National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3517

TDMS Study 05084-02 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         TURMERIC OLEORESIN


NTP Experiment-Test: 05084-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: DOSED FEED                                                                                                 Time: 00:23:05




       Facility:  TSI Mason Research

       Chemical CAS #:  458-37-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05084-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10            9           10                                     
  Early Deaths                                                                                                                      
    Dead                                               3            2            7            1                                     
    Moribund                                           7            7           10            7                                     
    Accident                                           1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           40           34           41                                     
    Dead                                               1                                      1                                     
    Moribund                                           1            1                                                               
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (55)         (48)         (46)         (57)                                   
      Histiocytic Sarcoma, Metastatic                               1 (2%)                                                          
   Intestine Large, Cecum                             (59)         (60)         (59)         (60)                                   
      Leiomyoma                                                                               1 (2%)                                
   Intestine Small, Duodenum                          (60)         (60)         (57)         (60)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Small, Ileum                             (60)         (60)         (58)         (59)                                   
   Intestine Small, Jejunum                           (60)         (60)         (57)         (60)                                   
   Liver                                              (60)         (52)         (56)         (60)                                   
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (2%)                                
      Hepatocellular Carcinoma                         7 (12%)      5 (10%)      8 (14%)      5 (8%)                                
      Hepatocellular Carcinoma, Multiple                                         2 (4%)       2 (3%)                                
      Hepatocellular Adenoma                           7 (12%)      5 (10%)     11 (20%)      8 (13%)                               
      Hepatocellular Adenoma, Multiple                              3 (6%)       9 (16%)      6 (10%)                               
      Histiocytic Sarcoma, Metastatic                               2 (4%)                    1 (2%)                                
   Pancreas                                           (60)         (50)         (49)         (60)                                   
   Salivary Glands                                    (60)         (50)         (51)         (60)                                   
   Stomach, Forestomach                               (59)         (60)         (59)         (59)                                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                                                    1 (2%)       3 (5%)                                
   Stomach, Glandular                                 (60)         (60)         (59)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05084-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (50)         (51)         (60)                                   
      Histiocytic Sarcoma, Metastatic                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (51)         (51)         (59)                                   
      Adenoma                                                       1 (2%)                                                          
   Adrenal Gland, Medulla                             (60)         (45)         (40)         (55)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
   Islets, Pancreatic                                 (60)         (50)         (49)         (57)                                   
      Adenoma                                                                                 1 (2%)                                
   Parathyroid Gland                                  (39)         (39)         (32)         (30)                                   
   Pituitary Gland                                    (56)         (49)         (50)         (59)                                   
      Pars Distalis, Adenoma                                        2 (4%)       4 (8%)       5 (8%)                                
   Thyroid Gland                                      (60)         (50)         (50)         (59)                                   
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (60)         (51)         (50)         (58)                                   
      Cystadenoma                                      1 (2%)       2 (4%)       1 (2%)                                             
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Hemangioma                                                    1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic                               1 (2%)                                                          
      Luteoma                                                                                 1 (2%)                                
   Uterus                                             (60)         (54)         (53)         (60)                                   
      Histiocytic Sarcoma                                           2 (4%)       2 (4%)       3 (5%)                                
      Polyp Stromal                                    1 (2%)       1 (2%)                                                          
      Sarcoma Stromal                                  1 (2%)                                                                       
      Cervix, Basosquamous Tumor Malignant                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (50)         (50)         (60)                                   
      Sternal, Histiocytic Sarcoma, Metastatic                      2 (4%)                                                          
   Lymph Node                                         (57)         (47)         (48)         (60)                                   
      Lumbar, Histiocytic Sarcoma, Metastatic                                                 1 (2%)                                
      Mediastinal, Histiocytic Sarcoma, Metastatic                  1 (2%)                                                          
                                                             Page   3                                                               
NTP Experiment-Test: 05084-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Renal, Histiocytic Sarcoma, Metastatic                                                  1 (2%)                                
   Lymph Node, Mesenteric                             (58)         (46)         (47)         (59)                                   
