TDMS Study 05084-02 Pathology Tables
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 Facility: TSI Mason Research Chemical CAS #: 8024-37-1 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 4| 7| 5| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 3| 2| 5| 3| 3| 3| 8| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 5| 2| 3| 3| 3| 5| | 1| 3| 1| 2| 0| 1| 0| 1| 6| 1| 0| 1| 1| 1| 1| 1| 3| 1| 1| 0| 8| 1| 1| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + M + M + + + + + + + + + + + + + + + + + M +| Autolysis | 3 | Inflammation, Chronic | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 4 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 3 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 2 1 | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 4 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 4 | Hyperplasia, Lymphoid | | Peyer's Patch, Hyperplasia | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 4 | Hyperplasia, Lymphoid | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Autolysis | | Clear Cell Focus | 1 2 2 2| Eosinophilic Focus | 1 | Fatty Change | | Fibrosis | 2 | Hematopoietic Cell Proliferation | | Inflammation, Acute | | Inflammation, Chronic Active | 1 1 1 3 1 1 1 1 1 1 1 1 1 | Mixed Cell Focus | 1 | Necrosis, Coagulative | | Necrosis | | Oval Cell, Hyperplasia | | __________________________________________________________________________| Mesentery | + + + | Fibrosis | 2 1 2 | Necrosis | 2 1 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Fibrosis | 4 | Inflammation, Chronic | 1 1 | Inflammation, Chronic Active | 4 1 | Acinus, Atrophy | 2 | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 4| 7| 5| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 3| 2| 5| 3| 3| 3| 8| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 5| 2| 3| 3| 3| 5| | 1| 3| 1| 2| 0| 1| 0| 1| 6| 1| 0| 1| 1| 1| 1| 1| 3| 1| 1| 0| 8| 1| 1| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Parotid Gland, Inflammation, Chronic | 1 1 | Sublingual Gland, Inflammation, | | Chronic | 1 1 1 1 1 | Submandibular Gland, Inflammation, | | Chronic | 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 2 1 1 1 1 1| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 | Hyperkeratosis | 2 | Inflammation, Chronic Active | 1 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Inflammation, Chronic | 1 | Inflammation, Chronic Active | 1 | Necrosis | 1 | Epithelium, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 1 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia | 1 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + M M M M + M M + + + + M + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 1 | Pars Distalis, Hyperplasia | 1 1 1 2 1| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | C-Cell, Hyperplasia | | Follicular Cell, Hyperplasia | 1 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 4| 7| 5| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 3| 2| 5| 3| 3| 3| 8| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 5| 2| 3| 3| 3| 5| | 1| 3| 1| 2| 0| 1| 0| 1| 6| 1| 0| 1| 1| 1| 1| 1| 3| 1| 1| 0| 8| 1| 1| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Pigmentation | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Cyst | 2 2 3 3 1 2 1 2 2 | Cyst, Multiple | | Hemorrhage | 3 1 2 2 | Periovarian Tissue, Necrosis | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hydrometra | 2 3 | Thrombosis | | Cervix, Inflammation, Acute | | Endometrium, Hyperplasia | 2 3 2 3 2 2 2 1 2 2 2 1 3 2 2 3 4 2 3 3 3 2 3 4| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Sternal, Myelofibrosis | 1 2 3 1 3 1 1 1 2 1 1 2 2 1 1 2 | __________________________________________________________________________| Lymph Node | + + + + + M + + + + + + + M + + + + + + + + + + +| Mandibular, Hyperplasia, Lymphoid | 2 | Mandibular, Inflammation, Chronic | | Active | 1 | Mediastinal, Fibrosis | 1 | Mediastinal, Hyperplasia, Lymphoid | 2 3 | Mediastinal, Inflammation, Chronic | | Active | 1 | Pancreatic, Fibrosis | 2 | Pancreatic, Inflammation, Chronic | | Active | 2 | Renal, Angiectasis | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +| Angiectasis | | Autolysis | 2 | Depletion Lymphoid | 3 | Fibrosis | 2 | Hyperplasia, Lymphoid | 3 | Infiltration Cellular, Histiocyte | 1 1 1| Inflammation, Chronic Active | 2 | Pigmentation | 1 1 1| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | | Fibrosis | 2 | Hematopoietic Cell Proliferation | 3 2 3 2 | Hyperplasia, Lymphoid | 1 | __________________________________________________________________________| Thymus | + + + M + + + + M + + + M + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 4| 7| 5| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 3| 2| 5| 3| 3| 3| 8| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 5| 2| 3| 3| 3| 5| | 1| 3| 1| 2| 0| 1| 0| 1| 6| 1| 0| 1| 1| 1| 1| 1| 3| 1| 1| 0| 8| 1| 1| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Autolysis | | Depletion Lymphoid | | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + M + + M + + + M + + + + + + + M| Hyperplasia | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 1 1 | Glands, Inflammation, Acute | 1 1 1 1| Nasolacrimal Duct, Inflammation, | | Acute | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Renal Tubule, Regeneration | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Autolysis | 3 3 | Inflammation, Chronic | 1 1 1 | Polyarteritis | 2 | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 7| 5| 7| DAY ON TEST | 3| 5| 3| 3| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| 5| 3| 3| 1| 3| | 1| 3| 2| 1| 3| 1| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 0| 0| 2| 2| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | M + M + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Inflammation, Chronic | 1 | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + M + + + +| Autolysis | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia, Lymphoid | 2 | Peyer's Patch, Hyperplasia | 3 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia, Lymphoid | 2 4 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Autolysis | | Clear Cell Focus | | Eosinophilic Focus | 1 | Fatty Change | | Fibrosis | | Hematopoietic Cell Proliferation | 2 | Inflammation, Acute | 1 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 2 1| Mixed Cell Focus | 2 | Necrosis, Coagulative | 1 1 | Necrosis | 1 | Oval Cell, Hyperplasia | 2 | __________________________________________________________________________| Mesentery | + + + + | Fibrosis | 2 1 1 | Necrosis | 3 1 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Fibrosis | | Inflammation, Chronic | 1 1 1 | Inflammation, Chronic Active | | Acinus, Atrophy | 2 | _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 7| 5| 7| DAY ON TEST | 3| 5| 3| 3| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| 5| 3| 3| 1| 3| | 1| 3| 2| 1| 3| 1| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 0| 0| 2| 2| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Parotid Gland, Inflammation, Chronic | | Sublingual Gland, Inflammation, | | Chronic | 1 | Submandibular Gland, Inflammation, | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Hyperkeratosis | | Inflammation, Chronic Active | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Inflammation, Chronic | | Inflammation, Chronic Active | | Necrosis | | Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | M M M + + M + + M + + + + + + M + + M + M + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + M + + + + I + + + + + + + +| Pars Distalis, Angiectasis | 2 1 | Pars Distalis, Hyperplasia | 2 1 1 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | C-Cell, Hyperplasia | | Follicular Cell, Hyperplasia | 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + | _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 7| 5| 7| DAY ON TEST | 3| 5| 3| 3| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| 5| 3| 3| 1| 3| | 1| 3| 2| 1| 3| 1| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 0| 0| 2| 2| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Pigmentation | 1 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 4 | Cyst | 2 2 3 1 1 3 2 1 1 1| Cyst, Multiple | 2 | Hemorrhage | 1 1 2 1 1 | Periovarian Tissue, Necrosis | 4 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1 3 | Hydrometra | 4 2 2 2 4 2 | Thrombosis | 4 | Cervix, Inflammation, Acute | | Endometrium, Hyperplasia | 3 2 2 3 2 3 2 2 2 2 2 1 2 2 2 2 1 2 4 4 2 3 1 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Sternal, Myelofibrosis | 2 2 1 2 1 1 2 1 2 1 1 1 2 1| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Hyperplasia, Lymphoid | | Mandibular, Inflammation, Chronic | | Active | | Mediastinal, Fibrosis | | Mediastinal, Hyperplasia, Lymphoid | | Mediastinal, Inflammation, Chronic | | Active | | Pancreatic, Fibrosis | | Pancreatic, Inflammation, Chronic | | Active | | Renal, Angiectasis | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Autolysis | | Depletion Lymphoid | | Fibrosis | | Hyperplasia, Lymphoid | 3 | Infiltration Cellular, Histiocyte | 1 1 1 | Inflammation, Chronic Active | | Pigmentation | 1 1 1 | __________________________________________________________________________| Spleen | + + + + + M + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | | Fibrosis | | Hematopoietic Cell Proliferation | 1 1 2 | Hyperplasia, Lymphoid | 1 | __________________________________________________________________________| Thymus | + + + + I I + + + + + + + + + + + M + I + + + + +| _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 7| 5| 7| DAY ON TEST | 3| 5| 3| 3| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| 5| 3| 3| 1| 3| | 1| 3| 2| 1| 3| 1| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 0| 0| 2| 2| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Autolysis | | Depletion Lymphoid | | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 1 1 1 1 1 1| Glands, Inflammation, Acute | 1 | Nasolacrimal Duct, Inflammation, | | Acute | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Inflammation, Chronic | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Renal Tubule, Regeneration | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Autolysis | | Inflammation, Chronic | 1 1 1 | Polyarteritis | | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 4| 6| 7| 0| 5| 4| 7| | | DAY ON TEST | 3| 3| 3| 5| 7| 3| 8| 3| 5| 3| | | | 1| 1| 2| 0| 3| 1| 4| 6| 3| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A | 0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + M + + | 58 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 55 | Autolysis | 4 | 2 3.5| Inflammation, Chronic | | 1 1.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 59 | Autolysis | 3 2 | 4 3.3| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | Autolysis | 4 | 3 3.7| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | Autolysis | 4 | 3 2.3| __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | Autolysis | 3 | 3 3.7| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 60 | Autolysis | 3 | 3 3.7| Hyperplasia, Lymphoid | | 1 2.0| Peyer's Patch, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | Autolysis | 3 4 | 4 3.8| Hyperplasia, Lymphoid | | 2 3.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Angiectasis | | 1 2.0| Autolysis | 2 | 1 2.0| Clear Cell Focus | 1 | 5 1.6| Eosinophilic Focus | | 2 1.0| Fatty Change | 1 | 1 1.0| Fibrosis | | 1 2.0| Hematopoietic Cell Proliferation | | 1 2.0| Inflammation, Acute | | 1 1.0| Inflammation, Chronic Active | 1 1 1 1 | 26 1.1| Mixed Cell Focus | 1 | 3 1.3| Necrosis, Coagulative | | 2 1.0| Necrosis | 1 | 2 1.0| Oval Cell, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Mesentery | | 7 | Fibrosis | | 6 1.5| Necrosis | | 5 1.8| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 4| 6| 7| 0| 5| 4| 7| | | DAY ON TEST | 3| 3| 3| 5| 7| 3| 8| 3| 5| 3| | | | 1| 1| 2| 0| 3| 1| 4| 6| 3| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A | 0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Autolysis | 2 | 1 2.0| Fibrosis | | 1 4.0| Inflammation, Chronic | | 5 1.0| Inflammation, Chronic Active | | 2 2.5| Acinus, Atrophy | | 2 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | Parotid Gland, Inflammation, Chronic | 2 | 3 1.3| Sublingual Gland, Inflammation, | | | Chronic | 1 | 7 1.0| Submandibular Gland, Inflammation, | | | Chronic | 1 1 1 1 1 1 1 1 | 51 1.1| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + M + + + | 59 | Acanthosis | | 1 2.0| Hyperkeratosis | | 1 2.0| Inflammation, Chronic Active | | 2 1.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Autolysis | 3 | 1 3.0| Inflammation, Chronic | | 1 1.0| Inflammation, Chronic Active | 1 | 2 1.0| Necrosis | | 1 1.0| Epithelium, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Inflammation, Chronic Active | | 7 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 60 | Hematopoietic Cell Proliferation | | 1 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | Autolysis | 2 | 1 2.0| Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + M M M + M + | 39 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + M M + + | 56 | Pars Distalis, Angiectasis | | 3 1.3| Pars Distalis, Hyperplasia | 2 | 10 1.4| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 4| 6| 7| 0| 5| 4| 7| | | DAY ON TEST | 3| 3| 3| 5| 7| 3| 8| 3| 5| 3| | | | 1| 1| 2| 0| 3| 1| 4| 6| 3| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A | 0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | Inflammation, Chronic Active | 1 1 | 4 1.0| C-Cell, Hyperplasia | 1 | 1 1.0| Follicular Cell, Hyperplasia | | 5 1.2| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | | 1 | Pigmentation | | 1 1.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 60 | Abscess | | 1 4.0| Cyst | 1 1 2 3 3 1 | 25 1.8| Cyst, Multiple | | 1 2.0| Hemorrhage | 1 1 1 | 12 1.4| Periovarian Tissue, Necrosis | | 1 4.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 60 | Angiectasis | | 3 2.0| Hydrometra | 3 3 3 4 | 12 2.8| Thrombosis | | 1 4.0| Cervix, Inflammation, Acute | 2 | 1 2.0| Endometrium, Hyperplasia | 2 2 2 1 3 2 2 | 55 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Sternal, Myelofibrosis | 1 2 1 2 2 3 | 36 1.6| __________________________________________________________________________|____________| Lymph Node | + + + + + + M + + + | 57 | Mandibular, Hyperplasia, Lymphoid | | 1 2.0| Mandibular, Inflammation, Chronic | | | Active | 1 | 2 1.0| Mediastinal, Fibrosis | | 1 1.0| Mediastinal, Hyperplasia, Lymphoid | | 2 2.5| Mediastinal, Inflammation, Chronic | | | Active | | 1 1.0| Pancreatic, Fibrosis | | 1 2.0| Pancreatic, Inflammation, Chronic | | | Active | | 1 2.0| Renal, Angiectasis | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 4| 6| 7| 0| 5| 4| 7| | | DAY ON TEST | 3| 3| 3| 5| 7| 3| 8| 3| 5| 3| | | | 1| 1| 2| 0| 3| 1| 4| 6| 3| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A | 0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + M + + + | 58 | Angiectasis | 2 | 1 2.0| Autolysis | | 1 2.0| Depletion Lymphoid | | 1 3.0| Fibrosis | | 1 2.0| Hyperplasia, Lymphoid | | 2 3.0| Infiltration Cellular, Histiocyte | 1 1 | 8 1.0| Inflammation, Chronic Active | | 1 2.0| Pigmentation | 1 1 | 8 1.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 59 | Depletion Lymphoid | 4 | 1 4.0| Fibrosis | | 1 2.0| Hematopoietic Cell Proliferation | | 7 2.0| Hyperplasia, Lymphoid | 1 | 3 1.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 53 | Autolysis | 2 | 1 2.0| Depletion Lymphoid | 4 | 1 4.0| Inflammation, Chronic Active | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + + + + + + | 54 | Hyperplasia | 1 | 2 1.