National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2491

TDMS Study 05079-02 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                                TALC


NTP Experiment-Test: 05079-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:53




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  14807966

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05079-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTOL       CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           39           50           40           50           40           
  Scheduled Sacrifice                                              30                        30                        29           
  Early Deaths                                                                                                                      
    Natural Death                                     17            7           21            5           21           10           
    Moribund Sacrifice                                 2            2            4            5            4            1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                30                        23                        25                        
  Missing                                              1                         1                                                  
  Culled                                                                         1                                                  
  Animals Examined Microscopically                    46           11           49           12           50           12           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (43)         (11)         (48)         (11)         (48)         (10)         
   Gallbladder                                        (31)         (10)         (29)         (10)         (29)         (9)          
   Intestine Large, Cecum                             (35)         (11)         (30)         (12)         (34)         (12)         
      Leiomyoma                                                                                            1 (3%)                   
   Intestine Large, Colon                             (38)         (11)         (34)         (12)         (32)         (12)         
      Leiomyosarcoma                                                             1 (3%)                                             
   Intestine Small, Ileum                             (33)         (11)         (28)         (12)         (31)         (12)         
   Liver                                              (46)         (11)         (47)         (12)         (50)         (12)         
      Hemangioma                                                                 1 (2%)                                             
      Hepatocellular Carcinoma                         7 (15%)                   5 (11%)                   4 (8%)                   
      Hepatocellular Adenoma                           5 (11%)                   1 (2%)                    4 (8%)       1 (8%)      
   Mesentery                                          (2)                                                                           
   Pancreas                                           (42)         (11)         (40)         (11)         (44)         (12)         
   Salivary Glands                                    (46)         (11)         (49)         (12)         (50)         (12)         
      Hemangioma                                       1 (2%)                                                                       
   Stomach, Glandular                                 (45)         (10)         (40)         (12)         (46)         (12)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (46)         (11)         (49)         (11)         (50)         (12)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05079-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTOL       CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (46)         (11)         (46)         (12)         (50)         (12)         
      Spindle Cell, Adenoma                            1 (2%)                                                                       
   Adrenal Gland, Cortex                              (46)         (11)         (45)         (11)         (50)         (12)         
      Adenoma                                          1 (2%)                                                                       
   Adrenal Gland, Medulla                             (41)         (10)         (44)         (10)         (45)         (11)         
      Pheochromocytoma Malignant                       1 (2%)                                                                       
   Pituitary Gland                                    (42)         (10)         (43)         (8)          (48)         (12)         
      Adenoma                                          5 (12%)                   4 (9%)                    2 (4%)                   
      Carcinoma                                                                  2 (5%)                                             
   Thyroid Gland                                      (43)         (9)          (48)         (9)          (49)         (11)         
      Follicular Cell, Adenoma                         1 (2%)                    2 (4%)                    2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (4)          (3)          (1)          (4)          (2)          (4)          
      Fibrosarcoma                                     1 (25%)                                                                      
      Hemangioma                                       1 (25%)                                             1 (50%)                  
      Hemangiosarcoma                                                                                      1 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (38)         (11)         (43)         (11)         (46)         (12)         
      Adenocarcinoma, Metastatic, Uterus               1 (3%)                                                                       
      Adenoma                                          1 (3%)                    1 (2%)                                             
      Cystadenoma                                                                1 (2%)                                             
      Luteoma                                          2 (5%)                                                                       
   Uterus                                             (44)         (11)         (46)         (12)         (49)         (12)         
      Adenocarcinoma                                   1 (2%)                                                                       
      Carcinoma Adenosquamous                                                                              1 (2%)                   
      Endometrium, Polyp                                                                      1 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (41)         (11)         (44)         (12)         (45)         (11)         
   Lymph Node                                         (46)         (11)         (47)         (12)         (49)         (12)         
   Lymph Node, Bronchial                              (38)         (9)          (37)         (6)          (43)         (11)         
      Adenocarcinoma, Metastatic, Kidney                                         1 (3%)                                             
      Adenocarcinoma, Metastatic, Uterus               1 (3%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  3 (8%)                                             
   Lymph Node, Mandibular                             (35)         (7)          (38)         (11)         (36)         (11)         
   Lymph Node, Mediastinal                            (13)         (5)          (17)         (5)          (14)                      
      Adenocarcinoma, Metastatic, Kidney                                         1 (6%)                                             
                                                             Page   3                                                               
NTP Experiment-Test: 05079-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTOL       CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (6%)                                             
   Lymph Node, Mesenteric                             (35)         (11)         (32)         (11)         (37)         (10)         
