TDMS Study 05080-01 Pathology Tables
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
Facility: Battelle Northwest
Chemical CAS #: 106-92-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 7| 3| 3| 2| 3| 2| 7| 0| 0| 3| 8| 3| 6| 3| 3| 3| 4| 3| 3| 4| 0| 3| 3| 3|
| 7| 9| 7| 7| 2| 7| 3| 8| 0| 5| 7| 3| 7| 9| 7| 7| 7| 1| 7| 7| 7| 5| 6| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M + M + + + + +|
Acanthosis | |
Hyperkeratosis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + M + + + + + A M + + M M M + + + M + + A + + + +|
Parasite Metazoan | 2 X |
__________________________________________________________________________|
Intestine Large, Colon | + A + + A + + + + + + + + + + + + + + + A + + + +|
Inflammation, Suppurative | 1 |
Parasite Metazoan | X 3 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + A + + + +|
Parasite Metazoan | 1 X |
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + M + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + A + + A + + + M + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + A + + A + + + M + + + + + + + + A + + + +|
Inflammation, Suppurative | |
Muscularis, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | 1 |
Eosinophilic Focus | 3 X|
Hematopoietic Cell Proliferation | 2 3 |
Leukocytosis | 4 |
Necrosis | 3 |
Vacuolization Cytoplasmic | 2 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Pharynx | + |
Necrosis | |
Ulcer | |
Epithelium, Hyperplasia | |
Palate, Ulcer | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | |
Karyomegaly | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 7| 3| 3| 2| 3| 2| 7| 0| 0| 3| 8| 3| 6| 3| 3| 3| 4| 3| 3| 4| 0| 3| 3| 3|
| 7| 9| 7| 7| 2| 7| 3| 8| 0| 5| 7| 3| 7| 9| 7| 7| 7| 1| 7| 7| 7| 5| 6| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | |
Incisor, Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 3 |
Embolus Bacterial | |
Inflammation, Suppurative | |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 4 3 3 4 3 4 4 4 3 3 4 3 3 4 2|
Angiectasis, Multiple | |
Cyst | |
Hemorrhage | 4 |
Hyperplasia | 3 2 3 3 3 |
Vacuolization Cytoplasmic | 3 1 4 3 3 1 3 3 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia | 3 2 2 3 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M M M + + M M M + M M + + + + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X X |
C-Cell, Hyperplasia | 4 3 3 1 2 1 4|
Follicular Cell, Cyst | |
Follicular Cell, Hyperplasia | 3 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + M + M M + M + + + + + + + + + M + + +|
Cyst | X |
Inflammation, Suppurative | 2 4 2 4 4 4 3 4 4|
__________________________________________________________________________|
Ovary | + M + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 7| 3| 3| 2| 3| 2| 7| 0| 0| 3| 8| 3| 6| 3| 3| 3| 4| 3| 3| 4| 0| 3| 3| 3|
| 7| 9| 7| 7| 2| 7| 3| 8| 0| 5| 7| 3| 7| 9| 7| 7| 7| 1| 7| 7| 7| 5| 6| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 4 3 |
Endometrium, Hyperplasia | 2 2 3 3 3 3|
Endometrium, Metaplasia, Squamous | |
Lumen, Dilatation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + M + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + M + + + + + + + + M + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + M + M M + M + M + + + M + M M + M M +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + M M + + + + + + + + M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + M M + + + + + + + + + M + + M A +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Galactocele | X X |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + M + + + + + + + + + + + + + + + + +|
Cranium, Necrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + M + + + + + + + + + + + + + +|
Compression | 3 3 |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Hemorrhage | 2 3 |
Inflammation, Granulomatous | 2 3 |
Leukocytosis | 4 |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | 1 2 2|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 7| 3| 3| 2| 3| 2| 7| 0| 0| 3| 8| 3| 6| 3| 3| 3| 4| 3| 3| 4| 0| 3| 3| 3|
| 7| 9| 7| 7| 2| 7| 3| 8| 0| 5| 7| 3| 7| 9| 7| 7| 7| 1| 7| 7| 7| 5| 6| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Fibrosis | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 3 3 3 3 3 2 2 3 4 2 3|
Alveolus, Inflammation, Suppurative | 3 1 2 2 3|
Artery, Mineralization | 3 4 4 3 4 4 3 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Suppurative | 4 4 2 2 |
Glands, Dilatation | 2 2 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 4 |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Glands, Dilatation | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Lacrimal Gland | + + + + |
Inflammation, Chronic | 1 1 |
Inflammation, Suppurative | 4 |
Karyomegaly | 1 1 2 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 3 2 2 3 2 1 3 3 3 1 1 1 1 2 1 2 2 1 3 1 2 1 1|
Pelvis, Dilatation | 3 |
Pelvis, Hyperplasia | 2 |
Pelvis, Mineralization | 3 1 2 3 3 1 1 |
Renal Tubule, Mineralization | 2 3 2 3 3 1 1 |
__________________________________________________________________________|
Urinary Bladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 2| 4| 7| |
DAY ON TEST | 7| 0| 2| 3| 3| 1| 6| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 0| 7| 2| |
| 9| 5| 1| 7| 7| 1| 7| 7| 7| 9| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 8| 7| 7| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +| 47 |
Acanthosis | 4 | 1 4.0|
Hyperkeratosis | 3 | 1 3.0|
Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + M + + M + + + M + + + + M + + + + A M + M M +| 34 |
Parasite Metazoan | 2| 3 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + A + + + + + + + + + +| 45 |
Inflammation, Suppurative | | 1 1.0|
Parasite Metazoan | X | 4 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + + + A + + + + + + + + + +| 46 |
Parasite Metazoan | | 2 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + + + + A + M + + + + + + A + + + + A + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + A + + + + A + + + + A| 41 |
Inflammation, Suppurative | 1 | 1 1.0|
Muscularis, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
Clear Cell Focus | | 1 1.0|
Eosinophilic Focus | X | 3 3.0|
Hematopoietic Cell Proliferation | 3 3 2 2 1 | 7 2.3|
Leukocytosis | | 1 4.0|
Necrosis | 4 | 2 3.5|
Vacuolization Cytoplasmic | 3 | 2 2.5|
Bile Duct, Cyst | X | 1 |
Bile Duct, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | + | 2 |
Necrosis | 4 | 1 4.0|
Ulcer | 4 | 1 4.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
Palate, Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
Karyomegaly | 2 1 1 | 4 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 2| 4| 7| |
DAY ON TEST | 7| 0| 2| 3| 3| 1| 6| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 0| 7| 2| |
| 9| 5| 1| 7| 7| 1| 7| 7| 7| 9| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 8| 7| 7| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2| 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Incisor, Developmental Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 | 7 2.1|
Embolus Bacterial | X | 1 |
Inflammation, Suppurative | 4 | 1 4.0|
Atrium, Thrombosis | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 4 3 4 3 4 2 4 4 2 3 2 2 3| 30 3.2|
Angiectasis, Multiple | 4 | 1 4.0|
Cyst | X | 1 |
Hemorrhage | | 1 4.0|
Hyperplasia | 4 3 3 3 2 3 3 2 3 3 3| 16 2.9|
Vacuolization Cytoplasmic | 3 3 4 3 | 13 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia | 1 3 3| 8 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M M M + + I M M M + M + M M + M M + M +| 26 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 1 4 2 | 4 2.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Ultimobranchial Cyst | X | 4 |
C-Cell, Hyperplasia | 3 2 4 | 10 2.7|
Follicular Cell, Cyst | X | 1 |
Follicular Cell, Hyperplasia | | 2 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 2| 4| 7| |
DAY ON TEST | 7| 0| 2| 3| 3| 1| 6| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 0| 7| 2| |
| 9| 5| 1| 7| 7| 1| 7| 7| 7| 9| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 8| 7| 7| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 43 |
Cyst | X X X X X | 6 |
Inflammation, Suppurative | 4 4 3 4 2 1 | 15 3.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X | 4 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 4 4 3 4 | 7 3.7|
Endometrium, Hyperplasia | 2 4 3 1 3 3 4 2 | 14 2.7|
Endometrium, Metaplasia, Squamous | 3 4 | 2 3.5|
Lumen, Dilatation | 4 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 4 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + M + + + + + + M + + + + M M + + + + + +| 34 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M + + M + + + + + + + + + M + +| 43 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 4 2 1 2 | 6 2.5|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + M + + + + M + + + M + + +| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Galactocele | | 2 |
Inflammation, Suppurative | 2 | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + M + + + + + + + + + + + + M + +| 48 |
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cranium, Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Compression | 1 | 3 2.3|
Hemorrhage | 4 | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 2| 4| 7| |
DAY ON TEST | 7| 0| 2| 3| 3| 1| 6| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 0| 7| 2| |
| 9| 5| 1| 7| 7| 1| 7| 7| 7| 9| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 8| 7| 7| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 3 1.3|
__________________________________________________________________________|____________|
Lung | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | | 1 2.0|
Hemorrhage | | 2 2.5|
Inflammation, Granulomatous | 3 | 3 2.7|