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Autolysis | 1 | 1 1.0| Thalamus, Mineralization | 1 1 1 1 1 1 1 1 | 50 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Infiltration Cellular, Histiocyte | | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | Inflammation, Acute | 1 | 9 1.0| Glands, Inflammation, Acute | | 5 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 4| 6| 7| 0| 5| 4| 7| | | DAY ON TEST | 3| 3| 3| 5| 7| 3| 8| 3| 5| 3| | | | 1| 1| 2| 0| 3| 1| 4| 6| 3| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A | 0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Nasolacrimal Duct, Inflammation, | | | Acute | 1 | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Autolysis | | 1 3.0| Inflammation, Chronic | 1 1 1 1 1 1 1 | 56 1.0| Renal Tubule, Regeneration | 1 | 2 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | Angiectasis | | 1 2.0| Autolysis | 4 | 3 3.3| Inflammation, Chronic | 1 | 7 1.0| Polyarteritis | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 4| 2| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| DAY ON TEST | 3| 5| 8| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 0| | 7| 3| 1| 7| 7| 7| 7| 7| 7| 7| 3| 9| 6| 6| 7| 3| 7| 7| 6| 0| 6| 6| 3| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Inflammation, Chronic | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia, Lymphoid | | Inflammation, Chronic Active | 1 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Inflammation, Chronic Active | 1 | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia, Lymphoid | 2 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | 2 | Eosinophilic Focus | 1 1 | Fatty Change | 1 | Hematopoietic Cell Proliferation | 1 | Inflammation, Chronic | 1 1 | Inflammation, Chronic Active | 2 1 1 1 1 1 1 1 1 1 1 1 1 | Mixed Cell Focus | | Necrosis | 1 1 1 1 1 1 | __________________________________________________________________________| Mesentery | + + + | Fibrosis | 2 1 1 | Inflammation, Chronic | 2 1 1 | Necrosis, Coagulative | | Necrosis | 1 1 1 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + +| Cyst | | Cytoplasmic Alteration | 1 1 | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + +| Submandibular Gland, Atrophy | 2 2 | Submandibular Gland, Inflammation, | | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 4| 2| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| DAY ON TEST | 3| 5| 8| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 0| | 7| 3| 1| 7| 7| 7| 7| 7| 7| 7| 3| 9| 6| 6| 7| 3| 7| 7| 6| 0| 6| 6| 3| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Chronic | 2 1 1 1 1 2 1 1 1 1 1 1 1 1| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Inflammation, Chronic | | Inflammation, Chronic Active | | Mineralization | 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 | Mineralization | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | Hyperplasia | 1 | Pigmentation | 1 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + M + + M M + M M + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + + + + + I + + +| Inflammation, Chronic | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + M + +| Pars Distalis, Angiectasis | | Pars Distalis, Cyst | 1 | Pars Distalis, Hyperplasia | 2 1 2 1 1| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Chronic Active | 1 | C-Cell, Hyperplasia | | Follicular Cell, Hyperplasia | 1 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + M + + | Cyst | 1 | Cyst, Multiple | 3 | Inflammation, Acute | 1 | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 4| 2| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| DAY ON TEST | 3| 5| 8| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 0| | 7| 3| 1| 7| 7| 7| 7| 7| 7| 7| 3| 9| 6| 6| 7| 3| 7| 7| 6| 0| 6| 6| 3| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Inflammation, Chronic | | Inflammation, Chronic Active | | Pigmentation | 1 | Duct, Dilatation | 1 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + M + + + + + + +| Cyst | 3 3 2 2 2 1 1 1 3| Hemorrhage | | Periovarian Tissue, Cyst | | Periovarian Tissue, Inflammation, | | Chronic | 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | 3 2 | Infarct | | Metaplasia, Osseous | 1 | Endometrium, Hyperplasia | 3 3 2 2 2 2 2 3 2 2 2 2 3 3 2 3 2 2 3| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + +| Myeloid Cell, Sternal, Hyperplasia | 2 | Sternal, Myelofibrosis | 1 1 2 1 1 2 2 2 3 1 1 2 1 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + M| Mandibular, Hyperplasia, Lymphoid | 3 | Mandibular, Pigmentation | 1 | __________________________________________________________________________| Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + M| Hematopoietic Cell Proliferation | 1 | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 2 | Hematopoietic Cell Proliferation | 4 | Hyperplasia, Lymphoid | 2 1 2 | __________________________________________________________________________| Thymus | + M + + + + + + + M + + + M + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + M + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Inflammation, | | Acute | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 4| 2| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| DAY ON TEST | 3| 5| 8| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 0| | 7| 3| 1| 7| 7| 7| 7| 7| 7| 7| 3| 9| 6| 6| 7| 3| 7| 7| 6| 0| 6| 6| 3| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 1 1 1 1 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cornea, Inflammation, Chronic Active | 1 | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + +| Glomerulosclerosis | | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1| Metaplasia, Osseous | 1 | Renal Tubule, Degeneration, Hyaline | 2 | Renal Tubule, Regeneration | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Inflammation, Chronic Active | 1 | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 2| 6| 7| 6| 7| 7| 4| DAY ON TEST | 3| 1| 5| 3| 3| 5| 3| 3| 3| 3| 5| 3| 5| 3| 3| 3| 3| 6| 0| 8| 3| 6| 3| 3| 5| | 6| 8| 0| 7| 6| 0| 6| 6| 6| 6| 2| 6| 0| 6| 6| 6| 7| 7| 6| 1| 6| 6| 6| 7| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Gallbladder | + + + + + M + + I + + + + + + + + + + + + | Autolysis | 4 | Inflammation, Chronic | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | Hyperplasia, Lymphoid | | Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + | Clear Cell Focus | 1 | Eosinophilic Focus | | Fatty Change | 1 | Hematopoietic Cell Proliferation | | Inflammation, Chronic | | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 | Mixed Cell Focus | | Necrosis | 1 1 1 1 1 1 | __________________________________________________________________________| Mesentery | + + + | Fibrosis | 1 1 1 | Inflammation, Chronic | 1 1 | Necrosis, Coagulative | 3 | Necrosis | 1 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + | Cyst | 4 | Cytoplasmic Alteration | 1 | Inflammation, Chronic Active | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + | Submandibular Gland, Atrophy | | Submandibular Gland, Inflammation, | | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 2| 6| 7| 6| 7| 7| 4| DAY ON TEST | 3| 1| 5| 3| 3| 5| 3| 3| 3| 3| 5| 3| 5| 3| 3| 3| 3| 6| 0| 8| 3| 6| 3| 3| 5| | 6| 8| 0| 7| 6| 0| 6| 6| 6| 6| 2| 6| 0| 6| 6| 6| 7| 7| 6| 1| 6| 6| 6| 7| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Chronic | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 2 | Inflammation, Chronic | 1 | Inflammation, Chronic Active | 1 1 | Mineralization | 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | 1 | Mineralization | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + | Hematopoietic Cell Proliferation | 2 | Hyperplasia | | Pigmentation | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + I + + + + + + + + + + + + + + + | Hyperplasia | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Parathyroid Gland | + + + M + + + + + M M + M + + + + + + + + | Inflammation, Chronic | 1 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + | Pars Distalis, Angiectasis | 1 2 2 | Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 1 2 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + | Cyst | 2 1 | Inflammation, Chronic Active | 1 1 | C-Cell, Hyperplasia | | Follicular Cell, Hyperplasia | 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + +| Cyst | | Cyst, Multiple | 2 2| Inflammation, Acute | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 2| 6| 7| 6| 7| 7| 4| DAY ON TEST | 3| 1| 5| 3| 3| 5| 3| 3| 3| 3| 5| 3| 5| 3| 3| 3| 3| 6| 0| 8| 3| 6| 3| 3| 5| | 6| 8| 0| 7| 6| 0| 6| 6| 6| 6| 2| 6| 0| 6| 6| 6| 7| 7| 6| 1| 6| 6| 6| 7| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Inflammation, Chronic | | Inflammation, Chronic Active | 1 1| Pigmentation | 1 | Duct, Dilatation | | __________________________________________________________________________| Ovary | + + + + + + M + + + + + + + + + + + + + + +| Cyst | 2 3 4 2 3 3 4 2 | Hemorrhage | 2 2 | Periovarian Tissue, Cyst | 4| Periovarian Tissue, Inflammation, | | Chronic | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | 2 4 3 3 3 3 3 2 4| Infarct | 3 | Metaplasia, Osseous | | Endometrium, Hyperplasia | 2 2 2 3 2 3 2 1 2 2 1 3 2 1 1 2 2 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + | Myeloid Cell, Sternal, Hyperplasia | | Sternal, Myelofibrosis | 2 2 2 2 2 2 2 1 2 2 2 2 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + M + + I + + | Mandibular, Hyperplasia, Lymphoid | | Mandibular, Pigmentation | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + I + + | Hematopoietic Cell Proliferation | | Hyperplasia, Lymphoid | 2 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + | Depletion Lymphoid | 1 | Hematopoietic Cell Proliferation | 4 4 | Hyperplasia, Lymphoid | | __________________________________________________________________________| Thymus | + + + + + + + + + + + M + + M M + + M + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Inflammation, | | Acute | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 2| 6| 7| 6| 7| 7| 4| DAY ON TEST | 3| 1| 5| 3| 3| 5| 3| 3| 3| 3| 5| 3| 5| 3| 3| 3| 3| 6| 0| 8| 3| 6| 3| 3| 5| | 6| 8| 0| 7| 6| 0| 6| 6| 6| 6| 2| 6| 0| 6| 6| 6| 7| 7| 6| 1| 6| 6| 6| 7| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Acute | 1 1 1 1 1 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cornea, Inflammation, Chronic Active | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + | Glomerulosclerosis | 4 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 | Metaplasia, Osseous | 1 | Renal Tubule, Degeneration, Hyaline | 2 1 | Renal Tubule, Regeneration | 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + | Autolysis | 3 | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 3| 5| | | | 7| 7| 7| 7| 7| 7| 7| 3| 7| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | A | 2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L | PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + M + + + + + | 48 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + | 48 | Autolysis | | 1 4.0| Inflammation, Chronic | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | Autolysis | | 1 3.0| Hyperplasia, Lymphoid | 1 | 1 1.0| Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | Autolysis | | 1 3.0| Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | Autolysis | | 1 3.0| Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | Autolysis | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 60 | Autolysis | | 1 3.0| Hyperplasia, Lymphoid | | 3 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | Autolysis | | 1 3.0| __________________________________________________________________________|____________| Liver | + + + + + + + + | 52 | Clear Cell Focus | | 2 1.5| Eosinophilic Focus | | 2 1.0| Fatty Change | | 2 1.0| Hematopoietic Cell Proliferation | | 1 1.0| Inflammation, Chronic | | 2 1.0| Inflammation, Chronic Active | 1 1 1 | 29 1.0| Mixed Cell Focus | 3 | 1 3.0| Necrosis | | 12 1.0| __________________________________________________________________________|____________| Mesentery | + + | 8 | Fibrosis | 1 2 | 8 1.3| Inflammation, Chronic | | 5 1.2| Necrosis, Coagulative | | 1 3.0| Necrosis | 1 2 | 6 1.2| __________________________________________________________________________|____________| Pancreas | + + + + + + + + | 50 | Cyst | 2 | 2 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 3| 5| | | | 7| 7| 7| 7| 7| 7| 7| 3| 7| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | A | 2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L | PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Cytoplasmic Alteration | | 3 1.0| Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + | 50 | Submandibular Gland, Atrophy | | 2 2.0| Submandibular Gland, Inflammation, | | | Chronic | 1 1 1 2 1 1 | 34 1.1| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Hyperkeratosis | | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Autolysis | | 1 2.0| Inflammation, Chronic | | 1 1.0| Inflammation, Chronic Active | | 2 1.0| Mineralization | | 3 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + | 50 | Inflammation, Chronic Active | 1 | 4 1.0| Mineralization | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + | 51 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + | 51 | Hematopoietic Cell Proliferation | | 1 2.0| Hyperplasia | | 1 1.0| Pigmentation | | 1 1.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + | 45 | Hyperplasia | 2 1 | 3 1.3| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 50 | __________________________________________________________________________|____________| Parathyroid Gland | M M + M + + M M | 39 | Inflammation, Chronic | | 1 1.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + | 49 | Pars Distalis, Angiectasis | 2 | 4 1.8| Pars Distalis, Cyst | | 1 1.0| Pars Distalis, Hyperplasia | 2 2 | 11 1.6| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 50 | Cyst | | 2 1.5| Inflammation, Chronic Active | | 3 1.0| C-Cell, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 3| 5| | | | 7| 7| 7| 7| 7| 7| 7| 3| 7| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | A | 2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L | PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Follicular Cell, Hyperplasia | 1 | 8 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 2 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M + | 7 | Cyst | | 1 1.0| Cyst, Multiple | 2 | 4 2.3| Inflammation, Acute | | 1 1.0| Inflammation, Chronic | 1 | 1 1.0| Inflammation, Chronic Active | | 2 1.0| Pigmentation | 1 | 3 1.0| Duct, Dilatation | | 1 1.