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TDMS Study 05080-01 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                   ALLYL GLYCIDYL ETHER                                 DATE: 09/10/94       
EXPERIMENT: 05080 TEST: 01                                                                                     TIME: 19:04:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01ES38061            ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 56666        
PATHOLOGIST: R. RENNE                                                                                          CAS: 106-92-3        
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Battelle Northwest                                   ALLYL GLYCIDYL ETHER                                 DATE: 09/10/94      
EXPERIMENT: 05080 TEST: 01                                                                                     TIME: 19:04:10      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01ES38061            ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 56666       
PATHOLOGIST: R. RENNE                                                                                          CAS: 106-92-3       
 
 
 
 
 
                                                    RATS(OSBORNE MENDEL)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                   ALLYL GLYCIDYL ETHER                                 DATE: 09/10/94       
EXPERIMENT: 05080 TEST: 01                                                                                     TIME: 19:04:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES38061            ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 56666        
PATHOLOGIST: R. RENNE                                                                                          CAS: 106-92-3        
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                      IN THE ANALYSIS OF THE STUDY OF ALLYL GLYCIDYL ETHER
 
              ====================================================================================================
 
                                                           MALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Adrenal Medulla               Pheochromocytoma Malignant
                             Thyroid Gland: C-Cell         Adenoma
                                                           Carcinoma or Adenoma
                             All Organs                    Benign Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
 
                                                           FEMALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Islets, Pancreatic            Adenoma
                                                           Carcinoma or Adenoma
                             All Organs                    Malignant Tumors
 
              ====================================================================================================
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE   1
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/48 (2%)       1/48 (2%)       2/48 (4%)      |     3/50 (6%)       6/49 (12%)      2/49 (4%)      |
|ADJUSTED (b)           |      6.7%            6.7%           10.8%          |     10.3%           17.2%            6.5%          |
|TERMINAL (d)           |     0/12 (0%)       0/11 (0%)       0/8 (0%)       |     2/24 (8%)       3/30 (10%)      1/25 (4%)      |
|FIRST INCIDENCE (DAYS) |      731             689             570           |      521             579             624           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.239         P=0.687         P=0.353        |     P=0.430N        P=0.305         P=0.497N       |
|INCIDENTAL TUMOR       |     P=0.329         P=0.732         P=0.469        |     P=0.478N        P=0.204         P=0.567N       |
|LOGISTIC REGRESSION    |     P=0.328         P=0.724         P=0.456        |     P=0.449N        P=0.231         P=0.517N       |
|COCHRAN-ARMITAGE       |     P=0.378                                        |     P=0.435N                                       |
|FISHER EXACT           |                     P=0.753N        P=0.500        |                     P=0.233         P=0.510N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    11/47 (23%)     14/47 (30%)     14/47 (30%)     |     6/49 (12%)      2/48 (4%)       6/47 (13%)     |
|ADJUSTED (b)           |     60.7%           62.1%           50.7%          |     21.1%            6.7%           22.9%          |
|TERMINAL (d)           |     6/12 (50%)      4/11 (36%)      1/8 (13%)      |     3/24 (13%)      2/30 (7%)       5/24 (21%)     |
|FIRST INCIDENCE (DAYS) |      586             500             303           |      667             737 (T)         624           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.069         P=0.197         P=0.099        |     P=0.564         P=0.090N        P=0.612        |
|INCIDENTAL TUMOR       |     P=0.246         P=0.243         P=0.375        |     P=0.525         P=0.195N        P=0.575        |
|LOGISTIC REGRESSION    |     P=0.184         P=0.227         P=0.241        |     P=0.512         P=0.126N        P=0.557        |
|COCHRAN-ARMITAGE       |     P=0.282                                        |     P=0.542                                        |
|FISHER EXACT           |                     P=0.321         P=0.321        |                     P=0.141N        P=0.590        |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE   2
