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TDMS Study 05080-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                        ALLYL GLYCIDYL ETHER


NTP Experiment-Test: 05080-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:06




       Facility:  Battelle Northwest

       Chemical CAS #:  106-92-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05080-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         OSBORNE MENDEL RATS FEMALE                CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               9            8            5                                                  
    Moribund                                          17           12           20                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           30           25                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Ileum                             (40)         (43)         (45)                                                
   Liver                                              (50)         (48)         (49)                                                
      Adenocarcinoma, Metastatic, Uterus                                         1 (2%)                                             
      Adenoma                                          2 (4%)       3 (6%)       1 (2%)                                             
      Neoplastic Nodule                                1 (2%)                                                                       
   Mesentery                                                       (1)          (3)                                                 
      Adenocarcinoma, Metastatic, Uterus                                         2 (67%)                                            
   Pancreas                                           (50)         (48)         (49)                                                
      Adenocarcinoma, Metastatic, Uterus                                         2 (4%)                                             
   Salivary Glands                                    (48)         (47)         (48)                                                
   Stomach, Forestomach                               (50)         (47)         (46)                                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Glandular, Adenocarcinoma, Metastatic, Uterus                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)         (50)                                                
      Adenocarcinoma, Metastatic, Uterus                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (49)         (49)                                                
      Adenocarcinoma, Metastatic, Uterus                                         1 (2%)                                             
      Adenoma                                          3 (6%)       5 (10%)      2 (4%)                                             
      Adenoma, Multiple                                             1 (2%)                                                          
   Adrenal Gland, Medulla                             (49)         (48)         (47)                                                
      Pheochromocytoma Benign                          6 (12%)      2 (4%)       3 (6%)                                             
      Pheochromocytoma Benign, Multiple                                          3 (6%)                                             
   Islets, Pancreatic                                 (50)         (48)         (48)                                                
      Adenoma                                          4 (8%)                                                                       
                                                             Page   2                                                               
NTP Experiment-Test: 05080-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         OSBORNE MENDEL RATS FEMALE                CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (50)         (45)         (48)                                                
      Pars Distalis, Adenoma                          26 (52%)     26 (58%)     20 (42%)                                            
      Pars Distalis, Carcinoma                         1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (49)         (47)         (47)                                                
      C-Cell, Adenoma                                 10 (20%)     14 (30%)     10 (21%)                                            
      C-Cell, Adenoma, Multiple                        1 (2%)       5 (11%)      2 (4%)                                             
      C-Cell, Carcinoma                                4 (8%)       2 (4%)       4 (9%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (43)         (45)         (43)                                                
   Ovary                                              (49)         (48)         (49)                                                
      Adenocarcinoma, Metastatic, Uterus                                         2 (4%)                                             
      Embryonal Carcinoma                                                        1 (2%)                                             
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Granulosa-Theca Tumor Benign                     1 (2%)                                                                       
      Hamartoma                                        1 (2%)                                                                       
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Uterus                                1 (2%)                                             
   Uterus                                             (50)         (50)         (50)                                                
      Adenocarcinoma                                   2 (4%)                    3 (6%)                                             
      Polyp Stromal                                   10 (20%)     11 (22%)      9 (18%)                                            
      Sarcoma                                                       1 (2%)                                                          
      Sarcoma Stromal                                  1 (2%)       2 (4%)       1 (2%)                                             
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Endometrium, Adenoma, Papillary                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (45)         (48)                                                
   Lymph Node                                         (48)         (50)         (49)                                                
   Lymph Node, Bronchial                              (34)         (39)         (43)                                                
      Adenocarcinoma, Metastatic, Uterus                                         2 (5%)                                             
      Basosquamous Tumor Malignant, Metastatic,                                                                                     
           Thymus                                      1 (3%)                                                                       
   Lymph Node, Mandibular                             (43)         (45)         (44)                                                
   Spleen                                             (50)         (48)         (49)                                                
      Adenocarcinoma, Metastatic, Uterus                                         2 (4%)                                             
                                                             Page   3                                                               
NTP Experiment-Test: 05080-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         OSBORNE MENDEL RATS FEMALE                CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (41)         (47)         (43)                                                
      Adenocarcinoma, Metastatic, Uterus                                         1 (2%)                                             
      Basosquamous Tumor Malignant                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)                                                
      Adenocarcinoma                                   2 (4%)       5 (10%)      4 (8%)                                             
      Adenocarcinoma, Multiple                                      1 (2%)                                                          
      Fibroadenoma                                    23 (46%)     17 (34%)     20 (40%)                                            
      Fibroadenoma, Multiple                                        2 (4%)       2 (4%)                                             
      Fibrosarcoma                                                               1 (2%)                                             
   Skin                                               (48)         (49)         (49)                                                