Leukocytosis | | 1 4.0|
Thrombosis | X | 2 |
Alveolar Epithelium, Hyperplasia | 2 | 4 1.8|
Alveolus, Fibrosis | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 2 2 2 3 3 3 2 3 | 21 2.7|
Alveolus, Inflammation, Suppurative | 3 2 2 2 3 1 1 2 | 13 2.1|
Artery, Mineralization | 3 3 3 3 4 3 3 3 3 3 3 3| 20 3.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 4 | 5 3.2|
Glands, Dilatation | 2 3 1 1 1 | 9 1.6|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 3 2 | 4 3.0|
Respiratory Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 | 2 1.5|
Glands, Dilatation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 5 |
Inflammation, Chronic | 2 | 3 1.3|
Inflammation, Suppurative | | 1 4.0|
Karyomegaly | 3 | 4 1.8|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 2 3 2 1 2 1 3 2 2 2 2 1 2 3 2 2 2 1 2 1 2 2 2| 48 1.9|
Pelvis, Dilatation | | 1 3.0|
Pelvis, Hyperplasia | 2 2 | 3 2.0|
Pelvis, Mineralization | 2 3 3 3 3 2 1 1| 15 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 2| 4| 7| |
DAY ON TEST | 7| 0| 2| 3| 3| 1| 6| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 0| 7| 2| |
| 9| 5| 1| 7| 7| 1| 7| 7| 7| 9| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 8| 7| 7| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Mineralization | 3 3 3 3 4 2 2 | 14 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 5| 5| 3| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 6| 3| 6| 5| 7| 1| 3| 4| 0| 3| 3| 3| 3| 3| 2| 3|
| 8| 8| 8| 8| 8| 8| 8| 4| 8| 9| 5| 4| 0| 9| 8| 8| 2| 8| 1| 8| 8| 8| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + A + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A M M + M M + M M + + + + M +|
Hemorrhage | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + A + + + + A +|
Inflammation, Suppurative | |
Necrosis | |
Parasite Metazoan | 2 |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + A + + + + A +|
Hyperplasia, Lymphoid | 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + M A M + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A A + + + + + A + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + A + + + + + +|
Angiectasis | 3 |
Basophilic Focus | 2|
Basophilic Focus, Multiple | X |
Clear Cell Focus | |
Developmental Malformation | X |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 3 2 3 |
Necrosis | 2 3 |
Bile Duct, Hyperplasia | 3|
Hepatocyte, Cytomegaly | 4 |
__________________________________________________________________________|
Mesentery | + |
Artery, Inflammation | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +|
Atrophy | 2 3 |
Acinus, Hyperplasia | 3 |
Artery, Inflammation | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + + + + + + + + A + + + + + +|
Karyomegaly | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + M + + + + + + + + A + + + + + +|
Acanthosis | 3 |
Perforation | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia | 2 |
Mineralization | 3 3 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 5| 5| 3| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 6| 3| 6| 5| 7| 1| 3| 4| 0| 3| 3| 3| 3| 3| 2| 3|
| 8| 8| 8| 8| 8| 8| 8| 4| 8| 9| 5| 4| 0| 9| 8| 8| 2| 8| 1| 8| 8| 8| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + A + + + + + +|
Cardiomyopathy | 2|
Inflammation, Suppurative | 4 |
Artery, Mineralization | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + A + + + + + +|
Angiectasis | 4 4 3 4 4 2 4 2 2 4 2 4 3 4 4 |
Hyperplasia | 4 3 3 3 2 2 |
Necrosis | |
Vacuolization Cytoplasmic | 4 2 2 2 4 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + A + + + + + +|
Hyperplasia | 3 3 2 2 |
Hyperplasia, Multiple | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M + + M M + + M + + M + + M + + M + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + I + + + + + +|
Pars Distalis, Cyst | X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + A + + + + + +|
Ultimobranchial Cyst | X X |
C-Cell, Hyperplasia | 1 4 3 3 3 2 |
Follicular Cell, Cyst | X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + M + M M + + M + + + + +|
Cyst | X 2 X X X X X |
Cyst, Multiple | |
Inflammation, Suppurative | 3 4 4 4 2 3|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + A + + + + + +|
Cyst | X X X X X X |
Inflammation, Suppurative | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Endometrium, Hyperplasia | 3 2 2 2 2 2 2 3 2 2|
Endometrium, Metaplasia, Squamous | 4 |
Lumen, Dilatation | |
Lumen, Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 5| 5| 3| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 6| 3| 6| 5| 7| 1| 3| 4| 0| 3| 3| 3| 3| 3| 2| 3|
| 8| 8| 8| 8| 8| 8| 8| 4| 8| 9| 5| 4| 0| 9| 8| 8| 2| 8| 1| 8| 8| 8| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Wall, Necrosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + M + + + + + M + + + + A + + + + A +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Hemorrhage | 3 |
Renal, Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + M M + M + + M + + + M + + + + +|
Hemorrhage | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + M A + + + + + +|
Hemorrhage | 3 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + M + + A + + + + + +|
Cyst | X |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X |
Inflammation, Suppurative | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + M + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 3 |
Hemorrhage | 4 2 |
Ventricle, Dilatation | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + A + + + + + + A + + + + + +|
Foreign Body | 3 |
Inflammation, Suppurative | 3 3 2 2|
Epithelium, Hyperplasia | 2|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 |
Inflammation, Granulomatous | 1 4 3 3 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 5| 5| 3| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 6| 3| 6| 5| 7| 1| 3| 4| 0| 3| 3| 3| 3| 3| 2| 3|
| 8| 8| 8| 8| 8| 8| 8| 4| 8| 9| 5| 4| 0| 9| 8| 8| 2| 8| 1| 8| 8| 8| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 2 2 1 2 2 2 1 1 2 2|
Alveolus, Fibrosis | 3 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 3 3 3 2 3 1 3 3 3 3 3 3 2 3 2 4 3|
Alveolus, Inflammation, Suppurative | 2 4 2|
Artery, Mineralization | 3 3 3 3 3 4 3 3 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + A + + + + + +|
Inflammation, Suppurative | 2 2 2 2 |
Glands, Dilatation | 2 1 2 2 2 2 3 2 1 3 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
Olfactory Epithelium, Degeneration | 2 1 1 1 1 1 1 2 2 2 2 2 1 1 2 1 2 3 1 3 2 3 2|
Olfactory Epithelium, Metaplasia | 2 1 |
Olfactory Epithelium, Metaplasia, | |
Squamous | 1 1 2 2 2 2 |
Respiratory Epithelium, Hyperplasia | 1 1 1 2 1 2 1 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 1 1 1 1 1 1 1 2 1 2 1 1 2 1 1 2 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + A + + + + + +|
Inflammation, Suppurative | 2 |
Mineralization | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract, Multiple | 3 |
__________________________________________________________________________|
Lacrimal Gland | |
Hyperplasia | |
Inflammation, Chronic | |
Karyomegaly | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + A + + + + + +|
Cyst | X |
Nephropathy, Chronic | 1 2 2 2 2 1 1 2 2 3 3 4 1 2 2 1 1 2 1 2 2 2 2|
Pelvis, Hyperplasia | 3 2 |
Pelvis, Mineralization | 2 2 4 2 3 |
Renal Tubule, Degeneration | 4 |
Renal Tubule, Mineralization | 2 2 3 4 2 2 2 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia | 3 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3| |
| 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + A + A + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + M + M + M + + + + M + M + M + + + M +| 35 |
Hemorrhage | 3 | 1 3.0|
Parasite Metazoan | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + A + + + + + + + + + + + + + + + +| 45 |
Inflammation, Suppurative | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
Parasite Metazoan | 3 | 2 2.5|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + A + + + + + + + + + + + + + + + +| 45 |
Hyperplasia, Lymphoid | | 1 2.0|
Parasite Metazoan | 3 2 | 3 2.5|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A + A + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + A + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + A + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + A + A + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 3 2 | 3 2.7|
Basophilic Focus | 3 | 2 2.5|
Basophilic Focus, Multiple | | 1 |
Clear Cell Focus | 2 | 1 2.0|
Developmental Malformation | | 1 |
Eosinophilic Focus | | 1 |
Hematopoietic Cell Proliferation | 3 | 4 2.8|
Necrosis | 3 | 3 2.7|
Bile Duct, Hyperplasia | 2 1 | 3 2.0|
Hepatocyte, Cytomegaly | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 3 | 3 2.7|
Acinus, Hyperplasia | 3 | 2 3.0|
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + M +| 47 |
Karyomegaly | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
Acanthosis | 4 3| 3 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3| |
| 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Perforation | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 2.0|
Mineralization | | 2 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 4 3 2 | 4 2.8|
Inflammation, Suppurative | | 1 4.0|
Artery, Mineralization | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 4 3 3 2 3 4 4 4 2 4 3 4 4 4 3 4 3 4 2 2| 36 3.3|
Hyperplasia | 3 4 2 2 4| 11 2.9|
Necrosis | 3 | 1 3.0|
Vacuolization Cytoplasmic | 3 4 4 3 3 | 11 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 3 2 3 2 1| 10 2.2|
Hyperplasia, Multiple | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + + M + + M + + M + M + + + + + + + M M M| 32 |
__________________________________________________________________________|____________|
Pituitary Gland | I + + + + + A + + + M + + M + + + + + + + + + + +| 45 |