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/47 (15%)      0/47 (0%)       4/47 (9%)      |     0/49 (0%)       0/48 (0%)       0/47 (0%)      |
|ADJUSTED (b)           |     36.6%            0.0%           32.2%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     3/12 (25%)      0/11 (0%)       2/8 (25%)      |     0/24 (0%)       0/30 (0%)       0/24 (0%)      |
|FIRST INCIDENCE (DAYS) |      604             ---             593           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.355N        P=0.019N*       P=0.544N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.245N        P=0.013N*       P=0.397N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.264N        P=0.012N*       P=0.414N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.168N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.006N**      P=0.261N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    17/47 (36%)     14/47 (30%)     18/47 (38%)     |     6/49 (12%)      2/48 (4%)       6/47 (13%)     |
|ADJUSTED (b)           |     77.8%           62.1%           68.2%          |     21.1%            6.7%           22.9%          |
|TERMINAL (d)           |     8/12 (67%)      4/11 (36%)      3/8 (38%)      |     3/24 (13%)      2/30 (7%)       5/24 (21%)     |
|FIRST INCIDENCE (DAYS) |      586             500             303           |      667             737 (T)         624           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.106         P=0.537N        P=0.122        |     P=0.564         P=0.090N        P=0.612        |
|INCIDENTAL TUMOR       |     P=0.365         P=0.419N        P=0.471        |     P=0.525         P=0.195N        P=0.575        |
|LOGISTIC REGRESSION    |     P=0.297         P=0.425N        P=0.347        |     P=0.512         P=0.126N        P=0.557        |
|COCHRAN-ARMITAGE       |     P=0.457                                        |     P=0.542                                        |
|FISHER EXACT           |                     P=0.331N        P=0.500        |                     P=0.141N        P=0.590        |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE   3
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Granular Cell Tumor Benign                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       0/50 (0%)       0/50 (0%)      |     2/49 (4%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      3.1%            0.0%            0.0%          |      6.6%            0.0%            0.0%          |
|TERMINAL (d)           |     0/12 (0%)       0/11 (0%)       0/8 (0%)       |     1/23 (4%)       0/30 (0%)       0/25 (0%)      |
|FIRST INCIDENCE (DAYS) |      604             ---             ---           |      579             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.301N        P=0.513N        P=0.549N       |     P=0.092N        P=0.213N        P=0.239N       |
|INCIDENTAL TUMOR       |     P=0.220N        P=0.500N        P=0.419N       |     P=0.083N        P=0.181N        P=0.231N       |
|LOGISTIC REGRESSION    |     P=0.264N        P=0.496N        P=0.497N       |     P=0.093N        P=0.233N        P=0.234N       |
|COCHRAN-ARMITAGE       |     P=0.269N                                       |     P=0.093N                                       |
|FISHER EXACT           |                     P=0.500N        P=0.500N       |                     P=0.242N        P=0.242N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/48 (0%)       2/48 (4%)       1/45 (2%)      |     4/50 (8%)       0/48 (0%)       0/48 (0%)      |
|ADJUSTED (b)           |      0.0%           18.2%           12.5%          |     15.2%            0.0%            0.0%          |
|TERMINAL (d)           |     0/12 (0%)       2/11 (18%)      1/8 (13%)      |     3/24 (13%)      0/30 (0%)       0/25 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             737 (T)         737 (T)       |      705             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.252         P=0.216         P=0.419        |     P=0.013N*       P=0.044N*       P=0.062N       |
|INCIDENTAL TUMOR       |     P=0.252         P=0.216         P=0.419        |     P=0.016N*       P=0.062N        P=0.065N       |
|LOGISTIC REGRESSION    |     P=0.252         P=0.216         P=0.419        |     P=0.015N*       P=0.056N        P=0.065N       |
|COCHRAN-ARMITAGE       |     P=0.343                                        |     P=0.016N*                                      |
|FISHER EXACT           |                     P=0.247         P=0.484        |                     P=0.064N        P=0.064N       |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE   4
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/48 (0%)       2/48 (4%)       1/45 (2%)      |     4/50 (8%)       1/48 (2%)       0/48 (0%)      |
|ADJUSTED (b)           |      0.0%           18.2%           12.5%          |     15.2%            3.3%            0.0%          |
|TERMINAL (d)           |     0/12 (0%)       2/11 (18%)      1/8 (13%)      |     3/24 (13%)      1/30 (3%)       0/25 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             737 (T)         737 (T)       |      705             737 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.252         P=0.216         P=0.419        |     P=0.021N*       P=0.129N        P=0.062N       |
|INCIDENTAL TUMOR       |     P=0.252         P=0.216         P=0.419        |     P=0.025N*       P=0.166N        P=0.065N       |
|LOGISTIC REGRESSION    |     P=0.252         P=0.216         P=0.419        |     P=0.025N*       P=0.160N        P=0.065N       |
