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TDMS Study 05080-01 Pathology Tables

NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24




       Facility:  Battelle Northwest

       Chemical CAS #:  106-92-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 2| 3| 2| 7| 0| 0| 3| 8| 3| 6| 3| 3| 3| 4| 3| 3| 4| 0| 3| 3| 3|             
                                           | 7| 9| 7| 7| 2| 7| 3| 8| 0| 5| 7| 3| 7| 9| 7| 7| 7| 1| 7| 7| 7| 5| 6| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  M  +  +  +  +  +  A  M  +  +  M  M  M  +  +  +  M  +  +  A  +  +  +  +|             
      Parasite Metazoan                    |             2  X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Suppurative            |                                        1                                 |             
      Parasite Metazoan                    |                X           3                                      3      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Parasite Metazoan                    |                                        1              X                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  A  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  A  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Muscularis, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                                       1                  |             
      Eosinophilic Focus                   |                                              3                          X|             
      Hematopoietic Cell Proliferation     |                      2                                         3         |             
      Leukocytosis                         |    4                                                                     |             
      Necrosis                             |                                        3                                 |             
      Vacuolization Cytoplasmic            |                                                                   2      |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                              +                           |             
      Necrosis                             |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
      Palate, Ulcer                        |                                              3                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Karyomegaly                          |                                     1                                    |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                              3                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 2| 3| 2| 7| 0| 0| 3| 8| 3| 6| 3| 3| 3| 4| 3| 3| 4| 0| 3| 3| 3|             
                                           | 7| 9| 7| 7| 2| 7| 3| 8| 0| 5| 7| 3| 7| 9| 7| 7| 7| 1| 7| 7| 7| 5| 6| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Incisor, Developmental Malformation  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2           2              2                 2              3      |             
      Embolus Bacterial                    |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Atrium, Thrombosis                   |    X                 X                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3     4  3     3     4  3  4  4  4        3  3           4  3  3  4     2|             
      Angiectasis, Multiple                |                                                                          |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                      4                                                   |             
      Hyperplasia                          | 3           2  3                                3  3                     |             
      Vacuolization Cytoplasmic            | 3                 1        4  3  3  1        3                    3  1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                3         |             
      Hyperplasia                          |       3  2                                2  3  1                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  M  M  M  +  +  M  M  M  +  M  M  +  +  +  +  M|             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                4                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                   X           X                                X         |             
      C-Cell, Hyperplasia                  | 4     3                       3  1                    2  1              4|             
      Follicular Cell, Cyst                |                                                                          |             
      Follicular Cell, Hyperplasia         |                               3                                      3   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  +  M  +  M  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |       X                                                                  |             
      Inflammation, Suppurative            | 2                             4        2     4  4     4  3  4           4|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X              X                                      X                  |             
      Inflammation, Suppurative            |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 2| 3| 2| 7| 0| 0| 3| 8| 3| 6| 3| 3| 3| 4| 3| 3| 4| 0| 3| 3| 3|             
                                           | 7| 9| 7| 7| 2| 7| 3| 8| 0| 5| 7| 3| 7| 9| 7| 7| 7| 1| 7| 7| 7| 5| 6| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    4        4                    3                                       |             
      Endometrium, Hyperplasia             |             2     2           3              3                    3     3|             
      Endometrium, Metaplasia, Squamous    |                                                                          |             
      Lumen, Dilatation                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         2        1           2                    2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  +  M  +  M  M  +  M  +  M  +  +  +  M  +  M  M  +  M  M  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      3                                         3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  M  A  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Galactocele                          |                      X                    X                              |             
      Inflammation, Suppurative            |    3                                                                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Necrosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                              3                    3      |             
      Hemorrhage                           |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       2                                         1                    1   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                           2                              |             
      Hemorrhage                           |                      2                             3                     |             
      Inflammation, Granulomatous          |                                           2              3               |             
      Leukocytosis                         |    4                                                                     |             
      Thrombosis                           |    X                                                                     |             
      Alveolar Epithelium, Hyperplasia     |                1                          2                             2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 2| 3| 2| 7| 0| 0| 3| 8| 3| 6| 3| 3| 3| 4| 3| 3| 4| 0| 3| 3| 3|             
                                           | 7| 9| 7| 7| 2| 7| 3| 8| 0| 5| 7| 3| 7| 9| 7| 7| 7| 1| 7| 7| 7| 5| 6| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Fibrosis                   |                      2                                                   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2     3              3  3              3  3  2        2        3  4  2  3|             
      Alveolus, Inflammation, Suppurative  |                      3                          1              2  2     3|             
      Artery, Mineralization               | 3     4              4     3        4  4           3     3               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Suppurative            | 4  4                                2     2                              |             
      Glands, Dilatation                   |          2  2     1                 1                                    |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                    4                     |             
      Respiratory Epithelium, Hyperplasia  |          2                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    2                                                                     |             
      Glands, Dilatation                   |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          | +                 +           +                                   +      |             
      Inflammation, Chronic                |                   1           1                                          |             
      Inflammation, Suppurative            | 4                                                                        |             
      Karyomegaly                          |                   1           1                                   2      |             
      Necrosis                             |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  3  2  2  3  2  1  3  3  3  1  1  1     1  2  1  2  2  1  3  1  2  1  1|             
      Pelvis, Dilatation                   |    3                                                                     |             
      Pelvis, Hyperplasia                  |                                              2                           |             
      Pelvis, Mineralization               |       3        1  2        3                             3     1     1   |             
      Renal Tubule, Mineralization         | 2  3        2                    3  3     1     1                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 2| 4| 7|            |
                             DAY ON TEST   | 7| 0| 2| 3| 3| 1| 6| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 0| 7| 2|            |
                                           | 9| 5| 1| 7| 7| 1| 7| 7| 7| 9| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 8| 7| 7| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  47        |
      Acanthosis                           |                                                          4               |      1  4.0|
      Hyperkeratosis                       |                                                          3               |      1  3.0|
      Inflammation, Chronic                |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  M  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +  A  M  +  M  M  +|  34        |
      Parasite Metazoan                    |                                                                         2|      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Parasite Metazoan                    |                                                             X            |      4  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | M  +  +  +  +  A  +  M  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  A|  41        |
      Inflammation, Suppurative            |    1                                                                     |      1  1.0|
      Muscularis, Hyperplasia              |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                      4                                                   |      1  4.0|
      Clear Cell Focus                     |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                              X                           |      3  3.0|
      Hematopoietic Cell Proliferation     |    3  3                                   2     2           1            |      7  2.3|
      Leukocytosis                         |                                                                          |      1  4.0|
      Necrosis                             |                                        4                                 |      2  3.5|
      Vacuolization Cytoplasmic            |    3                                                                     |      2  2.5|
      Bile Duct, Cyst                      |                                                    X                     |      1     |
      Bile Duct, Hyperplasia               |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                   +      |   2        |
      Necrosis                             |                                                                   4      |      1  4.0|
      Ulcer                                |                                                                   4      |      1  4.0|
      Epithelium, Hyperplasia              |                                                                   3      |      1  3.0|
      Palate, Ulcer                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |                      2                                                   |      1  2.0|
      Inflammation, Suppurative            |             2                                                            |      1  2.0|
      Karyomegaly                          | 2                                            1              1            |      4  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 2| 4| 7|            |
                             DAY ON TEST   | 7| 0| 2| 3| 3| 1| 6| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 0| 7| 2|            |
                                           | 9| 5| 1| 7| 7| 1| 7| 7| 7| 9| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 8| 7| 7| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                   +      |   1        |
      Incisor, Developmental Malformation  |                                                                   X      |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2              2                                                         |      7  2.1|
      Embolus Bacterial                    |       X                                                                  |      1     |
      Inflammation, Suppurative            |       4                                                                  |      1  4.0|
      Atrium, Thrombosis                   |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    2  4  3  4  3     4        2  4        4  2  3     2        2        3|     30  3.2|
      Angiectasis, Multiple                |                   4                                                      |      1  4.0|
      Cyst                                 |                         X                                                |      1     |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia                          | 4           3  3     3        2           3  3  2     3              3  3|     16  2.9|
      Vacuolization Cytoplasmic            |             3        3              4        3                           |     13  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hyperplasia                          |    1                          3                                         3|      8  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  M  M  +  +  I  M  M  M  +  M  +  M  M  +  M  M  +  M  +|  26        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                                     X                                    |      1     |
      Pars Distalis, Hyperplasia           |                         1                    4           2               |      4  2.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Ultimobranchial Cyst                 |                X                                                         |      4     |
      C-Cell, Hyperplasia                  |          3                 2              4                              |     10  2.7|
      Follicular Cell, Cyst                |                                  X                                       |      1     |
      Follicular Cell, Hyperplasia         |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 2| 4| 7|            |
                             DAY ON TEST   | 7| 0| 2| 3| 3| 1| 6| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 0| 7| 2|            |
                                           | 9| 5| 1| 7| 7| 1| 7| 7| 7| 9| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 8| 7| 7| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Cyst                                 |                      X           X        X           X  X               |      6     |
      Inflammation, Suppurative            |    4           4                       3     4        2           1      |     15  3.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |             X                                                            |      4     |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |       4           4                       3              4               |      7  3.7|
      Endometrium, Hyperplasia             | 2                 4  3           1           3  3     4              2   |     14  2.7|
      Endometrium, Metaplasia, Squamous    |       3                                   4                              |      2  3.5|
      Lumen, Dilatation                    |                                           4                    3         |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +|  34        |
      Hemorrhage                           |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |       4                                   2     1           2            |      6  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +|  41        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                 X                        |      1     |
      Galactocele                          |                                                                          |      2     |
      Inflammation, Suppurative            |                      2                                                   |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cranium, Necrosis                    |                                                                   4      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Compression                          |    1                                                                     |      3  2.3|
      Hemorrhage                           |                                        4                                 |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 2| 4| 7|            |
                             DAY ON TEST   | 7| 0| 2| 3| 3| 1| 6| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 0| 7| 2|            |
                                           | 9| 5| 1| 7| 7| 1| 7| 7| 7| 9| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 8| 7| 7| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  2.5|
      Inflammation, Granulomatous          |                                           3                              |      3  2.7|
