TDMS Study 05079-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
TALC
NTP Experiment-Test: 05079-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:45
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 14807966
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 22 50 22 50 22
Scheduled Sacrifice 14 18 12
Early Deaths
Moribund Sacrifice 28 5 17 3 27 8
Natural Death 11 2 19 1 14 2
Survivors
Terminal Sacrifice 11 1 13 9
Missing 1
Animals Examined Microscopically 50 15 49 18 50 12
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Ileum (44) (15) (32) (18) (38) (12)
Liver (50) (15) (48) (18) (50) (12)
Granulosa-Theca Tumor Malignant, Metastatic,
Ovary 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Neoplastic Nodule 3 (6%) 1 (2%)
Pancreas (50) (15) (46) (18) (49) (12)
Pharynx (1)
Squamous Cell Carcinoma 1 (100%)
Salivary Glands (50) (15) (48) (18) (50) (12)
Fibrosarcoma 1 (2%)
Sarcoma 1 (2%)
Stomach, Forestomach (50) (15) (45) (17) (49) (12)
Stomach, Glandular (50) (15) (47) (17) (50) (12)
Tongue (2)
Sarcoma, Metastatic 1 (50%)
Squamous Cell Papilloma 1 (50%)
Tooth (1)
Adamantinoma Benign 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (15) (48) (18) (50) (12)
Granulosa-Theca Tumor Malignant, Metastatic,
Ovary 1 (2%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (14) (47) (16) (49) (12)
Granulosa-Theca Tumor Malignant, Metastatic,
Ovary 1 (2%)
Adrenal Gland, Medulla (48) (14) (47) (18) (49) (11)
Granulosa-Theca Tumor Malignant, Metastatic,
Ovary 1 (2%)
Pheochromocytoma Malignant 1 (2%) 7 (14%)
Pheochromocytoma Benign 13 (27%) 10 (21%) 4 (22%) 11 (22%)
Bilateral, Pheochromocytoma Malignant 3 (6%)
Bilateral, Pheochromocytoma Benign 1 (7%) 4 (9%) 1 (6%) 7 (14%) 3 (27%)
Islets, Pancreatic (50) (14) (45) (17) (49) (12)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Parathyroid Gland (43) (12) (42) (15) (47) (8)
Pituitary Gland (50) (15) (47) (18) (50) (12)
Pars Distalis, Adenoma 19 (38%) 4 (27%) 18 (38%) 7 (39%) 21 (42%) 5 (42%)
Pars Distalis, Carcinoma 3 (6%) 1 (7%) 3 (6%) 2 (4%)
Thyroid Gland (50) (13) (47) (18) (49) (11)
Bilateral, C-Cell, Carcinoma 1 (2%)
C-Cell, Adenoma 5 (10%) 1 (8%) 6 (12%)
C-Cell, Carcinoma 2 (4%) 2 (4%) 2 (4%) 1 (9%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (15) (44) (16) (46) (12)
Adenoma 1 (2%)
Carcinoma 2 (4%) 1 (2%)
Ovary (50) (15) (47) (18) (50) (12)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa Cell Tumor Benign 2 (4%)
Granulosa-Theca Tumor Malignant 1 (6%)
Granulosa-Theca Tumor Benign 1 (2%)
Bilateral, Granulosa-Theca Tumor Malignant 1 (2%)
Uterus (50) (15) (48) (18) (50) (12)
Polyp 1 (7%)
Polyp Stromal 5 (10%) 1 (7%) 7 (15%) 1 (6%) 4 (8%) 2 (17%)
Sarcoma Stromal 1 (7%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (15) (43) (18) (49) (12)
Lymph Node (50) (15) (48) (18) (50) (12)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (8%)
Lymph Node, Bronchial (46) (10) (47) (18) (47) (9)
Adenocarcinoma, Metastatic, Thyroid Gland 1 (2%)
Squamous Cell Carcinoma, Metastatic, Lung 1 (2%)
Lymph Node, Mandibular (47) (9) (46) (14) (47) (11)
Sarcoma, Metastatic 1 (2%)
Lymph Node, Mediastinal (47) (11) (44) (17) (47) (12)
Adenocarcinoma, Metastatic, Thyroid Gland 1 (2%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Granulosa-Theca Tumor Malignant, Metastatic,
Ovary 1 (2%)
Lymph Node, Mesenteric (49) (14) (47) (18) (47) (12)
Spleen (50) (15) (48) (18) (50) (12)
