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TDMS Study 05079-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                                TALC


NTP Experiment-Test: 05079-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:44




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  14807966

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05079-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           22           50           22           50           22           
  Scheduled Sacrifice                                              14                        18                        12           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                28            5           17            3           27            8           
    Natural Death                                     11            2           19            1           14            2           
  Survivors                                                                                                                         
    Terminal Sacrifice                                11            1           13                         9                        
  Missing                                                                        1                                                  
  Animals Examined Microscopically                    50           15           49           18           50           12           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (46)         (15)         (34)         (18)         (43)         (12)         
      Hemorrhage, Focal                                                          1 (3%)                                             
      Inflammation                                    11 (24%)                   1 (3%)                    6 (14%)                  
      Parasite Metazoan                                7 (15%)      2 (13%)      3 (9%)       6 (33%)      6 (14%)      4 (33%)     
      Ulcer                                            1 (2%)                    1 (3%)                    1 (2%)                   
   Intestine Large, Colon                             (48)         (15)         (41)         (18)         (45)         (12)         
      Inflammation                                                               1 (2%)                    2 (4%)                   
      Parasite Metazoan                                2 (4%)       2 (13%)      3 (7%)                    3 (7%)       1 (8%)      
   Intestine Large, Rectum                            (38)         (15)         (37)         (18)         (41)         (12)         
      Inflammation                                     4 (11%)                                                                      
      Parasite Metazoan                                2 (5%)                    1 (3%)                    1 (2%)                   
   Intestine Small, Duodenum                          (48)         (15)         (44)         (18)         (47)         (12)         
      Necrosis, Focal                                  1 (2%)                                                                       
   Intestine Small, Ileum                             (44)         (15)         (32)         (18)         (38)         (12)         
      Hyperplasia, Lymphoid                            2 (5%)                                                                       
   Liver                                              (50)         (15)         (48)         (18)         (50)         (12)         
      Atrophy                                                                    1 (2%)                    1 (2%)                   
      Basophilic Focus                                27 (54%)      2 (13%)     17 (35%)      4 (22%)     21 (42%)      2 (17%)     
      Clear Cell Focus                                 1 (2%)                    2 (4%)                    1 (2%)                   
      Cyst Multilocular                                1 (2%)                                                                       
      Degeneration, Cystic                                                       2 (4%)                    1 (2%)                   
      Eosinophilic Focus                               2 (4%)       2 (13%)      5 (10%)                   4 (8%)                   
      Fatty Change                                    18 (36%)      1 (7%)      18 (38%)      1 (6%)      14 (28%)                  
      Fibrosis, Focal                                                                                                   1 (8%)      
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia                                                   1 (7%)                                                          
      Infiltration Cellular, Mononuclear Cell                                                              1 (2%)                   
      Inflammation, Chronic                                         1 (7%)                    1 (6%)                    1 (8%)      
      Inflammation, Focal, Granulomatous              13 (26%)                   3 (6%)                    4 (8%)                   
      Inflammation, Focal, Necrotizing                                           1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05079-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Necrosis, Focal                                  5 (10%)                   1 (2%)                    2 (4%)                   
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Thrombosis                                                                                           1 (2%)                   
      Bile Duct, Hyperplasia                          36 (72%)      7 (47%)     38 (79%)      8 (44%)     36 (72%)      4 (33%)     
      Centrilobular, Atrophy                                                     2 (4%)                    6 (12%)                  
      Centrilobular, Degeneration                     10 (20%)                  14 (29%)                  10 (20%)                  
      Centrilobular, Necrosis                          2 (4%)                    2 (4%)                    2 (4%)                   
      Hepatocyte, Atrophy, Focal                                                                           1 (2%)                   
      Serosa, Thrombosis                                                         3 (6%)                                             
   Mesentery                                          (1)                       (2)                                                 
      Granuloma                                        1 (100%)                  1 (50%)                                            
      Inflammation, Chronic Active                                               1 (50%)                                            
   Pancreas                                           (50)         (15)         (46)         (18)         (49)         (12)         
      Hyperplasia, Nodular                             1 (2%)                                                                       
      Inflammation                                                               1 (2%)       1 (6%)                                
      Lobules, Atrophy                                 7 (14%)      1 (7%)       7 (15%)                   9 (18%)                  
   Salivary Glands                                    (50)         (15)         (48)         (18)         (50)         (12)         
      Inflammation                                     2 (4%)                                                                       
   Stomach, Forestomach                               (50)         (15)         (45)         (17)         (49)         (12)         
      Hyperkeratosis                                   1 (2%)                                              1 (2%)                   
