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TDMS Study 05080-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                        ALLYL GLYCIDYL ETHER


NTP Experiment-Test: 05080-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:04




       Facility:  Battelle Northwest

       Chemical CAS #:  106-92-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05080-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:04  
____________________________________________________________________________________________________________________________________
         OSBORNE MENDEL RATS FEMALE                CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               9            8            5                                                  
    Moribund                                          17           12           20                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           30           25                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (47)         (50)         (49)                                                
      Acanthosis                                       1 (2%)                                                                       
      Hyperkeratosis                                   1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
   Intestine Large, Cecum                             (34)         (35)         (38)                                                
      Granuloma                                                                  1 (3%)                                             
      Hemorrhage                                                    1 (3%)                                                          
      Inflammation                                                               1 (3%)                                             
      Parasite Metazoan                                3 (9%)       2 (6%)       3 (8%)                                             
   Intestine Large, Colon                             (45)         (45)         (46)                                                
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
      Parasite Metazoan                                4 (9%)       2 (4%)       5 (11%)                                            
      Ulcer                                                         1 (2%)                                                          
   Intestine Large, Rectum                            (46)         (45)         (43)                                                
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Parasite Metazoan                                2 (4%)       3 (7%)                                                          
   Intestine Small, Jejunum                           (41)         (43)         (44)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Muscularis, Hyperplasia                          1 (2%)                                                                       
   Liver                                              (50)         (48)         (49)                                                
      Angiectasis                                      1 (2%)       3 (6%)       3 (6%)                                             
      Basophilic Focus                                              2 (4%)                                                          
      Basophilic Focus, Multiple                                    1 (2%)                                                          
      Clear Cell Focus                                 1 (2%)       1 (2%)       2 (4%)                                             
      Developmental Malformation                                    1 (2%)       1 (2%)                                             
      Eosinophilic Focus                               3 (6%)       1 (2%)                                                          
      Hematopoietic Cell Proliferation                 7 (14%)      4 (8%)       3 (6%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Leukocytosis                                     1 (2%)                    1 (2%)                                             
      Necrosis                                         2 (4%)       3 (6%)       3 (6%)                                             
      Vacuolization Cytoplasmic                        2 (4%)                                                                       
      Bile Duct, Cyst                                  1 (2%)                    1 (2%)                                             
      Bile Duct, Hyperplasia                           1 (2%)       3 (6%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05080-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:04  
____________________________________________________________________________________________________________________________________
         OSBORNE MENDEL RATS FEMALE                CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Cytomegaly                                        1 (2%)                                                          
   Mesentery                                                       (1)          (3)                                                 
      Artery, Inflammation                                          1 (100%)     1 (33%)                                            
   Pancreas                                           (50)         (48)         (49)                                                
      Atrophy                                          1 (2%)       3 (6%)       2 (4%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Acinus, Hyperplasia                                           2 (4%)                                                          
      Artery, Inflammation                                          1 (2%)       5 (10%)                                            
   Pharynx                                            (2)                                                                           
      Necrosis                                         1 (50%)                                                                      
      Ulcer                                            1 (50%)                                                                      
      Epithelium, Hyperplasia                          1 (50%)                                                                      
      Palate, Ulcer                                    1 (50%)                                                                      
   Salivary Glands                                    (48)         (47)         (48)                                                
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Karyomegaly                                      4 (8%)       1 (2%)       2 (4%)                                             
   Stomach, Forestomach                               (50)         (47)         (46)                                                
      Acanthosis                                       1 (2%)       3 (6%)       2 (4%)                                             
      Hyperkeratosis                                                             1 (2%)                                             
      Perforation                                                   1 (2%)                                                          
   Stomach, Glandular                                 (50)         (48)         (44)                                                
