National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2489

TDMS Study 05079-02 Pathology Tables

NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  14807966

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3|             
                                           | 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7|             
    CONTOL                                 | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +     +  +  M  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  A  +  +  +  +  +  +  +     A  +  M  +  +  +  I     +  A  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +     A  +  A  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  A  +  +  +  +  +  +  A     A  +  A  +  +  +  +     +  A  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  M  +  +  +  +  +  +  +  +     A  +  A  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +  +  M  +  +  +  +     M  +  A  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  A  +  +  +  +  +  +  +     A  +  A  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  A  +  +  M  +  M  M  A     A  M  A  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  A  +  +  +  +  +  +  A     A  +  A  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  A  +  +  +  +  +  +  +     A  +  A  +  +  +  +     +  A  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Hepatocellular Carcinoma             |                   X  X                    X                              |             
      Hepatocellular Adenoma               |                   X                                X        X            |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                       X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +     A  +  A  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                X         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3|             
                                           | 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7|             
    CONTOL                                 | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                X         |             
      Spindle Cell, Adenoma                |                         X                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Adenoma                              |                      X                                                   |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  M  +  +  +  +  +  +  +     M  +  +  +  +  +  +     +  +  +     +|             
      Pheochromocytoma Malignant           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  M  +  +  +  +  +  +  +     A  M  A  +  I  +  I     +  +  I     I|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  M  I  M  +  +  +  +  +     +  +  +  M  +  +  M     +  +  I     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +     M  +  M  +  +  +  +     +  +  +     +|             
      Adenoma                              |                   X                                            X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                   +      |             
      Fibrosarcoma                         |                                                                   X      |             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  I  +  I     +  +  +  M  +  +  +     M  +  +     +|             
      Adenocarcinoma, Metastatic, Uterus   |                                                       X                  |             
      Adenoma                              |                                                                          |             
      Luteoma                              |                                                    X                     |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Adenocarcinoma                       |                                                       X                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  A     A  +  A  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                X         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Iliac, Lymphoma Malignant            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3|             
                                           | 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7|             
    CONTOL                                 | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Undifferentiated Cell Type       |                                        X                                 |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  I  +  M     +  +  M  +  +  +  +     +  +  +     I|             
      Adenocarcinoma, Metastatic, Uterus   |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                       X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  M  +  +  M  +  +     +  +  +  +  M  M  +     +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                       X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  +  +  M  +  M  +  M  M     M  M  M  M  M  +  M     M  +  M     M|             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  M  +  +  +  +  M  +  +  M     M  +  M  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                       X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                       X         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  I     +  +  A  +  +  I  +     +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3|             
                                           | 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7|             
    CONTOL                                 | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  I  +  +  +  +  +  +  +     +  +  A  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Alveolar/Bronchiolar Adenoma         |    X                                               X                     |             
      Alveolar/Bronchiolar Carcinoma       |             X                                                            |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                           X                              |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                       X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  A  +  +  +  +  +  +  +     M  +  A  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
      Adenoma                              |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                           X                              |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                       X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3|            |
                                           | 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3|     A      |
    CONTOL                                 | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +|  43        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  A  +  +  +  A  A  M  +  +  +  A  +  +     A  +  +  +  A  A  +  +|  31        |
      Lymphoma Malignant Mixed             |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  A  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  A  +  +  +  +  A  +  +     +  +  +  +  A  A  +  +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  A  A  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  M  M  +  +  M  +  +  M  +  +  +  A  +  +     M  +  +  +  A  +  +  +|  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  +  A  +  +  +  +  A  +  +  +  +  A  +  +     A  +  +  +  A  A  +  +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  A  +  +  +  A  A  +  M  M  +  A  +  +     A  +  +  +  A  A  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  A  +  +  +  +  A  +  +  +  A  A  +  +     A  +  +  +  A  A  +  +|  33        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  M  A  +  +  +  +  A  +  +  +  +  A  +  +     A  +  +  +  A  A  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Hepatocellular Carcinoma             |                            X           X  X                 X            |          7 |
      Hepatocellular Adenoma               | X                                                                    X   |          5 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |             X                                                           X|          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                                            |   2        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     I  +  +  +  +  A  +  +|  42        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
      Lymphoma Malignant Mixed             |             X                                X                          X|          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Hemangioma                           |       X                                                                  |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  45        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3|            |
                                           | 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3|     A      |
    CONTOL                                 | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Spindle Cell, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Adenoma                              |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
      Lymphoma Malignant Mixed             |             X                                X                           |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +     I  +  +  +  +  +  +  M|  41        |
      Pheochromocytoma Malignant           |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  M  I  I  I  +  I  +  I  +  +  +  +  I  M  M     M  I  +  +  +  M  M  +|  25        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  I  +  M  M  M  +  M  +  M  +  +  I  +  +  M     M  +  M  M  M  +  M  +|  23        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +     +  +  +  +  M  +  +  +|  42        |
      Adenoma                              |                      X  X                                               X|          5 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +     +  +  +  +  A  +  +  +|  43        |
      Follicular Cell, Adenoma             |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +           +                                         +                  |   4        |
      Fibrosarcoma                         |                                                                          |          1 |
      Hemangioma                           |                                                       X                  |          1 |
      Lymphoma Malignant Mixed             |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  M  +  +  +  +  +  +  +  M  +  +  I  +  +     M  +  +  +  +  +  +  +|  38        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Adenoma                              |                                     X                                    |          1 |
      Luteoma                              |                                     X                                    |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |             X                                X                          X|          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +     +  +  +  +  M  +  +  +|  44        |
      Adenocarcinoma                       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                         X|          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3|            |
                                           | 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3|     A      |
    CONTOL                                 | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +|  41        |
      Lymphoma Malignant Mixed             |                                                                         X|          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Axillary, Lymphoma Malignant Mixed   |                                                                         X|          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                         X|          1 |
      Iliac, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                         X|          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +|  38        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
      Lymphoma Malignant Mixed             |                                              X                          X|          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  M  M  +  +  M  +     +  +  M  +  +  M  +  +|  35        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                              X                          X|          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  +  M  M  M  +  +  M  M  M  M  M  M  M     M  M  M  M  M  +  M  +|  13        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                         X|          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  I  +     +  +  +  M  M  +  M  +|  35        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
      Lymphoma Malignant Mixed             |                                              X                          X|          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  45        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                         X|          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3|            |
                                           | 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3|     A      |
    CONTOL                                 | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +     +  +  +  +  M  +  I  +|  40        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
      Lymphoma Malignant Mixed             |             X                                                           X|          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  A  +  +  +|  41        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  M  +  +  +  +  +  I  +  +  +  +     +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Alveolar/Bronchiolar Adenoma         |                   X                                                      |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                          X               |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                           X                              |          2 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
      Lymphoma Malignant Mixed             |             X                                X                          X|          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +  +  +  A  A  +  +|  40        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          1 |
      Lymphoma Malignant Mixed             |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                         +|   2        |
      Adenoma                              |                                                                         X|          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3|            |
                                           | 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3|     A      |
    CONTOL                                 | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +|  44        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                         X|          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
      Lymphoma Malignant Mixed             |             X                                X                          X|          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 0| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 2| 5| 1| 1| 2| 2| 2| 3| 0| 3| 2| 3| 9| 2| 7| 9| 3| 3| 4| 9| 1| 3| 3| 9| 2|             
                                           | 2| 9| 2| 8| 9| 9| 9| 3| 0| 0| 2| 0| 2| 8| 6| 9| 0| 0| 1| 2| 4| 1| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9| 0|             
    6 MG/M3                                | 6| 9| 0| 2| 4| 9| 0| 7| 0| 2| 3| 4| 5| 6| 8| 0| 6| 8| 1| 3| 5| 7| 9| 0| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  A  +  +  +  +  A  +     +  M  A  A  A  +  +  A  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  +  +  A  +     +  +  A  A  A  +  +  A  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  A  +  +  +  +  A  +     +  A  A  A  A  +  +  A  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  A  +     +  A  A  A  A  +  +  A  +  A  +  +  +  +|             
      Leiomyosarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  M  +  +  +  +  M  +  A  +     +  +  M  A  A  +  +  A  A  A  M  I  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  A  +  +  +  +  A  +     +  A  A  A  A  +  +  A  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  A  +  +  +  +  A  +     +  A  A  A  A  +  +  A  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  A  +  +  +  +  A  +     +  A  A  A  A  +  +  A  A  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  A  +  +  +  +  A  +     +  A  A  A  A  +  +  A  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                 X                        |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                                 X                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  I  +  +  +  +  +  A  +     +  +  I  A  A  +  +  M  +  A  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  A  +     +  +  +  A  +  +  +  A  +  A  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +     +  +  M  A  +  +  +  +  +  A  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  I  I  I  +  M  +  A  +     I  I  M  A  M  +  M  M  I  A  +  +  +  I|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  M  I  I  +  M  M     +  +  +  M  M  +  M  M  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +     +  +  I  M  I  +  +  +  M  +  +  +  +  +|             
      Adenoma                              |                                                                X  X     X|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                                         |             
      Lymphoma Malignant Mixed             |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 0| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 2| 5| 1| 1| 2| 2| 2| 3| 0| 3| 2| 3| 9| 2| 7| 9| 3| 3| 4| 9| 1| 3| 3| 9| 2|             
                                           | 2| 9| 2| 8| 9| 9| 9| 3| 0| 0| 2| 0| 2| 8| 6| 9| 0| 0| 1| 2| 4| 1| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9| 0|             
    6 MG/M3                                | 6| 9| 0| 2| 4| 9| 0| 7| 0| 2| 3| 4| 5| 6| 8| 0| 6| 8| 1| 3| 5| 7| 9| 0| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  M  M  +  +     +  +  M  A  +  +  +  +  +  +  +  +  M  +|             
      Adenoma                              |                                                                          |             
      Cystadenoma                          |                                                                         X|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | A  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Lymphoma Malignant Lymphocytic|                                        X                                 |             
      Iliac, Lymphoma Malignant Mixed      |                                                 X                        |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                        X                                 |             
      Renal, Lymphoma Malignant Mixed      |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  I  M  +  I  +  +  +  +     +  M  +  +  +  +  M  M  +  +  +  +  I  +|             
      Adenocarcinoma, Metastatic, Kidney   |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                           X                              |             
      Lymphoma Malignant Lymphocytic       |                                        X                          X      |             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  M  +  +  +  M  +     +  +  +  +  M  +  M  M  +  M  +  +  M  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                          X      |             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  M  M  +  M  M  M  +     M  M  +  M  M  +  +  +  I  M  +  +  M  M|             
      Adenocarcinoma, Metastatic, Kidney   |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                        X                          X      |             
      Lymphoma Malignant Mixed             |                                                 X  X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | A  +  +  +  +  +  +  +  A  +     I  M  +  A  +  M  +  A  +  A  +  M  +  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  A  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                          X      |             
      Lymphoma Malignant Mixed             |                X                                X                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  I  +  +  +  +  +  +     +  M  +  M  I  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                        X                          X      |             
      Lymphoma Malignant Mixed             |                X                                X  X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 0| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 2| 5| 1| 1| 2| 2| 2| 3| 0| 3| 2| 3| 9| 2| 7| 9| 3| 3| 4| 9| 1| 3| 3| 9| 2|             
                                           | 2| 9| 2| 8| 9| 9| 9| 3| 0| 0| 2| 0| 2| 8| 6| 9| 0| 0| 1| 2| 4| 1| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9| 0|             
    6 MG/M3                                | 6| 9| 0| 2| 4| 9| 0| 7| 0| 2| 3| 4| 5| 6| 8| 0| 6| 8| 1| 3| 5| 7| 9| 0| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  M  +  I  +  +  +  +  +  +  I  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vertebra, Alveolar/Bronchiolar       |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  A  +  +  +  +  A  +     +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Kidney   |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |    X                             X                                       |             
      Alveolar/Bronchiolar Carcinoma       |                                           X                              |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                        X                          X      |             
      Lymphoma Malignant Mixed             |                                                 X  X                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  A  +     +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  A  +  +  +  +  A  +     +  +  A  M  +  +  +  A  +  A  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +     +  A  +  A  +  +  +  A  +  A  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                          X      |             
      Lymphoma Malignant Mixed             |                X                                X  X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3|            |
                                           | 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8|     A      |
    6 MG/M3                                | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  M  A  +  A  A  +  M  A  +  +  A  +  +  +  +  A  +  A  +  +  +|  29        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  A  A  +  +  A  +  A  A  +  +  +  +  +  +  +  +  +  A  A  +  +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  A  +  +  A  +  A  A  +  +  A  +  +  +  +  A  +  A  A  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  A  +  +  A  +  A  A  +  +  +  +  +  +  +  +  +  A  A  +  +|  34        |
      Leiomyosarcoma                       |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  A  A  +  M  A  +  A  A  +  +  M  I  +  +  M  +  +  A  M  +  M|  23        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  A  +  +  A  +  A  A  +  +  A  +  +  +  +  A  +  A  A  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  A  A  +  +  A  +  A  A  +  I  A  +  +  +  +  A  +  A  A  M  M|  26        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  A  A  +  +  A  +  A  A  +  +  A  +  +  +  +  A  +  A  A  +  +|  28        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  A  +  +  A  +  A  A  +  +  A  +  +  M  +  A  +  A  A  +  +|  29        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hemangioma                           |                                                                          |          1 |
      Hepatocellular Carcinoma             |          X              X     X        X                                X|          5 |
      Hepatocellular Adenoma               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  40        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  A  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +|  40        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  I  A  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | I  +  I  +  A  M  M  M  +  I  M  I  I  +  I  +  +  +  +  +  +  M  I  +  +|  21        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  A  I  I  +  +  M  I  +  M  I  M  +  M  M  +  M  I  M  +  M  +|  19        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  43        |
      Adenoma                              |                                                       X                  |          4 |
      Carcinoma                            |                                           X              X               |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3|            |
                                           | 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8|     A      |
    6 MG/M3                                | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Adenoma             |                                                       X                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Adenoma                              |                                     X                                    |          1 |
      Cystadenoma                          |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Iliac, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  I  +  +  +  +  +  +  M  +  +|  37        |
      Adenocarcinoma, Metastatic, Kidney   |                         X                                                |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |             X     X                                                      |          3 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  38        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  +  +  M  +  M  +  M  +  +  M  M  M  M  M  M  +  M  M  M  M  M  M|  17        |
      Adenocarcinoma, Metastatic, Kidney   |                         X                                                |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                   X                                                      |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  I  A  M  +  +  +  +  M  +  +  M  +  +  +  +  M  M  +  +  M  +  +|  32        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3|            |
                                           | 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8|     A      |
    6 MG/M3                                | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  M  +  +  +  I  +  +  +  +  M  +  +  +  +  +|  41        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |             X     X                                                      |          2 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Vertebra, Alveolar/Bronchiolar       |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenocarcinoma, Metastatic, Kidney   |                         X                                                |          1 |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |    X        X     X                                                      |          4 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |          X              X                                                |          2 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  M  M  M|  37        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +              +                                                   |   2        |
      Adenoma                              |       X                                                                  |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3|            |
                                           | 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8|     A      |
    6 MG/M3                                | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Adenocarcinoma                       |                         X                                                |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  41        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          3 |
      Lymphoma Malignant Mixed             | X                                                                        |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3|             
                                           | 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8|             
    18 MG/M3                               | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  M  M  A  A  A  M  +  A  A  +  A  +  A  +  A  +  M  +  M  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  A  A  +  +  A  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  A  A  +  A  A  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Leiomyoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  A  A  +  A  A  A  +  A  A  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  A  M  +  +  A  A  +  A  M  +  +  +  +  +  M  M  +  +  +  M  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  A  A  +  A  A  A  +  A  A  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  A  A  +  A  A  A  M  A  A  +  A  M  A  +  M  +  +  +  +  M  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  A  A  A  A  A  A  +  A  A  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  A  +  A  A  A  +  A  A  +  A  +  A  +  A  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                      X                                X                  |             
      Hepatocellular Adenoma               |                                                       X              X   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  A  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | I  I  +  M  +  +  I  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  M  I  M  A  M  +  +  M  I  +  M  I  I  M  +  I  +  I  +  I  A  I  I|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  +  +  M  M  M  I  +  I  +  +  M  +  +  +  +  +  I  M  M  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X     X                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                             X           X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3|             
                                           | 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8|             
    18 MG/M3                               | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma Adenosquamous              |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Lymphoma Malignant Mixed   |                                                                   X      |             
      Iliac, Lymphoma Malignant Lymphocytic|                                                                          |             
      Iliac, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                   X      |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  I  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  +  M  +  +  +  M  +  +  +  +  +  +  M  +  I  +  +  M  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  M  M  M  M  M  +  +  M  M  M  M  M  +  M  M  +  M  M  +  +  M  M|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3|             
                                           | 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8|             
    18 MG/M3                               | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  A  A  +  M  M  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  +  I  +  +  +  M  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                      +                                                   |             
      Thoracic, Ganglioneuroma             |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  M  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                              X                           |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hemangiosarcoma, Metastatic, Tissue  |                                                                          |             
          NOS                              |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3|             
