Share This:
https://ntp.niehs.nih.gov/go/2511

TDMS Study 05080-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                        ALLYL GLYCIDYL ETHER


NTP Experiment-Test: 05080-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17




       Facility:  Battelle Northwest

       Chemical CAS #:  106-92-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                              10            3            6                                                  
    Moribund                                           7            5            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           41           41                                                  
    Dead                                                            1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (6)          (42)                                                
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
   Intestine Large, Colon                             (49)         (9)          (49)                                                
      Hyperplasia, Lymphoid                                                      2 (4%)                                             
   Intestine Small, Ileum                             (47)         (7)          (47)                                                
      Hyperplasia, Lymphoid                            1 (2%)                    3 (6%)                                             
   Liver                                              (50)         (15)         (50)                                                
      Basophilic Focus                                              1 (7%)                                                          
      Cyst                                                          2 (13%)                                                         
      Focal Cellular Change                                                      1 (2%)                                             
      Hematopoietic Cell Proliferation                 2 (4%)       1 (7%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Inflammation, Chronic, Multifocal                4 (8%)                    1 (2%)                                             
      Leukocytosis                                     1 (2%)                                                                       
      Hepatocyte, Cytomegaly                           1 (2%)                                                                       
   Mesentery                                          (13)         (4)          (8)                                                 
      Hyperplasia, Lymphoid                            2 (15%)                   2 (25%)                                            
      Inflammation, Chronic                                         1 (25%)                                                         
      Inflammation, Suppurative                        2 (15%)                                                                      
      Fat, Necrosis                                    1 (8%)       1 (25%)      1 (13%)                                            
   Pancreas                                           (49)         (10)         (50)                                                
      Atrophy                                          3 (6%)       1 (10%)      1 (2%)                                             
      Cyst                                                          1 (10%)      1 (2%)                                             
      Hyperplasia, Lymphoid                            2 (4%)       1 (10%)                                                         
      Inflammation, Chronic                                         1 (10%)                                                         
      Duct, Ectasia                                    1 (2%)                                                                       
   Salivary Glands                                    (50)         (9)          (50)                                                
      Hyperplasia, Lymphoid                            1 (2%)                    2 (4%)                                             
      Inflammation, Chronic, Multifocal                2 (4%)       1 (11%)      1 (2%)                                             
   Stomach, Forestomach                               (50)         (12)         (49)                                                
      Granuloma                                        1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperkeratosis                                   1 (2%)       1 (8%)       2 (4%)                                             
      Hyperplasia                                      1 (2%)       1 (8%)       2 (4%)                                             
      Hyperplasia, Squamous                            1 (2%)                                                                       
      Ulcer                                                                      2 (4%)                                             
   Stomach, Glandular                                 (49)         (10)         (48)                                                
      Atrophy                                          1 (2%)                    2 (4%)                                             
      Atrophy, Focal                                                1 (10%)                                                         
      Cyst                                             1 (2%)                                                                       
   Tooth                                              (3)                       (1)                                                 
      Peridontal Tissue, Inflammation, Chronic         1 (33%)                   1 (100%)                                           
      Peridontal Tissue, Inflammation, Suppurative     2 (67%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (49)         (9)          (50)                                                
      Inflammation, Acute                              1 (2%)                                                                       
   Heart                                              (50)         (9)          (50)                                                
      Fibrosis, Focal                                  1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Atrium, Inflammation, Focal, Suppurative         1 (2%)                                                                       
      Myocardium, Inflammation, Chronic                             1 (11%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (47)         (9)          (48)                                                
      Subcapsular, Hyperplasia                        42 (89%)      8 (89%)     46 (96%)                                            
   Adrenal Gland, Cortex                              (47)         (8)          (48)                                                
      Accessory Adrenal Cortical Nodule                2 (4%)                    1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
      Degeneration                                    37 (79%)      5 (63%)     40 (83%)                                            
      Fibrosis                                        36 (77%)      5 (63%)     40 (83%)                                            
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
   Adrenal Gland, Medulla                             (47)         (7)          (47)                                                
      Cyst                                                                       1 (2%)                                             
   Pituitary Gland                                    (44)         (17)         (45)                                                
      Pars Distalis, Cyst                              1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      15 (34%)      6 (35%)      9 (20%)                                            