      Hyperplasia, Squamous                                                                   1 (6%)                                
      Inflammation                                     1 (2%)                                              2 (4%)                   
      Mineralization                                                             1 (2%)                                             
      Ulcer                                            9 (18%)                   4 (9%)                    3 (6%)                   
   Stomach, Glandular                                 (50)         (15)         (47)         (17)         (50)         (12)         
      Erosion                                                                                              1 (2%)                   
      Inflammation                                     1 (2%)                    1 (2%)                                             
      Mineralization                                   2 (4%)                    2 (4%)                    2 (4%)                   
      Ulcer                                            3 (6%)                    2 (4%)                    3 (6%)                   
      Ulcer, Multiple                                  1 (2%)                                              1 (2%)                   
      Arteriole, Muscularis, Lamina Propria,                                                                                        
          Mineralization                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (3)                       (3)                       (1)                       
      Aorta, Mineralization                                                      3 (100%)                  1 (100%)                 
      Mesenteric Artery, Aneurysm                      1 (33%)                                                                      
      Mesenteric Artery, Inflammation                  3 (100%)                                                                     
      Mesenteric Artery, Mineralization                                          1 (33%)                   1 (100%)                 
      Mesenteric Artery, Thrombosis                    1 (33%)                   1 (33%)                                            
   Heart                                              (50)         (15)         (48)         (18)         (50)         (12)         
      Cardiomyopathy                                  35 (70%)      6 (40%)     40 (83%)      8 (44%)     36 (72%)      3 (25%)     
      Inflammation, Focal                              1 (2%)                                              1 (2%)                   
      Atrium, Thrombosis                               5 (10%)                   8 (17%)                   5 (10%)                  
      Myocardium, Embolus                                                        2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05079-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Myocardium, Inflammation, Focal                                            1 (2%)                                             
      Myocardium, Mineralization                       1 (2%)                    4 (8%)                    3 (6%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (14)         (47)         (16)         (49)         (12)         
      Congestion                                                    1 (7%)                    1 (6%)                                
      Degeneration, Cystic                             1 (2%)       1 (7%)                                                          
      Degeneration, Fatty                              3 (6%)                                 1 (6%)                                
      Degeneration, Focal                              1 (2%)                    1 (2%)                                             
      Hyperplasia, Diffuse                                                       1 (2%)                    1 (2%)                   
      Hyperplasia, Focal                               9 (18%)                  12 (26%)                  13 (27%)                  
      Necrosis                                                                                             2 (4%)                   
      Necrosis, Focal                                  1 (2%)                    1 (2%)                                             
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Vacuolization Cytoplasmic                                     1 (7%)                                                          
   Adrenal Gland, Medulla                             (48)         (14)         (47)         (18)         (49)         (11)         
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                     20 (42%)      3 (21%)     18 (38%)      1 (6%)      14 (29%)      1 (9%)      
      Bilateral, Hyperplasia                           2 (4%)                    2 (4%)                    2 (4%)                   
   Parathyroid Gland                                  (43)         (12)         (42)         (15)         (47)         (8)          
      Cyst                                                                                    1 (7%)                                
      Hyperplasia                                      3 (7%)                    4 (10%)                   2 (4%)                   
      Bilateral, Hyperplasia                           1 (2%)                                                                       
   Pituitary Gland                                    (50)         (15)         (47)         (18)         (50)         (12)         
      Cyst                                             2 (4%)                                 1 (6%)       1 (2%)                   
      Pars Distalis, Hyperplasia                      10 (20%)                   6 (13%)                   4 (8%)       1 (8%)      
      Pars Distalis, Necrosis                                                                              1 (2%)                   
   Thyroid Gland                                      (50)         (13)         (47)         (18)         (49)         (11)         
      C-Cell, Hyperplasia                             10 (20%)      4 (31%)      8 (17%)      2 (11%)      4 (8%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (15)         (44)         (16)         (46)         (12)         
      Fibrosis                                                                                1 (6%)                                
      Hyperplasia                                      2 (4%)                                              1 (2%)                   
      Inflammation                                     1 (2%)                    1 (2%)                    1 (2%)                   
   Ovary                                              (50)         (15)         (47)         (18)         (50)         (12)         
      Cyst                                             5 (10%)      1 (7%)                                 1 (2%)                   
   Uterus                                             (50)         (15)         (48)         (18)         (50)         (12)         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05079-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                             1 (2%)                    1 (2%)                    1 (2%)                   
      Hyperplasia, Cystic                                                                     1 (6%)                                
      Inflammation                                     1 (2%)                    1 (2%)                                             
      Endometrium, Hyperplasia                         3 (6%)                                                                       
      Lamina Propria, Fibrosis                        20 (40%)                  39 (81%)                  19 (38%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (15)         (43)         (18)         (49)         (12)         