                                           | 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8|             
    18 MG/M3                               | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenocarcinoma                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6|            |
                                           | 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     T      |
                               ANIMAL ID   | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6|     A      |
    18 MG/M3                               | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +  +  +  +  A  +  +  +  +  +  A  +  +  M  +  A  +  +  +  +  A|  29        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  A  +  A  +  +  A  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  A|  36        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  A  +  +  A  +  +  +  +  +  A  +  +  +  A  A  +  +  +  +  A|  34        |
      Leiomyoma                            |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  A  +  +  A  +  +  +  +  +  A  +  +  I  A  A  +  +  +  +  A|  32        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  +  M  M  +  A  +  M  +  M  +  A  +  I  M  M  +  I  +  +  +  A|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  A  +  A  +  +  A  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  A|  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  M  A  +  A  +  +  A  +  +  +  +  +  A  +  +  +  A  A  +  +  +  +  A|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  A  +  +  A  +  +  +  +  +  A  +  A  +  A  A  +  +  +  +  A|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  A  +  +  A  +  +  +  +  +  A  +  A  +  A  +  +  +  +  +  A|  31        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                   X           X                                          |          4 |
      Hepatocellular Adenoma               | X  X                                                                     |          4 |
      Lymphoma Malignant Histiocytic       |                                           X                              |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                       X           X      |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  44        |
      Lymphoma Malignant Histiocytic       |                                           X                              |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  I|  46        |
      Lymphoma Malignant Histiocytic       |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                           X                              |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  A  +  +  +  M  +  I  +  M  I  +  M  +  +  +  +  +  I  I  +  I  I|  23        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  I  +  +  +  M  M  M  +  M  +  M  M  +  +  M  I  M  +  +|  25        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6|            |
                                           | 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     T      |
                               ANIMAL ID   | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6|     A      |
    18 MG/M3                               | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +                                                  +                     |   2        |
      Hemangioma                           | X                                                                        |          1 |
      Hemangiosarcoma                      |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  M  +  +  M  +  +  +  +  +  +|  46        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Carcinoma Adenosquamous              |                                                                   X      |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                   X      |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A|  45        |
      Lymphoma Malignant Mixed             |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Axillary, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Iliac, Lymphoma Malignant Lymphocytic|                      X                                                   |          1 |
      Iliac, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                   X      |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                              X                           |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                              X                           |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Lymphoma Malignant Histiocytic       |                                           X                              |          1 |
      Lymphoma Malignant Lymphocytic       |                      X                       X                           |          2 |
      Lymphoma Malignant Mixed             |    X                                                                     |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                       X           X      |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6|            |
                                           | 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     T      |
                               ANIMAL ID   | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6|     A      |
    18 MG/M3                               | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  M  +  +  +  +  M|  36        |
      Lymphoma Malignant Histiocytic       |                                           X                              |          1 |
      Lymphoma Malignant Lymphocytic       |                      X        X              X                           |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                       X           X      |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  M  M  M  +  +  M  M  +  M  M  M  M  M  M  M  +  M  M  M  +  M  M|  14        |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                       X           X      |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  M  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|  37        |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                       X           X      |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                              X                           |          1 |
      Lymphoma Malignant Histiocytic       |                                           X                              |          1 |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                       X           X      |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  I  +|  41        |
      Lymphoma Malignant Histiocytic       |                                           X                              |          1 |
      Lymphoma Malignant Lymphocytic       |                                              X                           |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                       X           X      |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibrosarcoma                         |                                        X                                 |          1 |
      Lymphoma Malignant Histiocytic       |                                           X                              |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6|            |
                                           | 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     T      |
                               ANIMAL ID   | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6|     A      |
    18 MG/M3                               | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Thoracic, Ganglioneuroma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                      X                                                   |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                          X               |          1 |
      Hemangiosarcoma, Metastatic, Tissue  |                                                                          |            |
          NOS                              |                                                    X                     |          1 |
      Lymphoma Malignant Histiocytic       |                                           X                              |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                       X           X      |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  M  +  I  +  A  +  +  +  M  +  +  +  +  +  +|  45        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   1        |
      Adenocarcinoma                       |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +  A  +  +  A  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|  41        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                           X                              |          1 |
      Lymphoma Malignant Lymphocytic       |                      X        X              X                           |          3 |
      Lymphoma Malignant Mixed             |    X                                                                     |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                       X           X      |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 3| 1| 5| 1| 7| 1| 5| 5| 4| 7| 5| 5| 0| 1| 7| 7| 7| 7| 3| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 4| 6| 8| 4| 8| 1| 8| 4| 4| 0| 1| 4| 3| 2| 8| 3| 0| 3| 3| 6| 0| 3| 5|             
                                           | 2| 2| 9| 9| 5| 9| 5| 1| 6| 9| 9| 4| 5| 9| 2| 8| 6| 2| 1| 2| 2| 8| 4| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 7|             
    CONTROL                                | 8| 9| 0| 3| 5| 7| 8| 6| 7| 8| 0| 2| 3| 4| 9| 6| 7| 8| 9| 7| 8| 9| 6| 8| 2|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  I  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  M  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       M  +  M           +  M           M                                 |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  M           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |       +  +  +           +  M           +                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +  M  +           M  +           M                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |       +  +  M           M  +           +                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 3| 1| 5| 1| 7| 1| 5| 5| 4| 7| 5| 5| 0| 1| 7| 7| 7| 7| 3| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 4| 6| 8| 4| 8| 1| 8| 4| 4| 0| 1| 4| 3| 2| 8| 3| 0| 3| 3| 6| 0| 3| 5|             
                                           | 2| 2| 9| 9| 5| 9| 5| 1| 6| 9| 9| 4| 5| 9| 2| 8| 6| 2| 1| 2| 2| 8| 4| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 7|             
    CONTROL                                | 8| 9| 0| 3| 5| 7| 8| 6| 7| 8| 0| 2| 3| 4| 9| 6| 7| 8| 9| 7| 8| 9| 6| 8| 2|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  M           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +           +  +           +                                 |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 3| 1| 3| 5| 1| 3| 1| 5| 3| 6| 5| 3|                                |            |
                             DAY ON TEST   | 8| 3| 6| 8| 6| 4| 8| 6| 8| 5| 6| 9| 7| 6|                                |            |
                                           | 6| 2| 8| 6| 9| 9| 7| 9| 7| 0| 9| 4| 6| 9|                                |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                |     T      |
                               ANIMAL ID   | 7| 7| 9| 9| 0| 0| 0| 1| 2| 3| 3| 3| 3| 4|                                |     A      |
    CONTROL                                | 6| 7| 8| 9| 3| 6| 8| 0| 6| 2| 5| 6| 7| 0|                                |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M           +  +  +           +                                          |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +           +  +  +           +                                          |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +           +  M  +           +                                          |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +           +  +  +           +                                          |  11        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +           +  +  +           +                                          |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +           +  M  M           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +           +  +  M           +                                          |  10        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +           +  M  +           +                                          |   9        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                 +                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +           +  +  +           +                                          |  11        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +  +  +           +                                          |  11        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 3| 1| 3| 5| 1| 3| 1| 5| 3| 6| 5| 3|                                |            |
                             DAY ON TEST   | 8| 3| 6| 8| 6| 4| 8| 6| 8| 5| 6| 9| 7| 6|                                |            |
                                           | 6| 2| 8| 6| 9| 9| 7| 9| 7| 0| 9| 4| 6| 9|                                |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                |     T      |
                               ANIMAL ID   | 7| 7| 9| 9| 0| 0| 0| 1| 2| 3| 3| 3| 3| 4|                                |     A      |
    CONTROL                                | 6| 7| 8| 9| 3| 6| 8| 0| 6| 2| 5| 6| 7| 0|                                |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +           M  +  +           +                                          |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +           +  +  M           +                                          |   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +           M  M  M           M                                          |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +           +  +  +           +                                          |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +           +  +  +           +                                          |  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +           +  +  +           +                                          |  11        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +           +  +  +           +                                          |  11        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +           +  +  +           +                                          |  11        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +           +  +  +           +                                          |  11        |
      Alveolar/Bronchiolar Adenoma         |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +           +  +  +           +                                          |  11        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +           +  +  +           +                                          |  11        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +           +  +  +           +                                          |  11        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 5| 3| 3| 7| 1| 7| 6| 3| 1| 1| 6| 5| 7| 7| 1| 5| 0| 6| 7| 1| 3| 0| 5|             
                             DAY ON TEST   | 6| 4| 4| 6| 6| 1| 8| 3| 5| 6| 8| 8| 5| 4| 3| 3| 8| 4| 1| 7| 3| 8| 6| 0| 2|             
                                           | 9| 9| 9| 8| 9| 7| 5| 2| 9| 8| 5| 6| 5| 9| 2| 2| 6| 9| 7| 8| 2| 7| 9| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 2| 2| 4| 4| 4| 5| 5| 5| 7| 7| 8| 8| 8| 8| 8| 1| 1| 1| 1|             
