National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2515

TDMS Study 05080-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                        ALLYL GLYCIDYL ETHER


NTP Experiment-Test: 05080-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:18




       Facility:  Battelle Northwest

       Chemical CAS #:  106-92-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05080-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                              10            3            6                                                  
    Moribund                                           7            5            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           41           41                                                  
    Dead                                                            1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (47)         (9)          (48)                                                
   Gallbladder                                        (45)         (6)          (42)                                                
   Intestine Large, Colon                             (49)         (9)          (49)                                                
   Intestine Large, Rectum                            (50)         (8)          (49)                                                
   Intestine Small, Duodenum                          (46)         (7)          (46)                                                
   Intestine Small, Ileum                             (47)         (7)          (47)                                                
   Liver                                              (50)         (15)         (50)                                                
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hepatocellular Carcinoma                         4 (8%)       3 (20%)                                                         
      Hepatocellular Carcinoma, Multiple               1 (2%)                                                                       
      Hepatocellular Adenoma                           1 (2%)       2 (13%)      1 (2%)                                             
      Hepatocellular Adenoma, Multiple                                           1 (2%)                                             
      Histiocytic Sarcoma                              2 (4%)                                                                       
      Histiocytic Sarcoma, Metastatic, Uterus          1 (2%)                                                                       
   Mesentery                                          (13)         (4)          (8)                                                 
   Pancreas                                           (49)         (10)         (50)                                                
      Histiocytic Sarcoma                              2 (4%)                                                                       
   Salivary Glands                                    (50)         (9)          (50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (12)         (49)                                                
      Squamous Cell Papilloma                          1 (2%)       1 (8%)       1 (2%)                                             
   Stomach, Glandular                                 (49)         (10)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (9)          (50)                                                
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05080-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (47)         (9)          (48)                                                
      Subcapsular, Adenoma                                                       1 (2%)                                             
   Adrenal Gland, Cortex                              (47)         (8)          (48)                                                
      Histiocytic Sarcoma, Metastatic, Uterus          1 (2%)                                                                       
   Adrenal Gland, Medulla                             (47)         (7)          (47)                                                
      Pheochromocytoma Malignant                                    1 (14%)                                                         
   Islets, Pancreatic                                 (49)         (8)          (48)                                                
   Pituitary Gland                                    (44)         (17)         (45)                                                
      Pars Distalis, Adenoma                          12 (27%)      8 (47%)      2 (4%)                                             
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Intermedia, Adenoma                         1 (2%)                    2 (4%)                                             
   Thyroid Gland                                      (50)         (10)         (50)                                                
      Bilateral, Follicular Cell, Carcinoma                         1 (10%)                                                         
      Follicular Cell, Adenoma                         2 (4%)                    3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (5)                       (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (1)                                                                           
      Hemangiosarcoma                                  1 (100%)                                                                     
   Ovary                                              (49)         (19)         (50)                                                
      Cystadenocarcinoma                                                         1 (2%)                                             
      Granulosa Cell Tumor NOS                         1 (2%)                    1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Histiocytic Sarcoma, Metastatic, Uterus          1 (2%)                                                                       
      Luteoma                                          1 (2%)                                                                       
   Uterus                                             (50)         (24)         (50)                                                
      Histiocytic Sarcoma                              2 (4%)                                                                       
      Polyp Stromal                                                 1 (4%)       1 (2%)                                             
      Sarcoma Stromal                                  1 (2%)                                                                       
      Cervix, Leiomyoma                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (35)         (48)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node                                         (48)         (11)         (48)                                                
      Mediastinal, Histiocytic Sarcoma                 1 (2%)                                                                       
      Renal, Histiocytic Sarcoma                       1 (2%)                                                                       
   Lymph Node, Bronchial                              (38)         (7)          (37)                                                
                                                             Page   3                                                               
NTP Experiment-Test: 05080-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Adenocarcinoma, Metastatic, Mammary Gland        1 (3%)                                                                       
      Histiocytic Sarcoma                              2 (5%)                                                                       
   Lymph Node, Mandibular                             (42)         (6)          (40)                                                
      Adenocarcinoma, Metastatic, Mammary Gland        1 (2%)       1 (17%)                                                         
      Histiocytic Sarcoma                              2 (5%)                                                                       
   Spleen                                             (50)         (18)         (50)                                                
      Histiocytic Sarcoma                              2 (4%)                                                                       
