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TDMS Study 05079-01 Pathology Tables

NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  14807966

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 8| 7| 5| 6| 7| 8| 7| 7| 7| 8| 8| 7| 8| 3| 8| 5| 7| 8| 8| 8| 5| 6| 6|             
                             DAY ON TEST   | 0| 4| 6| 1| 5| 8| 8| 6| 6| 1| 6| 6| 6| 7| 6| 7| 0| 6| 6| 2| 0| 4| 8| 2| 9|             
                                           | 8| 7| 2| 9| 8| 8| 9| 2| 8| 6| 7| 2| 2| 2| 2| 0| 5| 8| 6| 7| 0| 1| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 5| 6| 8| 1| 2| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 5| 6| 7| 8| 9|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                      X     X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |          +        +                                                      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
      Pheochromocytoma Benign              | X                    X  X     X  X        X              X  X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                                        X        X  X  X     X  X     X   |             
      Pars Distalis, Carcinoma             |       X                                                  X              X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Carcinoma         |                                                                          |             
      C-Cell, Adenoma                      |       X                                         X              X         |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 8| 7| 5| 6| 7| 8| 7| 7| 7| 8| 8| 7| 8| 3| 8| 5| 7| 8| 8| 8| 5| 6| 6|             
                             DAY ON TEST   | 0| 4| 6| 1| 5| 8| 8| 6| 6| 1| 6| 6| 6| 7| 6| 7| 0| 6| 6| 2| 0| 4| 8| 2| 9|             
                                           | 8| 7| 2| 9| 8| 8| 9| 2| 8| 6| 7| 2| 2| 2| 2| 0| 5| 8| 6| 7| 0| 1| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 5| 6| 8| 1| 2| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 5| 6| 7| 8| 9|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |                               X                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        | X                 X  X                                      X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Leukemia Mononuclear         |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Adenocarcinoma, Metastatic, Thyroid  |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Thyroid  |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X                                      X     X     X         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                              X                           |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |                                                 X     X  X     X         |             
      Fibroma                              |                                                                         X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandible, Sarcoma                    |          X                                                               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 8| 7| 5| 6| 7| 8| 7| 7| 7| 8| 8| 7| 8| 3| 8| 5| 7| 8| 8| 8| 5| 6| 6|             
                             DAY ON TEST   | 0| 4| 6| 1| 5| 8| 8| 6| 6| 1| 6| 6| 6| 7| 6| 7| 0| 6| 6| 2| 0| 4| 8| 2| 9|             
                                           | 8| 7| 2| 9| 8| 8| 9| 2| 8| 6| 7| 2| 2| 2| 2| 0| 5| 8| 6| 7| 0| 1| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 5| 6| 8| 1| 2| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 5| 6| 7| 8| 9|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Benign                   |                                                       X                  |             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                          X              X|             
      Ependymoma Malignant                 |                                           X                              |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Thyroid  |                                                                          |             
          Gland                            |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Multiple, Metastatic,|                                                                          |             
           Mammary Gland                   |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                                 X                        |             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                    +                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X                                      X     X     X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5|            |
                             DAY ON TEST   | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8|            |
                                           | 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|     A      |
    CONTROL                                | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  M  +  M  +  +  M  +  +  +  +  +  M  M  +  +  +  M  +  +  +  A  A|  38        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X     X                       X        X     X  X     X           X   |         11 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                       +                  |   3        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X     X                       X                                       |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |    X                                                                     |          2 |
      Pheochromocytoma Benign              |                                  X  X     X  X              X            |         13 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  +  M  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M  +|  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X                                                               |          1 |
      Pars Distalis, Adenoma               |    X                 X     X  X  X        X     X     X  X     X  X     X|         19 |
      Pars Distalis, Carcinoma             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   5                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5|            |
                             DAY ON TEST   | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8|            |
                                           | 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|     A      |
    CONTROL                                | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, C-Cell, Carcinoma         |       X                                                                  |          1 |
      C-Cell, Adenoma                      |                                              X     X                     |          5 |
      C-Cell, Carcinoma                    |                                                       X  X               |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Carcinoma                            |                                  X           X                           |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granulosa Cell Tumor Malignant       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Polyp Stromal                        |          X                                                               |          5 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumbar, Leukemia Mononuclear         |          X                                                               |          1 |
      Pancreatic, Leukemia Mononuclear     |          X                                                               |          1 |
      Renal, Leukemia Mononuclear          |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Adenocarcinoma, Metastatic, Thyroid  |                                                                          |            |
          Gland                            |       X                                                                  |          1 |
      Leukemia Mononuclear                 |          X                       X                                       |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                                  X                                       |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Adenocarcinoma, Metastatic, Thyroid  |                                                                          |            |
          Gland                            |       X                                                                  |          1 |
      Leukemia Mononuclear                 |          X                       X                                       |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |    X                             X        X                              |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X     X                       X        X     X  X     X           X   |         13 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Thymoma Benign                       |                                                                X         |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5|            |
                             DAY ON TEST   | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8|            |
                                           | 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|     A      |
    CONTROL                                | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |                                                                         X|          2 |
      Adenoma                              |             X                                                            |          1 |
      Fibroadenoma                         | X  X           X        X           X                 X        X         |         11 |
      Fibroma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mandible, Sarcoma                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   1        |
      Leukemia Mononuclear                 |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Astrocytoma Benign                   |                                                                          |          1 |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          2 |
      Ependymoma Malignant                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma, Metastatic, Thyroid  |                                                                          |            |
          Gland                            |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma, Multiple, Metastatic,|                                                                          |            |
           Mammary Gland                   |                                                                         X|          1 |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                       X        X     X        X           X   |          7 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +                    +                       +      |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5|            |
                             DAY ON TEST   | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8|            |
                                           | 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|     A      |
    CONTROL                                | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X     X                       X        X     X  X     X           X   |         13 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 8| 8| 8| 7| 7| 8| 4| 7| 7| 5| 8| 6| 8| 5| 8| 7| 8| 8| 7| 5| 5| 7|             
                             DAY ON TEST   | 1| 6| 6| 6| 6| 6| 6| 9| 1| 8| 4| 2| 6| 4| 9| 6| 0| 6| 6| 4| 1| 6| 2| 6| 0|             
                                           | 2| 2| 6| 2| 2| 2| 2| 8| 5| 2| 7| 0| 6| 1| 0| 2| 8| 2| 8| 9| 8| 0| 6| 1| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 7|             
    6 MG/M3                                | 4| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 3| 4| 5| 7| 8| 2| 3| 4| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  A  +  +  A  A  +  +  +  +  A  +  A  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  A  +  +  A  A  +  +  +  +  A  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  M  +  +  +  M  +  M  M  +  A  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  A  +  +  +  +  A  +  +  A  A  +  +  +  +  A  +  +  +  +  A  A  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  A  +  +  A  A  +  +  +  +  A  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Leukemia Mononuclear                 |       X     X  X                          X  X                    X      |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                   +                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic,      |                                                                          |             
          Metastatic                       |                      X                                                   |             
      Sarcoma                              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
      Sarcoma, Metastatic                  |                                                                      X   |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Adamantinoma Benign                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                  +                                       |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                             X                       X      |             
      Pheochromocytoma Malignant           |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 8| 8| 8| 7| 7| 8| 4| 7| 7| 5| 8| 6| 8| 5| 8| 7| 8| 8| 7| 5| 5| 7|             
                             DAY ON TEST   | 1| 6| 6| 6| 6| 6| 6| 9| 1| 8| 4| 2| 6| 4| 9| 6| 0| 6| 6| 4| 1| 6| 2| 6| 0|             