      Histiocytic Sarcoma, Metastatic                               1 (2%)                                                          
   Spleen                                             (59)         (51)         (50)         (60)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
   Thymus                                             (53)         (43)         (45)         (56)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (54)         (48)         (49)         (57)                                   
      Adenocarcinoma                                                1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)                                                          
   Skin                                               (60)         (52)         (55)         (59)                                   
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (50)         (51)         (59)                                   
      Chordoma                                                      1 (2%)                                                          
   Skeletal Muscle                                    (1)                       (1)          (2)                                    
      Sarcoma                                                                    1 (100%)                                           
      Back, Adenocarcinoma, Metastatic, Uncertain                                                                                   
          Primary Site                                 1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (51)         (60)                                   
      Meninges, Sarcoma                                1 (2%)                                 1 (2%)                                
      Meninges, Schwannoma Malignant, Metastatic                                              1 (2%)                                
   Peripheral Nerve                                                                          (1)                                    
      Schwannoma Malignant                                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (50)         (52)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     4 (7%)       3 (6%)       4 (8%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      2 (3%)       1 (2%)       3 (6%)       2 (3%)                                
      Histiocytic Sarcoma, Metastatic                               2 (4%)                                                          
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
   Nose                                               (60)         (50)         (50)         (60)                                   
      Histiocytic Sarcoma, Metastatic                               1 (2%)                                                          
                                                             Page   4                                                               
NTP Experiment-Test: 05084-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
   Trachea                                            (60)         (50)         (51)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (2)                       (1)                                    
      Adenoma                                                       2 (100%)                  1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (50)         (51)         (60)                                   
      Histiocytic Sarcoma, Metastatic                               1 (2%)                                                          
   Urinary Bladder                                    (60)         (50)         (50)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                                           2 (3%)       2 (3%)       3 (5%)                                
      Lymphoma Malignant Histiocytic                                             1 (2%)                                             
      Lymphoma Malignant Lymphocytic                                1 (2%)                                                          
      Lymphoma Malignant Mixed                         9 (15%)     13 (22%)     12 (20%)      7 (12%)                               
      Lymphoma Malignant Undifferentiated Cell                      2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05084-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            31          33          37          34                                       
     Total Primary Neoplasms                           38          48          64          47                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 14          18          24          21                                       
     Total Benign Neoplasms                            16          21          32          27                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          25          23          17                                       
     Total Malignant Neoplasms                         22          27          32          20                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           3           4           4                                       
     Total Metastatic Neoplasm                          3          14           4           7                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05084-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                           5            6            8            6                                     
    Dead                                               2            1            5            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                43           42           37           42                                     
    Dead                                                            1                                                               
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (53)         (47)         (48)         (55)                                   
   Intestine Large, Cecum                             (60)         (60)         (60)         (60)                                   
   Intestine Small, Duodenum                          (60)         (59)         (60)         (60)                                   
      Adenocarcinoma                                                             1 (2%)                                             
   Intestine Small, Ileum                             (60)         (60)         (60)         (60)                                   
      Adenocarcinoma                                                1 (2%)                                                          
   Intestine Small, Jejunum                           (60)         (60)         (60)         (60)                                   
      Adenocarcinoma                                                2 (3%)       2 (3%)                                             
   Liver                                              (60)         (59)         (60)         (60)                                   
      Hemangiosarcoma                                  1 (2%)       3 (5%)       1 (2%)       1 (2%)                                
      Hepatoblastoma                                                             3 (5%)       1 (2%)                                
      Hepatocellular Carcinoma                        12 (20%)     15 (25%)     14 (23%)     13 (22%)                               
      Hepatocellular Carcinoma, Multiple                            3 (5%)       4 (7%)       5 (8%)                                
      Hepatocellular Adenoma                          16 (27%)     12 (20%)     13 (22%)     12 (20%)                               