      Atrophy                                          1 (2%)                    2 (5%)                    1 (2%)                   
      Hyperplasia, Histiocytic                         1 (2%)       1 (7%)                    2 (11%)      1 (2%)       2 (17%)     
      Inflammation, Focal, Granulomatous               1 (2%)                                                                       
      Myelofibrosis                                    1 (2%)                    3 (7%)                    3 (6%)                   
      Necrosis, Focal                                                            1 (2%)                                             
      Femoral, Hyperplasia, Histiocytic                                                       1 (6%)                                
      Myeloid Cell, Hyperplasia                        2 (4%)                    2 (5%)       1 (6%)       3 (6%)       1 (8%)      
   Lymph Node                                         (50)         (15)         (48)         (18)         (50)         (12)         
      Axillary, Hemorrhage, Chronic                                                                        1 (2%)                   
      Renal, Hyperplasia, Histiocytic                                                         1 (6%)                                
   Lymph Node, Bronchial                              (46)         (10)         (47)         (18)         (47)         (9)          
      Cyst                                             1 (2%)                                                                       
      Fibrosis                                                                   1 (2%)                                             
      Hemorrhage, Chronic                                                        1 (2%)                                             
      Hyperplasia, Histiocytic                                                  40 (85%)     18 (100%)    45 (96%)      8 (89%)     
      Hyperplasia, Lymphoid                                         1 (10%)                                                         
      Inflammation, Suppurative                        1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)       1 (10%)                                                         
   Lymph Node, Mandibular                             (47)         (9)          (46)         (14)         (47)         (11)         
      Congestion                                                                                                        1 (9%)      
      Hyperplasia, Lymphoid                                                      1 (2%)       2 (14%)      1 (2%)       1 (9%)      
      Hyperplasia, Plasma Cell                         2 (4%)                    1 (2%)                    1 (2%)                   
      Inflammation, Chronic Active                     1 (2%)                                              1 (2%)                   
      Inflammation, Suppurative                                                                            1 (2%)                   
   Lymph Node, Mediastinal                            (47)         (11)         (44)         (17)         (47)         (12)         
      Congestion                                                    2 (18%)                   1 (6%)                    1 (8%)      
      Hemorrhage, Chronic                              1 (2%)                                                                       
      Hyperplasia, Histiocytic                                                  33 (75%)     14 (82%)     40 (85%)      9 (75%)     
      Hyperplasia, Lymphoid                            1 (2%)                                              1 (2%)                   
      Inflammation, Chronic Active                                                                         1 (2%)                   
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
      Pigmentation, Hemosiderin                                     2 (18%)                                                         
   Lymph Node, Mesenteric                             (49)         (14)         (47)         (18)         (47)         (12)         
      Edema                                                                                   1 (6%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Histiocytic                                      1 (7%)                    1 (6%)                                
      Hyperplasia, Lymphoid                            2 (4%)                    1 (2%)       1 (6%)       2 (4%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05079-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
      Inflammation, Chronic Active                     4 (8%)                    1 (2%)                                             
      Inflammation, Granulomatous                                                                          1 (2%)                   
   Spleen                                             (50)         (15)         (48)         (18)         (50)         (12)         
      Atrophy                                          2 (4%)                    2 (4%)                    2 (4%)                   
      Fibrosis, Focal                                  3 (6%)                    1 (2%)                    1 (2%)                   
      Hematopoietic Cell Proliferation                 4 (8%)                    6 (13%)      1 (6%)       7 (14%)                  
      Hyperplasia, Lymphoid                                                                                1 (2%)                   
      Inflammation, Focal, Granulomatous               1 (2%)                                                                       
      Pigmentation, Hemosiderin                        2 (4%)                                                                       
      Capsule, Hemorrhage                                                                                  1 (2%)                   
   Thymus                                             (47)         (14)         (44)         (15)         (47)         (12)         
      Cyst                                                                                    1 (7%)                                
      Inflammation                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (15)         (48)         (18)         (50)         (12)         
      Galactocele                                                                1 (2%)                                             
      Hyperplasia, Cystic                                           2 (13%)      2 (4%)       1 (6%)                                
      Lobules, Hyperplasia                                          2 (13%)                                1 (2%)                   
   Skin                                               (50)         (15)         (49)         (18)         (50)         (12)         
      Inflammation, Focal                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (15)         (48)         (18)         (50)         (12)         
      Fibrous Osteodystrophy                           4 (8%)                    3 (6%)                    4 (8%)                   
      Hyperostosis                                     4 (8%)                    1 (2%)                    3 (6%)                   
      Femur, Hyperplasia                                            1 (7%)                                                          
      Pelvis, Fracture                                 1 (2%)                                                                       
      Vertebra, Cyst                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (15)         (48)         (18)         (50)         (12)         
      Compression                                      8 (16%)      1 (7%)       7 (15%)                   9 (18%)                  