                                           | 2| 2| 6| 2| 2| 2| 2| 8| 5| 2| 7| 0| 6| 1| 0| 2| 8| 2| 8| 9| 8| 0| 6| 1| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 7|             
    6 MG/M3                                | 4| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 3| 4| 5| 7| 8| 2| 3| 4| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign              | X  X              X           X              X           X              X|             
      Bilateral, Pheochromocytoma Benign   |                                                                X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  I  +  +  +|             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
      Pars Distalis, Adenoma               | X           X           X     X                       X  X              X|             
      Pars Distalis, Carcinoma             |          X                          X     X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Carcinoma                    |                                        X                    X            |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Granulosa-Theca Tumor Benign         |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic,      |                                                                          |             
          Metastatic                       |                      X                                                   |             
      Polyp Stromal                        |       X  X                       X           X                           |             
      Sarcoma Stromal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|             
      Leukemia Mononuclear                 |       X                                   X                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                   X                              |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant Mixed             |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 8| 8| 8| 7| 7| 8| 4| 7| 7| 5| 8| 6| 8| 5| 8| 7| 8| 8| 7| 5| 5| 7|             
                             DAY ON TEST   | 1| 6| 6| 6| 6| 6| 6| 9| 1| 8| 4| 2| 6| 4| 9| 6| 0| 6| 6| 4| 1| 6| 2| 6| 0|             
                                           | 2| 2| 6| 2| 2| 2| 2| 8| 5| 2| 7| 0| 6| 1| 0| 2| 8| 2| 8| 9| 8| 0| 6| 1| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 7|             
    6 MG/M3                                | 4| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 3| 4| 5| 7| 8| 2| 3| 4| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sarcoma, Metastatic                  |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  A  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                   X                              |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X  X                          X  X                 X  X      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Mixed Tumor Malignant                |                                                                          |             
      Myxoma                               |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |       X     X  X           X                             X     X     X   |             
      Fibroma                              |          X                                                               |             
      Lymphoma Malignant Lymphocytic,      |                                                                          |             
          Metastatic                       |                      X                                                   |             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Mandible, Sarcoma, Metastatic        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Liposarcoma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                     X                                    |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 8| 8| 8| 7| 7| 8| 4| 7| 7| 5| 8| 6| 8| 5| 8| 7| 8| 8| 7| 5| 5| 7|             
                             DAY ON TEST   | 1| 6| 6| 6| 6| 6| 6| 9| 1| 8| 4| 2| 6| 4| 9| 6| 0| 6| 6| 4| 1| 6| 2| 6| 0|             
                                           | 2| 2| 6| 2| 2| 2| 2| 8| 5| 2| 7| 0| 6| 1| 0| 2| 8| 2| 8| 9| 8| 0| 6| 1| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 7|             
    6 MG/M3                                | 4| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 3| 4| 5| 7| 8| 2| 3| 4| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |       X     X                             X                    X  X      |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +  +                                         +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Lipoma                               |                                                                          |             
      Lymphoma Malignant Lymphocytic,      |                                                                          |             
          Metastatic                       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X  X              X           X  X                 X  X      |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant Mixed             |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7|            |
                             DAY ON TEST   | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8|            |
                                           | 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4|     A      |
    6 MG/M3                                | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     +  +  A  +  A  +  A  +  A  +  A  +  +  +  +  +  A  +  +  A  A|  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +  +  M  +  M  +  A  +  +  +  A  +  M  +  +  +  +  +  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  A  +  A  +  +  +  A  M  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +  +  A  +  A  A  A  +  +  +  A  +  A  +  +  +  A  +  +  A  A|  32        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  A  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hepatocellular Carcinoma             |                                                                X         |          1 |
      Leukemia Mononuclear                 |             X     X  X           X        X        X  X        X     X   |         15 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Neoplastic Nodule                    |    X                       X                 X                           |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Leukemia Mononuclear                 |                                                       X        X         |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic,      |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
      Leukemia Mononuclear                 |                                                       X        X         |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                             +            |   2        |
      Sarcoma, Metastatic                  |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                 +                        |   1        |
      Adamantinoma Benign                  |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +  +                                                                  |   3        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                               X                       X        X         |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7|            |
                             DAY ON TEST   | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8|            |
                                           | 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4|     A      |
    6 MG/M3                                | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                   X                       X                              |          5 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |       X        X                             X                           |         10 |
      Bilateral, Pheochromocytoma Benign   |    X                                                           X        X|          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Adenoma                              |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +     +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  I  +  +  M  +|  42        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                                                                X         |          2 |
      Pars Distalis, Adenoma               |    X        X     X                 X  X     X     X  X     X        X  X|         18 |
      Pars Distalis, Carcinoma             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
      Follicular Cell, Adenoma             |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
      Granulosa Cell Tumor Benign          |                X                 X                                       |          2 |
      Granulosa-Theca Tumor Benign         |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic,      |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
      Polyp Stromal                        | X                                            X  X                        |          7 |
      Sarcoma Stromal                      |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  43        |
      Leukemia Mononuclear                 |                                                                X         |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pancreatic, Leukemia Mononuclear     |                                                                      X   |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7|            |
                             DAY ON TEST   | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8|            |
                                           | 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4|     A      |
    6 MG/M3                                | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                   X                                   X        X         |          5 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  46        |
      Leukemia Mononuclear                 |                   X                       X                    X     X   |          5 |
      Lymphoma Malignant Lymphocytic       |                            X                                             |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Sarcoma, Metastatic                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  44        |
      Leukemia Mononuclear                 |                   X                       X           X        X         |          6 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |             X     X                       X           X        X  X  X   |          8 |
      Lymphoma Malignant Lymphocytic       |                            X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |             X  X  X  X        X  X        X        X  X        X  X  X   |         19 |
      Lymphoma Malignant Lymphocytic       |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +     I  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Leukemia Mononuclear                 |                                                                X         |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Mixed Tumor Malignant                |                         X                                                |          1 |
      Myxoma                               |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                                                    X           X         |          2 |
      Fibroadenoma                         |                                     X                 X              X   |         10 |
      Fibroma                              |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic,      |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Keratoacanthoma                      |                                                    X                     |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7|            |
                             DAY ON TEST   | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8|            |
                                           | 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4|     A      |
    6 MG/M3                                | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mandible, Sarcoma, Metastatic        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                    +                     |   1        |
      Liposarcoma                          |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |             X        X                    X                    X         |          9 |
      Lymphoma Malignant Lymphocytic       |                            X                                             |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +  +  +  +  +  +  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                     +           +  +   |   7        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                                                                X         |          2 |
      Lipoma                               |                                                    X                     |          1 |
      Lymphoma Malignant Lymphocytic,      |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  M  +  +  +  +  +|  45        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |             X  X  X  X        X  X        X        X  X        X  X  X   |         20 |
      Lymphoma Malignant Lymphocytic       |                            X                                             |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|             
                             DAY ON TEST   | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|             
                                           | 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|             
