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TDMS Study 05079-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                                TALC


NTP Experiment-Test: 05079-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:45




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  14807966

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05079-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           22           50           22           50           22           
  Scheduled Sacrifice                                              14                        18                        12           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                28            5           17            3           27            8           
    Natural Death                                     11            2           19            1           14            2           
  Survivors                                                                                                                         
    Terminal Sacrifice                                11            1           13                         9                        
  Missing                                                                        1                                                  
  Animals Examined Microscopically                    50           15           49           18           50           12           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Ileum                             (44)         (15)         (32)         (18)         (38)         (12)         
   Liver                                              (50)         (15)         (48)         (18)         (50)         (12)         
      Granulosa-Theca Tumor Malignant, Metastatic,                                                                                  
           Ovary                                                                                           1 (2%)                   
      Hepatocellular Carcinoma                                                   1 (2%)                                             
      Neoplastic Nodule                                                          3 (6%)                    1 (2%)                   
   Pancreas                                           (50)         (15)         (46)         (18)         (49)         (12)         
   Pharynx                                                                                                (1)                       
      Squamous Cell Carcinoma                                                                              1 (100%)                 
   Salivary Glands                                    (50)         (15)         (48)         (18)         (50)         (12)         
      Fibrosarcoma                                                                                         1 (2%)                   
      Sarcoma                                                                    1 (2%)                                             
   Stomach, Forestomach                               (50)         (15)         (45)         (17)         (49)         (12)         
   Stomach, Glandular                                 (50)         (15)         (47)         (17)         (50)         (12)         
   Tongue                                                                       (2)                                                 
      Sarcoma, Metastatic                                                        1 (50%)                                            
      Squamous Cell Papilloma                                                    1 (50%)                                            
   Tooth                                                                        (1)                                                 
      Adamantinoma Benign                                                        1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (15)         (48)         (18)         (50)         (12)         
      Granulosa-Theca Tumor Malignant, Metastatic,                                                                                  
           Ovary                                                                                           1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05079-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (14)         (47)         (16)         (49)         (12)         
      Granulosa-Theca Tumor Malignant, Metastatic,                                                                                  
           Ovary                                                                                           1 (2%)                   
   Adrenal Gland, Medulla                             (48)         (14)         (47)         (18)         (49)         (11)         
      Granulosa-Theca Tumor Malignant, Metastatic,                                                                                  
           Ovary                                                                                           1 (2%)                   
      Pheochromocytoma Malignant                                                 1 (2%)                    7 (14%)                  
      Pheochromocytoma Benign                         13 (27%)                  10 (21%)      4 (22%)     11 (22%)                  
      Bilateral, Pheochromocytoma Malignant                                                                3 (6%)                   
      Bilateral, Pheochromocytoma Benign                            1 (7%)       4 (9%)       1 (6%)       7 (14%)      3 (27%)     
   Islets, Pancreatic                                 (50)         (14)         (45)         (17)         (49)         (12)         
      Adenoma                                          1 (2%)                    1 (2%)                    1 (2%)                   
   Parathyroid Gland                                  (43)         (12)         (42)         (15)         (47)         (8)          
   Pituitary Gland                                    (50)         (15)         (47)         (18)         (50)         (12)         
      Pars Distalis, Adenoma                          19 (38%)      4 (27%)     18 (38%)      7 (39%)     21 (42%)      5 (42%)     
      Pars Distalis, Carcinoma                         3 (6%)       1 (7%)       3 (6%)                    2 (4%)                   
   Thyroid Gland                                      (50)         (13)         (47)         (18)         (49)         (11)         
      Bilateral, C-Cell, Carcinoma                     1 (2%)                                                                       
      C-Cell, Adenoma                                  5 (10%)      1 (8%)                                 6 (12%)                  
      C-Cell, Carcinoma                                2 (4%)                    2 (4%)                    2 (4%)       1 (9%)      
      Follicular Cell, Adenoma                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (15)         (44)         (16)         (46)         (12)         
      Adenoma                                                                                              1 (2%)                   
      Carcinoma                                        2 (4%)                                              1 (2%)                   
   Ovary                                              (50)         (15)         (47)         (18)         (50)         (12)         
      Granulosa Cell Tumor Malignant                   1 (2%)                                                                       
      Granulosa Cell Tumor Benign                                                2 (4%)                                             
      Granulosa-Theca Tumor Malignant                                                         1 (6%)                                
      Granulosa-Theca Tumor Benign                                               1 (2%)                                             