   Thymus                                             (34)         (8)          (42)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (35)         (8)          (30)                                                
      Adenocarcinoma                                   4 (11%)      1 (13%)      1 (3%)                                             
      Carcinoma                                                                  1 (3%)                                             
   Skin                                               (50)         (18)         (50)                                                
      Fibrosarcoma                                                               1 (2%)                                             
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (9)          (50)                                                
      Sarcoma, Metastatic, Brain                                    1 (11%)                                                         
   Skeletal Muscle                                    (1)          (1)          (2)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (9)          (50)                                                
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
      Meninges, Meningioma NOS                                                   1 (2%)                                             
      Meninges, Sarcoma                                1 (2%)       1 (11%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (9)          (50)                                                
   Lung                                               (50)         (9)          (50)                                                
      Adenocarcinoma, Multiple, Metastatic,                                                                                         
          Mammary Gland                                             1 (11%)                                                         
      Adenocarcinoma, Metastatic, Mammary Gland        1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                                  1 (11%)      3 (6%)                                             
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Fibrosarcoma, Multiple, Metastatic, Skin                                   1 (2%)                                             
      Hepatocellular Carcinoma, Multiple,                                                                                           
                                                             Page   4                                                               
NTP Experiment-Test: 05080-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
          Metastatic, Liver                            1 (2%)       1 (11%)                                                         
      Histiocytic Sarcoma                              2 (4%)                                                                       
      Histiocytic Sarcoma, Metastatic, Uterus          1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Ear                                   1 (2%)                                             
   Nose                                               (49)         (49)         (50)                                                
      Hemangioma                                                                 1 (2%)                                             
      Respiratory Epithelium, Adenoma                                            1 (2%)                                             
   Trachea                                            (50)         (9)          (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                       (2)                                                 
      Squamous Cell Carcinoma                                                    1 (50%)                                            
   Harderian Gland                                                              (5)                                                 
      Adenoma                                                                    5 (100%)                                           
   Lacrimal Gland                                                               (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)         (49)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Histiocytic Sarcoma, Metastatic, Uterus          1 (2%)                                                                       
   Urinary Bladder                                    (47)         (9)          (47)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              3 (6%)                                                                       
      Lymphoma Malignant                               2 (4%)       1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                   9 (18%)      1 (2%)       4 (8%)                                             
      Lymphoma Malignant Mixed                        10 (20%)      4 (8%)      11 (22%)                                            
      Lymphoma Malignant Undifferentiated Cell         2 (4%)       3 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05080-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          21          31                                                   
     Total Primary Neoplasms                           59          29          48                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 14          12          15                                                   
     Total Benign Neoplasms                            18          13          23                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              30          15          21                                                   
     Total Malignant Neoplasms                         40          16          23                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           2           2                                                   
     Total Metastatic Neoplasm                         10           4           4                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                       2                                                   
     Total Uncertain Neoplasms                          1                       2                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05080-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               7            2            1                                                  
    Moribund                                           5            9            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           39           46                                                  
    Moribund                                           1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (41)         (4)          (46)                                                
   Intestine Small, Duodenum                          (43)         (10)         (49)                                                
   Intestine Small, Ileum                             (45)         (11)         (49)                                                
   Intestine Small, Jejunum                           (44)         (13)         (48)                                                
   Liver                                              (49)         (19)         (49)                                                
      Carcinosarcoma, Metastatic, Uncertain                                                                                         
          Primary Site                                 1 (2%)                                                                       
      Hemangiosarcoma, Multiple                                                  1 (2%)                                             
      Hepatocellular Carcinoma                        10 (20%)      4 (21%)      1 (2%)                                             
      Hepatocellular Adenoma                          12 (24%)      7 (37%)      5 (10%)                                            
      Hepatocellular Adenoma, Multiple                 3 (6%)                                                                       
   Mesentery                                          (2)                       (1)                                                 
   Pancreas                                           (49)         (12)         (49)                                                