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + | 51 | Cyst | 2 4 1 | 20 2.4| Hemorrhage | | 2 2.0| Periovarian Tissue, Cyst | | 1 4.0| Periovarian Tissue, Inflammation, | | | Chronic | | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + | 54 | Hydrometra | 4 4 | 13 3.1| Infarct | | 1 3.0| Metaplasia, Osseous | | 1 1.0| Endometrium, Hyperplasia | 2 3 2 2 2 2 3 2 | 46 2.2| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | | 1 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + | 50 | Myeloid Cell, Sternal, Hyperplasia | | 1 2.0| Sternal, Myelofibrosis | 1 1 4 2 2 1 2 | 32 1.8| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + | 47 | Mandibular, Hyperplasia, Lymphoid | | 1 3.0| Mandibular, Pigmentation | | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + | 46 | Hematopoietic Cell Proliferation | | 1 1.0| Hyperplasia, Lymphoid | | 3 1.7| __________________________________________________________________________|____________| Spleen | + + + + + + + + + | 51 | Depletion Lymphoid | | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 3| 5| | | | 7| 7| 7| 7| 7| 7| 7| 3| 7| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | A | 2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L | PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hematopoietic Cell Proliferation | | 3 4.0| Hyperplasia, Lymphoid | 2 | 4 1.8| __________________________________________________________________________|____________| Thymus | + + + + + + + + | 43 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + M M + | 48 | __________________________________________________________________________|____________| Skin | + + + + + + + + | 52 | Subcutaneous Tissue, Inflammation, | | | Acute | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + | 50 | Thalamus, Mineralization | 1 1 1 1 1 1 | 25 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + | 50 | Inflammation, Chronic Active | 1 | 2 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + | 50 | Inflammation, Acute | 1 1 | 15 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Cornea, Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Harderian Gland | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + | 50 | Glomerulosclerosis | | 1 4.0| Inflammation, Chronic | 1 1 1 1 1 1 | 40 1.1| Metaplasia, Osseous | | 2 1.0| Renal Tubule, Degeneration, Hyaline | | 3 1.7| Renal Tubule, Regeneration | 1 | 3 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + | 50 | Autolysis | | 1 3.0| Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 6| 0| 7| 7| 7| 4| 7| 4| 0| 7| 7| 7| 6| 4| 7| 0| 7| 7| 4| 6| 7| 4| 5| 7| DAY ON TEST | 3| 6| 0| 3| 3| 3| 3| 3| 0| 1| 3| 3| 3| 0| 5| 3| 0| 0| 3| 5| 7| 3| 5| 2| 3| | 3| 7| 6| 6| 6| 3| 7| 3| 0| 3| 3| 3| 3| 9| 3| 3| 9| 5| 3| 3| 7| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + A + + + + + + A M + + + + + + + M + + +| Autolysis | 2 | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | __________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + A + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + A + + + + + + + +| Autolysis | 4 | Inflammation, Chronic | | __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 | Hyperplasia, Lymphoid | | Epithelium, Hyperplasia | | __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + A + + + + + + + +| Autolysis | 4 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | | Clear Cell Focus | X | Eosinophilic Focus | 2 | Fatty Change | | Infarct | 4 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 | Mixed Cell Focus | 1 | Necrosis, Coagulative | | Necrosis | 1 | __________________________________________________________________________| Mesentery | + | Fibrosis | 2 | Hemorrhage | | Inflammation, Chronic | | Inflammation, Chronic Active | 2 | Necrosis, Coagulative | | Necrosis | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Cytoplasmic Alteration | 1 | Fibrosis | | Inflammation, Chronic Active | | Acinus, Atrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| Sublingual Gland, Inflammation, | | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 6| 0| 7| 7| 7| 4| 7| 4| 0| 7| 7| 7| 6| 4| 7| 0| 7| 7| 4| 6| 7| 4| 5| 7| DAY ON TEST | 3| 6| 0| 3| 3| 3| 3| 3| 0| 1| 3| 3| 3| 0| 5| 3| 0| 0| 3| 5| 7| 3| 5| 2| 3| | 3| 7| 6| 6| 6| 3| 7| 3| 0| 3| 3| 3| 3| 9| 3| 3| 9| 5| 3| 3| 7| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Chronic | 1 | Submandibular Gland, Inflammation, | | Chronic | 1 2 1 1 1 1 1 2 1 1 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 1| Hyperkeratosis | 1 1| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + M + + + + + + + + + + + + + + + +| Inflammation, Chronic | | Inflammation | 1 | Necrosis | | Epithelium, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 | Fibrosis | 1 | Inflammation, Chronic Active | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + M M + M + + M + M| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + M + + M + + + + M + M + M + +| __________________________________________________________________________| Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 2 1 2 | __________________________________________________________________________| Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + +| Cyst Multilocular | | Inflammation, Chronic Active | 2 | Polyarteritis | 2 | Ultimobranchial Cyst | X | Follicular Cell, Hyperplasia | 3 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + | Cyst | | Inflammation, Chronic | | Pigmentation | 1 1 1 1 | Duct, Dilatation | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 6| 0| 7| 7| 7| 4| 7| 4| 0| 7| 7| 7| 6| 4| 7| 0| 7| 7| 4| 6| 7| 4| 5| 7| DAY ON TEST | 3| 6| 0| 3| 3| 3| 3| 3| 0| 1| 3| 3| 3| 0| 5| 3| 0| 0| 3| 5| 7| 3| 5| 2| 3| | 3| 7| 6| 6| 6| 3| 7| 3| 0| 3| 3| 3| 3| 9| 3| 3| 9| 5| 3| 3| 7| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Angiectasis | | Cyst | 1 2 2 2 2 1 2 4 1 | Hemorrhage | 2 2 | __________________________________________________________________________| Uterus | + + M + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Hydrometra | 3 2 3 4 4| Endometrium, Hyperplasia | 2 2 2 3 2 2 2 3 2 3 1 2 3 3 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + A + + + + + + + + + + + + + + + + + + +| Sternal, Myelofibrosis | 2 2 2 1 1 1 1 1 2 1 3 2 3| __________________________________________________________________________| Lymph Node | + + + + + + + M + + + + + + + + M + + + + +| Pancreatic, Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + M + A + + + + + + M + + + + +| Angiectasis | | Depletion Lymphoid | 4 | Hyperplasia, Lymphoid | | Thrombosis | 2 | __________________________________________________________________________| Spleen | + + M + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 2 | Fibrosis | | Hematopoietic Cell Proliferation | 2 | Hyperplasia, Lymphoid | | Inflammation, Granulomatous | | __________________________________________________________________________| Thymus | + + M + + + + + + + + + + + + + + + + + M +| Depletion Lymphoid | 3 | Hyperplasia, Lymphoid | 2 | Necrosis | 4 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M + + + + + + + + + + M + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | Epidermis, Inflammation, Acute | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| Joint, Tarsal, Hyperostosis | 2 | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 6| 0| 7| 7| 7| 4| 7| 4| 0| 7| 7| 7| 6| 4| 7| 0| 7| 7| 4| 6| 7| 4| 5| 7| DAY ON TEST | 3| 6| 0| 3| 3| 3| 3| 3| 0| 1| 3| 3| 3| 0| 5| 3| 0| 0| 3| 5| 7| 3| 5| 2| 3| | 3| 7| 6| 6| 6| 3| 7| 3| 0| 3| 3| 3| 3| 9| 3| 3| 9| 5| 3| 3| 7| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Thalamus, Mineralization | 1 1 1 1 1 1| __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 1 1 2 | Inflammation, Chronic Active | | Metaplasia, Osseous | 1 | __________________________________________________________________________| Nose | + + M + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 1 1 1 1 1 1 1 | Vomeronasal Organ, Inflammation, | | Acute | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Lens, Cataract | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 | Papilla, Necrosis | | Renal Tubule, Atrophy | | Renal Tubule, Regeneration | 1 2 1 | Transitional Epithelium, Hyperplasia | | __________________________________________________________________________| Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + +| Autolysis | 2 | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 5| 7| 4| 4| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 5| 5| 3| 5| 6| 3| 3| 0| 2| 3| 5| 3| 6| 1| 5| 3| 3| 3| 3| 3| 3| 3| | 3| 4| 3| 0| 0| 3| 0| 7| 3| 3| 3| 1| 3| 0| 3| 2| 4| 0| 3| 3| 3| 3| 3| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + M + + + + + + + + +| Autolysis | 4 3 | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +| Autolysis | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +| Autolysis | 2 | Inflammation, Chronic | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +| Autolysis | 2 | Hyperplasia, Lymphoid | | Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +| Autolysis | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | 1 | Clear Cell Focus | 1 | Eosinophilic Focus | 1 1 1 1 1 1 | Fatty Change | 1 1 | Infarct | | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1| Mixed Cell Focus | | Necrosis, Coagulative | 1 1 | Necrosis | | __________________________________________________________________________| Mesentery | + + + + | Fibrosis | 2 2 1 1 | Hemorrhage | 2 | Inflammation, Chronic | 2 1 | Inflammation, Chronic Active | 2 | Necrosis, Coagulative | 2 2 | Necrosis | 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + M M + + + + + + + + + + +| Cyst | 4 | Cytoplasmic Alteration | | Fibrosis | | Inflammation, Chronic Active | | Acinus, Atrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + +| Sublingual Gland, Inflammation, | | _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 5| 7| 4| 4| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 5| 5| 3| 5| 6| 3| 3| 0| 2| 3| 5| 3| 6| 1| 5| 3| 3| 3| 3| 3| 3| 3| | 3| 4| 3| 0| 0| 3| 0| 7| 3| 3| 3| 1| 3| 0| 3| 2| 4| 0| 3| 3| 3| 3| 3| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Chronic | | Submandibular Gland, Inflammation, | | Chronic | 1 2 1 1 1 1 1 1 2 1 1 1 1 1| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Hyperkeratosis | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 | Inflammation | | Necrosis | 1 | Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | | Fibrosis | | Inflammation, Chronic Active | 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + M M M + M M + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + M M + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + M + + + M + M + M + + + M M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 2 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + +| Cyst Multilocular | 2 | Inflammation, Chronic Active | | Polyarteritis | | Ultimobranchial Cyst | | Follicular Cell, Hyperplasia | 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + | Cyst | | Inflammation, Chronic | | Pigmentation | 1 1 | Duct, Dilatation | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 5| 7| 4| 4| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 5| 5| 3| 5| 6| 3| 3| 0| 2| 3| 5| 3| 6| 1| 5| 3| 3| 3| 3| 3| 3| 3| | 3| 4| 3| 0| 0| 3| 0| 7| 3| 3| 3| 1| 3| 0| 3| 2| 4| 0| 3| 3| 3| 3| 3| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Angiectasis | 2 | Cyst | 2 3 1 1 2 2| Hemorrhage | 3 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Hydrometra | 3 3 2 2 2 3 2 4 | Endometrium, Hyperplasia | 2 2 2 1 3 2 2 2 3 2 2 1 1 2 2 2 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + +| Sternal, Myelofibrosis | 1 1 1 2 1 2 2 1 3 2 1 2 3 1 1 1| __________________________________________________________________________| Lymph Node | + + + + + + + + M + + + + + + + + + + +| Pancreatic, Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + +| Angiectasis | 2 | Depletion Lymphoid | | Hyperplasia, Lymphoid | 2 | Thrombosis | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | | Fibrosis | | Hematopoietic Cell Proliferation | 2 | Hyperplasia, Lymphoid | | Inflammation, Granulomatous | | __________________________________________________________________________| Thymus | + + + + + + + I M + + + + + + I + + + +| Depletion Lymphoid | | Hyperplasia, Lymphoid | | Necrosis | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | Epidermis, Inflammation, Acute | 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + +| Joint, Tarsal, Hyperostosis | | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 5| 7| 4| 4| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 5| 5| 3| 5| 6| 3| 3| 0| 2| 3| 5| 3| 6| 1| 5| 3| 3| 3| 3| 3| 3| 3| | 3| 4| 3| 0| 0| 3| 0| 7| 3| 3| 3| 1| 3| 0| 3| 2| 4| 0| 3| 3| 3| 3| 3| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | | Inflammation, Chronic Active | | Metaplasia, Osseous | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 1 1 1 1 | Vomeronasal Organ, Inflammation, | | Acute | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Lens, Cataract | 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Papilla, Necrosis | 3 | Renal Tubule, Atrophy | 1 | Renal Tubule, Regeneration | 3 | Transitional Epithelium, Hyperplasia | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | | DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 5| 3| | | | 6| 4| 6| 3| 3| 6| 6| 6| 0| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A | 10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L | PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + M + + + + + + | 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + | 46 | Autolysis | | 3 3.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 59 | Autolysis | | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 57 | Autolysis | | 2 3.0| Inflammation, Chronic | 1 | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 58 | Autolysis | | 2 3.0| Hyperplasia, Lymphoid | 2 | 1 2.0| Epithelium, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 57 | Autolysis | | 1 4.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 56 | Angiectasis | 2 | 1 2.0| Basophilic Focus | 2 | 2 1.5| Clear Cell Focus | 1 | 3 1.0| Eosinophilic Focus | 2 | 8 1.3| Fatty Change | | 2 1.0| Infarct | | 1 4.0| Inflammation, Chronic Active | 1 2 1 1 2 1 1 1 | 27 1.1| Mixed Cell Focus | 2 | 2 1.5| Necrosis, Coagulative | | 2 1.0| Necrosis | 1 2 | 3 1.3| __________________________________________________________________________|____________| Mesentery | | 5 | Fibrosis | | 5 1.6| Hemorrhage | | 1 2.0| Inflammation, Chronic | | 2 1.5| Inflammation, Chronic Active | | 2 2.0| Necrosis, Coagulative | | 2 2.0| Necrosis | | 3 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + | 49 | Cyst | | 1 4.0| Cytoplasmic Alteration | 1 | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | | DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 5| 3| | | | 6| 4| 6| 3| 3| 6| 6| 6| 0| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A | 10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L | PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Fibrosis | 4 | 1 4.0| Inflammation, Chronic Active | 4 | 1 4.0| Acinus, Atrophy | 4 | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + | 51 | Sublingual Gland, Inflammation, | | | Chronic | 1 | 2 1.0| Submandibular Gland, Inflammation, | | | Chronic | 1 1 1 1 2 1 1 | 31 1.2| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 59 | Acanthosis | | 2 1.0| Hyperkeratosis | | 2 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 59 | Inflammation, Chronic | 1 | 3 1.0| Inflammation | | 1 1.0| Necrosis | | 1 1.0| Epithelium, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + | 51 | Cardiomyopathy | | 1 1.0| Fibrosis | | 1 1.0| Inflammation, Chronic Active | 1 | 3 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + | 51 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + | 51 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + M | 40 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + | 49 | __________________________________________________________________________|____________| Parathyroid Gland | + M M M M + M M M | 32 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + | 50 | Pars Distalis, Hyperplasia | 1 | 7 1.7| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + | 50 | Cyst Multilocular | | 1 2.0| Inflammation, Chronic Active | 1 | 2 1.5| Polyarteritis | | 1 2.0| Ultimobranchial Cyst | | 1 | Follicular Cell, Hyperplasia | 2 1 | 7 1.6| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | | DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 5| 3| | | | 6| 4| 6| 3| 3| 6| 6| 6| 0| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A | 10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L | PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + | 9 | Cyst | 2 | 1 2.0| Inflammation, Chronic | 1 | 1 1.0| Pigmentation | 1 | 7 1.0| Duct, Dilatation | | 2 2.