      Erosion                                                                    1 (2%)                                             
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mineralization                                   1 (2%)       2 (4%)       2 (5%)                                             
   Tooth                                              (1)          (1)                                                              
      Inflammation, Suppurative                                     1 (100%)                                                        
      Incisor, Developmental Malformation              1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)         (50)                                                
      Cardiomyopathy                                   7 (14%)      4 (8%)       5 (10%)                                            
      Embolus Bacterial                                1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)       1 (2%)       1 (2%)                                             
      Artery, Mineralization                                        1 (2%)       1 (2%)                                             
      Atrium, Thrombosis                               2 (4%)                                                                       
      Myocardium, Mineralization                                                 1 (2%)                                             
      Myocardium, Necrosis                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05080-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:04  
____________________________________________________________________________________________________________________________________
         OSBORNE MENDEL RATS FEMALE                CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (49)         (49)                                                
      Angiectasis                                     30 (60%)     36 (73%)     22 (45%)                                            
      Angiectasis, Multiple                            1 (2%)                                                                       
      Atrophy                                                                    1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hyperplasia                                     16 (32%)     11 (22%)     12 (24%)                                            
      Necrosis                                                      1 (2%)                                                          
      Vacuolization Cytoplasmic                       13 (26%)     11 (22%)      9 (18%)                                            
   Adrenal Gland, Medulla                             (49)         (48)         (47)                                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia                                      8 (16%)     10 (21%)      4 (9%)                                             
      Hyperplasia, Multiple                                         2 (4%)                                                          
   Parathyroid Gland                                  (26)         (32)         (33)                                                
      Hyperplasia                                      1 (4%)                                                                       
   Pituitary Gland                                    (50)         (45)         (48)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Pars Distalis, Cyst                              1 (2%)       2 (4%)                                                          
      Pars Distalis, Hyperplasia                       4 (8%)                    5 (10%)                                            
   Thyroid Gland                                      (49)         (47)         (47)                                                
      Ultimobranchial Cyst                             4 (8%)       9 (19%)      4 (9%)                                             
      C-Cell, Hyperplasia                             10 (20%)     12 (26%)     10 (21%)                                            
      Follicular Cell, Cyst                            1 (2%)       1 (2%)                                                          
      Follicular Cell, Hyperplasia                     2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (43)         (45)         (43)                                                
      Cyst                                             6 (14%)     12 (27%)     14 (33%)                                            
      Cyst, Multiple                                                1 (2%)                                                          
      Inflammation, Suppurative                       15 (35%)     13 (29%)     15 (35%)                                            
   Ovary                                              (49)         (48)         (49)                                                
      Cyst                                             4 (8%)      10 (21%)      8 (16%)                                            
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
      Capsule, Hyperplasia                                                       1 (2%)                                             
   Uterus                                             (50)         (50)         (50)                                                
      Inflammation, Suppurative                        7 (14%)      1 (2%)       3 (6%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Artery, Inflammation                                                       1 (2%)                                             
      Endometrium, Hyperplasia                        14 (28%)     22 (44%)     12 (24%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05080-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:04  
____________________________________________________________________________________________________________________________________
         OSBORNE MENDEL RATS FEMALE                CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Endometrium, Metaplasia, Squamous                2 (4%)       5 (10%)      6 (12%)                                            
      Lumen, Dilatation                                2 (4%)       4 (8%)       3 (6%)                                             
      Lumen, Hemorrhage                                             2 (4%)       1 (2%)                                             
      Wall, Necrosis                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (45)         (48)                                                
      Atrophy                                          4 (8%)                                                                       
   Lymph Node                                         (48)         (50)         (49)                                                
      Mesenteric, Hemorrhage                                        1 (2%)                                                          
      Renal, Hyperplasia, Lymphoid                                  1 (2%)                                                          
   Lymph Node, Bronchial                              (34)         (39)         (43)                                                
      Fibrosis                                                                   1 (2%)                                             