Pars Distalis, Cyst | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + I + A + + + + + + + + + + + + + + + +| 47 |
Ultimobranchial Cyst | X X X X X X X | 9 |
C-Cell, Hyperplasia | 3 1 2 4 4 3 | 12 2.8|
Follicular Cell, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 45 |
Cyst | X X X X X | 12 2.0|
Cyst, Multiple | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3| |
| 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 4 4 4 4 4 4 4 | 13 3.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Cyst | X X X X | 10 |
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 2.0|
Endometrium, Hyperplasia | 2 2 2 3 2 3 2 2 3 4 3 1| 22 2.3|
Endometrium, Metaplasia, Squamous | 2 2 4 4| 5 3.2|
Lumen, Dilatation | 4 4 4 4| 4 4.0|
Lumen, Hemorrhage | 4 3 | 2 3.5|
Wall, Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + A + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesenteric, Hemorrhage | | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + M M + + + + M + + + + + M + + + + M + +| 39 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + M +| 45 |
Hemorrhage | | 2 3.5|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 4 | 5 3.4|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | X X X | 4 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | | 1 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrous Osteodystrophy | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3| |
| 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 4 3 | 5 3.4|
Hemorrhage | | 2 3.0|
Ventricle, Dilatation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Foreign Body | | 1 3.0|
Inflammation, Suppurative | 1 | 5 2.2|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 4.0|
Inflammation, Granulomatous | 2 2 2 | 7 2.4|
Alveolar Epithelium, Hyperplasia | 2 2 2 2 | 14 1.8|
Alveolus, Fibrosis | | 2 2.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 3 3 3 2 3 2 3 3 3 1 3 3 3 3 3 3 1 1 3 3 3 2| 41 2.6|
Alveolus, Inflammation, Suppurative | 2 1 | 5 2.2|
Artery, Mineralization | 3 3 3 3 3 3 3 | 16 3.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 2 2 3 | 7 2.1|
Glands, Dilatation | 2 2 2 2 3 3 3 2 1 3 2 2 3 3 2 2| 29 2.2|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 3.0|
Olfactory Epithelium, Degeneration | 2 1 1 1 1 1 1 2 1 2 1 1 1 1 2 1 2 2 2 1 2 2 2| 46 1.6|
Olfactory Epithelium, Metaplasia | 1 2 | 4 1.5|
Olfactory Epithelium, Metaplasia, | | |
Squamous | 1 1 1 | 9 1.4|
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 | 18 1.1|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1| 37 1.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 2.0|
Mineralization | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3| |
| 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cataract, Multiple | | 1 3.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
Karyomegaly | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Cyst | | 1 |
Nephropathy, Chronic | 2 1 2 1 1 2 2 2 2 1 2 2 2 1 2 2 2 1 1 | 42 1.8|
Pelvis, Hyperplasia | 3 | 3 2.7|
Pelvis, Mineralization | 2 3 3 2 3 3 1 1 2 3| 15 2.4|
Renal Tubule, Degeneration | | 1 4.0|
Renal Tubule, Mineralization | 3 2 2 2 2 2 2 | 18 2.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 5| 7| 7| 6| 0| 5| 7| 7| 7| 7| 4| 6| 7| 7| 2| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 7| 0| 3| 5| 3| 7| 3| 3| 3| 3| 0| 6| 3| 1| 2| 3| 2| 2| 3| 3| 3|
| 1| 9| 9| 9| 0| 5| 9| 2| 1| 8| 9| 9| 9| 9| 9| 8| 9| 5| 0| 9| 4| 4| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + + + + A + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + + + M + + + M M + + + + M + + + M + + + + + +|
Granuloma | 3 |
Inflammation | 4 |
Parasite Metazoan | 2 3 |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + A + + + + + + + + + A + + + + + +|
Parasite Metazoan | 2 3 |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + A A + + + + + + + + A + + + + M +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + A A + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + A A + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + A A + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + I + A A + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Clear Cell Focus | 2 |
Developmental Malformation | |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Suppurative | 2 |
Leukocytosis | |
Necrosis | 4 |
Bile Duct, Cyst | X |
Bile Duct, Hyperplasia | 1 2 |
__________________________________________________________________________|
Mesentery | + + + |
Artery, Inflammation | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic | 2 |
Artery, Inflammation | 4 4 4|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Karyomegaly | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + I + + + + + + + + + + + + +|
Acanthosis | 4 3 |
Hyperkeratosis | 4 |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + A + + + + + + + + A + + + + + +|
Erosion | 4 |
Inflammation, Suppurative | 3 |
Mineralization | 4 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 5| 7| 7| 6| 0| 5| 7| 7| 7| 7| 4| 6| 7| 7| 2| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 7| 0| 3| 5| 3| 7| 3| 3| 3| 3| 0| 6| 3| 1| 2| 3| 2| 2| 3| 3| 3|
| 1| 9| 9| 9| 0| 5| 9| 2| 1| 8| 9| 9| 9| 9| 9| 8| 9| 5| 0| 9| 4| 4| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Suppurative | |
Artery, Mineralization | 4 |
Myocardium, Mineralization | 4 |
Myocardium, Necrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 2 3 3 3 3 4 3 4 |
Atrophy | 4 |
Hemorrhage | 4 |
Hyperplasia | 3 3 3 3 3 4 4 |
Vacuolization Cytoplasmic | 2 4 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + M M M + + + + + M + + + M + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Pars Distalis, Hyperplasia | 2 3 3 |
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + A + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X |
C-Cell, Hyperplasia | 2 1 3 3 3|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + M + + + + + +|
Cyst | X X X X X X X X|
Inflammation, Suppurative | 4 4 3 3 3 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 4 |
Thrombosis | |
Artery, Inflammation | 4 |
Endometrium, Hyperplasia | 2 2 4 3 |
Endometrium, Metaplasia, Squamous | 4 3 2 |
Lumen, Dilatation | 4 4 3|
Lumen, Hemorrhage | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 5| 7| 7| 6| 0| 5| 7| 7| 7| 7| 4| 6| 7| 7| 2| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 7| 0| 3| 5| 3| 7| 3| 3| 3| 3| 0| 6| 3| 1| 2| 3| 2| 2| 3| 3| 3|
| 1| 9| 9| 9| 0| 5| 9| 2| 1| 8| 9| 9| 9| 9| 9| 8| 9| 5| 0| 9| 4| 4| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + + + M + + + + + M + + + + +|
Fibrosis | 3 |
Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + M + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hematopoietic Cell Proliferation | 3 2 3 |
Artery, Inflammation | 4 |
__________________________________________________________________________|
Thymus | + + M + + M + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 4 |
Osteopetrosis | 4 |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Gliosis | 2 |
__________________________________________________________________________|
Spinal Cord | + |
White Matter, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 |
Inflammation, Granulomatous | 3 4 2 |
Alveolar Epithelium, Hyperplasia | 1 2 1 2 2 2 1 |
Alveolus, Fibrosis | 1 1 |
Alveolus, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 5| 7| 7| 6| 0| 5| 7| 7| 7| 7| 4| 6| 7| 7| 2| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 7| 0| 3| 5| 3| 7| 3| 3| 3| 3| 0| 6| 3| 1| 2| 3| 2| 2| 3| 3| 3|
| 1| 9| 9| 9| 0| 5| 9| 2| 1| 8| 9| 9| 9| 9| 9| 8| 9| 5| 0| 9| 4| 4| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Histiocyte | 3 3 2 3 3 2 2 3 3 3 3 3 |
Alveolus, Inflammation, Suppurative | 2 |
Artery, Inflammation | 4 |
Artery, Mineralization | 3 4 3 3 4 3 3 3 3 3 3|
Bronchiole, Hyperplasia | 2 |
Pleura, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + A A + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 2 2 2 2 3 |
Glands, Dilatation | 2 3 3 2 2 2 2 2 2 2 2 2 2 2 3 2|
Olfactory Epithelium, Degeneration | 2 3 2 3 3 3 3 4 3 2 2 2 3 2 2 2 3 3 4 3 2 4 2|
Olfactory Epithelium, Metaplasia | 2 1 1 |
Olfactory Epithelium, Metaplasia, | |
Squamous | 2 2 1 1 1 2 2 3 2 2 1 2 3 2 1 |
Respiratory Epithelium, Dysplasia | 4 |
Respiratory Epithelium, Hyperplasia | 3 1 4 2 3 2 2 3 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 2 1 1 1 1 4 2 3 2 2 3 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Lacrimal Gland | + |
Inflammation, Chronic | 2 |
Karyomegaly | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X|
Nephropathy, Chronic | 2 1 2 3 2 3 2 1 2 1 3 3 1 1 1 1 1 1 2 2 2 4 1 3 2|
Pelvis, Hyperplasia | 2 1 |
Pelvis, Mineralization | 2 3 3 2 4 2 3 2 |
Renal Tubule, Mineralization | 2 3 2 2 2 3 3 3 2 |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + A + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7| |
DAY ON TEST | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3| |
| 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + M + + + M + + + + M + + + + + M + + + M M +| 38 |
Granuloma | | 1 3.0|
Inflammation | | 1 4.0|
Parasite Metazoan | 1 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +| 46 |
Parasite Metazoan | 3 X 3 | 5 2.8|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + A + +| 43 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + A + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Angiectasis | 3 4 | 3 2.7|
Clear Cell Focus | 2 | 2 2.0|
Developmental Malformation | X | 1 |
Hematopoietic Cell Proliferation | 2 2 | 3 2.0|
Inflammation, Suppurative | | 1 2.0|
Leukocytosis | 2 | 1 2.0|
Necrosis | 4 4 | 3 4.0|