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + | 50 | Angiectasis | | 1 2.0| Cyst | 2 2 4 | 18 2.0| Hemorrhage | | 4 2.3| __________________________________________________________________________|____________| Uterus | + + + + + + + + + | 53 | Angiectasis | | 2 2.0| Hydrometra | 3 | 14 2.9| Endometrium, Hyperplasia | 2 1 2 2 2 2 3 2 | 40 2.1| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | | 1 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + | 50 | Sternal, Myelofibrosis | 1 2 2 1 1 1 2 | 36 1.6| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + | 48 | Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + | 47 | Angiectasis | | 1 2.0| Depletion Lymphoid | | 1 4.0| Hyperplasia, Lymphoid | 2 | 2 2.0| Thrombosis | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + | 50 | Depletion Lymphoid | | 1 2.0| Fibrosis | 2 | 1 2.0| Hematopoietic Cell Proliferation | | 2 2.0| Hyperplasia, Lymphoid | 2 | 1 2.0| Inflammation, Granulomatous | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + M + + + + + + + | 45 | Depletion Lymphoid | | 1 3.0| Hyperplasia, Lymphoid | | 1 2.0| Necrosis | | 1 4.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + | 49 | Hyperplasia | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | | DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 5| 3| | | | 6| 4| 6| 3| 3| 6| 6| 6| 0| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A | 10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L | PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + | 55 | Cyst Epithelial Inclusion | | 1 | Epidermis, Inflammation, Acute | | 1 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + | 51 | Joint, Tarsal, Hyperostosis | | 1 2.0| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + | 51 | Thalamus, Mineralization | 1 1 1 1 1 1 | 29 1.0| __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + | 52 | Infiltration Cellular, Histiocyte | | 3 1.3| Inflammation, Chronic Active | 3 | 1 3.0| Metaplasia, Osseous | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + | 50 | Inflammation, Acute | 1 1 1 1 1 | 16 1.0| Vomeronasal Organ, Inflammation, | | | Acute | | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + | 51 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Lens, Cataract | | 1 1.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + | 51 | Inflammation, Chronic | 1 1 1 1 1 2 1 1 1 | 45 1.1| Papilla, Necrosis | | 1 3.0| Renal Tubule, Atrophy | | 1 1.0| Renal Tubule, Regeneration | | 4 1.8| Transitional Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + | 50 | Autolysis | | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 2| DAY ON TEST | 2| 2| 2| 2| 5| 2| 2| 0| 2| 6| 2| 3| 3| 2| 2| 5| 2| 2| 4| 3| 3| 3| 0| 5| 3| | 9| 9| 9| 9| 3| 9| 9| 3| 9| 2| 9| 0| 0| 9| 9| 3| 9| 9| 9| 0| 2| 0| 1| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + M + + + + + + + + + + + + + + + + +| Autolysis | 3 | Inflammation, Chronic | 1 | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Pigmentation | 1 1 1 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Pigmentation | 1 1 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + + + +| Autolysis | 3 | Hyperplasia, Lymphoid | 2 4 | Epithelium, Pigmentation | 2 1 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 | Epithelium, Pigmentation | 1 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | | Eosinophilic Focus | 2 2 1 1 | Inflammation, Acute | | Inflammation, Chronic | 1 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Mixed Cell Focus | | Necrosis, Coagulative | 1 | __________________________________________________________________________| Mesentery | + + + | Fibrosis | 1 1 | Hemorrhage | 1 | Inflammation, Chronic Active | 1 1 | Necrosis | 1 4 1 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Parotid Gland, Atrophy | 1 | Parotid Gland, Inflammation, Chronic | 2 1 | Sublingual Gland, Inflammation, | | Chronic | 1 1 | Submandibular Gland, Inflammation, | | Chronic | 2 1 1 1 1 2 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 2| DAY ON TEST | 2| 2| 2| 2| 5| 2| 2| 0| 2| 6| 2| 3| 3| 2| 2| 5| 2| 2| 4| 3| 3| 3| 0| 5| 3| | 9| 9| 9| 9| 3| 9| 9| 3| 9| 2| 9| 0| 0| 9| 9| 3| 9| 9| 9| 0| 2| 0| 1| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 2 | Hyperkeratosis | 1 1 | Hyperplasia, Basal Cell | 2 | Inflammation, Chronic Active | 1 | Ulcer, Acute | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Mineralization | 1 1 | Epithelium, Hyperplasia | | Epithelium, Pigmentation | 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | | Inflammation, Chronic Active | 1 | Endothelium, Hyperplasia | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + M M + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | M + + + + + + + + + + + + + + + + + + + + + M + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + M + M + + + + + M M + M M M + M M M + + M M| Inflammation, Chronic | 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Cyst | 1 | Pars Distalis, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 1 2 | Ultimobranchial Cyst | | C-Cell, Hyperplasia | 1 1 | Follicular Cell, Hyperplasia | 1 2 1 2 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Hemorrhage | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | Cyst, Multiple | | Pigmentation | | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 2| DAY ON TEST | 2| 2| 2| 2| 5| 2| 2| 0| 2| 6| 2| 3| 3| 2| 2| 5| 2| 2| 4| 3| 3| 3| 0| 5| 3| | 9| 9| 9| 9| 3| 9| 9| 3| 9| 2| 9| 0| 0| 9| 9| 3| 9| 9| 9| 0| 2| 0| 1| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Duct, Dilatation | | __________________________________________________________________________| Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +| Cyst | 2 2 3 4 2 2 4 1 | Hemorrhage | 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hydrometra | 3 4 3 2 2 1 3 2 3 3 4 3 | Thrombosis | | Endometrium, Hyperplasia | 2 2 3 2 2 2 2 1 2 3 1 1 2 1 2 2 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Sternal, Myelofibrosis | 2 2 2 2 1 4 1 1 1 2 2 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Depletion Lymphoid | 3 | Infiltration Cellular, Histiocyte | 1 1 1 | Pigmentation | 1 1 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 | Hyperplasia, Lymphoid | 2 2 2 2 | Endothelium, Hyperplasia | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + I + + M + + + + M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Skin | + + + + + + + + + M + + + + + + + + + + + + + + +| Sebaceous Gland, Hyperplasia | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 2| DAY ON TEST | 2| 2| 2| 2| 5| 2| 2| 0| 2| 6| 2| 3| 3| 2| 2| 5| 2| 2| 4| 3| 3| 3| 0| 5| 3| | 9| 9| 9| 9| 3| 9| 9| 3| 9| 2| 9| 0| 0| 9| 9| 3| 9| 9| 9| 0| 2| 0| 1| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Inflammation, Chronic Active | 1 | Alveolar Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 1 1 | Glands, Inflammation, Acute | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Metaplasia, Osseous | 1 | Renal Tubule, Regeneration | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | Inflammation, Chronic | 1 1 | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 4| 7| 4| 7| 7| 7| 4| DAY ON TEST | 3| 0| 3| 5| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 5| 3| 5| 3| 3| 3| 5| | 2| 3| 0| 3| 0| 7| 0| 2| 2| 0| 0| 2| 0| 0| 0| 0| 1| 2| 3| 2| 0| 0| 0| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + M + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + M M + + + + + + + + + + + + + + + + + + +| Autolysis | | Inflammation, Chronic | 1 | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Pigmentation | 1 1 1 1 1| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Pigmentation | 1 1 1| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia, Lymphoid | | Epithelium, Pigmentation | 1 1 1 1 2| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Epithelium, Pigmentation | 1 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | | Eosinophilic Focus | 2 1 | Inflammation, Acute | 1 | Inflammation, Chronic | 1 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Mixed Cell Focus | 2 | Necrosis, Coagulative | 1 | __________________________________________________________________________| Mesentery | + | Fibrosis | 2 | Hemorrhage | | Inflammation, Chronic Active | 1 | Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Parotid Gland, Atrophy | | Parotid Gland, Inflammation, Chronic | 2 | Sublingual Gland, Inflammation, | | Chronic | 1 | Submandibular Gland, Inflammation, | | Chronic | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 | __________________________________________________________________________| Stomach | + + M + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 4| 7| 4| 7| 7| 7| 4| DAY ON TEST | 3| 0| 3| 5| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 5| 3| 5| 3| 3| 3| 5| | 2| 3| 0| 3| 0| 7| 0| 2| 2| 0| 0| 2| 0| 0| 0| 0| 1| 2| 3| 2| 0| 0| 0| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Stomach, Forestomach | + + M + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 | Hyperkeratosis | 2 | Hyperplasia, Basal Cell | | Inflammation, Chronic Active | 1 | Ulcer, Acute | | __________________________________________________________________________| Stomach, Glandular | + + M + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Mineralization | | Epithelium, Hyperplasia | 2 2 | Epithelium, Pigmentation | 1 1 1 1 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | | Inflammation, Chronic Active | | Endothelium, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + M + + M + + + + + + M + M + + M M M M + + M + M| Inflammation, Chronic | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 1 | Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 2 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 2 1 1 | Ultimobranchial Cyst | X | C-Cell, Hyperplasia | | Follicular Cell, Hyperplasia | 2 1 1 3 1 1 4 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Hemorrhage | 3 | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + | Cyst, Multiple | 2 | Pigmentation | 1 1 1 | _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 4| 7| 4| 7| 7| 7| 4| DAY ON TEST | 3| 0| 3| 5| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 5| 3| 5| 3| 3| 3| 5| | 2| 3| 0| 3| 0| 7| 0| 2| 2| 0| 0| 2| 0| 0| 0| 0| 1| 2| 3| 2| 0| 0| 0| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Duct, Dilatation | 1 2 | __________________________________________________________________________| Ovary | + + + + + M + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 3 3 2 1 2 1 | Hemorrhage | 1 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hydrometra | 3 2 2 4 3 2 4 3 2 | Thrombosis | | Endometrium, Hyperplasia | 2 2 2 4 2 2 2 2 2 2 2 3 2 2 2 2 3 2 2 2 2 2 3| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Sternal, Myelofibrosis | 1 1 2 1 1 1 2 2 1 2 1 1 1 1 1 2 2 1 2 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Hyperplasia, Lymphoid | 1 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Depletion Lymphoid | | Infiltration Cellular, Histiocyte | 1 | Pigmentation | 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | Hyperplasia, Lymphoid | 2 | Endothelium, Hyperplasia | 1 | __________________________________________________________________________| Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + M + + + + + + + + + + + + + M + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Sebaceous Gland, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 4| 7| 4| 7| 7| 7| 4| DAY ON TEST | 3| 0| 3| 5| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 5| 3| 5| 3| 3| 3| 5| | 2| 3| 0| 3| 0| 7| 0| 2| 2| 0| 0| 2| 0| 0| 0| 0| 1| 2| 3| 2| 0| 0| 0| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Inflammation, Chronic Active | | Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 1 1 1 1 1 1 | Glands, Inflammation, Acute | | __________________________________________________________________________| Trachea | + + + + + + + + + + + M + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Metaplasia, Osseous | | Renal Tubule, Regeneration | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Inflammation, Chronic | 1 1 1 1| _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 3| 2| 5| 3| 3| 5| 3| 3| 3| 3| | | | 0| 9| 3| 0| 0| 0| 0| 0| 0| 0| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | A | 50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L | PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 57 | Autolysis | | 1 3.0| Inflammation, Chronic | 1 | 3 1.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | Epithelium, Pigmentation | 1 1 | 10 1.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | Epithelium, Pigmentation | 1 | 6 1.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | Autolysis | | 1 4.0| Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 59 | Autolysis | | 1 3.0| Hyperplasia, Lymphoid | 2 | 3 2.7| Epithelium, Pigmentation | 1 1 | 9 1.2| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | Autolysis | | 1 4.0| Epithelium, Pigmentation | | 2 1.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Clear Cell Focus | 1 1 | 2 1.0| Eosinophilic Focus | 1 1 | 8 1.4| Inflammation, Acute | | 1 1.0| Inflammation, Chronic | 1 | 3 1.0| Inflammation, Chronic Active | 1 1 1 1 1 1 1 | 37 1.0| Mixed Cell Focus | | 1 2.0| Necrosis, Coagulative | | 2 1.0| __________________________________________________________________________|____________| Mesentery | | 4 | Fibrosis | | 3 1.3| Hemorrhage | | 1 1.0| Inflammation, Chronic Active | | 3 1.0| Necrosis | | 3 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Inflammation, Chronic | 1 | 4 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | Parotid Gland, Atrophy | | 1 1.0| Parotid Gland, Inflammation, Chronic | | 3 1.7| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 3| 2| 5| 3| 3| 5| 3| 3| 3| 3| | | | 0| 9| 3| 0| 0| 0| 0| 0| 0| 0| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | A | 50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L | PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Sublingual Gland, Inflammation, | | | Chronic | 1 | 4 1.0| Submandibular Gland, Inflammation, | | | Chronic | 1 1 1 1 2 1 1 1 1 | 50 1.2| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 59 | Acanthosis | 1 | 4 1.5| Hyperkeratosis | 1 | 4 1.3| Hyperplasia, Basal Cell | | 1 2.0| Inflammation, Chronic Active | 1 | 3 1.0| Ulcer, Acute | | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 59 | Inflammation, Chronic Active | | 1 2.0| Mineralization | | 2 1.0| Epithelium, Hyperplasia | | 2 2.0| Epithelium, Pigmentation | 1 1 | 9 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Cardiomyopathy | 1 | 1 1.0| Inflammation, Chronic Active | | 1 1.0| Endothelium, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + M + + + | 59 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + M + + + | 59 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + M + I + | 55 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 57 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | M I M M M + M + M M | 30 | Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + M + + + + | 59 | Pars Distalis, Angiectasis | 1 | 3 1.3| Pars Distalis, Cyst | | 1 1.0| Pars Distalis, Hyperplasia | | 2 1.5| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 59 | Inflammation, Chronic Active | 1 | 9 1.2| Ultimobranchial Cyst | X | 2 | C-Cell, Hyperplasia | | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 48 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 3| 2| 5| 3| 3| 5| 3| 3| 3| 3| | | | 0| 9| 3| 0| 0| 0| 0| 0| 0| 0| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | A | 50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L | PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Follicular Cell, Hyperplasia | 2 1 | 16 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | Hemorrhage | | 1 3.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + | 7 | Cyst, Multiple | 2 | 2 2.0| Pigmentation | 1 | 4 1.0| Duct, Dilatation | 2 1 | 4 1.5| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 58 | Cyst | 1 2 3 2 1 2 | 22 2.1| Hemorrhage | 1 | 3 1.3| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 60 | Angiectasis | 3 | 1 3.0| Hydrometra | 1 3 2 | 24 2.7| Thrombosis | 3 | 1 3.0| Endometrium, Hyperplasia | 1 1 2 2 1 3 2 2 1 1 | 50 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Sternal, Myelofibrosis | 2 2 1 2 1 1 1 | 37 1.5| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 60 | Mandibular, Hyperplasia, Lymphoid | | 2 1.5| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 59 | Angiectasis | 1 | 1 1.0| Depletion Lymphoid | | 1 3.0| Infiltration Cellular, Histiocyte | 1 | 5 1.0| Pigmentation | 1 | 5 1.