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TDMS Study 05084-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         TURMERIC OLEORESIN


NTP Experiment-Test: 05084-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: DOSED FEED                                                                                                 Time: 21:38:55




       Facility:  TSI Mason Research

       Chemical CAS #:  458-37-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05084-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10            9                                     
  Early Deaths                                                                                                                      
    Dead                                               3            1            3            2                                     
    Moribund                                          14           22           19           15                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           26           28           34                                     
    Dead                                               1            1                                                               
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (60)         (60)         (60)         (60)                                   
   Intestine Large, Colon                             (60)         (60)         (60)         (59)                                   
   Intestine Small, Duodenum                          (60)         (60)         (60)         (60)                                   
   Intestine Small, Ileum                             (60)         (60)         (59)         (60)                                   
   Intestine Small, Jejunum                           (60)         (59)         (60)         (60)                                   
   Liver                                              (60)         (52)         (54)         (60)                                   
      Hepatocellular Adenoma                           1 (2%)                                                                       
   Mesentery                                          (5)          (4)          (4)          (2)                                    
      Leiomyoma                                                                  1 (25%)                                            
      Sarcoma                                                       1 (25%)                                                         
   Pancreas                                           (60)         (50)         (50)         (59)                                   
   Pharynx                                            (1)                                    (1)                                    
      Palate, Squamous Cell Carcinoma                  1 (100%)                               1 (100%)                              
   Salivary Glands                                    (60)         (50)         (50)         (60)                                   
      Parotid Gland, Schwannoma Malignant                           1 (2%)                                                          
      Submandibular Gland, Schwannoma Malignant                     1 (2%)                                                          
   Stomach, Forestomach                               (60)         (60)         (59)         (60)                                   
      Squamous Cell Papilloma                          1 (2%)       1 (2%)       1 (2%)                                             
   Stomach, Glandular                                 (60)         (60)         (59)         (60)                                   
   Tongue                                                          (1)                       (1)                                    
      Squamous Cell Papilloma                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (50)         (50)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05084-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (50)         (51)         (59)                                   
      Adenoma                                                                    3 (6%)       1 (2%)                                
   Adrenal Gland, Medulla                             (60)         (49)         (50)         (59)                                   
      Pheochromocytoma Benign                          3 (5%)                    2 (4%)       2 (3%)                                
   Islets, Pancreatic                                 (59)         (50)         (50)         (59)                                   
      Adenoma                                          2 (3%)                                 1 (2%)                                
      Carcinoma                                        1 (2%)                                 1 (2%)                                
   Parathyroid Gland                                  (55)         (47)         (49)         (55)                                   
   Pituitary Gland                                    (60)         (49)         (52)         (60)                                   
      Pars Distalis, Adenoma                          25 (42%)     25 (51%)     24 (46%)     24 (40%)                               
      Pars Distalis, Adenoma, Multiple                 3 (5%)       2 (4%)       1 (2%)       1 (2%)                                
      Pars Distalis, Carcinoma                         2 (3%)                    1 (2%)                                             
   Thyroid Gland                                      (60)         (51)         (52)         (60)                                   
      C-Cell, Adenoma                                  6 (10%)      2 (4%)       3 (6%)       3 (5%)                                
      C-Cell, Carcinoma                                2 (3%)                    1 (2%)                                             
      Follicular Cell, Adenocarcinoma                               1 (2%)                                                          
      Follicular Cell, Adenoma                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                       (1)          (2)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (60)         (51)         (49)         (58)                                   
      Adenocarcinoma                                   1 (2%)       4 (8%)                                                          
      Adenoma                                          7 (12%)     13 (25%)     15 (31%)     17 (29%)                               
      Adenoma, Multiple                                                          1 (2%)                                             
   Ovary                                              (60)         (51)         (51)         (60)                                   
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
      Granulosa Cell Tumor Benign                      2 (3%)                                                                       
   Uterus                                             (60)         (50)         (50)         (60)                                   
      Leiomyosarcoma                                   1 (2%)                                                                       
      Polyp Stromal                                   10 (17%)     10 (20%)     11 (22%)      9 (15%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)                                                                           
   Bone Marrow                                        (60)         (60)         (52)         (60)                                   
   Lymph Node                                         (60)         (60)         (56)         (60)                                   
   Lymph Node, Mandibular                             (4)          (9)          (6)          (7)                                    
   Lymph Node, Mesenteric                             (60)         (60)         (56)         (60)                                   
   Spleen                                             (60)         (50)         (51)         (60)                                   
                                                             Page   3                                                               
NTP Experiment-Test: 05084-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (51)         (48)         (45)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (49)         (49)         (59)                                   
      Adenocarcinoma                                   2 (3%)       1 (2%)       2 (4%)                                             
      Adenoma                                          1 (2%)                                                                       
      Fibroadenoma                                     7 (12%)     18 (37%)     17 (35%)     14 (24%)                               
      Fibroadenoma, Multiple                           6 (10%)      4 (8%)       2 (4%)       2 (3%)                                