   Spleen                                             (45)         (11)         (45)         (12)         (50)         (12)         
      Hemangiosarcoma                                                                                      1 (2%)                   
   Thymus                                             (40)         (11)         (41)         (12)         (41)         (12)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  2 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (41)         (10)         (45)         (12)         (48)         (12)         
      Fibrosarcoma                                                                                         1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (46)         (11)         (49)         (12)         (50)         (12)         
      Vertebra, Alveolar/Bronchiolar Carcinoma,                                                                                     
           Metastatic, Lung                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Spinal Cord                                                                                            (1)                       
      Thoracic, Ganglioneuroma                                                                             1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (46)         (11)         (49)         (12)         (50)         (12)         
      Adenocarcinoma, Metastatic, Kidney                                         1 (2%)                                             
      Alveolar/Bronchiolar Adenoma                     3 (7%)       1 (9%)       2 (4%)                    2 (4%)                   
      Alveolar/Bronchiolar Carcinoma                   2 (4%)                    4 (8%)                    1 (2%)                   
      Hemangiosarcoma, Metastatic, Tissue NOS                                                              1 (2%)                   
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)                    2 (4%)                                             
   Trachea                                            (40)         (11)         (37)         (11)         (45)         (12)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)                       (2)                       (1)                       
      Adenocarcinoma                                                                                       1 (100%)                 
      Adenoma                                          2 (100%)                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05079-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTOL       CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (46)         (11)         (47)         (12)         (50)         (12)         
      Adenocarcinoma                                                             1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Transitional Epithelium, Papilloma                                                                                1 (8%)      
   Urinary Bladder                                    (44)         (11)         (41)         (12)         (41)         (12)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(46)        *(11)        *(49)        *(12)        *(50)        *(12)         
      Lymphoma Malignant Histiocytic                                                                       1 (2%)                   
      Lymphoma Malignant Lymphocytic                   2 (4%)                    3 (6%)                    3 (6%)                   
      Lymphoma Malignant Mixed                         3 (7%)                    4 (8%)                    2 (4%)                   
      Lymphoma Malignant Undifferentiated Cell         2 (4%)                                              2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05079-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTOL       CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            31           1          26           1          21           1               
     Total Primary Neoplasms                           42           1          33           1          31           2               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 18           1           9           1          10           1               
     Total Benign Neoplasms                            23           1          13           1          13           2               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              19                      19                      15                           
     Total Malignant Neoplasms                         19                      20                      18                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                       5                       1                           
     Total Metastatic Neoplasm                          5                      13                       1                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05079-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          49           39           49           40           50           40           
  Scheduled Sacrifice                                              35                        33                        31           
  Early Deaths                                                                                                                      
    Natural Death                                     16            4           18            5           14            7           
    Moribund Sacrifice                                 1                         2            1            3            1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                30                        28                        32                        
  Missing                                              1                                                                            
  Animals Examined Microscopically                    46           12           47           12           49           12           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (31)         (12)         (29)         (11)         (35)         (11)         
   Intestine Large, Colon                             (36)         (12)         (38)         (12)         (39)         (12)         
   Intestine Small, Duodenum                          (32)         (12)         (30)         (12)         (34)         (12)         
   Intestine Small, Ileum                             (33)         (12)         (32)         (11)         (35)         (12)         
      Adenocarcinoma                                                             1 (3%)                                             
   Liver                                              (45)         (12)         (47)         (12)         (48)         (12)         
      Hemangiosarcoma                                  1 (2%)                                              1 (2%)                   
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)                                                                       
      Hepatocellular Carcinoma                         6 (13%)      2 (17%)      5 (11%)                  11 (23%)                  
      Hepatocellular Adenoma                           1 (2%)       1 (8%)       8 (17%)      1 (8%)       4 (8%)       2 (17%)     
      Hepatocellular Adenoma, Multiple                 2 (4%)                    1 (2%)                                             
   Pancreas                                           (42)         (12)         (39)         (12)         (42)         (12)         
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
   Salivary Glands                                    (45)         (12)         (46)         (12)         (47)         (12)         
   Stomach, Glandular                                 (39)         (12)         (43)         (12)         (43)         (12)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (45)         (12)         (46)         (12)         (49)         (12)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                                            1 (2%)                   
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle                 1 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05079-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (43)         (12)         (46)         (10)         (47)         (12)         
      Spindle Cell, Adenoma                            1 (2%)                    1 (2%)                    1 (2%)                   