    18 MG/M3                               | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  A  +  +  +  A  +  A  A  +  +  +  A  +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa-Theca Tumor Malignant,     |                                                                          |             
           Metastatic, Ovary               |                                                       X                  |             
      Leukemia Mononuclear                 |    X  X                 X  X                 X              X  X         |             
      Neoplastic Nodule                    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                   +      |             
      Squamous Cell Carcinoma              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                   X                                                      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                           +                              |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa-Theca Tumor Malignant,     |                                                                          |             
           Metastatic, Ovary               |                                                       X                  |             
      Leukemia Mononuclear                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Granulosa-Theca Tumor Malignant,     |                                                                          |             
           Metastatic, Ovary               |                                                       X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Granulosa-Theca Tumor Malignant,     |                                                                          |             
           Metastatic, Ovary               |                                                       X                  |             
      Leukemia Mononuclear                 |       X                          X                          X  X         |             
      Pheochromocytoma Malignant           |          X                                X  X                       X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|             
                             DAY ON TEST   | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|             
                                           | 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|             
    18 MG/M3                               | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign              | X        X                    X           X     X                    X   |             
      Bilateral, Pheochromocytoma Malignant|    X                                                                     |             
      Bilateral, Pheochromocytoma Benign   |       X        X     X                 X                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
      Pars Distalis, Adenoma               |          X  X  X  X        X              X  X     X                 X   |             
      Pars Distalis, Carcinoma             |                                                          X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      C-Cell, Adenoma                      | X                    X                                      X            |             
      C-Cell, Carcinoma                    |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                      X   |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Bilateral, Granulosa-Theca Tumor     |                                                                          |             
          Malignant                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |    X                             X                          X  X         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                             X            |             
      Inguinal, Leukemia Mononuclear       |                                                             X            |             
      Pancreatic, Leukemia Mononuclear     |       X                                                     X  X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                                      X              X            |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Lung                            |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                      X              X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|             
                             DAY ON TEST   | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|             
                                           | 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|             
    18 MG/M3                               | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Primary Site                     |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                                     X                                    |             
      Granulosa-Theca Tumor Malignant,     |                                                                          |             
           Metastatic, Ovary               |                                                       X                  |             
      Leukemia Mononuclear                 |    X  X                 X                    X              X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |    X  X                          X                          X  X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                 X  X     X           X              X  X        X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |       X                                      X              X            |             
      Schwannoma Benign                    |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |          X                                   X                           |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         | X                    X        X              X              X        X   |             
      Fibrosarcoma                         |                X                                                         |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                          X               |             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X              X     X                             X                 X   |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       | X                             X                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Granulosa-Theca Tumor Malignant,     |                                                                          |             
           Metastatic, Ovary               |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|             
                             DAY ON TEST   | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|             
                                           | 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|             
    18 MG/M3                               | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |    X  X                                      X              X           X|             
      Squamous Cell Carcinoma              |                                                       X                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                +     +     +         |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |    X                                                        X            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                        X            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                 X  X     X           X              X  X        X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6|            |
                             DAY ON TEST   | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7|            |
                                           | 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8|     A      |
    18 MG/M3                               | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  A  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  A  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|  38        |
      Leukemia Mononuclear                 |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granulosa-Theca Tumor Malignant,     |                                                                          |            |
           Metastatic, Ovary               |                                                                          |          1 |
      Leukemia Mononuclear                 |                   X        X                       X     X        X     X|         13 |
      Neoplastic Nodule                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma                         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granulosa-Theca Tumor Malignant,     |                                                                          |            |
           Metastatic, Ovary               |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                          X               |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Granulosa-Theca Tumor Malignant,     |                                                                          |            |
           Metastatic, Ovary               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6|            |
                             DAY ON TEST   | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7|            |
                                           | 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8|     A      |
    18 MG/M3                               | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Granulosa-Theca Tumor Malignant,     |                                                                          |            |
           Metastatic, Ovary               |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X                                               X|          6 |
      Pheochromocytoma Malignant           |                            X        X              X                     |          7 |
      Pheochromocytoma Benign              |          X                 X                    X  X              X      |         11 |
      Bilateral, Pheochromocytoma Malignant|    X  X                                                                  |          3 |
      Bilateral, Pheochromocytoma Benign   |                X                       X  X                              |          7 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                            X                                      X      |          3 |
      Pars Distalis, Adenoma               |    X     X     X     X     X  X        X        X        X     X  X     X|         21 |
      Pars Distalis, Carcinoma             |                                  X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Adenoma                      |                               X           X        X                     |          6 |
      C-Cell, Carcinoma                    |                                                                         X|          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                            X                                             |          2 |
      Bilateral, Granulosa-Theca Tumor     |                                                                          |            |
          Malignant                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                          X               |          2 |
      Polyp Stromal                        |                               X  X  X                             X      |          4 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6|            |
                             DAY ON TEST   | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7|            |
                                           | 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8|     A      |
    18 MG/M3                               | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                    X                    X|          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                            X                       X                     |          6 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Lung                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                            X                                   X  X     X|          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  47        |
      Carcinoma, Metastatic, Uncertain     |                                                                          |            |
          Primary Site                     |                         X                                                |          1 |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Granulosa-Theca Tumor Malignant,     |                                                                          |            |
           Metastatic, Ovary               |                                                                          |          1 |
      Leukemia Mononuclear                 |                            X                       X                     |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                            X                       X           X        X|          9 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X     X  X                       X     X     X  X  X  X|         18 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                   X        X                       X                     |          6 |
      Schwannoma Benign                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |                                                                          |          2 |
      Adenoma                              |                                        X           X                     |          2 |
      Fibroadenoma                         |    X  X           X        X  X  X           X                           |         13 |