      Hemorrhage                                                                 1 (2%)                    1 (2%)                   
      Hydrocephalus                                                                                        1 (2%)                   
      Inflammation, Focal                                                        1 (2%)                                             
      White Matter, Necrosis, Focal                                                                        2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05079-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (15)         (48)         (18)         (48)         (12)         
      Inflammation, Necrotizing                                                                            1 (2%)                   
      Inflammation, Suppurative                        2 (4%)                    1 (2%)                    1 (2%)                   
   Lung                                               (50)         (15)         (48)         (18)         (50)         (12)         
      Crystals, Focal                                  1 (2%)                                                                       
      Cyst                                                                       1 (2%)                    5 (10%)                  
      Cyst, Multiple                                                                                       2 (4%)                   
      Edema                                            1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                    1 (2%)                   
      Hyperplasia, Diffuse, Adenomatous                                                                    2 (4%)                   
      Inflammation, Chronic Active                                  1 (7%)                                                          
      Inflammation, Granulomatous                      2 (4%)       1 (7%)      47 (98%)     18 (100%)    50 (100%)    12 (100%)    
      Inflammation, Suppurative                        2 (4%)                    1 (2%)                                             
      Mineralization                                                             2 (4%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (4%)       2 (13%)     27 (56%)     16 (89%)     47 (94%)     10 (83%)     
      Alveolus, Metaplasia, Squamous                                                                       8 (16%)                  
      Bronchus, Epithelium, Degeneration, Focal        1 (2%)                                                                       
      Interstitium, Fibrosis                                                                               1 (2%)                   
      Interstitium, Fibrosis, Focal                    1 (2%)                   24 (50%)     13 (72%)     44 (88%)      9 (75%)     
      Interstitium, Mineralization                                               1 (2%)                    1 (2%)                   
      Peribronchial, Hyperplasia, Histiocytic                                    8 (17%)      5 (28%)      9 (18%)      6 (50%)     
   Nose                                               (48)         (15)         (45)         (18)         (48)         (12)         
      Inflammation, Suppurative                                                  1 (2%)                                             
      Lumen, Foreign Body                                                                                  1 (2%)                   
      Mucosa, Inflammation, Suppurative                                          3 (7%)                    5 (10%)                  
      Nasolacrimal Duct, Inflammation, Suppurative     1 (2%)                                                                       
      Nerve, Developmental Malformation                1 (2%)                                                                       
      Olfactory Epithelium, Metaplasia                                           1 (2%)                                             
      Respiratory Epithelium, Hyperplasia              1 (2%)                    1 (2%)                    2 (4%)                   
      Respiratory Epithelium, Metaplasia, Squamous                               1 (2%)                                             
   Trachea                                            (50)         (15)         (48)         (18)         (50)         (12)         
      Inflammation, Necrotizing                                                                            1 (2%)                   
      Inflammation, Suppurative                        3 (6%)                    1 (2%)                    2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                                                 (2)                       
      Cataract                                         2 (100%)                                            2 (100%)                 
      Retina, Degeneration                             2 (100%)                                            2 (100%)                 
   Harderian Gland                                    (5)                       (7)          (1)          (15)                      
      Inflammation                                     4 (80%)                   3 (43%)                   3 (20%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05079-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (15)         (47)         (18)         (49)         (12)         
      Abscess                                          1 (2%)                                                                       
      Cyst                                                                       1 (2%)                    1 (2%)                   
      Cyst, Multiple                                   1 (2%)                                                                       
      Embolus, Multiple                                                          1 (2%)                                             
      Infarct                                          1 (2%)                                                                       
      Infarct, Multiple                                                                                    1 (2%)                   
      Inflammation                                     1 (2%)                    1 (2%)                                             
      Nephropathy                                     44 (90%)      9 (60%)     43 (91%)     12 (67%)     42 (86%)      6 (50%)     
      Capsule, Inflammation                                                      1 (2%)                                             
      Medulla, Inflammation                                                      1 (2%)                    1 (2%)                   
      Renal Tubule, Necrosis                           1 (2%)                                              2 (4%)                   
   Urinary Bladder                                    (50)         (15)         (45)         (18)         (50)         (12)         
      Inflammation                                                                                         1 (2%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05079-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           22           50           22           50           22           
  Scheduled Sacrifice                                              11                        15                        10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23            9           19            5           20            6           
    Natural Death                                     18            2           17            2           14            6           
  Survivors                                                                                                                         
