TDMS Study 05080-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
ALLYL GLYCIDYL ETHER
NTP Experiment-Test: 05080-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06
Facility: Battelle Northwest
Chemical CAS #: 106-92-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS FEMALE CONTROL 5 PPM 10 PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 9 8 5
Moribund 17 12 20
Survivors
Terminal Sacrifice 24 30 25
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Ileum (40) (43) (45)
Liver (50) (48) (49)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Adenoma 2 (4%) 3 (6%) 1 (2%)
Neoplastic Nodule 1 (2%)
Mesentery (1) (3)
Adenocarcinoma, Metastatic, Uterus 2 (67%)
Pancreas (50) (48) (49)
Adenocarcinoma, Metastatic, Uterus 2 (4%)
Salivary Glands (48) (47) (48)
Stomach, Forestomach (50) (47) (46)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Glandular, Adenocarcinoma, Metastatic, Uterus 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49) (50)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (49) (49)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Adenoma 3 (6%) 5 (10%) 2 (4%)
Adenoma, Multiple 1 (2%)
Adrenal Gland, Medulla (49) (48) (47)
Pheochromocytoma Benign 6 (12%) 2 (4%) 3 (6%)
Pheochromocytoma Benign, Multiple 3 (6%)
Islets, Pancreatic (50) (48) (48)
Adenoma 4 (8%)
Page 2
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS FEMALE CONTROL 5 PPM 10 PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Carcinoma 1 (2%)
Pituitary Gland (50) (45) (48)
Pars Distalis, Adenoma 26 (52%) 26 (58%) 20 (42%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Thyroid Gland (49) (47) (47)
C-Cell, Adenoma 10 (20%) 14 (30%) 10 (21%)
C-Cell, Adenoma, Multiple 1 (2%) 5 (11%) 2 (4%)
C-Cell, Carcinoma 4 (8%) 2 (4%) 4 (9%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (43) (45) (43)
Ovary (49) (48) (49)
Adenocarcinoma, Metastatic, Uterus 2 (4%)
Embryonal Carcinoma 1 (2%)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Granulosa-Theca Tumor Benign 1 (2%)
Hamartoma 1 (2%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Squamous Cell Carcinoma, Metastatic, Uterus 1 (2%)
Uterus (50) (50) (50)
Adenocarcinoma 2 (4%) 3 (6%)
Polyp Stromal 10 (20%) 11 (22%) 9 (18%)
Sarcoma 1 (2%)
Sarcoma Stromal 1 (2%) 2 (4%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Endometrium, Adenoma, Papillary 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (45) (48)
Lymph Node (48) (50) (49)
Lymph Node, Bronchial (34) (39) (43)
Adenocarcinoma, Metastatic, Uterus 2 (5%)
Basosquamous Tumor Malignant, Metastatic,
Thymus 1 (3%)
Lymph Node, Mandibular (43) (45) (44)
Spleen (50) (48) (49)
Adenocarcinoma, Metastatic, Uterus 2 (4%)
Page 3
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS FEMALE CONTROL 5 PPM 10 PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Thymus (41) (47) (43)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Basosquamous Tumor Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50)
Adenocarcinoma 2 (4%) 5 (10%) 4 (8%)
Adenocarcinoma, Multiple 1 (2%)
Fibroadenoma 23 (46%) 17 (34%) 20 (40%)
Fibroadenoma, Multiple 2 (4%) 2 (4%)
Fibrosarcoma 1 (2%)
Skin (48) (49) (49)
Fibroma 1 (2%)
Sarcoma 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2)
Diaphragm, Adenocarcinoma, Metastatic, Uterus 2 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Granular Cell Tumor Benign 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (50) (49)
Adenocarcinoma, Metastatic, Mammary Gland 1 (2%)
Adenocarcinoma, Metastatic, Uterus 2 (4%)
Basosquamous Tumor Malignant, Metastatic,
Thymus 1 (2%)
Carcinoma Adenosquamous 1 (2%)
Sarcoma, Metastatic, Uterus 1 (2%)
Nose (49) (48) (47)
Respiratory Epithelium, Adenoma, Papillary 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS FEMALE CONTROL 5 PPM 10 PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (48) (49)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Liposarcoma 1 (2%)
Nephroblastoma 1 (2%)
Urinary Bladder (49) (47) (47)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant 1 (2%) 1 (2%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Undifferentiated Cell 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS FEMALE CONTROL 5 PPM 10 PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 43 47 44
Total Primary Neoplasms 103 107 94
Total Animals with Benign Neoplasms 40 44 37
Total Benign Neoplasms 91 88 74
Total Animals with Malignant Neoplasms 12 19 17
Total Malignant Neoplasms 12 19 20
Total Animals with Metastatic Neoplasms 2 3 3
Total Metastatic Neoplasm 3 3 22
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS MALE CONTROL 5 PPM 10 PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 27 27 29