|COCHRAN-ARMITAGE       |     P=0.343                                        |     P=0.028N*                                      |
|FISHER EXACT           |                     P=0.247         P=0.484        |                     P=0.194N        P=0.064N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       0/49 (0%)       0/48 (0%)      |     0/50 (0%)       0/48 (0%)       0/49 (0%)      |
|ADJUSTED (b)           |     13.4%            0.0%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     1/12 (8%)       0/11 (0%)       0/8 (0%)       |     0/24 (0%)       0/30 (0%)       0/25 (0%)      |
|FIRST INCIDENCE (DAYS) |      719             ---             ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.156N        P=0.294N        P=0.366N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.136N        P=0.265N        P=0.333N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.153N        P=0.297N        P=0.364N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.099N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.253N        P=0.258N       |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE   5
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/49 (0%)       1/49 (2%)       0/47 (0%)      |     3/50 (6%)       3/48 (6%)       1/49 (2%)      |
|ADJUSTED (b)           |      0.0%            9.1%            0.0%          |     12.5%           10.0%            4.0%          |
|TERMINAL (d)           |     0/12 (0%)       1/11 (9%)       0/8 (0%)       |     3/24 (13%)      3/30 (10%)      1/25 (4%)      |
|FIRST INCIDENCE (DAYS) |      ---             737 (T)         ---           |      737 (T)         737 (T)         737 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.680         P=0.483           (e)          |     P=0.214N        P=0.557N        P=0.288N       |
|INCIDENTAL TUMOR       |     P=0.680         P=0.483           (e)          |     P=0.214N        P=0.557N        P=0.288N       |
|LOGISTIC REGRESSION    |     P=0.680         P=0.483           (e)          |     P=0.214N        P=0.557N        P=0.288N       |
|COCHRAN-ARMITAGE       |     P=0.726                                        |     P=0.247N                                       |
|FISHER EXACT           |                     P=0.500           (e)          |                     P=0.641         P=0.316N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/49 (0%)       2/49 (4%)       0/47 (0%)      |     3/50 (6%)       3/48 (6%)       1/49 (2%)      |
|ADJUSTED (b)           |      0.0%           13.2%            0.0%          |     12.5%           10.0%            4.0%          |
|TERMINAL (d)           |     0/12 (0%)       1/11 (9%)       0/8 (0%)       |     3/24 (13%)      3/30 (10%)      1/25 (4%)      |
|FIRST INCIDENCE (DAYS) |      ---             659             ---           |      737 (T)         737 (T)         737 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.581         P=0.216           (e)          |     P=0.214N        P=0.557N        P=0.288N       |
|INCIDENTAL TUMOR       |     P=0.574         P=0.215           (e)          |     P=0.214N        P=0.557N        P=0.288N       |
|LOGISTIC REGRESSION    |     P=0.591         P=0.206           (e)          |     P=0.214N        P=0.557N        P=0.288N       |
|COCHRAN-ARMITAGE       |     P=0.660                                        |     P=0.247N                                       |
|FISHER EXACT           |                     P=0.247           (e)          |                     P=0.641         P=0.316N       |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE   6
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/49 (0%)       2/49 (4%)       0/47 (0%)      |     3/50 (6%)       3/48 (6%)       1/49 (2%)      |
|ADJUSTED (b)           |      0.0%           13.2%            0.0%          |     12.5%           10.0%            4.0%          |
|TERMINAL (d)           |     0/12 (0%)       1/11 (9%)       0/8 (0%)       |     3/24 (13%)      3/30 (10%)      1/25 (4%)      |
|FIRST INCIDENCE (DAYS) |      ---             659             ---           |      737 (T)         737 (T)         737 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.581         P=0.216           (e)          |     P=0.214N        P=0.557N        P=0.288N       |
|INCIDENTAL TUMOR       |     P=0.574         P=0.215           (e)          |     P=0.214N        P=0.557N        P=0.288N       |
|LOGISTIC REGRESSION    |     P=0.591         P=0.206           (e)          |     P=0.214N        P=0.557N        P=0.288N       |
|COCHRAN-ARMITAGE       |     P=0.660                                        |     P=0.247N                                       |
|FISHER EXACT           |                     P=0.247           (e)          |                     P=0.641         P=0.316N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     2/50 (4%)       6/50 (12%)      4/50 (8%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      5.4%           16.7%           12.1%          |
|TERMINAL (d)           |     0/12 (0%)       0/11 (0%)       0/8 (0%)       |     0/24 (0%)       2/30 (7%)       2/25 (8%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      569             318             269           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.290         P=0.179         P=0.339        |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.359         P=0.066         P=0.409        |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.317         P=0.137         P=0.378        |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.290                                        |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.134         P=0.339        |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE   7