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Hematopoietic Cell Proliferation | | 2 2.0| Hyperplasia, Lymphoid | | 5 2.0| Endothelium, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 56 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 57 | Hyperplasia | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 49 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 3| 2| 5| 3| 3| 5| 3| 3| 3| 3| | | | 0| 9| 3| 0| 0| 0| 0| 0| 0| 0| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | A | 50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L | PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 59 | Sebaceous Gland, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + | 59 | __________________________________________________________________________|____________| Skeletal Muscle | | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Thalamus, Mineralization | 1 1 1 1 1 1 1 1 | 50 1.0| __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Inflammation, Chronic Active | | 1 1.0| Alveolar Epithelium, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | Inflammation, Acute | 1 1 1 | 11 1.0| Glands, Inflammation, Acute | | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 59 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Harderian Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Hemorrhage | 4 | 1 4.0| Inflammation, Chronic | 1 2 2 1 2 2 1 1 1 | 57 1.1| Metaplasia, Osseous | | 1 1.0| Renal Tubule, Regeneration | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | Autolysis | | 1 3.0| Inflammation, Chronic | 1 | 7 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 50 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 6| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7| DAY ON TEST | 1| 2| 2| 2| 2| 2| 5| 2| 5| 5| 2| 2| 0| 2| 2| 2| 2| 5| 5| 6| 2| 2| 2| 1| 2| | 8| 9| 9| 9| 9| 9| 7| 9| 5| 5| 9| 9| 9| 9| 9| 9| 9| 7| 5| 4| 9| 9| 9| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + M + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Gallbladder | + M M + + M + + + + + + + M + + + + + M M + + + +| Inflammation, Acute | | Inflammation, Chronic | 1 | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia, Lymphoid | 1 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia, Lymphoid | 1 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | 3 | Clear Cell Focus | | Cyst Multilocular | | Eosinophilic Focus | 1 1 2 | Fatty Change | 2 1 1 1 2 2 2 1 2 2 1 2 1 1 2 1 2 1| Inflammation, Acute | 1 | Inflammation, Chronic Active | 2 | Mixed Cell Focus | | Necrosis, Coagulative | 1 | Necrosis | 1 1 | __________________________________________________________________________| Mesentery | + + | Fibrosis | 1 | Hemorrhage | 2 | Inflammation, Chronic | 1 | Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration | 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Sublingual Gland, Inflammation, | | Chronic | | Submandibular Gland, Inflammation, | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1| _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 6| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7| DAY ON TEST | 1| 2| 2| 2| 2| 2| 5| 2| 5| 5| 2| 2| 0| 2| 2| 2| 2| 5| 5| 6| 2| 2| 2| 1| 2| | 8| 9| 9| 9| 9| 9| 7| 9| 5| 5| 9| 9| 9| 9| 9| 9| 9| 7| 5| 4| 9| 9| 9| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Submandibular Gland, Inflammation | 1 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 | Inflammation, Chronic | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | Mineralization | | __________________________________________________________________________| Tongue | + | Hemorrhage | 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + M + + + M + M + M + + + + + +| Cyst | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Follicle, Cyst | 1 | Follicle, Cyst, Multiple | | Follicular Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 | Inflammation, Chronic Active | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + | Cyst | 3 | Cyst, Multiple | | Inflammation, Chronic | 1 | Inflammation, Chronic Active | 3 1 1 1 2 1 | _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 6| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7| DAY ON TEST | 1| 2| 2| 2| 2| 2| 5| 2| 5| 5| 2| 2| 0| 2| 2| 2| 2| 5| 5| 6| 2| 2| 2| 1| 2| | 8| 9| 9| 9| 9| 9| 7| 9| 5| 5| 9| 9| 9| 9| 9| 9| 9| 7| 5| 4| 9| 9| 9| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Duct, Dilatation | 3 3 3 3 2 3 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + M + + + + + + + + + + + + + + + + + + +| Mediastinal, Angiectasis | | Pancreatic, Hyperplasia, Lymphoid | 2 | Pancreatic, Hyperplasia, Plasma Cell | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 | Hyperplasia, Lymphoid | | Infiltration Cellular, Histiocyte | 1 1 1 1 | Pigmentation | 1 1 1 1 | Polyarteritis | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | | __________________________________________________________________________| Thymus | M + + + + M + + + + + + M + M + + + + M + + + + +| Cyst | 1 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + M + + + I + + + +| Cyst Epithelial Inclusion | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 2 | Alveolar Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Nose | + + + + + + + + M + + + + + + + + + + + + + + + +| Inflammation, Acute | 1 1 1 | Glands, Inflammation, Acute | 1 | _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 6| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7| DAY ON TEST | 1| 2| 2| 2| 2| 2| 5| 2| 5| 5| 2| 2| 0| 2| 2| 2| 2| 5| 5| 6| 2| 2| 2| 1| 2| | 8| 9| 9| 9| 9| 9| 7| 9| 5| 5| 9| 9| 9| 9| 9| 9| 9| 7| 5| 4| 9| 9| 9| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Metaplasia, Osseous | | Renal Tubule, Mineralization | 1 | Renal Tubule, Regeneration | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Calculus Gross Observation | X | Fibrosis | 3 | Inflammation, Chronic | 1 | Inflammation, Chronic Active | 4 | Ulcer | 3 | Transitional Epithelium, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| Page 54 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 1| 4| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| DAY ON TEST | 3| 2| 2| 2| 3| 3| 5| 2| 2| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 5| 5| 3| 2| 3| 2| | 4| 9| 9| 9| 0| 0| 5| 9| 9| 0| 0| 9| 5| 0| 0| 0| 0| 0| 0| 7| 7| 0| 9| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 2 | Inflammation, Chronic | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Clear Cell Focus | 1 1 1 1 1 | Cyst Multilocular | 2 | Eosinophilic Focus | 1 2 | Fatty Change | 1 2 1 1 1 1 2 2 2 1 1| Inflammation, Acute | 1 | Inflammation, Chronic Active | 1 | Mixed Cell Focus | | Necrosis, Coagulative | 1 | Necrosis | | __________________________________________________________________________| Mesentery | + + + | Fibrosis | 2 | Hemorrhage | 2 3 | Inflammation, Chronic | 1 | Necrosis | 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Sublingual Gland, Inflammation, | | Chronic | 1 | Submandibular Gland, Inflammation, | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| Page 55 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 1| 4| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| DAY ON TEST | 3| 2| 2| 2| 3| 3| 5| 2| 2| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 5| 5| 3| 2| 3| 2| | 4| 9| 9| 9| 0| 0| 5| 9| 9| 0| 0| 9| 5| 0| 0| 0| 0| 0| 0| 7| 7| 0| 9| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Submandibular Gland, Inflammation | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 | Mineralization | 1 | __________________________________________________________________________| Tongue | | Hemorrhage | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 1 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + M + + + M + M + + M M + + + M + M M M M + M| Cyst | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Follicle, Cyst | | Follicle, Cyst, Multiple | 2 | Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 | Inflammation, Chronic Active | 1 1 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + | Cyst | | Cyst, Multiple | 3 4 | Inflammation, Chronic | 1 | Inflammation, Chronic Active | 1 1 1 1 | _____________________________________________________________________________________________________________________| Page 56 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 1| 4| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| DAY ON TEST | 3| 2| 2| 2| 3| 3| 5| 2| 2| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 5| 5| 3| 2| 3| 2| | 4| 9| 9| 9| 0| 0| 5| 9| 9| 0| 0| 9| 5| 0| 0| 0| 0| 0| 0| 7| 7| 0| 9| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Duct, Dilatation | 2 2 2 2 2 2 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 | Inflammation, Chronic Active | 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + M + + + + + + M + + + + + + +| Mediastinal, Angiectasis | 2 1 | Pancreatic, Hyperplasia, Lymphoid | | Pancreatic, Hyperplasia, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + M + + + + + + +| Angiectasis | 1 1 | Hyperplasia, Lymphoid | 4 | Infiltration Cellular, Histiocyte | 1 1 1 | Pigmentation | 1 1 1 | Polyarteritis | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 3 2 2 | __________________________________________________________________________| Thymus | M + + I + + + + + + + M + + + + + + + + M M + + +| Cyst | 1 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 1 | Alveolar Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Nose | + + + + + + M + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 1 | Glands, Inflammation, Acute | | _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 1| 4| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| DAY ON TEST | 3| 2| 2| 2| 3| 3| 5| 2| 2| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 5| 5| 3| 2| 3| 2| | 4| 9| 9| 9| 0| 0| 5| 9| 9| 0| 0| 9| 5| 0| 0| 0| 0| 0| 0| 7| 7| 0| 9| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + M + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | + + + | __________________________________________________________________________| Harderian Gland | + + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Metaplasia, Osseous | | Renal Tubule, Mineralization | 1 1 1 1 | Renal Tubule, Regeneration | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | Calculus Gross Observation | | Fibrosis | | Inflammation, Chronic | 1 1 | Inflammation, Chronic Active | | Ulcer | | Transitional Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| | | DAY ON TEST | 7| 2| 2| 2| 2| 2| 2| 2| 5| 2| | | | 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | 0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Gallbladder | M + + + + + + + + + | 53 | Inflammation, Acute | | 1 2.0| Inflammation, Chronic | | 1 1.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | Autolysis | | 1 3.0| Hyperplasia, Lymphoid | | 1 1.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | Autolysis | | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | Autolysis | | 1 3.0| __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | Autolysis | | 1 3.0| Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 60 | Autolysis | | 1 3.0| Hyperplasia, Lymphoid | | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | Autolysis | | 1 3.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Basophilic Focus | | 1 3.0| Clear Cell Focus | 2 1 1 1 1 | 10 1.1| Cyst Multilocular | | 1 2.0| Eosinophilic Focus | 3 | 6 1.7| Fatty Change | 2 1 1 2 | 33 1.5| Inflammation, Acute | | 2 1.0| Inflammation, Chronic Active | | 2 1.5| Mixed Cell Focus | 2 | 1 2.0| Necrosis, Coagulative | | 2 1.0| Necrosis | 1 | 3 1.0| __________________________________________________________________________|____________| Mesentery | | 5 | Fibrosis | | 2 1.5| Hemorrhage | | 3 2.3| Inflammation, Chronic | | 2 1.0| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Cytoplasmic Alteration | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 59 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| | | DAY ON TEST | 7| 2| 2| 2| 2| 2| 2| 2| 5| 2| | | | 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | 0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | Sublingual Gland, Inflammation, | | | Chronic | 1 | 2 1.0| Submandibular Gland, Inflammation, | | | Chronic | 1 1 1 1 1 1 1 | 43 1.0| Submandibular Gland, Inflammation | | 1 1.0| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Hyperplasia | | 2 1.5| Inflammation, Chronic | | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Inflammation, Chronic | | 1 1.0| Mineralization | | 1 1.0| __________________________________________________________________________|____________| Tongue | | 1 | Hemorrhage | | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Inflammation, Chronic Active | | 3 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 60 | Hyperplasia | 1 | 6 1.5| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | Hyperplasia | 1 | 2 1.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + M + | 43 | Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 60 | Pars Distalis, Cyst | | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | Inflammation, Chronic Active | | 1 1.0| Follicle, Cyst | | 1 1.0| Follicle, Cyst, Multiple | | 1 2.0| Follicular Cell, Hyperplasia | | 2 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 60 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| | | DAY ON TEST | 7| 2| 2| 2| 2| 2| 2| 2| 5| 2| | | | 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | 0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | Inflammation, Chronic | | 3 1.0| Inflammation, Chronic Active | | 2 1.