      Leukocytosis                         |                                                                          |      1  4.0|
      Thrombosis                           | X                                                                        |      2     |
      Alveolar Epithelium, Hyperplasia     |                                                    2                     |      4  1.8|
      Alveolus, Fibrosis                   |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 3        2  2     2              3                 3  3        2     3   |     21  2.7|
      Alveolus, Inflammation, Suppurative  |       3     2                 2              2     3  1     1        2   |     13  2.1|
      Artery, Mineralization               |    3  3              3  3     4           3  3     3  3  3           3  3|     20  3.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                   4      |      5  3.2|
      Glands, Dilatation                   |                         2           3        1     1     1               |      9  1.6|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 3  3     2                                                               |      4  3.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                            1                                             |      2  1.5|
      Glands, Dilatation                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                      +                                                   |   5        |
      Inflammation, Chronic                |                      2                                                   |      3  1.3|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Karyomegaly                          |                      3                                                   |      4  1.8|
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 2  2  3  2  1  2  1  3  2  2  2  2  1  2  3  2  2  2  1  2  1  2     2  2|     48  1.9|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Pelvis, Hyperplasia                  |    2                                                        2            |      3  2.0|
      Pelvis, Mineralization               | 2  3     3              3           3     2           1                 1|     15  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 2| 4| 7|            |
                             DAY ON TEST   | 7| 0| 2| 3| 3| 1| 6| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 0| 7| 2|            |
                                           | 9| 5| 1| 7| 7| 1| 7| 7| 7| 9| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 8| 7| 7| 4| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Mineralization         |       3              3                 3  3  4  2           2            |     14  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 5| 5| 3| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 3| 6| 3| 6| 5| 7| 1| 3| 4| 0| 3| 3| 3| 3| 3| 2| 3|             
                                           | 8| 8| 8| 8| 8| 8| 8| 4| 8| 9| 5| 4| 0| 9| 8| 8| 2| 8| 1| 8| 8| 8| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  M  M  +  M  M  +  M  M  +  +  +  +  M  +|             
      Hemorrhage                           |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +|             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
      Parasite Metazoan                    |                                        2                                 |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +|             
      Hyperplasia, Lymphoid                |             2                                                            |             
      Parasite Metazoan                    |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  M  A  M  +  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Angiectasis                          |    3                                                                     |             
      Basophilic Focus                     |                                                                         2|             
      Basophilic Focus, Multiple           |    X                                                                     |             
      Clear Cell Focus                     |                                                                          |             
      Developmental Malformation           |                                                    X                     |             
      Eosinophilic Focus                   |                                              X                           |             
      Hematopoietic Cell Proliferation     |       3                       2           3                              |             
      Necrosis                             |                               2                    3                     |             
      Bile Duct, Hyperplasia               |                                                                         3|             
      Hepatocyte, Cytomegaly               |                                                                      4   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Artery, Inflammation                 |                                  4                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Atrophy                              |                         2     3                                          |             
      Acinus, Hyperplasia                  | 3                                                                        |             
      Artery, Inflammation                 |                                  4                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Karyomegaly                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Acanthosis                           |                3                                                         |             
      Perforation                          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                                                        |             
      Mineralization                       |                            3     3                                       |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 5| 5| 3| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 3| 6| 3| 6| 5| 7| 1| 3| 4| 0| 3| 3| 3| 3| 3| 2| 3|             
                                           | 8| 8| 8| 8| 8| 8| 8| 4| 8| 9| 5| 4| 0| 9| 8| 8| 2| 8| 1| 8| 8| 8| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                         2|             
      Inflammation, Suppurative            |                                                                      4   |             
      Artery, Mineralization               |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Angiectasis                          |    4  4  3  4     4     2  4        2  2     4  2        4  3  4  4      |             
      Hyperplasia                          |    4                       3  3              3  2           2            |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                      4  2           2                    2     4        2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Hyperplasia                          |             3                 3                          2  2            |             
      Hyperplasia, Multiple                |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  M  M  +  +  M  +  +  M  +  +  M  +  +  M  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                         X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                            X  X                                          |             
      C-Cell, Hyperplasia                  |          1           4     3  3           3     2                        |             
      Follicular Cell, Cyst                |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  M  +  +  +  +  +|             
      Cyst                                 | X  2  X  X     X              X                    X                     |             
      Cyst, Multiple                       |                                                                          |             
      Inflammation, Suppurative            | 3                          4     4                    4              2  3|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Cyst                                 |       X     X        X                             X        X  X         |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                          2               |             
      Endometrium, Hyperplasia             | 3  2           2  2     2           2        2           3  2           2|             
      Endometrium, Metaplasia, Squamous    |                               4                                          |             
      Lumen, Dilatation                    |                                                                          |             
      Lumen, Hemorrhage                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 5| 5| 3| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 3| 6| 3| 6| 5| 7| 1| 3| 4| 0| 3| 3| 3| 3| 3| 2| 3|             
                                           | 8| 8| 8| 8| 8| 8| 8| 4| 8| 9| 5| 4| 0| 9| 8| 8| 2| 8| 1| 8| 8| 8| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Wall, Necrosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +                                                                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Hemorrhage               |       3                                                                  |             
      Renal, Hyperplasia, Lymphoid         |                                                    1                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  M  +  +  +  M  +  +  +  +  +|             
      Hemorrhage                           |                                                                      4   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +|             
      Hemorrhage                           |                                                 3        4               |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       3                       3           3        4                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +|             
      Cyst                                 |                                                          X               |             
      Inflammation, Suppurative            |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                              X                           |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          4                    3              3                           |             
      Hemorrhage                           |                      4                       2                           |             
      Ventricle, Dilatation                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Foreign Body                         |                                                          3               |             
      Inflammation, Suppurative            |                            3                             3  2           2|             
      Epithelium, Hyperplasia              |                                                                         2|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |          4                                                               |             
      Inflammation, Granulomatous          | 1        4              3                                3               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 5| 5| 3| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 3| 6| 3| 6| 5| 7| 1| 3| 4| 0| 3| 3| 3| 3| 3| 2| 3|             
                                           | 8| 8| 8| 8| 8| 8| 8| 4| 8| 9| 5| 4| 0| 9| 8| 8| 2| 8| 1| 8| 8| 8| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    2  2  1  2  2                       2     1  1              2        2|             
      Alveolus, Fibrosis                   |                                                                      3  2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1  3  3  3  2  3        1     3        3     3  3     3  3  2  3  2  4  3|             
      Alveolus, Inflammation, Suppurative  |                                                    2                 4  2|             
      Artery, Mineralization               | 3  3                    3  3  3  4              3           3        4   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                      2                             2        2  2         |             
      Glands, Dilatation                   | 2  1  2           2  2  2              3  2     1  3     2     2  2      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                            3                                             |             
      Olfactory Epithelium, Degeneration   | 2  1  1  1  1  1  1  2  2  2  2  2  1  1  2  1  2  3     1     3  2  3  2|             
      Olfactory Epithelium, Metaplasia     |                                                                2  1      |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |                            1  1           2        2           2     2   |             
      Respiratory Epithelium, Hyperplasia  |                         1        1  1     2     1  2     1  1     1  1   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 2  1        1  1  1  1  1     1  1  2  1  2  1  1  2     1     1  2  1  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 2                                                                        |             
      Mineralization                       |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                    +      |             
      Cataract, Multiple                   |                                              3                           |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Karyomegaly                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Cyst                                 |                                                                      X   |             
      Nephropathy, Chronic                 | 1  2  2  2  2  1  1  2  2  3  3  4  1  2     2  1  1     2  1  2  2  2  2|             
      Pelvis, Hyperplasia                  |                               3                                2         |             
      Pelvis, Mineralization               |                   2        2  4                    2           3         |             
      Renal Tubule, Degeneration           |             4                                                            |             
      Renal Tubule, Mineralization         |                      2  2     3  4  2  2  2  2                    2  2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    3                     |             
      Inflammation, Suppurative            |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3|            |
                                           | 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS FEMALE              | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  M  +  M  +  M  +  +  +  M  +|  35        |
      Hemorrhage                           |                                                                3         |      1  3.0|
      Parasite Metazoan                    |       2                                               2                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Inflammation, Suppurative            |                                                                      4   |      1  4.0|
      Necrosis                             |                                                                      4   |      1  4.0|
      Parasite Metazoan                    |                                  3                                       |      2  2.5|
      Ulcer                                |                                                                      4   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                  3        2                              |      3  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                      3                    2                              |      3  2.7|
      Basophilic Focus                     |       3                                                                  |      2  2.5|
      Basophilic Focus, Multiple           |                                                                          |      1     |
      Clear Cell Focus                     | 2                                                                        |      1  2.0|
      Developmental Malformation           |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                               3                                          |      4  2.8|
      Necrosis                             |                               3                                          |      3  2.7|
      Bile Duct, Hyperplasia               |             2        1                                                   |      3  2.0|
      Hepatocyte, Cytomegaly               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |    3                                                                     |      3  2.7|
      Acinus, Hyperplasia                  |          3                                                               |      2  3.0|
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
      Karyomegaly                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Acanthosis                           |                               4                                         3|      3  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3|            |
                                           | 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS FEMALE              | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Perforation                          |                               X                                          |      1     |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy                       |                4        3                                      2         |      4  2.8|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Artery, Mineralization               |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          | 3  4  3  3  2  3     4     4     4  2  4     3  4  4  4  3  4  3  4  2  2|     36  3.3|
      Hyperplasia                          |       3  4  2     2                                                     4|     11  2.9|
      Necrosis                             |                                                                      3   |      1  3.0|
      Vacuolization Cytoplasmic            | 3  4     4                       3     3                                 |     11  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |       1              3           2     3                    2           1|     10  2.2|
      Hyperplasia, Multiple                |                3                    3                                    |      2  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  +  +  M  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  M  M  M|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | I  +  +  +  +  +  A  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Pars Distalis, Cyst                  |                                                       X                  |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  I  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Ultimobranchial Cyst                 |    X  X  X  X                          X  X                    X         |      9     |