      Hemorrhage                                       1 (3%)       1 (3%)       1 (2%)                                             
   Lymph Node, Mandibular                             (43)         (45)         (44)                                                
      Hemorrhage                                                    2 (4%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
   Spleen                                             (50)         (48)         (49)                                                
      Cyst                                                                       1 (2%)                                             
      Hematopoietic Cell Proliferation                 6 (12%)      5 (10%)      8 (16%)                                            
      Artery, Inflammation                                                       1 (2%)                                             
   Thymus                                             (41)         (47)         (43)                                                
      Cyst                                                          4 (9%)                                                          
      Inflammation, Suppurative                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Galactocele                                      2 (4%)       1 (2%)       1 (2%)                                             
      Inflammation, Suppurative                        2 (4%)       1 (2%)                                                          
   Skin                                               (48)         (49)         (49)                                                
      Acanthosis                                                                 2 (4%)                                             
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Hyperkeratosis                                                             1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (49)         (50)                                                
      Fibrous Osteodystrophy                                        1 (2%)       1 (2%)                                             
      Osteopetrosis                                                              1 (2%)                                             
      Cranium, Necrosis                                1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05080-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:04  
____________________________________________________________________________________________________________________________________
         OSBORNE MENDEL RATS FEMALE                CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)                                                
      Compression                                      3 (6%)       5 (10%)      2 (4%)                                             
      Gliosis                                                                    1 (2%)                                             
      Hemorrhage                                       2 (4%)       2 (4%)                                                          
      Ventricle, Dilatation                                         1 (2%)                                                          
   Spinal Cord                                                                  (1)                                                 
      White Matter, Degeneration                                                 1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (48)         (48)                                                
      Foreign Body                                                  1 (2%)                                                          
      Inflammation, Suppurative                        3 (6%)       5 (10%)                                                         
      Epithelium, Hyperplasia                                       1 (2%)                                                          
   Lung                                               (49)         (50)         (49)                                                
      Foreign Body                                     1 (2%)       1 (2%)       1 (2%)                                             
      Hemorrhage                                       2 (4%)                                                                       
      Inflammation, Granulomatous                      3 (6%)       7 (14%)      3 (6%)                                             
      Leukocytosis                                     1 (2%)                                                                       
      Thrombosis                                       2 (4%)                                                                       
      Alveolar Epithelium, Hyperplasia                 4 (8%)      14 (28%)     14 (29%)                                            
      Alveolus, Fibrosis                               1 (2%)       2 (4%)       2 (4%)                                             
      Alveolus, Infiltration Cellular, Histiocyte     21 (43%)     41 (82%)     31 (63%)                                            
      Alveolus, Inflammation, Suppurative             13 (27%)      5 (10%)      4 (8%)                                             
      Artery, Inflammation                                                       1 (2%)                                             
      Artery, Mineralization                          20 (41%)     16 (32%)     15 (31%)                                            
      Bronchiole, Hyperplasia                                                    1 (2%)                                             
      Pleura, Inflammation, Chronic                                              1 (2%)                                             
   Nose                                               (49)         (48)         (47)                                                
      Inflammation, Suppurative                        5 (10%)      7 (15%)     11 (23%)                                            
      Glands, Dilatation                               9 (18%)     29 (60%)     39 (83%)                                            
      Nasolacrimal Duct, Inflammation, Suppurative     4 (8%)       1 (2%)                                                          
      Olfactory Epithelium, Degeneration                           46 (96%)     47 (100%)                                           
      Olfactory Epithelium, Metaplasia                              4 (8%)       6 (13%)                                            
      Olfactory Epithelium, Metaplasia, Squamous                    9 (19%)     31 (66%)                                            
      Respiratory Epithelium, Dysplasia                                          1 (2%)                                             
      Respiratory Epithelium, Hyperplasia              1 (2%)      18 (38%)     22 (47%)                                            
      Respiratory Epithelium, Metaplasia, Squamous                 37 (77%)     38 (81%)                                            
   Trachea                                            (49)         (49)         (48)                                                
      Inflammation, Suppurative                        2 (4%)       1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Glands, Dilatation                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05080-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:04  
