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TDMS Study 05080-01 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Northwest                                        DATE: 09/10/94   
EXP: 05080                   ALLYL GLYCIDYL ETHER              TIME: 19:04:03   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 56666    
CONT: N01ES38061                                               CAS: 106-92-3    
PATHOLOGIST: R. RENNE                                                           
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Northwest                                        DATE: 09/10/94  
EXP: 05080                   ALLYL GLYCIDYL ETHER              TIME: 19:04:03  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 56666   
CONT: N01ES38061                                               CAS: 106-92-3   
PATHOLOGIST: R. RENNE                                                          

                               ALLYL GLYCIDYL ETHER


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 737 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 38     CENSORED DEATHS 0    TERMINAL 12        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      327   372   402   445   449   477   479   485   506   548                 |
 |      548   564   578   579   586   590   593   599   604   607                 |
 |      609   635   642   657   658   661   666   683   684   690                 |
 |      698   710   719   719   723   731   733   735                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 39     CENSORED DEATHS 0    TERMINAL 11        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      231   413   443   444   466   475   499   500   520   521                 |
 |      526   531   554   560   565   578   579   586   591   599                 |
 |      606   624   626   635   638   638   650   655   659   662                 |
 |      668   670   677   683   683   689   704   708   722                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 42     CENSORED DEATHS 0    TERMINAL 8         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      108   264   282   300   303   434   482   520   523   524                 |
 |      537   559   568   570   574   579   580   585   586   588                 |
 |      590   592   593   599   600   605   610   617   628   634                 |
 |      642   642   652   653   662   666   674   678   681   694                 |
 |      701   730                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                               ALLYL GLYCIDYL ETHER


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 737 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   737 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0  98.0  94.0  84.0  82.0  62.0  48.0  24.0      |
 |           |                                                                    |
 |           |                                                                    |
 |5 PPM      |   100.0 100.0  98.0  98.0  96.0  88.0  76.0  60.0  40.0  22.0      |
 |           |                                                                    |
 |           |                                                                    |
 |10 PPM     |   100.0  98.0  96.0  90.0  90.0  86.0  78.0  48.0  30.0  16.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          5 PPM            10 PPM        |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       24.0%            22.0%            16.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.124          P=0.592          P=0.138       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       597.1            584.1            562.1         |
 |NATURAL DEATHS (C)      |       (17.5)           (16.1)           (20.4)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       630.7            617.7            590.1         |
 |(STANDARD ERROR)        |       (15.8)           (15.5)           (19.4)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                               ALLYL GLYCIDYL ETHER


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 737 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      207   269   474   478   521   537   541   569   579   579                 |
 |      600   611   638   647   667   678   683   690   705   705                 |
 |      705   722   723   723   734   736                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 20     CENSORED DEATHS 0    TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      164   318   339   396   408   471   547   550   569   579                 |
 |      579   631   642   642   659   669   674   720   723   735                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 25     CENSORED DEATHS 0    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      31    220   269   281   330   332   367   409   570   570                 |
 |      578   579   624   624   648   652   658   668   694   694                 |
 |      705   715   729   729   733                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                               ALLYL GLYCIDYL ETHER


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 737 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   737 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0  96.0  96.0  96.0  92.0  86.0  78.0  72.0  48.0      |
 |           |                                                                    |
 |           |                                                                    |
 |5 PPM      |   100.0  98.0  98.0  94.0  90.0  88.0  88.0  78.0  70.0  60.0      |
 |           |                                                                    |
 |           |                                                                    |
 |10 PPM     |    98.0  98.0  94.0  88.0  84.0  84.0  84.0  76.0  66.0  50.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          5 PPM            10 PPM        |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       48.0%            60.0%            50.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=1.000          P=0.428N         P=1.000N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       604.7            550.8            536.4         |
 |NATURAL DEATHS (C)      |       (26.4)           (34.7)           (39.2)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       668.2            662.5            636.7         |
 |(STANDARD ERROR)        |       (16.6)           (18.9)           (24.1)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                        ALLYL GLYCIDYL ETHER
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        5 PPM            = 2
                                                        10 PPM           = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  112 +
      |
      |
      | 1                 3                 2     3         1      1     2
P  96 +                                           3  3 3           1    12    1
E     |                                                33                   3 1 1 221
R     |                                                                     3      211 2   3
C     |                                                                              1 21  2   1
E  80 +                                                                                    223 131
N     |                                                                                     2   2131
T     |                                                                                         22311 1
      |                                                                                            22 11
S  64 +                                                                                             2 211
U     |                                                                                             3 321  21
R     |                                                                                               33   211 1
V     |                                                                                                33   22 1 1
I  48 +                                                                                                 333  222 11 1
V     |                                                                                                   333  2 2  11
A     |                                                                                                     33   22  11 1
L     |                                                                                                      3 3  222   11
   32 +                                                                                                        3 33 22   11 1
      |                                                                                                           33 2 22
      |                                                                                                            33 3 2 2 11
      |                                                                                                               33    3
   16 +                                                                                                                     33
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 43 obs hidden.

                                                        ALLYL GLYCIDYL ETHER
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        5 PPM            = 2
                                                        10 PPM           = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1     3                   2      1
      |       3                   2      1 3       1       2
      |                                    3       1 3     2  2        2           11
      |                                              3       3         2 2          1      1
P  90 +                                                                  2         2       1 1
E     |                                                      3    3                2         112
R     |                                                           3      3                    12  11
C     |                                                                                           22
E  80 +                                                                                           31   1
N     |                                                                                            2   1 1  2
T     |                                                                                            3     1 3211
      |                                                                                                    3 21  21
S  70 +                                                                                                       33 211
U     |                                                                                                           211
R     |                                                                                                        3  321131 22
V     |                                                                                                                   2 2
I  60 +                                                                                                               33    22
V     |                                                                                                                1 31
A     |                                                                                                                  3  3
L     |                                                                                                                   1 1
   50 +                                                                                                                     11
      |                                                                                                                      1
      |
      |
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 22 obs hidden.

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