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + | 25 | Cyst | | 1 3.0| Cyst, Multiple | 3 | 3 3.3| Inflammation, Chronic | | 2 1.0| Inflammation, Chronic Active | 2 3 1 | 13 1.5| Duct, Dilatation | 2 2 2 2 3 | 19 2.3| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 60 | Inflammation, Chronic | 1 | 6 1.0| Inflammation, Chronic Active | 3 | 3 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + | 50 | Fibrosis | | 2 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 57 | Mediastinal, Angiectasis | | 2 1.5| Pancreatic, Hyperplasia, Lymphoid | | 1 2.0| Pancreatic, Hyperplasia, Plasma Cell | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 56 | Angiectasis | 1 1 | 6 1.0| Hyperplasia, Lymphoid | | 1 4.0| Infiltration Cellular, Histiocyte | | 7 1.0| Pigmentation | | 7 1.0| Polyarteritis | | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Depletion Lymphoid | | 3 2.3| __________________________________________________________________________|____________| Thymus | + + + + + + + M + M | 48 | Cyst | | 2 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 58 | Cyst Epithelial Inclusion | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 61 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| | | DAY ON TEST | 7| 2| 2| 2| 2| 2| 2| 2| 5| 2| | | | 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | 0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Thalamus, Mineralization | 1 1 1 1 1 1 1 1 | 48 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Infiltration Cellular, Histiocyte | | 2 1.5| Alveolar Epithelium, Hyperplasia | 1 1 | 4 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 58 | Inflammation, Acute | | 4 1.0| Glands, Inflammation, Acute | | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 59 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 2 | __________________________________________________________________________|____________| Eye | + | 4 | __________________________________________________________________________|____________| Harderian Gland | + | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 | 56 1.0| Metaplasia, Osseous | 1 | 1 1.0| Renal Tubule, Mineralization | 1 | 6 1.0| Renal Tubule, Regeneration | | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | Autolysis | | 1 3.0| Calculus Gross Observation | X | 2 | Fibrosis | | 1 3.0| Inflammation, Chronic | | 3 1.0| Inflammation, Chronic Active | | 1 4.0| Ulcer | | 1 3.0| Transitional Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 62 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 4| 4| 7| 6| 7| 7| 4| 7| DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 9| 3| 3| 5| 5| 3| 9| 3| 3| 5| 3| | 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 5| 7| 7| 5| 3| 7| 6| 7| 7| 7| 1| 7| 7| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | M + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + M + + + + + + + + M + + + + +| Autolysis | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 2 | Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 2 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + M + + + + + + + + + +| Autolysis | 2 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 2 | Hyperplasia, Lymphoid | 1| Inflammation, Chronic Active | 3 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 2 | Hyperplasia, Lymphoid | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Autolysis | 2 | Basophilic Focus | 2 | Clear Cell Focus | 1 1 | Eosinophilic Focus | 1 1 1 1 1 | Fatty Change | 1 1 1 1 1 2 2 3 1 3 1| Hematopoietic Cell Proliferation | 1 | Inflammation, Chronic Active | 1 1 1| Mixed Cell Focus | | Necrosis, Coagulative | 1 | Necrosis | 1 1 1 | __________________________________________________________________________| Mesentery | + + | Angiectasis | | Fibrosis | 1 | Hemorrhage | 2 | Inflammation, Chronic Active | 1 | Necrosis | 1 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration | 1 | Inflammation, Chronic Active | 2 2| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + M + + + + + + +| Parotid Gland, Inflammation, Chronic | 1 | Submandibular Gland, Inflammation, | | _____________________________________________________________________________________________________________________| Page 63 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 4| 4| 7| 6| 7| 7| 4| 7| DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 9| 3| 3| 5| 5| 3| 9| 3| 3| 5| 3| | 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 5| 7| 7| 5| 3| 7| 6| 7| 7| 7| 1| 7| 7| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + M + + + + + + + + + + +| Acanthosis | 1 | Hyperkeratosis | 1 | Mineralization | | Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | Inflammation, Chronic Active | 1 2 2 | Mineralization | | Mucosa, Mineralization | | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 2| Mineralization | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1| __________________________________________________________________________| Adrenal Gland, Medulla | + M + M I M + + M + + + M + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + + + + + M + M M + M M M M + M M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + M + + + + + +| Pars Distalis, Cyst | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + +| Cyst | | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2| __________________________________________________________________________| Preputial Gland | + + + + + + + | Cyst, Multiple | | Inflammation, Chronic Active | 1 2 1 1 2 1 1 | Pigmentation | | _____________________________________________________________________________________________________________________| Page 64 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 4| 4| 7| 6| 7| 7| 4| 7| DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 9| 3| 3| 5| 5| 3| 9| 3| 3| 5| 3| | 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 5| 7| 7| 5| 3| 7| 6| 7| 7| 7| 1| 7| 7| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Duct, Dilatation | 2 3 2 3 3 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 | Inflammation, Chronic Active | 1| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + +| Lumbar, Hyperplasia, Lymphoid | 2 | Mandibular, Hyperplasia, Lymphoid | | Mandibular, Hyperplasia, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Hyperplasia, Lymphoid | 2 2| Hyperplasia, Plasma Cell | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 4 2 | Hyperplasia, Lymphoid | 2| __________________________________________________________________________| Thymus | + + + + + + + + + + + M + + + + + + +| Hyperplasia, Lymphoid | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + I I + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2| Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 1 2 | Inflammation, Chronic Active | 2| Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 65 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 4| 4| 7| 6| 7| 7| 4| 7| DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 9| 3| 3| 5| 5| 3| 9| 3| 3| 5| 3| | 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 5| 7| 7| 5| 3| 7| 6| 7| 7| 7| 1| 7| 7| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Inflammation, Acute | 1 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + + + | Cornea, Inflammation, Chronic Active | 1 | __________________________________________________________________________| Harderian Gland | + + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 2| Medulla, Foreign Body | 1 | Renal Tubule, Atrophy | 3 3 | Renal Tubule, Degeneration, Hyaline | 2 | Renal Tubule, Regeneration | 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | | Inflammation, Chronic Active | 1| _____________________________________________________________________________________________________________________| Page 66 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 5| | 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + M + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + | Autolysis | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia, Lymphoid | 2 2 | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia, Lymphoid | 1 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Autolysis | | Basophilic Focus | | Clear Cell Focus | 1 2 | Eosinophilic Focus | 1 2 | Fatty Change | 1 1 1 3 2 2 1 3 1 1 2| Hematopoietic Cell Proliferation | | Inflammation, Chronic Active | 1 1 | Mixed Cell Focus | 1 1 | Necrosis, Coagulative | 1 | Necrosis | 2 1 1 | __________________________________________________________________________| Mesentery | + + + + + + | Angiectasis | 2 | Fibrosis | | Hemorrhage | 2 2 2 2 2 | Inflammation, Chronic Active | | Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + | Cytoplasmic Alteration | | Inflammation, Chronic Active | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + M + + + + + + + + + + + +| Parotid Gland, Inflammation, Chronic | | Submandibular Gland, Inflammation, | | _____________________________________________________________________________________________________________________| Page 67 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 5| | 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Chronic | 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Hyperkeratosis | | Mineralization | 1 1 | Epithelium, Hyperplasia | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | Inflammation, Chronic Active | 1 | Mineralization | | Mucosa, Mineralization | 1 | __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | | Mineralization | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + | Hyperplasia | 1 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + M M + + + + + + + + + + + + + + + + + | Hyperplasia | 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + | Hyperplasia | 1 | __________________________________________________________________________| Parathyroid Gland | + + + M M + M + M + + M + + + + M M + + + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + | Pars Distalis, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + | Cyst | | Follicular Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | | __________________________________________________________________________| Preputial Gland | M + M + + + + + + + + + + + + +| Cyst, Multiple | 3 3 3 4| Inflammation, Chronic Active | 1 2 1 1 2 1 | Pigmentation | 1 | _____________________________________________________________________________________________________________________| Page 68 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 5| | 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Duct, Dilatation | 3 2 2 2 2 3 2 2 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic | | Inflammation, Chronic Active | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + | Lumbar, Hyperplasia, Lymphoid | | Mandibular, Hyperplasia, Lymphoid | | Mandibular, Hyperplasia, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + | Angiectasis | 2 | Hyperplasia, Lymphoid | 2 | Hyperplasia, Plasma Cell | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + | Hematopoietic Cell Proliferation | | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + I | Hyperplasia, Lymphoid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M | __________________________________________________________________________| Skin | + I + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | | Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + | Infiltration Cellular, Histiocyte | 1 | Inflammation, Chronic Active | | Alveolar Epithelium, Hyperplasia | 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + M + + + | _____________________________________________________________________________________________________________________| Page 69 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 5| | 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Inflammation, Acute | 1 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | | Cornea, Inflammation, Chronic Active | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Medulla, Foreign Body | | Renal Tubule, Atrophy | 1 | Renal Tubule, Degeneration, Hyaline | | Renal Tubule, Regeneration | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + | Calculus Micro Observation Only | X | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| Page 70 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| | | DAY ON TEST | 3| 3| 0| 3| 3| 7| 1| 3| 3| 6| | | | 7| 7| 7| 7| 7| 9| 5| 7| 7| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + M M + I + + + + + | 44 | __________________________________________________________________________|____________| Gallbladder | + + + + + I + + + + | 47 | Autolysis | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | Autolysis | 2 | 2 2.0| Hyperplasia, Lymphoid | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | Autolysis | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 59 | Autolysis | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 60 | Autolysis | 4 | 2 3.0| Hyperplasia, Lymphoid | | 3 1.7| Inflammation, Chronic Active | | 2 2.5| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | Autolysis | | 1 2.0| Hyperplasia, Lymphoid | | 1 1.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 59 | Angiectasis | | 1 2.0| Autolysis | | 1 2.0| Basophilic Focus | 1 | 2 1.5| Clear Cell Focus | 2 | 5 1.4| Eosinophilic Focus | 2 | 8 1.3| Fatty Change | 1 | 23 1.6| Hematopoietic Cell Proliferation | | 1 1.0| Inflammation, Chronic Active | | 5 1.0| Mixed Cell Focus | | 2 1.0| Necrosis, Coagulative | | 2 1.0| Necrosis | | 6 1.2| __________________________________________________________________________|____________| Mesentery | + + | 10 | Angiectasis | | 1 2.0| Fibrosis | | 1 1.0| Hemorrhage | 2 2 | 8 2.0| Inflammation, Chronic Active | | 1 1.0| Necrosis | | 1 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 71 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| | | DAY ON TEST | 3| 3| 0| 3| 3| 7| 1| 3| 3| 6| | | | 7| 7| 7| 7| 7| 9| 5| 7| 7| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Cytoplasmic Alteration | | 1 1.0| Inflammation, Chronic Active | | 2 2.0| __________________________________________________________________________|____________| Salivary Glands | + M + + + + + + + + | 49 | Parotid Gland, Inflammation, Chronic | | 1 1.0| Submandibular Gland, Inflammation, | | | Chronic | 1 1 1 1 1 2 | 34 1.1| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 59 | Acanthosis | | 1 1.0| Hyperkeratosis | | 1 1.0| Mineralization | | 2 1.0| Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Erosion | 1 | 1 1.0| Inflammation, Chronic Active | | 4 1.5| Mineralization | 1 | 1 1.0| Mucosa, Mineralization | | 1 1.0| __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 50 | Inflammation, Chronic Active | 1 | 3 1.3| Mineralization | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 50 | Hyperplasia | 1 | 5 1.4| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 42 | Hyperplasia | | 2 1.5| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 50 | Hyperplasia | | 2 1.5| __________________________________________________________________________|____________| Parathyroid Gland | + M M M M M M + + M | 27 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 49 | Pars Distalis, Cyst | | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + M + + + + + + + + | 49 | Cyst | 1 | 1 1.0| Follicular Cell, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 72 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| | | DAY ON TEST | 3| 3| 0| 3| 3| 7| 1| 3| 3| 6| | | | 7| 7| 7| 7| 7| 9| 5| 7| 7| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 50 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + | 24 | Cyst, Multiple | | 4 3.3| Inflammation, Chronic Active | | 13 1.3| Pigmentation | | 1 1.0| Duct, Dilatation | 2 2 2 | 18 2.3| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 50 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 51 | Inflammation, Chronic | | 1 1.0| Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 50 | Inflammation, Chronic Active | | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | | 1 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 50 | __________________________________________________________________________|____________| Lymph Node | + M + + + + + + + + | 51 | Lumbar, Hyperplasia, Lymphoid | | 1 2.0| Mandibular, Hyperplasia, Lymphoid | 2 | 1 2.0| Mandibular, Hyperplasia, Plasma Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + M + + + + I + + + | 50 | Angiectasis | 2 | 3 1.7| Hyperplasia, Lymphoid | | 3 2.0| Hyperplasia, Plasma Cell | | 2 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 50 | Hematopoietic Cell Proliferation | 2 | 3 2.7| Hyperplasia, Lymphoid | | 2 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + M + + + | 47 | Hyperplasia, Lymphoid | | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 47 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 73 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| | | DAY ON TEST | 3| 3| 0| 3| 3| 7| 1| 3| 3| 6| | | | 7| 7| 7| 7| 7| 9| 5| 7| 7| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 50 | Inflammation, Chronic Active | | 1 2.0| Thalamus, Mineralization | 1 1 1 1 1 1 | 30 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 50 | Infiltration Cellular, Histiocyte | | 3 1.3| Inflammation, Chronic Active | | 1 2.0| Alveolar Epithelium, Hyperplasia | | 2 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 49 | Inflammation, Acute | 1 | 7 1.0| __________________________________________________________________________|____________| Trachea | + M + + + + + + + + | 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Eye | M + | 4 | Cornea, Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Harderian Gland | + | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 53 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 | 47 1.1| Medulla, Foreign Body | | 1 1.0| Renal Tubule, Atrophy | | 3 2.3| Renal Tubule, Degeneration, Hyaline | | 1 2.0| Renal Tubule, Regeneration | 1 1 | 4 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 50 | Calculus Micro Observation Only | | 1 | Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 74 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 4| DAY ON TEST | 3| 3| 1| 4| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 4| 3| 4| 5| | 4| 5| 3| 1| 7| 4| 4| 4| 5| 5| 5| 4| 4| 4| 3| 5| 4| 4| 4| 5| 5| 1| 4| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Gallbladder | + + + M M + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | | Eosinophilic Focus | 2 2 | Fatty Change | 1 3 1 1 2 2 3 3 1 2 1 1 1 3| Hematopoietic Cell Proliferation | | Inflammation, Chronic Active | | Mixed Cell Focus | | Necrosis, Coagulative | | Necrosis | 1 | __________________________________________________________________________| Mesentery | + | Fibrosis | 1 | Hemorrhage | 2 | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + | Autolysis | 1 | Cytoplasmic Alteration | | Inflammation, Chronic Active | 4 | Acinus, Atrophy | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + | Parotid Gland, Inflammation, Chronic | | Sublingual Gland, Inflammation, | | Chronic | | Submandibular Gland, Inflammation, | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 1 | Hyperkeratosis | 1 1 | Hyperplasia, Basal Cell | 1 1 | Inflammation, Chronic Active | 1 1 2 | _____________________________________________________________________________________________________________________| Page 75 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 4| DAY ON TEST | 3| 3| 1| 4| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 4| 3| 4| 5| | 4| 5| 3| 1| 7| 4| 4| 4| 5| 5| 5| 4| 4| 4| 3| 5| 4| 4| 4| 5| 5| 1| 4| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Ulcer | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | Inflammation, Chronic Active | | Mineralization | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + M + + + + + + + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + M + + + + + + + + | Hyperplasia | 1 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + M + + + M + M + + + + M M + + + + + + + | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Parathyroid Gland | M + + M M + + + M + + + + + + + + + + + M | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + | Pars Distalis, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + | Cyst Multilocular | 2 | Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + +| Cyst, Multiple | 2 3 4 4| Inflammation, Chronic | 2 1 2 | Inflammation, Chronic Active | 1 1 1 2 1| Duct, Dilatation | 2 2 2 3 2 2 2 2 2 2 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + | Seminiferous Tubule, Atrophy | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + | Myeloid Cell, Sternal, Hyperplasia | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + M | _____________________________________________________________________________________________________________________| Page 76 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 4| DAY ON TEST | 3| 3| 1| 4| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 4| 3| 4| 5| | 4| 5| 3| 1| 7| 4| 4| 4| 5| 5| 5| 4| 4| 4| 3| 5| 4| 4| 4| 5| 5| 1| 4| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Mandibular, Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M | Hyperplasia, Lymphoid | 2 | Infiltration Cellular, Histiocyte | | Inflammation, Granulomatous | 4 | Pigmentation | | Sinus, Ectasia | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + | Angiectasis | | Depletion Lymphoid | | Hematopoietic Cell Proliferation | 2 3 3 | Hyperplasia, Lymphoid | 2 | Inflammation, Granulomatous | 2 | __________________________________________________________________________| Thymus | + M M M + + + + + M + + + + + + + + M + + | Cyst | 1 | Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M A M M M M M M M M M | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + | Parakeratosis | | Ulcer | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + M + + + + + + + + + + + + + + + + | Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | 3 | Leukocytosis | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Acute | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Cornea, Inflammation, Chronic Active | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 77 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 4| DAY ON TEST | 3| 3| 1| 4| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 4| 3| 4| 5| | 4| 5| 3| 1| 7| 4| 4| 4| 5| 5| 5| 4| 4| 4| 3| 5| 4| 4| 4| 5| 5| 1| 4| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + | Cyst | | Glomerulosclerosis | | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 | Renal Tubule, Pigmentation | 1 | Renal Tubule, Regeneration | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + | Calculus Gross Observation | | _____________________________________________________________________________________________________________________| Page 78 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 7| 7| 6| 5| 4| 7| 7| DAY ON TEST | 5| 3| 5| 1| 3| 3| 3| 4| 3| 3| 9| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 9| 5| 3| 3| | 7| 5| 7| 6| 4| 4| 5| 0| 5| 5| 9| 4| 5| 5| 5| 5| 5| 4| 5| 5| 9| 5| 7| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + M + + M + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 4 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 4 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 | Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | 1 1 1 1 1 | Eosinophilic Focus | 1 | Fatty Change | 3 1 1 2 1 2 1 1 1 3 2 2| Hematopoietic Cell Proliferation | 2 | Inflammation, Chronic Active | | Mixed Cell Focus | 2 | Necrosis, Coagulative | | Necrosis | | __________________________________________________________________________| Mesentery | + + | Fibrosis | 1 1 | Hemorrhage | | Inflammation, Chronic Active | 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Cytoplasmic Alteration | | Inflammation, Chronic Active | | Acinus, Atrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| Parotid Gland, Inflammation, Chronic | 2 2 1 1 | Sublingual Gland, Inflammation, | | Chronic | | Submandibular Gland, Inflammation, | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Hyperkeratosis | | Hyperplasia, Basal Cell | | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| Page 79 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 7| 7| 6| 5| 4| 7| 7| DAY ON TEST | 5| 3| 5| 1| 3| 3| 3| 4| 3| 3| 9| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 9| 5| 3| 3| | 7| 5| 7| 6| 4| 4| 5| 0| 5| 5| 9| 4| 5| 5| 5| 5| 5| 4| 5| 5| 9| 5| 7| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 | Inflammation, Chronic Active | | Mineralization | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + M M +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + M M + M + + + + + M + I + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + +| Cyst Multilocular | | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + | Cyst, Multiple | | Inflammation, Chronic | | Inflammation, Chronic Active | 1 2 | Duct, Dilatation | 2 2 2 2 2 2 2 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + +| Seminiferous Tubule, Atrophy | 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + M + + + + + +| Myeloid Cell, Sternal, Hyperplasia | 4 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + M + + + + + M M +| _____________________________________________________________________________________________________________________| Page 80 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 7| 7| 6| 5| 4| 7| 7| DAY ON TEST | 5| 3| 5| 1| 3| 3| 3| 4| 3| 3| 9| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 9| 5| 3| 3| | 7| 5| 7| 6| 4| 4| 5| 0| 5| 5| 9| 4| 5| 5| 5| 5| 5| 4| 5| 5| 9| 5| 7| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Mandibular, Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + M M + + + + M + +| Hyperplasia, Lymphoid | | Infiltration Cellular, Histiocyte | | Inflammation, Granulomatous | | Pigmentation | | Sinus, Ectasia | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Depletion Lymphoid | 2 3 2 | Hematopoietic Cell Proliferation | 2 4 2 | Hyperplasia, Lymphoid | | Inflammation, Granulomatous | | __________________________________________________________________________| Thymus | + + + + + M + + + + + + + + + + + + + M + +| Cyst | 2 | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Parakeratosis | 1 | Ulcer | 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Leukocytosis | 4 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 1 1 | __________________________________________________________________________| Trachea | + + + + + M I + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cornea, Inflammation, Chronic Active | 2 | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 81 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 7| 7| 6| 5| 4| 7| 7| DAY ON TEST | 5| 3| 5| 1| 3| 3| 3| 4| 3| 3| 9| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 9| 5| 3| 3| | 7| 5| 7| 6| 4| 4| 5| 0| 5| 5| 9| 4| 5| 5| 5| 5| 5| 4| 5| 5| 9| 5| 7| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Glomerulosclerosis | 2 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1| Renal Tubule, Pigmentation | | Renal Tubule, Regeneration | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| Calculus Gross Observation | | _____________________________________________________________________________________________________________________| Page 82 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 4| 4| 7| 7| 4| 7| 7| 7| 7| 7| | | DAY ON TEST | 5| 5| 3| 3| 5| 3| 3| 3| 0| 3| | | | 5| 5| 5| 6| 7| 5| 5| 5| 8| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + | 48 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + | 48 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | Ulcer | | 1 4.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | Autolysis | | 2 3.5| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 60 | Autolysis | | 1 4.0| Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Clear Cell Focus | | 5 1.0| Eosinophilic Focus | 2 1 | 5 1.6| Fatty Change | 2 3 1 4 2 1 | 32 1.8| Hematopoietic Cell Proliferation | | 1 2.0| Inflammation, Chronic Active | 1 1 1 | 3 1.0| Mixed Cell Focus | | 1 2.0| Necrosis, Coagulative | 1 | 1 1.0| Necrosis | 1 1 | 3 1.0| __________________________________________________________________________|____________| Mesentery | + | 4 | Fibrosis | | 3 1.0| Hemorrhage | 2 | 2 2.0| Inflammation, Chronic Active | | 3 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + | 50 | Autolysis | | 1 1.0| Cytoplasmic Alteration | 1 | 1 1.0| Inflammation, Chronic Active | | 1 4.0| Acinus, Atrophy | 1 | 2 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + | 50 | Parotid Gland, Inflammation, Chronic | | 4 1.5| Sublingual Gland, Inflammation, | | | Chronic | 2 | 1 2.0| Submandibular Gland, Inflammation, | | | Chronic | 1 2 1 1 | 32 1.0| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 83 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 4| 4| 7| 7| 4| 7| 7| 7| 7| 7| | | DAY ON TEST | 5| 5| 3| 3| 5| 3| 3| 3| 0| 3| | | | 5| 5| 5| 6| 7| 5| 5| 5| 8| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Acanthosis | | 2 1.0| Hyperkeratosis | | 2 1.0| Hyperplasia, Basal Cell | | 2 1.0| Inflammation, Chronic Active | 1 | 4 1.3| Ulcer | | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Inflammation, Chronic | | 1 1.0| Inflammation, Chronic Active | 1 | 1 1.0| Mineralization | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + | 51 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + | 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + | 50 | Hyperplasia | 2 | 5 1.6| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + | 43 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + | 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + M M + M M | 36 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + | 50 | Pars Distalis, Cyst | | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + | 49 | Cyst Multilocular | | 1 2.0| Follicular Cell, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + | 50 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + | 29 | Cyst, Multiple | 3 3 | 6 3.2| Inflammation, Chronic | 1 1 | 5 1.4| Inflammation, Chronic Active | 2 | 8 1.4| Duct, Dilatation | 2 2 | 21 2.0| __________________________________________________________________________|____________| Prostate | + + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 84 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 4| 4| 7| 7| 4| 7| 7| 7| 7| 7| | | DAY ON TEST | 5| 5| 3| 3| 5| 3| 3| 3| 0| 3| | | | 5| 5| 5| 6| 7| 5| 5| 5| 8| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + | 50 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + | 50 | Seminiferous Tubule, Atrophy | | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + | 49 | Myeloid Cell, Sternal, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Lymph Node | + + + + + I + + | 46 | Mandibular, Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + I + + | 46 | Hyperplasia, Lymphoid | 1 1 | 3 1.3| Infiltration Cellular, Histiocyte | 1 | 1 1.0| Inflammation, Granulomatous | | 1 4.0| Pigmentation | 1 | 1 1.0| Sinus, Ectasia | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + | 52 | Angiectasis | | 1 1.0| Depletion Lymphoid | 2 | 4 2.3| Hematopoietic Cell Proliferation | | 6 2.7| Hyperplasia, Lymphoid | | 1 2.0| Inflammation, Granulomatous | | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + M + | 42 | Cyst | 2 | 3 1.7| Inflammation, Chronic Active | | 1 4.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M | | __________________________________________________________________________|____________| Skin | + + + + + + + + | 51 | Parakeratosis | | 1 1.0| Ulcer | | 1 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + | 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + | 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 85 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 4| 4| 7| 7| 4| 7| 7| 7| 7| 7| | | DAY ON TEST | 5| 5| 3| 3| 5| 3| 3| 3| 0| 3| | | | 5| 5| 5| 6| 7| 5| 5| 5| 8| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Thalamus, Mineralization | 1 1 1 1 1 | 31 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + | 50 | Inflammation, Chronic Active | | 1 3.0| Leukocytosis | | 1 4.0| __________________________________________________________________________|____________| Nose | + + + + + + + | 50 | Inflammation, Acute | 1 1 | 5 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Cornea, Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + | 50 | Cyst | 1 | 1 1.0| Glomerulosclerosis | | 1 2.0| Inflammation, Chronic | 1 1 2 1 1 1 1 | 48 1.1| Renal Tubule, Pigmentation | | 1 1.0| Renal Tubule, Regeneration | | 2 1.