      Fibrosarcoma                         |                                                                          |          1 |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Keratoacanthoma                      |                                                       X                  |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6|            |
                             DAY ON TEST   | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7|            |
                                           | 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8|     A      |
    18 MG/M3                               | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  I  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                              X              X        X   |          8 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                    X                     |          1 |
      Alveolar/Bronchiolar Carcinoma       |       X                                X                                 |          4 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                           X                              |          1 |
      Granulosa-Theca Tumor Malignant,     |                                                                          |            |
           Metastatic, Ovary               |                                                                          |          1 |
      Leukemia Mononuclear                 |                   X        X                             X     X  X      |         10 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +        +  +     +  +  +  +     +  +                 +     +|  15        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                        +                                 |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                            X                                             |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X     X  X                       X     X     X  X  X  X|         18 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 7| 3| 7| 1| 7| 5| 4| 7| 5| 3| 1| 3| 7| 6| 5| 6| 7| 7| 7| 1| 1|        |            |
                             DAY ON TEST   | 6| 3| 3| 3| 9| 3| 5| 5| 3| 5| 3| 9| 3| 2| 7| 5| 2| 1| 1| 3| 8| 9|        |            |
                                           | 2| 9| 3| 9| 2| 9| 6| 0| 9| 6| 3| 3| 3| 8| 3| 6| 2| 6| 8| 9| 0| 4|        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |     O      |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|        |     T      |
                               ANIMAL ID   | 0| 0| 0| 1| 2| 3| 3| 4| 5| 5| 6| 7| 7| 7| 9| 0| 0| 0| 2| 2| 2| 3|        |     A      |
    CONTROL                                | 4| 7| 9| 0| 5| 3| 4| 9| 3| 4| 0| 5| 8| 9| 8| 1| 4| 5| 1| 3| 6| 1|        |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  M  +  +  +     +  +  M  +  +        +           +     +         |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +     +  +  +  +  +        +           +     +         |  14        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M     +  +  +  +  +        +           +     +         |  14        |
      Bilateral, Pheochromocytoma Benign   | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +     M  +  +  +  +        +           +     +         |  14        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +     +  +  M  +  M        +           +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Pars Distalis, Adenoma               |                X        X                    X           X               |          4 |
      Pars Distalis, Carcinoma             | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  M  +  +  +  +  +     +  +  +  +  M        +           +     +         |  13        |
      C-Cell, Adenoma                      |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 7| 3| 7| 1| 7| 5| 4| 7| 5| 3| 1| 3| 7| 6| 5| 6| 7| 7| 7| 1| 1|        |            |
                             DAY ON TEST   | 6| 3| 3| 3| 9| 3| 5| 5| 3| 5| 3| 9| 3| 2| 7| 5| 2| 1| 1| 3| 8| 9|        |            |
                                           | 2| 9| 3| 9| 2| 9| 6| 0| 9| 6| 3| 3| 3| 8| 3| 6| 2| 6| 8| 9| 0| 4|        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |     O      |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|        |     T      |
                               ANIMAL ID   | 0| 0| 0| 1| 2| 3| 3| 4| 5| 5| 6| 7| 7| 7| 9| 0| 0| 0| 2| 2| 2| 3|        |     A      |
    CONTROL                                | 4| 7| 9| 0| 5| 3| 4| 9| 3| 4| 0| 5| 8| 9| 8| 1| 4| 5| 1| 3| 6| 1|        |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Polyp                                |    X                                                                     |          1 |
      Polyp Stromal                        |    X                                                                     |          1 |
      Sarcoma Stromal                      | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  M  +  +  M     M  +  +  +  +        +           M     +         |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  M  +  +        M     +  +  +        +           M     +         |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +     M  M  +  M  +        +           M     +         |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +     +  +  +  +  +        +                 +         |  14        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +     M  +  +  +  +        +           +     +         |  14        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Adenoma                              |    X                    X                                                |          2 |
      Fibroadenoma                         |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 7| 3| 7| 1| 7| 5| 4| 7| 5| 3| 1| 3| 7| 6| 5| 6| 7| 7| 7| 1| 1|        |            |
                             DAY ON TEST   | 6| 3| 3| 3| 9| 3| 5| 5| 3| 5| 3| 9| 3| 2| 7| 5| 2| 1| 1| 3| 8| 9|        |            |
                                           | 2| 9| 3| 9| 2| 9| 6| 0| 9| 6| 3| 3| 3| 8| 3| 6| 2| 6| 8| 9| 0| 4|        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |     O      |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|        |     T      |
                               ANIMAL ID   | 0| 0| 0| 1| 2| 3| 3| 4| 5| 5| 6| 7| 7| 7| 9| 0| 0| 0| 2| 2| 2| 3|        |     A      |
    CONTROL                                | 4| 7| 9| 0| 5| 3| 4| 9| 3| 4| 0| 5| 8| 9| 8| 1| 4| 5| 1| 3| 6| 1|        |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 3| 1| 3| 7| 7| 7| 3| 5| 7| 1| 5| 7| 7| 7| 5| 5| 7| 1| 7|        |            |
                             DAY ON TEST   | 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 5| 5| 3| 9| 3|        |            |
                                           | 5| 9| 9| 3| 2| 3| 9| 9| 9| 3| 0| 4| 3| 6| 6| 9| 9| 6| 6| 9| 4| 9|        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|        |     T      |
                               ANIMAL ID   | 1| 1| 1| 2| 4| 4| 4| 6| 6| 7| 8| 9| 9| 9| 1| 1| 1| 2| 3| 3| 3| 4|        |     A      |
    6 MG/M3                                | 3| 5| 9| 2| 1| 2| 6| 1| 5| 2| 7| 0| 3| 4| 3| 4| 9| 0| 4| 5| 9| 2|        |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +  +  +  +  +  +        +  M     +  +  +  +  +  +  +         |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +            |  17        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +            |  17        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +     +  +        +  +        +  +  +  +  +  +         |  16        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Pheochromocytoma Benign              |                      X  X                    X  X                        |          4 |
      Bilateral, Pheochromocytoma Benign   |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  I         |  17        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +  M        +  +     M  +  +  +  +  M  +         |  15        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Pars Distalis, Adenoma               |    X              X  X  X                    X  X        X               |          7 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  M  I         |  16        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 3| 1| 3| 7| 7| 7| 3| 5| 7| 1| 5| 7| 7| 7| 5| 5| 7| 1| 7|        |            |
                             DAY ON TEST   | 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 5| 5| 3| 9| 3|        |            |
                                           | 5| 9| 9| 3| 2| 3| 9| 9| 9| 3| 0| 4| 3| 6| 6| 9| 9| 6| 6| 9| 4| 9|        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|        |     T      |
                               ANIMAL ID   | 1| 1| 1| 2| 4| 4| 4| 6| 6| 7| 8| 9| 9| 9| 1| 1| 1| 2| 3| 3| 3| 4|        |     A      |
    6 MG/M3                                | 3| 5| 9| 2| 1| 2| 6| 1| 5| 2| 7| 0| 3| 4| 3| 4| 9| 0| 4| 5| 9| 2|        |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Granulosa-Theca Tumor Malignant      |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Polyp Stromal                        |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +  +  M  +  +  +  +        M  +     M  +  +  +  M  +  +         |  14        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +  +  +  +  +  +  +  +  +        M  +     +  +  +  +  +  +  +         |  17        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    M  +  +  +  +  +  +  +  +        +  M     +  +  +  +  M  +  +         |  15        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Fibroadenoma                         |    X                    X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Alveolar/Bronchiolar Adenoma         |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 3| 1| 3| 7| 7| 7| 3| 5| 7| 1| 5| 7| 7| 7| 5| 5| 7| 1| 7|        |            |
                             DAY ON TEST   | 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 5| 5| 3| 9| 3|        |            |
                                           | 5| 9| 9| 3| 2| 3| 9| 9| 9| 3| 0| 4| 3| 6| 6| 9| 9| 6| 6| 9| 4| 9|        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|        |     T      |
                               ANIMAL ID   | 1| 1| 1| 2| 4| 4| 4| 6| 6| 7| 8| 9| 9| 9| 1| 1| 1| 2| 3| 3| 3| 4|        |     A      |
    6 MG/M3                                | 3| 5| 9| 2| 1| 2| 6| 1| 5| 2| 7| 0| 3| 4| 3| 4| 9| 0| 4| 5| 9| 2|        |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 6| 5| 6| 5| 5| 3| 1| 6| 7| 7| 5| 3| 7| 3| 6| 6| 3| 6| 7| 5| 1|        |            |
                             DAY ON TEST   | 9| 5| 5| 9| 9| 5| 3| 9| 2| 3| 2| 5| 3| 3| 7| 7| 4| 3| 2| 3| 5| 9|        |            |
                                           | 2| 0| 6| 8| 4| 6| 3| 3| 1| 9| 6| 6| 3| 9| 6| 7| 8| 3| 1| 9| 8| 4|        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|        |     T      |
                               ANIMAL ID   | 5| 6| 6| 8| 8| 8| 8| 1| 1| 1| 1| 2| 3| 3| 3| 6| 6| 6| 7| 7| 8| 8|        |     A      |
    18 MG/M3                               | 9| 1| 8| 4| 5| 7| 8| 0| 1| 3| 4| 9| 4| 5| 7| 0| 1| 2| 8| 9| 3| 4|        |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     M        M  +  +     +     M  +  +           +     M     +         |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +        +  M  +     +     +  +  +           +     +     +         |  11        |
      Bilateral, Pheochromocytoma Benign   |                            X           X                 X               |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +        +  +  M     +     M  M  +           +     +     M         |   8        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
      Pars Distalis, Adenoma               |       X        X           X        X  X                                 |          5 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +        +  +  +     +     I  +  +           +     +     +         |  11        |
      C-Cell, Carcinoma                    |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 6| 5| 6| 5| 5| 3| 1| 6| 7| 7| 5| 3| 7| 3| 6| 6| 3| 6| 7| 5| 1|        |            |
                             DAY ON TEST   | 9| 5| 5| 9| 9| 5| 3| 9| 2| 3| 2| 5| 3| 3| 7| 7| 4| 3| 2| 3| 5| 9|        |            |
                                           | 2| 0| 6| 8| 4| 6| 3| 3| 1| 9| 6| 6| 3| 9| 6| 7| 8| 3| 1| 9| 8| 4|        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|        |     T      |
                               ANIMAL ID   | 5| 6| 6| 8| 8| 8| 8| 1| 1| 1| 1| 2| 3| 3| 3| 6| 6| 6| 7| 7| 8| 8|        |     A      |
    18 MG/M3                               | 9| 1| 8| 4| 5| 7| 8| 0| 1| 3| 4| 9| 4| 5| 7| 0| 1| 2| 8| 9| 3| 4|        |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Polyp Stromal                        |                X           X                                             |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |            |
           Thyroid Gland                   |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |       +        +  +        +     +  +  M           +     +     +         |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +        +  +  +     +     +  M  +           +     +     +         |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
      Adenoma                              |                                  X                                       |          1 |
      Fibroadenoma                         |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
      Carcinoma, Metastatic, Thyroid Gland |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 6| 5| 6| 5| 5| 3| 1| 6| 7| 7| 5| 3| 7| 3| 6| 6| 3| 6| 7| 5| 1|        |            |
                             DAY ON TEST   | 9| 5| 5| 9| 9| 5| 3| 9| 2| 3| 2| 5| 3| 3| 7| 7| 4| 3| 2| 3| 5| 9|        |            |
                                           | 2| 0| 6| 8| 4| 6| 3| 3| 1| 9| 6| 6| 3| 9| 6| 7| 8| 3| 1| 9| 8| 4|        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|        |     T      |
                               ANIMAL ID   | 5| 6| 6| 8| 8| 8| 8| 1| 1| 1| 1| 2| 3| 3| 3| 6| 6| 6| 7| 7| 8| 8|        |     A      |
    18 MG/M3                               | 9| 1| 8| 4| 5| 7| 8| 0| 1| 3| 4| 9| 4| 5| 7| 0| 1| 2| 8| 9| 3| 4|        |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