    6 MG/M3                                | 7| 8| 1| 3| 5| 6| 7| 8| 6| 8| 9| 1| 7| 9| 7| 9| 0| 2| 4| 6| 8| 0| 2| 3| 4|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +        M     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +        +     M              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +        +     +              +     +           +              M      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +        +     +              +     M           +              +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +        +     +              +     +           +              +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +        +     +              +     +           +              +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +        +     +              +     +                          +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +        +     +              +     +                          +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +        +     +              +     M           +              +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +        +     M              M     M           M              M      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +        +     M              M     +           +              +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +        +     +              +     +           M              +      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +           +                                                     +      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +        M     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +        +     +              +     +           +              +      |             
      Endometrium, Polyp                   |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +        +     M              +     +           +              M      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +        +     M              +     M           +              M      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +        +     +              +     +           +              +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 5| 3| 3| 7| 1| 7| 6| 3| 1| 1| 6| 5| 7| 7| 1| 5| 0| 6| 7| 1| 3| 0| 5|             
                             DAY ON TEST   | 6| 4| 4| 6| 6| 1| 8| 3| 5| 6| 8| 8| 5| 4| 3| 3| 8| 4| 1| 7| 3| 8| 6| 0| 2|             
                                           | 9| 9| 9| 8| 9| 7| 5| 2| 9| 8| 5| 6| 5| 9| 2| 2| 6| 9| 7| 8| 2| 7| 9| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 2| 2| 4| 4| 4| 5| 5| 5| 7| 7| 8| 8| 8| 8| 8| 1| 1| 1| 1|             
    6 MG/M3                                | 7| 8| 1| 3| 5| 6| 7| 8| 6| 8| 9| 1| 7| 9| 7| 9| 0| 2| 4| 6| 8| 0| 2| 3| 4|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +        +     +              +     +           +              +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +        +     +              +     +           +              +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +        +     +              +     +           +              +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +        +     +              +     +           +              +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +        +     +              +     +           +              +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                        +                                 |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +        +     +              +     +           +              +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +        +     +              +     +           +              +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4| 6| 5| 1| 3| 1| 5| 3| 7| 3| 7| 5| 1|                             |            |
                             DAY ON TEST   | 4| 9| 5| 1| 5| 8| 6| 8| 4| 6| 3| 6| 3| 5| 8|                             |            |
                                           | 9| 7| 3| 7| 0| 7| 9| 7| 9| 9| 2| 9| 2| 0| 7|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     T      |
                               ANIMAL ID   | 1| 1| 3| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7|                             |     A      |
    6 MG/M3                                | 6| 9| 7| 1| 2| 3| 6| 9| 0| 7| 0| 3| 4| 7| 9|                             |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +     +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                +     +  +  M                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +     +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +     +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +     +  +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                M     +  +  +                                             |  11        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                +     +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                I     +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +     +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                M     M  +  M                                             |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                M     M  +  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                M     M  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                            +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                +     +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                +     +  +  +                                             |  12        |
      Endometrium, Polyp                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +     +  +  +                                             |  12        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4| 6| 5| 1| 3| 1| 5| 3| 7| 3| 7| 5| 1|                             |            |
                             DAY ON TEST   | 4| 9| 5| 1| 5| 8| 6| 8| 4| 6| 3| 6| 3| 5| 8|                             |            |
                                           | 9| 7| 3| 7| 0| 7| 9| 7| 9| 9| 2| 9| 2| 0| 7|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     T      |
                               ANIMAL ID   | 1| 1| 3| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7|                             |     A      |
    6 MG/M3                                | 6| 9| 7| 1| 2| 3| 6| 9| 0| 7| 0| 3| 4| 7| 9|                             |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                M     M  +  M                                             |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +     +  M  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                M     M  M  M                                             |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +     +  M  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +     +  +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +     +  +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +     +  +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +     +  +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Nose                                    |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                M     +  +  +                                             |  11        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +     +  +  +                                             |  12        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                +     +  +  +                                             |  12        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 1| 7| 0| 0| 4| 3| 1| 7| 3| 5| 3| 7| 5| 1| 2| 3| 5| 1| 5| 1| 5| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 9| 6| 8| 3| 6| 4| 6| 3| 0| 8| 8| 6| 4| 8| 4| 8| 4| 3| 3|             
                                           | 8| 8| 4| 2| 8| 8| 5| 9| 6| 2| 8| 6| 9| 2| 8| 5| 6| 8| 9| 7| 9| 5| 9| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 9| 9| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 5| 5| 6| 6| 6| 6| 6| 6| 8| 9| 9| 9|             
    18 MG/M3                               | 7| 8| 9| 0| 5| 8| 9| 6| 0| 1| 3| 5| 7| 7| 8| 2| 3| 4| 5| 8| 9| 7| 1| 3| 5|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                      M              +        +              +            |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                      M              M        +              +            |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Liver                                   |                      +              +        +              +            |             
      Hepatocellular Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Stomach                                 |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                      +              I        +              +            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                      M              +        +              +            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                      M              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                      +              +                                    |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Uterus                                  |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                      I              M        M              M            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 1| 7| 0| 0| 4| 3| 1| 7| 3| 5| 3| 7| 5| 1| 2| 3| 5| 1| 5| 1| 5| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 9| 6| 8| 3| 6| 4| 6| 3| 0| 8| 8| 6| 4| 8| 4| 8| 4| 3| 3|             
                                           | 8| 8| 4| 2| 8| 8| 5| 9| 6| 2| 8| 6| 9| 2| 8| 5| 6| 8| 9| 7| 9| 5| 9| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 9| 9| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 5| 5| 6| 6| 6| 6| 6| 6| 8| 9| 9| 9|             
    18 MG/M3                               | 7| 8| 9| 0| 5| 8| 9| 6| 0| 1| 3| 5| 7| 7| 8| 2| 3| 4| 5| 8| 9| 7| 1| 3| 5|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Thymus                                  |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Skin                                    |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Lung                                    |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Nose                                    |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Trachea                                 |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                      +              +        +              +            |             
      Transitional Epithelium, Papilloma   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 3| 1| 1| 5| 5| 5| 3| 5| 6| 1| 3| 7| 5| 3|                             |            |
                             DAY ON TEST   | 8| 6| 8| 8| 4| 4| 5| 6| 4| 0| 8| 6| 3| 5| 6|                             |            |
                                           | 6| 9| 7| 7| 9| 9| 0| 9| 9| 4| 7| 9| 2| 0| 9|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                             |     T      |
                               ANIMAL ID   | 9| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 5| 5| 5| 5|                             |     A      |
    18 MG/M3                               | 7| 0| 8| 0| 1| 3| 5| 7| 0| 7| 8| 0| 1| 6| 7|                             |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +        +        M                                       |  10        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +  +  +  +        +        +                                       |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  +        +        +                                       |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +        +        +                                       |  12        |
      Hepatocellular Adenoma               |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +        +        +                                       |  12        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +        +        +                                       |  12        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | M  +  +  +  +  +        +        +                                       |  11        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +        +        +                                       |  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  M  +        +        +                                       |   8        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +        +        +                                       |  11        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +                             +                                       |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +        +        +                                       |  12        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +        A        +                                       |  11        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  36                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 3| 1| 1| 5| 5| 5| 3| 5| 6| 1| 3| 7| 5| 3|                             |            |
                             DAY ON TEST   | 8| 6| 8| 8| 4| 4| 5| 6| 4| 0| 8| 6| 3| 5| 6|                             |            |
                                           | 6| 9| 7| 7| 9| 9| 0| 9| 9| 4| 7| 9| 2| 0| 9|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE FEMALE                      | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                             |     T      |
                               ANIMAL ID   | 9| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 5| 5| 5| 5|                             |     A      |
    18 MG/M3                               | 7| 0| 8| 0| 1| 3| 5| 7| 0| 7| 8| 0| 1| 6| 7|                             |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | I  +  +  +  +  +        +        +                                       |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M        +        +                                       |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M  M  M  M        M        M                                       |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     M        +        +                                       |  10        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +        +        +                                       |  12        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +        +        +                                       |  12        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +        +        +                                       |  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +        +        +                                       |  12        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +        +        +                                       |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +        +        +                                       |  12        |
      Transitional Epithelium, Papilloma   |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +        +        +                                       |  12        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +        +        +                                       |  12        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 2| 3| 3| 3| 7| 3| 3| 3| 4| 4| 3| 3| 0|             
                                           | 6| 6| 6| 6| 6| 8| 6| 6| 2| 6| 0| 5| 0| 7| 7| 7| 1| 7| 7| 7| 0| 0| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 6| 6| 6| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3|             
    CONTROL                                | 1| 4| 7| 0| 1| 2| 4| 5| 1| 2| 3| 5| 6| 8| 2| 3| 5| 1| 3| 4| 6| 7| 1| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  M  +  +  M     +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  M  +  +  A  A  +  M  +  +  +     +  +  M  A  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  A  A  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  A  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  A  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  A  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  A  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  A  +  A  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  A  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  A  +  +  +  +  +     +  +  +  A  +  +  M  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Metastatic, Spleen  |                                                                   X      |             