      C-Cell, Hyperplasia                  | 3                          1                       2  4  4        3      |     12  2.8|
      Follicular Cell, Cyst                |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  45        |
      Cyst                                 |                X           X                    X  X        X            |     12  2.0|
      Cyst, Multiple                       |    X                                                                     |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3|            |
                                           | 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS FEMALE              | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |    4  4     4                    4        4        4           4         |     13  3.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                            X                 X  X     X                  |     10     |
      Inflammation, Suppurative            |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Endometrium, Hyperplasia             |             2  2                 2  3  2  3  2  2     3  4  3           1|     22  2.3|
      Endometrium, Metaplasia, Squamous    |                2  2              4                                      4|      5  3.2|
      Lumen, Dilatation                    |                                  4           4                 4        4|      4  4.0|
      Lumen, Hemorrhage                    |                                  4                          3            |      2  3.5|
      Wall, Necrosis                       |                                                 4                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesenteric, Hemorrhage               |                                                                          |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  M  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +  +|  39        |
      Hemorrhage                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|  45        |
      Hemorrhage                           |                                                                          |      2  3.5|
      Hyperplasia, Lymphoid                | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                               4                                          |      5  3.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |    X           X                                               X         |      4     |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                                                          |      1     |
      Inflammation, Suppurative            |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                      4   |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrous Osteodystrophy               |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3|            |
                                           | 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS FEMALE              | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |    4           3                                                         |      5  3.4|
      Hemorrhage                           |                                                                          |      2  3.0|
      Ventricle, Dilatation                |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Foreign Body                         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                   1      |      5  2.2|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  4.0|
      Inflammation, Granulomatous          |          2     2     2                                                   |      7  2.4|
      Alveolar Epithelium, Hyperplasia     |    2           2                          2           2                  |     14  1.8|
      Alveolus, Fibrosis                   |                                                                          |      2  2.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1  3  3  3  2  3  2  3        3  3  1  3  3  3  3  3  3  1  1  3  3  3  2|     41  2.6|
      Alveolus, Inflammation, Suppurative  |                               2           1                              |      5  2.2|
      Artery, Mineralization               | 3  3           3     3                    3  3  3                        |     16  3.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            | 2     2                                                              3   |      7  2.1|
      Glands, Dilatation                   | 2  2     2  2  3     3              3  2  1  3  2        2  3  3     2  2|     29  2.2|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
      Olfactory Epithelium, Degeneration   | 2  1  1  1  1  1  1  2     1  2  1  1  1  1  2  1  2     2  2  1  2  2  2|     46  1.6|
      Olfactory Epithelium, Metaplasia     | 1                          2                                             |      4  1.5|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Squamous                        | 1                                                  1                 1   |      9  1.4|
      Respiratory Epithelium, Hyperplasia  | 1        1     1     1     1  1        1     1                           |     18  1.1|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 2        1  1  1  1  2     1  1     1  1     1  1  1  1           1  1  1|     37  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +                                       |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3|            |
                                           | 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS FEMALE              | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cataract, Multiple                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                            +                                             |   1        |
      Hyperplasia                          |                            3                                             |      1  3.0|
      Inflammation, Chronic                |                            2                                             |      1  2.0|
      Karyomegaly                          |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                                          |      1     |
      Nephropathy, Chronic                 | 2  1  2  1  1        2  2  2  2  1  2  2  2  1  2     2     2     1  1   |     42  1.8|
      Pelvis, Hyperplasia                  |                                                                      3   |      3  2.7|
      Pelvis, Mineralization               | 2                                3     3  2        3  3     1  1     2  3|     15  2.4|
      Renal Tubule, Degeneration           |                                                                          |      1  4.0|
      Renal Tubule, Mineralization         |    3  2  2  2  2        2                                2               |     18  2.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 5| 7| 7| 6| 0| 5| 7| 7| 7| 7| 4| 6| 7| 7| 2| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 7| 0| 3| 5| 3| 7| 3| 3| 3| 3| 0| 6| 3| 1| 2| 3| 2| 2| 3| 3| 3|             
                                           | 1| 9| 9| 9| 0| 5| 9| 2| 1| 8| 9| 9| 9| 9| 9| 8| 9| 5| 0| 9| 4| 4| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | M  +  +  +  M  +  +  +  M  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
      Granuloma                            |                      3                                                   |             
      Inflammation                         |                                                                      4   |             
      Parasite Metazoan                    |          2                                         3                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Parasite Metazoan                    |          2                                         3                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  I  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        1                                 |             
      Clear Cell Focus                     |                                                                      2   |             
      Developmental Malformation           |                                                                          |             
      Hematopoietic Cell Proliferation     |          2                                                               |             
      Inflammation, Suppurative            |                      2                                                   |             
      Leukocytosis                         |                                                                          |             
      Necrosis                             |                         4                                                |             
      Bile Duct, Cyst                      |                                        X                                 |             
      Bile Duct, Hyperplasia               |             1        2                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +     +                                         +   |             
      Artery, Inflammation                 |                                                                      4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                |          2                                                               |             
      Artery, Inflammation                 |                4                                                     4  4|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Karyomegaly                          |                                        1                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                      4                 3                                 |             
      Hyperkeratosis                       |                      4                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Erosion                              |                4                                                         |             
      Inflammation, Suppurative            |                3                                                         |             
      Mineralization                       |                4                                               4         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2                       2                                   3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 5| 7| 7| 6| 0| 5| 7| 7| 7| 7| 4| 6| 7| 7| 2| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 7| 0| 3| 5| 3| 7| 3| 3| 3| 3| 0| 6| 3| 1| 2| 3| 2| 2| 3| 3| 3|             
                                           | 1| 9| 9| 9| 0| 5| 9| 2| 1| 8| 9| 9| 9| 9| 9| 8| 9| 5| 0| 9| 4| 4| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Artery, Mineralization               |                                                                4         |             
      Myocardium, Mineralization           |                                                                4         |             
      Myocardium, Necrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3     2     2  3  3           3                    3     4  3        4   |             
      Atrophy                              |                                              4                           |             
      Hemorrhage                           |                                                                      4   |             
      Hyperplasia                          |    3  3                          3     3           3           4  4      |             
      Vacuolization Cytoplasmic            |                      2                                            4     3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  3                             3         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  M  +  M  M  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                              3                           |             
      Pars Distalis, Hyperplasia           |                      2                          3                 3      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                X                                                  X      |             
      C-Cell, Hyperplasia                  |                               2     1                    3     3        3|             
      Follicular Cell, Hyperplasia         |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Cyst                                 |    X           X                 X        X  X           X           X  X|             
      Inflammation, Suppurative            |       4                       4        3     3  3        3     3         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X     X                 X     X        X        X               |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 3                                                                 4      |             
      Thrombosis                           |                                                                          |             
      Artery, Inflammation                 |                                                                      4   |             
      Endometrium, Hyperplasia             |                2  2                             4                 3      |             
      Endometrium, Metaplasia, Squamous    |          4        3                                               2      |             
      Lumen, Dilatation                    |                                                 4                 4     3|             
      Lumen, Hemorrhage                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 5| 7| 7| 6| 0| 5| 7| 7| 7| 7| 4| 6| 7| 7| 2| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 7| 0| 3| 5| 3| 7| 3| 3| 3| 3| 0| 6| 3| 1| 2| 3| 2| 2| 3| 3| 3|             
                                           | 1| 9| 9| 9| 0| 5| 9| 2| 1| 8| 9| 9| 9| 9| 9| 8| 9| 5| 0| 9| 4| 4| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +|             
      Fibrosis                             |                3                                                         |             
      Hemorrhage                           |                                                                3         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                                               |             
      Hematopoietic Cell Proliferation     |          3                                2        3                     |             
      Artery, Inflammation                 |                                                                      4   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |          X                                                               |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                4         |             
      Osteopetrosis                        |                                                                4         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                      +     +                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Gliosis                              |          2                                                               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                              +                           |             
      White Matter, Degeneration           |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                               3                                          |             
      Inflammation, Granulomatous          |       3                       4                                      2   |             
      Alveolar Epithelium, Hyperplasia     |                1                       2        1  2     2  2        1   |             
      Alveolus, Fibrosis                   |                1                                               1         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 5| 7| 7| 6| 0| 5| 7| 7| 7| 7| 4| 6| 7| 7| 2| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 7| 0| 3| 5| 3| 7| 3| 3| 3| 3| 0| 6| 3| 1| 2| 3| 2| 2| 3| 3| 3|             
                                           | 1| 9| 9| 9| 0| 5| 9| 2| 1| 8| 9| 9| 9| 9| 9| 8| 9| 5| 0| 9| 4| 4| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Histiocyte                      |             3  3  2                 3  3     2  2  3     3  3  3     3   |             
      Alveolus, Inflammation, Suppurative  |                                                          2               |             
      Artery, Inflammation                 |                                                                      4   |             
      Artery, Mineralization               |    3  4  3                    3  4              3  3        3     3  3  3|             
      Bronchiole, Hyperplasia              |                2                                                         |             
      Pleura, Inflammation, Chronic        |          4                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    1        2  2              2     2                    2           3   |             
      Glands, Dilatation                   |       2  3        3           2  2  2  2  2     2  2     2  2  2  2  3  2|             
      Olfactory Epithelium, Degeneration   | 2  3  2  3  3  3  3  4        3  2  2  2  3  2  2  2  3  3  4  3  2  4  2|             
      Olfactory Epithelium, Metaplasia     |    2                          1                                1         |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        | 2  2  1  1  1  2  2  3        2           2           1  2  3  2  1      |             
      Respiratory Epithelium, Dysplasia    |                      4                                                   |             
      Respiratory Epithelium, Hyperplasia  | 3        1           4                    2        3  2     2  3        1|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 3  2     1  1  1  1  4                    2        3  2     2  3     1  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                +                                                         |             
      Inflammation, Chronic                |                2                                                         |             
      Karyomegaly                          |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        X                                X|             
      Nephropathy, Chronic                 | 2  1  2  3  2  3  2  1  2  1  3  3  1  1  1  1  1  1  2  2  2  4  1  3  2|             
      Pelvis, Hyperplasia                  |       2                                            1                     |             
      Pelvis, Mineralization               |    2     3                             3  2  4  2  3     2               |             
      Renal Tubule, Mineralization         |       2  3        2  2  2                          3        3  3     2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3|            |