    Terminal Sacrifice                                                           1                                                  
    Terminal Sacrifice                                 8                        11                        13                        
    Natural Death                                      1                         2                         3                        
  Animals Examined Microscopically                    49           11           50           15           50           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (10)         (50)         (10)         (49)         (9)          
      Inflammation                                                                                         1 (2%)                   
   Intestine Large, Cecum                             (42)         (11)         (38)         (15)         (37)         (10)         
      Hemorrhage                                                                 1 (3%)                                             
      Inflammation                                     9 (21%)                   2 (5%)                    5 (14%)                  
      Parasite Metazoan                                3 (7%)       4 (36%)      4 (11%)      6 (40%)      4 (11%)      4 (40%)     
      Ulcer                                            1 (2%)                                                                       
   Intestine Large, Colon                             (43)         (11)         (43)         (15)         (46)         (10)         
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation                                     1 (2%)                                              1 (2%)                   
      Mineralization                                                                                       1 (2%)                   
      Parasite Metazoan                                2 (5%)       1 (9%)       1 (2%)       1 (7%)       1 (2%)                   
   Intestine Large, Rectum                            (38)         (11)         (41)         (15)         (34)         (10)         
      Inflammation                                     6 (16%)                   1 (2%)                    1 (3%)                   
      Metaplasia, Focal, Squamous                                                                          1 (3%)                   
      Parasite Metazoan                                             1 (9%)       2 (5%)                                             
   Intestine Small, Duodenum                          (48)         (11)         (44)         (15)         (46)         (10)         
      Inflammation                                                                                         1 (2%)                   
      Mineralization                                   1 (2%)                                                                       
      Necrosis, Focal                                  1 (2%)                                                                       
      Ulcer                                            1 (2%)                    1 (2%)                                             
   Intestine Small, Ileum                             (39)         (11)         (34)         (15)         (35)         (10)         
      Hyperplasia, Lymphoid                                                      1 (3%)                    2 (6%)                   
      Lymphatic, Ectasia                                                         1 (3%)                                             
      Peyer's Patch, Hyperplasia, Focal, Lymphoid                                             1 (7%)                                
   Liver                                              (49)         (11)         (50)         (15)         (48)         (10)         
      Angiectasis, Focal                               1 (2%)                                                                       
      Atrophy                                          1 (2%)                                                                       
      Basophilic Focus                                18 (37%)      2 (18%)     18 (36%)      4 (27%)     19 (40%)      4 (40%)     
      Clear Cell Focus                                 3 (6%)                    7 (14%)                   4 (8%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05079-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Congestion                                                                 1 (2%)                                 1 (10%)     
      Degeneration, Cystic                             9 (18%)                  17 (34%)                   9 (19%)                  
      Degeneration, Diffuse                                                                                1 (2%)                   
      Eosinophilic Focus                               2 (4%)                    7 (14%)                   7 (15%)                  
      Fatty Change                                    16 (33%)      1 (9%)      14 (28%)                  12 (25%)                  
      Fibrosis                                         1 (2%)                                                                       
      Hematocyst                                                                 1 (2%)                                             
      Hyperplasia, Focal                                            1 (9%)                                 1 (2%)                   
      Inflammation, Focal, Granulomatous               3 (6%)                    1 (2%)                                             
      Inflammation, Focal, Necrotizing                                                                     1 (2%)                   
      Inflammation, Focal, Subacute                                                           1 (7%)                                
      Necrosis, Coagulative, Multifocal                             1 (9%)                                                          
      Necrosis, Focal                                  3 (6%)                                              1 (2%)                   
      Thrombosis                                       1 (2%)       1 (9%)                                                          
      Bile Duct, Hyperplasia                          39 (80%)      5 (45%)     46 (92%)      9 (60%)     44 (92%)      3 (30%)     
      Centrilobular, Atrophy                           9 (18%)                   4 (8%)                    7 (15%)                  
      Centrilobular, Degeneration                      8 (16%)                  12 (24%)                   9 (19%)                  
      Centrilobular, Degeneration, Fatty                                                                   1 (2%)                   
      Centrilobular, Necrosis                          5 (10%)                                             2 (4%)                   
   Mesentery                                          (2)                                                 (1)                       
      Inflammation                                                                                         1 (100%)                 
   Pancreas                                           (48)         (11)         (46)         (15)         (47)         (10)         
      Lobules, Atrophy                                11 (23%)                   7 (15%)                   8 (17%)                  
   Salivary Glands                                    (49)         (11)         (50)         (15)         (50)         (10)         
      Inflammation                                     1 (2%)                                                                       
      Necrosis                                                                                             1 (2%)                   
   Stomach, Forestomach                               (49)         (10)         (47)         (15)         (47)         (10)         