   Skin                                               (58)         (50)         (51)         (59)                                   
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant                     2 (4%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (50)         (60)                                   
      Astrocytoma Malignant                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (52)         (52)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)                    2 (4%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
      Sarcoma, Metastatic, Mesentery                                1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Uncertain Primary Site                                                 1 (2%)                                             
   Nose                                               (59)         (56)         (52)         (60)                                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (9)          (10)         (7)          (13)                                   
   Zymbal's Gland                                     (2)                       (1)                                                 
      Adenocarcinoma                                   1 (50%)                                                                      
      Carcinoma                                        1 (50%)                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 05084-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (51)         (49)         (60)                                   
   Urinary Bladder                                    (60)         (48)         (49)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Mononuclear                            15 (25%)     19 (32%)     18 (30%)     21 (35%)                               
      Lymphoma Malignant Mixed                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05084-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            53          50          49          49                                       
     Total Primary Neoplasms                          105         106         110         100                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          47          44          44                                       
     Total Benign Neoplasms                            76          75          84          76                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          25          24          24                                       
     Total Malignant Neoplasms                         29          31          26          24                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           1                                                   
     Total Metastatic Neoplasm                          1           1           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05084-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10            9                                     
  Early Deaths                                                                                                                      
    Moribund                                          26           29           32           28                                     
    Dead                                               6            4            3            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                18           17           15           17                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (59)         (49)         (49)         (58)                                   
   Intestine Large, Cecum                             (60)         (59)         (60)         (60)                                   
   Intestine Large, Colon                             (59)         (60)         (59)         (58)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
   Intestine Small, Duodenum                          (60)         (60)         (59)         (60)                                   
   Intestine Small, Ileum                             (59)         (60)         (59)         (60)                                   
   Intestine Small, Jejunum                           (60)         (60)         (59)         (58)                                   
      Sarcoma                                                                    1 (2%)                                             
   Liver                                              (60)         (57)         (56)         (60)                                   
      Hepatocellular Carcinoma                         1 (2%)                    1 (2%)       1 (2%)                                
      Hepatocellular Adenoma                                        1 (2%)       3 (5%)       2 (3%)                                
      Hepatocellular Adenoma, Multiple                                           1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Mesentery                                          (9)          (3)          (8)          (7)                                    
      Liposarcoma                                                                1 (13%)                                            
   Pancreas                                           (58)         (50)         (50)         (59)                                   
      Mixed Tumor Benign                                            1 (2%)                                                          
   Salivary Glands                                    (59)         (49)         (50)         (59)                                   
   Stomach, Forestomach                               (59)         (60)         (53)         (60)                                   
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (58)                                   
   Tongue                                                          (1)          (1)          (3)                                    
      Squamous Cell Papilloma                                                                 1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (50)         (50)         (60)                                   
      Schwannoma Benign                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05084-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (50)         (50)         (60)                                   
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Adrenal Gland, Medulla                             (57)         (50)         (51)         (59)                                   
      Pheochromocytoma Malignant                                    1 (2%)       2 (4%)       1 (2%)                                
      Pheochromocytoma Benign                          9 (16%)     15 (30%)     13 (25%)      6 (10%)                               
      Pheochromocytoma Benign, Multiple                5 (9%)       5 (10%)      5 (10%)      3 (5%)                                
   Islets, Pancreatic                                 (57)         (50)         (48)         (58)                                   
      Adenoma                                          2 (4%)       1 (2%)       1 (2%)       3 (5%)                                
      Carcinoma                                                                  1 (2%)                                             
   Parathyroid Gland                                  (56)         (47)         (49)         (55)                                   
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (60)         (51)         (50)         (58)                                   
      Pars Distalis, Adenoma                          25 (42%)     16 (31%)     15 (30%)     12 (21%)                               
      Pars Distalis, Adenoma, Multiple                 1 (2%)       2 (4%)       2 (4%)       2 (3%)                                
      Pars Intermedia, Adenoma                                                                1 (2%)                                
      Pars Nervosa, Adenoma                            1 (2%)                                                                       
      Pars Nervosa, Craniopharyngioma                               1 (2%)                                                          
   Thyroid Gland                                      (59)         (50)         (51)         (60)                                   
      Carcinoma                                                                  1 (2%)                                             
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      C-Cell, Adenoma                                  4 (7%)       7 (14%)      5 (10%)      6 (10%)                               
      C-Cell, Carcinoma                                2 (3%)                                                                       
      Follicular Cell, Adenocarcinoma                               1 (2%)                                                          