                                           | 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS FEMALE              | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  M  +|  38        |
      Granuloma                            |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  4.0|
      Parasite Metazoan                    |                1                                                         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
      Parasite Metazoan                    |                      3                                X  3               |      5  2.8|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Angiectasis                          | 3                                                     4                  |      3  2.7|
      Clear Cell Focus                     |                                                             2            |      2  2.0|
      Developmental Malformation           |                                  X                                       |      1     |
      Hematopoietic Cell Proliferation     |          2                          2                                    |      3  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Leukocytosis                         |                2                                                         |      1  2.0|
      Necrosis                             |                                           4           4                  |      3  4.0|
      Bile Duct, Cyst                      |                                                                          |      1     |
      Bile Duct, Hyperplasia               |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Atrophy                              | 2                                               2                        |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Artery, Inflammation                 |                                     4  3                                 |      5  3.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
      Inflammation, Chronic                |                                        2                                 |      1  2.0|
      Karyomegaly                          |                               1                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|  46        |
      Acanthosis                           |                                                                          |      2  3.5|
      Hyperkeratosis                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  I|  44        |
      Erosion                              |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3|            |
                                           | 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS FEMALE              | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                            2        4                                    |      5  2.6|
      Inflammation, Suppurative            |                2                                                         |      1  2.0|
      Artery, Mineralization               |                                                                          |      1  4.0|
      Myocardium, Mineralization           |                                                                          |      1  4.0|
      Myocardium, Necrosis                 |                                     4                                    |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Angiectasis                          | 3     4              2           4     2  2  3     3     3  4  2        4|     22  3.0|
      Atrophy                              |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia                          |             3           2                       3     2  3               |     12  3.0|
      Vacuolization Cytoplasmic            |    2  3     3                 4              2  2                        |      9  2.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +|  47        |
      Hyperplasia                          |                2              3                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  +  +  +  M  +  M  M  M  +  +  M  +  +  M  M  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |                2                                               4         |      5  2.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  47        |
      Ultimobranchial Cyst                 |                                        X  X                              |      4     |
      C-Cell, Hyperplasia                  |                            3     3                 3  2  3               |     10  2.6|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  A  M  +|  43        |
      Cyst                                 |    X        X              X     X                 X     X               |     14     |
      Inflammation, Suppurative            |    3        3           3     2        4           2           4        4|     15  3.2|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Cyst                                 | X                       X                                                |      8     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3|            |
                                           | 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS FEMALE              | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Capsule, Hyperplasia                 |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                     3                                    |      3  3.3|
      Thrombosis                           |                                     X                                    |      1     |
      Artery, Inflammation                 |                                                                          |      1  4.0|
      Endometrium, Hyperplasia             |                      4        4  4           4              4  2     2  3|     12  3.2|
      Endometrium, Metaplasia, Squamous    |                               2     4                             4      |      6  3.2|
      Lumen, Dilatation                    |                                                                          |      3  3.7|
      Lumen, Hemorrhage                    |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  M  +|  43        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +|  44        |
      Hyperplasia, Lymphoid                |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |          2     2                    2     3           3                  |      8  2.5|
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +|  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                               X                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                   3     3                                                |      2  3.0|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hyperkeratosis                       |                   4                                                      |      1  4.0|
      Inflammation, Suppurative            |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  4.0|
      Osteopetrosis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3|            |
                                           | 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS FEMALE              | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |             2                                            3               |      2  2.5|
      Gliosis                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      White Matter, Degeneration           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Foreign Body                         |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      3  3.0|
      Alveolar Epithelium, Hyperplasia     | 1                 3        2  2        2     2                          2|     14  1.8|
      Alveolus, Fibrosis                   |                                                                          |      2  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 3  3  2     3  4  4     2  3  3     3  3  3  3  3        2  3  2     1  3|     31  2.8|
      Alveolus, Inflammation, Suppurative  |                1  2                                   1                  |      4  1.5|
      Artery, Inflammation                 |                                                                          |      1  4.0|
      Artery, Mineralization               |                   3                    3              3     3            |     15  3.1|
      Bronchiole, Hyperplasia              |                                                                          |      1  2.0|
      Pleura, Inflammation, Chronic        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |
      Inflammation, Suppurative            |             2                    4                 2     2               |     11  2.2|
      Glands, Dilatation                   | 1  2  2  2  3  2  2  3  2  1  2     3  3  3  2  1  3  3  2  2  2     2  2|     39  2.2|
      Olfactory Epithelium, Degeneration   | 3  2  3  3  4  3  3  3  2  3  3  3  3  3  3  2  2  3  4  3  4  3     3  2|     47  2.8|
      Olfactory Epithelium, Metaplasia     |                                  2        2                 2            |      6  1.7|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Squamous                        |       1     2  2     1     2  1  2  2  2  2  1     2  3  1  2        2   |     31  1.8|
      Respiratory Epithelium, Dysplasia    |                                                                          |      1  4.0|
      Respiratory Epithelium, Hyperplasia  |       1  2  1  1     3           3  2     1        2  3  2     2     3   |     22  2.1|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 1  1  1  3  2  2  2  3  1  1  2  2  2  2  2  1  1  3  3  3  1  2     3  2|     38  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          | +                                                                        |   2        |
      Inflammation, Chronic                | 2                                                                        |      2  2.0|
      Karyomegaly                          | 3                                                                        |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3|            |
                                           | 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS FEMALE              | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Cyst                                 |                                                                         X|      3     |
      Nephropathy, Chronic                 | 2  2  1  1  3  2  1     2  1  1  1  1  2  1  1  2     1  3  2        1  1|     46  1.7|
      Pelvis, Hyperplasia                  |                                                                          |      2  1.5|
      Pelvis, Mineralization               |          2  2     2              2                       2     2        2|     15  2.3|
      Renal Tubule, Mineralization         |             2                                1                           |     11  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |
      Hemorrhage                           |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|             
                             DAY ON TEST   | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|             
                                           | 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | M  +  +  +  +  +  M  M  M  +  +  M  M  +  A  M  M  M  M  +  +  +  +  M  +|             
      Parasite Metazoan                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A  +  M  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                       X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  A  A  I  A  +  +  +  +  +  +|             
      Parasite Metazoan                    | 2                       X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  A  A  A  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  A  A  A  M  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  A  +  +  +  +  A  A  A  +  +  A  +  +  A  A  A  A  A  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  +  +  +  +  A  A  A  +  +  A  +  +  A  A  A  A  A  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Angiectasis                          |             1                                                            |             
      Basophilic Focus                     |             1                                                            |             
      Clear Cell Focus                     |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Granulomatous          |                                                             4            |             
      Bile Duct, Fibrosis                  |                2                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                             +            |             
      Inflammation                         |                                                             4            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Atrophy                              |                                                    2                     |             
      Acinus, Hyperplasia                  |                               2                                          |             
      Artery, Inflammation                 |       4        4           4                                3     4      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             1  2  2  2  2  3  3     2  3                                1|             
      Inflammation, Suppurative            |                                                                          |             
      Karyomegaly                          |       2  2  2  2  3  2  2  3  2     2  2  2  2  3           2            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Artery, Inflammation                 |                                                             4            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Mineralization                       |                            4                                             |             
      Artery, Inflammation                 |                                                             4     3      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                               +              +                           |             
      Hyperplasia, Squamous                |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1           4           3           3  2        1        3  2        2|             
      Aortic Valve, Mineralization         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|             
                             DAY ON TEST   | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|             
                                           | 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation                 |                                                             3            |             
      Artery, Mineralization               |                            4  3                                         3|             
      Atrium, Mineralization               |                                                                          |             
      Atrium, Thrombosis                   |       X        X                                                        X|             
      Ventricle, Mineralization            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |          1           1                    2              4               |             
      Vacuolization Cytoplasmic            |                                                    3                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Hyperplasia                          |    2        1                       1           2                        |             
      Hyperplasia, Multiple                |                               2                                          |             
      Mineralization                       |                                                                3         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  I  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                   2                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A  +  +  +  A  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                            2  1                    1     1           1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |          +                       +                                       |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | M  +  M  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            X                 X                 X         |             
      Inflammation, Suppurative            | 4  4  4  1           3  3  4  4  3        4              3  3     3      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    4                                      4                              |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                           4  2                           |             
      Artery, Inflammation                 |                                                             4            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Artery, Inflammation                 |       4        4           4                                4            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|             
                             DAY ON TEST   | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|             
                                           | 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Seminiferous Tubule, Atrophy         |                4                                   4        2  3        2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia, Lymphoid                |                               4                                          |             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  M  +  +  +  M  M  +  +  +  +  +  M  M  +  A  +  +  +  +  M  +|             
      Hemorrhage                           |       3        2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hemorrhage                           |                      2                                                   |             
      Hyperplasia, Lymphoid                |                2                                                         |             
      Infiltration Cellular, Histiocyte    |             2                                                            |             
      Inflammation, Chronic                |                               2                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Artery, Inflammation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  M  M  +  +  +  +  M  +  +  +  +  A  +  M  M  M  M  +  M  M  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Giant Cell                           |                                                                          |             
      Granuloma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |       +                                                                  |             
      Laryngeal, Degeneration              |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Demyelination                        |                                                 1                        |             