Bile Duct, Cyst | | 1 |
Bile Duct, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Atrophy | 2 2 | 2 2.0|
Inflammation, Chronic | | 1 2.0|
Artery, Inflammation | 4 3 | 5 3.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + A + +| 48 |
Inflammation, Chronic | 2 | 1 2.0|
Karyomegaly | 1 | 2 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + I| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + I + + + + + + + M + + + + + + M| 46 |
Acanthosis | | 2 3.5|
Hyperkeratosis | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + I| 44 |
Erosion | | 1 4.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7| |
DAY ON TEST | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3| |
| 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 2 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 4 | 5 2.6|
Inflammation, Suppurative | 2 | 1 2.0|
Artery, Mineralization | | 1 4.0|
Myocardium, Mineralization | | 1 4.0|
Myocardium, Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Angiectasis | 3 4 2 4 2 2 3 3 3 4 2 4| 22 3.0|
Atrophy | | 1 4.0|
Hemorrhage | | 1 4.0|
Hyperplasia | 3 2 3 2 3 | 12 3.0|
Vacuolization Cytoplasmic | 2 3 3 4 2 2 | 9 2.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + M + + + + M + + + + + + + A + +| 47 |
Hyperplasia | 2 3 | 4 2.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + + + + + M + M M M + + M + + M M + +| 33 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia | 2 4 | 5 2.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 47 |
Ultimobranchial Cyst | X X | 4 |
C-Cell, Hyperplasia | 3 3 3 2 3 | 10 2.6|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + M + + + A M +| 43 |
Cyst | X X X X X X | 14 |
Inflammation, Suppurative | 3 3 3 2 4 2 4 4| 15 3.2|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Cyst | X X | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7| |
DAY ON TEST | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3| |
| 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Capsule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 | 3 3.3|
Thrombosis | X | 1 |
Artery, Inflammation | | 1 4.0|
Endometrium, Hyperplasia | 4 4 4 4 4 2 2 3| 12 3.2|
Endometrium, Metaplasia, Squamous | 2 4 4 | 6 3.2|
Lumen, Dilatation | | 3 3.7|
Lumen, Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + M M + + + + M M +| 43 |
Fibrosis | | 1 3.0|
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + M + + + + + + + + + M + + + A + +| 44 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Cyst | | 1 |
Hematopoietic Cell Proliferation | 2 2 2 3 3 | 8 2.5|
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | M M + + + + + + + + + + + + + + + + + M + + A + +| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 3 3 | 2 3.0|
Cyst Epithelial Inclusion | | 1 |
Hyperkeratosis | 4 | 1 4.0|
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 4.0|
Osteopetrosis | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7| |
DAY ON TEST | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3| |
| 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 3 | 2 2.5|
Gliosis | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
White Matter, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Foreign Body | | 1 3.0|
Inflammation, Granulomatous | | 3 3.0|
Alveolar Epithelium, Hyperplasia | 1 3 2 2 2 2 2| 14 1.8|
Alveolus, Fibrosis | | 2 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 3 2 3 4 4 2 3 3 3 3 3 3 3 2 3 2 1 3| 31 2.8|
Alveolus, Inflammation, Suppurative | 1 2 1 | 4 1.5|
Artery, Inflammation | | 1 4.0|
Artery, Mineralization | 3 3 3 3 | 15 3.1|
Bronchiole, Hyperplasia | | 1 2.0|
Pleura, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
Inflammation, Suppurative | 2 4 2 2 | 11 2.2|
Glands, Dilatation | 1 2 2 2 3 2 2 3 2 1 2 3 3 3 2 1 3 3 2 2 2 2 2| 39 2.2|
Olfactory Epithelium, Degeneration | 3 2 3 3 4 3 3 3 2 3 3 3 3 3 3 2 2 3 4 3 4 3 3 2| 47 2.8|
Olfactory Epithelium, Metaplasia | 2 2 2 | 6 1.7|
Olfactory Epithelium, Metaplasia, | | |
Squamous | 1 2 2 1 2 1 2 2 2 2 1 2 3 1 2 2 | 31 1.8|
Respiratory Epithelium, Dysplasia | | 1 4.0|
Respiratory Epithelium, Hyperplasia | 1 2 1 1 3 3 2 1 2 3 2 2 3 | 22 2.1|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 1 3 2 2 2 3 1 1 2 2 2 2 2 1 1 3 3 3 1 2 3 2| 38 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 2 |
Inflammation, Chronic | 2 | 2 2.0|
Karyomegaly | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7| |
DAY ON TEST | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3| |
| 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Cyst | X| 3 |
Nephropathy, Chronic | 2 2 1 1 3 2 1 2 1 1 1 1 2 1 1 2 1 3 2 1 1| 46 1.7|
Pelvis, Hyperplasia | | 2 1.5|
Pelvis, Mineralization | 2 2 2 2 2 2 2| 15 2.3|
Renal Tubule, Mineralization | 2 1 | 11 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|
DAY ON TEST | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|
| 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + + + + + + A A + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + + + + + M M M + + M M + A M M M M + + + + M +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + A A + M + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + A A A I A + + + + + +|
Parasite Metazoan | 2 X |
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + A + + A A A A A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + A + + A A A A M + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A A + + + + A A A + + A + + A A A A A + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + A A A + + A + + A A A A A + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + A + + + + + +|
Angiectasis | 1 |
Basophilic Focus | 1 |
Clear Cell Focus | |
Developmental Malformation | |
Hematopoietic Cell Proliferation | |
Inflammation, Granulomatous | 4 |
Bile Duct, Fibrosis | 2 |
__________________________________________________________________________|
Mesentery | + |
Inflammation | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + A + + + + + +|
Atrophy | 2 |
Acinus, Hyperplasia | 2 |
Artery, Inflammation | 4 4 4 3 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 2 2 2 3 3 2 3 1|
Inflammation, Suppurative | |
Karyomegaly | 2 2 2 2 3 2 2 3 2 2 2 2 2 3 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + A + A + + + + + +|
Artery, Inflammation | 4 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + A + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + A + + + + + +|
Mineralization | 4 |
Artery, Inflammation | 4 3 |
__________________________________________________________________________|
Tongue | + + |
Hyperplasia, Squamous | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 4 3 3 2 1 3 2 2|
Aortic Valve, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|
DAY ON TEST | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|
| 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Artery, Inflammation | 3 |
Artery, Mineralization | 4 3 3|
Atrium, Mineralization | |
Atrium, Thrombosis | X X X|
Ventricle, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + A + + A + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + A + + A + + + + + +|
Hemorrhage | |
Hyperplasia | 1 1 2 4 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + M + + + + + A + + A + + + + + +|
Hyperplasia | 2 1 1 2 |
Hyperplasia, Multiple | 2 |
Mineralization | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + A + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + + + + + + M + + + M + + M + + + + + + + M M|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + I + + + + + + + + + A + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A A + A + + + A + +|
Inflammation, Chronic | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | M + M M + + + M + + + + + + + M + + + M + + + + +|
Artery, Inflammation | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Inflammation, Suppurative | 4 4 4 1 3 3 4 4 3 4 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + A + + + + + +|
Inflammation, Suppurative | 4 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + A + + + + + +|
Inflammation, Suppurative | 4 2 |
Artery, Inflammation | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Artery, Inflammation | 4 4 4 4 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|
DAY ON TEST | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|
| 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Seminiferous Tubule, Atrophy | 4 4 2 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + A A + + A + + + + + +|
__________________________________________________________________________|
Lymph Node | M + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Lymphoid | 4 |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M + + + M M + + + + + M M + A + + + + M +|
Hemorrhage | 3 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + M + + + + M + + + + + + + + + + + M +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + M + + +|
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M M + + + + M + + + + A + M M M M + M M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + A + + + + + + + + + +|
Giant Cell | |
Granuloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Laryngeal, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Demyelination | 1 |
Hemorrhage | 3 3 |
Thrombosis | |
Ventricle, Dilatation | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | A A + + + + + A + + + A + + A A A + A + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Lung | + A + + + + + + + + + + + + A A A + A + + + + + +|
Foreign Body | 3 |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|
DAY ON TEST | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|
| 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Granulomatous | 3 2 |