   Urinary Bladder                         | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|             
                             DAY ON TEST   | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|             
                                           | 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X           X     X  X  X     X  X        X     X  X         |             
      Neoplastic Nodule, Multiple          |                               X        X                                 |             
      Osteosarcoma, Multiple, Metastatic,  |                                                                          |             
           Bone                            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                                        |             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                             X                       X                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                          +           +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X     X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X           X              X            |             
      Pheochromocytoma Malignant           |                   X                                                  X   |             
      Pheochromocytoma Benign              |                   X        X  X        X     X                 X  X  X  X|             
      Bilateral, Pheochromocytoma Malignant|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|             
                             DAY ON TEST   | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|             
                                           | 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Bilateral, Pheochromocytoma Benign   | X              X                    X     X        X                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
      Pars Distalis, Adenoma               |                X                                            X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |       X                                                                  |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                X                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                         X                              |             
      Mesothelioma Benign                  |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|    X        X  X  X                          X  X  X           X        X|             
      Interstitial Cell, Adenoma           |                         X  X  X     X  X  X              X        X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                    X                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Leukemia Mononuclear          |                                           X                              |             
      Lumbar, Leukemia Mononuclear         | X                                                                        |             
      Pancreatic, Leukemia Mononuclear     | X                       X     X  X                    X     X            |             
      Renal, Leukemia Mononuclear          |                         X                                                |             
      Thoracic, Leukemia Mononuclear       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 | X                             X  X        X  X        X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|             
                             DAY ON TEST   | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|             
                                           | 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                               X  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                             X  X           X        X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                       X     X  X                    X  X     X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                                                          |             
      Leukemia Mononuclear                 | X  X        X           X  X  X  X  X     X  X        X  X  X  X         |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                             X  X           X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Thymoma Malignant                    |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Scapula, Osteosarcoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hindlimb, Leukemia Mononuclear       |                                                                          |             
      Sternal, Leukemia Mononuclear        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Leukemia Mononuclear                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X           X     X  X  X     X  X        X     X  X         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Osteosarcoma, Multiple, Metastatic,  |                                                                          |             
           Bone                            |                                                                          |             
      Schwannoma Malignant, Metastatic     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Chondroma                            |                                                                          |             
      Mucosa, Leukemia Mononuclear         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|             
                             DAY ON TEST   | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|             
                                           | 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X        X           X                  |             
      Renal Tubule, Carcinoma              |                                              X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                         X                              |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Papilloma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X        X           X  X  X  X  X     X  X        X  X  X  X         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Mesothelioma Benign                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6|            |
                             DAY ON TEST   | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2|            |
                                           | 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|     T      |
                               ANIMAL ID   | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2|     A      |
    CONTROL                                | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  A  A  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  A  +  +  A  +  A  +  M  +  +  +  A  A  +  +|  42        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  A  A  +  +|  43        |
      Leukemia Mononuclear                 |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +     M  +  +  +  +  +  +  M  A  +  A  +  +  +  +  +  A  A  +  M|  38        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  A  +  +     +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  A  A  +  +|  39        |
      Leukemia Mononuclear                 |                X                                                         |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  A  +  +     +  +  +  +  +  A  +  +  A  +  A  +  +  +  +  A  A  A  +  +|  40        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |    X  X  X     X                 X              X           X            |         18 |
      Neoplastic Nodule, Multiple          |                                                                          |          2 |
      Osteosarcoma, Multiple, Metastatic,  |                                                                          |            |
           Bone                            |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   2        |
      Leukemia Mononuclear                 |    X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Leukemia Mononuclear                 |    X     X     X                                                         |          6 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                               +              +                           |   4        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |          X     X                 X                          X            |          6 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6|            |
                             DAY ON TEST   | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2|            |
                                           | 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|     T      |
                               ANIMAL ID   | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2|     A      |
    CONTROL                                | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                  X        X                              |          5 |
      Pheochromocytoma Malignant           |                                                                          |          2 |
      Pheochromocytoma Benign              |                   X     X                          X                 X   |         13 |
      Bilateral, Pheochromocytoma Malignant|                               X                                          |          1 |
      Bilateral, Pheochromocytoma Benign   |          X           X                 X  X  X  X     X                  |         12 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
      Adenoma                              |                         X                                                |          1 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|  47        |
      Leukemia Mononuclear                 |          X                       X                          X            |          4 |
      Pars Distalis, Adenoma               |                X     X     X     X  X     X              X     X     X  X|         12 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +|  45        |
      C-Cell, Adenoma                      | X                    X                                                   |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                   X                                                      |          1 |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                             X            |          3 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                             X            |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                  X                                       |          3 |
      Mesothelioma Benign                  |                                                          X               |          1 |
      Bilateral, Interstitial Cell, Adenoma|       X  X              X              X     X     X  X     X        X   |         18 |
      Interstitial Cell, Adenoma           |                      X        X  X              X              X         |         13 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6|            |
                             DAY ON TEST   | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2|            |
                                           | 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|     T      |
                               ANIMAL ID   | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2|     A      |
    CONTROL                                | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |    X  X        X                                                         |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Lumbar, Leukemia Mononuclear         |                X                                                         |          2 |
      Pancreatic, Leukemia Mononuclear     |    X     X     X                                            X            |         10 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
      Thoracic, Leukemia Mononuclear       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +     +  +  +  M  +  +  +  I  M  +  +  M  +  +  M  +  +  +  M  +|  41        |
      Leukemia Mononuclear                 |    X  X  X     X                                            X            |         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +|  46        |
      Leukemia Mononuclear                 |    X     X     X                 X                          X            |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |    X  X  X     X                          X                 X            |         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |    X     X     X                 X                          X            |         12 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosarcoma                         |                                                                   X      |          1 |
      Leukemia Mononuclear                 |    X  X  X     X        X        X        X     X  X        X            |         24 |
      Osteosarcoma, Metastatic, Bone       |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |    X     X     X                          X                 X            |          9 |
      Lymphoma Malignant Lymphocytic       |                                                                      X   |          1 |
      Thymoma Malignant                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  45        |
      Adenocarcinoma                       |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Scapula, Osteosarcoma                |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |    +                                                                     |   1        |
      Hindlimb, Leukemia Mononuclear       |    X                                                                     |          1 |
      Sternal, Leukemia Mononuclear        |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6|            |
                             DAY ON TEST   | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2|            |