      Hepatocellular Carcinoma             | X  X                                            X                        |             
      Hepatocellular Adenoma               |                                                                          |             
      Hepatocellular Adenoma, Multiple     |                                                    X                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  M|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  I     +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  M  A  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | I  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
      Spindle Cell, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | I  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  +  +  +  +  M  M  M  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
      Pheochromocytoma Malignant           |                                                                X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  M  +  M  +  +  I  M     +  +  +  A  +  M  I  +  +  I  +  M|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  +  M  M  M  M  +  M  +     +  M  +  +  +  +  M  M  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  I  +     +  +  +  +  +  +  +  +  +  +  +  M|             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 2| 3| 3| 3| 7| 3| 3| 3| 4| 4| 3| 3| 0|             
                                           | 6| 6| 6| 6| 6| 8| 6| 6| 2| 6| 0| 5| 0| 7| 7| 7| 1| 7| 7| 7| 0| 0| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 6| 6| 6| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3|             
    CONTROL                                | 1| 4| 7| 0| 1| 2| 4| 5| 1| 2| 3| 5| 6| 8| 2| 3| 5| 1| 3| 4| 6| 7| 1| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  M  +  +  M  +  +  I  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                                                                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  I  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
      Hemangiosarcoma                      |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  A  +  +  +  +  +  A     +  +  +  A  +  +  +  +  +  +  +  A|             
      Hemangiosarcoma, Metastatic, Spleen  |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  M|             
      Iliac, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  I  +  +     +  M  +  +  +  +  +  +  M  M  +  M|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  M  +  M  +  +  M  M  M  M     +  M  M  M  +  +  +  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  M  M  M  I  +  M  M  +  +     M  M  M  M  +  M  M  M  M  M  M  M|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  I  M  +  M  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  M|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                           X                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
      Hemangiosarcoma                      |                                                                   X  X   |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  M  +  +  I  I  +  M     +  +  +  A  +  +  +  +  +  +  +  M|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  +  +     M  M  M  +  M  M  M  M  +  M  M  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 2| 3| 3| 3| 7| 3| 3| 3| 4| 4| 3| 3| 0|             
                                           | 6| 6| 6| 6| 6| 8| 6| 6| 2| 6| 0| 5| 0| 7| 7| 7| 1| 7| 7| 7| 0| 0| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 6| 6| 6| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3|             
    CONTROL                                | 1| 4| 7| 0| 1| 2| 4| 5| 1| 2| 3| 5| 6| 8| 2| 3| 5| 1| 3| 4| 6| 7| 1| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  I  +  +  +  +  +  I  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
      Alveolar/Bronchiolar Adenoma         |       X                                      X     X     X               |             
      Alveolar/Bronchiolar Carcinoma       |                            X              X  X              X            |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |    X                                                                     |             
      Hemangiosarcoma, Metastatic, Liver   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                          |             
      Adenoma                              |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6|  |            |
                             DAY ON TEST   | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9|  |            |
                                           | 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|  |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2|  |     A      |
    CONTROL                                | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5|  |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +      |  41        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  +     +  +  +  +  +  +  +  +  A  M  +  M  A  A  +  +  A      |  31        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A  +  +     +  +  +  +  +  +  +  +  A  A  +  A  A  A  +  +  +      |  36        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +     +  +  +  +  +  A  +  +  A  A  +  A  A  A  +  +  A      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +     +  +  +  +  +  +  +  +  A  A  +  A  A  A  +  +  +      |  36        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | I  +  A  +  +     +  +  +  +  +  A  +  M  A  A  +  A  A  A  +  +  M      |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  +  +     +  +  +  +  +  A  +  +  A  A  +  A  A  A  +  +  A      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +     +  +  +  M  +  A  +  +  A  A  +  A  A  A  +  +  A      |  32        |
      Lymphoma Malignant Mixed             |                                                 X                        |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +     +  +  +  +  +  A  +  A  A  A  +  A  A  A  +  +  A      |  33        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +     +  +  +  +  +  A  +  A  A  A  +  A  A  A  +  +  A      |  32        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Hemangiosarcoma                      |                                                       X                  |          1 |
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                    X  X  X               |          6 |
      Hepatocellular Adenoma               |                               X                                          |          1 |
      Hepatocellular Adenoma, Multiple     |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +      |  42        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M      |  43        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  I  +      |  39        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  43        |
      Spindle Cell, Adenoma                |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  43        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I      |  39        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6|  |            |
                             DAY ON TEST   | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9|  |            |
                                           | 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|  |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2|  |     A      |
    CONTROL                                | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5|  |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Malignant           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  I  M  +     M  I  +  I  I  +  M  I  +  +  +  +  I  A  M  +  +      |  26        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  M     +  +  +  +  +  +  M  M  M  +  M  +  +  +  +  M  +      |  25        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
      Adenoma                              |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  M  +     +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +      |  39        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +              +  +        +     +                 +  +            |   8        |
                                            __________________________________________________________________________|____________|
   Prostate                                | M  +  M  I  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +      |  40        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  A  +  +  A  A  +  +  A      |  41        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +      |  43        |
      Hemangiosarcoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +      |  40        |
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Iliac, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       | X                                                                        |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       | X                                                                        |          1 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +     +  +  +  +  M  +  +  +  M  I  M  +  +  I  M  M  I      |  32        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  M  +     +  M  +  +  +  M  +  +  +  M  M  M  M  M  +  +  M      |  23        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  M  M     M  M  M  M  +  M  M  M  +  M  M  M  M  M  +  M  M      |   9        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  A  +  +     +  +  +  I  +  M  +  +  +  M  +  +  +  A  +  +  +      |  36        |
      Lymphoma Malignant Mixed             |                                                 X                        |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6|  |            |
                             DAY ON TEST   | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9|  |            |
                                           | 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|  |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2|  |     A      |
    CONTROL                                | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5|  |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
      Hemangiosarcoma                      |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                 X                        |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | I  +  M  +  +     +  +  +  +  +  +  +  I  M  M  +  +  +  +  +  +  +      |  34        |
      Lymphoma Malignant Mixed             |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M     +  M  I  M  M  M  M  M  M  M  M  M  M  I  M  M  M      |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  I  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +      |  44        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  42        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Alveolar/Bronchiolar Adenoma         |    X        X                                                            |          6 |
      Alveolar/Bronchiolar Carcinoma       |                      X                                         X         |          6 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Hemangiosarcoma, Metastatic, Liver   |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +      |  42        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Carcinoma, Metastatic, Uncertain     |                                                                          |            |
          Primary Site                     |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +      |  43        |
      Sarcoma                              |                                                          X               |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6|  |            |
                             DAY ON TEST   | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9|  |            |
                                           | 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|  |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2|  |     A      |
    CONTROL                                | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5|  |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |    X                                            X                        |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        | X                             X                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 6| 5| 6| 3| 6| 7| 7| 7| 3| 7| 7| 6| 0|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 1| 4| 3| 5| 3| 3| 5| 2| 4| 8| 3| 3| 3| 2| 3| 3| 2| 6|             
                                           | 6| 6| 6| 3| 6| 6| 6| 0| 0| 7| 3| 7| 3| 8| 4| 4| 8| 7| 7| 7| 0| 7| 7| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7|             
    6 MG/M3                                | 1| 4| 5| 7| 8| 0| 4| 5| 2| 3| 5| 6| 8| 0| 1| 2| 1| 4| 5| 6| 8| 1| 2| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  +  +  +  A  +  +  A  +  A  A  +  I  +  +  +  I     +  +  I   |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +  A  +  A  A  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  A  +  +  A  +  A  A  +  +  +  +  +  +     +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  A  +  A  A  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  A  I  A  M  +  +  +  +  +  +     M  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  A  +  +  A  +  A  A  +  +  +  +  +  +     +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  M  +  +  A  +  M  A  +  A  A  +  +  +  +  +  +     +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  A  +  +  A  +  A  A  +  A  +  +  +  +     +  +  A   |             
      Adenocarcinoma                       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  A  +  +  A  +  A  A  +  +  +  +  M  +     +  +  A   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Hepatocellular Carcinoma             |                   X                 X  X                                 |             
      Hepatocellular Adenoma               |       X        X     X              X                             X      |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +     +  +  +   |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  A  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +     +  +  I   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +     +  +  +   |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Spindle Cell, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Adenoma                              |                                                                          |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +     +  +  I   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +  A  M  I  M  +  M  +  M  I  M  M  +  M  M  +  I  +     I  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  M  M  M  +  +  M  M  +  M  M  +  M  +  +  I  M     I  M  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +     +  +  +   |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 6| 5| 6| 3| 6| 7| 7| 7| 3| 7| 7| 6| 0|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 1| 4| 3| 5| 3| 3| 5| 2| 4| 8| 3| 3| 3| 2| 3| 3| 2| 6|             
                                           | 6| 6| 6| 3| 6| 6| 6| 0| 0| 7| 3| 7| 3| 8| 4| 4| 8| 7| 7| 7| 0| 7| 7| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7|             
    6 MG/M3                                | 1| 4| 5| 7| 8| 0| 4| 5| 2| 3| 5| 6| 8| 0| 1| 2| 1| 4| 5| 6| 8| 1| 2| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +              +                           |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  M  +  +  I  +  A  +  +  +  +  +  +  +  +  +     M  +  +   |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                                      +                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +   |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  +  +  +  +  +  +  I  +  +  M  M  +  +     +  +  +   |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  M  M  +  M  +  +  +  M  +  M  +  +  +  M  M  +  M     M  M  M   |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  M  M  M  M  M  M  +  M  M  +  M  M  M  M  M  M  M  +     M  M  M   |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  M  +  +  +  M  +  +  M  +  M  +  +  M  +  +  +  +     +  +  +   |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  A  +  M  +  M  M  M  I  +  +     +  M  +   |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  M  M  M  M  M  +  M  M  M  M  M  M  M  +  M  M  M     M  M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  I  +  M  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  I  +  A  +  +  +  +  +  +  A  +  A  A  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Alveolar/Bronchiolar Adenoma         | X                 X                                            X         |             