   Thyroid Gland                                      (50)         (10)         (50)                                                
      C-Cell, Hyperplasia                              1 (2%)                    1 (2%)                                             
      Follicle, Degeneration                           1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     3 (6%)       1 (10%)      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (5)                       (1)                                                 
      Abscess                                          1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (19)         (50)                                                
      Atrophy                                                                    1 (2%)                                             
      Cyst                                            14 (29%)     10 (53%)     18 (36%)                                            
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                        4 (8%)       3 (16%)      2 (4%)                                             
      Capsule, Fibrosis                                                          1 (2%)                                             
      Capsule, Inflammation, Chronic                                             1 (2%)                                             
      Capsule, Mineralization                                                    1 (2%)                                             
   Uterus                                             (50)         (24)         (50)                                                
      Endometrium, Hyperplasia, Cystic                36 (72%)     22 (92%)     29 (58%)                                            
      Endometrium, Inflammation, Acute                 1 (2%)                                                                       
      Endometrium, Inflammation, Suppurative           3 (6%)       2 (8%)       1 (2%)                                             
      Endometrium, Necrosis                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (49)         (9)          (50)                                                
      Leukocytosis                                     1 (2%)                                                                       
   Bone Marrow                                        (50)         (35)         (48)                                                
      Hyperplasia                                      1 (2%)                                                                       
      Myelofibrosis                                   36 (72%)     32 (91%)     45 (94%)                                            
   Lymph Node                                         (48)         (11)         (48)                                                
      Mesenteric, Hyperplasia, Lymphoid                1 (2%)                                                                       
      Renal, Hyperplasia, Lymphoid                                               1 (2%)                                             
      Renal, Inflammation, Suppurative                 1 (2%)                                                                       
   Lymph Node, Bronchial                              (38)         (7)          (37)                                                
      Hyperplasia, Lymphoid                            1 (3%)                    5 (14%)                                            
   Lymph Node, Mandibular                             (42)         (6)          (40)                                                
      Cyst                                             1 (2%)                                                                       
      Hyperplasia, Lymphoid                            8 (19%)                   8 (20%)                                            
      Infiltration Cellular, Histiocyte                             1 (17%)                                                         
      Inflammation, Suppurative                        1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
   Spleen                                             (50)         (18)         (50)                                                
      Atrophy                                          1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 6 (12%)      3 (17%)      4 (8%)                                             
      Hyperplasia, Lymphoid                            8 (16%)      1 (6%)      10 (20%)                                            
   Thymus                                             (34)         (8)          (42)                                                
      Atrophy                                          1 (3%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                            1 (3%)                    1 (2%)                                             
      Inflammation, Necrotizing                        1 (3%)                                                                       
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mediastinum, Inflammation, Suppurative           1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (18)         (50)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Hair Follicle, Atrophy                           5 (10%)      8 (44%)      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (9)          (50)                                                
      Cranium, Fibrous Osteodystrophy                                            1 (2%)                                             
   Skeletal Muscle                                    (1)          (1)          (2)                                                 
      Back, Inflammation, Chronic                                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (9)          (50)                                                
      Hypothalamus, Atrophy                            5 (10%)                   1 (2%)                                             
      Lateral Ventricle, Dilatation                    1 (2%)                                                                       
      Thalamus, Mineralization                         5 (10%)      1 (11%)      4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (9)          (50)                                                
      Epithelium, Hyperplasia, Focal                   1 (2%)                                                                       
   Lung                                               (50)         (9)          (50)                                                
      Hyperplasia, Lymphoid                            3 (6%)                    5 (10%)                                            
      Infiltration Cellular, Diffuse, Histiocyte                                 1 (2%)                                             
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Inflammation, Chronic, Multifocal               17 (34%)      2 (22%)     24 (48%)                                            
      Leukocytosis                                     2 (4%)       1 (11%)      1 (2%)                                             
      Alveolus, Granuloma                                                        1 (2%)                                             
      Bronchiole, Hyperplasia                          1 (2%)                                                                       
   Nose                                               (49)         (49)         (50)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Glands, Hyperplasia                             32 (65%)     46 (94%)     49 (98%)                                            
      Glands, Inflammation                                          1 (2%)                                                          
      Glands, Regeneration                                          1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Mucosa, Inflammation                             1 (2%)                                                                       