      Hyperkeratosis                                                                                       1 (2%)                   
      Inflammation                                     1 (2%)                                                                       
      Mineralization                                   1 (2%)                    4 (9%)                    1 (2%)                   
      Ulcer                                            5 (10%)                   5 (11%)                   8 (17%)                  
   Stomach, Glandular                                 (49)         (10)         (47)         (15)         (47)         (10)         
      Mineralization                                   6 (12%)                   6 (13%)                   6 (13%)                  
      Ulcer                                            3 (6%)                    3 (6%)                    2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (4)                       (5)                       (5)                       
      Aorta, Mineralization                            3 (75%)                   5 (100%)                  4 (80%)                  
      Mesenteric Artery, Aneurysm                                                                          2 (40%)                  
      Mesenteric Artery, Inflammation                                                                      1 (20%)                  
      Mesenteric Artery, Mineralization                3 (75%)                   5 (100%)                  3 (60%)                  
      Mesenteric Artery, Thrombosis                    1 (25%)                   1 (20%)                   1 (20%)                  
   Heart                                              (49)         (11)         (50)         (15)         (50)         (10)         
      Cardiomyopathy                                  42 (86%)      6 (55%)     47 (94%)      8 (53%)     50 (100%)     3 (30%)     
      Atrium, Thrombosis                               9 (18%)                   5 (10%)                  11 (22%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05079-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Epicardium, Hyperplasia                          1 (2%)                                                                       
      Myocardium, Inflammation                                                   1 (2%)                                             
      Myocardium, Mineralization                       2 (4%)                    6 (12%)                   5 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (11)         (49)         (15)         (48)         (10)         
      Degeneration                                     1 (2%)                                                                       
      Degeneration, Fatty                              8 (16%)                                             2 (4%)                   
      Degeneration, Focal                              1 (2%)                                                                       
      Hyperplasia, Diffuse                                                                                 2 (4%)                   
      Hyperplasia, Focal                              11 (22%)                   4 (8%)       1 (7%)       9 (19%)                  
      Necrosis, Focal                                  1 (2%)                                                                       
   Adrenal Gland, Medulla                             (49)         (10)         (48)         (15)         (47)         (10)         
      Hyperplasia                                     19 (39%)      1 (10%)      8 (17%)      3 (20%)      8 (17%)                  
      Bilateral, Hyperplasia                           1 (2%)       1 (10%)                                1 (2%)                   
   Islets, Pancreatic                                 (47)         (9)          (41)         (15)         (43)         (10)         
      Hyperplasia                                                                             1 (7%)       1 (2%)                   
   Parathyroid Gland                                  (45)         (6)          (45)         (7)          (46)         (8)          
      Hyperplasia                                      6 (13%)      1 (17%)     11 (24%)                  12 (26%)                  
      Bilateral, Hyperplasia                           1 (2%)                                                                       
   Pituitary Gland                                    (47)         (11)         (50)         (14)         (49)         (10)         
      Angiectasis, Focal                                                         1 (2%)                                             
      Cyst                                                                       1 (2%)       1 (7%)       1 (2%)       1 (10%)     
      Pars Distalis, Hyperplasia                       8 (17%)      1 (9%)       8 (16%)                   7 (14%)                  
      Pars Nervosa, Hyperplasia                                                  1 (2%)                                             
   Thyroid Gland                                      (45)         (11)         (46)         (13)         (46)         (8)          
      C-Cell, Hyperplasia                              5 (11%)      1 (9%)       7 (15%)      2 (15%)      2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (9)          (50)         (15)         (49)         (10)         
      Spermatocele                                                               1 (2%)                                             
   Preputial Gland                                    (48)         (11)         (49)         (15)         (48)         (8)          
      Hyperplasia                                      3 (6%)                                              1 (2%)                   
      Inflammation                                     7 (15%)                   2 (4%)                    5 (10%)                  
   Prostate                                           (49)         (10)         (45)         (15)         (48)         (10)         
      Atrophy                                          1 (2%)                                              1 (2%)                   
      Inflammation                                    22 (45%)      1 (10%)     14 (31%)      1 (7%)      19 (40%)      1 (10%)     
   Seminal Vesicle                                    (49)         (11)         (48)         (15)         (47)         (10)         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05079-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Atrophy                                          1 (2%)                                                                       
      Inflammation                                     1 (2%)                                                                       
   Testes                                             (49)         (11)         (50)         (15)         (50)         (10)         
      Atrophy                                         14 (29%)                  11 (22%)      1 (7%)      16 (32%)      1 (10%)     
      Cyst                                                          1 (9%)                                                          
      Hyperplasia, Focal, Lymphoid                                                                         1 (2%)                   
      Hyperplasia, Lymphoid                                                      2 (4%)                                             
      Interstitial Cell, Hyperplasia                   2 (4%)                    1 (2%)       1 (7%)       3 (6%)                   
      Serosa, Proliferation                                                                                1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (11)         (48)         (15)         (47)         (10)         