      Bilateral, Granulosa-Theca Tumor Malignant                                                           1 (2%)                   
   Uterus                                             (50)         (15)         (48)         (18)         (50)         (12)         
      Polyp                                                         1 (7%)                                                          
      Polyp Stromal                                    5 (10%)      1 (7%)       7 (15%)      1 (6%)       4 (8%)       2 (17%)     
      Sarcoma Stromal                                               1 (7%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05079-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (15)         (43)         (18)         (49)         (12)         
   Lymph Node                                         (50)         (15)         (48)         (18)         (50)         (12)         
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                                                                                 1 (8%)      
   Lymph Node, Bronchial                              (46)         (10)         (47)         (18)         (47)         (9)          
      Adenocarcinoma, Metastatic, Thyroid Gland        1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Lung                                                            1 (2%)                   
   Lymph Node, Mandibular                             (47)         (9)          (46)         (14)         (47)         (11)         
      Sarcoma, Metastatic                                                        1 (2%)                                             
   Lymph Node, Mediastinal                            (47)         (11)         (44)         (17)         (47)         (12)         
      Adenocarcinoma, Metastatic, Thyroid Gland        1 (2%)                                                                       
      Carcinoma, Metastatic, Uncertain Primary Site                                                        1 (2%)                   
      Fibrosarcoma, Metastatic, Skin                                                                       1 (2%)                   
      Granulosa-Theca Tumor Malignant, Metastatic,                                                                                  
           Ovary                                                                                           1 (2%)                   
   Lymph Node, Mesenteric                             (49)         (14)         (47)         (18)         (47)         (12)         
   Spleen                                             (50)         (15)         (48)         (18)         (50)         (12)         
   Thymus                                             (47)         (14)         (44)         (15)         (47)         (12)         
      Mixed Tumor Malignant                                                      1 (2%)                                             
      Myxoma                                                                     1 (2%)                                             
      Schwannoma Benign                                                                                    1 (2%)                   
      Thymoma Benign                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (15)         (48)         (18)         (50)         (12)         
      Adenocarcinoma                                   2 (4%)                                              2 (4%)                   
      Adenoma                                          1 (2%)       2 (13%)      2 (4%)                    2 (4%)       1 (8%)      
      Fibroadenoma                                    11 (22%)      1 (7%)      10 (21%)      2 (11%)     13 (26%)      1 (8%)      
      Fibroma                                          1 (2%)                    1 (2%)                                             
      Fibrosarcoma                                                                                         1 (2%)                   
   Skin                                               (50)         (15)         (49)         (18)         (50)         (12)         
      Keratoacanthoma                                                            1 (2%)                    1 (2%)                   
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (15)         (48)         (18)         (50)         (12)         
      Mandible, Sarcoma                                1 (2%)                                                                       
      Mandible, Sarcoma, Metastatic                                              1 (2%)                                             
   Skeletal Muscle                                    (1)                       (1)                                                 
      Liposarcoma                                                                1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05079-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (15)         (48)         (18)         (50)         (12)         
      Astrocytoma Benign                               1 (2%)                                                                       
      Carcinoma, Metastatic, Pituitary Gland           2 (4%)                    1 (2%)                    1 (2%)                   
      Ependymoma Malignant                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (15)         (48)         (18)         (48)         (12)         
      Adenocarcinoma, Metastatic, Thyroid Gland        1 (2%)                                                                       
      Carcinoma, Metastatic, Thyroid Gland                                                                              1 (8%)      
   Lung                                               (50)         (15)         (48)         (18)         (50)         (12)         
      Adenocarcinoma, Multiple, Metastatic,                                                                                         
          Mammary Gland                                1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                 1 (6%)       8 (16%)                  
      Alveolar/Bronchiolar Adenoma, Multiple                                                               1 (2%)                   
      Alveolar/Bronchiolar Carcinoma                                                                       4 (8%)                   
      Alveolar/Bronchiolar Carcinoma, Multiple                                                             1 (2%)                   
      Granulosa-Theca Tumor Malignant, Metastatic,                                                                                  
           Ovary                                                                                           1 (2%)                   
      Squamous Cell Carcinoma                                                                              1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (15)         (47)         (18)         (49)         (12)         
      Lipoma                                                                     1 (2%)                                             
   Urinary Bladder                                    (50)         (15)         (45)         (18)         (50)         (12)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(15)        *(49)        *(18)        *(50)        *(12)         
      Leukemia Mononuclear                            13 (26%)      1 (7%)      20 (41%)      1 (6%)      18 (36%)                  
      Lymphoma Malignant Lymphocytic                                             2 (4%)                                             
      Lymphoma Malignant Mixed                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05079-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            44           6          47           8          49           7               