      Mucosa, Inflammation, Acute                      1 (2%)                                                                       
      Mucosa, Inflammation, Suppurative                8 (16%)     48 (98%)     49 (98%)                                            
      Olfactory Epithelium, Metaplasia                 7 (14%)     48 (98%)     49 (98%)                                            
      Respiratory Epithelium, Dysplasia                                          3 (6%)                                             
      Respiratory Epithelium, Hyperplasia                          39 (80%)     48 (96%)                                            
      Respiratory Epithelium, Hyperplasia, Basal                                                                                    
          Cell                                                      2 (4%)       7 (14%)                                            
      Respiratory Epithelium, Metaplasia, Squamous                  9 (18%)     12 (24%)                                            
      Respiratory Epithelium, Regeneration             5 (10%)     47 (96%)     46 (92%)                                            
      Submucosa, Angiectasis, Focal                                              2 (4%)                                             
   Trachea                                            (50)         (9)          (49)                                                
      Metaplasia, Focal, Squamous                                                1 (2%)                                             
      Glands, Inflammation, Suppurative                1 (2%)                                                                       
      Mediastinum, Inflammation, Suppurative           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                       (2)                                                 
      Inflammation, Necrotizing                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)         (49)                                                
      Hyperplasia, Lymphoid                            4 (8%)                    1 (2%)                                             
      Inflammation, Chronic                           10 (20%)      3 (30%)     18 (37%)                                            
      Inflammation, Suppurative                        2 (4%)       1 (10%)                                                         
      Metaplasia, Focal, Osseous                                                 2 (4%)                                             
      Regeneration                                                               1 (2%)                                             
      Cortex, Cyst                                                  1 (10%)                                                         
      Cortex, Infarct                                  1 (2%)                                                                       
      Renal Tubule, Necrosis                                        1 (10%)                                                         
      Renal Tubule, Regeneration                       5 (10%)                   5 (10%)                                            
      Renal Tubule, Regeneration, Focal                1 (2%)                                                                       
   Urinary Bladder                                    (47)         (9)          (47)                                                
      Hyperplasia, Lymphoid                            3 (6%)                    4 (9%)                                             
      Inflammation, Chronic                           10 (21%)      3 (33%)      6 (13%)                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               7            2            1                                                  
    Moribund                                           5            9            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           39           46                                                  
    Moribund                                           1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (45)         (5)          (48)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
   Intestine Large, Colon                             (47)         (10)         (49)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Large, Rectum                            (47)         (10)         (47)                                                
      Inflammation, Suppurative                        2 (4%)                                                                       
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Small                                    (45)         (13)         (49)                                                
      Lymphoid Tissue, Hyperplasia                     1 (2%)                                                                       
   Intestine Small, Ileum                             (45)         (11)         (49)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Submucosa, Amyloid Deposition                    1 (2%)                                                                       
   Liver                                              (49)         (19)         (49)                                                
      Basophilic Focus                                              1 (5%)                                                          
      Cyst, Multiple                                                1 (5%)                                                          
      Developmental Malformation                       1 (2%)                                                                       
      Focal Cellular Change                            2 (4%)                    2 (4%)                                             
      Inflammation, Acute, Focal                                                 1 (2%)                                             
      Inflammation, Chronic, Multifocal                             1 (5%)       2 (4%)                                             
      Necrosis, Coagulative                            1 (2%)                    1 (2%)                                             
      Proliferation Connective Tissue                               1 (5%)                                                          
      Bile Duct, Cyst                                                            1 (2%)                                             
      Centrilobular, Fatty Change, Multifocal          1 (2%)                                                                       
      Serosa, Fibrosis                                 1 (2%)                                                                       
   Mesentery                                          (2)                       (1)                                                 
      Inflammation, Chronic                            1 (50%)                                                                      
   Pancreas                                           (49)         (12)         (49)                                                
      Cyst                                                          1 (8%)                                                          
      Fibrosis, Diffuse                                1 (2%)                                                                       
   Salivary Glands                                    (49)         (10)         (49)                                                
      Inflammation, Chronic                            2 (4%)                    4 (8%)                                             
   Stomach, Forestomach                               (50)         (15)         (49)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperkeratosis                                   3 (6%)       1 (7%)       1 (2%)                                             
      Hyperplasia, Squamous                                         1 (7%)                                                          