____________________________________________________________________________________________________________________________________
         OSBORNE MENDEL RATS FEMALE                CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (3)                                                              
      Cataract, Multiple                                            1 (33%)                                                         
   Lacrimal Gland                                     (5)          (1)          (2)                                                 
      Hyperplasia                                                   1 (100%)                                                        
      Inflammation, Chronic                            3 (60%)      1 (100%)     2 (100%)                                           
      Inflammation, Suppurative                        1 (20%)                                                                      
      Karyomegaly                                      4 (80%)      1 (100%)     2 (100%)                                           
      Necrosis                                         1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (48)         (49)                                                
      Cyst                                                          1 (2%)       3 (6%)                                             
      Nephropathy, Chronic                            48 (96%)     42 (88%)     46 (94%)                                            
      Pelvis, Dilatation                               1 (2%)                                                                       
      Pelvis, Hyperplasia                              3 (6%)       3 (6%)       2 (4%)                                             
      Pelvis, Mineralization                          15 (30%)     15 (31%)     15 (31%)                                            
      Renal Tubule, Degeneration                                    1 (2%)                                                          
      Renal Tubule, Mineralization                    14 (28%)     18 (38%)     11 (22%)                                            
   Urinary Bladder                                    (49)         (47)         (47)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05080-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:04  
____________________________________________________________________________________________________________________________________
         OSBORNE MENDEL RATS MALE                  CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                              27           27           29                                                  
    Moribund                                          11           12           13                                                  
  Survivors                                                                                                                         
    Moribund                                                        1                                                               
    Terminal Sacrifice                                12           10            8                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (23)         (21)         (15)                                                
      Parasite Metazoan                                2 (9%)       1 (5%)       2 (13%)                                            
      Artery, Inflammation                                                       1 (7%)                                             
   Intestine Large, Colon                             (39)         (38)         (34)                                                
      Parasite Metazoan                                4 (10%)      3 (8%)       4 (12%)                                            
   Intestine Large, Rectum                            (40)         (42)         (38)                                                
      Parasite Metazoan                                4 (10%)      2 (5%)                                                          
      Artery, Inflammation                                          2 (5%)                                                          
   Intestine Small, Ileum                             (24)         (27)         (23)                                                
      Artery, Inflammation                                                       1 (4%)                                             
   Liver                                              (49)         (49)         (47)                                                
      Angiectasis                                      1 (2%)       1 (2%)       2 (4%)                                             
      Basophilic Focus                                 1 (2%)       1 (2%)                                                          
      Clear Cell Focus                                 1 (2%)       4 (8%)       3 (6%)                                             
      Developmental Malformation                       1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)       2 (4%)       1 (2%)                                             
      Inflammation, Granulomatous                      3 (6%)                                                                       
      Inflammation, Suppurative                                     1 (2%)                                                          
      Necrosis                                                      3 (6%)       2 (4%)                                             
      Bile Duct, Cyst                                                            1 (2%)                                             
      Bile Duct, Fibrosis                              1 (2%)       2 (4%)       6 (13%)                                            
      Bile Duct, Hyperplasia                                        1 (2%)       2 (4%)                                             
   Mesentery                                          (1)                       (1)                                                 
      Inflammation                                     1 (100%)                                                                     
      Artery, Inflammation                                                       1 (100%)                                           
   Pancreas                                           (48)         (48)         (44)                                                
      Atrophy                                          2 (4%)       6 (13%)      2 (5%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Infarct                                                                    1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)                                                          
      Acinus, Hyperplasia                              1 (2%)       1 (2%)       2 (5%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05080-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:04  
____________________________________________________________________________________________________________________________________
         OSBORNE MENDEL RATS MALE                  CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Artery, Inflammation                             6 (13%)      7 (15%)      9 (20%)                                            