      Hemorrhage                           |                                     3                                3   |             
      Thrombosis                           |                                                                          |             
      Ventricle, Dilatation                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | A  A  +  +  +  +  +  A  +  +  +  A  +  +  A  A  A  +  A  +  +  +  +  +  +|             
      Inflammation, Chronic                |          2                                                               |             
                                            __________________________________________________________________________|             
   Lung                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  A  +  +  +  +  +  +|             
      Foreign Body                         |             3                                                            |             
      Hemorrhage                           |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|             
                             DAY ON TEST   | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|             
                                           | 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Granulomatous          |             3           2                                                |             
      Alveolar Epithelium, Hyperplasia     |       2        1                                                         |             
      Alveolus, Edema                      |                         2                                                |             
      Alveolus, Fibrosis                   |       2        2                                                         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       3        3        2                                                |             
      Alveolus, Inflammation, Suppurative  |       3        2  2        1           1                                2|             
      Artery, Inflammation                 |                3     2        3                             3            |             
      Artery, Mineralization               |                            3           2           3     2  3  3  3  2   |             
      Bronchiole, Inflammation, Suppurative|             2                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|             
      Foreign Body                         |          2                                                               |             
      Inflammation, Suppurative            |       1  2                                                               |             
      Inflammation, Membranous             |          2           2                                      1            |             
      Glands, Dilatation                   | 3     4  2                             2                          2      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     | 4                       2                                                |             
      Respiratory Epithelium, Hyperplasia  |                                  1                       2               |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                            1     2                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | A  A  +  +  +  +  +  A  +  +  +  A  +  +  A  A  A  +  A  +  +  +  A  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
      Hyperplasia                          |                         3                                                |             
      Inflammation, Chronic                |                         2                                                |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |    +  +  +  +  +              +        +  +        +        +  +  +     +|             
      Inflammation, Chronic                |    1  1  2  3  3              2        3  2        3        3  3  3     3|             
      Karyomegaly                          |    1  3  3  3  3              3        3  3        3        3  3  3     3|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                                                         |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |    3                                                                     |             
      Nephropathy, Chronic                 | 2  4  4  3  3  4     4  3  4  3  3  3  3  4  4  3  3  4  4  4  4  3  3  4|             
      Artery, Mineralization               |                                                                          |             
      Pelvis, Hyperplasia                  |    3                                                           3         |             
      Pelvis, Mineralization               |    1                                                                     |             
      Renal Tubule, Mineralization         |                            3                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  +  +  +|             
      Calculus Gross Observation           |    X                                               X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|             
                             DAY ON TEST   | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|             
                                           | 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Calculus Micro Observation Only      |                   X                                X                     |             
      Hyperplasia                          |    4                                                                     |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5|            |
                             DAY ON TEST   | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4|            |
                                           | 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  A  +  +  A  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  M  A  +  +  A  +  +  +  +  M  M  M  M  A  A  M  +  A  M  +  M  M  M|  23        |
      Parasite Metazoan                    | X                                                                        |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  A  +  +  A  A  +|  39        |
      Parasite Metazoan                    |                            X                                            2|      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  +  +  +  A  +  +|  40        |
      Parasite Metazoan                    |       X  X                                                               |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  A  +  +  A  +  +  +  +  A  +  +  +  A  +  A  +  A  +  +  A  A  +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  A  +  +  +  +  A  +  +  +  A  A  A  +  A  +  +  A  A  +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  A  +  +  A  +  A  A  A  +  A  A  A  +  A  A  +  A  A  A|  24        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  A  +  +  A  +  A  A  A  +  A  A  A  +  A  A  +  A  A  A|  24        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |                                                                          |      1  1.0|
      Clear Cell Focus                     |    X                                                                     |      1     |
      Developmental Malformation           |                                                          X               |      1     |
      Hematopoietic Cell Proliferation     |                                                                         3|      1  3.0|
      Inflammation, Granulomatous          | 2                                                     2                  |      3  2.7|
      Bile Duct, Fibrosis                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                      2                                                   |      2  2.0|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Artery, Inflammation                 |                                                                   4      |      6  3.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 1                                                     1                  |     12  1.9|
      Inflammation, Suppurative            |                      1                          3                        |      2  2.0|
      Karyomegaly                          |    2     2           2  2                 1           1                  |     21  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  I  +  +  M  +  +  +  +  +  +|  45        |
      Inflammation, Suppurative            |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mineralization                       |                                                             3     4     3|      4  3.5|
      Artery, Inflammation                 |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
      Hyperplasia, Squamous                |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5|            |
                             DAY ON TEST   | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4|            |
                                           | 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                        2                       2  3      |     12  2.3|
      Aortic Valve, Mineralization         |             3  3                                                         |      2  3.0|
      Artery, Inflammation                 |                                                                         3|      2  3.0|
      Artery, Mineralization               |                               4                          3  3     4      |      7  3.4|
      Atrium, Mineralization               |                                              3                           |      1  3.0|
      Atrium, Thrombosis                   |                X                             X  X           X           X|      8     |
      Ventricle, Mineralization            |                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                                         4|      1  4.0|
      Hyperplasia                          |                      1  1                          2                 3   |      8  1.9|
      Vacuolization Cytoplasmic            | 4     2           4              2           3  2     3        3  2      |     10  2.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          | 3                             3                 2           2     2  3   |     10  2.1|
      Hyperplasia, Multiple                |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  M  +  M  +|  36        |
      Hyperplasia                          |                                                                   3     2|      2  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|  47        |
      Pars Distalis, Cyst                  |                                                                X        X|      2     |
      Pars Distalis, Hyperplasia           |                                                                2         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  A  +  +  +  +  +|  43        |
      Inflammation, Chronic                |                            2                                             |      1  2.0|
      Ultimobranchial Cyst                 |                                           X     X                    X  X|      4     |
      C-Cell, Hyperplasia                  |    2              2     2     3                             1            |     10  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  43        |
      Artery, Inflammation                 |                                                                         4|      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5|            |
                             DAY ON TEST   | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4|            |
                                           | 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                      X        X              X        X                  |      7     |
      Inflammation, Suppurative            | 3           4     4        2                 3  2           4        3  2|     22  3.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                             1            |      3  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                         2|      3  2.7|
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Mineralization                       |       2                                                                  |      1  2.0|
      Artery, Inflammation                 |    4              3     4              3                          4     4|     10  3.8|
      Seminiferous Tubule, Atrophy         |    4                                                                    4|      7  3.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Renal, Hemorrhage                    |                                        2        2              2         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  40        |
      Hemorrhage                           |                                                 3                 3     3|      5  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|  44        |
      Hemorrhage                           |                                                 3                        |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Artery, Inflammation                 |                3                                                         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  M  +  +  M  +  +  +  +  M  M  +  M  M  +  +  M  M  +  M  +  +  M|  27        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Giant Cell                           |       4                                                                  |      1  4.0|
      Granuloma                            |       4                                                                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Laryngeal, Degeneration              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5|            |
                             DAY ON TEST   | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4|            |
                                           | 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                      X                                                   |      1     |
      Demyelination                        |                                                                          |      1  1.0|
      Hemorrhage                           |                               2                                      3   |      4  2.8|
      Thrombosis                           |                                                             X            |      1     |
      Ventricle, Dilatation                |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  A  +  +  +  +  A  +  +|  39        |
      Inflammation, Chronic                |                         2                                                |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +|  42        |
      Foreign Body                         |                                                                          |      1  3.0|
      Hemorrhage                           |                      2     3                    3           4     4     3|      7  3.0|
      Inflammation, Granulomatous          |                   3              3                       3               |      5  2.8|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.5|
      Alveolus, Edema                      |                                                                          |      1  2.0|
      Alveolus, Fibrosis                   |                                                                          |      2  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |       2                    2                                   2        3|      7  2.4|
      Alveolus, Inflammation, Suppurative  |                                                                          |      6  1.8|
      Artery, Inflammation                 |       4                 1              2                                 |      7  2.6|
      Artery, Mineralization               | 3     4           2  2     3     3              2        3        3  3   |     18  2.7|
      Bronchiole, Inflammation, Suppurative|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +  +|  44        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |    1                 3     1                    1        1  2           2|      9  1.6|
      Inflammation, Membranous             |                                                                          |      3  1.7|
      Glands, Dilatation                   |    1                       2                             1               |      8  2.1|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 2              2     4        2                 3                        |      7  2.7|
      Respiratory Epithelium, Hyperplasia  |                         1                                               1|      4  1.3|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                             1           1|      4  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  40        |
      Inflammation, Suppurative            |    1                                                                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5|            |
                             DAY ON TEST   | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4|            |
                                           | 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                     +        +     A                     |   3        |
      Hyperplasia                          |                                     4                                    |      2  3.5|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          | +  +              +           +                       +  +               |  19        |
      Inflammation, Chronic                | 3  3              3           3                       3  2               |     19  2.6|
      Karyomegaly                          | 4  3              4           4                       3  3               |     19  3.1|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Hemorrhage                           |                            4                                             |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Nephropathy, Chronic                 | 4  4  2  4  4  4  3  3  4  4  4  3  3  4  2  4  4  3  4  3  4  4  4  3  4|     49  3.5|
      Artery, Mineralization               |                                                                   4      |      1  4.0|
      Pelvis, Hyperplasia                  |                                                                          |      2  3.0|
      Pelvis, Mineralization               |       2                       2                                          |      3  1.7|
      Renal Tubule, Mineralization         |                                                                   4      |      2  3.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Calculus Gross Observation           |                                                                          |      2     |