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       2/50 (4%)      |    23/50 (46%)     19/50 (38%)     22/50 (44%)     |
|ADJUSTED (b)           |      0.0%            0.0%            6.8%          |     60.0%           48.4%           59.8%          |
|TERMINAL (d)           |     0/12 (0%)       0/11 (0%)       0/8 (0%)       |    10/24 (42%)     11/30 (37%)     11/25 (44%)     |
|FIRST INCIDENCE (DAYS) |      ---             ---             520           |      474             471             332           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.085           (e)           P=0.214        |     P=0.469N        P=0.175N        P=0.501N       |
|INCIDENTAL TUMOR       |     P=0.099           (e)           P=0.249        |     P=0.462         P=0.287N        P=0.476        |
|LOGISTIC REGRESSION    |     P=0.104           (e)           P=0.254        |     P=0.510N        P=0.277N        P=0.556N       |
|COCHRAN-ARMITAGE       |     P=0.095                                        |     P=0.460N                                       |
|FISHER EXACT           |                       (e)           P=0.247        |                     P=0.272N        P=0.500N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       2/50 (4%)      |    25/50 (50%)     24/50 (48%)     26/50 (52%)     |
|ADJUSTED (b)           |      0.0%            0.0%            6.8%          |     62.2%           56.4%           67.1%          |
|TERMINAL (d)           |     0/12 (0%)       0/11 (0%)       0/8 (0%)       |    10/24 (42%)     12/30 (40%)     13/25 (52%)     |
|FIRST INCIDENCE (DAYS) |      ---             ---             520           |      474             318             269           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.085           (e)           P=0.214        |     P=0.461         P=0.333N        P=0.498        |
|INCIDENTAL TUMOR       |     P=0.099           (e)           P=0.249        |     P=0.344         P=0.554         P=0.355        |
|LOGISTIC REGRESSION    |     P=0.104           (e)           P=0.254        |     P=0.427         P=0.576         P=0.462        |
|COCHRAN-ARMITAGE       |     P=0.095                                        |     P=0.460                                        |
|FISHER EXACT           |                       (e)           P=0.247        |                     P=0.500N        P=0.500        |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE   8
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/36 (3%)       0/30 (0%)       2/38 (5%)      |     0/26 (0%)       0/32 (0%)       0/33 (0%)      |
|ADJUSTED (b)           |      3.3%            0.0%            5.1%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/10 (0%)       0/8 (0%)        0/6 (0%)       |     0/8 (0%)        0/18 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      609             ---             303           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.330         P=0.507N        P=0.458        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.593         P=0.521N        P=0.726        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.543         P=0.540N        P=0.681        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.379                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.545N        P=0.521        |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    11/47 (23%)     12/46 (26%)     13/44 (30%)     |    26/50 (52%)     26/45 (58%)     20/48 (42%)     |
|ADJUSTED (b)           |     56.3%           55.9%           61.2%          |     67.4%           71.6%           71.1%          |
|TERMINAL (d)           |     4/11 (36%)      3/10 (30%)      2/7 (29%)      |    12/24 (50%)     18/28 (64%)     17/25 (68%)     |
|FIRST INCIDENCE (DAYS) |      578             591             568           |      478             569             658           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.093         P=0.343         P=0.120        |     P=0.137N        P=0.380N        P=0.165N       |
|INCIDENTAL TUMOR       |     P=0.269         P=0.407         P=0.293        |     P=0.157N        P=0.321         P=0.187N       |
|LOGISTIC REGRESSION    |     P=0.167         P=0.397         P=0.202        |     P=0.185N        P=0.376         P=0.212N       |
|COCHRAN-ARMITAGE       |     P=0.293                                        |     P=0.182N                                       |
|FISHER EXACT           |                     P=0.476         P=0.335        |                     P=0.360         P=0.206N       |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE   9
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/47 (4%)       0/46 (0%)       0/44 (0%)      |     1/50 (2%)       0/45 (0%)       1/48 (2%)      |
|ADJUSTED (b)           |     14.1%            0.0%            0.0%          |      2.9%            0.0%            2.4%          |
|TERMINAL (d)           |     1/11 (9%)       0/10 (0%)       0/7 (0%)       |     0/24 (0%)       0/28 (0%)       0/25 (0%)      |
|FIRST INCIDENCE (DAYS) |      719             ---             ---           |      683             ---             570           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.158N        P=0.295N        P=0.372N       |     P=0.661         P=0.506N        P=0.754        |