      Artery, Thrombosis                                                         1 (2%)                                             
   Salivary Glands                                    (50)         (46)         (47)                                                
      Cyst                                                          1 (2%)                                                          
      Inflammation, Chronic                           12 (24%)      6 (13%)      5 (11%)                                            
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Inflammation, Suppurative                        2 (4%)                                                                       
      Karyomegaly                                     21 (42%)     23 (50%)     20 (43%)                                            
   Stomach                                            (48)         (49)         (46)                                                
      Artery, Inflammation                             1 (2%)       1 (2%)                                                          
   Stomach, Forestomach                               (45)         (43)         (44)                                                
      Acanthosis                                                    2 (5%)                                                          
      Hyperkeratosis                                                             1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
   Stomach, Glandular                                 (48)         (48)         (46)                                                
      Cyst                                                                       1 (2%)                                             
      Developmental Malformation                                    1 (2%)                                                          
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Necrotizing                                                  1 (2%)                                             
      Mineralization                                   4 (8%)       1 (2%)       1 (2%)                                             
      Necrosis                                                      1 (2%)       1 (2%)                                             
      Artery, Inflammation                             2 (4%)                    1 (2%)                                             
   Tongue                                             (2)                                                                           
      Hyperplasia, Squamous                            1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy                                  12 (24%)     12 (24%)     19 (38%)                                            
      Inflammation, Suppurative                                                  2 (4%)                                             
      Aortic Valve, Mineralization                     2 (4%)                                                                       
      Artery, Inflammation                             2 (4%)       1 (2%)       1 (2%)                                             
      Artery, Mineralization                           7 (14%)      2 (4%)       2 (4%)                                             
      Atrium, Mineralization                           1 (2%)                                                                       
      Atrium, Thrombosis                               8 (16%)      3 (6%)       8 (16%)                                            
      Endocardium, Fibrosis                                         1 (2%)       1 (2%)                                             
      Myocardium, Hemorrhage                                                     1 (2%)                                             
      Ventricle, Mineralization                        1 (2%)                                                                       
      Ventricle, Thrombosis                                                      1 (2%)                                             
      Ventricle Right, Dilatation                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05080-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:04  
____________________________________________________________________________________________________________________________________
         OSBORNE MENDEL RATS MALE                  CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)         (48)         (48)                                                
      Angiectasis                                                   1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia                                      8 (17%)     15 (31%)     13 (27%)                                            
      Hypertrophy                                                                1 (2%)                                             
      Infarct                                                                    1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Necrosis                                                      1 (2%)       1 (2%)                                             
      Vacuolization Cytoplasmic                       10 (21%)     14 (29%)     17 (35%)                                            
   Adrenal Gland, Medulla                             (47)         (47)         (47)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                     10 (21%)     11 (23%)     10 (21%)                                            
      Hyperplasia, Multiple                            1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
   Islets, Pancreatic                                 (48)         (48)         (45)                                                
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
   Parathyroid Gland                                  (36)         (30)         (38)                                                
      Hyperplasia                                      2 (6%)       1 (3%)       1 (3%)                                             
      Hyperplasia, Multiple                                         1 (3%)                                                          
   Pituitary Gland                                    (47)         (46)         (44)                                                
      Pars Distalis, Cyst                              2 (4%)       3 (7%)       3 (7%)                                             
      Pars Distalis, Hyperplasia                       2 (4%)       2 (4%)       4 (9%)                                             
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
   Thyroid Gland                                      (43)         (46)         (46)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Ultimobranchial Cyst                             4 (9%)       2 (4%)       3 (7%)                                             
      C-Cell, Hyperplasia                             10 (23%)      7 (15%)      7 (15%)                                            
      Follicular Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (43)         (42)         (42)                                                
      Artery, Inflammation                             1 (2%)                                                                       
   Preputial Gland                                    (49)         (48)         (46)                                                