Thymus (47) (14) (44) (15) (47) (12)
Mixed Tumor Malignant 1 (2%)
Myxoma 1 (2%)
Schwannoma Benign 1 (2%)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (15) (48) (18) (50) (12)
Adenocarcinoma 2 (4%) 2 (4%)
Adenoma 1 (2%) 2 (13%) 2 (4%) 2 (4%) 1 (8%)
Fibroadenoma 11 (22%) 1 (7%) 10 (21%) 2 (11%) 13 (26%) 1 (8%)
Fibroma 1 (2%) 1 (2%)
Fibrosarcoma 1 (2%)
Skin (50) (15) (49) (18) (50) (12)
Keratoacanthoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (15) (48) (18) (50) (12)
Mandible, Sarcoma 1 (2%)
Mandible, Sarcoma, Metastatic 1 (2%)
Skeletal Muscle (1) (1)
Liposarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (15) (48) (18) (50) (12)
Astrocytoma Benign 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 2 (4%) 1 (2%) 1 (2%)
Ependymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (15) (48) (18) (48) (12)
Adenocarcinoma, Metastatic, Thyroid Gland 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (8%)
Lung (50) (15) (48) (18) (50) (12)
Adenocarcinoma, Multiple, Metastatic,
Mammary Gland 1 (2%)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (6%) 8 (16%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 4 (8%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Granulosa-Theca Tumor Malignant, Metastatic,
Ovary 1 (2%)
Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (15) (47) (18) (49) (12)
Lipoma 1 (2%)
Urinary Bladder (50) (15) (45) (18) (50) (12)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(15) *(49) *(18) *(50) *(12)
Leukemia Mononuclear 13 (26%) 1 (7%) 20 (41%) 1 (6%) 18 (36%)
Lymphoma Malignant Lymphocytic 2 (4%)
Lymphoma Malignant Mixed 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 44 6 47 8 49 7
Total Primary Neoplasms 85 14 100 18 124 13
Total Animals with Benign Neoplasms 38 6 35 8 39 7
Total Benign Neoplasms 59 11 65 16 78 12
Total Animals with Malignant Neoplasms 23 2 31 1 35 1
Total Malignant Neoplasms 26 3 35 2 46 1
Total Animals with Metastatic Neoplasms 4 3 4 1
Total Metastatic Neoplasm 6 8 10 2
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 22 50 22 50 22
Scheduled Sacrifice 11 15 10
Early Deaths
Moribund Sacrifice 23 9 19 5 20 6
Natural Death 18 2 17 2 14 6
Survivors
Terminal Sacrifice 1
Terminal Sacrifice 8 11 13
Natural Death 1 2 3
Animals Examined Microscopically 49 11 50 15 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (42) (11) (38) (15) (37) (10)
Intestine Large, Colon (43) (11) (43) (15) (46) (10)
Intestine Small, Duodenum (48) (11) (44) (15) (46) (10)
Intestine Small, Ileum (39) (11) (34) (15) (35) (10)
Intestine Small, Jejunum (40) (11) (38) (15) (40) (10)
Liver (49) (11) (50) (15) (48) (10)
Neoplastic Nodule 1 (2%)
Neoplastic Nodule, Multiple 2 (4%) 1 (2%) 3 (6%)
Osteosarcoma, Multiple, Metastatic, Bone 1 (2%)
Hepatocyte, Adenoma 1 (2%)
Mesentery (2) (1)
Pancreas (48) (11) (46) (15) (47) (10)
Salivary Glands (49) (11) (50) (15) (50) (10)
Fibroma 1 (2%)
Stomach, Forestomach (49) (10) (47) (15) (47) (10)
Fibrosarcoma 1 (2%)
Stomach, Glandular (49) (10) (47) (15) (47) (10)
Fibrosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (11) (50) (15) (50) (10)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (11) (49) (15) (48) (10)
Adrenal Gland, Medulla (49) (10) (48) (15) (47) (10)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Pheochromocytoma Malignant 2 (4%) 3 (6%) 6 (13%)
Pheochromocytoma NOS 1 (10%)