     Total Primary Neoplasms                           85          14         100          18         124          13               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 38           6          35           8          39           7               
     Total Benign Neoplasms                            59          11          65          16          78          12               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23           2          31           1          35           1               
     Total Malignant Neoplasms                         26           3          35           2          46           1               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4                       3                       4           1               
     Total Metastatic Neoplasm                          6                       8                      10           2               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                               1                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05079-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           22           50           22           50           22           
  Scheduled Sacrifice                                              11                        15                        10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23            9           19            5           20            6           
    Natural Death                                     18            2           17            2           14            6           
  Survivors                                                                                                                         
    Terminal Sacrifice                                                           1                                                  
    Terminal Sacrifice                                 8                        11                        13                        
    Natural Death                                      1                         2                         3                        
  Animals Examined Microscopically                    49           11           50           15           50           10           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (42)         (11)         (38)         (15)         (37)         (10)         
   Intestine Large, Colon                             (43)         (11)         (43)         (15)         (46)         (10)         
   Intestine Small, Duodenum                          (48)         (11)         (44)         (15)         (46)         (10)         
   Intestine Small, Ileum                             (39)         (11)         (34)         (15)         (35)         (10)         
   Intestine Small, Jejunum                           (40)         (11)         (38)         (15)         (40)         (10)         
   Liver                                              (49)         (11)         (50)         (15)         (48)         (10)         
      Neoplastic Nodule                                                                                    1 (2%)                   
      Neoplastic Nodule, Multiple                      2 (4%)                    1 (2%)                    3 (6%)                   
      Osteosarcoma, Multiple, Metastatic, Bone         1 (2%)                                                                       
      Hepatocyte, Adenoma                                                        1 (2%)                                             
   Mesentery                                          (2)                                                 (1)                       
   Pancreas                                           (48)         (11)         (46)         (15)         (47)         (10)         
   Salivary Glands                                    (49)         (11)         (50)         (15)         (50)         (10)         
      Fibroma                                                                    1 (2%)                                             
   Stomach, Forestomach                               (49)         (10)         (47)         (15)         (47)         (10)         
      Fibrosarcoma                                                                                         1 (2%)                   
   Stomach, Glandular                                 (49)         (10)         (47)         (15)         (47)         (10)         
      Fibrosarcoma                                                                                         1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (11)         (50)         (15)         (50)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05079-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (11)         (49)         (15)         (48)         (10)         
   Adrenal Gland, Medulla                             (49)         (10)         (48)         (15)         (47)         (10)         
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                                             1 (2%)                   
      Pheochromocytoma Malignant                       2 (4%)                    3 (6%)                    6 (13%)                  
      Pheochromocytoma NOS                                          1 (10%)                                                         
      Pheochromocytoma Complex                                                   2 (4%)                    1 (2%)                   
      Pheochromocytoma Benign                         13 (27%)                   9 (19%)      2 (13%)     20 (43%)      1 (10%)     
      Bilateral, Pheochromocytoma Malignant            1 (2%)                                              1 (2%)                   
      Bilateral, Pheochromocytoma Benign              12 (24%)      1 (10%)     21 (44%)      1 (7%)      16 (34%)      2 (20%)     
   Islets, Pancreatic                                 (47)         (9)          (41)         (15)         (43)         (10)         
      Adenoma                                          1 (2%)                                              2 (5%)                   
      Carcinoma                                        1 (2%)                                                                       
   Parathyroid Gland                                  (45)         (6)          (45)         (7)          (46)         (8)          
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (47)         (11)         (50)         (14)         (49)         (10)         
      Pars Distalis, Adenoma                          12 (26%)      1 (9%)      11 (22%)      2 (14%)     10 (20%)      1 (10%)     
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
      Pars Intermedia, Adenoma                                                                             2 (4%)                   
   Thyroid Gland                                      (45)         (11)         (46)         (13)         (46)         (8)          
      C-Cell, Adenoma                                  3 (7%)       1 (9%)       4 (9%)                    3 (7%)                   
      C-Cell, Carcinoma                                                          1 (2%)                                             
      Follicle, Adenocarcinoma                                      1 (9%)                                                          
      Follicular Cell, Adenoma                                                                             1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                       (1)                                                 
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                          1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (9)          (50)         (15)         (49)         (10)         
   Preputial Gland                                    (48)         (11)         (49)         (15)         (48)         (8)          
      Adenoma                                          1 (2%)                    1 (2%)                    1 (2%)                   