Alveolar Epithelium, Hyperplasia | 2 1 |
Alveolus, Edema | 2 |
Alveolus, Fibrosis | 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 3 2 |
Alveolus, Inflammation, Suppurative | 3 2 2 1 1 2|
Artery, Inflammation | 3 2 3 3 |
Artery, Mineralization | 3 2 3 2 3 3 3 2 |
Bronchiole, Inflammation, Suppurative| 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + A + + + A + + + + + +|
Foreign Body | 2 |
Inflammation, Suppurative | 1 2 |
Inflammation, Membranous | 2 2 1 |
Glands, Dilatation | 3 4 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 4 2 |
Respiratory Epithelium, Hyperplasia | 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 2 |
__________________________________________________________________________|
Trachea | A A + + + + + A + + + A + + A A A + A + + + A + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | 3 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Lacrimal Gland | + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 3 3 2 3 2 3 3 3 3 3|
Karyomegaly | 1 3 3 3 3 3 3 3 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hemorrhage | |
Inflammation, Suppurative | 3 |
Nephropathy, Chronic | 2 4 4 3 3 4 4 3 4 3 3 3 3 4 4 3 3 4 4 4 4 3 3 4|
Artery, Mineralization | |
Pelvis, Hyperplasia | 3 3 |
Pelvis, Mineralization | 1 |
Renal Tubule, Mineralization | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + A + A + + + + + +|
Calculus Gross Observation | X X |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|
DAY ON TEST | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|
| 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Calculus Micro Observation Only | X X |
Hyperplasia | 4 |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5| |
DAY ON TEST | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4| |
| 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + A A A + A + + A + +| 41 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + M A + + A + + + + M M M M A A M + A M + M M M| 23 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + A A A + A + + A A +| 39 |
Parasite Metazoan | X 2| 4 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A A A + + + + A + +| 40 |
Parasite Metazoan | X X | 4 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + A + + A + + + + A + + + A + A + A + + A A +| 35 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + A + + + + A + + + A A A + A + + A A +| 33 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + A + + A + A A A + A A A + A A + A A A| 24 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + A + + A + A A A + A A A + A A + A A A| 24 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 1.0|
Basophilic Focus | | 1 1.0|
Clear Cell Focus | X | 1 |
Developmental Malformation | X | 1 |
Hematopoietic Cell Proliferation | 3| 1 3.0|
Inflammation, Granulomatous | 2 2 | 3 2.7|
Bile Duct, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 2 | 2 2.0|
Acinus, Hyperplasia | | 1 2.0|
Artery, Inflammation | 4 | 6 3.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 | 12 1.9|
Inflammation, Suppurative | 1 3 | 2 2.0|
Karyomegaly | 2 2 2 2 1 1 | 21 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + + + + + + I + + M + + + + + +| 45 |
Inflammation, Suppurative | 2| 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mineralization | 3 4 3| 4 3.5|
Artery, Inflammation | | 2 3.5|
__________________________________________________________________________|____________|
Tongue | | 2 |
Hyperplasia, Squamous | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5| |
DAY ON TEST | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4| |
| 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 3 | 12 2.3|
Aortic Valve, Mineralization | 3 3 | 2 3.0|
Artery, Inflammation | 3| 2 3.0|
Artery, Mineralization | 4 3 3 4 | 7 3.4|
Atrium, Mineralization | 3 | 1 3.0|
Atrium, Thrombosis | X X X X X| 8 |
Ventricle, Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | 4| 1 4.0|
Hyperplasia | 1 1 2 3 | 8 1.9|
Vacuolization Cytoplasmic | 4 2 4 2 3 2 3 3 2 | 10 2.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 3 3 2 2 2 3 | 10 2.1|
Hyperplasia, Multiple | | 1 2.0|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + + + + + + + + M + + M + + + M M + M +| 36 |
Hyperplasia | 3 2| 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + I + + + + +| 47 |
Pars Distalis, Cyst | X X| 2 |
Pars Distalis, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + A + + + + A + A + + + + +| 43 |
Inflammation, Chronic | 2 | 1 2.0|
Ultimobranchial Cyst | X X X X| 4 |
C-Cell, Hyperplasia | 2 2 2 3 1 | 10 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + M + + + + + + + + +| 43 |
Artery, Inflammation | 4| 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5| |
DAY ON TEST | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4| |
| 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | X X X X | 7 |
Inflammation, Suppurative | 3 4 4 2 3 2 4 3 2| 22 3.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 | 3 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2| 3 2.7|
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Mineralization | 2 | 1 2.0|
Artery, Inflammation | 4 3 4 3 4 4| 10 3.8|
Seminiferous Tubule, Atrophy | 4 4| 7 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | | 1 4.0|
Renal, Hemorrhage | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + + + + + + + + + + + + + M + + + +| 40 |
Hemorrhage | 3 3 3| 5 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + M +| 44 |
Hemorrhage | 3 | 2 2.5|
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + M + +| 46 |
Artery, Inflammation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M M + + M + + + + M M + M M + + M M + M + + M| 27 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Giant Cell | 4 | 1 4.0|
Granuloma | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Laryngeal, Degeneration | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5| |
DAY ON TEST | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4| |
| 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X | 1 |
Demyelination | | 1 1.0|
Hemorrhage | 2 3 | 4 2.8|
Thrombosis | X | 1 |
Ventricle, Dilatation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + I + A + + + + A + +| 39 |
Inflammation, Chronic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lung | + + + A + + + + + + + + + + + A + A + + + + + + +| 42 |
Foreign Body | | 1 3.0|
Hemorrhage | 2 3 3 4 4 3| 7 3.0|
Inflammation, Granulomatous | 3 3 3 | 5 2.8|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
Alveolus, Edema | | 1 2.0|
Alveolus, Fibrosis | | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 2 3| 7 2.4|
Alveolus, Inflammation, Suppurative | | 6 1.8|
Artery, Inflammation | 4 1 2 | 7 2.6|
Artery, Mineralization | 3 4 2 2 3 3 2 3 3 3 | 18 2.7|
Bronchiole, Inflammation, Suppurative| | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + A + + + + + + + + + + + A + A + + + + A + +| 44 |
Foreign Body | | 1 2.0|
Inflammation, Suppurative | 1 3 1 1 1 2 2| 9 1.6|
Inflammation, Membranous | | 3 1.7|
Glands, Dilatation | 1 2 1 | 8 2.1|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 4 2 3 | 7 2.7|
Respiratory Epithelium, Hyperplasia | 1 1| 4 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1| 4 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + A + +| 40 |
Inflammation, Suppurative | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5| |
DAY ON TEST | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4| |
| 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + A | 3 |
Hyperplasia | 4 | 2 3.5|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + + + + + + | 19 |
Inflammation, Chronic | 3 3 3 3 3 2 | 19 2.6|
Karyomegaly | 4 3 4 4 3 3 | 19 3.1|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Suppurative | | 1 3.0|
Nephropathy, Chronic | 4 4 2 4 4 4 3 3 4 4 4 3 3 4 2 4 4 3 4 3 4 4 4 3 4| 49 3.5|
Artery, Mineralization | 4 | 1 4.0|
Pelvis, Hyperplasia | | 2 3.0|
Pelvis, Mineralization | 2 2 | 3 1.7|
Renal Tubule, Mineralization | 4 | 2 3.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +| 46 |
Calculus Gross Observation | | 2 |
Calculus Micro Observation Only | X | 3 |
Hyperplasia | 3 | 2 3.5|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|
DAY ON TEST | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|
| 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + + A + + + + + + A + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M M + + A + + + M M + M + M + + + M + A + + M M A|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + A + A + A + + + + + + + + + + +|
Parasite Metazoan | 2 3 3|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + A + + + + + + A + A + + + + + + + + + + +|
Parasite Metazoan | X |
Artery, Inflammation | 4 |
__________________________________________________________________________|
Intestine Small | A A + + A + + + A + + A + A + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + + + + + + + + A + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A A A + A + + + A M + A + A + + + + + A + + A + A|
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + A + + + A M + A + A + + + + + A + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | |
Clear Cell Focus | 2 3 2 X|
Hematopoietic Cell Proliferation | 3 |
Inflammation, Suppurative | 3 |
Necrosis | 3 3 |
Bile Duct, Fibrosis | 3 |
Bile Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 |
Acinus, Hyperplasia | 3|
Artery, Inflammation | 4 4 3 3 4|
__________________________________________________________________________|
Salivary Glands | + A + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic | 2 2 1 |
Inflammation, Granulomatous | 4 |