      Fibroma                                                       1 (2%)                                                          
      Sarcoma                                                       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (2)                                                 
      Diaphragm, Adenocarcinoma, Metastatic, Uterus                              2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)                                                
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
      Granular Cell Tumor Benign                       2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (50)         (49)                                                
      Adenocarcinoma, Metastatic, Mammary Gland                     1 (2%)                                                          
      Adenocarcinoma, Metastatic, Uterus                                         2 (4%)                                             
      Basosquamous Tumor Malignant, Metastatic,                                                                                     
           Thymus                                      1 (2%)                                                                       
      Carcinoma Adenosquamous                                       1 (2%)                                                          
      Sarcoma, Metastatic, Uterus                                   1 (2%)                                                          
   Nose                                               (49)         (48)         (47)                                                
      Respiratory Epithelium, Adenoma, Papillary                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 05080-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         OSBORNE MENDEL RATS FEMALE                CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (48)         (49)                                                
      Adenocarcinoma, Metastatic, Uterus                                         1 (2%)                                             
      Liposarcoma                                                   1 (2%)                                                          
      Nephroblastoma                                                             1 (2%)                                             
   Urinary Bladder                                    (49)         (47)         (47)                                                
      Adenocarcinoma, Metastatic, Uterus                                         1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant                                            1 (2%)       1 (2%)                                             
      Lymphoma Malignant Histiocytic                   1 (2%)                                                                       
      Lymphoma Malignant Undifferentiated Cell                      1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05080-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         OSBORNE MENDEL RATS FEMALE                CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            43          47          44                                                   
     Total Primary Neoplasms                          103         107          94                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 40          44          37                                                   
     Total Benign Neoplasms                            91          88          74                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              12          19          17                                                   
     Total Malignant Neoplasms                         12          19          20                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           3           3                                                   
     Total Metastatic Neoplasm                          3           3          22                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05080-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         OSBORNE MENDEL RATS MALE                  CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                              27           27           29                                                  
    Moribund                                          11           12           13                                                  
  Survivors                                                                                                                         
    Moribund                                                        1                                                               
    Terminal Sacrifice                                12           10            8                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (23)         (21)         (15)                                                
   Intestine Large, Colon                             (39)         (38)         (34)                                                
   Intestine Large, Rectum                            (40)         (42)         (38)                                                
   Intestine Small, Duodenum                          (33)         (37)         (33)                                                
   Intestine Small, Ileum                             (24)         (27)         (23)                                                
   Intestine Small, Jejunum                           (24)         (27)         (25)                                                
      Adenocarcinoma, Mucinous                         1 (4%)                                                                       
   Liver                                              (49)         (49)         (47)                                                
      Adenoma                                                       1 (2%)                                                          
      Hepatocellular Carcinoma                                      1 (2%)                                                          
   Pancreas                                           (48)         (48)         (44)                                                
   Salivary Glands                                    (50)         (46)         (47)                                                
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
   Stomach, Forestomach                               (45)         (43)         (44)                                                
      Squamous Cell Carcinoma                          1 (2%)       2 (5%)       1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (48)         (48)         (46)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)         (48)         (48)                                                
      Adenoma                                          1 (2%)       1 (2%)       2 (4%)                                             
      Carcinoma                                        1 (2%)                                                                       
   Adrenal Gland, Medulla                             (47)         (47)         (47)                                                
      Pheochromocytoma Malignant                       5 (11%)                   3 (6%)                                             
      Pheochromocytoma Malignant, Multiple             2 (4%)                    1 (2%)                                             
                                                             Page   7                                                               
NTP Experiment-Test: 05080-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         OSBORNE MENDEL RATS MALE                  CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Benign                          9 (19%)      7 (15%)     12 (26%)                                            
      Pheochromocytoma Benign, Multiple                1 (2%)       7 (15%)      2 (4%)                                             
      Bilateral, Pheochromocytoma Benign               1 (2%)                                                                       
   Islets, Pancreatic                                 (48)         (48)         (45)                                                
      Adenoma                                                       2 (4%)       1 (2%)                                             
   Parathyroid Gland                                  (36)         (30)         (38)                                                
      Adenoma                                          1 (3%)                    2 (5%)                                             
   Pituitary Gland                                    (47)         (46)         (44)                                                
      Pars Distalis, Adenoma                          11 (23%)     12 (26%)     13 (30%)                                            
      Pars Distalis, Carcinoma                         2 (4%)                                                                       
      Pars Intermedia, Adenoma                                      2 (4%)       2 (5%)                                             