|INCIDENTAL TUMOR       |     P=0.137N        P=0.259N        P=0.342N       |     P=0.640         P=0.654N        P=0.742        |
|LOGISTIC REGRESSION    |     P=0.160N        P=0.299N        P=0.382N       |     P=0.665         P=0.521N        P=0.761        |
|COCHRAN-ARMITAGE       |     P=0.101N                                       |     P=0.658                                        |
|FISHER EXACT           |                     P=0.253N        P=0.264N       |                     P=0.526N        P=0.742        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    13/47 (28%)     12/46 (26%)     13/44 (30%)     |    27/50 (54%)     26/45 (58%)     21/48 (44%)     |
|ADJUSTED (b)           |     64.6%           55.9%           61.2%          |     68.4%           71.6%           71.8%          |
|TERMINAL (d)           |     5/11 (45%)      3/10 (30%)      2/7 (29%)      |    12/24 (50%)     18/28 (64%)     17/25 (68%)     |
|FIRST INCIDENCE (DAYS) |      578             591             568           |      478             569             570           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.171         P=0.492         P=0.201        |     P=0.144N        P=0.320N        P=0.175N       |
|INCIDENTAL TUMOR       |     P=0.427         P=0.594         P=0.440        |     P=0.160N        P=0.371         P=0.194N       |
|LOGISTIC REGRESSION    |     P=0.299         P=0.581         P=0.335        |     P=0.192N        P=0.456         P=0.222N       |
|COCHRAN-ARMITAGE       |     P=0.469                                        |     P=0.183N                                       |
|FISHER EXACT           |                     P=0.525N        P=0.513        |                     P=0.435         P=0.208N       |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE  10
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/47 (0%)       2/46 (4%)       2/44 (5%)      |     0/50 (0%)       0/45 (0%)       0/48 (0%)      |
|ADJUSTED (b)           |      0.0%           20.0%           16.3%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/11 (0%)       2/10 (20%)      1/7 (14%)      |     0/24 (0%)       0/28 (0%)       0/25 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             737 (T)         520           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.108         P=0.213         P=0.195        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.079         P=0.213         P=0.126        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.118         P=0.213         P=0.217        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.161                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.242         P=0.231        |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       0/50 (0%)       1/50 (2%)      |     0/50 (0%)       1/50 (2%)       0/50 (0%)      |
|ADJUSTED (b)           |      9.0%            0.0%            5.6%          |      0.0%            3.3%            0.0%          |
|TERMINAL (d)           |     0/12 (0%)       0/11 (0%)       0/8 (0%)       |     0/24 (0%)       1/30 (3%)       0/25 (0%)      |
|FIRST INCIDENCE (DAYS) |      327             ---             652           |      ---             737 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.457N        P=0.269N        P=0.621N       |     P=0.732N        P=0.545           (e)          |
|INCIDENTAL TUMOR       |     P=0.272N        P=0.255N        P=0.432N       |     P=0.732N        P=0.545           (e)          |
|LOGISTIC REGRESSION    |     P=0.326N        P=0.217N        P=0.463N       |     P=0.732N        P=0.545           (e)          |
|COCHRAN-ARMITAGE       |     P=0.360N                                       |     P=0.731                                        |
|FISHER EXACT           |                     P=0.247N        P=0.500N       |                     P=0.500           (e)          |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE  11
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            4.5%            0.0%          |      0.0%            5.5%            0.0%          |
|TERMINAL (d)           |     0/12 (0%)       0/11 (0%)       0/8 (0%)       |     0/24 (0%)       1/30 (3%)       0/25 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             444             ---           |      ---             547             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.666         P=0.242           (e)          |     P=0.669N        P=0.267           (e)          |
|INCIDENTAL TUMOR       |     P=0.629         P=0.307           (e)          |     P=0.670N        P=0.297           (e)          |
|LOGISTIC REGRESSION    |     P=0.575N        P=0.260           (e)          |     P=0.665N        P=0.240           (e)          |
|COCHRAN-ARMITAGE       |     P=0.669                                        |     P=0.669                                        |
|FISHER EXACT           |                     P=0.247           (e)          |                     P=0.247           (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       2/50 (4%)       1/50 (2%)      |     0/50 (0%)       1/50 (2%)       0/50 (0%)      |
|ADJUSTED (b)           |      8.3%            5.1%           12.5%          |      0.0%            2.1%            0.0%          |
|TERMINAL (d)           |     1/12 (8%)       0/11 (0%)       1/8 (13%)      |     0/24 (0%)       0/30 (0%)       0/25 (0%)      |
|FIRST INCIDENCE (DAYS) |      737 (T)         526             737 (T)       |      ---             396             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.556         P=0.481         P=0.672        |     P=0.716         P=0.496           (e)          |