Karyomegaly | 1 3 2 2 3 2 2 1 2 2 1 2 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation | 3 |
__________________________________________________________________________|
Stomach, Forestomach | M + + M + + + + + + + + + + + + + + + + + + M + +|
Acanthosis | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Mineralization | |
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|
DAY ON TEST | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|
| 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 2 2 2 2 2|
Artery, Inflammation | |
Artery, Mineralization | |
Atrium, Thrombosis | X X |
Endocardium, Fibrosis | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia | 3 2 3 2 3 3 |
Inflammation, Chronic | |
Mineralization | |
Necrosis | |
Vacuolization Cytoplasmic | 4 3 2 3 3 3 2 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 4 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | M + + M M M + + + + M + + M + + + + + + + M M M +|
Hyperplasia | |
Hyperplasia, Multiple | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 2|
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + I + + + + + M + + + + + M + + M M + +|
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Inflammation, Suppurative | 3 4 4 3 4 3 2 4 4 4 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|
DAY ON TEST | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|
| 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Mineralization | 3|
Artery, Inflammation | 4 4 4 4 4 4 4 |
Seminiferous Tubule, Atrophy | 3 3 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + M + + + + + + + + + + M +|
Fibrosis | |
Mediastinal, Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + M M M M M + M + + M M + M + M + + M +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + M M +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | |
Infarct | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + + + + + + + + + + + + M + + + + M + + + +|
__________________________________________________________________________|
Skin | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Gliosis | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Hemorrhage | 4 3 |
Inflammation, Granulomatous | 4 |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia | 3 1 |
Alveolus, Edema | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|
DAY ON TEST | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|
| 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Fibrosis | 4 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 3 4 4 3 3|
Alveolus, Inflammation, Suppurative | 3 2 3 2 |
Artery, Inflammation | 4 4 3 4 4 4 4 3 4|
Artery, Mineralization | 3 4 4 4 3 3 4 3 3 3 2 3 4 |
Bronchiole, Infiltration Cellular, | |
Histiocyte | 4|
Bronchiole, Inflammation, Suppurative| |
__________________________________________________________________________|
Nose | + + A + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Suppurative | 2 3 2 3 1 2 2 2 2 2 2 2 2 3 3 2 2 |
Inflammation, Membranous | 2 3 |
Glands, Dilatation | 3 2 3 3 2 3 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Olfactory Epithelium, Degeneration | 3 3 3 2 1 2 3 3 1 1 2 2 2 1 2 4 2 2 3 3 3 3 1|
Olfactory Epithelium, Metaplasia | 2 1 2 2 |
Olfactory Epithelium, Metaplasia, | |
Squamous | 2 2 1 3 1 3 3 3 |
Respiratory Epithelium, Hyperplasia | 1 3 2 2 1 3 2 2 2 1 1 2 2 2 2 2 2 1 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 3 2 2 2 1 3 1 1 1 2 2 2 1 2 2 2 1 2 1 1 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Lacrimal Gland | + + + + + + + + + + + + |
Inflammation, Chronic | 3 3 2 3 3 3 3 3 3 2 3 3 |
Inflammation, Suppurative | 3 |
Karyomegaly | 3 3 3 3 3 2 3 3 3 3 3 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy, Chronic | 3 4 4 3 4 3 4 4 4 4 3 3 4 3 4 4 4 4 4 4 3 3 2 3 4|
Pelvis, Hemorrhage | 2 |
Pelvis, Hyperplasia | 2 3 |
Pelvis, Inflammation, Suppurative | 3 |
Pelvis, Mineralization | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|
DAY ON TEST | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|
| 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 |
Artery, Inflammation | 4 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4| |
DAY ON TEST | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1| |
| 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + A + + + + + + + + + + + + + + + + + + M +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + A + A + + + + + + + + + + + + + + + + + A + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M M M + M M M M + + + A + M M A M + M + + M A M M| 21 |
Parasite Metazoan | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + M A + A + A + + A + A + + + + + + + + + A A + +| 38 |
Parasite Metazoan | | 3 2.7|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + A + + + + + + + + + + + I + + + + + A + +| 42 |
Parasite Metazoan | 3 | 2 3.0|
Artery, Inflammation | 3 | 2 3.5|
__________________________________________________________________________|____________|
Intestine Small | + A A + A A A A + + + + + + + A + + + + + A A + +| 34 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A A + A A A A + + + + + + + A + + + + + A A + +| 37 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A A + A A A A + M + A + + + A A + + + + A A + +| 27 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A A + A A A A + A + A + + + A A + + + + A A + A| 27 |
__________________________________________________________________________|____________|
Liver | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Basophilic Focus | 2 | 1 2.0|
Clear Cell Focus | | 4 2.3|
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Inflammation, Suppurative | | 1 3.0|
Necrosis | 4 | 3 3.3|
Bile Duct, Fibrosis | 2 | 2 2.5|
Bile Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + A + A + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 1 3 2 | 6 2.2|
Inflammation, Chronic | 4 | 1 4.0|
Inflammation, Suppurative | | 1 3.0|
Acinus, Hyperplasia | | 1 3.0|
Artery, Inflammation | 4 4 | 7 3.7|
__________________________________________________________________________|____________|
Salivary Glands | + + A + A + + + + + + + + + + + + + + + + + + + M| 46 |
Cyst | | 1 |
Inflammation, Chronic | 1 2 2 | 6 1.7|
Inflammation, Granulomatous | | 1 4.0|
Karyomegaly | 2 2 2 2 2 3 1 1 2 | 23 1.9|
__________________________________________________________________________|____________|
Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Artery, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + A + + + + I + + + + + + + + + M + + + + +| 43 |
Acanthosis | 3 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + A + + + + + + + +| 48 |
Developmental Malformation | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4| |
DAY ON TEST | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1| |
| 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | 4 | 1 4.0|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 2 3 3 3 3| 12 2.4|
Artery, Inflammation | 4 | 1 4.0|
Artery, Mineralization | 4 4 | 2 4.0|
Atrium, Thrombosis | X | 3 |
Endocardium, Fibrosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + A + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + A + A + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | | 1 3.0|
Hyperplasia | 2 3 2 2 3 4 3 3 3 | 15 2.7|
Inflammation, Chronic | 3 | 1 3.0|
Mineralization | 3 | 1 3.0|
Necrosis | 4 | 1 4.0|
Vacuolization Cytoplasmic | 2 2 3 3 3 | 14 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + A + A + + M + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 3 2 2 1 2 3 3 | 11 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + A + A + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + M + M I + + + M M M + + M + + + + + M M +| 30 |
Hyperplasia | 4 | 1 4.0|
Hyperplasia, Multiple | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + M + A I + + M + + + + + + + + + + + + + + + +| 46 |
Pars Distalis, Cyst | X X | 3 |
Pars Distalis, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + A A + A + A + + + + + + + + + + + + + + + + + +| 46 |
Ultimobranchial Cyst | X | 2 |
C-Cell, Hyperplasia | 2 2 1 1 3 | 7 1.7|
Follicular Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4| |
DAY ON TEST | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1| |
| 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + A + + + + + + + + + + + + M + + + + + + +| 42 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | | 2 |
Inflammation, Suppurative | 3 3 2 4 4 4 4 4 4 2 4 2 | 23 3.4|
__________________________________________________________________________|____________|
Prostate | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 |
Inflammation, Suppurative | 4 3 | 4 2.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 4 | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 3 3 3 4 2 | 6 3.0|
Artery, Inflammation | 4 4 4 | 10 4.0|
Seminiferous Tubule, Atrophy | 4 3 4 | 6 3.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + A + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node | + + A + A + + + + + + + + + + M + + + + + + + + M| 44 |
Fibrosis | 3 | 1 3.0|
Mediastinal, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + A M + + + M + + M + + M + + + M + + M + M| 29 |
Inflammation, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M A + M + + + + + M + + + M M + + + + + + + + M| 40 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 3 4 | 4 3.3|
Hemorrhage | 4 4 | 2 4.0|
Infarct | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + A + A + + + + M + + + + + + + + + + + + + M +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + M + + + + + M + + + + + + + + + M M + + +| 40 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4| |
DAY ON TEST | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1| |