      Mineralization, Focal                            1 (2%)                                                                       
      Ulcer                                                         2 (13%)      2 (4%)                                             
   Stomach, Glandular                                 (50)         (15)         (49)                                                
      Atrophy                                          1 (2%)                                                                       
      Atrophy, Diffuse                                 1 (2%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Dysplasia, Focal                                 1 (2%)                                                                       
      Necrosis, Multifocal                             1 (2%)                                                                       
      Ulcer, Multiple                                               1 (7%)                                                          
   Tooth                                              (3)          (3)          (3)                                                 
      Abscess                                                       3 (100%)                                                        
      Developmental Malformation                       2 (67%)                                                                      
      Inflammation, Chronic, Focal                     1 (33%)                                                                      
      Peridontal Tissue, Inflammation, Chronic                                   3 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (11)         (50)                                                
      Atrium, Thrombosis                               1 (2%)                                                                       
      Coronary Artery, Inflammation, Chronic, Focal    1 (2%)                                                                       
      Myocardium, Inflammation, Acute, Focal                                     1 (2%)                                             
      Myocardium, Inflammation, Chronic                                          2 (4%)                                             
      Valve, Inflammation, Chronic, Focal              1 (2%)                                                                       
      Valve, Pigmentation, Focal                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (11)         (50)                                                
      Subcapsular, Hyperplasia                        46 (94%)     10 (91%)     49 (98%)                                            
   Adrenal Gland, Cortex                              (49)         (11)         (49)                                                
      Accessory Adrenal Cortical Nodule                                          1 (2%)                                             
      Degeneration, Focal                              2 (4%)                                                                       
      Hyperplasia, Focal                                                         2 (4%)                                             
      Hypertrophy, Focal                               1 (2%)                    1 (2%)                                             
   Pituitary Gland                                    (44)         (9)          (49)                                                
      Cyst                                                                       1 (2%)                                             
   Thyroid Gland                                      (50)         (10)         (49)                                                
      Follicular Cell, Hyperplasia                     4 (8%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Penis                                              (1)          (2)                                                              
      Inflammation, Necrotizing                        1 (100%)     1 (50%)                                                         
   Preputial Gland                                    (8)          (9)          (8)                                                 
      Cyst                                             2 (25%)      4 (44%)      5 (63%)                                            
      Cyst, Multiple                                                             1 (13%)                                            
      Inflammation, Chronic                            1 (13%)      1 (11%)                                                         
      Inflammation, Suppurative                        5 (63%)      3 (33%)                                                         
   Prostate                                           (45)         (11)         (44)                                                
      Inflammation, Suppurative                        2 (4%)                                                                       
   Seminal Vesicle                                    (47)         (10)         (44)                                                
      Dilatation                                       1 (2%)       1 (10%)                                                         
      Hemorrhage, Diffuse                              1 (2%)                                                                       
      Inflammation, Suppurative                        2 (4%)                                                                       
   Testes                                             (49)         (11)         (49)                                                
      Mineralization                                   2 (4%)                                                                       
      Bilateral, Atrophy                               2 (4%)                                                                       
      Interstitial Cell, Hyperplasia                   2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (43)         (15)         (45)                                                
      Mesenteric, Hemorrhage, Acute                                 1 (7%)                                                          
      Mesenteric, Hyperplasia                          1 (2%)                                                                       
   Lymph Node, Bronchial                              (29)         (7)          (29)                                                
      Edema                                            1 (3%)                                                                       
      Hyperplasia, Lymphoid                            1 (3%)                    1 (3%)                                             
   Lymph Node, Mandibular                             (34)         (9)          (33)                                                
      Hyperplasia, Lymphoid                            1 (3%)       1 (11%)      1 (3%)                                             
      Infiltration Cellular, Histiocyte                7 (21%)                   1 (3%)                                             
   Spleen                                             (49)         (16)         (49)                                                
      Atrophy                                                       1 (6%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                 3 (6%)       2 (13%)      2 (4%)                                             
      Hyperplasia, Lymphoid                                                      3 (6%)                                             
      Capsule, Fibrosis                                1 (2%)                                                                       
   Thymus                                             (30)         (4)          (31)                                                
      Cyst                                             3 (10%)                                                                      