                                           | 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|     T      |
                               ANIMAL ID   | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2|     A      |
    CONTROL                                | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Astrocytoma Malignant                |                                                 X                        |          1 |
      Leukemia Mononuclear                 |    X  X                          X                          X            |          5 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |          X     X                 X        X        X        X            |         16 |
      Lymphoma Malignant Lymphocytic       |                                                                      X   |          1 |
      Osteosarcoma, Multiple, Metastatic,  |                                                                          |            |
           Bone                            |                                                                         X|          1 |
      Schwannoma Malignant, Metastatic     |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Chondroma                            | X                                                                        |          1 |
      Mucosa, Leukemia Mononuclear         |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                        +                          +      |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |    X           X                 X                          X            |          7 |
      Renal Tubule, Carcinoma              |                                                 X                        |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |          X                                                               |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                      X   |          1 |
      Papilloma                            |                                                    X                     |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |    X  X  X     X        X        X        X     X  X        X            |         24 |
      Lymphoma Malignant Lymphocytic       |                                                                      X   |          1 |
      Mesothelioma Benign                  |                                                          X               |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 1| 8| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 9| 7| 7| 8| 8| 0| 1| 2| 4| 8| 2| 9| 5| 5| 9| 9| 9| 9| 8| 8| 9| 9| 4| 6| 4|             
                                           | 9| 7| 3| 7| 6| 0| 1| 2| 6| 3| 7| 9| 7| 9| 1| 9| 9| 3| 1| 0| 9| 0| 0| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5|             
    6 MG/M3                                | 1| 3| 4| 5| 6| 8| 1| 2| 6| 8| 9| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 6| 7| 9|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  A  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  A  +  A  +  +  +  A  A  +  +  +  +  +  +  +  A  A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  A  +  A  +  +  +  A  A  +  +  +  +  +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                 X                          X     X     X        X|             
      Neoplastic Nodule, Multiple          | X                                                                        |             
      Hepatocyte, Adenoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                            X                                             |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                            +                          +                  |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                          X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |                                  X        X                             X|             
      Pheochromocytoma Complex             |                                                                          |             
      Pheochromocytoma Benign              |    X                                      X                              |             
      Bilateral, Pheochromocytoma Benign   |          X           X  X  X           X     X  X  X  X  X  X     X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                  X           X        X                  |             
      Pars Distalis, Carcinoma             |                                                          X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A|             
      C-Cell, Adenoma                      | X              X                             X                           |             
      C-Cell, Carcinoma                    |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 1| 8| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 9| 7| 7| 8| 8| 0| 1| 2| 4| 8| 2| 9| 5| 5| 9| 9| 9| 9| 8| 8| 9| 9| 4| 6| 4|             
                                           | 9| 7| 3| 7| 6| 0| 1| 2| 6| 3| 7| 9| 7| 9| 1| 9| 9| 3| 1| 0| 9| 0| 0| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5|             
    6 MG/M3                                | 1| 3| 4| 5| 6| 8| 1| 2| 6| 8| 9| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 6| 7| 9|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |          X                    X                                   X      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X     X           X  X  X                    X           X            |             
      Interstitial Cell, Adenoma           |       X        X  X              X     X  X  X        X  X     X     X  X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                 X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                    X                     |             
      Pancreatic, Leukemia Mononuclear     |    X                                               X                     |             
      Renal, Leukemia Mononuclear          |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                 X                          X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                          X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                          X           X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                    X                          X     X     X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 | X                                                                        |             
      Leukemia Mononuclear                 |    X  X                 X  X           X        X  X     X     X        X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M  +  +  +  +  +  +  +  +  +  +  I  +  M  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                         X                          X     X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 1| 8| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 9| 7| 7| 8| 8| 0| 1| 2| 4| 8| 2| 9| 5| 5| 9| 9| 9| 9| 8| 8| 9| 9| 4| 6| 4|             
                                           | 9| 7| 3| 7| 6| 0| 1| 2| 6| 3| 7| 9| 7| 9| 1| 9| 9| 3| 1| 0| 9| 0| 0| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5|             
    6 MG/M3                                | 1| 3| 4| 5| 6| 8| 1| 2| 6| 8| 9| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 6| 7| 9|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Keratoacanthoma                      |                                                                      X   |             
      Neurofibroma                         |                                                          X               |             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pelvis, Osteosarcoma                 |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                       X                  |             
      Leukemia Mononuclear                 |    X  X                    X                       X                     |             
      Osteosarcoma, Metastatic             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |    X                    X                          X                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                 X  X           X        X  X     X     X        X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7|            |
                             DAY ON TEST   | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4|            |
                                           | 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|     A      |
    6 MG/M3                                | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  A  +  +  +  A  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  A  +  +  +  A  +  +  A  +  A  +  +  +  A  +  +  A  +  +  A|  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X           X                 X        X     X     X  X  X      |         15 |
      Neoplastic Nodule, Multiple          |                                                                          |          1 |
      Hepatocyte, Adenoma                  |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibroma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +                    +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                 X     X                  |          2 |
      Pheochromocytoma Malignant           |                                                                          |          3 |
      Pheochromocytoma Complex             |                                              X           X               |          2 |
      Pheochromocytoma Benign              |       X           X              X           X     X     X     X         |          9 |
      Bilateral, Pheochromocytoma Benign   |    X     X  X           X  X  X           X                       X  X   |         21 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  M  +  A  +  M  +  M  +  M  +  +  M  +  +  +  +  +  +  A  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  45        |
      Adenoma                              |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7|            |
                             DAY ON TEST   | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4|            |
                                           | 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|     A      |
    6 MG/M3                                | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma               |             X     X  X     X     X        X  X                          X|         11 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
      C-Cell, Adenoma                      |                               X                                          |          4 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                   +                                                      |   1        |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Gland        |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                          X               |          1 |
      Carcinoma                            |             X        X                       X                           |          6 |
                                            __________________________________________________________________________|____________|
   Prostate                                | M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  45        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X        X     X  X     X              X  X  X     X  X  X  X|         24 |
      Interstitial Cell, Adenoma           |                         X                 X                 X            |         15 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                 X                        |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Leukemia Mononuclear       |                                                 X                        |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     | X                                               X                        |          4 |
      Renal, Leukemia Mononuclear          |                                                 X                        |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                 X           X  X         |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|  48        |
      Leukemia Mononuclear                 | X              X                                X           X            |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                 X           X  X         |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  A  +  +  +|  48        |
      Leukemia Mononuclear                 | X        X     X                                X           X            |         10 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7|            |
                             DAY ON TEST   | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4|            |
                                           | 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|     A      |
    6 MG/M3                                | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Leukemia Mononuclear                 | X        X  X  X     X                 X        X     X     X  X  X      |         21 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +  M|  40        |
      Leukemia Mononuclear                 | X              X                                                         |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibroma                              |                                                          X               |          2 |
      Keratoacanthoma                      |                               X                                          |          2 |
      Neurofibroma                         |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                         X|          1 |