   Salivary Glands                                    (49)         (10)         (49)                                                
   Stomach, Forestomach                               (50)         (15)         (49)                                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (15)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (11)         (50)                                                
   Heart                                              (50)         (11)         (50)                                                
      Hemangiosarcoma, Metastatic, Liver                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (11)         (50)                                                
      Capsule, Carcinosarcoma, Metastatic,                                                                                          
          Uncertain Primary Site                       1 (2%)                                                                       
   Adrenal Gland, Cortex                              (49)         (11)         (49)                                                
                                                             Page   7                                                               
NTP Experiment-Test: 05080-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Adrenal Gland, Medulla                             (48)         (10)         (48)                                                
      Pheochromocytoma NOS                             1 (2%)                                                                       
   Islets, Pancreatic                                 (46)         (10)         (46)                                                
   Pituitary Gland                                    (44)         (9)          (49)                                                
      Pars Intermedia, Adenoma                         1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (50)         (10)         (49)                                                
      Follicular Cell, Adenoma                         1 (2%)                    3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Carcinosarcoma, Metastatic, Uncertain                                                                                         
          Primary Site                                 1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (48)         (10)         (49)                                                
   Prostate                                           (45)         (11)         (44)                                                
   Seminal Vesicle                                    (47)         (10)         (44)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (49)         (11)         (50)                                                
   Lymph Node                                         (43)         (15)         (45)                                                
      Mediastinal, Mesenteric, Carcinosarcoma,                                                                                      
           Metastatic, Uncertain Primary Site          1 (2%)                                                                       
   Lymph Node, Bronchial                              (29)         (7)          (29)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (14%)                                                         
   Lymph Node, Mandibular                             (34)         (9)          (33)                                                
   Spleen                                             (49)         (16)         (49)                                                
      Hemangioma                                                    1 (6%)                                                          
      Capsule, Carcinosarcoma, Metastatic,                                                                                          
          Uncertain Primary Site                       1 (2%)                                                                       
   Thymus                                             (30)         (4)          (31)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (17)         (50)                                                
      Fibroma                                          1 (2%)                                                                       
      Sebaceous Gland, Adenoma                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05080-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (11)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (19)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     5 (10%)      2 (11%)      5 (10%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple           2 (4%)                    1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                5 (26%)      2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple                      2 (11%)      1 (2%)                                             
      Carcinosarcoma, Metastatic, Uncertain                                                                                         
          Primary Site                                 1 (2%)                                                                       
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Liver                            1 (2%)       1 (5%)                                                          
      Leiomyosarcoma                                                             1 (2%)                                             
   Nose                                               (50)         (50)         (50)                                                
      Respiratory Epithelium, Adenoma                                            3 (6%)                                             
      Submucosa, Hemangioma                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)                                                              
      Sarcoma                                          1 (100%)                                                                     
   Harderian Gland                                    (5)          (2)                                                              
      Adenoma                                          4 (80%)      2 (100%)                                                        
      Sarcoma, Metastatic, Eye                         1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (15)         (49)                                                
      Capsule, Carcinosarcoma, Metastatic,                                                                                          
          Uncertain Primary Site                       1 (2%)                                                                       
   Urinary Bladder                                    (49)         (11)         (49)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
                                                             Page   9                                                               
NTP Experiment-Test: 05080-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Lymphocytic                                             3 (6%)                                             
      Lymphoma Malignant Mixed                         2 (4%)       5 (10%)      1 (2%)                                             
      Lymphoma Malignant Undifferentiated Cell         1 (2%)       3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05080-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            32          26          21                                                   
     Total Primary Neoplasms                           46          31          30                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 25          10          18                                                   
     Total Benign Neoplasms                            30          12          20                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              13          18          10                                                   
     Total Malignant Neoplasms                         15          19          10                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           2           1                                                   
     Total Metastatic Neoplasm                          9           2           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.