      Calculus Micro Observation Only      |                                                          X               |      3     |
      Hyperplasia                          |                                                 3                        |      2  3.5|
      Inflammation, Chronic                |                                                 3                        |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|             
                             DAY ON TEST   | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|             
                                           | 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  A  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | M  M  +  +  A  +  +  +  M  M  +  M  +  M  +  +  +  M  +  A  +  +  M  M  A|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 2                 3     3|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  A  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                                                  |             
      Artery, Inflammation                 |       4                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  A  +  +  A  +  +  +  A  +  +  A  +  A  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  A  A  +  A  +  +  +  A  M  +  A  +  A  +  +  +  +  +  A  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  +  +  A  +  +  +  A  M  +  A  +  A  +  +  +  +  +  A  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                3                                                         |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                2                                3     2                 X|             
      Hematopoietic Cell Proliferation     |          3                                                               |             
      Inflammation, Suppurative            |                                                    3                     |             
      Necrosis                             |                                                    3                 3   |             
      Bile Duct, Fibrosis                  |                                                    3                     |             
      Bile Duct, Hyperplasia               |                                                    3                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      2        3                             2            |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                    3                     |             
      Acinus, Hyperplasia                  |                                                                         3|             
      Artery, Inflammation                 |       4                    4                          3  3              4|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X                                    |             
      Inflammation, Chronic                |                               2              2  1                        |             
      Inflammation, Granulomatous          |                                     4                                    |             
      Karyomegaly                          |       1  3  2  2  3  2  2  1  2     2     1  2  1  2                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation                 |                                                    3                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Acanthosis                           |                                                                3         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|             
                             DAY ON TEST   | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|             
                                           | 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       |    2        2                                2     2     2              2|             
      Artery, Inflammation                 |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Atrium, Thrombosis                   |          X           X                                                   |             
      Endocardium, Fibrosis                |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     3                                    |             
      Hyperplasia                          |             3                 2        3              2  3     3         |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |    4  3        2  3  3     3  2     3           2                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             3           2                                      4  3      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3                                                                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  M  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  M  M  +|             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Multiple                |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                X         |             
      Pars Distalis, Hyperplasia           |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |             X                                                            |             
      C-Cell, Hyperplasia                  |                                        1                                2|             
      Follicular Cell, Hyperplasia         |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  I  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  M  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                                X                        |             
      Inflammation, Suppurative            | 3  4  4  3                          4  3        2        4        4  4  3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X                                                            |             
      Inflammation, Suppurative            |                2                                2                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                 2                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|             
                             DAY ON TEST   | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|             
                                           | 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                         3|             
      Artery, Inflammation                 |       4           4        4                    4  4  4  4               |             
      Seminiferous Tubule, Atrophy         |                            3                       3                    4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +|             
      Fibrosis                             |                                                                          |             
      Mediastinal, Hemorrhage              |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  +  M  M  M  M  M  +  M  +  +  M  M  +  M  +  M  +  +  M  +|             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                 3                        |             
      Hemorrhage                           |                                                                          |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                4         |             
      Gliosis                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 2                                                                        |             
      Hemorrhage                           |          4                             3                                 |             
      Inflammation, Granulomatous          |          4                                                               |             
      Leukocytosis                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          3           1                                                   |             
      Alveolus, Edema                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|             
                             DAY ON TEST   | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|             
                                           | 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Fibrosis                   |          4           2                                                   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    3  3  4           4                                3                 3|             
      Alveolus, Inflammation, Suppurative  |          3        2  3                          2                        |             
      Artery, Inflammation                 |    4  4        3  4     4  4           4           3                    4|             
      Artery, Mineralization               |    3     4  4  4     3  3  4     3  3     3  2     3     4               |             
      Bronchiole, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                         4|             
      Bronchiole, Inflammation, Suppurative|                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                2                                                         |             
      Inflammation, Suppurative            | 2  3     2     3  1  2     2     2  2  2  2  2  2  3           3  2  2   |             
      Inflammation, Membranous             |                   2                    3                                 |             
      Glands, Dilatation                   |                                           3  2  3  3  2        3        2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Olfactory Epithelium, Degeneration   | 3  3     3  2  1  2  3  3  1  1  2  2  2  1     2  4  2  2  3  3  3  3  1|             
      Olfactory Epithelium, Metaplasia     | 2           1     2  2                                                   |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        | 2  2                                   1           3        1  3  3  3   |             
      Respiratory Epithelium, Hyperplasia  | 1  3     2  2     1  3           2  2  2  1  1  2  2  2  2     2  2  1  1|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 1  3     2  2  2  1  3  1  1  1  2  2  2  1  2  2  2  1  2  1  1  2  2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +  +            |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |          +  +  +     +        +     +     +     +  +  +  +     +         |             
      Inflammation, Chronic                |          3  3  2     3        3     3     3     3  3  2  3     3         |             
      Inflammation, Suppurative            |                                                 3                        |             
      Karyomegaly                          |          3  3  3     3        3     2     3     3  3  3  3     3         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy, Chronic                 | 3  4  4  3  4  3  4  4  4  4  3  3  4  3  4  4  4  4  4  4  3  3  2  3  4|             
      Pelvis, Hemorrhage                   |                                              2                           |             
      Pelvis, Hyperplasia                  |                                              2  3                        |             
      Pelvis, Inflammation, Suppurative    |                                                 3                        |             
      Pelvis, Mineralization               |                   2     3                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|             
                             DAY ON TEST   | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|             
                                           | 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                 2                        |             
      Artery, Inflammation                 |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4|            |
                             DAY ON TEST   | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1|            |
                                           | 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  M  M  +  M  M  M  M  +  +  +  A  +  M  M  A  M  +  M  +  +  M  A  M  M|  21        |
      Parasite Metazoan                    |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  M  A  +  A  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +|  38        |
      Parasite Metazoan                    |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  A  +  +|  42        |
      Parasite Metazoan                    |                3                                                         |      2  3.0|
      Artery, Inflammation                 |                                                                3         |      2  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  A  +  A  A  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +|  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  A  +  A  A  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  A  +  A  A  A  A  +  M  +  A  +  +  +  A  A  +  +  +  +  A  A  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  A  A  +  A  A  A  A  +  A  +  A  +  +  +  A  A  +  +  +  +  A  A  +  A|  27        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     |                         2                                                |      1  2.0|
      Clear Cell Focus                     |                                                                          |      4  2.3|
      Hematopoietic Cell Proliferation     |                                                             3            |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Necrosis                             |       4                                                                  |      3  3.3|
      Bile Duct, Fibrosis                  |                                                          2               |      2  2.5|
      Bile Duct, Hyperplasia               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |          1                 3  2                                          |      6  2.2|
      Inflammation, Chronic                |                                                             4            |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Acinus, Hyperplasia                  |                                                                          |      1  3.0|
      Artery, Inflammation                 |    4                          4                                          |      7  3.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  46        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic                |                                        1  2  2                           |      6  1.7|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
      Karyomegaly                          |          2              2     2     2  2  3  1        1  2               |     23  1.9|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Artery, Inflammation                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  A  +  +  A  +  +  +  +  I  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  43        |
      Acanthosis                           |                         3                                                |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Developmental Malformation           |          X                                                               |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4|            |
                             DAY ON TEST   | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1|            |
                                           | 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |    4                                                                     |      1  4.0|
      Necrosis                             |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       3        2     3                    3                 3           3|     12  2.4|
      Artery, Inflammation                 |                                              4                           |      1  4.0|
      Artery, Mineralization               |    4        4                                                            |      2  4.0|
      Atrium, Thrombosis                   |                                                                      X   |      3     |
      Endocardium, Fibrosis                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hyperplasia                          |          2        3     2     2     3           4     3     3        3   |     15  2.7|
      Inflammation, Chronic                |                                                             3            |      1  3.0|
      Mineralization                       |                                           3                              |      1  3.0|
      Necrosis                             |                                           4                              |      1  4.0|
      Vacuolization Cytoplasmic            |                         2     2     3                    3  3            |     14  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  A  +  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |    3                          2  2           1     2     3  3            |     11  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  M  +  M  I  +  +  +  M  M  M  +  +  M  +  +  +  +  +  M  M  +|  30        |
      Hyperplasia                          |    4                                                                     |      1  4.0|
      Hyperplasia, Multiple                |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  A  I  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Pars Distalis, Cyst                  |                               X           X                              |      3     |
      Pars Distalis, Hyperplasia           |                                     2                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Ultimobranchial Cyst                 |                         X                                                |      2     |
      C-Cell, Hyperplasia                  |          2           2                 1           1     3               |      7  1.7|
      Follicular Cell, Hyperplasia         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4|            |
                             DAY ON TEST   | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1|            |
                                           | 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                                          |      2     |
      Inflammation, Suppurative            |                   3     3  2     4  4  4  4        4     4  2     4  2   |     23  3.4|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Suppurative            |                                                             4        3   |      4  2.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                    4                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |          3                       3     3  4        2                     |      6  3.0|
      Artery, Inflammation                 |    4                          4           4                              |     10  4.0|
      Seminiferous Tubule, Atrophy         |          4     3                          4                              |      6  3.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|  44        |