   Adrenal Gland, Cortex                              (43)         (11)         (46)         (10)         (47)         (11)         
      Adenoma                                                                    1 (2%)                    1 (2%)                   
   Adrenal Gland, Medulla                             (39)         (11)         (39)         (9)          (42)         (9)          
      Pheochromocytoma Malignant                       1 (3%)                                                                       
   Pituitary Gland                                    (44)         (11)         (44)         (9)          (46)         (11)         
      Adenoma                                          1 (2%)                                                                       
      Pars Intermedia, Adenoma                                                   2 (5%)                                             
   Thyroid Gland                                      (45)         (11)         (46)         (12)         (45)         (11)         
      Follicular Cell, Adenoma                                                                             2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (4)          (3)          (4)          (2)          (5)          
      Hemangioma                                                                                           1 (50%)                  
      Hemangiosarcoma, Metastatic, Spleen                                                                  1 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (39)         (12)         (39)         (12)         (42)         (12)         
   Prostate                                           (40)         (12)         (43)         (12)         (44)         (12)         
   Seminal Vesicle                                    (41)         (8)          (43)         (8)          (39)         (8)          
   Testes                                             (43)         (12)         (44)         (12)         (45)         (12)         
      Hemangiosarcoma                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (40)         (12)         (42)         (12)         (43)         (12)         
      Hemangiosarcoma, Metastatic, Spleen              1 (3%)                                                                       
   Lymph Node                                         (45)         (12)         (46)         (12)         (48)         (12)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (8%)                                                          
   Lymph Node, Bronchial                              (32)         (9)          (39)         (9)          (44)         (10)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                                            1 (2%)                   
   Lymph Node, Mandibular                             (23)         (6)          (23)         (9)          (19)         (4)          
      Hemangiosarcoma, Metastatic, Spleen                                                                  1 (5%)                   
   Lymph Node, Mediastinal                            (9)          (5)          (10)         (4)          (7)          (3)          
      Adenocarcinoma, Metastatic, Lung                              1 (20%)                                                         
   Lymph Node, Mesenteric                             (36)         (10)         (39)         (9)          (40)         (10)         
      Hemangiosarcoma, Metastatic, Spleen                                                                  1 (3%)                   
   Spleen                                             (44)         (12)         (44)         (12)         (47)         (11)         
                                                             Page   8                                                               
NTP Experiment-Test: 05079-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Hemangiosarcoma                                  2 (5%)                                              2 (4%)                   
   Thymus                                             (34)         (11)         (33)         (11)         (40)         (12)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                                            1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (46)         (12)         (47)         (12)         (49)         (12)         
      Hemangiosarcoma, Metastatic, Spleen                                                                  1 (2%)                   
   Skeletal Muscle                                                 (1)                                    (1)                       
      Rhabdomyosarcoma                                              1 (100%)                                                        
      Thoracic, Alveolar/Bronchiolar Carcinoma,                                                                                     
           Metastatic, Lung                                                                                1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (45)         (12)         (47)         (12)         (48)         (12)         
      Alveolar/Bronchiolar Adenoma                     6 (13%)                   4 (9%)       1 (8%)       7 (15%)                  
      Alveolar/Bronchiolar Adenoma, Multiple                                                               2 (4%)                   
      Alveolar/Bronchiolar Carcinoma                   6 (13%)      1 (8%)       2 (4%)                    2 (4%)                   
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Metastatic                    1 (8%)                                                          
      Hemangiosarcoma, Metastatic, Liver               1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen                                                                  1 (2%)                   
      Hepatocellular Carcinoma, Metastatic                          1 (8%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                    2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)                                                 (4)                       
      Adenoma                                          1 (100%)                                            4 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05079-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (45)         (12)         (46)         (12)         (48)         (12)         
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
   Urinary Bladder                                    (43)         (12)         (38)         (12)         (43)         (12)         
      Sarcoma                                          1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(46)        *(12)        *(47)        *(12)        *(49)        *(12)         
      Lymphoma Malignant Lymphocytic                                             1 (2%)                                             
      Lymphoma Malignant Mixed                         2 (4%)                                                                       
      Lymphoma Malignant Undifferentiated Cell         3 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05079-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 17:21:53  
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         B6C3F1 MICE MALE                          CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            26           3          20           2          28           2               
     Total Primary Neoplasms                           36           5          26           2          38           2               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 11           1          16           2          18           2               
     Total Benign Neoplasms                            12           1          17           2          22           2               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20           2           8                      15                           
     Total Malignant Neoplasms                         24           4           9                      16                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           1           1                       4                           
     Total Metastatic Neoplasm                          5           5           1                      11                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.