      Carcinoma                                        1 (2%)                    6 (12%)                   1 (2%)                   
   Prostate                                           (49)         (10)         (45)         (15)         (48)         (10)         
   Seminal Vesicle                                    (49)         (11)         (48)         (15)         (47)         (10)         
   Testes                                             (49)         (11)         (50)         (15)         (50)         (10)         
      Bilateral, Interstitial Cell, Adenoma           18 (37%)      3 (27%)     24 (48%)      3 (20%)     24 (48%)      1 (10%)     
      Interstitial Cell, Adenoma                      13 (27%)      1 (9%)      15 (30%)      3 (20%)     12 (24%)      3 (30%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05079-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (11)         (48)         (15)         (47)         (10)         
   Lymph Node                                         (49)         (11)         (50)         (15)         (50)         (10)         
   Lymph Node, Bronchial                              (41)         (9)          (48)         (15)         (49)         (10)         
   Lymph Node, Mandibular                             (46)         (10)         (48)         (12)         (47)         (9)          
   Lymph Node, Mediastinal                            (48)         (11)         (49)         (11)         (47)         (10)         
   Lymph Node, Mesenteric                             (49)         (10)         (48)         (15)         (47)         (10)         
   Spleen                                             (49)         (11)         (50)         (15)         (48)         (10)         
      Fibrosarcoma                                     1 (2%)                                                                       
      Fibrous Histiocytoma                                                       1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Thymus                                             (48)         (11)         (40)         (13)         (43)         (9)          
      Thymoma Malignant                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (10)         (48)         (11)         (50)         (9)          
      Adenocarcinoma                                   1 (2%)                                                                       
   Skin                                               (48)         (11)         (50)         (15)         (50)         (10)         
      Basosquamous Tumor Malignant                                                                         1 (2%)                   
      Fibroma                                                                    2 (4%)                                             
      Fibrous Histiocytoma                                                                                 1 (2%)                   
      Keratoacanthoma                                                            2 (4%)                    2 (4%)                   
      Neurofibroma                                                               1 (2%)                                             
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                               1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (11)         (50)         (15)         (50)         (10)         
      Pelvis, Osteosarcoma                                                       1 (2%)                                             
      Scapula, Osteosarcoma                            1 (2%)                                                                       
      Vertebra, Osteosarcoma                                                                               1 (2%)                   
   Skeletal Muscle                                    (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (11)         (50)         (15)         (50)         (10)         
      Astrocytoma Malignant                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05079-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (11)         (50)         (15)         (50)         (10)         
      Alveolar/Bronchiolar Adenoma                                               1 (2%)                    1 (2%)                   
      Alveolar/Bronchiolar Carcinoma, Multiple                                                             1 (2%)                   
      Osteosarcoma, Multiple, Metastatic, Bone         1 (2%)                                                                       
      Osteosarcoma, Metastatic                                                   1 (2%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                                             1 (2%)                   
      Schwannoma Malignant, Metastatic                 1 (2%)                                                                       
   Nose                                               (49)         (11)         (48)         (15)         (47)         (10)         
      Chondroma                                        1 (2%)                                                                       
      Sarcoma                                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (11)         (49)         (15)         (48)         (10)         
      Cortex, Hamartoma                                                                       1 (7%)                                
      Renal Tubule, Carcinoma                          2 (4%)                                                                       
   Urinary Bladder                                    (49)         (11)         (48)         (15)         (47)         (9)          
      Papilloma                                        1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(49)        *(11)        *(50)        *(15)        *(50)        *(10)         
      Leukemia Mononuclear                            24 (49%)                  21 (42%)      1 (7%)      23 (46%)                  
      Lymphoma Malignant Lymphocytic                   1 (2%)                                                                       
      Mesothelioma Benign                              1 (2%)                                                                       
      Mesothelioma Malignant                                                                               1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05079-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                                TALC                                           Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:45  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      CONTROL      6 MG/M3      6 MG/M3      18 MG/M3     18 MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48           7          49           8          50           4               
     Total Primary Neoplasms                          116           9         135          13         137           8               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 42           5          45           8          45           4               
     Total Benign Neoplasms                            78           7          96          12          98           8               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              34           1          33           1          33                           
     Total Malignant Neoplasms                         38           1          39           1          39                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       2                       1                           
     Total Metastatic Neoplasm                          4                       2                       2                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                               1                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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