      Fibrosis                             |                                                                      3   |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  A  M  +  +  +  M  +  +  M  +  +  M  +  +  +  M  +  +  M  +  M|  29        |
      Inflammation, Granulomatous          |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  A  +  M  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  M|  40        |
      Hyperplasia, Lymphoid                |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                     3  3                    4            |      4  3.3|
      Hemorrhage                           |                                                    4  4                  |      2  4.0|
      Infarct                              |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  A  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                 4                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4|            |
                             DAY ON TEST   | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1|            |
                                           | 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1  4.0|
      Gliosis                              |                                                                   3      |      1  3.0|
      Hemorrhage                           |                                                    3  3                  |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  A  A  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  45        |
      Inflammation, Suppurative            |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Foreign Body                         |                                                                          |      1  2.0|
      Hemorrhage                           |    4                                      3        3  3              4   |      7  3.4|
      Inflammation, Granulomatous          |                               2     3                                    |      3  3.0|
      Leukocytosis                         |                                                             4            |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                         1                 2              4           1   |      6  2.0|
      Alveolus, Edema                      |                            3                                         4   |      2  3.5|
      Alveolus, Fibrosis                   |                                           2                          3   |      4  2.8|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    4           3        3     3        2  4              3  2  1     4  3|     17  3.1|
      Alveolus, Inflammation, Suppurative  |                                           2                              |      5  2.4|
      Artery, Inflammation                 |                      4                                      4  4         |     12  3.8|
      Artery, Mineralization               |          3        4  4        3                 3        4     4  4     3|     22  3.4|
      Bronchiole, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  4.0|
      Bronchiole, Inflammation, Suppurative|                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
      Foreign Body                         |          3                       3                                       |      3  2.7|
      Inflammation, Suppurative            |          2        2     2        2  3     2     1           2        3  1|     27  2.1|
      Inflammation, Membranous             |                         3        2                                       |      4  2.5|
      Glands, Dilatation                   | 2        2              3     2     2  2  2        2  2  2  1     3  2   |     20  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |          2              1                                            3   |      3  2.0|
      Olfactory Epithelium, Degeneration   | 2     3  3     2  2  3  2  2  2  2  3  3  3  2  2  2  2  2  3     2  3  2|     45  2.3|
      Olfactory Epithelium, Metaplasia     |                         2        2                                       |      6  1.8|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Squamous                        |       1              2  1     1        1  2        1  1     3     1  2   |     19  1.8|
      Respiratory Epithelium, Hyperplasia  | 1     1        1     2  1        1     1  2  2  2     1           1  3  2|     33  1.7|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 2     2  2     1     1  1     1  1  1  2  2  2  2     1     1        2   |     40  1.6|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  45        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4|            |
                             DAY ON TEST   | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1|            |
                                           | 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |          +              +     +  +  +        +           +  +     +      |  21        |
      Inflammation, Chronic                |          3              3     3  3  3        3           3  2     3      |     21  2.9|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Karyomegaly                          |          3              3     3  3  2        4           3  3     3      |     21  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                     X                                    |      1     |
      Nephropathy, Chronic                 | 2  4  4  4     4  3  4  4  4  4  4  4  3  4  4  4  4  3  3  4  4  4  4  3|     49  3.6|
      Pelvis, Hemorrhage                   |                                                                          |      1  2.0|
      Pelvis, Hyperplasia                  |                                                                          |      2  2.5|
      Pelvis, Inflammation, Suppurative    |                                                             4            |      2  3.5|
      Pelvis, Mineralization               |                                              3                           |      3  2.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                             4            |      2  3.0|
      Artery, Inflammation                 |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|             
                             DAY ON TEST   | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|             
                                           | 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  M  M  M  M  M  +  M  M  +  +  M  +  A  +  A  +  A  M  +  A  +  M  M  M|             
      Parasite Metazoan                    |                   X                                      X               |             
      Artery, Inflammation                 |                                     4                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  A|             
      Parasite Metazoan                    |    X                                                                 X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  A  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  A  +  A  A  +  +  +  A  +  +  +  +  M  +  +  +  A  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  A  +  A  A  A  +  A  +  +  A  +  +  A  +  A  +  A  M  +  A  +  A  +  A|             
      Artery, Inflammation                 |                                  4                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  +  A  A  A  +  A  +  +  A  +  +  A  +  +  +  A  +  +  A  +  A  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Angiectasis                          |                                                          2               |             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |                      4                                                   |             
      Bile Duct, Cyst                      | X                                                                        |             
      Bile Duct, Fibrosis                  |                2     2        3                 2                        |             
      Bile Duct, Hyperplasia               |                               2                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Artery, Inflammation                 |                      4                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Atrophy                              |                                                                          |             
      Fibrosis                             |                                           4                              |             
      Hemorrhage                           |                                                                          |             
      Infarct                              |                                  4                                       |             
      Acinus, Hyperplasia                  |                                                                          |             
      Artery, Inflammation                 |                      3     4        4     4     3        4               |             
      Artery, Thrombosis                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M|             
      Inflammation, Chronic                |    2                       2  2              2                           |             
      Karyomegaly                          |                   1  2  2  2  2  2  2  3  2  2  1                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Suppurative            |                                  3                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|             
                             DAY ON TEST   | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|             
                                           | 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                          |             
      Artery, Inflammation                 |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2     3  1                    2  4  2  2              3            |             
      Inflammation, Suppurative            |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
      Artery, Mineralization               | 3                             3                                          |             
      Atrium, Thrombosis                   | X           X              X  X  X                                       |             
      Endocardium, Fibrosis                |                                                    4                     |             
      Myocardium, Hemorrhage               |                                                                      2   |             
      Ventricle, Thrombosis                |             X                                                            |             
      Ventricle Right, Dilatation          |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        3        2  2        3  3         |             
      Hypertrophy                          |                                                                3         |             
      Infarct                              |                                                                          |             
      Necrosis                             |                      4                                                   |             
      Vacuolization Cytoplasmic            |                               3        3  2     3     3  2  3     2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                               2                                          |             
      Hyperplasia                          |             2  3                                3                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  M  +|             
      Hyperplasia                          |                                           3                              |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                    X                 X   |             
      Pars Distalis, Hyperplasia           |                                  3              2                        |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Ultimobranchial Cyst                 |                   X                                                      |             
      C-Cell, Hyperplasia                  |                   4        4     2                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  I  +  M|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|             
                             DAY ON TEST   | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|             
                                           | 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                   X                                                      |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                3  3                    3  4     2              4     2   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation, Suppurative            |       3                       4           4                              |             
      Mineralization                       |                                  4                                       |             
      Artery, Inflammation                 |                                                             3            |             
      Epithelium, Hyperplasia              |                                           2                              |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +|             
      Inflammation, Suppurative            |       3                       4           4                              |             
      Artery, Inflammation                 |                                           4                              |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                  4                                       |             
      Mineralization                       | 4                             4                    4                     |             
      Artery, Inflammation                 |                      4     3        4  4  4     2        4  4            |             
      Seminiferous Tubule, Atrophy         |                               4                    4                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                            +                                             |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  A  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  M|             
      Hemorrhage                           |                            4  3                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  A  M  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  A  +  M|             
      Hemorrhage                           |                                              3                           |             
      Hyperplasia, Lymphoid                |       2                                                  2               |             
      Inflammation, Suppurative            |                   1        2                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                  4                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            3                                             |             
      Thrombosis                           |                            X                                             |             
      Artery, Inflammation                 |                4                          3                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteoporosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|             
                             DAY ON TEST   | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|             
                                           | 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      4   |             
      Necrosis                             |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation, Chronic                |                                           2                              |             
      Inflammation, Suppurative            |                                              2                           |             
      Artery, Inflammation                 |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hemorrhage                           | 2                             2                                          |             
      Inflammation, Granulomatous          |                                     2                                    |             
      Alveolar Epithelium, Hyperplasia     |                            2                    1                    1   |             
      Alveolus, Edema                      |                      1                                                   |             
      Alveolus, Fibrosis                   |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                3  2        3  3     2  3  3     2                    1   |             
      Alveolus, Inflammation, Suppurative  | 2                          2  2                                      3   |             
      Alveolus, Mineralization             |                                  3                                       |             
      Artery, Inflammation                 |                                  4  4  4  4              4               |             
      Artery, Mineralization               |    3           3  2                          3  2  3     3  4            |             
      Bronchiole, Inflammation, Suppurative|                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Foreign Body                         |                                           2                              |             
      Inflammation, Suppurative            | 1              1  2  3        2  3        4  1              2  2         |             
      Inflammation, Membranous             |                                     1                          2         |             
      Glands, Dilatation                   | 2                 2           1  1        1  1        1        2     1  1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                           3           2                  |             
      Olfactory Epithelium, Degeneration   | 3  2  3     2  2  3  3  2  2  3  4  3  3  3  2  3  2  4  2  3  2     4  3|             
      Olfactory Epithelium, Metaplasia     |                                     1           1     1                  |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        | 2     2           2  2  1     1  1  1  2  2  1  1     1  1           2  2|             
      Respiratory Epithelium, Hyperplasia  | 2  2                 3  3  2  2  4        4  2     2        1  1     3  3|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 3  3        1  1  2  2  2  3  3  4  2  2  4  1  1     1  1  2  2     3  3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|             
                             DAY ON TEST   | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|             
                                           | 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cataract                             |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +  +  +            |             
      Inflammation, Chronic                |                                                       2  3  2            |             