      Alveolar/Bronchiolar Carcinoma       |                                        X                                 |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 6| 5| 6| 3| 6| 7| 7| 7| 3| 7| 7| 6| 0|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 1| 4| 3| 5| 3| 3| 5| 2| 4| 8| 3| 3| 3| 2| 3| 3| 2| 6|             
                                           | 6| 6| 6| 3| 6| 6| 6| 0| 0| 7| 3| 7| 3| 8| 4| 4| 8| 7| 7| 7| 0| 7| 7| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7|             
    6 MG/M3                                | 1| 4| 5| 7| 8| 0| 4| 5| 2| 3| 5| 6| 8| 0| 1| 2| 1| 4| 5| 6| 8| 1| 2| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  I  +  +  +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  A  +  +  +  A  +  +  A  +  A  A  +  +  +  +  +  +     +  +  +   |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 7| 2| 7| 5| 7| 7| 5| 6| 7| 7| 5|  |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 8| 3| 3| 4| 4| 4| 3| 9| 2| 5| 3| 8| 1| 3| 9| 8| 4| 4| 5|  |            |
                                           | 0| 8| 8| 8| 8| 5| 8| 8| 6| 0| 0| 9| 1| 2| 3| 9| 4| 9| 9| 0| 1| 0| 0| 0|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6|  |     A      |
    6 MG/M3                                | 2| 3| 5| 6| 9| 0| 1| 5| 1| 4| 5| 7| 9| 2| 3| 5| 1| 4| 5| 6| 7| 8| 2| 4|  |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  +  M  A  +  +  +  A  M  M  +  A  A  +  +  A  +  +  A   |  29        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  A   |  38        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  A  +  +  +  A  +  A  +  A  +  +  +  +  +  +  A   |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  A   |  38        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  +  +  +  A  +  +  A  +  +  +  A  +  +  +  A  M  +  +  +  +  M  A   |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  A  +  +  +  A  A  A  +  A  +  +  +  +  +  +  A   |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  A  +  +  +  A  A  A  +  A  +  +  A  A  +  +  A   |  30        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  A  +  +  +  A  A  A  +  A  +  +  +  A  +  +  A   |  32        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  A  +  +  +  A  A  A  +  A  A  +  +  +  M  +  A   |  31        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Hepatocellular Carcinoma             |                         X                          X                     |          5 |
      Hepatocellular Adenoma               | X                          X  X                                          |          8 |
      Hepatocellular Adenoma, Multiple     |                                  X                                       |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | I  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A   |  39        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  43        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  A   |  41        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  43        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                      +     +              +                              |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Spindle Cell, Adenoma                |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Adenoma                              |       X                                                                  |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  I  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +   |  39        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | I  I  I  M  I  I  I  I  M  +  I  +  +  +  A  +  M  +  +  +  +  +  +  A   |  20        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  48                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 7| 2| 7| 5| 7| 7| 5| 6| 7| 7| 5|  |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 8| 3| 3| 4| 4| 4| 3| 9| 2| 5| 3| 8| 1| 3| 9| 8| 4| 4| 5|  |            |
                                           | 0| 8| 8| 8| 8| 5| 8| 8| 6| 0| 0| 9| 1| 2| 3| 9| 4| 9| 9| 0| 1| 0| 0| 0|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6|  |     A      |
    6 MG/M3                                | 2| 3| 5| 6| 9| 0| 1| 5| 1| 4| 5| 7| 9| 2| 3| 5| 1| 4| 5| 6| 7| 8| 2| 4|  |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  +  +  M  M  +  +  +  +  M  M  M  +  M  +  M  M  M  +  +  I   |  21        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +   |  44        |
      Pars Intermedia, Adenoma             |                   X                                         X            |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +   |  46        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                           +                              |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  I  A  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  I  +  +   |  39        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                                   +     +           +                  |   6        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  43        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  43        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  44        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  A  +  +  A  +  +  +  A   |  42        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +   |  39        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M  +  M  +  +  +  M  +  +  +  M  +  M  M  +  +  M  +  M  M  M  +   |  23        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M  +  M  M  M  +  M  M  M  M  +  +  M  M  M  M  M  M  M  M  +  +   |  10        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M   |  39        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  44        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  I  +  +  I  +  +  +  +  +  M  +  +  M  +  I  +  +  +  +  +  I  +   |  33        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  +  M  M  M  M  M  A   |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  45        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  49                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 7| 2| 7| 5| 7| 7| 5| 6| 7| 7| 5|  |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 8| 3| 3| 4| 4| 4| 3| 9| 2| 5| 3| 8| 1| 3| 9| 8| 4| 4| 5|  |            |
                                           | 0| 8| 8| 8| 8| 5| 8| 8| 6| 0| 0| 9| 1| 2| 3| 9| 4| 9| 9| 0| 1| 0| 0| 0|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6|  |     A      |
    6 MG/M3                                | 2| 3| 5| 6| 9| 0| 1| 5| 1| 4| 5| 7| 9| 2| 3| 5| 1| 4| 5| 6| 7| 8| 2| 4|  |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  41        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Alveolar/Bronchiolar Adenoma         |                   X                                                      |          4 |
      Alveolar/Bronchiolar Carcinoma       |                   X                                                      |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                    X                     |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  46        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  43        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  46        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A   |  38        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  50                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 5| 4| 0| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 2| 4| 7| 5| 3| 3| 7| 3| 3| 5| 3| 3| 3|             
                                           | 4| 6| 8| 8| 8| 6| 6| 6| 5| 6| 6| 6| 4| 0| 8| 7| 7| 7| 2| 7| 7| 4| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|             
    18 MG/M3                               | 3| 4| 5| 6| 7| 9| 2| 3| 5| 1| 3| 4| 5| 7| 9| 1| 3| 4| 1| 2| 8| 9| 0| 1| 2|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  A  M  +  +  +  A  +  +  +  A  +  A  +  +  +  A  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  A  +  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  I  M  A  M  +  +  M  +  +  +  A  +  M  +  M  I  +  +  +  A  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  A  A  +  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  M  M  A  +  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  A  A  +  +  +  A  +  +  +  A  +  A  +  +  +  A  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  A  A  +  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                               X                                          |             
      Hepatocellular Carcinoma             |       X  X           X                       X              X  X  X      |             
      Hepatocellular Adenoma               |                X  X                                   X                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  M  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Spindle Cell, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Adenoma                              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | I  I  M  +  I  I  I  M  +  +  I  I  +  I  +  +  +  I  +  +  +  A  +  +  M|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  I  M  +  +  I  M  +  M  +  M  +  +  +  M  +  +  +  +  +  A  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                     +                                    |             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma, Metastatic, Spleen  |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 5| 4| 0| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 2| 4| 7| 5| 3| 3| 7| 3| 3| 5| 3| 3| 3|             
                                           | 4| 6| 8| 8| 8| 6| 6| 6| 5| 6| 6| 6| 4| 0| 8| 7| 7| 7| 2| 7| 7| 4| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|             
    18 MG/M3                               | 3| 4| 5| 6| 7| 9| 2| 3| 5| 1| 3| 4| 5| 7| 9| 1| 3| 4| 1| 2| 8| 9| 0| 1| 2|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                       +                    +                       +   |             
                                            __________________________________________________________________________|             
   Prostate                                | M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | I  +  +  M  M  +  +  M  I  M  M  M  +  M  M  +  +  M  M  I  M  M  +  M  +|             
      Hemangiosarcoma, Metastatic, Spleen  |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  M  M  M  M  M  M  M  M  M  M  +  M  M  M  +  M  +  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +|             
      Hemangiosarcoma, Metastatic, Spleen  |                                     X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hemangiosarcoma                      |                                     X                 X                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  M|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | I  M  +  M  I  M  M  M  M  M  M  M  M  M  +  M  +  M  M  I  M  M  +  +  I|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Spleen  |                                     X                                    |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
      Thoracic, Alveolar/Bronchiolar       |                                                                          |             
          Carcinoma, Metastatic, Lung      |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                X                                      X                  |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |    X                                                        X            |             
      Alveolar/Bronchiolar Carcinoma       |          X                                                               |             
      Hemangiosarcoma, Metastatic, Spleen  |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 5| 4| 0| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 2| 4| 7| 5| 3| 3| 7| 3| 3| 5| 3| 3| 3|             
                                           | 4| 6| 8| 8| 8| 6| 6| 6| 5| 6| 6| 6| 4| 0| 8| 7| 7| 7| 2| 7| 7| 4| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|             
    18 MG/M3                               | 3| 4| 5| 6| 7| 9| 2| 3| 5| 1| 3| 4| 5| 7| 9| 1| 3| 4| 1| 2| 8| 9| 0| 1| 2|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  I  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                               +  +   |             
      Adenoma                              |                   X                                               X  X   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 3| 2| 2| 5| 3| 2| 3| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 3| 3| 3| 2| 3|            |
                                           | 0| 0| 1| 8| 2| 1| 8| 8| 2| 8| 8| 5| 0| 8| 9| 0| 0| 9| 9| 9| 9| 9| 9| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     T      |
                               ANIMAL ID   | 5| 5| 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4|     A      |
    18 MG/M3                               | 3| 5| 7| 9| 1| 2| 3| 4| 5| 3| 4| 6| 7| 8| 0| 1| 3| 2| 3| 4| 7| 8| 9| 3| 5|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  I  A  +     +  M  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A  +     A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +     A  A  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +     A  A  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  M     A  A  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  +     A  A  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|  36        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +     A  A  +  A  +  +  +  +  +  A  +  +  +  +  +  +  M  +  A  +|  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +     A  A  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +     A  A  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|  36        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |       X  X        X                          X                           |         11 |
      Hepatocellular Adenoma               |                                              X                           |          4 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A  +     A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +     A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  43        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Spindle Cell, Adenoma                |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  M  +     +  +  M  A  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  A  M     A  A  M  A  M  +  +  I  I  +  I  +  +  +  +  +  I  M  +  +|  24        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  M     M  +  +  A  M  M  M  M  M  +  M  +  +  M  +  +  +  M  +  +|  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  A  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Follicular Cell, Adenoma             |    X                                               X                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                 +                        |   2        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  54                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 3| 2| 2| 5| 3| 2| 3| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 3| 3| 3| 2| 3|            |
                                           | 0| 0| 1| 8| 2| 1| 8| 8| 2| 8| 8| 5| 0| 8| 9| 0| 0| 9| 9| 9| 9| 9| 9| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     T      |
                               ANIMAL ID   | 5| 5| 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4|     A      |
    18 MG/M3                               | 3| 5| 7| 9| 1| 2| 3| 4| 5| 3| 4| 6| 7| 8| 0| 1| 3| 2| 3| 4| 7| 8| 9| 3| 5|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
      Hemangioma                           |                                                 X                        |          1 |