|INCIDENTAL TUMOR       |     P=0.577         P=0.526         P=0.672        |     P=0.601         P=0.398           (e)          |
|LOGISTIC REGRESSION    |     P=0.598         P=0.506         P=0.672        |     P=0.645N        P=0.541           (e)          |
|COCHRAN-ARMITAGE       |     P=0.622N                                       |     P=0.731                                        |
|FISHER EXACT           |                     P=0.500         P=0.753N       |                     P=0.500           (e)          |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE  12
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       2/50 (4%)       1/50 (2%)      |     0/50 (0%)       1/50 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |     12.5%            5.1%           12.5%          |      0.0%            2.1%            2.9%          |
|TERMINAL (d)           |     1/12 (8%)       0/11 (0%)       1/8 (13%)      |     0/24 (0%)       0/30 (0%)       0/25 (0%)      |
|FIRST INCIDENCE (DAYS) |      684             526             737 (T)       |      ---             396             652           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.501N        P=0.643         P=0.672N       |     P=0.318         P=0.496         P=0.494        |
|INCIDENTAL TUMOR       |     P=0.461N        P=0.685N        P=0.641N       |     P=0.232         P=0.398         P=0.467        |
|LOGISTIC REGRESSION    |     P=0.428N        P=0.694         P=0.674N       |     P=0.390         P=0.541         P=0.500        |
|COCHRAN-ARMITAGE       |     P=0.390N                                       |     P=0.331                                        |
|FISHER EXACT           |                     P=0.691N        P=0.500N       |                     P=0.500         P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     8/43 (19%)     10/46 (22%)     12/46 (26%)     |    11/49 (22%)     19/47 (40%)     12/47 (26%)     |
|ADJUSTED (b)           |     40.6%           52.8%           61.4%          |     36.7%           55.2%           40.1%          |
|TERMINAL (d)           |     3/12 (25%)      4/11 (36%)      3/8 (38%)      |     6/24 (25%)     15/30 (50%)      8/25 (32%)     |
|FIRST INCIDENCE (DAYS) |      586             531             593           |      690             547             624           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.036 *       P=0.263         P=0.049 *      |     P=0.478         P=0.175         P=0.516        |
|INCIDENTAL TUMOR       |     P=0.140         P=0.371         P=0.225        |     P=0.411         P=0.051         P=0.454        |
|LOGISTIC REGRESSION    |     P=0.092         P=0.346         P=0.126        |     P=0.379         P=0.053         P=0.440        |
|COCHRAN-ARMITAGE       |     P=0.235                                        |     P=0.404                                        |
|FISHER EXACT           |                     P=0.459         P=0.278        |                     P=0.046 *       P=0.454        |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE  13
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/43 (12%)      1/46 (2%)       3/46 (7%)      |     4/49 (8%)       2/47 (4%)       4/47 (9%)      |
|ADJUSTED (b)           |     32.5%            9.1%           28.7%          |     16.7%            5.9%           13.2%          |
|TERMINAL (d)           |     2/12 (17%)      1/11 (9%)       1/8 (13%)      |     4/24 (17%)      1/30 (3%)       1/25 (4%)      |
|FIRST INCIDENCE (DAYS) |      719             737 (T)         681           |      737 (T)         642             624           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.495N        P=0.150N        P=0.644        |     P=0.570N        P=0.253N        P=0.628N       |
|INCIDENTAL TUMOR       |     P=0.449N        P=0.119N        P=0.606N       |     P=0.553         P=0.244N        P=0.621        |
|LOGISTIC REGRESSION    |     P=0.525N        P=0.166N        P=0.646        |     P=0.546         P=0.332N        P=0.615        |
|COCHRAN-ARMITAGE       |     P=0.235N                                       |     P=0.557                                        |
|FISHER EXACT           |                     P=0.087N        P=0.319N       |                     P=0.359N        P=0.619        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    11/43 (26%)     11/46 (24%)     15/46 (33%)     |    14/49 (29%)     21/47 (45%)     14/47 (30%)     |
|ADJUSTED (b)           |     54.7%           59.5%           74.9%          |     47.2%           59.3%           45.6%          |
|TERMINAL (d)           |     4/12 (33%)      5/11 (45%)      4/8 (50%)      |     9/24 (38%)     16/30 (53%)      9/25 (36%)     |
|FIRST INCIDENCE (DAYS) |      586             531             593           |      690             547             624           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.028 *       P=0.424         P=0.036 *      |     P=0.517N        P=0.274         P=0.563N       |
|INCIDENTAL TUMOR       |     P=0.102         P=0.563         P=0.151        |     P=0.498         P=0.107         P=0.549        |
|LOGISTIC REGRESSION    |     P=0.061         P=0.515         P=0.079        |     P=0.460         P=0.087         P=0.531        |
|COCHRAN-ARMITAGE       |     P=0.262                                        |     P=0.484                                        |
|FISHER EXACT           |                     P=0.525N        P=0.311        |                     P=0.077         P=0.537        |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE  14