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + | 50 | Calculus Gross Observation | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 86 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 4| 7| 4| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 4| 4| 7| DAY ON TEST | 5| 3| 5| 3| 3| 7| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5| 5| 3| | 5| 1| 5| 1| 1| 8| 8| 1| 4| 1| 0| 0| 1| 0| 1| 4| 0| 0| 0| 7| 7| 2| 7| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + M + + + + + + + + + + M + + + M + + + + + +| Autolysis | 4 | Inflammation, Chronic | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 | Epithelium, Hyperplasia | 3 | Epithelium, Pigmentation | 1 1 1 1 | Submucosa, Epithelium, Proliferation | 3 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 | Epithelium, Pigmentation | 1 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 | Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 | Hyperplasia, Lymphoid | | Epithelium, Pigmentation | 1 1 1 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 | Hyperplasia, Lymphoid | 2 | Inflammation, Chronic Active | | Epithelium, Pigmentation | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 | Basophilic Focus | | Clear Cell Focus | | Eosinophilic Focus | 2 1 | Fatty Change | 2 4 2 2 1 1 1 1 2 3 4 | Mixed Cell Focus | 1 1 2| Necrosis | | __________________________________________________________________________| Mesentery | + + + + | Fibrosis | 1 2 2 2 | Hemorrhage | | Inflammation, Chronic | 1 | Inflammation, Chronic Active | 1 2 | Necrosis, Coagulative | 3 | Necrosis | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + M + + + +| _____________________________________________________________________________________________________________________| Page 87 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 4| 7| 4| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 4| 4| 7| DAY ON TEST | 5| 3| 5| 3| 3| 7| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5| 5| 3| | 5| 1| 5| 1| 1| 8| 8| 1| 4| 1| 0| 0| 1| 0| 1| 4| 0| 0| 0| 7| 7| 2| 7| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Cytoplasmic Alteration | | Inflammation, Chronic | | Duct, Concretion | | Duct, Dilatation | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Submandibular Gland, Inflammation, | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Autolysis | 4 | Hyperkeratosis | | Hyperplasia, Basal Cell | | Inflammation, Acute | | Inflammation, Chronic Active | | Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 | Inflammation, Chronic | 1 | Epithelium, Pigmentation | 1 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + M + + +| Hyperplasia | 1 1 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + + + + M + + + + + M M + + + M M + M M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 | Inflammation, Chronic Active | 1 | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 2 | _____________________________________________________________________________________________________________________| Page 88 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 4| 7| 4| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 4| 4| 7| DAY ON TEST | 5| 3| 5| 3| 3| 7| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5| 5| 3| | 5| 1| 5| 1| 1| 8| 8| 1| 4| 1| 0| 0| 1| 0| 1| 4| 0| 0| 0| 7| 7| 2| 7| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Inflammation, Chronic | 1 1 | Inflammation, Chronic Active | 1 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + +| Cyst, Multiple | 3 2 3 3 | Inflammation, Chronic | 1 | Inflammation, Chronic Active | 2 1 1 1 1 | Duct, Dilatation | 2 2 2 2 2 2 3| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 | Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 | Sternal, Myelofibrosis | 1 | __________________________________________________________________________| Lymph Node | + + + + + + + M + + + + + + + + + + + + M + + + +| Mediastinal, Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + M + + + +| Angiectasis | 1 2 1 | Infiltration Cellular, Histiocyte | 1 1 | Pigmentation | 1 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Autolysis | 4 | Depletion Lymphoid | 3 | Hematopoietic Cell Proliferation | 3 | __________________________________________________________________________| Thymus | M + + + + I + + + M + + + + M + M + + M I + + + +| Necrosis | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 | Epidermis, Inflammation, Acute | 2 | Subcutaneous Tissue, Inflammation, | | Chronic Active | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 89 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 4| 7| 4| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 4| 4| 7| DAY ON TEST | 5| 3| 5| 3| 3| 7| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5| 5| 3| | 5| 1| 5| 1| 1| 8| 8| 1| 4| 1| 0| 0| 1| 0| 1| 4| 0| 0| 0| 7| 7| 2| 7| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Infarct | | Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | | Metaplasia, Osseous | 1 | Alveolar Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | + + + + +| __________________________________________________________________________| Harderian Gland | + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 3 | Cyst | | Glomerulosclerosis | 2 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Renal Tubule, Mineralization | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | 4 | Calculus Gross Observation | X X X | Calculus Micro Observation Only | X | Inflammation, Chronic | | _____________________________________________________________________________________________________________________| Page 90 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| | 0| 1| 2| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 2| 5| 2| 2| 2| 5| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + M + + + + + + + + + + + + + + + + + M + +| Autolysis | | Inflammation, Chronic | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Epithelium, Hyperplasia | | Epithelium, Pigmentation | 1 2 1 | Submucosa, Epithelium, Proliferation | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Epithelium, Pigmentation | 1 1 1 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia, Lymphoid | 4 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia, Lymphoid | 3 | Epithelium, Pigmentation | 2 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Hyperplasia, Lymphoid | | Inflammation, Chronic Active | 2 | Epithelium, Pigmentation | 1 2 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Basophilic Focus | | Clear Cell Focus | 2 1 | Eosinophilic Focus | 2 1 1 | Fatty Change | 3 2 1 1 1 1 1 1 1 3 2 2 3 2 1 3 | Mixed Cell Focus | 2 1 1 | Necrosis | 1 1 | __________________________________________________________________________| Mesentery | + + + + | Fibrosis | 1 1 2 2 | Hemorrhage | 2 | Inflammation, Chronic | | Inflammation, Chronic Active | 2 1 | Necrosis, Coagulative | | Necrosis | 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 91 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| | 0| 1| 2| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 2| 5| 2| 2| 2| 5| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Cytoplasmic Alteration | 1 | Inflammation, Chronic | | Duct, Concretion | | Duct, Dilatation | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Submandibular Gland, Inflammation, | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 | Autolysis | | Hyperkeratosis | 1 | Hyperplasia, Basal Cell | | Inflammation, Acute | | Inflammation, Chronic Active | 1 | Epithelium, Hyperplasia | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Inflammation, Chronic | | Epithelium, Pigmentation | 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M M + M M + M M + + I + + I + + + + M + M M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 2 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Inflammation, Chronic Active | | Follicular Cell, Hyperplasia | 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | | _____________________________________________________________________________________________________________________| Page 92 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| | 0| 1| 2| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 2| 5| 2| 2| 2| 5| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Inflammation, Chronic | 1 1 | Inflammation, Chronic Active | 2| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + +| Cyst, Multiple | 3 | Inflammation, Chronic | | Inflammation, Chronic Active | 1 2 1 2 1 1 1| Duct, Dilatation | 2 2 2 2 2 2 2 2 2 1 2| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | Epithelium, Hyperplasia | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Sternal, Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + + M + + + + + + + + + + + + + + + + + + + +| Mediastinal, Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Infiltration Cellular, Histiocyte | 1 1 | Pigmentation | 1 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Autolysis | | Depletion Lymphoid | | Hematopoietic Cell Proliferation | 2 | __________________________________________________________________________| Thymus | + I + M M + + + + + + M M + + + + + + + + + + + M| Necrosis | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Epidermis, Inflammation, Acute | | Subcutaneous Tissue, Inflammation, | | Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 93 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| | 0| 1| 2| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 2| 5| 2| 2| 2| 5| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Infarct | 2 | Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | | Metaplasia, Osseous | | Alveolar Epithelium, Hyperplasia | 1 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Cyst | | Glomerulosclerosis | | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Renal Tubule, Mineralization | 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Autolysis | | Calculus Gross Observation | | Calculus Micro Observation Only | X X | Inflammation, Chronic | | _____________________________________________________________________________________________________________________| Page 94 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 6| 4| 7| 7| 7| 4| 7| 4| 7| | | DAY ON TEST | 3| 2| 5| 3| 3| 3| 5| 3| 5| 3| | | | 2| 7| 7| 2| 2| 2| 7| 2| 7| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A | 50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 55 | Autolysis | 4 | 2 4.0| Inflammation, Chronic | 1 | 1 1.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | Autolysis | | 1 4.0| Epithelium, Hyperplasia | | 1 3.0| Epithelium, Pigmentation | 1 | 8 1.1| Submucosa, Epithelium, Proliferation | | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | Autolysis | | 1 4.0| Epithelium, Pigmentation | 1 | 5 1.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | Autolysis | | 1 4.0| __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | Autolysis | | 1 4.0| Hyperplasia, Lymphoid | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 60 | Autolysis | | 1 4.0| Hyperplasia, Lymphoid | | 1 3.0| Epithelium, Pigmentation | 1 1 | 7 1.3| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | Autolysis | | 1 4.0| Hyperplasia, Lymphoid | | 1 2.0| Inflammation, Chronic Active | | 1 2.0| Epithelium, Pigmentation | 1 1 | 5 1.4| __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Autolysis | 2 | 2 3.0| Basophilic Focus | 1 | 1 1.0| Clear Cell Focus | | 2 1.5| Eosinophilic Focus | 1 1 | 7 1.3| Fatty Change | 1 3 4 2 3 2 1 | 34 2.0| Mixed Cell Focus | | 6 1.3| Necrosis | | 2 1.0| __________________________________________________________________________|____________| Mesentery | | 8 | Fibrosis | | 8 1.6| Hemorrhage | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 95 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 6| 4| 7| 7| 7| 4| 7| 4| 7| | | DAY ON TEST | 3| 2| 5| 3| 3| 3| 5| 3| 5| 3| | | | 2| 7| 7| 2| 2| 2| 7| 2| 7| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A | 50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Inflammation, Chronic | | 1 1.0| Inflammation, Chronic Active | | 4 1.5| Necrosis, Coagulative | | 1 3.0| Necrosis | | 3 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 59 | Cytoplasmic Alteration | 1 2 | 3 1.3| Inflammation, Chronic | 1 1 | 2 1.0| Duct, Concretion | 2 | 1 2.0| Duct, Dilatation | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | Submandibular Gland, Inflammation, | | | Chronic | 1 1 1 1 1 | 42 1.0| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Acanthosis | 2 | 2 1.5| Autolysis | | 1 4.0| Hyperkeratosis | 1 | 2 1.0| Hyperplasia, Basal Cell | 1 | 1 1.0| Inflammation, Acute | 1 | 1 1.0| Inflammation, Chronic Active | 1 | 2 1.0| Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Autolysis | | 1 4.0| Inflammation, Chronic | | 1 1.0| Epithelium, Pigmentation | 1 | 6 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 59 | Hyperplasia | | 5 1.4| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + + + | 40 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 60 | Pars Distalis, Cyst | | 2 1.5| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 96 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 6| 4| 7| 7| 7| 4| 7| 4| 7| | | DAY ON TEST | 3| 2| 5| 3| 3| 3| 5| 3| 5| 3| | | | 2| 7| 7| 2| 2| 2| 7| 2| 7| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A | 50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Autolysis | | 1 4.0| Inflammation, Chronic Active | | 1 1.0| Follicular Cell, Hyperplasia | | 3 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | Granuloma Sperm | | 1 2.0| Inflammation, Chronic | 1 1 | 6 1.0| Inflammation, Chronic Active | | 2 1.5| __________________________________________________________________________|____________| Preputial Gland | + + + + + + | 31 | Cyst, Multiple | 2 3 | 7 2.7| Inflammation, Chronic | 1 | 2 1.0| Inflammation, Chronic Active | 1 1 2 | 15 1.3| Duct, Dilatation | 2 | 19 2.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 60 | Inflammation, Chronic | 1 | 4 1.0| Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + | 49 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Autolysis | | 1 4.0| Sternal, Myelofibrosis | | 1 1.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 57 | Mediastinal, Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + I + | 56 | Angiectasis | | 4 1.3| Infiltration Cellular, Histiocyte | 1 1 | 6 1.0| Pigmentation | 1 | 5 1.0| __________________________________________________________________________|____________| Spleen | + + + + + + + M + + | 59 | Angiectasis | | 1 1.0| Autolysis | | 1 4.0| Depletion Lymphoid | | 1 3.0| Hematopoietic Cell Proliferation | 3 | 3 2.7| __________________________________________________________________________|____________| Thymus | + M + + + + + + + + | 46 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 97 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 6| 4| 7| 7| 7| 4| 7| 4| 7| | | DAY ON TEST | 3| 2| 5| 3| 3| 3| 5| 3| 5| 3| | | | 2| 7| 7| 2| 2| 2| 7| 2| 7| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A | 50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Necrosis | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Autolysis | | 1 4.0| Epidermis, Inflammation, Acute | | 1 2.0| Subcutaneous Tissue, Inflammation, | | | Chronic Active | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Infarct | | 1 2.0| Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 | 55 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Infiltration Cellular, Histiocyte | 2 | 1 2.0| Metaplasia, Osseous | | 1 1.0| Alveolar Epithelium, Hyperplasia | | 3 1.3| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | Inflammation, Acute | 1 1 | 4 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | Autolysis | | 1 4.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Eye | | 6 | __________________________________________________________________________|____________| Harderian Gland | | 6 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Autolysis | | 1 3.0| Cyst | 1 | 1 1.0| Glomerulosclerosis | | 1 2.0| Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 | 45 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 98 NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97 Route: DOSED FEED Time: 07:39:50 __________________________________________________________________________________________________________________________________ | 7| 6| 4| 7| 7| 7| 4| 7| 4| 7| | | DAY ON TEST | 3| 2| 5| 3| 3| 3| 5| 3| 5| 3| | | | 2| 7| 7| 2| 2| 2| 7| 2| 7| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A | 50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Renal Tubule, Mineralization | | 3 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | Autolysis | | 1 4.0| Calculus Gross Observation | | 3 | Calculus Micro Observation Only | | 3 | Inflammation, Chronic | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 99 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------