      Mediastinum, Inflammation, Chronic                                         1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (17)         (50)                                                
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Dermis, Abscess                                  1 (2%)                                                                       
      Epidermis, Necrosis, Acute                       1 (2%)                                                                       
      Hair Follicle, Atrophy                           3 (6%)       5 (29%)                                                         
      Prepuce, Inflammation, Suppurative               3 (6%)                                                                       
      Prepuce, Ulcer                                                3 (18%)                                                         
      Sebaceous Gland, Hyperplasia                                  1 (6%)                                                          
      Subcutaneous Tissue, Edema                                    1 (6%)                                                          
      Subcutaneous Tissue, Hemorrhage, Acute           1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Acute                      1 (6%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic       1 (2%)       1 (6%)                                                          
      Subcutaneous Tissue, Inflammation,                                                                                            
          Suppurative                                  3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (11)         (50)                                                
      Cerebrum, Mineralization                                                   1 (2%)                                             
      Hypothalamus, Atrophy                                                      1 (2%)                                             
      Thalamus, Atrophy                                1 (2%)                                                                       
      Thalamus, Hemorrhage, Acute, Focal               1 (2%)                                                                       
      Thalamus, Mineralization                        29 (58%)      3 (27%)      8 (16%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (19)         (50)                                                
      Congestion, Diffuse                              1 (2%)                                                                       
      Granuloma                                                                  1 (2%)                                             
      Infiltration Cellular, Histiocyte                2 (4%)       1 (5%)       2 (4%)                                             
      Inflammation, Chronic, Multifocal               17 (34%)      3 (16%)     21 (42%)                                            
      Inflammation, Suppurative                                                  1 (2%)                                             
      Alveolus, Adenomatosis, Focal                    2 (4%)       1 (5%)                                                          
      Alveolus, Hyperplasia, Focal                     2 (4%)                                                                       
      Glands, Ectasia                                  8 (16%)                                                                      
      Glands, Inflammation, Suppurative                1 (2%)                                                                       
      Interstitium, Inflammation, Acute                3 (6%)                                                                       
   Nose                                               (50)         (50)         (50)                                                
      Glands, Dilatation                               1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Glands, Hyperplasia                              8 (16%)     47 (94%)     48 (96%)                                            
      Mucosa, Inflammation, Suppurative                2 (4%)      48 (96%)     47 (94%)                                            
      Olfactory Epithelium, Metaplasia                 4 (8%)      49 (98%)     50 (100%)                                           
      Respiratory Epithelium, Dysplasia                             1 (2%)       3 (6%)                                             
      Respiratory Epithelium, Dysplasia, Focal                                   1 (2%)                                             
      Respiratory Epithelium, Hyperplasia                          25 (50%)     40 (80%)                                            
      Respiratory Epithelium, Hyperplasia, Basal                                                                                    
          Cell                                                      1 (2%)       7 (14%)                                            
      Respiratory Epithelium, Metaplasia, Squamous                  4 (8%)       8 (16%)                                            
      Respiratory Epithelium, Regeneration                         46 (92%)     46 (92%)                                            
      Submucosa, Angiectasis                           1 (2%)       2 (4%)       5 (10%)                                            
   Trachea                                            (50)         (10)         (48)                                                
      Epithelium, Metaplasia, Squamous                                           1 (2%)                                             
      Glands, Dilatation                              41 (82%)                  27 (56%)                                            
      Mediastinum, Hyperplasia, Lymphoid               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (15)         (49)                                                
      Inflammation, Chronic                           39 (80%)      4 (27%)     30 (61%)                                            
      Inflammation, Suppurative                        4 (8%)       1 (7%)                                                          
      Capsule, Fibrosis                                             1 (7%)                                                          
      Cortex, Cyst                                                  2 (13%)                                                         
      Cortex, Metaplasia, Osseous                      1 (2%)                                                                       
      Medulla, Cyst                                                 1 (7%)                                                          
      Renal Tubule, Dilatation, Diffuse                1 (2%)                                                                       
      Renal Tubule, Regeneration                      32 (65%)      3 (20%)     32 (65%)                                            
      Renal Tubule, Regeneration, Multifocal                                     2 (4%)                                             
   Urinary Bladder                                    (49)         (11)         (49)                                                
      Calculus Micro Observation Only                               1 (9%)                                                          
      Inflammation, Chronic                            2 (4%)                                                                       
      Inflammation, Chronic, Multifocal                                          2 (4%)                                             
      Inflammation, Suppurative                        4 (8%)       1 (9%)                                                          
      Transitional Epithelium, Hyperplasia                          1 (9%)                                                          
      Transitional Epithelium, Necrosis                1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 75352-75352/75352


--multipart-boundary--