      Cyst                                             7 (14%)      2 (4%)       2 (4%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Suppurative                       22 (45%)     23 (48%)     15 (33%)                                            
   Prostate                                           (49)         (49)         (46)                                                
      Cyst                                                          1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05080-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:04  
____________________________________________________________________________________________________________________________________
         OSBORNE MENDEL RATS MALE                  CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Suppurative                        3 (6%)       4 (8%)       4 (9%)                                             
      Mineralization                                                             1 (2%)                                             
      Artery, Inflammation                                                       1 (2%)                                             
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Seminal Vesicle                                    (49)         (49)         (45)                                                
      Inflammation, Suppurative                        3 (6%)       2 (4%)       4 (9%)                                             
      Artery, Inflammation                             1 (2%)                    1 (2%)                                             
   Testes                                             (49)         (49)         (49)                                                
      Infarct                                                                    1 (2%)                                             
      Mineralization                                   1 (2%)       6 (12%)      7 (14%)                                            
      Artery, Inflammation                            10 (20%)     10 (20%)     11 (22%)                                            
      Seminiferous Tubule, Atrophy                     7 (14%)      6 (12%)      3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (46)         (48)         (44)                                                
      Fibrosis                                                                   1 (2%)                                             
   Lymph Node                                         (48)         (44)         (45)                                                
      Fibrosis                                                      1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Mediastinal, Hemorrhage                                       1 (2%)                                                          
      Renal, Hemorrhage                                3 (6%)                                                                       
   Lymph Node, Bronchial                              (40)         (29)         (38)                                                
      Hemorrhage                                       5 (13%)                   6 (16%)                                            
      Inflammation, Granulomatous                                   1 (3%)                                                          
   Lymph Node, Mandibular                             (44)         (40)         (42)                                                
      Hemorrhage                                       2 (5%)                    3 (7%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       1 (3%)       2 (5%)                                             
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                    2 (5%)                                             
   Spleen                                             (50)         (49)         (46)                                                
      Hematopoietic Cell Proliferation                              4 (8%)       1 (2%)                                             
      Hemorrhage                                                    2 (4%)                                                          
      Infarct                                                       1 (2%)       1 (2%)                                             
   Thymus                                             (46)         (46)         (44)                                                
      Hemorrhage                                                                 2 (5%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Artery, Inflammation                             1 (2%)                    2 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05080-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:04  
____________________________________________________________________________________________________________________________________
         OSBORNE MENDEL RATS MALE                  CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (49)         (49)                                                
      Giant Cell                                       1 (2%)                                                                       
      Granuloma                                        1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)                                                
      Osteoporosis                                                               1 (2%)                                             
   Skeletal Muscle                                    (1)          (1)                                                              
      Laryngeal, Degeneration                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Compression                                      1 (2%)       1 (2%)                                                          
      Demyelination                                    1 (2%)                                                                       
      Gliosis                                                       1 (2%)                                                          
      Hemorrhage                                       4 (8%)       2 (4%)       3 (6%)                                             
      Necrosis                                                                   1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Ventricle, Dilatation                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (39)         (45)         (43)                                                
      Inflammation, Chronic                            2 (5%)                    2 (5%)                                             
      Inflammation, Suppurative                                     1 (2%)       2 (5%)                                             
      Artery, Inflammation                                                       1 (2%)                                             
      Epithelium, Hyperplasia                                                    2 (5%)                                             
   Lung                                               (42)         (48)         (45)                                                
      Foreign Body                                     1 (2%)       1 (2%)                                                          
      Hemorrhage                                       7 (17%)      7 (15%)      8 (18%)                                            