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     2/50 (4%)       0/50 (0%)       3/50 (6%)      |
|ADJUSTED (b)           |                                                    |      7.3%            0.0%            9.1%          |
|TERMINAL (d)           |                                                    |     0/24 (0%)       0/30 (0%)       1/25 (4%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      723             ---             578           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.385         P=0.206N        P=0.493        |
|INCIDENTAL TUMOR       |                                                    |     P=0.356         P=0.418N        P=0.458        |
|LOGISTIC REGRESSION    |                                                    |     P=0.376         P=0.226N        P=0.482        |
|COCHRAN-ARMITAGE       |                                                    |     P=0.390                                        |
|FISHER EXACT           |                                                    |                     P=0.247N        P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |    10/50 (20%)     11/50 (22%)      9/50 (18%)     |
|ADJUSTED (b)           |                                                    |     34.7%           31.0%           33.8%          |
|TERMINAL (d)           |                                                    |     6/24 (25%)      7/30 (23%)      8/25 (32%)     |
|FIRST INCIDENCE (DAYS) |                                                    |      690             318             624           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.433N        P=0.519N        P=0.478N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.390N        P=0.462         P=0.505N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.502N        P=0.494         P=0.537N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.450N                                       |
|FISHER EXACT           |                                                    |                     P=0.500         P=0.500N       |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE  15
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     1/50 (2%)       2/50 (4%)       1/50 (2%)      |
|ADJUSTED (b)           |                                                    |      2.4%            5.4%            3.6%          |
|TERMINAL (d)           |                                                    |     0/24 (0%)       1/30 (3%)       0/25 (0%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      579             408             729           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.616         P=0.518         P=0.760        |
|INCIDENTAL TUMOR       |                                                    |     P=0.536         P=0.501         P=0.742        |
|LOGISTIC REGRESSION    |                                                    |     P=0.598N        P=0.519         P=0.763        |
|COCHRAN-ARMITAGE       |                                                    |     P=0.622N                                       |
|FISHER EXACT           |                                                    |                     P=0.500         P=0.753N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |    11/50 (22%)     13/50 (26%)     10/50 (20%)     |
|ADJUSTED (b)           |                                                    |     36.2%           35.4%           36.2%          |
|TERMINAL (d)           |                                                    |     6/24 (25%)      8/30 (27%)      8/25 (32%)     |
|FIRST INCIDENCE (DAYS) |                                                    |      579             318             624           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.439N        P=0.577         P=0.479N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.429N        P=0.372         P=0.513N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.502N        P=0.403         P=0.549N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.452N                                       |
|FISHER EXACT           |                                                    |                     P=0.408         P=0.500N       |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE  16
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       3/50 (6%)       4/50 (8%)      |     1/50 (2%)       2/50 (4%)       2/50 (4%)      |
|ADJUSTED (b)           |     12.8%           16.5%           13.7%          |      3.0%            5.9%            4.8%          |
|TERMINAL (d)           |     1/12 (8%)       0/11 (0%)       0/8 (0%)       |     0/24 (0%)       0/30 (0%)       0/25 (0%)      |
|FIRST INCIDENCE (DAYS) |      449             635             580           |      690             674             281           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.282         P=0.591         P=0.408        |     P=0.379         P=0.512         P=0.494        |
|INCIDENTAL TUMOR       |     P=0.482         P=0.656         P=0.604        |     P=0.414         P=0.233         P=0.581        |
|LOGISTIC REGRESSION    |     P=0.409         P=0.659         P=0.521        |     P=0.425         P=0.499         P=0.576        |
|COCHRAN-ARMITAGE       |     P=0.421                                        |     P=0.390                                        |
|FISHER EXACT           |                     P=0.661N        P=0.500        |                     P=0.500         P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       3/50 (6%)       4/50 (8%)      |     1/50 (2%)       2/50 (4%)       2/50 (4%)      |