      Atrophy                                                                                              2 (4%)                   
      Atrophy, Focal                                                             1 (2%)                                             
      Hyperplasia, Histiocytic                                                                2 (13%)                               
      Inflammation                                                               1 (2%)                                             
      Myelofibrosis                                                              1 (2%)                    1 (2%)                   
      Myeloid Cell, Hyperplasia                        2 (4%)       1 (9%)       3 (6%)                    6 (13%)                  
   Lymph Node                                         (49)         (11)         (50)         (15)         (50)         (10)         
      Hemorrhage, Chronic                                                        1 (2%)                                             
      Pancreatic, Atrophy                              1 (2%)                                                                       
      Pancreatic, Hyperplasia, Lymphoid                1 (2%)                                                                       
   Lymph Node, Bronchial                              (41)         (9)          (48)         (15)         (49)         (10)         
      Atrophy                                          2 (5%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Hemorrhage, Acute                                1 (2%)                                                                       
      Hemorrhage, Chronic                              4 (10%)                                                                      
      Hyperplasia, Histiocytic                                                  44 (92%)     12 (80%)     46 (94%)     10 (100%)    
   Lymph Node, Mandibular                             (46)         (10)         (48)         (12)         (47)         (9)          
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                                         1 (10%)      2 (4%)       1 (8%)                    1 (11%)     
      Hyperplasia, Plasma Cell                                                   2 (4%)                    5 (11%)                  
      Inflammation, Chronic Active                                                                         2 (4%)                   
   Lymph Node, Mediastinal                            (48)         (11)         (49)         (11)         (47)         (10)         
      Atrophy                                          1 (2%)                                                                       
      Congestion                                                    1 (9%)                                              1 (10%)     
      Hemorrhage                                                                 3 (6%)                                             
      Hemorrhage, Acute                                1 (2%)                                                                       
      Hemorrhage, Chronic                              6 (13%)                                                                      
      Hyperplasia, Histiocytic                                                  40 (82%)      8 (73%)     43 (91%)      7 (70%)     
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
   Lymph Node, Mesenteric                             (49)         (10)         (48)         (15)         (47)         (10)         
      Atrophy                                          1 (2%)                                                                       
      Depletion Lymphoid                                            1 (10%)                                                         
      Hemorrhage                                                                 2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05079-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage, Acute                                1 (2%)                                                                       
      Hyperplasia, Histiocytic                                                                2 (13%)                               
      Hyperplasia, Lymphoid                            1 (2%)       2 (20%)      2 (4%)                    3 (6%)                   
      Hyperplasia, Plasma Cell                                                                             1 (2%)                   
      Inflammation, Chronic Active                                                                         1 (2%)                   
   Spleen                                             (49)         (11)         (50)         (15)         (48)         (10)         
      Atrophy                                          1 (2%)                                              2 (4%)       1 (10%)     
      Autolysis                                                                                            1 (2%)                   
      Congestion, Acute                                             1 (9%)                                                          
      Congestion, Chronic                              1 (2%)                                                                       
      Cyst                                                                                                 1 (2%)                   
      Fibrosis                                                                   1 (2%)                                             
      Fibrosis, Focal                                                            5 (10%)                   2 (4%)                   
      Hematopoietic Cell Proliferation                 1 (2%)                    2 (4%)                    3 (6%)                   
      Hyperplasia, Histiocytic                                                   1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                    1 (2%)                   
      Infarct                                          3 (6%)                                 1 (7%)                                
      Inflammation, Focal, Granulomatous               1 (2%)                                              1 (2%)                   
   Thymus                                             (48)         (11)         (40)         (13)         (43)         (9)          
      Atrophy                                                       1 (9%)       2 (5%)                                             
      Cyst                                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (10)         (48)         (11)         (50)         (9)          
      Galactocele                                      1 (2%)                                                                       
      Hyperplasia, Cystic                                                                     1 (9%)                                
      Lobules, Hyperplasia                                                                                              1 (11%)     
   Skin                                               (48)         (11)         (50)         (15)         (50)         (10)         
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Subcutaneous Tissue, Inflammation                                                                    1 (2%)                   
      Tail, Necrosis                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (11)         (50)         (15)         (50)         (10)         
      Fibrous Osteodystrophy                           3 (6%)                    4 (8%)                    5 (10%)                  
      Coccygeal, Necrosis                              1 (2%)                                                                       