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     A  +  +  A  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M|  42        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                               +           +                    +  +      |   8        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  I  A  +     A  A  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     A  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  A  +     +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +     +  +  +  A  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|  44        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  M  +     M  M  M  A  M  M  +  M  +  +  M  +  +  M  +  M  M  +  +  M|  19        |
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  M  +     M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M|   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | I  +  +  +     A  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M|  40        |
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hemangiosarcoma                      |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +  +  I  +  +|  40        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  +     M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M|   8        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Thoracic, Alveolar/Bronchiolar       |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  55                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 3| 2| 2| 5| 3| 2| 3| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 3| 3| 3| 2| 3|            |
                                           | 0| 0| 1| 8| 2| 1| 8| 8| 2| 8| 8| 5| 0| 8| 9| 0| 0| 9| 9| 9| 9| 9| 9| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     T      |
                               ANIMAL ID   | 5| 5| 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4|     A      |
    18 MG/M3                               | 3| 5| 7| 9| 1| 2| 3| 4| 5| 3| 4| 6| 7| 8| 0| 1| 3| 2| 3| 4| 7| 8| 9| 3| 5|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +     A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Alveolar/Bronchiolar Adenoma         | X                             X              X                 X        X|          7 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                      X   |          2 |
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |       X           X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     A  M  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                  +                                       |   4        |
      Adenoma                              |                                  X                                       |          4 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  43        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  56                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 5| 1| 1| 1| 7| 7| 5| 3| 3| 3| 7| 3| 7| 2| 1| 7| 7| 3| 6| 1| 5|             
                             DAY ON TEST   | 3| 4| 1| 3| 4| 8| 8| 8| 3| 3| 4| 6| 6| 6| 3| 6| 3| 9| 8| 3| 3| 6| 1| 8| 4|             
                                           | 9| 9| 5| 9| 9| 5| 5| 5| 9| 9| 9| 9| 8| 9| 9| 8| 9| 5| 5| 9| 9| 9| 9| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 7| 9| 9| 9| 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 6| 6|             
    CONTROL                                | 2| 3| 5| 6| 8| 9| 3| 4| 7| 9| 0| 1| 4| 2| 8| 9| 0| 2| 3| 3| 6| 7| 9| 0| 1|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +           +     +           M     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +           +     +           +     I                       +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +           +     +           +     +                       +     +  +|             
      Hepatocellular Carcinoma             |    X                                                                    X|             
      Hepatocellular Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +           +     +           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +           +     +           +     +                       +     +  +|             
      Rhabdomyosarcoma, Metastatic,        |                                                                          |             
          Skeletal Muscle                  |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +           M     M           M     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +           +     M           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +           +     M           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                  +     +                       +         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Prostate                                |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +           M     M           +     +                       +     M  +|             
                                            __________________________________________________________________________|             
   Testes                                  |    +           +     +           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +           +     +           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 5| 1| 1| 1| 7| 7| 5| 3| 3| 3| 7| 3| 7| 2| 1| 7| 7| 3| 6| 1| 5|             
                             DAY ON TEST   | 3| 4| 1| 3| 4| 8| 8| 8| 3| 3| 4| 6| 6| 6| 3| 6| 3| 9| 8| 3| 3| 6| 1| 8| 4|             
                                           | 9| 9| 5| 9| 9| 5| 5| 5| 9| 9| 9| 9| 8| 9| 9| 8| 9| 5| 5| 9| 9| 9| 9| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 7| 9| 9| 9| 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 6| 6|             
    CONTROL                                | 2| 3| 5| 6| 8| 9| 3| 4| 7| 9| 0| 1| 4| 2| 8| 9| 0| 2| 3| 3| 6| 7| 9| 0| 1|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +           +     +           +     +                       +     +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +           +     M           +     +                       M     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +           +     +           M     M                       +     M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +           M     M           +     M                       M     +  +|             
      Adenocarcinoma, Metastatic, Lung     |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +           +     M           +     +                       +     M  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +           M     +           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +           +     M           M     M                       M     M  M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +           +     +           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                                     |             
      Rhabdomyosarcoma                     |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +           +     +           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Lung                                    |    +           +     +           +     +                       +     +  +|             
      Alveolar/Bronchiolar Carcinoma       |    X                                                                     |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic                       |    X                                                                     |             
      Hepatocellular Carcinoma, Metastatic |    X                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +           +     +           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +           +     +           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +           +     +           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 5| 1| 1| 5| 7| 0| 1| 7| 5| 5| 3| 7|                                |            |
                             DAY ON TEST   | 6| 6| 5| 8| 8| 4| 3| 3| 8| 3| 4| 5| 6| 3|                                |            |
                                           | 9| 9| 0| 6| 7| 9| 9| 9| 7| 9| 9| 0| 9| 9|                                |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |     O      |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|                                |     T      |
                               ANIMAL ID   | 6| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 2| 2|                                |     A      |
    CONTROL                                | 2| 1| 3| 6| 7| 0| 1| 5| 1| 4| 6| 9| 2| 4|                                |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +        +  +              +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +        +  +              M                                          |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +        +  +              +                                          |  12        |
      Hepatocellular Carcinoma             |                                                                          |          2 |
      Hepatocellular Adenoma               |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +        +  +              +                                          |  12        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +        +  +              +                                          |  12        |
      Rhabdomyosarcoma, Metastatic,        |                                                                          |            |
          Skeletal Muscle                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +        +  I              +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +        +  I              +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +        M  +              +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M        M  +              M                                          |   6        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +        +  +              +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +        +  +              +                                          |  11        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +                                                                     |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +        +  +              +                                          |  12        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 5| 1| 1| 5| 7| 0| 1| 7| 5| 5| 3| 7|                                |            |
                             DAY ON TEST   | 6| 6| 5| 8| 8| 4| 3| 3| 8| 3| 4| 5| 6| 3|                                |            |
                                           | 9| 9| 0| 6| 7| 9| 9| 9| 7| 9| 9| 0| 9| 9|                                |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |     O      |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|                                |     T      |
                               ANIMAL ID   | 6| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 2| 2|                                |     A      |
    CONTROL                                | 2| 1| 3| 6| 7| 0| 1| 5| 1| 4| 6| 9| 2| 4|                                |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +        M  +              +                                          |   8        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +        +  +              +                                          |  12        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +        +  +              +                                          |  12        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +        +  +              M                                          |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +  M              M                                          |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +        M  M              M                                          |   5        |
      Adenocarcinoma, Metastatic, Lung     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +        +  +              +                                          |  10        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +        +  +              +                                          |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M        M  M              +                                          |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +        +  +              +                                          |  12        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Rhabdomyosarcoma                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +        +  +              +                                          |  12        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +        +  +              +                                          |  12        |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +        +  +              +                                          |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 5| 1| 1| 5| 7| 0| 1| 7| 5| 5| 3| 7|                                |            |
                             DAY ON TEST   | 6| 6| 5| 8| 8| 4| 3| 3| 8| 3| 4| 5| 6| 3|                                |            |
                                           | 9| 9| 0| 6| 7| 9| 9| 9| 7| 9| 9| 0| 9| 9|                                |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |     O      |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|                                |     T      |
                               ANIMAL ID   | 6| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 2| 2|                                |     A      |
    CONTROL                                | 2| 1| 3| 6| 7| 0| 1| 5| 1| 4| 6| 9| 2| 4|                                |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +        +  +              +                                          |  12        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +        +  +              +                                          |  12        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 1| 7| 7| 1| 5| 3| 7| 3| 5| 1| 7| 5| 3| 1| 5| 3| 7| 5| 5| 3| 5| 7| 1|             
                             DAY ON TEST   | 7| 6| 8| 3| 3| 8| 4| 6| 3| 6| 4| 8| 3| 4| 6| 8| 4| 6| 3| 4| 5| 6| 4| 3| 8|             
                                           | 6| 9| 5| 9| 9| 5| 9| 8| 9| 9| 9| 5| 9| 9| 8| 5| 9| 9| 9| 9| 0| 9| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 7| 7| 9| 9| 9| 9| 0|             
    6 MG/M3                                | 2| 3| 6| 9| 1| 2| 3| 1| 4| 7| 9| 3| 4| 5| 2| 3| 7| 9| 0| 3| 1| 4| 7| 8| 2|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +           +        +     +     M           M     +        +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +           +        +     +     +           +     M        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +           +        +     +     +           +     M        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +           +        +     +     +           +     +        +     +|             
      Hepatocellular Adenoma               |                                                    X                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  M           M        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  M           M        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  M           M        +     +     M           +     +        +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    M  +           +        +     +     M           M     +        +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  M           +        M     M     M           M     M        +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +           +        M     +     +           I     +        M     +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                       +                       +                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  M           +        +     M     +           +     +        +     M|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    M  +           +        I     I     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    M  +           +        +     +     M           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 1| 7| 7| 1| 5| 3| 7| 3| 5| 1| 7| 5| 3| 1| 5| 3| 7| 5| 5| 3| 5| 7| 1|             