Pheochromocytoma Complex 2 (4%) 1 (2%)
Pheochromocytoma Benign 13 (27%) 9 (19%) 2 (13%) 20 (43%) 1 (10%)
Bilateral, Pheochromocytoma Malignant 1 (2%) 1 (2%)
Bilateral, Pheochromocytoma Benign 12 (24%) 1 (10%) 21 (44%) 1 (7%) 16 (34%) 2 (20%)
Islets, Pancreatic (47) (9) (41) (15) (43) (10)
Adenoma 1 (2%) 2 (5%)
Carcinoma 1 (2%)
Parathyroid Gland (45) (6) (45) (7) (46) (8)
Adenoma 1 (2%)
Pituitary Gland (47) (11) (50) (14) (49) (10)
Pars Distalis, Adenoma 12 (26%) 1 (9%) 11 (22%) 2 (14%) 10 (20%) 1 (10%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 2 (4%)
Thyroid Gland (45) (11) (46) (13) (46) (8)
C-Cell, Adenoma 3 (7%) 1 (9%) 4 (9%) 3 (7%)
C-Cell, Carcinoma 1 (2%)
Follicle, Adenocarcinoma 1 (9%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (9) (50) (15) (49) (10)
Preputial Gland (48) (11) (49) (15) (48) (8)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 1 (2%) 6 (12%) 1 (2%)
Prostate (49) (10) (45) (15) (48) (10)
Seminal Vesicle (49) (11) (48) (15) (47) (10)
Testes (49) (11) (50) (15) (50) (10)
Bilateral, Interstitial Cell, Adenoma 18 (37%) 3 (27%) 24 (48%) 3 (20%) 24 (48%) 1 (10%)
Interstitial Cell, Adenoma 13 (27%) 1 (9%) 15 (30%) 3 (20%) 12 (24%) 3 (30%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (11) (48) (15) (47) (10)
Lymph Node (49) (11) (50) (15) (50) (10)
Lymph Node, Bronchial (41) (9) (48) (15) (49) (10)
Lymph Node, Mandibular (46) (10) (48) (12) (47) (9)
Lymph Node, Mediastinal (48) (11) (49) (11) (47) (10)
Lymph Node, Mesenteric (49) (10) (48) (15) (47) (10)
Spleen (49) (11) (50) (15) (48) (10)
Fibrosarcoma 1 (2%)
Fibrous Histiocytoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Thymus (48) (11) (40) (13) (43) (9)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (45) (10) (48) (11) (50) (9)
Adenocarcinoma 1 (2%)
Skin (48) (11) (50) (15) (50) (10)
Basosquamous Tumor Malignant 1 (2%)
Fibroma 2 (4%)
Fibrous Histiocytoma 1 (2%)
Keratoacanthoma 2 (4%) 2 (4%)
Neurofibroma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (11) (50) (15) (50) (10)
Pelvis, Osteosarcoma 1 (2%)
Scapula, Osteosarcoma 1 (2%)
Vertebra, Osteosarcoma 1 (2%)
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (11) (50) (15) (50) (10)
Astrocytoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (11) (50) (15) (50) (10)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Osteosarcoma, Multiple, Metastatic, Bone 1 (2%)
Osteosarcoma, Metastatic 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Schwannoma Malignant, Metastatic 1 (2%)
Nose (49) (11) (48) (15) (47) (10)
Chondroma 1 (2%)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (11) (49) (15) (48) (10)
Cortex, Hamartoma 1 (7%)
Renal Tubule, Carcinoma 2 (4%)
Urinary Bladder (49) (11) (48) (15) (47) (9)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(49) *(11) *(50) *(15) *(50) *(10)
Leukemia Mononuclear 24 (49%) 21 (42%) 1 (7%) 23 (46%)
Lymphoma Malignant Lymphocytic 1 (2%)
Mesothelioma Benign 1 (2%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 7 49 8 50 4
Total Primary Neoplasms 116 9 135 13 137 8
Total Animals with Benign Neoplasms 42 5 45 8 45 4
Total Benign Neoplasms 78 7 96 12 98 8
Total Animals with Malignant Neoplasms 34 1 33 1 33
Total Malignant Neoplasms 38 1 39 1 39
Total Animals with Metastatic Neoplasms 2 2 1
Total Metastatic Neoplasm 4 2 2
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
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