   Thyroid Gland                                      (43)         (46)         (46)                                                
      C-Cell, Adenoma                                  8 (19%)      9 (20%)     10 (22%)                                            
      C-Cell, Adenoma, Multiple                                     1 (2%)       2 (4%)                                             
      C-Cell, Carcinoma                                5 (12%)      1 (2%)       3 (7%)                                             
      Follicular Cell, Adenoma                                      1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (49)         (48)         (46)                                                
   Prostate                                           (49)         (49)         (46)                                                
      Sarcoma, Metastatic, Seminal Vesicle                          1 (2%)                                                          
   Seminal Vesicle                                    (49)         (49)         (45)                                                
      Sarcoma                                                       1 (2%)                                                          
   Testes                                             (49)         (49)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (46)         (48)         (44)                                                
   Lymph Node                                         (48)         (44)         (45)                                                
   Lymph Node, Bronchial                              (40)         (29)         (38)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (3%)                                                                       
   Lymph Node, Mandibular                             (44)         (40)         (42)                                                
      Carcinoma, Metastatic, Harderian Gland                        1 (3%)                                                          
   Spleen                                             (50)         (49)         (46)                                                
   Thymus                                             (46)         (46)         (44)                                                
      Carcinoma, Metastatic, Uncertain Primary Site                              1 (2%)                                             
      Thymoma Malignant                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05080-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         OSBORNE MENDEL RATS MALE                  CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (27)         (40)         (32)                                                
      Fibroadenoma                                                               2 (6%)                                             
   Skin                                               (49)         (49)         (49)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Fibroma                                          2 (4%)                    1 (2%)                                             
      Hemangioma                                                    1 (2%)                                                          
      Keratoacanthoma                                               1 (2%)                                                          
      Sarcoma                                                       2 (4%)                                                          
      Lip, Squamous Cell Carcinoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)                                                
      Cranium, Schwannoma Malignant, Metastatic,                                                                                    
           Brain                                                    1 (2%)                                                          
      Cranium, Squamous Cell Carcinoma, Metastatic,                                                                                 
           Nose                                                                  1 (2%)                                             
   Skeletal Muscle                                    (1)          (1)                                                              
      Sarcoma, Metastatic, Skin                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Oligodendroglioma Malignant                                                1 (2%)                                             
      Schwannoma Malignant                                          1 (2%)                                                          
      Meninges, Granular Cell Tumor Benign             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (39)         (45)         (43)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (3%)                                                                       
   Lung                                               (42)         (48)         (45)                                                
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic           1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                                     1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Brain                       1 (2%)                                                          
   Nose                                               (44)         (46)         (43)                                                
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Olfactory Epithelium, Adenocarcinoma, Poorly                                                                                  
          Differentiated                                                         1 (2%)                                             
      Respiratory Epithelium, Adenoma, Papillary                                 1 (2%)                                             
      Respiratory Epithelium, Squamous Cell                                                                                         
                                                             Page   9                                                               
NTP Experiment-Test: 05080-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         OSBORNE MENDEL RATS MALE                  CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
          Carcinoma                                                              1 (2%)                                             
   Trachea                                            (40)         (45)         (42)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)          (2)                                                 
   Harderian Gland                                    (3)          (2)          (8)                                                 
      Carcinoma                                                     1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (48)                                                
      Adenoma                                          1 (2%)                                                                       
      Adenoma, Multiple                                1 (2%)                                                                       
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
   Urinary Bladder                                    (46)         (49)         (44)                                                
      Sarcoma, Metastatic, Seminal Vesicle                          1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant                               1 (2%)       1 (2%)       1 (2%)                                             
      Lymphoma Malignant Histiocytic                   1 (2%)       1 (2%)       1 (2%)                                             
      Lymphoma Malignant Undifferentiated Cell         1 (2%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05080-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:51:06  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         OSBORNE MENDEL RATS MALE                  CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            30          37          38                                                   
     Total Primary Neoplasms                           59          57          67                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 25          31          32                                                   
     Total Benign Neoplasms                            38          45          51                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          12          14                                                   
     Total Malignant Neoplasms                         21          12          16                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           4           2                                                   
     Total Metastatic Neoplasm                          7          10           2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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