      Follicular Cell, Adenoma                         1 (2%)       2 (4%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (10)         (2)          (2)          (9)                                    
   Epididymis                                         (59)         (50)         (50)         (59)                                   
   Preputial Gland                                    (57)         (51)         (50)         (60)                                   
      Adenocarcinoma                                   2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
      Adenoma                                          2 (4%)       5 (10%)      2 (4%)       3 (5%)                                
      Bilateral, Adenoma                               1 (2%)                                                                       
   Prostate                                           (60)         (50)         (50)         (60)                                   
   Seminal Vesicle                                    (60)         (50)         (51)         (59)                                   
   Testes                                             (60)         (53)         (54)         (60)                                   
      Bilateral, Interstitial Cell, Adenoma           31 (52%)     39 (74%)     34 (63%)     34 (57%)                               
      Interstitial Cell, Adenoma                       9 (15%)      8 (15%)     10 (19%)      9 (15%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05084-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (50)         (49)         (60)                                   
      Sternal, Histiocytic Sarcoma                                               1 (2%)                                             
   Lymph Node                                         (59)         (60)         (60)         (60)                                   
   Lymph Node, Mandibular                             (22)         (15)         (22)         (17)                                   
      Squamous Cell Carcinoma, Metastatic              1 (5%)                                                                       
   Lymph Node, Mesenteric                             (59)         (60)         (60)         (60)                                   
   Spleen                                             (60)         (52)         (50)         (59)                                   
   Thymus                                             (50)         (48)         (45)         (52)                                   
      Thymoma Benign                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (39)         (40)         (50)                                   
      Adenocarcinoma                                                             1 (3%)                                             
      Adenoma, Multiple                                1 (2%)                                                                       
      Fibroadenoma                                                               1 (3%)       1 (2%)                                
   Skin                                               (60)         (51)         (53)         (60)                                   
      Basal Cell Adenoma                                                                      1 (2%)                                
      Fibroma                                                       1 (2%)                                                          
      Fibrosarcoma                                                  1 (2%)                                                          
      Keratoacanthoma                                                            3 (6%)                                             
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          3 (5%)                    2 (4%)       1 (2%)                                
      Squamous Cell Papilloma, Multiple                1 (2%)                                                                       
      Sebaceous Gland, Adenoma                                                   1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     2 (3%)       1 (2%)       1 (2%)       3 (5%)                                
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
      Subcutaneous Tissue, Hemangioma                                                         1 (2%)                                
      Subcutaneous Tissue, Lipoma                                   1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)       1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (1)          (1)                                    
      Rhabdomyosarcoma                                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05084-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (50)         (60)                                   
      Astrocytoma Malignant                                         1 (2%)       1 (2%)                                             
      Glioma Malignant                                              1 (2%)                                                          
      Meninges, Granular Cell Tumor Benign                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (57)         (57)         (60)                                   
      Adenocarcinoma, Metastatic, Thyroid Gland                     1 (2%)                                                          
      Alveolar/Bronchiolar Adenoma                     2 (3%)       2 (4%)       5 (9%)       2 (3%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)                                                          
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (2%)                                                          
   Nose                                               (60)         (50)         (50)         (59)                                   
      Chondroma                                        1 (2%)                                                                       
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Respiratory Epithelium, Adenoma                                            1 (2%)                                             
   Trachea                                            (60)         (50)         (50)         (60)                                   
      Adenocarcinoma, Metastatic, Thyroid Gland                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                       (3)                                    
      Pinna, Schwannoma Malignant                                                             1 (33%)                               
   Eye                                                (15)         (5)          (7)          (9)                                    
      Lids, Fibroma                                                              1 (14%)                                            
   Zymbal's Gland                                                               (1)          (1)                                    
      Adenocarcinoma                                                                          1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (52)         (50)         (60)                                   
      Renal Tubule, Adenoma                                                      1 (2%)                                             
   Urinary Bladder                                    (59)         (50)         (50)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leukemia Mononuclear                            27 (45%)     29 (48%)     35 (58%)     23 (38%)                               
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05084-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Mesothelioma Benign                                           1 (2%)                                                          
      Mesothelioma Malignant                                        2 (3%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                             Page  11                                                               
NTP Experiment-Test: 05084-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            56          55          55          49                                       
     Total Primary Neoplasms                          143         153         160         125                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 54          53          53          48                                       
     Total Benign Neoplasms                           104         113         111          94                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              34          36          40          26                                       
     Total Malignant Neoplasms                         39          40          49          31                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2           1                                                   
     Total Metastatic Neoplasm                          2           3           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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