| 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 4.0|
Gliosis | 3 | 1 3.0|
Hemorrhage | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + A A + A + + A + + + + + + + + A + + + + + + + +| 45 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + A + A + + + + + + + + + + + + + + + + + + + +| 48 |
Foreign Body | | 1 2.0|
Hemorrhage | 4 3 3 3 4 | 7 3.4|
Inflammation, Granulomatous | 2 3 | 3 3.0|
Leukocytosis | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia | 1 2 4 1 | 6 2.0|
Alveolus, Edema | 3 4 | 2 3.5|
Alveolus, Fibrosis | 2 3 | 4 2.8|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 4 3 3 3 2 4 3 2 1 4 3| 17 3.1|
Alveolus, Inflammation, Suppurative | 2 | 5 2.4|
Artery, Inflammation | 4 4 4 | 12 3.8|
Artery, Mineralization | 3 4 4 3 3 4 4 4 3| 22 3.4|
Bronchiole, Infiltration Cellular, | | |
Histiocyte | | 1 4.0|
Bronchiole, Inflammation, Suppurative| 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + A + + A + + + + + + + + + + + + + + + + A + + +| 46 |
Foreign Body | 3 3 | 3 2.7|
Inflammation, Suppurative | 2 2 2 2 3 2 1 2 3 1| 27 2.1|
Inflammation, Membranous | 3 2 | 4 2.5|
Glands, Dilatation | 2 2 3 2 2 2 2 2 2 2 1 3 2 | 20 2.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 1 3 | 3 2.0|
Olfactory Epithelium, Degeneration | 2 3 3 2 2 3 2 2 2 2 3 3 3 2 2 2 2 2 3 2 3 2| 45 2.3|
Olfactory Epithelium, Metaplasia | 2 2 | 6 1.8|
Olfactory Epithelium, Metaplasia, | | |
Squamous | 1 2 1 1 1 2 1 1 3 1 2 | 19 1.8|
Respiratory Epithelium, Hyperplasia | 1 1 1 2 1 1 1 2 2 2 1 1 3 2| 33 1.7|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 2 1 1 1 1 1 1 2 2 2 2 1 1 2 | 40 1.6|
__________________________________________________________________________|____________|
Trachea | + A A + A + + + + + + + + + + + A + + + + + + + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4| |
DAY ON TEST | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1| |
| 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
__________________________________________________________________________|____________|
Lacrimal Gland | + + + + + + + + + | 21 |
Inflammation, Chronic | 3 3 3 3 3 3 3 2 3 | 21 2.9|
Inflammation, Suppurative | | 1 3.0|
Karyomegaly | 3 3 3 3 2 4 3 3 3 | 21 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X | 1 |
Nephropathy, Chronic | 2 4 4 4 4 3 4 4 4 4 4 4 3 4 4 4 4 3 3 4 4 4 4 3| 49 3.6|
Pelvis, Hemorrhage | | 1 2.0|
Pelvis, Hyperplasia | | 2 2.5|
Pelvis, Inflammation, Suppurative | 4 | 2 3.5|
Pelvis, Mineralization | 3 | 3 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | 4 | 2 3.0|
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|
DAY ON TEST | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|
| 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + A + + + + + + + + + A + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | A M M M M M + M M + + M + A + A + A M + A + M M M|
Parasite Metazoan | X X |
Artery, Inflammation | 4 |
__________________________________________________________________________|
Intestine Large, Colon | A + + A + + + + + + + + + A + + + A + + + + A + A|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | A + + A + + + + + + + + + A + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Small | A A + A A + + + + + + + + A + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A A + A A + + + A + + + + M + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | A A + A A A + A + + A + + A + A + A M + A + A + A|
Artery, Inflammation | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | A A + A A A + A + + A + + A + + + A + + A + A + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + A + +|
Angiectasis | 2 |
Clear Cell Focus | |
Hematopoietic Cell Proliferation | |
Necrosis | 4 |
Bile Duct, Cyst | X |
Bile Duct, Fibrosis | 2 2 3 2 |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + |
Artery, Inflammation | 4 |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + A + +|
Atrophy | |
Fibrosis | 4 |
Hemorrhage | |
Infarct | 4 |
Acinus, Hyperplasia | |
Artery, Inflammation | 3 4 4 4 3 4 |
Artery, Thrombosis | X |
__________________________________________________________________________|
Salivary Glands | + + + A + + + + + + + + + + + + + + + + + + A + M|
Inflammation, Chronic | 2 2 2 2 |
Karyomegaly | 1 2 2 2 2 2 2 3 2 2 1 |
__________________________________________________________________________|
Stomach | + + + A + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + M A + +|
Hyperkeratosis | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + A + +|
Cyst | |
Hemorrhage | |
Hyperplasia | |
Inflammation, Necrotizing | |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|
DAY ON TEST | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|
| 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Necrosis | |
Artery, Inflammation | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 1 2 4 2 2 3 |
Inflammation, Suppurative | |
Artery, Inflammation | |
Artery, Mineralization | 3 3 |
Atrium, Thrombosis | X X X X X |
Endocardium, Fibrosis | 4 |
Myocardium, Hemorrhage | 2 |
Ventricle, Thrombosis | X |
Ventricle Right, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 3 3 |
Hypertrophy | 3 |
Infarct | |
Necrosis | 4 |
Vacuolization Cytoplasmic | 3 3 2 3 3 2 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + A + + + + + + + M + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia | 2 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + + + + + M + + + + + + + M M + + M +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 3 2 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + A + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 4 4 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + M + + + + + + + + + + + + + + + + + M I + M|
__________________________________________________________________________|
Preputial Gland | + + + M + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|
DAY ON TEST | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|
| 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | X |
Hyperplasia | |
Inflammation, Suppurative | 3 3 3 4 2 4 2 |
__________________________________________________________________________|
Prostate | + + + A + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Suppurative | 3 4 4 |
Mineralization | 4 |
Artery, Inflammation | 3 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + A + + + + + + + + + + + + + + + + + M A + +|
Inflammation, Suppurative | 3 4 4 |
Artery, Inflammation | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 4 |
Mineralization | 4 4 4 |
Artery, Inflammation | 4 3 4 4 4 2 4 4 |
Seminiferous Tubule, Atrophy | 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + A + +|
Fibrosis | |
__________________________________________________________________________|
Lymph Node | + + + A M + + + + + + + + + + + + + + + + M A + M|
__________________________________________________________________________|
Lymph Node, Bronchial | M + + A M + + + + + + M + + + + + + + + + M M + M|
Hemorrhage | 4 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + A M + + + M + + + + + + + + M + + + M A + M|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 2 |
Inflammation, Suppurative | 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hematopoietic Cell Proliferation | |
Infarct | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M M + + + + + + + + + + +|
Hemorrhage | 3 |
Thrombosis | X |
Artery, Inflammation | 4 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + M + M + + + + + + + M + M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + A + + + + + + + + + + + + + + + + + + + + +|
Osteoporosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|
DAY ON TEST | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|
| 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + A + A + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 |
Artery, Inflammation | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + A + + + + + + + + + + + + + + + + + + A + +|
Hemorrhage | 2 2 |
Inflammation, Granulomatous | 2 |
Alveolar Epithelium, Hyperplasia | 2 1 1 |
Alveolus, Edema | 1 |
Alveolus, Fibrosis | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 3 3 2 3 3 2 1 |
Alveolus, Inflammation, Suppurative | 2 2 2 3 |
Alveolus, Mineralization | 3 |
Artery, Inflammation | 4 4 4 4 4 |
Artery, Mineralization | 3 3 2 3 2 3 3 4 |
Bronchiole, Inflammation, Suppurative| |
__________________________________________________________________________|
Nose | + + + A + + + + + + + + + + + + + + + + + + A + +|
Foreign Body | 2 |
Inflammation, Suppurative | 1 1 2 3 2 3 4 1 2 2 |
Inflammation, Membranous | 1 2 |
Glands, Dilatation | 2 2 1 1 1 1 1 2 1 1|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 2 |
Olfactory Epithelium, Degeneration | 3 2 3 2 2 3 3 2 2 3 4 3 3 3 2 3 2 4 2 3 2 4 3|
Olfactory Epithelium, Metaplasia | 1 1 1 |
Olfactory Epithelium, Metaplasia, | |
Squamous | 2 2 2 2 1 1 1 1 2 2 1 1 1 1 2 2|
Respiratory Epithelium, Hyperplasia | 2 2 3 3 2 2 4 4 2 2 1 1 3 3|
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 3 1 1 2 2 2 3 3 4 2 2 4 1 1 1 1 2 2 3 3|
__________________________________________________________________________|
Trachea | + A + A A + + + + + + + + + + + + + + + + + A + +|
Inflammation, Chronic | |
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
_____________________________________________________________________________________________________________________
| 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|
DAY ON TEST | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|
| 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cataract | |