      Pelvis, Fracture                                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05079-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (11)         (50)         (15)         (50)         (10)         
      Compression                                      5 (10%)                   2 (4%)                    2 (4%)                   
      Hemorrhage                                                                 1 (2%)                                             
      Infarct                                                                                              1 (2%)                   
      Necrosis, Focal                                  1 (2%)                    2 (4%)                                             
   Spinal Cord                                                                                            (1)                       
      Degeneration                                                                                         1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (48)         (11)         (49)         (15)         (49)         (10)         
      Inflammation, Suppurative                        6 (13%)                                                                      
   Lung                                               (49)         (11)         (50)         (15)         (50)         (10)         
      Congestion                                       1 (2%)                                                                       
      Crystals, Focal                                  1 (2%)                                                                       
      Cyst                                                                                                 3 (6%)                   
      Hemorrhage, Chronic                              2 (4%)                                                                       
      Infarct                                          1 (2%)                                                                       
      Inflammation, Granulomatous                      2 (4%)       1 (9%)      50 (100%)    15 (100%)    49 (98%)     10 (100%)    
      Inflammation, Suppurative                                                  2 (4%)                                             
      Mineralization                                                             4 (8%)                                             
      Alveolar Epithelium, Hyperplasia                 5 (10%)      1 (9%)      26 (52%)     12 (80%)     38 (76%)      7 (70%)     
      Alveolus, Hemorrhage, Focal                      1 (2%)                                                                       
      Alveolus, Metaplasia, Squamous                                                                       2 (4%)                   
      Artery, Thrombosis                               1 (2%)                                                                       
      Interstitium, Fibrosis, Focal                    1 (2%)                   16 (32%)     10 (67%)     33 (66%)      7 (70%)     
      Interstitium, Mineralization                     2 (4%)                    1 (2%)                    4 (8%)                   
      Peribronchial, Hyperplasia, Histiocytic                                   12 (24%)      4 (27%)      8 (16%)      5 (50%)     
   Nose                                               (49)         (11)         (48)         (15)         (47)         (10)         
      Inflammation, Suppurative                        2 (4%)       1 (9%)       1 (2%)                                             
      Lumen, Foreign Body                              1 (2%)                                                                       
      Lumen, Hemorrhage                                                                                    1 (2%)                   
      Mucosa, Inflammation, Suppurative                4 (8%)                    5 (10%)                   2 (4%)                   
      Nasolacrimal Duct, Inflammation, Suppurative                               1 (2%)                                             
      Respiratory Epithelium, Hyperplasia                                        3 (6%)                   14 (30%)      1 (10%)     
   Trachea                                            (49)         (11)         (50)         (15)         (48)         (10)         
      Inflammation, Suppurative                        3 (6%)                                              1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)                       (2)                       (2)                       
      Cataract                                         1 (33%)                   1 (50%)                   2 (100%)                 
      Inflammation, Chronic                                                                                1 (50%)                  
      Cornea, Inflammation, Necrotizing                                                                    1 (50%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05079-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:44  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Cornea, Necrosis                                 1 (33%)                                                                      
      Lens, Cataract                                   1 (33%)                                                                      
      Retina, Degeneration                             2 (67%)                   1 (50%)                   1 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (11)         (49)         (15)         (48)         (10)         
      Calculus Micro Observation Only                                                                      1 (2%)                   
      Cyst                                             3 (6%)                                              1 (2%)                   
      Hydronephrosis                                                             1 (2%)                    1 (2%)                   
      Inflammation, Chronic                                         1 (9%)                                                          
      Nephropathy                                     45 (92%)      4 (36%)     47 (96%)      9 (60%)     43 (90%)      3 (30%)     
      Medulla, Inflammation                                                      1 (2%)                    1 (2%)                   
      Renal Tubule, Necrosis                                                     1 (2%)                                             
   Ureter                                                                                                 (1)                       
      Calculus Micro Observation Only                                                                      1 (100%)                 
   Urethra                                                                                                (1)                       
      Fibrosis                                                                                             1 (100%)                 
   Urinary Bladder                                    (49)         (11)         (48)         (15)         (47)         (9)          
      Calculus Gross Observation                                                                           1 (2%)                   
      Calculus Gross Observation, Single                            1 (9%)                                                          
      Calculus Micro Observation Only                                                         1 (7%)                                
      Inflammation                                     1 (2%)                                                                       
      Mucosa, Hyperplasia                                                                                  1 (2%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------