      Subcutaneous Tissue, Fibroma         |          X                                                               |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pelvis, Osteosarcoma                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear                 | X                                               X     X     X  X         |          9 |
      Osteosarcoma, Metastatic             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  47                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7|            |
                             DAY ON TEST   | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4|            |
                                           | 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|     A      |
    6 MG/M3                                | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X        X  X  X     X                 X        X     X     X  X  X      |         21 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  48                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|             
                                           | 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
    18 MG/M3                               | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  A  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  M  M  M  +  +  +  +  +  +  M  A  +  +  +  +  M  +  +  +  A  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  A  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A|             
      Leukemia Mononuclear                 |       X                                         X                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 | X     X  X  X     X     X     X  X              X                    X   |             
      Neoplastic Nodule                    |             X                                                            |             
      Neoplastic Nodule, Multiple          |          X                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 |       X     X                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
      Fibrosarcoma                         |                                                                         X|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
      Fibrosarcoma                         |                                                                         X|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                        +                       +         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X                                                     X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 |                   X                             X                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 |          X        X              X              X                        |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
      Pheochromocytoma Malignant           |                                                          X               |             
      Pheochromocytoma Complex             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|             
                                           | 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
    18 MG/M3                               | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign              |                   X     X           X           X     X  X           X   |             
      Bilateral, Pheochromocytoma Malignant|                                                                          |             
      Bilateral, Pheochromocytoma Benign   |    X     X  X        X     X     X        X  X     X        X  X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  M  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  I  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  I  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                X  X                 X              X        X  X         |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      C-Cell, Adenoma                      |                   X              X                                       |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                         +                       +                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                              X                           |             
      Carcinoma                            |                                                       X                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X                                                      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|    X        X           X  X                 X  X  X  X        X  X      |             
      Interstitial Cell, Adenoma           |          X           X        X  X        X              X           X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +|             
      Leukemia Mononuclear                 |             X                    X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                  X                                       |             
      Inguinal, Leukemia Mononuclear       |                                                                   X      |             
      Pancreatic, Leukemia Mononuclear     |       X     X                    X              X                    X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X     X           X     X  X              X                 X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  I  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X  X     X        X              X                 X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|             
                                           | 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
    18 MG/M3                               | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |       X     X     X     X     X  X              X                 X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 | X     X  X  X     X     X     X  X              X                    X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 | X     X  X  X  X  X     X     X  X        X     X  X                 X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X     X     X        X              X                 X  X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Malignant         |                                                                      X   |             
      Fibrous Histiocytoma                 |                                              X                           |             
      Keratoacanthoma                      |                                        X           X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vertebra, Osteosarcoma               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X                    X  X              X                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                           X                              |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                           X                              |             
      Leukemia Mononuclear                 | X     X     X  X  X     X        X              X                 X      |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 |             X     X                                                      |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|             
                                           | 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
    18 MG/M3                               | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X  X  X  X     X     X  X        X     X  X              X  X   |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8|            |
                             DAY ON TEST   | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0|            |
                                           | 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7|     A      |
    18 MG/M3                               | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  A  +  +  +  +  +  A  A  +  +  A  +  +  +  +  +  A  +  A  +|  37        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  +  M  +  +  M  M  +  +  +  +  M  A  +  +  +  +  +  +  M  +  +|  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  M  +  A  M  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  A  A|  35        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A|  40        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |             X                 X  X                 X  X     X            |         16 |
      Neoplastic Nodule                    |                                                                          |          1 |
      Neoplastic Nodule, Multiple          |             X                                                        X   |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                                  X                                       |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Fibrosarcoma                         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Fibrosarcoma                         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                     +                                    |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                +           +                 +                           |   5        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8|            |
                             DAY ON TEST   | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0|            |
                                           | 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7|     A      |
    18 MG/M3                               | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                 X                        |          1 |
      Pheochromocytoma Malignant           |                         X  X  X     X        X                           |          6 |
      Pheochromocytoma Complex             |          X                                                               |          1 |
      Pheochromocytoma Benign              | X        X  X           X  X  X     X  X  X  X     X     X  X            |         20 |
      Bilateral, Pheochromocytoma Malignant|                                                                   X      |          1 |
      Bilateral, Pheochromocytoma Benign   |       X        X                                               X     X  X|         16 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Adenoma                              |                                                    X                 X   |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
      Pars Distalis, Adenoma               |       X                                   X     X              X         |         10 |
      Pars Intermedia, Adenoma             | X                                                  X                     |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      C-Cell, Adenoma                      |                         X                                                |          3 |
      Follicular Cell, Adenoma             |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                               +                                          |   3        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma Malignant               |                                                                   X      |          1 |
      Bilateral, Interstitial Cell, Adenoma|       X  X     X     X  X              X  X     X     X  X  X     X  X  X|         24 |
      Interstitial Cell, Adenoma           | X                 X           X     X              X                     |         12 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  54                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8|            |
                             DAY ON TEST   | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0|            |
                                           | 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7|     A      |
    18 MG/M3                               | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                             X            |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                  X                 X                     |         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                                                             X            |         10 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  I  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                                  X                    X     X            |         12 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                                                       X                  |         11 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |          X  X        X        X  X                 X  X     X        X   |         22 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  I  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  M|  43        |
      Leukemia Mononuclear                 |                                                                          |          8 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basosquamous Tumor Malignant         |                                                                          |          1 |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Vertebra, Osteosarcoma               |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X                  |          6 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  55                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8|            |
                             DAY ON TEST   | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0|            |
                                           | 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7|     A      |
    18 MG/M3                               | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                  X                    X     X        X   |         13 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X  X        X        X  X                 X  X     X        X   |         23 |