      Karyomegaly                          |                                                       3  3               |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |       M           +                 +  +  +                    +         |             
      Hyperplasia                          |                   3                                                      |             
      Inflammation, Chronic                |                   3                 3  3  3                    3         |             
      Karyomegaly                          |                   4                 3  3  4                    3         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Cyst                                 | X                                                           X            |             
      Nephropathy, Chronic                 | 3  3  3     3  4  4  4  3  4  4  4  4  4  4  3  4  4  3  4  4  4     3  4|             
      Glomerulus, Mineralization           |                                                                          |             
      Pelvis, Hyperplasia                  |                                           3                              |             
      Pelvis, Inflammation, Suppurative    |                                           4                              |             
      Pelvis, Mineralization               |                                              3                           |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                               3           4                              |             
      Inflammation, Suppurative            |                               2           3                          3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5|            |
                             DAY ON TEST   | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2|            |
                                           | 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  A  A  +  +  A  +  A  A  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  M  +  M  M  A  +  M  M  M  A  A  +  M  +  M  M  +  +  M  +  M  A  M  M|  15        |
      Parasite Metazoan                    |                                                                          |      2     |
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  A  +  +  A  A  +  A  +  +  +  +  +  +  +  A  A  +  +  A  +  A  A  +  +|  34        |
      Parasite Metazoan                    |                            2  X                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  M  A  +  +  A  +  A  A  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  +  +  A  A  +  +  +  +  A  +  +  +  +  A  A  +  +  A  +  A  A  +  +|  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  A  A  +  +  +  +  A  +  +  +  +  A  A  +  +  A  +  A  A  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  A  +  +  M  A  +  A  +  A  A  A  +  +  +  A  A  +  +  A  +  A  A  +  +|  23        |
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  A  +  +  A  A  +  A  +  A  A  +  +  +  +  A  A  A  +  A  +  A  A  +  +|  25        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
      Angiectasis                          |                                           2                              |      2  2.0|
      Clear Cell Focus                     |                                           2                 3        1   |      3  2.0|
      Hematopoietic Cell Proliferation     |                                                       2                  |      1  2.0|
      Necrosis                             |                            4                                             |      2  4.0|
      Bile Duct, Cyst                      |                                                                          |      1     |
      Bile Duct, Fibrosis                  |                            2                          2                  |      6  2.2|
      Bile Duct, Hyperplasia               |                   2                                                      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +|  44        |
      Atrophy                              |                         3        2                                       |      2  2.5|
      Fibrosis                             |                                                                          |      1  4.0|
      Hemorrhage                           |                                           3                              |      1  3.0|
      Infarct                              |                                                                          |      1  4.0|
      Acinus, Hyperplasia                  |                               2           2                              |      2  2.0|
      Artery, Inflammation                 |                               4                       4              4   |      9  3.8|
      Artery, Thrombosis                   |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic                |             2                                                            |      5  2.0|
      Karyomegaly                          | 1  1              2              2  1     2           2     2           1|     20  1.8|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  44        |
      Hyperkeratosis                       |                                              4                           |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5|            |
                             DAY ON TEST   | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2|            |
                                           | 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                              X                           |      1     |
      Hemorrhage                           |                                        1                                 |      1  1.0|
      Hyperplasia                          |          3                                                               |      1  3.0|
      Inflammation, Necrotizing            |                                        3                                 |      1  3.0|
      Mineralization                       |                                                          4               |      1  4.0|
      Necrosis                             |          4                                                               |      1  4.0|
      Artery, Inflammation                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    4                 2        2  2              3     2  3  2  3  3     2|     19  2.5|
      Inflammation, Suppurative            |                            3                       4                     |      2  3.5|
      Artery, Inflammation                 |                                                 4                        |      1  4.0|
      Artery, Mineralization               |                                                                          |      2  3.0|
      Atrium, Thrombosis                   |                   X                                X  X                  |      8     |
      Endocardium, Fibrosis                |                                                                          |      1  4.0|
      Myocardium, Hemorrhage               |                                                                          |      1  2.0|
      Ventricle, Thrombosis                |                                                                          |      1     |
      Ventricle Right, Dilatation          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                   2        3  2  1        4              2     3  3      |     13  2.5|
      Hypertrophy                          |                                                                          |      1  3.0|
      Infarct                              |                                                                      4   |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            |       3  3              3        1  4     3        3  3     3            |     17  2.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia                          |          3        3     3              4           3  3        2         |     10  2.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|  45        |
      Hyperplasia                          |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  M  M  M  +  +  M  +  M  +  +  +  +  +  +|  38        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  A  +  +  +  +  +  +  +  I  +  +  +  +  +  A  M  A  +  +  +|  44        |
      Pars Distalis, Cyst                  |       X                                                                  |      3     |
      Pars Distalis, Hyperplasia           |       3           3                                                      |      4  2.8|
      Pars Intermedia, Hyperplasia         |          3                                                               |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5|            |
                             DAY ON TEST   | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2|            |
                                           | 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Ultimobranchial Cyst                 |                                                 X                       X|      3     |
      C-Cell, Hyperplasia                  |                         3                          2  3              1   |      7  2.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  I  M  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
      Cyst                                 |       X                                                                  |      2     |
      Hyperplasia                          |                                                                         3|      1  3.0|
      Inflammation, Suppurative            |                   3           4  4        4  4        3  3     3         |     15  3.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Suppurative            |                   4                                                      |      4  3.8|
      Mineralization                       |                                                                          |      1  4.0|
      Artery, Inflammation                 |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  45        |
      Inflammation, Suppurative            |                   4                                                      |      4  3.8|
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Infarct                              |                                                                          |      1  4.0|
      Mineralization                       |       2                                   3              3        4      |      7  3.4|
      Artery, Inflammation                 |                               4                       4              4   |     11  3.7|
      Seminiferous Tubule, Atrophy         |                                           4                              |      3  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  A  +  +  +|  44        |
      Fibrosis                             |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  M  M  +|  38        |
      Hemorrhage                           |                                  2              4     3                  |      6  3.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  42        |
      Hemorrhage                           |       2                                               4                  |      3  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|  46        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5|            |
                             DAY ON TEST   | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2|            |
                                           | 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     | 3                                                                        |      1  3.0|
      Infarct                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  A  +  +  +  +  +  M  +  +|  44        |
      Hemorrhage                           |                                                       3                  |      2  3.0|
      Thrombosis                           |                                                                          |      1     |
      Artery, Inflammation                 |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  M  +  M  +  +  M  M  M  +|  32        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Osteoporosis                         |                                                          3               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           | 3        4                                                               |      3  3.7|
      Necrosis                             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +|  43        |
      Inflammation, Chronic                |                                                             2            |      2  2.0|
      Inflammation, Suppurative            | 1                                                                        |      2  1.5|
      Artery, Inflammation                 |                               4                                          |      1  4.0|
      Epithelium, Hyperplasia              |             2                             2                              |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +|  45        |
      Hemorrhage                           | 3        3                 2           3           3                 4   |      8  2.8|
      Inflammation, Granulomatous          |                                                             3            |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |                                                       1              1   |      5  1.2|
      Alveolus, Edema                      |          3                                                               |      2  2.0|
      Alveolus, Fibrosis                   |                                                       2              2   |      2  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                   2     2        3  3  2           3  4     2  3     4   |     19  2.6|
      Alveolus, Inflammation, Suppurative  | 2                                                     3              3   |      7  2.4|
      Alveolus, Mineralization             |                                                                          |      1  3.0|
      Artery, Inflammation                 |                                                       4                  |      6  4.0|
      Artery, Mineralization               |                   3     3  3     3        3  3              3  4         |     16  3.0|
      Bronchiole, Inflammation, Suppurative|                                                                      4   |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5|            |
                             DAY ON TEST   | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2|            |
                                           | 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  A  +  A  +  +  +|  43        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                   3           4  2     3  2        2  2              3   |     18  2.3|
      Inflammation, Membranous             |    2  2                 2              2  2                              |      7  1.9|
      Glands, Dilatation                   |       1     1     2     1        1  2  1  2                 1        1  2|     21  1.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |    3              2                    2           2  2     3           1|      9  2.2|
      Olfactory Epithelium, Degeneration   | 3  3  3  3  3     3  3  3  3  3  2  3  3  3        3  3     2     2  3  3|     43  2.8|
      Olfactory Epithelium, Metaplasia     |       2                 1        1        2                          1  3|      9  1.4|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Squamous                        |    2  2  3  2     2  2  2  2  2  2  1  1  2        2  2     1     1  2  3|     35  1.7|
      Respiratory Epithelium, Hyperplasia  | 2  2     3  3     3     2  1  1  2  2  3           3  4           2  3  3|     30  2.4|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 2  2     2  3     2     2  1  1  2  2  3           3  3     1     2  3  3|     38  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +|  42        |
      Inflammation, Chronic                |                                        2  2                              |      2  2.0|
      Artery, Inflammation                 |       4                                                                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +  +                                 |   2        |
      Cataract                             |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +     +     +     +     +                                    |   8        |
      Inflammation, Chronic                |             3     3     3     3     3                                    |      8  2.8|
      Karyomegaly                          |             4     4     3     3     4                                    |      7  3.4|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                    +           +         |   7        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                    4           4         |      7  3.3|
      Karyomegaly                          |                                                    3           3         |      7  3.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                                          |      2     |
      Nephropathy, Chronic                 | 2  3  4  3  4  4  4  4  3  4  4  4  4  3  4  4     4  4  4  4  4  4  4  3|     47  3.7|
      Glomerulus, Mineralization           | 3                                                                        |      1  3.0|
      Pelvis, Hyperplasia                  |             2                                                            |      2  2.5|
      Pelvis, Inflammation, Suppurative    |             3     3                                                      |      3  3.3|
      Pelvis, Mineralization               |                   1                                                      |      2  2.0|
      Renal Tubule, Mineralization         | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|  44        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05080-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:33:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5|            |
                             DAY ON TEST   | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2|            |
                                           | 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           | 4                                                                        |      1  4.0|
      Hyperplasia                          |                   3                                                      |      3  3.3|
      Inflammation, Suppurative            |                   3                                                      |      4  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
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