      Hepatocellular Adenoma, Multiple                 9 (15%)     17 (29%)     24 (40%)     19 (32%)                               
   Pancreas                                           (60)         (50)         (50)         (59)                                   
   Stomach, Forestomach                               (60)         (59)         (60)         (60)                                   
      Squamous Cell Papilloma                          2 (3%)                                                                       
   Tongue                                             (1)          (1)                                                              
      Squamous Cell Carcinoma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (50)         (51)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05084-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (50)         (50)         (59)                                   
      Adenoma                                          1 (2%)                                 1 (2%)                                
   Adrenal Gland, Medulla                             (60)         (42)         (43)         (59)                                   
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Islets, Pancreatic                                 (60)         (50)         (50)         (59)                                   
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Pituitary Gland                                    (60)         (49)         (50)         (60)                                   
   Thyroid Gland                                      (60)         (49)         (49)         (60)                                   
      Adenocarcinoma                                                             1 (2%)                                             
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)                    2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (50)         (50)         (60)                                   
   Preputial Gland                                    (25)         (24)         (29)         (31)                                   
   Prostate                                           (60)         (50)         (50)         (60)                                   
   Seminal Vesicle                                    (50)         (51)         (50)         (49)                                   
   Testes                                             (60)         (50)         (50)         (60)                                   
      Sertoli Cell, Adenoma                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (50)         (49)         (60)                                   
   Lymph Node                                         (57)         (51)         (46)         (57)                                   
   Lymph Node, Mesenteric                             (56)         (50)         (46)         (56)                                   
   Spleen                                             (60)         (50)         (52)         (59)                                   
      Hemangiosarcoma                                               1 (2%)       1 (2%)       1 (2%)                                
   Thymus                                             (48)         (47)         (42)         (46)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (58)         (47)         (51)         (60)                                   
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Subcutaneous Tissue, Hemangioma                                            2 (4%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05084-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (1)                                                 
      Sarcoma                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (49)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (50)         (50)         (60)                                   
      Adenocarcinoma, Metastatic, Harderian Gland                   1 (2%)                                                          
      Alveolar/Bronchiolar Adenoma                     7 (12%)      8 (16%)      6 (12%)     10 (17%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           4 (7%)       1 (2%)       1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   4 (7%)       6 (12%)                   4 (7%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      2 (3%)       2 (4%)       5 (10%)      3 (5%)                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Mediastinum, Hemangioma                                       1 (2%)                                                          
   Nose                                               (58)         (49)         (50)         (60)                                   
      Adenocarcinoma, Metastatic, Harderian Gland                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)          (1)                       (1)                                    
      Fibrosarcoma                                     1 (50%)                                                                      
   Harderian Gland                                    (4)          (4)          (1)          (6)                                    
      Adenocarcinoma                                                1 (25%)                                                         
      Adenoma                                          4 (100%)     3 (75%)      1 (100%)     5 (83%)                               
      Bilateral, Adenoma                                                                      1 (17%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (53)         (50)         (60)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Renal Tubule, Adenoma                            1 (2%)                                                                       
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
   Urinary Bladder                                    (60)         (50)         (50)         (60)                                   
                                                             Page   9                                                               
NTP Experiment-Test: 05084-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Lymphoma Malignant Histiocytic                   1 (2%)                                                                       
      Lymphoma Malignant Mixed                                      3 (5%)       2 (3%)       7 (12%)                               
      Lymphoma Malignant Undifferentiated Cell                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05084-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          43          51          45                                       
     Total Primary Neoplasms                           67          82          81          86                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 34          33          42          37                                       
     Total Benign Neoplasms                            46          44          49          52                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          28          27          30                                       
     Total Malignant Neoplasms                         21          38          32          34                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           4           5           3                                       
     Total Metastatic Neoplasm                          2           5           5           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.