      Mesothelioma Malignant               |                                                                   X      |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  56                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 1| 5| 7| 3| 3| 3| 6| 1| 1| 7| 5| 5| 7| 5| 5| 1| 7| 6| 5| 7| 7|        |            |
                             DAY ON TEST   | 3| 9| 5| 3| 3| 2| 3| 6| 7| 9| 3| 8| 5| 3| 9| 5| 9| 3| 0| 5| 3| 3|        |            |
                                           | 1| 2| 5| 8| 3| 0| 3| 0| 3| 2| 8| 4| 6| 1| 3| 6| 4| 0| 1| 6| 8| 0|        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |     O      |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|        |     T      |
                               ANIMAL ID   | 8| 9| 9| 9| 1| 1| 2| 3| 4| 4| 6| 6| 7| 7| 9| 9| 9| 9| 0| 1| 1| 1|        |     A      |
    CONTROL                                | 9| 0| 2| 9| 4| 5| 0| 8| 1| 6| 4| 6| 0| 2| 2| 3| 4| 5| 9| 2| 6| 7|        |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +     +  +     +        +  M     +        +  +        +  +            |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +     +  +     +        +  +     +        +  +           +            |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +     +  +     +        +  +     +        +  +           +            |  10        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    M     +  +     +        +  +     +        +  +        +  +            |  10        |
      Pheochromocytoma NOS                 |                   X                                                      |          1 |
      Bilateral, Pheochromocytoma Benign   |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +     +  +     +        +  +     +        +  +        A  M            |   9        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M     +  M     +        +  +     +        M  +        M  M            |   6        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      Pars Distalis, Adenoma               |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      C-Cell, Adenoma                      |                                                             X            |          1 |
      Follicle, Adenocarcinoma             |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +     +  +     +        +  M     +        +  +        +  M            |   9        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  57                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 1| 5| 7| 3| 3| 3| 6| 1| 1| 7| 5| 5| 7| 5| 5| 1| 7| 6| 5| 7| 7|        |            |
                             DAY ON TEST   | 3| 9| 5| 3| 3| 2| 3| 6| 7| 9| 3| 8| 5| 3| 9| 5| 9| 3| 0| 5| 3| 3|        |            |
                                           | 1| 2| 5| 8| 3| 0| 3| 0| 3| 2| 8| 4| 6| 1| 3| 6| 4| 0| 1| 6| 8| 0|        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |     O      |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|        |     T      |
                               ANIMAL ID   | 8| 9| 9| 9| 1| 1| 2| 3| 4| 4| 6| 6| 7| 7| 9| 9| 9| 9| 0| 1| 1| 1|        |     A      |
    CONTROL                                | 9| 0| 2| 9| 4| 5| 0| 8| 1| 6| 4| 6| 0| 2| 2| 3| 4| 5| 9| 2| 6| 7|        |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +     +  +     +        +  +     +        +  +        +  M            |  10        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      Bilateral, Interstitial Cell, Adenoma|                               X     X                       X            |          3 |
      Interstitial Cell, Adenoma           |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +     M  M     +        +  +     +        +  +        +  +            |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +     +  +     M        +  +     +        +  +        +  +            |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    M     +  +     +        +  +     +        +  +        +  +            |  10        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +     +  +     M        +  +     +        +  +        +  +            |  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 1| 5| 7| 3| 3| 3| 6| 1| 1| 7| 5| 5| 7| 5| 5| 1| 7| 6| 5| 7| 7|        |            |
                             DAY ON TEST   | 3| 9| 5| 3| 3| 2| 3| 6| 7| 9| 3| 8| 5| 3| 9| 5| 9| 3| 0| 5| 3| 3|        |            |
                                           | 1| 2| 5| 8| 3| 0| 3| 0| 3| 2| 8| 4| 6| 1| 3| 6| 4| 0| 1| 6| 8| 0|        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |     O      |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|        |     T      |
                               ANIMAL ID   | 8| 9| 9| 9| 1| 1| 2| 3| 4| 4| 6| 6| 7| 7| 9| 9| 9| 9| 0| 1| 1| 1|        |     A      |
    CONTROL                                | 9| 0| 2| 9| 4| 5| 0| 8| 1| 6| 4| 6| 0| 2| 2| 3| 4| 5| 9| 2| 6| 7|        |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
   Urinary Bladder                         |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 5| 7| 7| 5| 3| 5| 7| 1| 7| 5| 7| 7| 3| 3| 6| 1| 6| 5| 6| 7|        |            |
                             DAY ON TEST   | 3| 9| 7| 3| 2| 5| 3| 5| 0| 9| 3| 5| 3| 3| 3| 3| 5| 9| 7| 6| 1| 3|        |            |
                                           | 8| 2| 3| 8| 5| 6| 3| 6| 6| 3| 8| 6| 8| 8| 3| 3| 2| 4| 0| 6| 6| 8|        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|        |     T      |
                               ANIMAL ID   | 0| 0| 0| 1| 2| 2| 3| 5| 5| 5| 7| 7| 8| 8| 8| 0| 0| 0| 2| 2| 2| 3|        |     A      |
    6 MG/M3                                | 2| 7| 9| 0| 5| 7| 3| 4| 5| 8| 6| 7| 0| 1| 2| 1| 6| 8| 2| 3| 7| 1|        |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | M  +     M     M  M  M     +  +  +  +  +  +  +     +           +         |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Leukemia Mononuclear                 |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Pheochromocytoma Benign              |                               X     X                                    |          2 |
      Bilateral, Pheochromocytoma Benign   |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M     M     M  M  +     +  +  +  +  +  M  M     M           +         |   7        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +     +  +  +     +  +  +  +  +  +  +     M           +         |  14        |
      Pars Distalis, Adenoma               |                                     X                          X         |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +     +  +  M     +  +  +  +  +  +  +     M           +         |  13        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 5| 7| 7| 5| 3| 5| 7| 1| 7| 5| 7| 7| 3| 3| 6| 1| 6| 5| 6| 7|        |            |
                             DAY ON TEST   | 3| 9| 7| 3| 2| 5| 3| 5| 0| 9| 3| 5| 3| 3| 3| 3| 5| 9| 7| 6| 1| 3|        |            |
                                           | 8| 2| 3| 8| 5| 6| 3| 6| 6| 3| 8| 6| 8| 8| 3| 3| 2| 4| 0| 6| 6| 8|        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|        |     T      |
                               ANIMAL ID   | 0| 0| 0| 1| 2| 2| 3| 5| 5| 5| 7| 7| 8| 8| 8| 0| 0| 0| 2| 2| 2| 3|        |     A      |
    6 MG/M3                                | 2| 7| 9| 0| 5| 7| 3| 4| 5| 8| 6| 7| 0| 1| 2| 1| 6| 8| 2| 3| 7| 1|        |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Bilateral, Interstitial Cell, Adenoma| X        X                    X                                          |          3 |
      Interstitial Cell, Adenoma           |                      X           X     X                                 |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Leukemia Mononuclear                 |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +     +     +  +  M     +  +  +  M  +  +  M     +           +         |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M     +     +  M  +     +  +  +  +  +  M  M     +           +         |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Leukemia Mononuclear                 |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +     +     +  +  +     +  M  +  +  M  +  +     +           +         |  13        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +     M     +  M  +     +  +  +  +  +  +  +     +           M         |  11        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 5| 7| 7| 5| 3| 5| 7| 1| 7| 5| 7| 7| 3| 3| 6| 1| 6| 5| 6| 7|        |            |
                             DAY ON TEST   | 3| 9| 7| 3| 2| 5| 3| 5| 0| 9| 3| 5| 3| 3| 3| 3| 5| 9| 7| 6| 1| 3|        |            |
                                           | 8| 2| 3| 8| 5| 6| 3| 6| 6| 3| 8| 6| 8| 8| 3| 3| 2| 4| 0| 6| 6| 8|        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|        |     T      |
                               ANIMAL ID   | 0| 0| 0| 1| 2| 2| 3| 5| 5| 5| 7| 7| 8| 8| 8| 0| 0| 0| 2| 2| 2| 3|        |     A      |
    6 MG/M3                                | 2| 7| 9| 0| 5| 7| 3| 4| 5| 8| 6| 7| 0| 1| 2| 1| 6| 8| 2| 3| 7| 1|        |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Cortex, Hamartoma                    |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Leukemia Mononuclear                 |                                                                X         |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  62                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 3| 5| 3| 7| 1| 7| 3| 6| 5| 5| 6| 1| 6| 1| 7| 7| 7| 5| 6| 7|        |            |
                             DAY ON TEST   | 5| 3| 3| 5| 3| 0| 9| 2| 3| 2| 6| 1| 2| 9| 5| 9| 3| 3| 3| 5| 5| 1|        |            |
                                           | 7| 1| 3| 6| 3| 4| 2| 4| 3| 7| 8| 0| 9| 3| 1| 4| 0| 8| 8| 6| 1| 8|        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|        |     T      |
                               ANIMAL ID   | 4| 4| 5| 5| 7| 7| 7| 7| 9| 0| 0| 1| 2| 2| 4| 4| 4| 5| 6| 6| 7| 7|        |     A      |
    18 MG/M3                               | 7| 8| 3| 4| 0| 1| 3| 9| 9| 0| 4| 8| 1| 3| 1| 8| 9| 0| 5| 9| 2| 3|        |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +  +     +     +              +     +     +  M  +               |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +  +     +     +              +     +     +  +  +               |  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
      Pheochromocytoma Benign              |          X                                                               |          1 |
      Bilateral, Pheochromocytoma Benign   |                                                    X  X                  |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +  +  +     +     +              +     M     M  +  +               |   8        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +  +     +     +              +     +     +  +  +               |  10        |
      Pars Distalis, Adenoma               |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +     +     +              +     M     M  +  +               |   8        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +  +  I     +     I              +     +     +  +  +               |   8        |
                                            __________________________________________________________________________|____________|
   Prostate                                |       +  +  +     +     +              +     +     +  +  +               |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  63                                                               
NTP Experiment-Test: 05079-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                                TALC                                           Date: 04/07/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:47:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 3| 5| 3| 7| 1| 7| 3| 6| 5| 5| 6| 1| 6| 1| 7| 7| 7| 5| 6| 7|        |            |
                             DAY ON TEST   | 5| 3| 3| 5| 3| 0| 9| 2| 3| 2| 6| 1| 2| 9| 5| 9| 3| 3| 3| 5| 5| 1|        |            |
                                           | 7| 1| 3| 6| 3| 4| 2| 4| 3| 7| 8| 0| 9| 3| 1| 4| 0| 8| 8| 6| 1| 8|        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|        |     T      |
                               ANIMAL ID   | 4| 4| 5| 5| 7| 7| 7| 7| 9| 0| 0| 1| 2| 2| 4| 4| 4| 5| 6| 6| 7| 7|        |     A      |
    18 MG/M3                               | 7| 8| 3| 4| 0| 1| 3| 9| 9| 0| 4| 8| 1| 3| 1| 8| 9| 0| 5| 9| 2| 3|        |     L      |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
      Bilateral, Interstitial Cell, Adenoma|                                                    X                     |          1 |
      Interstitial Cell, Adenoma           |          X                                            X  X               |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       M  +  +     +     +              +     +     +  +  +               |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  +  +     +     +              +     +     +  +  M               |   9        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       M  +  +     +     +              +     +     +  +  +               |   9        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +  +     +     +              +     +     +  +  +               |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +  +     +     +              +     +     +  +  +               |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +  +     +     +              +     +     +  +  +               |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +  +     +     +              +     +     +  +  +               |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +  +     +     +              +     +     M  +  +               |   9        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |       +  +  +     +     +              +     +     +  +  +               |  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  64                                                               
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                                  ----------              END OF REPORT             ----------                                      
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