      Inflammation, Granulomatous                      5 (12%)      3 (6%)       2 (4%)                                             
      Leukocytosis                                                  1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 2 (5%)       6 (13%)      5 (11%)                                            
      Alveolus, Edema                                  1 (2%)       2 (4%)       2 (4%)                                             
      Alveolus, Fibrosis                               2 (5%)       4 (8%)       2 (4%)                                             
      Alveolus, Infiltration Cellular, Histiocyte      7 (17%)     17 (35%)     19 (42%)                                            
      Alveolus, Inflammation, Suppurative              6 (14%)      5 (10%)      7 (16%)                                            
      Alveolus, Mineralization                                                   1 (2%)                                             
      Artery, Inflammation                             7 (17%)     12 (25%)      6 (13%)                                            
      Artery, Mineralization                          18 (43%)     22 (46%)     16 (36%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05080-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:04  
____________________________________________________________________________________________________________________________________
         OSBORNE MENDEL RATS MALE                  CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Bronchiole, Infiltration Cellular, Histiocyte                 1 (2%)                                                          
      Bronchiole, Inflammation, Suppurative            1 (2%)       1 (2%)       1 (2%)                                             
   Nose                                               (44)         (46)         (43)                                                
      Foreign Body                                     1 (2%)       3 (7%)       1 (2%)                                             
      Inflammation, Suppurative                        9 (20%)     27 (59%)     18 (42%)                                            
      Inflammation, Membranous                         3 (7%)       4 (9%)       7 (16%)                                            
      Glands, Dilatation                               8 (18%)     20 (43%)     21 (49%)                                            
      Nasolacrimal Duct, Inflammation, Suppurative     7 (16%)      3 (7%)       9 (21%)                                            
      Olfactory Epithelium, Degeneration                           45 (98%)     43 (100%)                                           
      Olfactory Epithelium, Metaplasia                              6 (13%)      9 (21%)                                            
      Olfactory Epithelium, Metaplasia, Squamous                   19 (41%)     35 (81%)                                            
      Respiratory Epithelium, Hyperplasia              4 (9%)      33 (72%)     30 (70%)                                            
      Respiratory Epithelium, Metaplasia, Squamous     4 (9%)      40 (87%)     38 (88%)                                            
   Trachea                                            (40)         (45)         (42)                                                
      Inflammation, Chronic                                                      2 (5%)                                             
      Inflammation, Suppurative                        1 (3%)                                                                       
      Artery, Inflammation                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)          (2)                                                 
      Cataract                                                                   1 (50%)                                            
   Harderian Gland                                    (3)          (2)          (8)                                                 
      Hyperplasia                                      2 (67%)                                                                      
      Inflammation, Chronic                            1 (33%)                   8 (100%)                                           
      Karyomegaly                                                                7 (88%)                                            
   Lacrimal Gland                                     (19)         (21)         (7)                                                 
      Hyperplasia                                                                1 (14%)                                            
      Inflammation, Chronic                           19 (100%)    21 (100%)     7 (100%)                                           
      Inflammation, Suppurative                                     1 (5%)                                                          
      Karyomegaly                                     19 (100%)    21 (100%)     7 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (48)                                                
      Cyst                                             1 (2%)       1 (2%)       2 (4%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
      Nephropathy, Chronic                            49 (98%)     49 (100%)    47 (98%)                                            
      Artery, Mineralization                           1 (2%)                                                                       
      Glomerulus, Mineralization                                                 1 (2%)                                             
      Pelvis, Hemorrhage                                            1 (2%)                                                          
      Pelvis, Hyperplasia                              2 (4%)       2 (4%)       2 (4%)                                             
      Pelvis, Inflammation, Suppurative                             2 (4%)       3 (6%)                                             
      Pelvis, Mineralization                           3 (6%)       3 (6%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05080-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:04  
____________________________________________________________________________________________________________________________________
         OSBORNE MENDEL RATS MALE                  CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Mineralization                     2 (4%)                    1 (2%)                                             
   Urinary Bladder                                    (46)         (49)         (44)                                                
      Calculus Gross Observation                       2 (4%)                                                                       
      Calculus Micro Observation Only                  3 (7%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                      2 (4%)       1 (2%)       3 (7%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)       2 (4%)       4 (9%)                                             
      Artery, Inflammation                                          1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
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                             ----------              END OF REPORT             ----------                                           
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