__________________________________________________________________________|
Harderian Gland | + + + |
Inflammation, Chronic | 2 3 2 |
Karyomegaly | 3 3 |
__________________________________________________________________________|
Lacrimal Gland | M + + + + + |
Hyperplasia | 3 |
Inflammation, Chronic | 3 3 3 3 3 |
Karyomegaly | 4 3 3 4 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +|
Cyst | X X |
Nephropathy, Chronic | 3 3 3 3 4 4 4 3 4 4 4 4 4 4 3 4 4 3 4 4 4 3 4|
Glomerulus, Mineralization | |
Pelvis, Hyperplasia | 3 |
Pelvis, Inflammation, Suppurative | 4 |
Pelvis, Mineralization | 3 |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + A + A + + + + + + + + + + + + + + + + + + A + +|
Hemorrhage | |
Hyperplasia | 3 4 |
Inflammation, Suppurative | 2 3 3 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5| |
DAY ON TEST | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2| |
| 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + A + + A A + + + + + + + + + A A + + A + A A + +| 37 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M M + M M A + M M M A A + M + M M + + M + M A M M| 15 |
Parasite Metazoan | | 2 |
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | A A + + A A + A + + + + + + + A A + + A + A A + +| 34 |
Parasite Metazoan | 2 X | 4 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + A + + + + + + + + + M A + + A + A A + +| 38 |
__________________________________________________________________________|____________|
Intestine Small | + A + + A A + + + + A + + + + A A + + A + A A + +| 34 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + A A + + + + A + + + + A A + + A + A A + +| 33 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + + M A + A + A A A + + + A A + + A + A A + +| 23 |
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A + + A A + A + A A + + + + A A A + A + A A + +| 25 |
__________________________________________________________________________|____________|
Liver | + + + + + A + + + + + + + + + + + + + + + A + + +| 47 |
Angiectasis | 2 | 2 2.0|
Clear Cell Focus | 2 3 1 | 3 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Necrosis | 4 | 2 4.0|
Bile Duct, Cyst | | 1 |
Bile Duct, Fibrosis | 2 2 | 6 2.2|
Bile Duct, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + + + + + + + A + + A + A + + +| 44 |
Atrophy | 3 2 | 2 2.5|
Fibrosis | | 1 4.0|
Hemorrhage | 3 | 1 3.0|
Infarct | | 1 4.0|
Acinus, Hyperplasia | 2 2 | 2 2.0|
Artery, Inflammation | 4 4 4 | 9 3.8|
Artery, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic | 2 | 5 2.0|
Karyomegaly | 1 1 2 2 1 2 2 2 1| 20 1.8|
__________________________________________________________________________|____________|
Stomach | + + + + + A + + + + + + + + + + A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + M + + + A + + + + + + + + + + A + + + + + + + +| 44 |
Hyperkeratosis | 4 | 1 4.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + + + + + + + A + + + + + + + +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5| |
DAY ON TEST | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2| |
| 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cyst | X | 1 |
Hemorrhage | 1 | 1 1.0|
Hyperplasia | 3 | 1 3.0|
Inflammation, Necrotizing | 3 | 1 3.0|
Mineralization | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
Artery, Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 4 2 2 2 3 2 3 2 3 3 2| 19 2.5|
Inflammation, Suppurative | 3 4 | 2 3.5|
Artery, Inflammation | 4 | 1 4.0|
Artery, Mineralization | | 2 3.0|
Atrium, Thrombosis | X X X | 8 |
Endocardium, Fibrosis | | 1 4.0|
Myocardium, Hemorrhage | | 1 2.0|
Ventricle, Thrombosis | | 1 |
Ventricle Right, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 3 2 1 4 2 3 3 | 13 2.5|
Hypertrophy | | 1 3.0|
Infarct | 4 | 1 4.0|
Necrosis | | 1 4.0|
Vacuolization Cytoplasmic | 3 3 3 1 4 3 3 3 3 | 17 2.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
Hemorrhage | | 1 2.0|
Hyperplasia | 3 3 3 4 3 3 2 | 10 2.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + A + + + + A + + +| 45 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + M M M + + M + M + + + + + +| 38 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + A + + + + + + + I + + + + + A M A + + +| 44 |
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Hyperplasia | 3 3 | 4 2.8|
Pars Intermedia, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5| |
DAY ON TEST | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2| |
| 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + A + + + + A + + + + + + + + + + + + + +| 46 |
Ultimobranchial Cyst | X X| 3 |
C-Cell, Hyperplasia | 3 2 3 1 | 7 2.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + I M + + + + M + + + + + A + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + M + + + + M + + + + + + +| 46 |
Cyst | X | 2 |
Hyperplasia | 3| 1 3.0|
Inflammation, Suppurative | 3 4 4 4 4 3 3 3 | 15 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + A + + + + + + + + + + A + + + + + + + +| 46 |
Inflammation, Suppurative | 4 | 4 3.8|
Mineralization | | 1 4.0|
Artery, Inflammation | | 1 3.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + A + + + + + + + + + + A + + + + + + + +| 45 |
Inflammation, Suppurative | 4 | 4 3.8|
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Infarct | | 1 4.0|
Mineralization | 2 3 3 4 | 7 3.4|
Artery, Inflammation | 4 4 4 | 11 3.7|
Seminiferous Tubule, Atrophy | 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + A + + + + + + + + + A A + + + + A + + +| 44 |
Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + M + + + M + M + + + + + + M M +| 38 |
Hemorrhage | 2 4 3 | 6 3.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M| 42 |
Hemorrhage | 2 4 | 3 3.0|
Hyperplasia, Lymphoid | | 2 2.0|
Inflammation, Suppurative | | 2 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + A + + + + + + + + + + A + + + + A + + +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5| |
DAY ON TEST | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2| |
| 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Infarct | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + M + + + + + A + + + + + M + +| 44 |
Hemorrhage | 3 | 2 3.0|
Thrombosis | | 1 |
Artery, Inflammation | | 2 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + M M + M + M + M + + M M M +| 32 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Osteoporosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 4 | 3 3.7|
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + A + + + + + + + + + + A + + A + A + + +| 43 |
Inflammation, Chronic | 2 | 2 2.0|
Inflammation, Suppurative | 1 | 2 1.5|
Artery, Inflammation | 4 | 1 4.0|
Epithelium, Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + A + + + + + + + + + + A + + A + + + + +| 45 |
Hemorrhage | 3 3 2 3 3 4 | 8 2.8|
Inflammation, Granulomatous | 3 | 2 2.5|
Alveolar Epithelium, Hyperplasia | 1 1 | 5 1.2|
Alveolus, Edema | 3 | 2 2.0|
Alveolus, Fibrosis | 2 2 | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 3 3 2 3 4 2 3 4 | 19 2.6|
Alveolus, Inflammation, Suppurative | 2 3 3 | 7 2.4|
Alveolus, Mineralization | | 1 3.0|
Artery, Inflammation | 4 | 6 4.0|
Artery, Mineralization | 3 3 3 3 3 3 3 4 | 16 3.0|
Bronchiole, Inflammation, Suppurative| 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5| |
DAY ON TEST | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2| |
| 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + A + + + + + + + + + A A + + A + A + + +| 43 |
Foreign Body | | 1 2.0|
Inflammation, Suppurative | 3 4 2 3 2 2 2 3 | 18 2.3|
Inflammation, Membranous | 2 2 2 2 2 | 7 1.9|
Glands, Dilatation | 1 1 2 1 1 2 1 2 1 1 2| 21 1.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 2 2 2 2 3 1| 9 2.2|
Olfactory Epithelium, Degeneration | 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 2 2 3 3| 43 2.8|
Olfactory Epithelium, Metaplasia | 2 1 1 2 1 3| 9 1.4|
Olfactory Epithelium, Metaplasia, | | |
Squamous | 2 2 3 2 2 2 2 2 2 2 1 1 2 2 2 1 1 2 3| 35 1.7|
Respiratory Epithelium, Hyperplasia | 2 2 3 3 3 2 1 1 2 2 3 3 4 2 3 3| 30 2.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 2 3 2 2 1 1 2 2 3 3 3 1 2 3 3| 38 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + A + + + + + + + + + + A + + A + A + + +| 42 |
Inflammation, Chronic | 2 2 | 2 2.0|
Artery, Inflammation | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 2 |
Cataract | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + | 8 |
Inflammation, Chronic | 3 3 3 3 3 | 8 2.8|
Karyomegaly | 4 4 3 3 4 | 7 3.4|
__________________________________________________________________________|____________|
Lacrimal Gland | + + | 7 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic | 4 4 | 7 3.3|
Karyomegaly | 3 3 | 7 3.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Cyst | | 2 |
Nephropathy, Chronic | 2 3 4 3 4 4 4 4 3 4 4 4 4 3 4 4 4 4 4 4 4 4 4 3| 47 3.7|
Glomerulus, Mineralization | 3 | 1 3.0|
Pelvis, Hyperplasia | 2 | 2 2.5|
Pelvis, Inflammation, Suppurative | 3 3 | 3 3.3|
Pelvis, Mineralization | 1 | 2 2.0|
Renal Tubule, Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + + A + + + + A + + +| 44 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05080-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:33:24
__________________________________________________________________________________________________________________________________
| 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5| |
DAY ON TEST | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2| |
| 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hemorrhage | 4 | 1 4.0|
Hyperplasia | 3 | 3 3.3|
Inflammation, Suppurative | 3 | 4 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
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