Moribund 11 12 13
Survivors
Moribund 1
Terminal Sacrifice 12 10 8
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (23) (21) (15)
Intestine Large, Colon (39) (38) (34)
Intestine Large, Rectum (40) (42) (38)
Intestine Small, Duodenum (33) (37) (33)
Intestine Small, Ileum (24) (27) (23)
Intestine Small, Jejunum (24) (27) (25)
Adenocarcinoma, Mucinous 1 (4%)
Liver (49) (49) (47)
Adenoma 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Pancreas (48) (48) (44)
Salivary Glands (50) (46) (47)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Stomach, Forestomach (45) (43) (44)
Squamous Cell Carcinoma 1 (2%) 2 (5%) 1 (2%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (48) (48) (46)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (48) (48) (48)
Adenoma 1 (2%) 1 (2%) 2 (4%)
Carcinoma 1 (2%)
Adrenal Gland, Medulla (47) (47) (47)
Pheochromocytoma Malignant 5 (11%) 3 (6%)
Pheochromocytoma Malignant, Multiple 2 (4%) 1 (2%)
Page 7
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS MALE CONTROL 5 PPM 10 PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pheochromocytoma Benign 9 (19%) 7 (15%) 12 (26%)
Pheochromocytoma Benign, Multiple 1 (2%) 7 (15%) 2 (4%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (48) (48) (45)
Adenoma 2 (4%) 1 (2%)
Parathyroid Gland (36) (30) (38)
Adenoma 1 (3%) 2 (5%)
Pituitary Gland (47) (46) (44)
Pars Distalis, Adenoma 11 (23%) 12 (26%) 13 (30%)
Pars Distalis, Carcinoma 2 (4%)
Pars Intermedia, Adenoma 2 (4%) 2 (5%)
Thyroid Gland (43) (46) (46)
C-Cell, Adenoma 8 (19%) 9 (20%) 10 (22%)
C-Cell, Adenoma, Multiple 1 (2%) 2 (4%)
C-Cell, Carcinoma 5 (12%) 1 (2%) 3 (7%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (49) (48) (46)
Prostate (49) (49) (46)
Sarcoma, Metastatic, Seminal Vesicle 1 (2%)
Seminal Vesicle (49) (49) (45)
Sarcoma 1 (2%)
Testes (49) (49) (49)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (46) (48) (44)
Lymph Node (48) (44) (45)
Lymph Node, Bronchial (40) (29) (38)
Carcinoma, Metastatic, Thyroid Gland 1 (3%)
Lymph Node, Mandibular (44) (40) (42)
Carcinoma, Metastatic, Harderian Gland 1 (3%)
Spleen (50) (49) (46)
Thymus (46) (46) (44)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS MALE CONTROL 5 PPM 10 PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (27) (40) (32)
Fibroadenoma 2 (6%)
Skin (49) (49) (49)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Fibroma 2 (4%) 1 (2%)
Hemangioma 1 (2%)
Keratoacanthoma 1 (2%)
Sarcoma 2 (4%)
Lip, Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49)
Cranium, Schwannoma Malignant, Metastatic,
Brain 1 (2%)
Cranium, Squamous Cell Carcinoma, Metastatic,
Nose 1 (2%)
Skeletal Muscle (1) (1)
Sarcoma, Metastatic, Skin 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Oligodendroglioma Malignant 1 (2%)
Schwannoma Malignant 1 (2%)
Meninges, Granular Cell Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (39) (45) (43)
Carcinoma, Metastatic, Thyroid Gland 1 (3%)
Lung (42) (48) (45)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Pheochromocytoma Malignant, Metastatic 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Schwannoma Malignant, Metastatic, Brain 1 (2%)
Nose (44) (46) (43)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Olfactory Epithelium, Adenocarcinoma, Poorly
Differentiated 1 (2%)
Respiratory Epithelium, Adenoma, Papillary 1 (2%)
Respiratory Epithelium, Squamous Cell
Page 9
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS MALE CONTROL 5 PPM 10 PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Carcinoma 1 (2%)
Trachea (40) (45) (42)
Carcinoma, Metastatic, Thyroid Gland 1 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (2)
Harderian Gland (3) (2) (8)
Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (48)
Adenoma 1 (2%)
Adenoma, Multiple 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Urinary Bladder (46) (49) (44)
Sarcoma, Metastatic, Seminal Vesicle 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant 1 (2%) 1 (2%) 1 (2%)
Lymphoma Malignant Histiocytic 1 (2%) 1 (2%) 1 (2%)
Lymphoma Malignant Undifferentiated Cell 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS MALE CONTROL 5 PPM 10 PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 30 37 38
Total Primary Neoplasms 59 57 67
Total Animals with Benign Neoplasms 25 31 32
Total Benign Neoplasms 38 45 51
Total Animals with Malignant Neoplasms 18 12 14
Total Malignant Neoplasms 21 12 16
Total Animals with Metastatic Neoplasms 2 4 2
Total Metastatic Neoplasm 7 10 2
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 65918-65918/65918
--multipart-boundary--