|ADJUSTED (b)           |     12.8%           16.5%           13.7%          |      3.0%            5.9%            4.8%          |
|TERMINAL (d)           |     1/12 (8%)       0/11 (0%)       0/8 (0%)       |     0/24 (0%)       0/30 (0%)       0/25 (0%)      |
|FIRST INCIDENCE (DAYS) |      449             635             580           |      690             674             281           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.282         P=0.591         P=0.408        |     P=0.379         P=0.512         P=0.494        |
|INCIDENTAL TUMOR       |     P=0.482         P=0.656         P=0.604        |     P=0.414         P=0.233         P=0.581        |
|LOGISTIC REGRESSION    |     P=0.409         P=0.659         P=0.521        |     P=0.425         P=0.499         P=0.576        |
|COCHRAN-ARMITAGE       |     P=0.421                                        |     P=0.390                                        |
|FISHER EXACT           |                     P=0.661N        P=0.500        |                     P=0.500         P=0.500        |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE  17
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    25/50 (50%)     31/50 (62%)     32/50 (64%)     |    40/50 (80%)     44/50 (88%)     37/50 (74%)     |
|ADJUSTED (b)           |     88.2%          100.0%           93.6%          |     90.8%           95.6%           92.3%          |
|TERMINAL (d)           |     9/12 (75%)     11/11 (100%)     6/8 (75%)      |    20/24 (83%)     28/30 (93%)     22/25 (88%)     |
|FIRST INCIDENCE (DAYS) |      327             500             303           |      474             318             332           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.004 **      P=0.071         P=0.007 **     |     P=0.333N        P=0.451N        P=0.364N       |
|INCIDENTAL TUMOR       |     P=0.016 *       P=0.049 *       P=0.039 *      |     P=0.429N        P=0.191         P=0.593N       |
|LOGISTIC REGRESSION    |     P=0.010 **      P=0.054         P=0.022 *      |     P=0.465N        P=0.146         P=0.516N       |
|COCHRAN-ARMITAGE       |     P=0.093                                        |     P=0.263N                                       |
|FISHER EXACT           |                     P=0.157         P=0.113        |                     P=0.207         P=0.318N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    18/50 (36%)     12/50 (24%)     15/50 (30%)     |    12/50 (24%)     19/50 (38%)     17/50 (34%)     |
|ADJUSTED (b)           |     79.6%           43.2%           64.3%          |     34.2%           45.3%           42.0%          |
|TERMINAL (d)           |     8/12 (67%)      1/11 (9%)       3/8 (38%)      |     4/24 (17%)      8/30 (27%)      4/25 (16%)     |
|FIRST INCIDENCE (DAYS) |      449             444             300           |      269             318             220           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.372         P=0.293N        P=0.358        |     P=0.196         P=0.210         P=0.223        |
|INCIDENTAL TUMOR       |     P=0.423N        P=0.165N        P=0.502N       |     P=0.178         P=0.042 *       P=0.258        |
|LOGISTIC REGRESSION    |     P=0.406N        P=0.171N        P=0.501N       |     P=0.194         P=0.100         P=0.222        |
|COCHRAN-ARMITAGE       |     P=0.293N                                       |     P=0.167                                        |
|FISHER EXACT           |                     P=0.138N        P=0.335N       |                     P=0.097         P=0.189        |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05080 TEST: 01                                                 PAGE  18
                        STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(OSBORNE MENDEL) -- ALLYL GLYCIDYL ETHER
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         5 PPM           10 PPM        |      CONTROL         5 PPM           10 PPM        |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    30/50 (60%)     37/50 (74%)     39/50 (78%)     |    43/50 (86%)     47/50 (94%)     44/50 (88%)     |
|ADJUSTED (b)           |     96.5%          100.0%           97.3%          |     93.4%           97.9%           95.5%          |
|TERMINAL (d)           |    11/12 (92%)     11/11 (100%)     7/8 (88%)      |    21/24 (88%)     29/30 (97%)     23/25 (92%)     |
|FIRST INCIDENCE (DAYS) |      327             444             300           |      269             318             220           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.002 **      P=0.058         P=0.003 **     |     P=0.473         P=0.442N        P=0.507        |
|INCIDENTAL TUMOR       |     P=0.004 **      P=0.034 *       P=0.009 **     |     P=0.315         P=0.155         P=0.398        |
|LOGISTIC REGRESSION    |     P=0.003 **      P=0.028 *       P=0.006 **     |     P=0.308         P=0.129         P=0.397        |
|COCHRAN-ARMITAGE       |     P=0.031 *                                      |     P=0.436                                        |
|FISHER EXACT           |                     P=0.101         P=0.041 *      |                     P=0.159         P=0.500        |
|=================================================================================================================================|
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).

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