                             DAY ON TEST   | 7| 6| 8| 3| 3| 8| 4| 6| 3| 6| 4| 8| 3| 4| 6| 8| 4| 6| 3| 4| 5| 6| 4| 3| 8|             
                                           | 6| 9| 5| 9| 9| 5| 9| 8| 9| 9| 9| 5| 9| 9| 8| 5| 9| 9| 9| 9| 0| 9| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 7| 7| 9| 9| 9| 9| 0|             
    6 MG/M3                                | 2| 3| 6| 9| 1| 2| 3| 1| 4| 7| 9| 3| 4| 5| 2| 3| 7| 9| 0| 3| 1| 4| 7| 8| 2|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    M  M           +        M     M     +           M     M        +     M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +           +        +     M     M           +     +        +     M|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +           +        +     +     +           M     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  M           M        +     M     M           M     M        M     M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +           +        +     +     +           +     +        +     +|             
      Alveolar/Bronchiolar Adenoma         |                                                                   X      |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                   A      |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 1| 7| 3| 7| 5| 1| 5| 3| 6| 3| 7| 7| 1|                             |            |
                             DAY ON TEST   | 1| 7| 8| 3| 6| 3| 5| 8| 5| 6| 7| 7| 3| 1| 8|                             |            |
                                           | 7| 6| 6| 9| 9| 9| 0| 7| 4| 9| 2| 6| 9| 8| 7|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     T      |
                               ANIMAL ID   | 0| 0| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 6| 6| 6|                             |     A      |
    6 MG/M3                                | 3| 4| 2| 3| 6| 8| 0| 1| 4| 2| 3| 9| 1| 3| 5|                             |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +        +                                                   |  10        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |             +        +                                                   |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +        +                                                   |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   |             +        +                                                   |  12        |
      Hepatocellular Adenoma               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +        +                                                   |  12        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +        +                                                   |  12        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |             +        +                                                   |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |             +        +                                                   |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |             +        +                                                   |   9        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +        +                                                   |   9        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |             +        +                                                   |   6        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |             +        +                                                   |   9        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |             +        +                                                   |  12        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Prostate                                |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +        M                                                   |   8        |
                                            __________________________________________________________________________|____________|
   Testes                                  |             +        +                                                   |  12        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  64                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 1| 7| 3| 7| 5| 1| 5| 3| 6| 3| 7| 7| 1|                             |            |
                             DAY ON TEST   | 1| 7| 8| 3| 6| 3| 5| 8| 5| 6| 7| 7| 3| 1| 8|                             |            |
                                           | 7| 6| 6| 9| 9| 9| 0| 7| 4| 9| 2| 6| 9| 8| 7|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     T      |
                               ANIMAL ID   | 0| 0| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 6| 6| 6|                             |     A      |
    6 MG/M3                                | 3| 4| 2| 3| 6| 8| 0| 1| 4| 2| 3| 9| 1| 3| 5|                             |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |             +        +                                                   |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +        M                                                   |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |             +        M                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +        +                                                   |   9        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |             +        +                                                   |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +        M                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    |             +        +                                                   |  12        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +        +                                                   |  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +        +                                                   |  12        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Lung                                    |             +        +                                                   |  12        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +        +                                                   |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +        +                                                   |  12        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |             +        +                                                   |  12        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  65                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 5| 1| 1| 1| 7| 3| 5| 1| 3| 5| 1| 5| 5| 1| 7| 5| 7| 3| 1| 1| 1| 7| 5|             
                             DAY ON TEST   | 1| 4| 4| 1| 1| 8| 3| 6| 4| 8| 6| 4| 8| 6| 4| 8| 3| 5| 3| 6| 8| 4| 8| 3| 4|             
                                           | 3| 9| 9| 4| 4| 7| 9| 8| 9| 5| 8| 9| 5| 9| 9| 6| 9| 0| 9| 9| 6| 8| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 9| 9| 9| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 7| 7| 7|             
    18 MG/M3                               | 1| 2| 8| 0| 1| 4| 2| 6| 8| 0| 2| 5| 3| 4| 5| 6| 7| 4| 1| 2| 3| 4| 5| 6| 8|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +                             +     +  +           M  +           +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +                             +     +  +           +  +           M|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +                             +     +  +           +  +           +|             
      Hepatocellular Adenoma               |                                                          X               |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +                             +     +  +           +  +           +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +                             +     +  +           +  +           +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +                             +     +  +           M  +           +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  M                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +                             +     M  M           M  M           M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +                             M     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +                             +     +  +           M  +           +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                          +              +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +                             M     +  M           +  M           +|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +                             +     +  +           +  +           +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +  +                             +     +  +           M  +           +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  M                             +     M  M           M  M            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 5| 1| 1| 1| 7| 3| 5| 1| 3| 5| 1| 5| 5| 1| 7| 5| 7| 3| 1| 1| 1| 7| 5|             
                             DAY ON TEST   | 1| 4| 4| 1| 1| 8| 3| 6| 4| 8| 6| 4| 8| 6| 4| 8| 3| 5| 3| 6| 8| 4| 8| 3| 4|             
                                           | 3| 9| 9| 4| 4| 7| 9| 8| 9| 5| 8| 9| 5| 9| 9| 6| 9| 0| 9| 9| 6| 8| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 9| 9| 9| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 7| 7| 7|             
    18 MG/M3                               | 1| 2| 8| 0| 1| 4| 2| 6| 8| 0| 2| 5| 3| 4| 5| 6| 7| 4| 1| 2| 3| 4| 5| 6| 8|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    M  M                             M     +  M           +  M           M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  M                             +     +  +           +  +           M|             
                                            __________________________________________________________________________|             
   Spleen                                  |    M  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +                             +     +  +           +  +           +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M                             M     M  M           M  M           M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +                             +     +  +           +  +           +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +                             +     +  +           +  +           +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +                             +     +  +           +  +           +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +                             +     +  +           M  +           +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +                             +     +  +           +  +           +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +                             +     +  +           +  +           +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 1| 7| 3| 7| 5| 6| 5| 3| 2| 5| 1| 3| 3|                             |            |
                             DAY ON TEST   | 3| 6| 8| 3| 6| 3| 5| 4| 5| 6| 1| 9| 8| 6| 6|                             |            |
                                           | 9| 9| 7| 9| 9| 9| 0| 6| 0| 9| 5| 4| 6| 9| 9|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                             |     T      |
                               ANIMAL ID   | 8| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 4| 4| 4| 4|                             |     A      |
    18 MG/M3                               | 0| 1| 2| 5| 9| 2| 4| 5| 1| 5| 6| 0| 1| 2| 4|                             |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    M  +                    +           M                                 |   9        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    M  +                    +           +                                 |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +                    +           I                                 |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +                    +           +                                 |  12        |
      Hepatocellular Adenoma               |    X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +                    +           +                                 |  12        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +                    +           +                                 |  12        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +                    +           +                                 |  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  M                    +           +                                 |   9        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +                    +           +                                 |  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  M                    M           M                                 |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +                    +           +                                 |  11        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +                    +           +                                 |  11        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +                       +           +                                 |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +                       +           +                                 |   8        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +                    +           +                                 |  12        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  68                                                               
NTP Experiment-Test: 05079-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:42:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 1| 7| 3| 7| 5| 6| 5| 3| 2| 5| 1| 3| 3|                             |            |
                             DAY ON TEST   | 3| 6| 8| 3| 6| 3| 5| 4| 5| 6| 1| 9| 8| 6| 6|                             |            |
                                           | 9| 9| 7| 9| 9| 9| 0| 6| 0| 9| 5| 4| 6| 9| 9|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   B6C3F1 MICE MALE                        | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                             |     T      |
                               ANIMAL ID   | 8| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 4| 4| 4| 4|                             |     A      |
    18 MG/M3                               | 0| 1| 2| 5| 9| 2| 4| 5| 1| 5| 6| 0| 1| 2| 4|                             |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +  +                    M           +                                 |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  M                    M           +                                 |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    M  M                    +           M                                 |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +                    +           +                                 |  10        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +                    +           +                                 |  11        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +                    +           +                                 |  12        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M  M                    M           M                                 |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +                    +           +                                 |  12        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +                    +           +                                 |  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +                    +           +                                 |  12        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +                    M           +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +                    +           +                                 |  12        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +                    +           +                                 |  12        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  69                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.