   1-1                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 10     CENSORED DEATHS 0    TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      187   487   592   615   639   684   706   719   720   727                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 10 PPM   0-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      485   502   565   576   588   615   661   680   691   705                 |
 |      709   720   721   724                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 10 PPM   3-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 11     CENSORED DEATHS 0    TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      429   507   574   591   625   639   646   707   711   718                 |
 |      720                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 10 PPM   10-3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 0    TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      278   511   529   608   610   621   625   652   653   685                 |
 |      711   714                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 30 PPM   0-10                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      491   516   537   579   593   614   632   642   659   659                 |
 |      674   684   688   704   728                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 30 PPM   10-10                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      312   543   562   577   599   633   674   682   682   684                 |
 |      695   704   706   707   710   716   724                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM   0-0|   100.0 100.0 100.0  98.0  98.0  98.0  94.0  92.0  88.0  80.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0          |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  94.0  86.0  78.0      |
 |PPM   10-0 |                                                                    |
 |           |                                                                    |
 |3 PPM   1-1|   100.0 100.0  98.0  98.0  98.0  98.0  96.0  94.0  90.0  80.0      |
 |           |                                                                    |
 |           |                                                                    |
 |10         |   100.0 100.0 100.0 100.0 100.0  98.0  96.0  90.0  86.0  72.0      |
 |PPM   0-3  |                                                                    |
 |           |                                                                    |
 |10         |   100.0 100.0 100.0 100.0 100.0  98.0  96.0  92.0  86.0  78.0      |
 |PPM   3-3  |                                                                    |
 |           |                                                                    |
 |10         |   100.0 100.0 100.0  98.0  98.0  98.0  94.0  94.0  82.0  76.0      |
 |PPM   10-3 |                                                                    |
 |           |                                                                    |
 |30         |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  90.0  80.0  70.0      |
 |PPM   0-10 |                                                                    |
 |           |                                                                    |
 |30         |   100.0 100.0 100.0  98.0  98.0  98.0  96.0  90.0  88.0  66.0      |
 |PPM   10-10|                                                                    |
 |           |                                                                    |
 ==================================================================================

                      FIREMASTER FF-1 POLYBROMINATED BIPHENYL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0 PPM   0-0 0           3 PPM   1-1 10          10          10          30          30       |
 |                                            PPM   10-0              PPM   0-3   PPM   3-3   PPM   10-3  PPM   0-10  PPM   10-|0
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       80.0%       78.0%       80.0%       72.0%       78.0%       76.0%       70.0%       66.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.059      -----      P=1.000N    P=0.524     P=1.000     P=0.772     P=0.356     P=0.224  |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       601.9       638.2       607.6       638.7       624.3       599.8       626.7       641.8    |
 |NATURAL DEATHS (C)      |       (35.5)      (19.1)      (52.4)      (22.2)      (28.4)      (34.4)      (18.3)      (24.9)   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       703.6       709.0       704.7       703.7       706.0       698.0       698.3       699.3    |
 |(STANDARD ERROR)        |       ( 9.9)      ( 6.7)      (12.2)      ( 8.4)      ( 8.6)      (11.2)      ( 8.6)      (10.2)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM   0-0      = 1
                                                        0 PPM   10-0     = 2
                                                        3 PPM   1-1      = 3
                                                        10 PPM   0-3     = 4
                                                        10 PPM   3-3     = 5
                                                        10 PPM   10-3    = 6
                                                        30 PPM   0-10    = 7
                                                        30 PPM   10-10   = 8

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  104 +
      |
      | 1                                                         2    6     3  5     741
      |                                                           2    6     3  58   372 7 6    4
   96 +                                                                              35217 3672 14
      |                                                                          8       8 3 72 14127
      |                                                                               5 58  686   113   7
      |                                                                                 55   866  412    3    1
   88 +                                                                                  5  5  6  864  4737   3
      |                                                                                     5  5   62 244     11
P     |                                                                                        5    5 224 7 7  1  13
E     |                                                                                            8  62  6 27 4 411
R  80 +                                                                                             5  88 5 2 2  44
C     |                                                                                                   66 7 7  411
E     |                                                                                                   55  27 2  11 3
N     |                                                                                                 8  686   22  113 3
T  72 +                                                                                                    5885   2442
      |                                                                                                      655 7  7
S     |                                                                                                        5  5   11 33
U     |                                                                                                      886 65542 2
R  64 +                                                                                                       88 66 74411
V     |                                                                                                        8  8     22
I     |                                                                                                           65577  22
V     |                                                                                                             55441 1
A  56 +                                                                                                            686744
L     |                                                                                                                 44
      |                                                                                                             86677
      |                                                                                                              55 7 7
   48 +                                                                                                               66 44
      |                                                                                                               55  4
      |                                                                                                               866
      |                                                                                                                5586
   40 +                                                                                                                 585
      |                                                                                                                   8
      |
      |
   32 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 54 obs hidden.

                                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM   0-0      = 1
                                                        0 PPM   10-0     = 2
                                                        3 PPM   1-1      = 3
                                                        10 PPM   0-3     = 4
                                                        10 PPM   3-3     = 5
                                                        10 PPM   10-3    = 6
                                                        30 PPM   0-10    = 7
                                                        30 PPM   10-10   = 8

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1                             3             6     8  1              5        47  2
      |
      |                               3             6     8  1              5        37452 1  8    2
      |
   96 +                                                                              3 457 1671  452  2
      |
      |                                                                                     671  451  2 23
      |
   92 +                                                                                            14 5823 523 1
      |
P     |                                                                                             4 78 46583      3
E     |
R  88 +                                                                                                  4662551 4 13  3
C     |
E     |                                                                                                    67752 4211  3 3
N     |
T  84 +                                                                                                      7   72 44 25
      |
S     |                                                                                                        6    11 2233
U     |
R  80 +                                                                                                          7 761842 2 1
V     |
I     |                                                                                                            77 88442 2
V     |
A  76 +                                                                                                             77  6   6
L     |
      |                                                                                                              7 7 44
      |
   72 +                                                                                                                78 4 4
      |
      |                                                                                                                 887 7
      |
   68 +                                                                                                                  88
      |
      |                                                                                                                   8 8
      |
   64 +
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        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

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